Comparable bio-evaluation of curcumin and chitosan-encapsulated curcumin nanoparticles against the reprotoxic potential of fenpropathrin pyrethroid in rats: Genomic and morphometric prospectives
This study delves into the intricate exploration of potential toxic effects resulting from subchronic exposure to fenpropathrin (FNP) on the reproductive system of male SD rats. Adding to the novelty, our study undertakes a pioneering comparison of the effects of curcumin (CUR) and curcumin-encapsulated chitosan nanoparticles (CS.CUR.NPs) on these toxic effects. The study involved a cohort of sixty male SD rats (six groups): vehicle control, CUR, Cs.CUR.NPs, FNP, and two combination groups (FNP with CUR or Cs.CUR.NPs). The synthesized Cs.CUR.NPs nanoparticles underwent meticulous characterization using Fourier Infrared spe...
Source: Food and Chemical Toxicology - August 2, 2023 Category: Food Science Authors: Amany Abdel-Rahman Mohamed Amany Behairy Yasmina M Abd El-Hakim Mohamed M M Metwally Tarek Khamis Samah S Abuzahrah Ahmed E Abdelhamid Leena S Alqahtani Walaa M Essawi Badriyah S Alotaibi Manal Alosaimi Rehab Ahmed Ahmed El-Shaer Marwa Mahmoud Awad Eman S Source Type: research
The occurrence and probabilistic risk assessment of 3-MCPDEs and GEs in infant formulas from Chinese market employing Monte Carlo simulation technique
This study is the first report on probabilistic assessment of 3-MCPDEs and GEs in IFs, which also provided references for the formulation of related regulatory limits in China.PMID:37532171 | DOI:10.1016/j.fct.2023.113978 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - August 2, 2023 Category: Food Science Authors: Zhengchao Shen Kexin Tian Muhammad Mujahid Ali Sifan Mei Xin Ma Jiang Liang Feng Pan Jianwen Li Haixia Sui Zhenxia Du Source Type: research
In silico and in vitro safety assessment of a fungal biomass from Rhizomucor pusillus for use as a novel food ingredient
Food Chem Toxicol. 2023 Jul 31:113972. doi: 10.1016/j.fct.2023.113972. Online ahead of print.ABSTRACTTo address the growing world population and reduce the impact of environmental changes on the global food supply, ingredients are being produced using microorganisms to yield sustainable and innovative products. Food ingredients manufactured using modern biotechnology must be produced by non-toxigenic and nonpathogenic production organisms that do not harbor antimicrobial resistance (AMR). Several fungal species represent attractive targets as sources of alternative food products. One such product is a fungal biomass obtain...
Source: Food and Chemical Toxicology - August 2, 2023 Category: Food Science Authors: Kevin Scaife Trung D Vo Yvonne Dommels Elisa Leune Kaj Albermann Lucie Pa řenicová Source Type: research
Environmental endocrine disruptors and pregnane X receptor action: A review
Food Chem Toxicol. 2023 Jul 31;179:113976. doi: 10.1016/j.fct.2023.113976. Online ahead of print.ABSTRACTThe pregnane X receptor (PXR) is a kind of orphan nuclear receptor activated by a series of ligands. Environmental endocrine disruptors (EEDs) are a wide class of molecules present in the environment that are suspected to have adverse effects on the endocrine system by interfering with the synthesis, transport, degradation, or action of endogenous hormones. Since EEDs may modulate human/rodent PXR, this review aims to summarize EEDs as PXR modulators, including agonists and antagonists. The modular structure of PXR is a...
Source: Food and Chemical Toxicology - August 2, 2023 Category: Food Science Authors: Yuan Liang Yiyao Gong Qiuyan Jiang Yifan Yu Jie Zhang Source Type: research
Comparable bio-evaluation of curcumin and chitosan-encapsulated curcumin nanoparticles against the reprotoxic potential of fenpropathrin pyrethroid in rats: Genomic and morphometric prospectives
This study delves into the intricate exploration of potential toxic effects resulting from subchronic exposure to fenpropathrin (FNP) on the reproductive system of male SD rats. Adding to the novelty, our study undertakes a pioneering comparison of the effects of curcumin (CUR) and curcumin-encapsulated chitosan nanoparticles (CS.CUR.NPs) on these toxic effects. The study involved a cohort of sixty male SD rats (six groups): vehicle control, CUR, Cs.CUR.NPs, FNP, and two combination groups (FNP with CUR or Cs.CUR.NPs). The synthesized Cs.CUR.NPs nanoparticles underwent meticulous characterization using Fourier Infrared spe...
Source: Food and Chemical Toxicology - August 2, 2023 Category: Food Science Authors: Amany Abdel-Rahman Mohamed Amany Behairy Yasmina M Abd El-Hakim Mohamed M M Metwally Tarek Khamis Samah S Abuzahrah Ahmed E Abdelhamid Leena S Alqahtani Walaa M Essawi Badriyah S Alotaibi Manal Alosaimi Rehab Ahmed Ahmed El-Shaer Marwa Mahmoud Awad Eman S Source Type: research
The occurrence and probabilistic risk assessment of 3-MCPDEs and GEs in infant formulas from Chinese market employing Monte Carlo simulation technique
This study is the first report on probabilistic assessment of 3-MCPDEs and GEs in IFs, which also provided references for the formulation of related regulatory limits in China.PMID:37532171 | DOI:10.1016/j.fct.2023.113978 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - August 2, 2023 Category: Food Science Authors: Zhengchao Shen Kexin Tian Muhammad Mujahid Ali Sifan Mei Xin Ma Jiang Liang Feng Pan Jianwen Li Haixia Sui Zhenxia Du Source Type: research
In silico and in vitro safety assessment of a fungal biomass from Rhizomucor pusillus for use as a novel food ingredient
Food Chem Toxicol. 2023 Jul 31:113972. doi: 10.1016/j.fct.2023.113972. Online ahead of print.ABSTRACTTo address the growing world population and reduce the impact of environmental changes on the global food supply, ingredients are being produced using microorganisms to yield sustainable and innovative products. Food ingredients manufactured using modern biotechnology must be produced by non-toxigenic and nonpathogenic production organisms that do not harbor antimicrobial resistance (AMR). Several fungal species represent attractive targets as sources of alternative food products. One such product is a fungal biomass obtain...
Source: Food and Chemical Toxicology - August 2, 2023 Category: Food Science Authors: Kevin Scaife Trung D Vo Yvonne Dommels Elisa Leune Kaj Albermann Lucie Pa řenicová Source Type: research
Environmental endocrine disruptors and pregnane X receptor action: A review
Food Chem Toxicol. 2023 Jul 31;179:113976. doi: 10.1016/j.fct.2023.113976. Online ahead of print.ABSTRACTThe pregnane X receptor (PXR) is a kind of orphan nuclear receptor activated by a series of ligands. Environmental endocrine disruptors (EEDs) are a wide class of molecules present in the environment that are suspected to have adverse effects on the endocrine system by interfering with the synthesis, transport, degradation, or action of endogenous hormones. Since EEDs may modulate human/rodent PXR, this review aims to summarize EEDs as PXR modulators, including agonists and antagonists. The modular structure of PXR is a...
Source: Food and Chemical Toxicology - August 2, 2023 Category: Food Science Authors: Yuan Liang Yiyao Gong Qiuyan Jiang Yifan Yu Jie Zhang Source Type: research
Deoxynivalenol upregulates hypoxia-inducible factor-1 α to promote an "immune evasion" process by activating STAT3 signaling
This study offers further clues for accurate prevention and treatment of immune diseases caused by mycotoxins.PMID:37517547 | DOI:10.1016/j.fct.2023.113975 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - July 30, 2023 Category: Food Science Authors: Luying Zhang Xu Wang Eugenie Nepovimova Qinghua Wu Wenda Wu Kamil Kuca Source Type: research
Novel landmarks on the journey from natural products to pharmaceutical formulations: Phytochemical, biological, toxicological and computational activities of Satureja hortensis L
This study examined the ethanolic extract of the Satureja hortensis L. plant's aerial parts to describe its phytochemical makeup, biological functions, toxicity tests, and in-silico molecular docking tests. The GC-MS analysis was used to evaluate the phytochemical composition of the tested extract, and the ABTS and hydrogen peroxide antioxidant assays were used to measure antioxidant activity. Aspergillus fumigatus, Candida albicans, Staphylococcus aureus, Bacillus subtilis, Escherichia coli, and Proteus vulgaris were tested for antimicrobial potential. On cell lines such as HepG-2, MCF-7, A-549, and Panc-1, the in-vitro t...
Source: Food and Chemical Toxicology - July 30, 2023 Category: Food Science Authors: Bader Huwaimel Amr S Abouzied Sirajudheen Anwar Mahmoud M Elaasser Suliman A Almahmoud Bahaa Alshammari Dareen Alrdaian Reem Q Alshammari Source Type: research
Deoxynivalenol upregulates hypoxia-inducible factor-1 α to promote an "immune evasion" process by activating STAT3 signaling
This study offers further clues for accurate prevention and treatment of immune diseases caused by mycotoxins.PMID:37517547 | DOI:10.1016/j.fct.2023.113975 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - July 30, 2023 Category: Food Science Authors: Luying Zhang Xu Wang Eugenie Nepovimova Qinghua Wu Wenda Wu Kamil Kuca Source Type: research
Novel landmarks on the journey from natural products to pharmaceutical formulations: Phytochemical, biological, toxicological and computational activities of Satureja hortensis L
This study examined the ethanolic extract of the Satureja hortensis L. plant's aerial parts to describe its phytochemical makeup, biological functions, toxicity tests, and in-silico molecular docking tests. The GC-MS analysis was used to evaluate the phytochemical composition of the tested extract, and the ABTS and hydrogen peroxide antioxidant assays were used to measure antioxidant activity. Aspergillus fumigatus, Candida albicans, Staphylococcus aureus, Bacillus subtilis, Escherichia coli, and Proteus vulgaris were tested for antimicrobial potential. On cell lines such as HepG-2, MCF-7, A-549, and Panc-1, the in-vitro t...
Source: Food and Chemical Toxicology - July 30, 2023 Category: Food Science Authors: Bader Huwaimel Amr S Abouzied Sirajudheen Anwar Mahmoud M Elaasser Suliman A Almahmoud Bahaa Alshammari Dareen Alrdaian Reem Q Alshammari Source Type: research
Deoxynivalenol upregulates hypoxia-inducible factor-1 α to promote an "immune evasion" process by activating STAT3 signaling
This study offers further clues for accurate prevention and treatment of immune diseases caused by mycotoxins.PMID:37517547 | DOI:10.1016/j.fct.2023.113975 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - July 30, 2023 Category: Food Science Authors: Luying Zhang Xu Wang Eugenie Nepovimova Qinghua Wu Wenda Wu Kamil Kuca Source Type: research
Novel landmarks on the journey from natural products to pharmaceutical formulations: Phytochemical, biological, toxicological and computational activities of Satureja hortensis L
This study examined the ethanolic extract of the Satureja hortensis L. plant's aerial parts to describe its phytochemical makeup, biological functions, toxicity tests, and in-silico molecular docking tests. The GC-MS analysis was used to evaluate the phytochemical composition of the tested extract, and the ABTS and hydrogen peroxide antioxidant assays were used to measure antioxidant activity. Aspergillus fumigatus, Candida albicans, Staphylococcus aureus, Bacillus subtilis, Escherichia coli, and Proteus vulgaris were tested for antimicrobial potential. On cell lines such as HepG-2, MCF-7, A-549, and Panc-1, the in-vitro t...
Source: Food and Chemical Toxicology - July 30, 2023 Category: Food Science Authors: Bader Huwaimel Amr S Abouzied Sirajudheen Anwar Mahmoud M Elaasser Suliman A Almahmoud Bahaa Alshammari Dareen Alrdaian Reem Q Alshammari Source Type: research
The food additive titanium dioxide hinders intestinal production of TGF- β and IL-10 in mice, and long-term exposure in adults or from perinatal life blocks oral tolerance to ovalbumin
Food Chem Toxicol. 2023 Jul 27:113974. doi: 10.1016/j.fct.2023.113974. Online ahead of print.ABSTRACTFood hypersensitivities are increasing in industrialized countries, and foodborne nanoparticles (NPs) are suspected as co-factors in their aetiology. Food-grade titanium dioxide (fg-TiO2), a food colouring agent, is composed of NPs with immunomodulatory properties. We investigated whether fg-TiO2 may compromise the establishment of oral tolerance (OT) to food proteins using a model of OT induction to ovalbumin (OVA) in mice, and whether a perinatal exposure could trigger this effect. In pregnant mice fed a TiO2-enriched die...
Source: Food and Chemical Toxicology - July 29, 2023 Category: Food Science Authors: Bruno Lamas Laurence Chevalier Eric Gaultier Christel Cartier Laurent Weingarten Xavier Blanc Paola Fisicaro Caroline Oster Johanna Noireaux Lauris Evariste Natalia Martins Breyner Eric Houdeau Source Type: research
