Acute and chronic cannabidiol treatment: In vitro toxicological aspects on human oral cells
Food Chem Toxicol. 2024 Feb 9;185:114513. doi: 10.1016/j.fct.2024.114513. Online ahead of print.ABSTRACTCannabidiol is gaining increasing interest for its potential anti-inflammatory, immunomodulatory, and antineoplastic effects. The purpose of this study is to investigate the biological effects of acute and chronic CBD administration on gingival fibroblasts and oral keratinocytes. Viability, morphology, migration, apoptosis and cell cycle, and expression of related genes (p53, BCL2, p21, and BAX) and of endocannabinoid system receptors (CB1, CB2 and GPR55) with real-time PCR and DNA damage with phospho-γ-H2AX immunofluor...
Source: Food and Chemical Toxicology - February 11, 2024 Category: Food Science Authors: Stefano Pagano Chiara Valenti Paolo Negri Monia Billi Alessandro Di Michele Stefano Bruscoli Marta Febo Maddalena Coniglio Lorella Marinucci Source Type: research
Application of duplex sequencing to evaluate mutagenicity of aristolochic acid and methapyrilene in Fisher 344 rats
In this study, we evaluated the mutagenicity of aristolochic acid, a known genotoxic carcinogen, and methapyrilene, a known nongenotoxic carcinogen using DS. Four male Fisher 344 rats were treated with aristolochic acid, methapyrilene, or the vehicle control for 6 weeks, liver tissues were collected one day after the treatment, and the DNA was isolated for analysis. The mutation frequency for the aristolochic acid-treated group was significantly increased over the vehicle control (44-fold), whereas no significant difference in the mutation frequency was observed between the methapyrilene-treated and the control groups. The...
Source: Food and Chemical Toxicology - February 11, 2024 Category: Food Science Authors: Seaab Sahib Jian Yan Tao Chen Source Type: research
Update to RIFM fragrance ingredient safety assessment, butyl benzoate, CAS Registry Number 136-60-7
Food Chem Toxicol. 2024 Feb 8:114500. doi: 10.1016/j.fct.2024.114500. Online ahead of print.NO ABSTRACTPMID:38341170 | DOI:10.1016/j.fct.2024.114500 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - February 10, 2024 Category: Food Science Authors: A M Api A Bartlett D Belsito D Botelho M Bruze A Bryant-Freidrich G A Burton M A Cancellieri H Chon M L Dagli W Dekant C Deodhar K Farrell A D Fryer L Jones K Joshi A Lapczynski M Lavelle I Lee H Moustakas J Muldoon T M Penning G Ritacco N Sadekar I Schem Source Type: research
Risk characterization of N-nitrosodimethylamine in pharmaceuticals
Food Chem Toxicol. 2024 Feb 8:114498. doi: 10.1016/j.fct.2024.114498. Online ahead of print.ABSTRACTSince 2018, N-nitrosodimethylamine (NDMA) has been a reported contaminant in numerous pharmaceutical products. To guide the pharmaceutical industry, FDA identified an acceptable intake (AI) of 96 ng/day NDMA. The FDA approach assumed a linear extrapolation from the Carcinogenic Potency Database (CPDB) harmonic-mean TD50 identified in chronic studies in rats. Although NDMA has been thought to act as a mutagenic carcinogen in experimental animals, it has not been classified as a known human carcinogen by any regulatory agency....
Source: Food and Chemical Toxicology - February 10, 2024 Category: Food Science Authors: D J Paustenbach S E Brown J J Heywood M T Donnell D L Eaton Source Type: research
RIFM fragrance ingredient safety assessment, p-isopropyl phenylacetaldehyde, CAS Registry Number 4395-92-0
Food Chem Toxicol. 2024 Feb 8;183 Suppl 1:114497. doi: 10.1016/j.fct.2024.114497. Online ahead of print.NO ABSTRACTPMID:38336015 | DOI:10.1016/j.fct.2024.114497 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - February 9, 2024 Category: Food Science Authors: A M Api A Bartlett D Belsito D Botelho M Bruze A Bryant-Freidrich G A Burton M A Cancellieri H Chon M L Dagli W Dekant C Deodhar K Farrell A D Fryer L Jones K Joshi A Lapczynski M Lavelle I Lee H Moustakas J Muldoon T M Penning G Ritacco N Sadekar I Schem Source Type: research
Sub-chronic oral toxicity of a water-soluble extract of Centella asiatica (Centell-S) in Wistar rats
CONCLUSIONS: Under the specific conditions of the OECD GLP 408, Repeated Dose 90-day Oral Toxicity Study in Rodents, the no observed adverse effect level (NOAEL) of Centell-S was 800 mg/kg/day. These findings are promising for the continued development of Centell-S as a phytopharmaceutical for clinical applications.PMID:38336016 | DOI:10.1016/j.fct.2024.114509 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - February 9, 2024 Category: Food Science Authors: Thammaporn Junsai Supawit Tangpanithandee Passaraporn Srimangkornkaew Kran Suknuntha Pornpun Vivithanaporn Phisit Khemawoot Source Type: research
Manganese induces neuronal apoptosis by activating mTOR signaling pathway in vitro and in vivo
Food Chem Toxicol. 2024 Feb 7;185:114508. doi: 10.1016/j.fct.2024.114508. Online ahead of print.ABSTRACTManganese (Mn) is a well-known environmental pollutant and occupational toxicant that causes neurotoxicity, which present as neurodegenerative-like symptoms. However, the mechanism of Mn-induced neuronal injury remains unclear. In this research, we explored the mechanism of Mn-induced neurotoxicity, focusing on the mTOR signaling pathway. A plasmid expressing a short hairpin RNA (shRNA) targeting mTOR (shRNA-mTOR) was transfected into N27 cells in vitro, and rapamycin was used as an mTOR inhibitor in vivo to block the mT...
Source: Food and Chemical Toxicology - February 9, 2024 Category: Food Science Authors: Yuyan Cen Jianmin Yang Liyu Su Feng Wang Deyu Zhu Lan Zhao Yan Li Source Type: research
Tris(1,3-dichloro-2-propyl) phosphate induces endoplasmic reticulum stress and mitochondrial-dependent apoptosis in mouse spermatocyte GC-2 cells
In this study, mouse spermatocyte GC-2spd (GC-2) cells were selected as an in vitro model, and the impact of mitochondrial structure and function, endoplasmic reticulum (ER) stress, cell apoptosis and the related molecular mechanisms were investigated. Our study indicated that cell viability was decreased significantly in a dose-dependent manner after TDCIPP treatment with the half lethal concentration (LC50) at 82.8 μM, 50.0 μM and 39.6 μM for 24 h, 48 h and 72 h, respectively. An apoptosis was observed by Annexin V-FITC/PI stain. In addition, fragmentation of mitochondrial structure, an increase of mitochondrial membr...
Source: Food and Chemical Toxicology - February 8, 2024 Category: Food Science Authors: Yixing Feng Zisong Wang Hejun Duan Bing Shao Source Type: research
Comparative systematic review on the safety of e-cigarettes and conventional cigarettes
CONCLUSION: However, concerns persist regarding respiratory irritation and potential health risks, especially among youth, emphasizing the need for comprehensive, long-term research and protective legislation.PMID:38331086 | DOI:10.1016/j.fct.2024.114507 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - February 8, 2024 Category: Food Science Authors: Josef Yayan Karl-Josef Franke Christian Biancosino Kurt Rasche Source Type: research
Considerations for deriving a safe intake of propylene glycol
Food Chem Toxicol. 2024 Feb 5:114460. doi: 10.1016/j.fct.2024.114460. Online ahead of print.ABSTRACTThe use of propylene glycol (PG) in food and other applications is widespread, and some estimates of dietary exposure to PG approach or exceed the Acceptable Daily Intake (ADI) of 25 mg/kg bw-day. The current ADI for PG applies a cumulative uncertainty factor of 100, which includes factors of 10 for both interspecies and intraspecies differences. Available toxicology studies and human data, however, indicate a plausible mode of action (MoA) that would support a chemical-specific adjustment factor (CSAF) of 1 for interspecies...
Source: Food and Chemical Toxicology - February 7, 2024 Category: Food Science Authors: Ari S Lewis Steven R Boomhower Charlotte M Marsh Maia M Jack Source Type: research
Propyl gallate exposure affects the mouse 2-cell stage embryonic development through inducing oxidative stress and autophagy
In this study, we explored the toxic effects and potential mechanisms of PG on mouse 2-cell stage embryonic development. The results showed that exposure of PG can decrease the development of 2-cell stage embryos and repress the development of 4-cell stage embryos. Further study found that PG could induce intracellular oxidative stress and the accumulation of DNA damage in 2-cell stage embryos. Moreover, exposure of PG impaired the function of mitochondria and lysosomes in 2-cell stage embryos, thereby triggering the occurrence of autophagy. In addition, exposure of PG altered the epigenetic modification of 2-cell stage em...
Source: Food and Chemical Toxicology - February 7, 2024 Category: Food Science Authors: Sheng-Ji Yang Fu-Yi Yang Yi-Nuo Zou Yong-Sheng Wang Zhi-Ming Ding Li-Dan Zhang Xu Zhou Ming Liu Ze-Qun Duan Li-Jun Huo Source Type: research
Microorganism-mediated bioremediation of dyes from contaminated soil: Mechanisms, recent advances, and future perspectives
Food Chem Toxicol. 2024 Feb 5;185:114491. doi: 10.1016/j.fct.2024.114491. Online ahead of print.ABSTRACTMany methods have been proposed for the remediation of dye-contaminated soils, a widespread form of environment pollution. Bioremediation, it is hoped, can combine ecological benefits with efficiency of dye decontamination. We review the types and sources of dye contaminants; their possible effects on plant, animal, and human health; and emerging strategies for microbial bioremediation. Challenges, limitations, recommendations for future research, and prospects for large-scale commercialization of microbial bioremediatio...
Source: Food and Chemical Toxicology - February 7, 2024 Category: Food Science Authors: A Saravanan P R Yaashikaa B Ramesh Alan Shaji V C Deivayanai Source Type: research
Update to RIFM fragrance ingredient safety assessment, methyl benzoate, CAS Registry Number 93-58-3
Food Chem Toxicol. 2024 Feb 5;183 Suppl 1:114493. doi: 10.1016/j.fct.2024.114493. Online ahead of print.NO ABSTRACTPMID:38325635 | DOI:10.1016/j.fct.2024.114493 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - February 7, 2024 Category: Food Science Authors: A M Api A Bartlett D Belsito D Botelho M Bruze A Bryant-Freidrich G A Burton M A Cancellieri H Chon M L Dagli W Dekant C Deodhar K Farrell A D Fryer L Jones K Joshi A Lapczynski M Lavelle I Lee H Moustakas J Muldoon T M Penning G Ritacco N Sadekar I Schem Source Type: research
RIFM fragrance ingredient safety assessment, cyclohexane, 1-(1,1-dimethylpropyl)-4-ethoxy-, cis-, CAS Registry Number 181258-87-7
Food Chem Toxicol. 2024 Feb 5;183 Suppl 1:114495. doi: 10.1016/j.fct.2024.114495. Online ahead of print.NO ABSTRACTPMID:38325636 | DOI:10.1016/j.fct.2024.114495 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - February 7, 2024 Category: Food Science Authors: A M Api A Bartlett D Belsito D Botelho M Bruze A Bryant-Freidrich G A Burton M A Cancellieri H Chon M L Dagli W Dekant C Deodhar K Farrell A D Fryer L Jones K Joshi A Lapczynski M Lavelle I Lee H Moustakas J Muldoon T M Penning G Ritacco N Sadekar I Schem Source Type: research
Bottled water safety evaluation: A comprehensive health risk assessment of oral exposure to heavy metals through deterministic and probabilistic approaches by Monte Carlo simulation
This study aimed to quantitatively evaluate the concentrations of eight heavy metals (As, Ba, Cd, Cr, Mn, Mo, Ni, and Zn) in 71 high-consumption bottled water brands in Iran. Non-carcinogenic and carcinogenic risk assessments were conducted using both deterministic and probabilistic approaches. Point estimation utilizing the Hazard Quotient (HQ) formula and sensitivity analysis employing the Monte Carlo Simulation (MCS) method through 10,000 repetitions in Oracle Crystal Ball® was used to ascertain the health risks associated with heavy metal exposure. Heavy metal concentrations were quantified through Inductively Coupled...
Source: Food and Chemical Toxicology - February 7, 2024 Category: Food Science Authors: Masoomeh Askari Hamed Soleimani Kamal Babakrpur Nalosi Reza Saeedi Samaneh Abolli Maryam Ghani Mehrnoosh Abtahi Mahmood Alimohammadi Source Type: research
