Propyl gallate exposure affects the mouse 2-cell stage embryonic development through inducing oxidative stress and autophagy

In this study, we explored the toxic effects and potential mechanisms of PG on mouse 2-cell stage embryonic development. The results showed that exposure of PG can decrease the development of 2-cell stage embryos and repress the development of 4-cell stage embryos. Further study found that PG could induce intracellular oxidative stress and the accumulation of DNA damage in 2-cell stage embryos. Moreover, exposure of PG impaired the function of mitochondria and lysosomes in 2-cell stage embryos, thereby triggering the occurrence of autophagy. In addition, exposure of PG altered the epigenetic modification of 2-cell stage embryos, displaying a decreased level of DNA methylation and an increased level of H3K4me3. In summary, our results indicated that exposure of PG can damage the development of mouse 2-cell stage embryos by inducing oxidative stress, DNA damage, and autophagy, and altering epigenetic modification.PMID:38325633 | DOI:10.1016/j.fct.2024.114488

Source: Food and Chemical Toxicology - February 7, 2024 Category: Food Science Authors: Sheng-Ji Yang Fu-Yi Yang Yi-Nuo Zou Yong-Sheng Wang Zhi-Ming Ding Li-Dan Zhang Xu Zhou Ming Liu Ze-Qun Duan Li-Jun Huo Source Type: research