Effects of trichlorobisphenol A on the expression of proteins and genes associated with puberty initiation in GT1-7 cells and the relevant molecular mechanism
This study evaluated the effects of Cl3BPA on kisspeptin-G-protein coupled receptor 54 (GPR54)/gonadotropin-releasing hormone (GnRH) (KGG) signals and analyzed the roles of estrogen receptor alpha (ERɑ) and G-protein coupled estrogen receptor 1 (GPER1) in regulating KGG signals. The results showed that Cl3BPA at 50 μM increased levels of intracellular reactive oxygen species (ROS) and GnRH, upregulated the protein levels of kisspeptin and the expression of fshr, lhr and gnrh1 genes related to KGG in GT1-7 cells. In addition, 50 μM Cl3BPA significantly upregulated the phosphorylation of extracellular regulated protein ki...
Source: Food and Chemical Toxicology - December 1, 2023 Category: Food Science Authors: Yingxin Yang Lanbing Xu Bingli Lei Yaoyao Huang Mengjie Yu Source Type: research
RIFM fragrance ingredient safety assessment, 3-ethyl-2,6-dimethylpyrazine, CAS Registry Number 13925-07-0
Food Chem Toxicol. 2023 Nov 29:114266. doi: 10.1016/j.fct.2023.114266. Online ahead of print.NO ABSTRACTPMID:38040239 | DOI:10.1016/j.fct.2023.114266 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - December 1, 2023 Category: Food Science Authors: A M Api D Belsito D Botelho M Bruze G A Burton M A Cancellieri H Chon M L Dagli W Dekant C Deodhar A D Fryer L Jones K Joshi M Kumar A Lapczynski M Lavelle I Lee D C Liebler H Moustakas J Muldoon T M Penning G Ritacco J Romine N Sadekar T W Schultz D Sele Source Type: research
Bisphenol a alternatives suppress human and rat aromatase activity: QSAR structure-activity relationship and in silico docking analysis
In conclusion, BPA alternatives can inhibit human and rat CYP19A1 and the lipophilicity and the substituted alkyl size determines their inhibitory strength.PMID:38040240 | DOI:10.1016/j.fct.2023.114257 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - December 1, 2023 Category: Food Science Authors: Miaomiao Xia Jingyi Zheng Sailin Chen Yunbing Tang Shaowei Wang Zhongyao Ji Ting Hao Huitao Li Linxi Li Ren-Shan Ge Yi Liu Source Type: research
RIFM fragrance ingredient safety assessment, geranyl isobutyrate, CAS Registry Number 2345-26-8
Food Chem Toxicol. 2023 Nov 30:114271. doi: 10.1016/j.fct.2023.114271. Online ahead of print.NO ABSTRACTPMID:38040241 | DOI:10.1016/j.fct.2023.114271 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - December 1, 2023 Category: Food Science Authors: A M Api D Belsito D Botelho M Bruze G A Burton M A Cancellieri H Chon M L Dagli M Date W Dekant C Deodhar A D Fryer L Jones K Joshi M Kumar A Lapczynski M Lavelle I Lee D C Liebler H Moustakas M Na T M Penning G Ritacco J Romine N Sadekar T W Schultz D Se Source Type: research
RIFM fragrance ingredient safety assessment, cyclohexanone,5-methyl-2-(1-methylethyl)-,oxime, CAS registry number 19096-86-7
Food Chem Toxicol. 2023 Nov 29:114272. doi: 10.1016/j.fct.2023.114272. Online ahead of print.NO ABSTRACTPMID:38040242 | DOI:10.1016/j.fct.2023.114272 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - December 1, 2023 Category: Food Science Authors: A M Api D Belsito D Botelho M Bruze G A Burton M A Cancellieri H Chon M L Dagli M Date W Dekant C Deodhar A D Fryer L Jones K Joshi M Kumar A Lapczynski M Lavelle I Lee D C Liebler H Moustakas M Na T M Penning G Ritacco J Romine N Sadekar T W Schultz D Se Source Type: research
RIFM fragrance ingredient safety assessment, 1,3-dimethyl-3-phenylbutyl acetate, CAS Registry Number 68083-58-9
Food Chem Toxicol. 2023 Nov 29:114264. doi: 10.1016/j.fct.2023.114264. Online ahead of print.NO ABSTRACTPMID:38040243 | DOI:10.1016/j.fct.2023.114264 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - December 1, 2023 Category: Food Science Authors: A M Api D Belsito D Botelho M Bruze G A Burton M A Cancellieri H Chon M L Dagli W Dekant C Deodhar A D Fryer L Jones K Joshi M Kumar A Lapczynski M Lavelle I Lee D C Liebler H Moustakas J Muldoon T M Penning G Ritacco J Romine N Sadekar T W Schultz D Sele Source Type: research
RIFM fragrance ingredient safety assessment, geranyl formate, CAS Registry Number 105-86-2
Food Chem Toxicol. 2023 Nov 29:114250. doi: 10.1016/j.fct.2023.114250. Online ahead of print.NO ABSTRACTPMID:38040244 | DOI:10.1016/j.fct.2023.114250 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - December 1, 2023 Category: Food Science Authors: A M Api D Belsito D Botelho M Bruze G A Burton M A Cancellieri H Chon M L Dagli M Date W Dekant C Deodhar A D Fryer L Jones K Joshi M Kumar A Lapczynski M Lavelle I Lee D C Liebler H Moustakas M Na T M Penning G Ritacco J Romine N Sadekar T W Schultz D Se Source Type: research
RIFM fragrance ingredient safety assessment, 2,5-dimethylpyrazine, CAS Registry Number 123-32-0
Food Chem Toxicol. 2023 Nov 28:114269. doi: 10.1016/j.fct.2023.114269. Online ahead of print.NO ABSTRACTPMID:38035978 | DOI:10.1016/j.fct.2023.114269 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - November 30, 2023 Category: Food Science Authors: A M Api D Belsito D Botelho M Bruze G A Burton M A Cancellieri H Chon M L Dagli W Dekant C Deodhar A D Fryer L Jones K Joshi M Kumar A Lapczynski M Lavelle I Lee D C Liebler H Moustakas M Na T M Penning G Ritacco J Romine N Sadekar T W Schultz D Selechnik Source Type: research
RIFM fragrance ingredient safety assessment, hexyl salicylate, CAS Registry Number 6259-76-3
Food Chem Toxicol. 2023 Nov 28:114217. doi: 10.1016/j.fct.2023.114217. Online ahead of print.NO ABSTRACTPMID:38035979 | DOI:10.1016/j.fct.2023.114217 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - November 30, 2023 Category: Food Science Authors: A M Api D Belsito D Botelho M Bruze G A Burton M A Cancellieri H Chon M L Dagli W Dekant C Deodhar A D Fryer L Jones K Joshi M Kumar A Lapczynski M Lavelle I Lee D C Liebler H Moustakas J Muldoon T M Penning G Ritacco J Romine N Sadekar T W Schultz D Sele Source Type: research
RIFM fragrance ingredient safety assessment, β-ionol, CAS Registry Number 22029-76-1
Food Chem Toxicol. 2023 Nov 28:114216. doi: 10.1016/j.fct.2023.114216. Online ahead of print.NO ABSTRACTPMID:38035980 | DOI:10.1016/j.fct.2023.114216 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - November 30, 2023 Category: Food Science Authors: A M Api D Belsito D Botelho M Bruze G A Burton M A Cancellieri H Chon M L Dagli W Dekant C Deodhar A D Fryer L Jones K Joshi M Kumar A Lapczynski M Lavelle I Lee D C Liebler H Moustakas J Muldoon T M Penning G Ritacco J Romine N Sadekar T W Schultz D Sele Source Type: research
RIFM fragrance ingredient safety assessment, 3,4-dihydro-5-methylnaphthalen-1(2H)-one, CAS Registry Number 6939-35-1
Food Chem Toxicol. 2023 Nov 28:114208. doi: 10.1016/j.fct.2023.114208. Online ahead of print.NO ABSTRACTPMID:38035981 | DOI:10.1016/j.fct.2023.114208 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - November 30, 2023 Category: Food Science Authors: A M Api D Belsito D Botelho M Bruze G A Burton M A Cancellieri H Chon M L Dagli W Dekant C Deodhar A D Fryer L Jones K Joshi M Kumar A Lapczynski M Lavelle I Lee D C Liebler H Moustakas J Muldoon T M Penning G Ritacco J Romine N Sadekar T W Schultz D Sele Source Type: research
RIFM fragrance ingredient safety assessment, 4-tert-butylcyclohexanol, CAS Registry Number 98-52-2
Food Chem Toxicol. 2023 Nov 28:114219. doi: 10.1016/j.fct.2023.114219. Online ahead of print.NO ABSTRACTPMID:38035982 | DOI:10.1016/j.fct.2023.114219 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - November 30, 2023 Category: Food Science Authors: A M Api D Belsito D Botelho M Bruze G A Burton M A Cancellieri H Chon M L Dagli W Dekant C Deodhar A D Fryer L Jones K Joshi M Kumar A Lapczynski M Lavelle I Lee D C Liebler H Moustakas J Muldoon T M Penning G Ritacco J Romine N Sadekar T W Schultz D Sele Source Type: research
RIFM fragrance ingredient safety assessment, ocimenol, CAS Registry Number 5986-38-9
Food Chem Toxicol. 2023 Nov 28:114207. doi: 10.1016/j.fct.2023.114207. Online ahead of print.NO ABSTRACTPMID:38035983 | DOI:10.1016/j.fct.2023.114207 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - November 30, 2023 Category: Food Science Authors: A M Api D Belsito D Botelho M Bruze G A Burton M A Cancellieri H Chon M L Dagli W Dekant C Deodhar A D Fryer L Jones K Joshi M Kumar A Lapczynski M Lavelle I Lee D C Liebler H Moustakas J Muldoon T M Penning G Ritacco J Romine N Sadekar T W Schultz D Sele Source Type: research
RIFM fragrance ingredient safety assessment, decahydro- β-naphthyl formate, CAS Registry Number 10519-12-7
Food Chem Toxicol. 2023 Nov 28:114249. doi: 10.1016/j.fct.2023.114249. Online ahead of print.NO ABSTRACTPMID:38035984 | DOI:10.1016/j.fct.2023.114249 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - November 30, 2023 Category: Food Science Authors: A M Api D Belsito D Botelho M Bruze G A Burton M A Cancellieri H Chon M L Dagli W Dekant C Deodhar A D Fryer L Jones K Joshi M Kumar A Lapczynski M Lavelle I Lee D C Liebler H Moustakas M Na T M Penning G Ritacco J Romine N Sadekar T W Schultz D Selechnik Source Type: research
RIFM fragrance ingredient safety assessment, butyl butyryllactate, CAS Registry Number 7492-70-8
Food Chem Toxicol. 2023 Nov 28:114268. doi: 10.1016/j.fct.2023.114268. Online ahead of print.NO ABSTRACTPMID:38035985 | DOI:10.1016/j.fct.2023.114268 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - November 30, 2023 Category: Food Science Authors: A M Api D Belsito D Botelho M Bruze G A Burton M A Cancellieri H Chon M L Dagli W Dekant C Deodhar A D Fryer L Jones K Joshi M Kumar A Lapczynski M Lavelle I Lee D C Liebler H Moustakas M Na T M Penning G Ritacco J Romine N Sadekar T W Schultz D Selechnik Source Type: research
