Study of ATF4/CHOP axis-mediated mitochondrial unfolded protein response in neuronal apoptosis induced by methylmercury
In this study, the role of the ATF4/CHOP axis-mediated UPRmt in the neurotoxicity of MeHg has been investigated by C57BL/6 mice and the HT22 cell line. We discovered that mice exposed to MeHg had abnormal neurobehavioral patterns. The pathological section showed a significant decrease in the number of neurons. MeHg also resulted in a reduction in mtDNA copy number and mitochondrial membrane potential (MMP). Additionally, the ATF4/CHOP axis and UPRmt were found to be significantly activated. Subsequently, we used siRNA to knock down ATF4 or CHOP and observed that the expression of UPRmt-related proteins and the apoptosis ra...
Source: Food and Chemical Toxicology - November 15, 2023 Category: Food Science Authors: Si Xu Haihui Liu Chen Wang Yu Deng Bin Xu Tianyao Yang Wei Liu Source Type: research
Deficiency of aldehyde dehydrogenase 2 aggravates ethanol-induced cytotoxicity in N2a cells via CaMKII/Drp1-mediated mitophagy
Food Chem Toxicol. 2023 Nov 13:114129. doi: 10.1016/j.fct.2023.114129. Online ahead of print.ABSTRACTChronic alcohol abuse causes brain damage and has been associated with an increased risk of Alzheimer's disease. The toxic metabolite of alcohol, acetaldehyde, which is converted to acetate by aldehyde dehydrogenase 2 (ALDH2), has been shown to induce excessive mitochondrial fragmentation and dysfunction leading to neurotoxicity. However, it is still unclear how alcohol affects mitochondrial function in ALDH2-deficient cells. The present study investigated the association between abnormal mitochondrial dynamics, mitophagy a...
Source: Food and Chemical Toxicology - November 15, 2023 Category: Food Science Authors: Tingting Yan Jiyang Chen Yalin Wang Yinuo Wang Yuanqingzhi Zhang Yan Zhao Source Type: research
Integrated untargeted and targeted proteomics to unveil plasma prognostic markers for patients with acute paraquat poisoning: A pilot study
Food Chem Toxicol. 2023 Nov 13:114187. doi: 10.1016/j.fct.2023.114187. Online ahead of print.ABSTRACTParaquat (PQ) is a widely used but strongly toxic herbicide, which can induce multiple organ failure. The overall survival rate of the poisoned patients was only 54.4% due to lack of specific antidotes. Besides, the definite pathogenic mechanism of PQ is still not fully understood. In this pilot study, untargeted and targeted proteomics were integrated to explore the expression characteristics of plasma protein in PQ poisoned patients, and identify the differentially expressed proteins between survivors and non-survivors. A...
Source: Food and Chemical Toxicology - November 15, 2023 Category: Food Science Authors: Tianqi Zhang Siqi Huang Min Wang Na Yang Huaijun Zhu Source Type: research
Transcriptomic characterization of interactions between sodium selenite and coenzyme Q10 on preventing cadmium-induced testicular defects
In conclusion, Cd exposure inhibited Leydig cell steroidogenesis by down-regulating SCARB1 and STAR through increasing oxidative stress and inflammation, but Se plus CoQ synergistically prevented all the changes induced by the Cd exposure.PMID:37967787 | DOI:10.1016/j.fct.2023.114180 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - November 15, 2023 Category: Food Science Authors: Jiajia Xie Jiexia Wang Jingjing Shao Hangping Fang Yijia Liu Xue Xiao Xin Wen Xiaoju Guan Zhijian Su Ping Duan Haolin Chen Congde Chen Source Type: research
Combined exposure to multiwalled carbon nanotubes and dibutyl phthalates aggravated airway inflammation in rats
Food Chem Toxicol. 2023 Nov 13:114188. doi: 10.1016/j.fct.2023.114188. Online ahead of print.ABSTRACTPrevious work has shown that mice exposed to dibutyl phthalate (DBP) adsorbed onto multi-walled carbon nanotubes (MWCNTs), via tail vein injection, displayed black lesions in their lungs. To investigate the mechanism causing this toxicity in the lung tissue, we performed an experiment with rats, exposing them to DBP adsorbed onto MWCNTs via a tail vein injection for 14 days. The results revealed pulmonary edema and greyish-black lung tissue in the MWCNTs and the MWCNTs + DBP combined exposure groups. In the combined exposur...
Source: Food and Chemical Toxicology - November 15, 2023 Category: Food Science Authors: Suli He Haiyan Peng Min Wu Chao Yan Jian Wan Xin Ye Hongmao Zhang Shumao Ding Source Type: research
Study of ATF4/CHOP axis-mediated mitochondrial unfolded protein response in neuronal apoptosis induced by methylmercury
In this study, the role of the ATF4/CHOP axis-mediated UPRmt in the neurotoxicity of MeHg has been investigated by C57BL/6 mice and the HT22 cell line. We discovered that mice exposed to MeHg had abnormal neurobehavioral patterns. The pathological section showed a significant decrease in the number of neurons. MeHg also resulted in a reduction in mtDNA copy number and mitochondrial membrane potential (MMP). Additionally, the ATF4/CHOP axis and UPRmt were found to be significantly activated. Subsequently, we used siRNA to knock down ATF4 or CHOP and observed that the expression of UPRmt-related proteins and the apoptosis ra...
Source: Food and Chemical Toxicology - November 15, 2023 Category: Food Science Authors: Si Xu Haihui Liu Chen Wang Yu Deng Bin Xu Tianyao Yang Wei Liu Source Type: research
Hormonal residues in chicken and cattle meat: A risk threat the present and future consumer health
Food Chem Toxicol. 2023 Nov 11:114172. doi: 10.1016/j.fct.2023.114172. Online ahead of print.ABSTRACTThe study was designated to determine some hormonal residues (estradiol, progesterone, and testosterone) in chicken and cattle meat as well as assess the risk of these residues for adult and child consumer health. A total of 92 chicken meat samples were collected from four different chicken farm sales outlets, and 56 cattle meat samples from two brands were collected from markets through 2022 in Assiut City, Egypt. An enzyme-linked immunosorbant assay (ELISA) was used to measure the hormonal residues. Results showed that th...
Source: Food and Chemical Toxicology - November 13, 2023 Category: Food Science Authors: Heba F Kamaly Ahmed A Sharkawy Source Type: research
Update to RIFM fragrance ingredient safety assessment, ethylene dodecanedioate, CAS Registry Number 54982-83-1
Food Chem Toxicol. 2023 Nov 11:114138. doi: 10.1016/j.fct.2023.114138. Online ahead of print.NO ABSTRACTPMID:37956706 | DOI:10.1016/j.fct.2023.114138 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - November 13, 2023 Category: Food Science Authors: A M Api D Belsito D Botelho M Bruze G A Burton M A Cancellieri H Chon M L Dagli W Dekant C Deodhar A D Fryer L Jones K Joshi M Kumar A Lapczynski M Lavelle I Lee D C Liebler H Moustakas J Muldoon T M Penning G Ritacco J Romine N Sadekar T W Schultz D Sele Source Type: research
Role of MRPs transporters in pharmacokinetics and intestinal toxicity of irinotecan
Food Chem Toxicol. 2023 Nov 11:114171. doi: 10.1016/j.fct.2023.114171. Online ahead of print.ABSTRACTTo identify additional genetic markers contributing to variability in CPT-11 disposition and toxicity, we assessed impact of the multiple drug-resistant transporters 1, 2, and 3 (MRP1, MRP2, and MRP3) on the intestinal toxicity, pharmacokinetics, tissue distribution and biliary excretion of CPT-11 using a knockout mouse model. Mrp1/3 knockout had minor impact on intestinal toxicity of CPT-11, tissue distribution, biliary excretion, and PK parameter of its active metabolites SN38. Conversely, Mrp2-/- mice, with low carboxyle...
Source: Food and Chemical Toxicology - November 13, 2023 Category: Food Science Authors: Ting Du Tao Luo Junwen Wang Rongjin Sun Hua Cai Source Type: research
Hormonal residues in chicken and cattle meat: A risk threat the present and future consumer health
Food Chem Toxicol. 2023 Nov 11:114172. doi: 10.1016/j.fct.2023.114172. Online ahead of print.ABSTRACTThe study was designated to determine some hormonal residues (estradiol, progesterone, and testosterone) in chicken and cattle meat as well as assess the risk of these residues for adult and child consumer health. A total of 92 chicken meat samples were collected from four different chicken farm sales outlets, and 56 cattle meat samples from two brands were collected from markets through 2022 in Assiut City, Egypt. An enzyme-linked immunosorbant assay (ELISA) was used to measure the hormonal residues. Results showed that th...
Source: Food and Chemical Toxicology - November 13, 2023 Category: Food Science Authors: Heba F Kamaly Ahmed A Sharkawy Source Type: research
Update to RIFM fragrance ingredient safety assessment, ethylene dodecanedioate, CAS Registry Number 54982-83-1
Food Chem Toxicol. 2023 Nov 11:114138. doi: 10.1016/j.fct.2023.114138. Online ahead of print.NO ABSTRACTPMID:37956706 | DOI:10.1016/j.fct.2023.114138 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - November 13, 2023 Category: Food Science Authors: A M Api D Belsito D Botelho M Bruze G A Burton M A Cancellieri H Chon M L Dagli W Dekant C Deodhar A D Fryer L Jones K Joshi M Kumar A Lapczynski M Lavelle I Lee D C Liebler H Moustakas J Muldoon T M Penning G Ritacco J Romine N Sadekar T W Schultz D Sele Source Type: research
Role of MRPs transporters in pharmacokinetics and intestinal toxicity of irinotecan
Food Chem Toxicol. 2023 Nov 11:114171. doi: 10.1016/j.fct.2023.114171. Online ahead of print.ABSTRACTTo identify additional genetic markers contributing to variability in CPT-11 disposition and toxicity, we assessed impact of the multiple drug-resistant transporters 1, 2, and 3 (MRP1, MRP2, and MRP3) on the intestinal toxicity, pharmacokinetics, tissue distribution and biliary excretion of CPT-11 using a knockout mouse model. Mrp1/3 knockout had minor impact on intestinal toxicity of CPT-11, tissue distribution, biliary excretion, and PK parameter of its active metabolites SN38. Conversely, Mrp2-/- mice, with low carboxyle...
Source: Food and Chemical Toxicology - November 13, 2023 Category: Food Science Authors: Ting Du Tao Luo Junwen Wang Rongjin Sun Hua Cai Source Type: research
Hormonal residues in chicken and cattle meat: A risk threat the present and future consumer health
Food Chem Toxicol. 2023 Nov 11:114172. doi: 10.1016/j.fct.2023.114172. Online ahead of print.ABSTRACTThe study was designated to determine some hormonal residues (estradiol, progesterone, and testosterone) in chicken and cattle meat as well as assess the risk of these residues for adult and child consumer health. A total of 92 chicken meat samples were collected from four different chicken farm sales outlets, and 56 cattle meat samples from two brands were collected from markets through 2022 in Assiut City, Egypt. An enzyme-linked immunosorbant assay (ELISA) was used to measure the hormonal residues. Results showed that th...
Source: Food and Chemical Toxicology - November 13, 2023 Category: Food Science Authors: Heba F Kamaly Ahmed A Sharkawy Source Type: research
Update to RIFM fragrance ingredient safety assessment, ethylene dodecanedioate, CAS Registry Number 54982-83-1
Food Chem Toxicol. 2023 Nov 11:114138. doi: 10.1016/j.fct.2023.114138. Online ahead of print.NO ABSTRACTPMID:37956706 | DOI:10.1016/j.fct.2023.114138 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - November 13, 2023 Category: Food Science Authors: A M Api D Belsito D Botelho M Bruze G A Burton M A Cancellieri H Chon M L Dagli W Dekant C Deodhar A D Fryer L Jones K Joshi M Kumar A Lapczynski M Lavelle I Lee D C Liebler H Moustakas J Muldoon T M Penning G Ritacco J Romine N Sadekar T W Schultz D Sele Source Type: research
Role of MRPs transporters in pharmacokinetics and intestinal toxicity of irinotecan
Food Chem Toxicol. 2023 Nov 11:114171. doi: 10.1016/j.fct.2023.114171. Online ahead of print.ABSTRACTTo identify additional genetic markers contributing to variability in CPT-11 disposition and toxicity, we assessed impact of the multiple drug-resistant transporters 1, 2, and 3 (MRP1, MRP2, and MRP3) on the intestinal toxicity, pharmacokinetics, tissue distribution and biliary excretion of CPT-11 using a knockout mouse model. Mrp1/3 knockout had minor impact on intestinal toxicity of CPT-11, tissue distribution, biliary excretion, and PK parameter of its active metabolites SN38. Conversely, Mrp2-/- mice, with low carboxyle...
Source: Food and Chemical Toxicology - November 13, 2023 Category: Food Science Authors: Ting Du Tao Luo Junwen Wang Rongjin Sun Hua Cai Source Type: research
