Butylated hydroxyanisole induces vascular endothelial injury via TFEB-mediated degradation of GPX4 and FTH1

In conclusion, BHA degrades GPX4, xCT, and FTH1 through activation of the TFEB-mediated lysosomal pathway and promotes ferroptosis, ultimately leading to vascular endothelial cell injury.PMID:38657941 | DOI:10.1016/j.fct.2024.114682
Source: Food and Chemical Toxicology - Category: Food Science Authors: Source Type: research