Fight Aging! Newsletter, April 22nd 2024
This study reveals a potential treatment for human mitochondrial diseases.
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A Population Study Correlates Air Pollution with Faster Cognitive Aging
https://www.fightaging.org/archives/2024/04/a-population-study-correlates-air-pollution-with-faster-cognitive-aging/
A number of large epidemiological studies provide evidence for long-term exposure to greater levels of air pollution to accelerate the onset and progression of age-related disease. A few of these manage to control for the tendency for wealthier people to avoid living in areas with higher particulate air pollution, ...
Source: Fight Aging! - April 21, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Considering Cellular Senescence in Macrophages
Cells become senescent in response to damage, a toxic environment, the signaling of nearby senescent cells, or, most commonly, because they reach the Hayflick limit on replication. Senescent cells cease replication and begin to secrete pro-inflammatory signals, attracting the attention of the immune system. With advancing age he aged immune system becomes less able to clear senescent cells in a timely manner, leading to a growing, permanent presence of senescent cells in tissues. Some of these senescent cells are themselves immune cells. Given the importance of the immune system to tissue maintenance and regeneration, part...
Source: Fight Aging! - April 16, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Research Organism Superheroes: Axolotls
The friendly-looking axolotl (Ambystoma mexicanum) doesn’t seem to have much in common with its namesake, Xolotl—the Aztec god of lightning, death, and fire. In fact, axolotls can regrow lost limbs and other body parts like organs and parts of their central nervous systems—which goes against the concept of death!
The axolotl can regenerate almost any body part, including brain, heart, jaws, limbs, lungs, ovaries, spinal cord, skin, and tail. This ability makes it an excellent research organism to study in the search for regenerative medicine. Credit: Marko Pende, MDI Biological Laboratory; MDI Biological Labor...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - March 6, 2024 Category: Research Authors: Chrissa Chverchko Tags: STEM Education Tools and Techniques Coloring Pages Cool Creatures Regeneration Research Organisms Source Type: blogs
Digital Health, Menopause, And The $150 Billion Ignorance
The idea of this story came from personal experience. During the past year, I have spent countless hours and a bucketload of money trying to figure out what the heck is wrong with my health. I was feeling worse and worse, having various symptoms, totally inexplicable with my impeccable test results. During this journey, not a single doctor asked or suggested that my symptoms may come from entering perimenopause – the stage of life of women preceding menopause.
I am 47 years old, and as I have learned since then, extremely average in starting to have perimenopause symptoms at the age of 47. Also very average ...
Source: The Medical Futurist - February 22, 2024 Category: Information Technology Authors: Andrea Koncz Tags: TMF Lifestyle medicine female health menopause tech Source Type: blogs
Fight Aging! Newsletter, January 22nd 2024
In this study, we found that DMC reduced the SASP level in senescent cells. Furthermore, senescent cells enter irreversible cell cycle arrest, which involves the activation of p53/p21 and Rb/p16. In this study we found that the expression levels of p21 and p16 were decreased after DMC treatment. The downregulation of p21 may be attributed to the decrease of p53. In this study, we found that the mRNA level of p53 was reduced after DMC treatment.
Ferroptosis is an iron-dependent cell death process, which is accompanied by iron accumulation. Our previous study reported an important role of FECH, an enzyme inserts ferro...
Source: Fight Aging! - January 21, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Role for the Gut Microbiome in the Aging of the Ovaries
As is the case for the thymus, aging and loss of function in the ovaries is interesting for (a) occurring at an accelerated pace relative to the rest of the body, and (b) producing meaningful downstream consequences in later life. What causes this comparatively early loss of function? Here, researchers look at changes in the balance of microbial populations in the gut microbiome as a contributing factor. The gut microbiome also shows age-related changes comparatively early in adult life, in which pro-inflammatory microbes expand in number whilst those producing beneficial metabolites decline in number.
Altered com...
Source: Fight Aging! - January 16, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, January 15th 2024
In conclusion, FMD cycles have high potential to be effective in increasing the toxicity of a range of therapies against ALL and other blood cancers and should be tested in randomized clinical trials, especially in combination with immunotherapy and low toxicity cancer therapies.
In summary, we present a new strategy for improving leukemia treatment by combining FMD with chemotherapy to promote the killing of ALL cells in part by an immune-dependent mechanism. Fasting/FMD has been shown to reduce chemotherapy-associated toxicity in pre-clinical and clinical studies and thus represents a safe and potentially effectiv...
Source: Fight Aging! - January 14, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Continued Assessment of the Fasting Mimicking Diet as an Adjuvant Cancer Therapy
In conclusion, FMD cycles have high potential to be effective in increasing the toxicity of a range of therapies against ALL and other blood cancers and should be tested in randomized clinical trials, especially in combination with immunotherapy and low toxicity cancer therapies.
In summary, we present a new strategy for improving leukemia treatment by combining FMD with chemotherapy to promote the killing of ALL cells in part by an immune-dependent mechanism. Fasting/FMD has been shown to reduce chemotherapy-associated toxicity in pre-clinical and clinical studies and thus represents a safe and potentially effectiv...
Source: Fight Aging! - January 12, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, January 1st 2024
Discussion of What is Need to Speed the Pace at which Drugs to Treat Aging Arrive in the Clinic
Cellular Senescence in the Aging Brain, a Contributing Cause of Cognitive Decline
Reviewing What is Known of the Mechanisms of Taurine Supplementation Relevant to Aging and Metabolism
Blunt Thoughts on Calculating the Revealed Value of Human Life
A Look Back at 2023: Progress Towards the Treatment of Aging as a Medical Condition
Towards Adjustment of the Gut Microbiome to Slow Aging
Gene Therapy Enhances Object Recognition Memory in Young and Old Mice
Benefits of Sem...
Source: Fight Aging! - December 31, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
CD38 in Ovarian Aging
The ovaries, like the thymus, are interesting for their comparatively early exhibition of age-related degeneration. Is there anything useful that can be learned about aging more generally by looking at the portions of the body that experience aging more rapidly? That remains to be seen. Here, researchers investigate NAD+ metabolism in the ovaries versus other tissues, noting that CD38, an enzyme that removes NAD+, is more active earlier in life. Approaches to maintain NAD+ levels slow ovarian aging, including knocking out CD38.
Delayed childbearing is prevalent worldwide, and ovarian senescence occurs earlier than...
Source: Fight Aging! - December 29, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, October 30th 2023
In conclusion, reported adherence to a healthy lifestyle is associated with reduced risk of all-cause and cause-specific mortality. Adherence to all four lifestyle factors resulted in the strongest protection.
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Source: Fight Aging! - October 29, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Microfluidic System Incorporates Eight Organ Tissues for Drug Testing
Researchers at Northwestern University have developed a sophisticated microfluidic system that incorporates tissue from up to eight different organ systems. The technology is unprecedented in allowing researchers to study complex interactions between different organs during disease. Moreover, it also allows for more comprehensive drug testing that investigates the effects of drug candidates on multiple organ systems at once. Called Lattice, the system is a significant advancement over pre-existing in vitro systems, which typically only allow researchers to study two organ tissues at once. The entire system fits into a spac...
Source: Medgadget - October 26, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Materials Medicine northwestern Source Type: blogs
Sex Differences in Cholinergic Neurons in the Context of Alzheimer's Disease
Why are most Alzheimer's disease patients women? The longer female life expectancy is not enough to explain all of this difference, so researchers investigate the underlying biochemical differences between sexes in search of an explanation. The goal is to use this difference in outcomes to identify mechanisms that are important to disease progression in all humans. One might look at a recent paper on microglial biochemistry, for example, and compare with this examination of the activity of cholinergic neurons. It is worth noting that the two are linked, with cholinergic neurons likely regulating microglial behavior to some...
Source: Fight Aging! - October 24, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Reviewing the Aging of the Ovaries
The ovaries, like the thymus, undergo a form of degenerative aging that occurs somewhat in advance of the aging of other parts of the body. It leads to the phenomenon of menopause and subsequent consequences to health and function, which, interestingly, is a feature of aging that is shared with only a few other mammalian species. That makes the ovaries and their surrounding tissues an interesting target for the development of ways to slow or reverse loss of function. Maintained ovarian function may prove to modestly slow aging in older women; it is a reasonable hypothesis and goal to pursue given what is known of the inter...
Source: Fight Aging! - October 17, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Career Conversations: Q & A With Physiologist Elimelda Moige Ongeri
Credit: Courtesy of Dr. Elimelda Moige Ongeri.
A career path in science is rarely clear cut and linear, which Elimelda Moige Ongeri, Ph.D., can attest adds to its excitement. She went from working in animal reproductive biology to studying proteins involved in inflammation and tissue injury. Dr. Ongeri is also currently dean of the Hairston College of Health and Human Sciences and professor of physiology at North Carolina Agricultural and Technical State University (NC A&T) in Greensboro. In this interview, she shares details of her career, including a change in research focus to human physiology; her goals for the f...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - June 14, 2023 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Profiles Proteins Source Type: blogs
