Mismatch repair deficiency and abnormal p53 expression has significant predictive value for progesterone resistance and endometrial tumorigenesis in patients with endometrial atypical hyperplasia receiving fertility-preserving treatment

CONCLUSIONS: EAH patients with MMR-d and p53abn have a significantly higher risk of disease relapse and progression. Thus, MMR-d and p53abn may be used as predictive biomarkers of progestin resistance and endometrial tumorigenesis in EAH.PMID:38691985 | DOI:10.1016/j.ygyno.2024.04.013

Source: Gynecologic Oncology - May 1, 2024 Category: Cancer & Oncology Authors: Hongfa Peng Jingjing Jiang Limeng Li Zengfang Hao Hongguang Lian Hui Du Wei Wang Source Type: research