Risk factors for poor neonatal outcome in pregnancies with decreased fetal movements
ConclusionsThe highest incidence of poor neonatal outcome among women with reduced fetal movement was found in the groups with small for gestational age fetuses in nulliparous and multiparous women. A routine ultrasound assessment for fetal growth in third trimester is supposedly most efficient to identify undiagnosed small for gestational age. (Source: Acta Obstetricia et Gynecologica Scandinavica)
Source: Acta Obstetricia et Gynecologica Scandinavica - February 20, 2020 Category: OBGYN Authors: Irene Sterpu, Christina Pilo, Ina Schuppe Koistinen, Pelle G Lindqvist, Kristina Gemzell ‐Danielsson, Eva Wiberg Itzel Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Risk of adverse pregnancy outcomes of late ‐ and postterm pregnancies in advanced maternal age: a national cohort study
ConclusionsThe risk of adverse pregnancy outcome increases with advancing maternal age. Women aged ≥40, have an increased risk of adverse perinatal and maternal outcome when pregnancy goes beyond 41 weeks. Gestational age was more strongly associated with adverse perinatal and maternal outcomes than maternal age, but the difference was non‐significant. (Source: Acta Obstetricia et Gynecologica Scandinavica)
Source: Acta Obstetricia et Gynecologica Scandinavica - February 20, 2020 Category: OBGYN Authors: Joep C. Kortekaas, Brenda M. Kazemier, Judit K.J. Keulen, Aafke Bruinsma, Ben Willem Mol, Frank Vandenbussche, Jeroen Van Dillen, Esteriek De Miranda Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Reduced fetal movements at term in singleton low risk pregnancies —Is there an association with placental histopathological findings?
AbstractIntroductionMaternal perception of fetal movements has long been considered an indicator of fetal well ‐being. A sudden decrease in the number of fetal movements is suggestive of fetal compromise. We aimed to determine whether the maternal perception of reduced fetal movements (RFM) is associated with placental pathological lesions in a low‐risk term population.Material and methodsOur study was a case ‐control study that was performed in a single university center. Placental histopathology, maternal demographics, labor characteristics, and neonatal outcomes of term, singleton pregnancies with maternal percept...
Source: Acta Obstetricia et Gynecologica Scandinavica - February 16, 2020 Category: OBGYN Authors: Michal Levy, Michal Kovo, Yakira Izaik, Isca Luwisch Cohen, Letizia Schreiber, Hadas Ganer Herman, Giulia Barda, Jacob Bar, Eran Weiner Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Fibrin lysability is associated with central obesity and inflammation in women with polycystic ovary syndrome
AbstractIntroductionPolycystic ovary syndrome (PCOS) is characterized by increased central fat mass (CFM), hyper ‐inflammation and hemostatic alterations, and the risk of cardiovascular disease could be increased. Reduced fibrin lysability is a risk factor for cardiovascular disease. The present study assessed fibrin lysability in women with PCOS and controls of similar age and body mass index.Material and methodsNinety women with PCOS and 35 controls of comparable age and body mass index were included. Hemostatic markers (fibrin lysability, fibrinogen, coagulation factor XIII, plasminogen, plasminogen activator inhibito...
Source: Acta Obstetricia et Gynecologica Scandinavica - February 15, 2020 Category: OBGYN Authors: Anne Cathrine Meldgaard Godtfredsen, Johannes Jakobsen Sidelmann, J ørgen Brodersen Gram, Marianne Andersen, Dorte Glintborg Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Feasibility and safety of two different surgical routes for the eradication of recto ‐vaginal endometriosis with vaginal mucosa infiltration (Endo‐Vag‐r study)
ConclusionsIn women affected by recto ‐vaginal endometriosis with vaginal mucosal infiltration, perioperative outcomes seem not to be influenced by the surgical route adopted. (Source: Acta Obstetricia et Gynecologica Scandinavica)
Source: Acta Obstetricia et Gynecologica Scandinavica - February 15, 2020 Category: OBGYN Authors: Diego Raimondo, Luigi Carlo Turco, Francesco Cosentino, Mohamed Mabrouk, Manuela Mastronardi, Giulia Borghese, Ilaria Giaquinto, Virginia Vargiu, Anna Fagotti, Maria Cristina Meriggiola, Vito Chiantera, Giovanni Scambia, Renato Seracchioli Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Risk ‐factors for continuous long‐term use of prescription opioid drugs three years after hysterectomy; a nationwide cohort study
ConclusionsLong ‐term use of prescription opioids after hysterectomy is common and is, among other risk‐factors, strongly associated with preoperative use of opioids, as well as, psychoactive drugs and adenomyosis. To avoid opioid misuse disorders among women at risk for long‐term opioid drug prescriptions af ter hysterectomy further studies and strategies are needed. (Source: Acta Obstetricia et Gynecologica Scandinavica)
Source: Acta Obstetricia et Gynecologica Scandinavica - February 15, 2020 Category: OBGYN Authors: Malin Brunes, Henrike H äbel, Daniel Altman, Marion Ek Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Reduced fetal movements at term in singleton low risk pregnancies —Is there an association with placental histopathological findings?
AbstractIntroductionMaternal perception of fetal movements has long been considered an indicator of fetal well ‐being. A sudden decrease in the number of fetal movements is suggestive of fetal compromise. We aimed to determine whether the maternal perception of reduced fetal movements (RFM) is associated with placental pathological lesions in a low‐risk term population.Material and methodsOur study was a case ‐control study that was performed in a single university center. Placental histopathology, maternal demographics, labor characteristics, and neonatal outcomes of term, singleton pregnancies with maternal percept...
Source: Acta Obstetricia et Gynecologica Scandinavica - February 15, 2020 Category: OBGYN Authors: Michal Levy, Michal Kovo, Yakira Izaik, Isca Luwisch Cohen, Letizia Schreiber, Hadas Ganer Herman, Giulia Barda, Jacob Bar, Eran Weiner Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Risk ‐factors for continuous long‐term use of prescription opioid drugs three years after hysterectomy; a nationwide cohort study
ConclusionsLong ‐term use of prescription opioids after hysterectomy is common and is, among other risk‐factors, strongly associated with preoperative use of opioids, as well as, psychoactive drugs and adenomyosis. To avoid opioid misuse disorders among women at risk for long‐term opioid drug prescriptions af ter hysterectomy further studies and strategies are needed. (Source: Acta Obstetricia et Gynecologica Scandinavica)
Source: Acta Obstetricia et Gynecologica Scandinavica - February 14, 2020 Category: OBGYN Authors: Malin Brunes, Henrike H äbel, Daniel Altman, Marion Ek Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Feasibility and safety of two different surgical routes for the eradication of recto ‐vaginal endometriosis with vaginal mucosa infiltration (Endo‐Vag‐r study)
ConclusionsIn women affected by recto ‐vaginal endometriosis with vaginal mucosal infiltration, perioperative outcomes seem not to be influenced by the surgical route adopted. (Source: Acta Obstetricia et Gynecologica Scandinavica)
Source: Acta Obstetricia et Gynecologica Scandinavica - February 13, 2020 Category: OBGYN Authors: Diego Raimondo, Luigi Carlo Turco, Francesco Cosentino, Mohamed Mabrouk, Manuela Mastronardi, Giulia Borghese, Ilaria Giaquinto, Virginia Vargiu, Anna Fagotti, Maria Cristina Meriggiola, Vito Chiantera, Giovanni Scambia, Renato Seracchioli Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Fibrin lysability is associated with central obesity and inflammation in women with polycystic ovary syndrome
AbstractIntroductionPolycystic ovary syndrome (PCOS) is characterized by increased central fat mass (CFM), hyper ‐inflammation and hemostatic alterations, and the risk of cardiovascular disease could be increased. Reduced fibrin lysability is a risk factor for cardiovascular disease. The present study assessed fibrin lysability in women with PCOS and controls of similar age and body mass index.Material and methodsNinety women with PCOS and 35 controls of comparable age and body mass index were included. Hemostatic markers (fibrin lysability, fibrinogen, coagulation factor XIII, plasminogen, plasminogen activator inhibito...
Source: Acta Obstetricia et Gynecologica Scandinavica - February 12, 2020 Category: OBGYN Authors: Anne Cathrine Meldgaard Godtfredsen, Johannes Jakobsen Sidelmann, J ørgen Brodersen Gram, Marianne Andersen, Dorte Glintborg Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Diagnostic accuracy of repeat placental growth factor measurements in women with suspected preeclampsia: a case series study
AbstractIntroductionPreeclampsia affects about 3% of singleton pregnancies, and is characterised by placental dysfunction. It is associated with significant maternal and perinatal morbidity and mortality. The diagnosis of preeclampsia remains a challenge, and the clinical course can develop over weeks before a diagnosis is confirmed. National guidelines have approved placental growth factor (PlGF) testing to rule out suspected preeclampsia, but the utility of repeated PlGF measurement is unknown. The aim of this case series analysis was to evaluate the test performance of repeated PlGF sampling in women presenting with sus...
Source: Acta Obstetricia et Gynecologica Scandinavica - February 11, 2020 Category: OBGYN Authors: Kate E Duhig, Louise M Webster, Andrew Sharp, Carolyn Gill, Paul T Seed, Andrew H Shennan, Jenny E Myers, Lucy C Chappell Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Seasonal variation in the hypertensive disorders of pregnancy in Denmark
ConclusionsWe found a seasonal variation in the risk of the hypertensive disorders of pregnancy in a large cohort of Danish nulliparous women. The highest risk was seen in women with the estimated date of conception in June and August, that is, during summer. Seasonal variation in vitamin D status may explain this association. (Source: Acta Obstetricia et Gynecologica Scandinavica)
Source: Acta Obstetricia et Gynecologica Scandinavica - February 11, 2020 Category: OBGYN Authors: Christine Rohr Thomsen, Tine Brink Henriksen, Niels Uldbjerg, Ioanna Milidou Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

"It's probably nothing, but …" Couples' experiences of pregnancy following an uncertain prenatal genetic result
ConclusionsThe results indicate that health professionals should be mindful of terminology, remember to point out what has been ruled out by the CNV result, and discuss potential coping strategies with the couple. Furthermore, these couples may have a higher need for ultrasound during pregnancy to help reduce worry. More research is needed on the families' long ‐term coping. (Source: Acta Obstetricia et Gynecologica Scandinavica)
Source: Acta Obstetricia et Gynecologica Scandinavica - February 11, 2020 Category: OBGYN Authors: Stina Lou, Kirsten Lomborg, Celine Lewis, Sam Riedijk, Olav Bj ørn Petersen, Ida Vogel Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Short ‐term surgical complications after radical hysterectomy—A nationwide cohort study
ConclusionsShort ‐term surgical complications developed in 35% of the women after radical hysterectomy for early‐stage cervical cancer in the Netherlands, a nation with centralized surgical care. Comorbidities predict surgical complications, and open surgery is associated with excessive perioperative blood loss. (Source: Acta Obstetricia et Gynecologica Scandinavica)
Source: Acta Obstetricia et Gynecologica Scandinavica - February 11, 2020 Category: OBGYN Authors: Hans H. B. Wenzel, Roy F. P. M. Kruitwagen, Hans W. Nijman, Ruud L. M. Bekkers, Toon Gorp, Cornelis D. Kroon, Luc R. C. W. Lonkhuijzen, Leon F. A. G. Massuger, Ramon G. V. Smolders, Nienke E. Trommel, Refika Yigit, Ronald P. Zweemer, Maaike A. Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

The role of testosterone in menopausal hormone treatment. What is the evidence?
AbstractAbout 40% of postmenopausal women have decreased sexual desire causing distress. Estrogen therapy attenuates vaginal complaints, but has no effect on sexual desire. Although sexual function has been linked to testosterone, there is no clear relation between sexual desire and circulating levels of testosterone. Nevertheless, treatment with transdermal (patch) testosterone improved sexual function in several randomized controlled trials. Women with hypoactive sexual desire disorder who were treated with testosterone reported more satisfying sexual episodes and sexual desire compared with the placebo group. Adverse ef...
Source: Acta Obstetricia et Gynecologica Scandinavica - February 11, 2020 Category: OBGYN Authors: Nora Johansen, Angelica Lind én Hirschberg, Mette Haase Moen Tags: COMMENTARY Source Type: research

Incidence and risk factors of hyperemesis gravidarum: A national register ‐based study in Finland, 2005–2017
ConclusionsOur novel study setting provided new insights about risk factors: hyperemetic pregnancies differ both from pregnancies of women who had never been diagnosed with hyperemesis and from hyperemetic women's non ‐hyperemetic pregnancies. Incidence of hyperemesis gravidarum in Finland was comparable to other countries. (Source: Acta Obstetricia et Gynecologica Scandinavica)
Source: Acta Obstetricia et Gynecologica Scandinavica - February 11, 2020 Category: OBGYN Authors: Miina Nurmi, P äivi Rautava, Mika Gissler, Tero Vahlberg, Päivi Polo‐Kantola Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Cervical dilation at the time of epidural catheter insertion is not associated with the degree of prolongation of the first or second stages of labor, or the rate of instrumental vaginal delivery
We examined whether cervical dilation at EA administration correlated with the duration of the first and/or second stage, with the rate of prolonged second stage, and with the rate of interventional delivery. The study group was stratified to 10 subgroups defined by 1‐ cm intervals of cervical dilation at EA administration. Logistic regression modeling was applied to analyze the association between EA timing and rate of instrumental delivery while controlling for possible confounders.ResultsIn primiparas, receiving EA correlated with longer medians of active first stage (+51 mins; p
Source: Acta Obstetricia et Gynecologica Scandinavica - February 11, 2020 Category: OBGYN Authors: Michal Lipschuetz, Eshel A. Nir, Sarah M. Cohen, Joshua Guedalia, Hila Hochler, Hagai Amsalem, Gilad Karavani, Drorith Hochner ‐Celnikier, Ron Unger, Simcha Yagel Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Preimplantation genetic testing practices in the Nordic countries
ConclusionsPGT is organised in rather few clinics in the Nordic countries and most of them use local laboratories for genetic analyses of the biopsies. Laboratory procedures are largely in accordance with international guidelines and the outcome after PGT in terms of clinical pregnancy per transfer is comparable to results in international reports. (Source: Acta Obstetricia et Gynecologica Scandinavica)
Source: Acta Obstetricia et Gynecologica Scandinavica - February 11, 2020 Category: OBGYN Authors: Julius Hreinsson, Erik Iwarsson, Charles Hanson, Marie Louise Gr øndahl, Kristine Løssl, Christel Hydén‐Granskog, Hans Jakob Ingerslev, The PGT study group, Morten Rønn Petersen, Peter Bredbacka, Bugge Nøhr, Linda Savolainen, Christina Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

A systematic review on concurrent aneuploidy screening and preimplantation genetic testing for hereditary disorders: what is the prevalence of aneuploidy and is there a clinical effect from aneuploidy screening?
ConclusionOn average aneuploidy is detected in 34 % of embryos when performing a single blastocyst biopsy derived from patients carrying or affected by an inherited disorder. Accordingly, when screening for aneuploidy, the risk of experiencing a cycle with no transferable embryos increases. Current available data on the clinical effect of preimplantation genetic testing for aneuploidy performed concurrently with preimplantation genetic testing for inherited disorders is sparse, rendering the clinical effect from preimplantation genetic testing for aneuploidy difficult to access. (Source: Acta Obstetricia et Gynecologica Scandinavica)
Source: Acta Obstetricia et Gynecologica Scandinavica - February 11, 2020 Category: OBGYN Authors: Christian Liebst Frisk Toft, Hans Jakob Ingerslev, Ulrik Schi øler Kesmodel, Tue Diemer, Birte Degn, Anja Ernst, Henrik Okkels, Kristín Rós Kjartansdóttir, Inge Søkilde Pedersen Tags: SYSTEMATIC REVIEW Source Type: research

Preimplantation genetic testing practices in the Nordic countries
ConclusionsPGT is organised in rather few clinics in the Nordic countries and most of them use local laboratories for genetic analyses of the biopsies. Laboratory procedures are largely in accordance with international guidelines and the outcome after PGT in terms of clinical pregnancy per transfer is comparable to results in international reports. (Source: Acta Obstetricia et Gynecologica Scandinavica)
Source: Acta Obstetricia et Gynecologica Scandinavica - February 11, 2020 Category: OBGYN Authors: Julius Hreinsson, Erik Iwarsson, Charles Hanson, Marie Louise Gr øndahl, Kristine Løssl, Christel Hydén‐Granskog, Hans Jakob Ingerslev, The PGT study group, Morten Rønn Petersen, Peter Bredbacka, Bugge Nøhr, Linda Savolainen, Christina Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

A systematic review on concurrent aneuploidy screening and preimplantation genetic testing for hereditary disorders: what is the prevalence of aneuploidy and is there a clinical effect from aneuploidy screening?
ConclusionOn average aneuploidy is detected in 34 % of embryos when performing a single blastocyst biopsy derived from patients carrying or affected by an inherited disorder. Accordingly, when screening for aneuploidy, the risk of experiencing a cycle with no transferable embryos increases. Current available data on the clinical effect of preimplantation genetic testing for aneuploidy performed concurrently with preimplantation genetic testing for inherited disorders is sparse, rendering the clinical effect from preimplantation genetic testing for aneuploidy difficult to access. (Source: Acta Obstetricia et Gynecologica Scandinavica)
Source: Acta Obstetricia et Gynecologica Scandinavica - February 11, 2020 Category: OBGYN Authors: Christian Liebst Frisk Toft, Hans Jakob Ingerslev, Ulrik Schi øler Kesmodel, Tue Diemer, Birte Degn, Anja Ernst, Henrik Okkels, Kristín Rós Kjartansdóttir, Inge Søkilde Pedersen Tags: SYSTEMATIC REVIEW Source Type: research

Cervical dilation at the time of epidural catheter insertion is not associated with the degree of prolongation of the first or second stages of labor, or the rate of instrumental vaginal delivery
We examined whether cervical dilation at EA administration correlated with the duration of the first and/or second stage, with the rate of prolonged second stage, and with the rate of interventional delivery. The study group was stratified to 10 subgroups defined by 1‐ cm intervals of cervical dilation at EA administration. Logistic regression modeling was applied to analyze the association between EA timing and rate of instrumental delivery while controlling for possible confounders.ResultsIn primiparas, receiving EA correlated with longer medians of active first stage (+51 mins; p
Source: Acta Obstetricia et Gynecologica Scandinavica - February 8, 2020 Category: OBGYN Authors: Michal Lipschuetz, Eshel A. Nir, Sarah M. Cohen, Joshua Guedalia, Hila Hochler, Hagai Amsalem, Gilad Karavani, Drorith Hochner ‐Celnikier, Ron Unger, Simcha Yagel Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Short ‐term surgical complications after radical hysterectomy—A nationwide cohort study
ConclusionsShort ‐term surgical complications developed in 35% of the women after radical hysterectomy for early‐stage cervical cancer in the Netherlands, a nation with centralized surgical care. Comorbidities predict surgical complications, and open surgery is associated with excessive perioperative blood loss. (Source: Acta Obstetricia et Gynecologica Scandinavica)
Source: Acta Obstetricia et Gynecologica Scandinavica - February 8, 2020 Category: OBGYN Authors: Hans H. B. Wenzel, Roy F. P. M. Kruitwagen, Hans W. Nijman, Ruud L. M. Bekkers, Toon Gorp, Cornelis D. Kroon, Luc R. C. W. Lonkhuijzen, Leon F. A. G. Massuger, Ramon G. V. Smolders, Nienke E. Trommel, Refika Yigit, Ronald P. Zweemer, Maaike A. Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

The role of testosterone in menopausal hormone treatment. What is the evidence?
AbstractAbout 40% of postmenopausal women have decreased sexual desire causing distress. Estrogen therapy attenuates vaginal complaints, but has no effect on sexual desire. Although sexual function has been linked to testosterone, there is no clear relation between sexual desire and circulating levels of testosterone. Nevertheless, treatment with transdermal (patch) testosterone improved sexual function in several randomized controlled trials. Women with hypoactive sexual desire disorder who were treated with testosterone reported more satisfying sexual episodes and sexual desire compared with the placebo group. Adverse ef...
Source: Acta Obstetricia et Gynecologica Scandinavica - February 8, 2020 Category: OBGYN Authors: Nora Johansen, Angelica Lind én Hirschberg, Mette Haase Moen Tags: COMMENTARY Source Type: research

Incidence and risk factors of hyperemesis gravidarum: A national register ‐based study in Finland, 2005–2017
ConclusionsOur novel study setting provided new insights about risk factors: hyperemetic pregnancies differ both from pregnancies of women who had never been diagnosed with hyperemesis and from hyperemetic women's non ‐hyperemetic pregnancies. Incidence of hyperemesis gravidarum in Finland was comparable to other countries. (Source: Acta Obstetricia et Gynecologica Scandinavica)
Source: Acta Obstetricia et Gynecologica Scandinavica - February 8, 2020 Category: OBGYN Authors: Miina Nurmi, P äivi Rautava, Mika Gissler, Tero Vahlberg, Päivi Polo‐Kantola Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

"It's probably nothing, but …" Couples' experiences of pregnancy following an uncertain prenatal genetic result
ConclusionsThe results indicate that health professionals should be mindful of terminology, remember to point out what has been ruled out by the CNV result, and discuss potential coping strategies with the couple. Furthermore, these couples may have a higher need for ultrasound during pregnancy to help reduce worry. More research is needed on the families' long ‐term coping. (Source: Acta Obstetricia et Gynecologica Scandinavica)
Source: Acta Obstetricia et Gynecologica Scandinavica - February 6, 2020 Category: OBGYN Authors: Stina Lou, Kirsten Lomborg, Celine Lewis, Sam Riedijk, Olav Bj ørn Petersen, Ida Vogel Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Seasonal variation in the hypertensive disorders of pregnancy in Denmark
ConclusionsWe found a seasonal variation in the risk of the hypertensive disorders of pregnancy in a large cohort of Danish nulliparous women. The highest risk was seen in women with the estimated date of conception in June and August, that is, during summer. Seasonal variation in vitamin D status may explain this association. (Source: Acta Obstetricia et Gynecologica Scandinavica)
Source: Acta Obstetricia et Gynecologica Scandinavica - February 5, 2020 Category: OBGYN Authors: Christine Rohr Thomsen, Tine Brink Henriksen, Niels Uldbjerg, Ioanna Milidou Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Diagnostic accuracy of repeat placental growth factor measurements in women with suspected preeclampsia: a case series study
AbstractIntroductionPreeclampsia affects about 3% of singleton pregnancies, and is characterised by placental dysfunction. It is associated with significant maternal and perinatal morbidity and mortality. The diagnosis of preeclampsia remains a challenge, and the clinical course can develop over weeks before a diagnosis is confirmed. National guidelines have approved placental growth factor (PlGF) testing to rule out suspected preeclampsia, but the utility of repeated PlGF measurement is unknown. The aim of this case series analysis was to evaluate the test performance of repeated PlGF sampling in women presenting with sus...
Source: Acta Obstetricia et Gynecologica Scandinavica - February 5, 2020 Category: OBGYN Authors: Kate E Duhig, Louise M Webster, Andrew Sharp, Carolyn Gill, Paul T Seed, Andrew H Shennan, Jenny E Myers, Lucy C Chappell Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Levonorgestrel ‐releasing intrauterine system and breast cancer risk: A systematic review and meta‐analysis
AbstractIntroductionEpidemiological studies have shown that some hormonal contraceptive methods are associated with increased breast cancer risk, especially if used over long periods. Our objective was to conduct a systematic review and meta ‐analysis of the literature on the risk of breast cancer development in women using the 52‐mg levonorgestrel‐releasing intrauterine system (LNG‐IUS).Material and methodsWe performed a thorough review of peer ‐reviewed publications from January 10, 1999, through July 31, 2019, using combinations of search terms for breast cancer risk and LNG‐IUS in the Medline, EMBASE, LILAC...
Source: Acta Obstetricia et Gynecologica Scandinavica - February 2, 2020 Category: OBGYN Authors: Livia Conz, Bruna Salani Mota, Luis Bahamondes, Ma íra Teixeira Dória, Sophie Françoise Mauricette Derchain, Rachel Rieira, Luis O. Sarian Tags: SYSTEMATIC REVIEW Source Type: research

Intra ‐placental arterial Doppler: A marker of fetoplacental vascularity in late‐onset placental disease?
AbstractIntroductionLate ‐gestation adverse pregnancy outcome is associated with reduced placental villous vascularity but rarely with a frankly abnormal umbilical artery Doppler waveform. The clinical utility of umbilical artery Doppler velocimetry in late gestation is limited by poor understanding of what aspect(s) of p lacental structure and function the impedance reflects. We hypothesized that placental arterial circulation impedance reflects placental vascularity and arterial function.Material and methodsThis was a secondary analysis of data from the FEMINA2 study, a study of pregnancy outcome after reduced fetal mo...
Source: Acta Obstetricia et Gynecologica Scandinavica - February 2, 2020 Category: OBGYN Authors: Lucy E. Higgins, Alexander E. P. Heazell, Louise E. Simcox, Edward D. Johnstone Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Low ‐dose‐aspirin usage among women with an increased preeclampsia risk: A prospective cohort study
ConclusionsRisk ‐based counseling was associated with a higher prevalence of LDA usage, but general usage rates were low. Future research regarding potential factors improving the usage of LDA during pregnancy is necessary. (Source: Acta Obstetricia et Gynecologica Scandinavica)
Source: Acta Obstetricia et Gynecologica Scandinavica - February 2, 2020 Category: OBGYN Authors: Pim Montfort, Hubertina C. J. Scheepers, Ivo M. A. Dooren, Linda J. E. Meertens, Maartje Zelis, Iris M. Zwaan, Marc E. A. Spaanderman, Luc J. M. Smits Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Levonorgestrel ‐releasing intrauterine system and breast cancer risk: A systematic review and meta‐analysis
AbstractIntroductionEpidemiological studies have shown that some hormonal contraceptive methods are associated with increased breast cancer risk, especially if used over long periods. Our objective was to conduct a systematic review and meta ‐analysis of the literature on the risk of breast cancer development in women using the 52‐mg levonorgestrel‐releasing intrauterine system (LNG‐IUS).Material and methodsWe performed a thorough review of peer ‐reviewed publications from January 10, 1999, through July 31, 2019, using combinations of search terms for breast cancer risk and LNG‐IUS in the Medline, EMBASE, LILAC...
Source: Acta Obstetricia et Gynecologica Scandinavica - January 28, 2020 Category: OBGYN Authors: Livia Conz, Bruna Salani Mota, Luis Bahamondes, Ma íra Teixeira Dória, Sophie Françoise Mauricette Derchain, Rachel Rieira, Luis O. Sarian Tags: SYSTEMATIC REVIEW Source Type: research

Intra ‐placental arterial Doppler: A marker of fetoplacental vascularity in late‐onset placental disease?
AbstractIntroductionLate ‐gestation adverse pregnancy outcome is associated with reduced placental villous vascularity but rarely with a frankly abnormal umbilical artery Doppler waveform. The clinical utility of umbilical artery Doppler velocimetry in late gestation is limited by poor understanding of what aspect(s) of p lacental structure and function the impedance reflects. We hypothesized that placental arterial circulation impedance reflects placental vascularity and arterial function.Material and methodsThis was a secondary analysis of data from the FEMINA2 study, a study of pregnancy outcome after reduced fetal mo...
Source: Acta Obstetricia et Gynecologica Scandinavica - January 28, 2020 Category: OBGYN Authors: Lucy E. Higgins, Alexander E. P. Heazell, Louise E. Simcox, Edward D. Johnstone Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Cesarean delivery: trend in indications over three decades within a major city hospital network
ConclusionsThe increased rate of cesarean delivery is mainly attributable to more procedures performed for slow progress in labor, breech presentation or repeat cesarean section. (Source: Acta Obstetricia et Gynecologica Scandinavica)
Source: Acta Obstetricia et Gynecologica Scandinavica - January 24, 2020 Category: OBGYN Authors: Rhett Morton, Alice Elizabeth Burton, Praneel Kumar, Jon Anthony Hyett, Hala Phipps, Kevin McGeechan, Bradley Stephen de Vries Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Reduced fetal movements at term in singleton low risk pregnancies ‐ is there an association with placental histopathological findings?
AbstractIntroductionMaternal perception of fetal movements has long been considered an indicator of fetal well ‐being. A sudden decrease in the number of fetal movements is suggestive of fetal compromise. We aimed to determine whether the maternal perception of reduced fetal movements (RFM) is associated with placental pathological lesions in a low‐risk term population.Material and methodsOur study was a case ‐control study, that was performed in a single university‐center. Placental histopathology, maternal demographics, labor characteristics, and neonatal outcomes of term, singleton pregnancies with maternal perc...
Source: Acta Obstetricia et Gynecologica Scandinavica - January 20, 2020 Category: OBGYN Authors: Michal Levy, Michal Kovo, Yakira Izaik, Isca Luwisch Cohen, Letizia Schreiber, Hadas Ganer Herman, Giulia Barda, Jacob Bar, Eran Weiner Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Characteristics and trends of sexual assaults in Israel – a large cohort study of 3941 victims
AbstractIntroductionIn order to improve care for victims of sexual assault, specialized assault centers have been developed globally, providing medical, psychological and legal care in one place. Our assault center serves a large population in the center of Israel. In 2010, we initiated a program aimed to prevent assaults among minors and to encourage early referral of victims to the center. The goal of the current study was to assess the impact of this program by comparing the characteristics of sexual assaults before and after its initiation.Material and methodsWe conducted a historic cohort study of all victims of sexua...
Source: Acta Obstetricia et Gynecologica Scandinavica - January 20, 2020 Category: OBGYN Authors: Yossi Mizrachi, Jacob Bar, Giulia Barda Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Reduced fetal movements at term in singleton low risk pregnancies ‐ is there an association with placental histopathological findings?
AbstractIntroductionMaternal perception of fetal movements has long been considered an indicator of fetal well ‐being. A sudden decrease in the number of fetal movements is suggestive of fetal compromise. We aimed to determine whether the maternal perception of reduced fetal movements (RFM) is associated with placental pathological lesions in a low‐risk term population.Material and methodsOur study was a case ‐control study, that was performed in a single university‐center. Placental histopathology, maternal demographics, labor characteristics, and neonatal outcomes of term, singleton pregnancies with maternal perc...
Source: Acta Obstetricia et Gynecologica Scandinavica - January 20, 2020 Category: OBGYN Authors: Michal Levy, Michal Kovo, Yakira Izaik, Isca Luwisch Cohen, Letizia Schreiber, Hadas Ganer Herman, Giulia Barda, Jacob Bar, Eran Weiner Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Characteristics and trends of sexual assaults in Israel – a large cohort study of 3941 victims
AbstractIntroductionIn order to improve care for victims of sexual assault, specialized assault centers have been developed globally, providing medical, psychological and legal care in one place. Our assault center serves a large population in the center of Israel. In 2010, we initiated a program aimed to prevent assaults among minors and to encourage early referral of victims to the center. The goal of the current study was to assess the impact of this program by comparing the characteristics of sexual assaults before and after its initiation.Material and methodsWe conducted a historic cohort study of all victims of sexua...
Source: Acta Obstetricia et Gynecologica Scandinavica - January 20, 2020 Category: OBGYN Authors: Yossi Mizrachi, Jacob Bar, Giulia Barda Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

The predictive capacity of uterine artery Doppler for preterm birth —A cohort study
ConclusionsMid ‐trimester uterine artery resistance measured at 18‐22 weeks of gestation is a weak predictor of spontaneous preterm birth. (Source: Acta Obstetricia et Gynecologica Scandinavica)
Source: Acta Obstetricia et Gynecologica Scandinavica - January 19, 2020 Category: OBGYN Authors: Maud D. Zijl, Bouchra Koullali, Ben W. J. Mol, Rosalinde J. Snijders, Brenda M. Kazemier, Eva Pajkrt Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Low ‐dose‐aspirin usage among women with an increased pre‐eclampsia risk: a prospective cohort study
ConclusionsRisk ‐based counseling was associated with a higher prevalence of LDA usage, but general usage rates were low. Future research regarding potential factors improving the usage of LDA during pregnancy is necessary. (Source: Acta Obstetricia et Gynecologica Scandinavica)
Source: Acta Obstetricia et Gynecologica Scandinavica - January 18, 2020 Category: OBGYN Authors: Pim van Montfort, Hubertina C.J. Scheepers, Ivo M.A. van Dooren, Linda J.E. Meertens, Maartje Zelis, Iris M. Zwaan, Marc E.A. Spaanderman, Luc J.M. Smits Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

CA ‐125 reduction during neoadjuvant chemotherapy is associated with success of cytoreductive surgery and outcome of patients with advanced high‐grade ovarian cancer
The objective was to assess whether an early response to neoadjuvant chemotherapy in patients with advanced ovarian cancer may predict short ‐ and long‐term clinical outcome.Material and methodsThis is a retrospective study of all patients with stage III ‐IV tubo‐ovarian cancer treated with neoadjuvant chemotherapy at a single center in Montreal between 2003 and 2014. Logistic regression models were used to evaluate the association between cancer antigen 125 (CA‐125) levels during neoadjuvant chemotherapy and debulking success. Cox proportiona l hazard models were used to estimate hazard ratios and their respecti...
Source: Acta Obstetricia et Gynecologica Scandinavica - January 18, 2020 Category: OBGYN Authors: Roy Kessous, Michel D. Wissing, Sabrina Piedimonte, Jeremie Abitbol, Liron Kogan, Ido Laskov, Amber Yasmeen, Shannon Salvador, Susie Lau, Walter H. Gotlieb Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

External validation and clinical utility of prognostic prediction models for gestational diabetes mellitus: a prospective cohort study
ConclusionsThe best performing prediction models showed acceptable performance measures and may enable more personalized based antenatal care for women at risk of developing GDM compared to current applied strategies. (Source: Acta Obstetricia et Gynecologica Scandinavica)
Source: Acta Obstetricia et Gynecologica Scandinavica - January 18, 2020 Category: OBGYN Authors: Linda J.E. Meertens, Hubertina C.J. Scheepers, Sander M.J. van Kuijk, Nel Roeleveld, Robert Aardenburg, Ivo M.A. van Dooren, Josje Langenveld, Iris M. Zwaan, Marc E.A. Spaanderman, Marleen M.H.J. van Gelder, Luc JM Smits Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Short ‐term surgical complications after radical hysterectomy ‐ a nationwide cohort study
ConclusionsShort ‐term surgical complications develop in 35% of the women after radical hysterectomy for early‐stage cervical cancer in the Netherlands, a nation with centralised surgical care. Comorbidities predict surgical complications and open surgery is associated with excessive perioperative blood loss. (Source: Acta Obstetricia et Gynecologica Scandinavica)
Source: Acta Obstetricia et Gynecologica Scandinavica - January 18, 2020 Category: OBGYN Authors: Hans H.H.B. Wenzel, Roy R.F.P.M. Kruitwagen, Hans H.W. Nijman, Ruud R.L.M. Bekkers, Toon Van Gorp, Cornelis C.D. de Kroon, Luc L.R.C.W. van Lonkhuijzen, Leon L.F.A.G. Massuger, Ramon R.G.V. Smolders, Nienke N.E. van Trommel, Refika R. Yigit, Ro Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

"It's probably nothing, but …" Couples' experiences of pregnancy following a uncertain prenatal genetic result
ConclusionsThe results indicate that health professionals should be mindful of terminology, remember to point out what has been ruled out by the CNV result, and discuss potential coping strategies with the couple. Furthermore, these couples may have a higher need for ultrasound during pregnancy to help reduce worry. More research is needed on the families' long ‐term coping. (Source: Acta Obstetricia et Gynecologica Scandinavica)
Source: Acta Obstetricia et Gynecologica Scandinavica - January 18, 2020 Category: OBGYN Authors: Stina Lou, Kirsten Lomborg, Celine Lewis, Sam Riedijk, Olav Bj ørn Petersen, Ida Vogel Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Low ‐dose‐aspirin usage among women with an increased pre‐eclampsia risk: a prospective cohort study
ConclusionsRisk ‐based counseling was associated with a higher prevalence of LDA usage, but general usage rates were low. Future research regarding potential factors improving the usage of LDA during pregnancy is necessary. (Source: Acta Obstetricia et Gynecologica Scandinavica)
Source: Acta Obstetricia et Gynecologica Scandinavica - January 18, 2020 Category: OBGYN Authors: Pim van Montfort, Hubertina C.J. Scheepers, Ivo M.A. van Dooren, Linda J.E. Meertens, Maartje Zelis, Iris M. Zwaan, Marc E.A. Spaanderman, Luc J.M. Smits Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

CA ‐125 reduction during neoadjuvant chemotherapy is associated with success of cytoreductive surgery and outcome of patients with advanced high‐grade ovarian cancer
The objective was to assess whether an early response to neoadjuvant chemotherapy in patients with advanced ovarian cancer may predict short ‐ and long‐term clinical outcome.Material and methodsThis is a retrospective study of all patients with stage III ‐IV tubo‐ovarian cancer treated with neoadjuvant chemotherapy at a single center in Montreal between 2003 and 2014. Logistic regression models were used to evaluate the association between cancer antigen 125 (CA‐125) levels during neoadjuvant chemotherapy and debulking success. Cox proportiona l hazard models were used to estimate hazard ratios and their respecti...
Source: Acta Obstetricia et Gynecologica Scandinavica - January 18, 2020 Category: OBGYN Authors: Roy Kessous, Michel D. Wissing, Sabrina Piedimonte, Jeremie Abitbol, Liron Kogan, Ido Laskov, Amber Yasmeen, Shannon Salvador, Susie Lau, Walter H. Gotlieb Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

External validation and clinical utility of prognostic prediction models for gestational diabetes mellitus: a prospective cohort study
ConclusionsThe best performing prediction models showed acceptable performance measures and may enable more personalized based antenatal care for women at risk of developing GDM compared to current applied strategies. (Source: Acta Obstetricia et Gynecologica Scandinavica)
Source: Acta Obstetricia et Gynecologica Scandinavica - January 18, 2020 Category: OBGYN Authors: Linda J.E. Meertens, Hubertina C.J. Scheepers, Sander M.J. van Kuijk, Nel Roeleveld, Robert Aardenburg, Ivo M.A. van Dooren, Josje Langenveld, Iris M. Zwaan, Marc E.A. Spaanderman, Marleen M.H.J. van Gelder, Luc JM Smits Tags: ORIGINAL RESEARCH ARTICLE Source Type: research