Chemo-Radiation After Upfront Rectal Resections —a Clinical Dilemma
AbstractTo compare the impact of adjuvant chemo-radiotherapy (ACRT) versus adjuvant chemotherapy (ACT) alone on recurrence and survival in patients with stage II and III rectal adenocarcinoma undergoing upfront curative resection. Prospective observational review of colorectal database at Tata Memorial Hospital from July 2010 to March 2015 identified 84 patients who underwent upfront curative resection for stage II or III rectal cancer. None of the patient received preoperative chemo-radiation. Of these, adjuvant chemo-radiotherapy was administered to 29 patients (ACRT group) and 55 patients received CAPEOX/FOLFOX-based ad...
Source: Indian Journal of Surgical Oncology - August 18, 2018 Category: Cancer & Oncology Source Type: research

From the Desk of the Editor
(Source: Indian Journal of Surgical Oncology)
Source: Indian Journal of Surgical Oncology - August 15, 2018 Category: Cancer & Oncology Source Type: research

Current Status of Lymphadenectomy During Radical Nephroureterectomy for Upper Tract Urothelial Cancer —Yes, No or Maybe?
This article elucidates the current knowledge on outcomes, benefits and complications of template-based lymphadenectomy during radical nephroureterectomy for UTUC. We also explore the current evidence-based guidelines on this controversial topic. (Source: Indian Journal of Surgical Oncology)
Source: Indian Journal of Surgical Oncology - August 13, 2018 Category: Cancer & Oncology Source Type: research

Encapsulated Follicular Variant of Papillary Thyroid Carcinoma Arising in a Follicular Adenoma: a Diagnostic Dilemma
AbstractPapillary thyroid carcinoma (PTC) arising within follicular adenoma is a rare histological subset of papillary carcinoma. A 24-year-old female (euthyroid and asymptomatic) presented with a solitary mass in the right lobe of thyroid for 2  years. Fine-needle aspiration cytology (FNAC) suggested features of hyperplasia of thyroid. Hemithyroidectomy was performed. Histopathological examination revealed two distinct areas and was reported as encapsulated variant of papillary carcinoma along with follicular adenoma. Papillary carcinoma was confirmed by positive immunohistochemistry for HBME-1. CT head and neck regi...
Source: Indian Journal of Surgical Oncology - August 13, 2018 Category: Cancer & Oncology Source Type: research

Resection of Isolated Port Site Metastasis in Gall Bladder Cancers —Careful Selection and Perioperative Systemic Therapy May Improve Outcomes
AbstractExcision of port site (PSE) for patients having undergone laparoscopic cholecystectomy (LC) is not a standard recommendation. We retrospectively evaluated a cohort of patients with isolated PSM without any prior cancer-directed therapy who were assessed for resection between March 2012 and July 2016 at Tata Memorial Hospital, Mumbai. Eleven of a total 13 patients underwent wide excision for PSM in the given time period. Upfront resection was undertaken in six patients while seven patients received neoadjuvant chemotherapy (NACT) and two received neoadjuvant chemo radiotherapy (NACTRT) prior to attempted resection. ...
Source: Indian Journal of Surgical Oncology - August 10, 2018 Category: Cancer & Oncology Source Type: research

Completion Total Laryngectomy Ten Years After Near Total Laryngectomy for Radiorecurrent Cancer of the Glottis
AbstractNear total laryngectomy (NTL) is a safe alternative to total laryngectomy in salvaging lateralized radiation failures. A 65-year-old gentleman with radiorecurrent T1 vocal cord cancer was salvaged successfully by NTL. Ten years later, he presented with a strained shunt speech which was treated judiciously, with the aid of a positron emission tomography (PET) scan, by a (completion) total laryngectomy (TL), bilateral selective neck dissection, and pharyngeal resurfacing with pectoralis major myocutaneous (PMMC) flap. The patient is on close follow-up after the second salvage procedure, for 20  months without an...
Source: Indian Journal of Surgical Oncology - August 9, 2018 Category: Cancer & Oncology Source Type: research

Primary Appendicular Malignancy Presenting as Abdominal Wall Abscess with Secondary Tuberculosis Infection: an Interesting Case Report
AbstractCancers of the appendix are rare. Most of them are found accidentally on appendectomies performed for appendicitis. When reviewed, majority of the tumors were carcinoid, adenoma, and lymphoma. Adenocarcinomas of the appendix are only 0.08% of all cancers, and the treatment remains controversial. It can present as appendicitis or lump or abscess. Gastrointestinal tuberculosis most commonly involves the ileocecal region. Disruption of the integrity of mucosal barriers and impairment in cell-mediated immunity associated with cancerous growth are known to predispose to bacterial infection. The role of antituberculosis ...
Source: Indian Journal of Surgical Oncology - August 7, 2018 Category: Cancer & Oncology Source Type: research

Transanal Total Mesorectal Excision for Treatment of Carcinoma in the Middle or Lower Third Rectum: the Technical Feasibility of the Procedure, Pathological Results, and Clinical Outcome
This study included 25 consecutive patients who underwent TaTME for the mid and low cancer rectum. The primary outcome measures included frequency of postoperative (PO) bleeding, leakage, ileus, days to regain bowel function, days for Foley ’s removal, and erectile function. The secondary outcome measures included operation time, status of resection margins, number, the quality of TME, and duration PO hospital stay. No recorded intraoperative complications. The mean hospital stay was 6.9 ± 2.6 days. The mean duration need for u rinary catheter removal and flatus passage were 2.4 &plus...
Source: Indian Journal of Surgical Oncology - August 4, 2018 Category: Cancer & Oncology Source Type: research

Carcinosarcoma of Tongue with Predominant Osteosarcomatous Component
We report a case of carcinosarcoma of tongue in a 51-year-old male with predominant osteosarcomatous and squamous cell carcinoma components. There was no evidence of regional or systemic metastatic disease. This case represents the first reported example of this unusual neoplasm with a predominant osteosarcomatous component, arising in the tongue. (Source: Indian Journal of Surgical Oncology)
Source: Indian Journal of Surgical Oncology - August 3, 2018 Category: Cancer & Oncology Source Type: research

Clinical Utility of Staging Laparoscopy for Advanced Obstructing Rectal Adenocarcinoma: Emerging Tool
This study aims to evaluate the clinical value of SL in treatment decision-making for advanced rectal cancer (RC) with near or complete obstructing tumors. Observational review of colorectal database at Tata Memorial Hospital from January 2013 to December 2016 identified 562 patients diagnosed and treated for advanced RC. Of the 562 cases, 48.7% (274) were clinically and radiologically diagnosed of near or complete obstructing advanced RC. Medical records of 34% (94/274) who underwent SL with diversion stoma (DS) were analyzed. In the absence of ascites, extensive peritoneal deposits, and unresectable liver metastases on S...
Source: Indian Journal of Surgical Oncology - August 2, 2018 Category: Cancer & Oncology Source Type: research

Safety and Efficacy of Low-Dose Single-Agent Capecitabine in Inoperable Gallbladder Cancer with Jaundice Post-Single-System Single-Catheter External Biliary Drainage: a Pilot Study from a Highly Endemic Area
AbstractGallbladder cancer (CaGB) in the subcontinent belongs to low socioeconomic status, and at the time of diagnosis, a large number is unresectable or inoperable so the palliative treatment remains the only option. In the present study, attempt was made to see the effect and safety profile of single-agent oral capecitabine in inoperable CaGB in presence of low levels of jaundice post-single-catheter transhepatic external biliary drainage. InN = 35 of inoperable jaundiced CaGB, post-biliary drainage capecitabine in low dose was started when their total bilirubin levels fell to 10 mg% or below. Post-ex...
Source: Indian Journal of Surgical Oncology - July 31, 2018 Category: Cancer & Oncology Source Type: research

P-Glycoprotein Expression in Indian Breast Cancer Patients with Reference to Molecular Subtypes and Response to Anthracycline-Based Chemotherapy —a Prospective Clinical Study from a Developing Country
AbstractChemo-resistance is an important factor determining the response of tumor to neoadjuvant chemotherapy (NACT). Our study was aimed to determine the role of P-glycoprotein (P-glyp) expression as a predictor of response to NACT in locally advanced breast cancer (LABC) patients with special reference to molecular subtypes. Sixty cases of locally advanced breast cancer (LABC) were subjected to trucut biopsy and the tissue samples were evaluated immunohistochemically for P-glyp, ER, PR, and Her 2 neu status. Pre- and post-NACT P-glyp expression was correlated with clinical response (using WHO criteria after three cycles ...
Source: Indian Journal of Surgical Oncology - July 31, 2018 Category: Cancer & Oncology Source Type: research

Primary Osteosarcoma of the Breast
AbstractExtraskeletal osteosarcomas are extremely rare and account for
Source: Indian Journal of Surgical Oncology - July 30, 2018 Category: Cancer & Oncology Source Type: research

Catheter Fracture of Subclavian Venous Chemoport Device at Costoclavicular Junction: Pinch-off Syndrome
We present a case of a 35-year-old lady, a case of carcinoma breast, who had spontaneous fracture of chemoport access device in subclavian vein at the level of clavicle after four successful cycles of chemotherapy. The fracture was suspected on chest x-ray and was subsequently confirmed on contrast linogram. The patient was successfully managed with endovascular interventional technique without suffering any ill effects. It is a rare presentation of pinch-off syndrome. (Source: Indian Journal of Surgical Oncology)
Source: Indian Journal of Surgical Oncology - July 30, 2018 Category: Cancer & Oncology Source Type: research

Utility of Preoperative Staging of Ipsilateral Axilla with Ultrasound and Guided Needle Aspiration in Early-Stage Breast Cancer —Current Indian Scenario
In this study, we aim to compare physical examination and ultrasound of axilla and FNAC and assess their accuracy in preoperative staging of axilla. This was a prospective observational study. Patients with biopsy-proven in vasive early-stage breast carcinoma, consenting to be part of the study, underwent ultrasound (US) of ipsilateral axilla with guided FNAC, when indicated and underwent surgery which included complete axillary dissection. Postoperative histopathology was compared to preoperative US and guided cytolog y (if done), to correlate the latter’s efficacy in detecting positive axillary nodes. Clinically, 9...
Source: Indian Journal of Surgical Oncology - July 26, 2018 Category: Cancer & Oncology Source Type: research

Rising Incidence of Breast Cancer in the Young Fertile Indian Population —a Reality Check
AbstractBreast cancer in India appears to be diagnosed more in the young women, but whether this is an actual higher incidence, and hence a matter of concern, needs more clarity, and the extent to which correctable measures can be taken to reduce or overcome this additional disease burden, if any, has to be better understood. The article analyzes these and more in a systematic manner and highlights the important issues in the very young women which makes the clinical management of breast cancer more complex. (Source: Indian Journal of Surgical Oncology)
Source: Indian Journal of Surgical Oncology - July 23, 2018 Category: Cancer & Oncology Source Type: research

Bladder Invasion in Patients with Advanced Colorectal Carcinoma
In this study, we report our experience in the management of operable locally advanced colorectal carcinomas involving the urinary bladder. We retrospectively reviewed the hospital records of all patients with advanced colorectal cancer invading the urinary bladder. The age, gender, clinical presentation, physical examination findings, and imaging records were noted. Colonoscopy reports and images were noted and biopsy findings recorded. Similarly, cystoscopy findings and biopsy reports were noted and analyzed. Eight (88%) patients had a primary sigmoid tumor and one (11%) had primary rectal tumor. The clinical staging of ...
Source: Indian Journal of Surgical Oncology - July 23, 2018 Category: Cancer & Oncology Source Type: research

Anorectal Malignant Melanoma —Defining the Optimal Surgical Treatment and Prognostic Factors
AbstractPatients with anorectal malignant melanoma (ARMM) have a poor prognosis. Optimal surgical treatment is not defined. The aim of the study was to define the surgical treatment for ARMM, to compare the overall survival (OS) of abdomino-perineal resection (APR) and wide local excision (WLE) and to study various prognostic factors. Thirty patients of ARMM were managed, 20 with locoregional disease, 10 metastatic. Of the 20 patients with locoregional disease, 15 underwent APR and 5 WLE. The 1-, 2-, 3-, and 4-year overall survival rates (by Kaplan –Meier survival analysis) in the APR group were 67, 40, 40, and 32%, ...
Source: Indian Journal of Surgical Oncology - July 23, 2018 Category: Cancer & Oncology Source Type: research

Granular Cell Tumour in Stomach: a Case Report
AbstractGranular cell tumours are uncommon, usually benign soft tissue tumours. They are thought to be neural, arising from Schwann cells and can occur at various sites. Their occurrence in gastrointestinal tract is rare, the commonest site being oesophagus followed by large intestine. Gastric localization is unusual. A young female presented with abdominal discomfort since 3  months. Endoscopy showed a nodule in the body of stomach. Biopsy revealed features of granular cell tumour on microscopy, which was confirmed by immunohistochemical positivity for S100 and CD68. Wide excision of the tumour was performed. At the ...
Source: Indian Journal of Surgical Oncology - July 21, 2018 Category: Cancer & Oncology Source Type: research

Outcome of Bowel Resection in Women with Advanced Ovarian Carcinoma
AbstractTo evaluate the mortality and morbidity related to bowel resection in women with advanced ovarian carcinoma. Retrospective case series of 47 women with stage III and IV carcinoma ovary who underwent bowel resection, over the period of 5  years from Jan 2011 to Dec 2015. The risk factors for perioperative morbidity and death were determined by regression analysis. The disease free and overall survival were determined by Kaplan-Meier plots. In this cohort, 64% (30/47) had primary debulking, 21% (10/47) had interval debulking, and 15 % (7/47) had secondary debulking. The mean period of follow-up was 23 month...
Source: Indian Journal of Surgical Oncology - July 20, 2018 Category: Cancer & Oncology Source Type: research

Margin Status and Duration of Surgery in Resection of Tongue Carcinoma with Ultrasound Coagulation Device: a Comparative Study
This study was conducted to compare histological margins and duration of surgery between ultrasonic coagulation device and electrodiathermy in the resection of oral tongue tumours. A retrospective analysis was performed comprising patients undergoing wide excision for squamous cell carcinoma of the lateral tongue, with either ultrasonic coagulation device or conventional electrodiathermy at Our Institute in Mumbai, India, from October 2015 to December 2016. Single factor ANOVA with the level of significance set at 95% and alpha value of 0.05. Patients who underwent excision with ultrasonic coagulation devicebetter histolog...
Source: Indian Journal of Surgical Oncology - July 20, 2018 Category: Cancer & Oncology Source Type: research

Nephron Sparing Surgery for Synchronous Bilateral Wilms —Operative Steps
We report the feasibility and outcome of nephron sparing surgery in a child with bilateral Wilms tumor who was treated at our institution. (Source: Indian Journal of Surgical Oncology)
Source: Indian Journal of Surgical Oncology - July 20, 2018 Category: Cancer & Oncology Source Type: research

Occult Gallbladder Carcinoma Presenting as a Primary Ovarian Tumour: a Case Report and Review of Literature
We report a case of a metastatic gallbladder carcinoma which mimicked a primary ovarian tumour in a 31-year-old woman who presented with menstrual symptoms and an ovarian mass without obvious signs and symptoms related to gallbladder carcinoma. Postoperatively histopathological examination diagnosed primary ovarian germ cell tumour for further chemotherapy. However, postoperative re-evaluation with radiology suggested the possibility of a primary gallbladder carcinoma. Exact diagnosis could only be made after repeat histopathological evaluation of the ovarian mass. (Source: Indian Journal of Surgical Oncology)
Source: Indian Journal of Surgical Oncology - July 20, 2018 Category: Cancer & Oncology Source Type: research

Giant Calcified Retroperitoneal Teratoma
AbstractRetroperitoneal teratoma involving adrenal gland is a rare entity in adults comprising only 4% of all primary teratomas. These tumors are mainly seen in infants and children. Diagnosis is made by X-ray and CT abdomen showing the presence of large tumor with cystic and calcified walls. Here, we present an interesting image of a 16-year-old girl who presented with large (12  × 10 cm) calcified cyst occupying left side of abdomen which was treated successfully by surgical excision. (Source: Indian Journal of Surgical Oncology)
Source: Indian Journal of Surgical Oncology - July 20, 2018 Category: Cancer & Oncology Source Type: research

Pelvic Exenteration Put into Therapeutical and Palliative Perspective: It Is Worth to Try
The objective of our study was to review our experience of PE in terms of surgical characteristics, complications, and overall survival. All patients who had PE surgery between January 1999 and December 2015 were identified. Patients with verified distant metastatic disease were excluded. Patients with advanced pelvic tumors experiencing incapacitating postradiation severe damages were included. The following parameters were recorded: age, sex, indication for surgery, tumor histology, type of exenteration, urinary tract and colon reconstruction methods, operative time, blood transfusion, intensive care unit admissions, len...
Source: Indian Journal of Surgical Oncology - July 20, 2018 Category: Cancer & Oncology Source Type: research

Resection of the Inferior Vena Cava for Retroperitoneal Sarcoma: Six Cases and a Review of Literature
We present a series of six cases of resection of the IVC for retroperitoneal sarcomas, four of which were primary caval tumors. We outline the technical difficulties faced in these complex procedures and discuss the oncological outcomes of these rare tumors. We performed a retrospective review of six patients operated for retroperitoneal masses involving the inferior vena cava between April 2015 and July 2016 at our tertiary care institute. Six patients underwent resection of the IVC, three of which required a multivisceral resection. An artificial prosthesis was used to reconstruct the IVC in three patients, whereas two p...
Source: Indian Journal of Surgical Oncology - July 19, 2018 Category: Cancer & Oncology Source Type: research

Prospective Evaluation of Surgical Outcome After Transoral CO 2 Laser Resection of Potentially Malignant and Early Oral Malignancy
AbstractA prospective observational study was done at the Regional Cancer Centre, Thiruvananthapuram, a tertiary referral center for cancer care in India with an aim to assess the surgical outcomes of CO2 laser resection of oral lesions in terms of operative time, blood loss, hospital stay, postoperative pain, time to re-epithelization, pathological margins achieved and the postoperative scar. The excision was performed in 30 patients with a diagnosis of either potentially malignant lesions (leucoplakia, erythroplakia) or early cancers, i.e., carcinoma in situ or T1/T2 squamous cell carcinoma of the anterior oral cavity (t...
Source: Indian Journal of Surgical Oncology - June 30, 2018 Category: Cancer & Oncology Source Type: research

Acute Trauma Precipitating the Onset of Chest Wall Myxofibrosarcoma
AbstractA previously healthy, 47-year-old male presented to his primary care physician with the complaint of a nontender, palpable breast mass discovered coincidentally 1  month after being scratched in the same location by his pet cat. Family history revealed his father was diagnosed with a soft tissue sarcoma of the thigh, 6 months following a traumatic injury in the same location. Cat scratch disease was considered; however,Bartonella Henselae antibody testing was negative. Imaging studies revealed a subpectoral mass without rib involvement. Subsequent core biopsy revealed malignant fibrous histiocytoma, myxoi...
Source: Indian Journal of Surgical Oncology - June 20, 2018 Category: Cancer & Oncology Source Type: research

Asymptomatic Auto Amputation of Normal Ovary
We report an interesting case of this rare pathology. A 50-year-old female with postmenopausal bleeding prepared for hystere ctomy is presented here. Intraperitoneal free-floating auto-amputated right ovary was encountered. During surgery, we can suspect it from free-floating mass intraperitoneal with failure to detect one of the ovaries attached to the uterus and the related infundibulopelvic ligament. (Source: Indian Journal of Surgical Oncology)
Source: Indian Journal of Surgical Oncology - May 30, 2018 Category: Cancer & Oncology Source Type: research

Unusual Breast Neoplasm with Diagnostic and Management Challenges
AbstractWith the growing awareness and availability of proper screening methods, detection of breast lump is increasing globally and is now a very sensitive issue for females. The treatment of these lumps ranges from lumpectomy to wide local excision to mastectomy; hence, a proper diagnosis is very important to prevent under- or overtreatment in patients. Breast lesions are the heterogeneous diseases encompassing several distinct entities with remarkably different characteristics. While the more common forms of breast cancers are well recognized and understood better, there are many important unusual lesions and malignanci...
Source: Indian Journal of Surgical Oncology - May 24, 2018 Category: Cancer & Oncology Source Type: research

From the Desk of the Editor
(Source: Indian Journal of Surgical Oncology)
Source: Indian Journal of Surgical Oncology - May 24, 2018 Category: Cancer & Oncology Source Type: research

Etiologic and Clinicopathological Correlates of Gastric Carcinoma in the Egyptian Delta
We report a clinic-epidemiologic study of gastric carcinoma in the Egyptian delta; the age at presentation was a decade earlier than that recorded in the USA and Europe; most of the cases were sporadic, located mostly at the body. Most of the cases were presented at stage IV with poor response to neoadjuvant therapy with a poorer overall survival than that recorded in the USA and Europe. (Source: Indian Journal of Surgical Oncology)
Source: Indian Journal of Surgical Oncology - May 23, 2018 Category: Cancer & Oncology Source Type: research

A Case of Primary Intra-abdominal Synovial Sarcoma
AbstractSynovial sarcomas are relatively common intermediate-to-high-grade malignant soft tissue tumors, often with an initial indolent course. And among the sarcomas primary intra-abdominal synovial sarcoma is a relatively rare entity that may present with an abdominal mass and diagnosis is usually confirmed by immunohistochemistry. The authors report a case of a 46-year-old man who presented with a large palpable abdominal mass. Contrast-enhanced computed tomography (CT) scan showed a large well-defined heterogeneous intra-abdominal mass filling the entire pelvis and extending upwards till the subhepatic region causing d...
Source: Indian Journal of Surgical Oncology - May 22, 2018 Category: Cancer & Oncology Source Type: research

Different Presentations of Five Rare Cases of Sclerosing Stromal Tumor of the Ovary
AbstractA rare subtype of preceding neoplasm of ovary is sclerosing stromal cell tumor with few presented cases in the literature. In these case series, we describe five cases of ovarian sclerosing stromal cell tumor with different presentations in our department. Interestingly, one of our cases had elevated alfa-fetoprotein. (Source: Indian Journal of Surgical Oncology)
Source: Indian Journal of Surgical Oncology - May 19, 2018 Category: Cancer & Oncology Source Type: research

Cytoreductive Surgery in Combination with HIPEC in the Treatment of Peritoneal Sarcomatosis
AbstractCytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) is an effective treatment for peritoneal carcinomatosis, but it has been debated for peritoneal sarcomatosis. The purpose of the study is the presentation of perioperative and long-term results of CRS and hyperthermic intraoperative intraperitoneal chemotherapy in patients with peritoneal sarcomatosis. Retrospective study in a prospectively maintained database of 20 patients  that underwent 29 CRS + HIPEC for peritoneal sarcomatosis. Clinical and histopathologic variables were correlated to survival. Complete cytor...
Source: Indian Journal of Surgical Oncology - May 19, 2018 Category: Cancer & Oncology Source Type: research

Feasibility, Safety, and Surgical Outcome of Robotic Hemithyroidectomy Via Transaxillary and Retroauricular Approach: an Institutional Experience
AbstractThe aim of this observational prospective study was to determine the technical feasibility, safety, and adequacy of robotic hemithyroidectomy. From April 2015 to May 2016, 16 patients with solitary thyroid lesion underwent robotic hemithyroidectomy using theDa Vinci ® Si Surgical system. Patients were observed and data were recorded on surgical time, blood loss, complications, and functional outcome of the patients. A total of 16 patients (3 males and 13 females; mean age 39.9  years) underwent robotic hemithyroidectomy after evaluation for solitary thyroid nodule with a mean nodule size of 2.2 &plu...
Source: Indian Journal of Surgical Oncology - May 19, 2018 Category: Cancer & Oncology Source Type: research

Recurrent Retroperitoneal Liposarcoma: a Case Report and Literature Review
AbstractThis is a case report of a 61-year-old male patient, presented with fifth recurrence of retroperitoneal liposarcoma and operated for six times. Literature review on retroperitoneal liposarcoma biology, recurrence pattern, role of surgery in primary tumor, and recurrent tumor, adjuvant therapy, role of multivisceral resection, and palliative surgery. (Source: Indian Journal of Surgical Oncology)
Source: Indian Journal of Surgical Oncology - May 19, 2018 Category: Cancer & Oncology Source Type: research

Carcinosarcoma of Breast Mimicking Breast Abscess
AbstractCarcinosarcoma, a tumor having both carcinomatous and sarcomatous elements, occurring in the breast, is a rare condition. The tumor consists of both epithelial and mesenchymal cell lines and tends to behave aggressively. It has clinical features like that of invasive breast carcinoma but sometimes there can be diagnostic confusion as it can mimic or present as breast abscess. Treatment is multimodal. Surgery plays the vital role. Post-op radiation and chemo are indicated. Hormone therapy is usually inapplicable as most of the time, it is hormone receptor negative. (Source: Indian Journal of Surgical Oncology)
Source: Indian Journal of Surgical Oncology - May 19, 2018 Category: Cancer & Oncology Source Type: research

Managing Synchronous Liver Metastases in Colorectal Cancer
AbstractThe most common site of blood-borne metastases from colorectal cancers (CRC) is the liver. Resection of (liver) metastases is a part of standard treatment of metastatic colorectal cancer. Hepatic resection is the first-line treatment of liver metastases, with 5-year survival rates between 25 and 58%. The enhanced efficacy of systemic chemotherapeutic regimens has increased tumor response rates and improved the progression-free and overall survival of patients with these malignancies. In approximately 20% of patients with initially unresectable liver metastases, the metastases may become resectable after administrat...
Source: Indian Journal of Surgical Oncology - May 18, 2018 Category: Cancer & Oncology Source Type: research

Vasoformative Lesions in Mediastinal Mixed Germ Cell Tumors: an Interesting Account of Two Cases Spanning the Benign to Malignant Spectrum
AbstractExtragonadal germ cell tumors are most commonly encountered in the anterior mediastinum. The presence of sarcomatous malignancies in these tumors is a rare phenomenon that adversely impacts patient prognosis because of poor response to conventional cisplatin-based chemotherapy. Even more unusual is the presence of florid benign somatic proliferations that overshadow the germ cell component, often resulting in misdiagnosis and inappropriate management. Two young male patients aged 17 and 28  years respectively presented with mass in the anterior mediastinum. Histopathology of both cases revealed mixed germ cell...
Source: Indian Journal of Surgical Oncology - May 18, 2018 Category: Cancer & Oncology Source Type: research

A Prospective Observational Study of Breast Lumps in Adolescent Girls: Tertiary Care South Indian Teaching Hospital Experience
AbstractThe aim of the current study was to assess the incidence and varying clinical presentations of benign breast lumps in adolescent age group in a Tertiary care Medical College Hospital. This was a prospective, observational study of 6-year duration (2011 to 2017) conducted in a Medical College, South India. All adolescent age group patients visiting the outpatient department (OPD) with complaints of breast lump were enrolled into the study. Triple assessment comprising of clinical examination, imaging, and core biopsy was used for diagnosis and identification of type of tumor. Management of tumors was based on pathol...
Source: Indian Journal of Surgical Oncology - May 18, 2018 Category: Cancer & Oncology Source Type: research

Desmoplastic Fibroma of Bone: a Case Series and Review of Literature
This article presents a report on three cases of desmoplastic fibroma in the proximal humerus, distal femur, and neck femur region. The varied radiographic features and the management of the three cases are described in detail. All the three patients were treated by extended curettage. Follow-up ranged from 2 to 5  years. There were no local or systemic recurrence until the last follow-up. Tumor resection with adequate margins is the preferred treatment, although extended curettage can be an acceptable alternative treatment modality when resection is not possible or acceptable. (Source: Indian Journal of Surgical Oncology)
Source: Indian Journal of Surgical Oncology - May 18, 2018 Category: Cancer & Oncology Source Type: research

Recent Strategies and Paradigm Shift in Management of Hepatic Metastasis from Colorectal Cancer
AbstractThe liver is the most common site for metastasis from colorectal cancers (CRCs). There are so many new armamentarium, which have increased the life expectancy and progression-free survival. There are various available guidelines, such as NCCN, ESMO, and ASCO, which provide an insight into the latest modalities and new protocols. We have tried to elucidate into paradigm shift of the management. (Source: Indian Journal of Surgical Oncology)
Source: Indian Journal of Surgical Oncology - May 18, 2018 Category: Cancer & Oncology Source Type: research

Solid Pseudopapillary Neoplasm of the Pancreas Clinicopathological Characteristics and Long-Term Outcome: a Single-Center Experience
This study aims to share our experience and to describe management of the disease. We retrospectively evaluated patients 13 patients diagnosed with SPT on histopathological examination of resected specimen. Data on their clinicopathological, management-related factors, and follow-up was collected. All the patients were females, with a median age of 20  years. Abdominal pain was the most common presentation. The mean tumor size was 6.5 cm and majority of tumors were located in the head region. R0 resection was obtained in all the patients. All patients were disease-free with a median follow-up of 68 months. E...
Source: Indian Journal of Surgical Oncology - May 18, 2018 Category: Cancer & Oncology Source Type: research

HATRICK —Synchronous Triple Primary Tumors of Thyroid
We present a case of a 27-year-old female patient who presented with a painless, gradually progressive right-sided neck swelling for the last 1 year with no systemic complaints. Examination revealed a 4 ×  3-cm, firm, smooth surfaced swelling on right lobe of thyroid. USG neck showed a hypoechoic solid nodule on the right lobe and the left lobe was normal. FNAC showed features of adenomatous colloid nodule, Bethesda II. Right hemithyroidectomy specimen revealed evidence of triple tumors—not otherwis e-specified (NOS) tumor, papillary carcinoma thyroid, and medullary carcinoma thyroid, which w...
Source: Indian Journal of Surgical Oncology - May 18, 2018 Category: Cancer & Oncology Source Type: research

Sarcomatoid Carcinoma of Urinary Bladder: a Case Report
We report a case with sarcomatoid variant of bladder urothelial carcinoma and review the pathologic features. A 65-year-old male on evaluation of long standing obstructive voiding symptoms and intermittent hematuria found to have a bladder mass. Magnetic resonance urography revealed a 35  × 45 mm mass at dome of urinary bladder with perivesical fat infiltration. He underwent transurethral resection and histopathology revealed pT1 high-grade malignant spindle cell tumor. He underwent radical cystoprostatectomy with bilateral extended pelvic lymphadenectomy with EPLND with ileal conduit urine diversi...
Source: Indian Journal of Surgical Oncology - May 16, 2018 Category: Cancer & Oncology Source Type: research

Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC): Initial Experience from Indian Centers and a Review of Literature
AbstractCytoreductive surgery and HIPEC is a therapeutic option that benefits only selected patients with peritoneal metastases (PM). New treatments like pressurized intraperitoneal aerosol chemotherapy (PIPAC) have been developed to overcome some limitations of intraperitoneal chemotherapy and treat patients who are not eligible for a curative approach. The safety and feasibility of the procedure in the first few Indian patients treated with PIPAC, and the technique and the set-up required for PIPAC are described here. From May 2017 to August 2017, data was collected prospectively for all patients undergoing PIPAC at thre...
Source: Indian Journal of Surgical Oncology - May 16, 2018 Category: Cancer & Oncology Source Type: research

Esophageal Metallic-Stent Migration: a Rare Cause of Anal Pain in a Patient with Gastric Cancer
AbstractStents are a great development for esophageal fistula treatment; however, stent migration is a frequent complication. A stent migration that caused anal pain is presented. A 79-year-old man with poorly differentiated gastric carcinoma was submitted to a total gastrectomy with a Roux-en-Y esophagojejunostomy. The patient developed an anastomosis leakage 3 months after surgery; a fixed metallic stent was used as treatment with good evolution. Five months after the stent (and 8 months after gastrectomy), the patient returned to the emergency department with acute incapacitating anal pain; the pain was caused by the mi...
Source: Indian Journal of Surgical Oncology - May 16, 2018 Category: Cancer & Oncology Source Type: research

Multiple Gastrointestinal Cancers in a Single Patient —a Rare Clinical Entity
AbstractMultiple gastrointestinal cancers in a single patient is a rare entity. In our study, we are showing the clinical presentation and management of these patients. A fifty-nine-year-old asthenic male (already treated case of metachronous colorectal cancer in 2008 and 2011) presented with complaints of generalized weakness and fatigue. Strong family history was present with two of his first-degree relatives having diagnosed with gastrointestinal cancer at the age
Source: Indian Journal of Surgical Oncology - May 16, 2018 Category: Cancer & Oncology Source Type: research

Malignant Peripheral Nerve Sheath Tumor of the Parotid Gland
AbstractMalignant peripheral nerve sheath tumor (MPNST) refers to spindle cell sarcomas arising from or separating in the direction of cells of peripheral nerve sheath. The MPNST of the parotid gland is an extremely rare tumor, accounts for
Source: Indian Journal of Surgical Oncology - May 16, 2018 Category: Cancer & Oncology Source Type: research