Uterine Assessment for Transvaginal Procedures : A Different Perspective in Clinical Practice
(Source: Indian Journal of Surgical Oncology)
Source: Indian Journal of Surgical Oncology - October 23, 2020 Category: Cancer & Oncology Source Type: research

Endobronchial Carcinoids: Surgical Outcome in 100 Consecutive Patients and Factors Affecting Lung Preservation
AbstractBronchial carcinoids are slow-growing tumours of the neuroendocrine family. Most of them have a benign course with excellent outcome after complete resection. Due to their location in the primary bronchi, adequate resection with lung preservation requires considerable technical expertise. In this paper we present our surgical experience with endobronchial carcinoids and analyse the factors that predict possibility of lung preservation surgery. Retrospective analysis of a prospectively maintained database of patients operated for endobronchial carcinoids for the period March 2012 to September 2019 was carried out. D...
Source: Indian Journal of Surgical Oncology - October 21, 2020 Category: Cancer & Oncology Source Type: research

To Evaluate the Accuracy of Axillary Staging Using Ultrasound and Ultrasound-Guided Fine-Needle Aspiration Cytology (USG-FNAC) in Early Breast Cancer Patients —a Prospective Study
AbstractIn breast cancer, axillary lymph node involvement directly impacts the patient survival and prognosis. Sentinel lymph node biopsy (SLNB) is a procedure of choice for axillary staging in early breast cancer. Currently, management options for axilla management are axillary lymph node dissection and sentinel node biopsy in node positive and in node negative respectively. Accuracy of current clinical methods for evaluating axilla is low. Hence, to select patients for appropriate procedure, ultrasound (USG) combined with fine-needle aspiration cytology (USG-FNAC) using vascular pedicle –based nodal mapping method ...
Source: Indian Journal of Surgical Oncology - October 19, 2020 Category: Cancer & Oncology Source Type: research

Outcomes of Cancer Surgery During the COVID-19 Pandemic: Preparedness to Practising Continuous Cancer Care
We report cancer surgery outcomes taking into account the acuity of the COVID-19 situation. A prospectively maintained database of the Department of Surgical Oncology was analysed from 1st May to 30th June, 2020, to evaluate the perioperative outcomes, morbidity and mortality following major surgical procedures. A total of 359, preoperatively, tested negative for COVID-19 underwent surgery. Median age was 52  years with 26.7% (n = 96) above the age of 60 years. Sixty-one percent (n = 219) patients were American Society of Anaesthesiology grades II–III. As per surgical complexity ...
Source: Indian Journal of Surgical Oncology - October 19, 2020 Category: Cancer & Oncology Source Type: research

Expression of PDL1 and Her2neu in Gastric and Gastroesophageal Junction Adenocarcinoma
We examined 100 biopsy and resection samples of gastric and gastroesophageal junction carcinomas for PD-L1, Her2neu, and p53 protein expressions using immunohistochemistry. Scorings were done based on intensity and percentage of tumor cells expressing the markers. Follow-up and survival analyses were done wherever data was available. PD-L1 and Her2neu were seen in 37% and 38% respectively. The analysis showed PD-L1 expression was significantly associated with depth of invasion (p = 0.0007), nodal metastasis (p = 0.0003), and AJCC staging (p = 0.0085). Her2neu negative including equ...
Source: Indian Journal of Surgical Oncology - October 16, 2020 Category: Cancer & Oncology Source Type: research

A Retrospective Cohort Study of Coexistence of Carcinoma and Tuberculosis of Colon: 12-Year Experience
AbstractCoexistence of carcinoma colon and tuberculosis is rare. The aim of this study is to present our 12-year experience on colonic carcinoma with coexisting colonic TB. Histopathology and imaging records of 189 patients of colonic carcinoma patients who underwent treatment in surgical unit 6 in our institute between January 2006 and December 2017 were reviewed. In 7 patients, histopathology and/or imaging studies were suggestive of coexistence of colonic carcinoma and tuberculosis. Fifteen cases of colonic tuberculosis were also reviewed. Descriptive statistics were used to summarize the data. Colonoscopic biopsy was s...
Source: Indian Journal of Surgical Oncology - October 14, 2020 Category: Cancer & Oncology Source Type: research

Colorectal Services in Covid-19 Times: Minimally Invasive Surgery and Enhanced Recovery, the Need of the Hour
AbstractThe health services across the world have been deeply impacted by the ongoing COVID-19 pandemic which has resulted in diversion of resources to testing, isolating and treating COVID-19 patients. This meant cutting down resources and manpower away of various healthcare facilities and severely hampering the functioning of various cancer services across the world. It is however, important to understand, cancer itself is a life-threatening condition, and there is a need to continue running cancer care services, at least for those who needed the most. Various clinical societies have put forward guidelines and protocols ...
Source: Indian Journal of Surgical Oncology - October 14, 2020 Category: Cancer & Oncology Source Type: research

A Case Series on Malignant Peripheral Nerve Sheath Tumour of Cervix: an Institutional Report
(Source: Indian Journal of Surgical Oncology)
Source: Indian Journal of Surgical Oncology - October 13, 2020 Category: Cancer & Oncology Source Type: research

𝛽-Catenin—a Possible Prognostic Molecular Marker for Recurrence in Histopathologically Negative Surgical Margin of Oral Cancer
AbstractThe locoregional recurrence in oral cancer is not predicted by the histopathological parameters solely as the normal morphological looking cells harbor the genomic instability which acts as the potential tumor cells for recurrence in future. Therefore, there is an urgent need of the biomarker for prognostic stratification of patients with high risk of disease recurrence and appropriate management. Eighty oral squamous cell carcinoma (OSCC) patients were included in the study during the period 2012 to 2014 at Apollo Hospitals and Kalinga Institute of Medical sciences, Bhubaneswar. OSCC tissue samples were collected ...
Source: Indian Journal of Surgical Oncology - October 11, 2020 Category: Cancer & Oncology Source Type: research

Low Cost, Low Dose, Oral, Neoadjuvant Chemotherapy Protocol in Locally Advanced Borderline Oral Cancers —Feasibility Study
AbstractA vast majority of oral cancer patients in developing countries present in an advanced stage with borderline resectable/inoperable stage to busy resource-constrained tertiary cancer centers. Conventional chemotherapy protocols are associated with issues like toxicity, tolerance, cost, and compliance. The present study was conducted to assess the feasibility of low-cost home-based chemotherapy options. Single-arm feasibility study was done in borderline resectable/inoperable oral cancer patients. Home-based oral neoadjuvant chemotherapy consisting of oral methotrexate 15  mg/m2 once a week and oral celecoxib 20...
Source: Indian Journal of Surgical Oncology - October 10, 2020 Category: Cancer & Oncology Source Type: research

Bilobed PMMC in Females: Our Challenging yet Meritorious Experience
AbstractThe gold standard reconstructive options for full-thickness defect of the oral cavity after resection of malignant lesions are the free flaps. But in developing nations due to resource constraints, it cannot be offered to all. Hence, pectoralis major myocutaneous (PMMC) flap as bilobed flaps is most commonly used. Bilobed flaps are technically demanding, and in females, it is more challenging due to higher complication rates especially in large breasts. There has been no major reported data evaluating outcomes of bilobed PMMC in females. This is a retrospective evaluation of outcomes of patients who underwent the b...
Source: Indian Journal of Surgical Oncology - October 7, 2020 Category: Cancer & Oncology Source Type: research

Bilateral Symmetric Sporadic Osteofibrous Dysplasia: an Unusual Case
(Source: Indian Journal of Surgical Oncology)
Source: Indian Journal of Surgical Oncology - October 7, 2020 Category: Cancer & Oncology Source Type: research

Osteosarcoma with Tongue Metastasis: a Rare Case Report
(Source: Indian Journal of Surgical Oncology)
Source: Indian Journal of Surgical Oncology - October 2, 2020 Category: Cancer & Oncology Source Type: research

Who Needs Level III Lymph Node Dissection in Carcinoma Breast —Study from a Tertiary Care Center
AbstractIn Indian females, breast cancer is the most common cancer with a late stage of presentation leading to one-third of patients undergoing modified radical mastectomy (MRM). Our study is undertaken to find out predictors of level III axillary lymph node metastasis in breast cancer and who needs complete axillary lymph node dissection (ALND). Retrospective study of 146 patients who undergone MRM or breast-conserving surgery (BCS) with complete ALND at Kidwai Memorial Institute of Oncology was done, and data was analyzed to find out the frequency of level III lymph nodes and the demographic relation and its relation to...
Source: Indian Journal of Surgical Oncology - October 1, 2020 Category: Cancer & Oncology Source Type: research

Validation of Sentinel Lymph Node Biopsy Technique Using Dual Tracer Technique in Post Lumpectomy Early Breast Cancer Patients
AbstractSentinel lymph node biopsy (SLNB) is the gold standard for the evaluation of axilla in clinically node-negative early breast cancers. There is limited data on the role and efficacy of the same in the post lumpectomy scenario. This prospective interventional study was conducted over 1  year on 30 post lumpectomy pT1/2 cN0 patients. SLNB was performed by preoperative lymphoscintigram using technetium-labeled human serum albumin followed by intraoperative blue dye injection. Sentinel nodes were identified based on blue dye uptake and gamma probe and sent for intra operative frozen section. Completion axillary nod...
Source: Indian Journal of Surgical Oncology - October 1, 2020 Category: Cancer & Oncology Source Type: research

Case Report Writing
(Source: Indian Journal of Surgical Oncology)
Source: Indian Journal of Surgical Oncology - October 1, 2020 Category: Cancer & Oncology Source Type: research

Bilateral Primary Ovarian Clear Cell Carcinoma in an Iranian Woman: a Case Report
(Source: Indian Journal of Surgical Oncology)
Source: Indian Journal of Surgical Oncology - September 30, 2020 Category: Cancer & Oncology Source Type: research

Delayed Management of Chemoport Complication
(Source: Indian Journal of Surgical Oncology)
Source: Indian Journal of Surgical Oncology - September 29, 2020 Category: Cancer & Oncology Source Type: research

Surgical and Oncological Outcomes in Locally Advanced Thymoma
This study aimed at reporting the surgical management of locally advanced thymoma (Masaoka stages III and IVA) and evaluating the factors predicting the survival. This is a retrospective analysis of patients operated for locally advanced thymoma from March 2012 to December 2019 in a thoracic surgery center in India. An analysis of all perioperative variables including complications was carried out. The influence of various predictors on survival was assessed by log-rank test. Out of total 54 patients, 42 (77.8%) had stage III and 12 (22.2%) had stage IVA. Upfront surgery was done in 34 (63%) patients, and induction chemoth...
Source: Indian Journal of Surgical Oncology - September 28, 2020 Category: Cancer & Oncology Source Type: research

Treatment Outcomes of Early Carcinoma Cervix Before and After Sub-specialization
This study aimed to compare the treatment outcomes in carcinoma cervix before and after gynecologic oncology sub-specialization at a tertiary care hospital, in India. This was a retrospective cohort study comparing women with operable cervical cancer who underwent radical hysterectomy before and after gynecologic oncology sub-specialization. Electronic medical records of women operated for early carcinoma cervix between 2001 and 2010 and 2011 –2015 were reviewed and compared for treatment and oncological outcomes. Seventy-four patients were operated over 5 years after sub-specialization as against 59 over 10&nbs...
Source: Indian Journal of Surgical Oncology - September 27, 2020 Category: Cancer & Oncology Source Type: research

Pattern of Lymph Node Metastasis in Endometrial Cancer: a Single Institution Experience
AbstractSurgical staging remains the standard primary treatment of endometrial cancer. Lymph node metastasis is the most important prognostic factor which helps in deciding adjuvant treatment. Extensive lymphadenectomy is associated with increased incidence of morbidity. The role of lymphadenectomy in surgical staging is still controversial especially in early stage disease. The surgico-pathological pattern of 155 patients with apparently stage 1 cancer endometrium who had undergone pelvic alone or pelvic and para-aortic lymph node dissection and its correlation to the grade of the tumour, myometrial infiltration and prese...
Source: Indian Journal of Surgical Oncology - September 27, 2020 Category: Cancer & Oncology Source Type: research

Role of Prophylactic Coronoidectomy in Oral Cancer Treatment: a Retrospective Cohort Study
AbstractTo evaluate the effectiveness of coronoidectomy to prevent trismus in patients undergoing primary surgery for oral cancer. Patients who underwent primary surgery for oral gingivo-buccal cancers were analysed. Group 1 (G1) consists of patients who underwent coronoidectomy during the primary ablative procedure and group 2 (G2) who underwent standard ablative surgery without coronoidectomy. Post-treatment maximum interincisor opening was compared between the two groups. Sixty-four patients were included, 31 in G1 and 33 patients in G2. Overall, 81% had reduction in mouth opening at the time of evaluation. The post-tre...
Source: Indian Journal of Surgical Oncology - September 25, 2020 Category: Cancer & Oncology Source Type: research

Neurovascular Complications After Neck Dissection: a Prospective Analysis at a Tertiary Care Centre in South India
AbstractOwing to high incidence of oral cancers in India, neck dissection is the most commonly performed procedure in any head and neck oncology setup. This surgery is particularly prone to various neurovascular complications due to intricate anatomy of neck, but the exact incidence has been studied less especially in Indian subcontinent. A prospective observational study was done on 105 patients of oral cancer who underwent neck dissection at Regional Cancer Centre, Trivandrum, and various short-term and long-term neurovascular complications were recorded. There was high temporary praxia of marginal mandibular and greater...
Source: Indian Journal of Surgical Oncology - September 25, 2020 Category: Cancer & Oncology Source Type: research

COVID-19 Outbreak and Oncological Surgery Practice
In this study, we aimed to address cancer-related operations during the COVID-19 outbreak. We retrospectively reviewed 26 patients who had undergone cancer surgeries admitted from March 13 to May 13, 2020, during the COVID-19 epidemic at Istanbul Bagcilar Training and Research Hospital, as a pandemic hospital. A total of 26 cases of COVID-19 were enrolled in the study. Seventeen (65%) were female, and 9 (35%) were male. The mean age was 52.4 (range 28 –74). The mean body mass index (BMI) is 27.8 kg/m2 (range 17.6 –34.0). Eight of them had comorbidities. 7 patients needed an intensive care unit (ICU). Only ...
Source: Indian Journal of Surgical Oncology - September 25, 2020 Category: Cancer & Oncology Source Type: research

A Novel and Simple Technique of Reconstructing the Central Arch Mandibular Defects —a Solution During the Resource-Constrained Setting of COVID Crisis
AbstractThe current COVID 19 pandemic has a major impact on healthcare delivery globally. Oral cancer involving anterior arch of mandible is difficult to reconstruct and ideally, requires free fibular osteomyocutaneous flap. During this time of resource constraint situation, these free flaps are not a great choice, as it increases exposure of both patient and surgical team to the deadly virus. We are describing a novel method of reconstruction after resection of oral cancer involving anterior arch of mandible. In this new technique, we have reconstructed central arch defect by hanging bipaddle pectoralis major myocutaneous...
Source: Indian Journal of Surgical Oncology - September 24, 2020 Category: Cancer & Oncology Source Type: research

Efficacy of Periareolar Versus Peritumoral Injection of TC99-Labelled Sulphur Colloid and Methylene Blue Dye for Detection of Sentinel Lymph Node in Patients with Early Breast Cancer: a Comparative Study
AbstractSentinel lymph node biopsy using dual methods of blue dye and radioactive isotope is what is practised as the standard of care at most of the centres. The combined use of radioactive colloid and blue dye injection is considered the gold standard for axillary sentinel lymph node biopsy in breast cancer with a 97% accuracy rate. The aim of this study is to determine the optimal injection site for methylene blue dye and Tc99-labelled sulphur colloid for sentinel lymph node biopsy in early breast cancer. In both periareolar and peritumoral groups of patients, overall rate of identifying sentinel lymph node (hot, blue a...
Source: Indian Journal of Surgical Oncology - September 24, 2020 Category: Cancer & Oncology Source Type: research

Robot-Assisted Esophagectomy After Neoadjuvant Chemoradiation —Current Status and Future Prospects
AbstractMultimodality treatment with neoadjuvant chemoradiation followed by surgery has become the standard of care for esophageal cancer. In the recent years, there has been a shift in focus of surgical approach from open esophagectomy to minimally invasive esophagectomy. Robot-assisted esophagectomy is being performed more often in centers across the world. However, there is limited data on role of robot-assisted esophagectomy in patients who have received neoadjuvant chemoradiation. Initial reports have shown that integrating neoadjuvant therapy to robot-assisted esophagectomy is feasible and safe. With the growing popu...
Source: Indian Journal of Surgical Oncology - September 24, 2020 Category: Cancer & Oncology Source Type: research

Flap Fixation as a Technique for Reducing Seroma Formation in Patients Undergoing Modified Radical Mastectomy: an Institutional Experience
This study is intended at creating data on whether flap fixation has any role in reducing the seroma formation in patients undergoing the modified radical mastectomy. A prospective comparative study was conducted among 61 patients scheduled for modified radical mastectomy from 1st of January 2017 to 31st of December 2017. Patients were divided into two groups. In the flap fixation group (N = 30), the skin flaps were sutured to the pectoral muscle with Vicryl 3–0 sutures, and in the control group (N = 31), the wound was closed in the conventional methods at the edges. Closed suction drain w...
Source: Indian Journal of Surgical Oncology - September 22, 2020 Category: Cancer & Oncology Source Type: research

Growing Teratoma Syndrome a Rare Clinical Entity: Two Decades Management Experience from the Regional Cancer Institute
AbstractTo study the clinical, biochemical, radiological, pathological characteristics, surgical treatment details, and follow-up of growing teratoma syndrome (GTS) patients. This is a retrospective study of GTS treated in the Department of Gynaecological Oncology at a regional cancer institute from March 2000 to March 2020. A total of 303 cases of germ cell ovarian cancers were treated, and 8 (2.6%) of 303 cases recurred as GTS during this period. The patients presenting with recurrent GTS were studied for clinical, radiological, tumor markers, surgical management, histopathology, and post-operative follow-up details that...
Source: Indian Journal of Surgical Oncology - September 22, 2020 Category: Cancer & Oncology Source Type: research

Cancer Care in the Era of COVID-19: Changing Rules of Engagement of Social Media Applications to Support Cancer Patients in LMICs
(Source: Indian Journal of Surgical Oncology)
Source: Indian Journal of Surgical Oncology - September 22, 2020 Category: Cancer & Oncology Source Type: research

Can Post-Treatment MRI Features Predict Pathological Circumferential Resection Margin (pCRM) Involvement in Low Rectal Tumors
AbstractThe MERCURY II study demonstrated the use of MRI-based risk factors such as extramural venous invasion (EMVI), tumor location, and circumferential resection margin (CRM) involvement to preoperatively predict pCRM (pathological CRM) outcomes for lower rectal tumors in a mixed group of upfront operated patients and patients who received neoadjuvant treatment. We aim to study the applicability of results of MERCURY II study in a homogeneous cohort of patients who received neoadjuvant chemoradiation (NACTRT) prior to surgery. After Institutional Review Board approval, post NACTRT restaging MRI of 132 patients operated ...
Source: Indian Journal of Surgical Oncology - September 21, 2020 Category: Cancer & Oncology Source Type: research

Validation of an Intelligibility Assessment Tool in an Indian Language for Perceptual Speech Analysis in Oral Cancer Patients
This study aimed to develop a speech intelligibility tool in Malayalam, an Indian language, based on the perceptual analysis. The tool had components of vowel, consonant, word, passage, and overall intelligibility. After face and content validation, a sample of 30 consecutive oral cancer patients underwent preliminary testing for internal consistency, inter- and intra-rater reliability, concurrent, and known-group validity. Subsequent validation was done in 80 T1 –T4 patients from two centers. The scale had a high level of internal consistency; the Cronbach’s alpha was 0.847 and good intra-rater and inter-rater...
Source: Indian Journal of Surgical Oncology - September 18, 2020 Category: Cancer & Oncology Source Type: research

Versatility of Rectus Abdominis Myocutaneous Flap in Primary Reconstruction of Defects in Surgical Oncology
This study demonstrates the versatility and reliability of the VRAM flap in primary reconstruction of defects in surg ical oncology. Optimization of risk factors such as diabetes, smoking, and weight gain can reduce flap loss and improve outcomes. (Source: Indian Journal of Surgical Oncology)
Source: Indian Journal of Surgical Oncology - September 16, 2020 Category: Cancer & Oncology Source Type: research

Island Nasolabial Flap for Tongue Reconstruction: Locoregional Flap of Choice and an Alternative to Free Flap for Tongue Cancer
AbstractReconstruction following excision for tongue cancer carries important functional consequences. Island nasolabial flap (NLF) is robust and oncologically safe and has a good functional outcome, identical to free flap reconstruction. We retrospectively analyzed the data of 11 tongue cancer patients operated between January 2019 and August 2019. Surgical resection and neck dissection followed by immediate reconstruction by island NLF were done. Post-operative functional outcome assessed using the University of Washington Quality of Life Questionnaire. Age of patients ranged between 39 and 70  years. All patients h...
Source: Indian Journal of Surgical Oncology - September 16, 2020 Category: Cancer & Oncology Source Type: research

Robotic Total Mesorectal Excision for Rectal Cancer: Short-Term Oncological Outcomes of Initial 178 Cases
AbstractEmerging techniques in minimally invasive rectal resection include robotic total mesorectal excision (R-TME). The Da Vinci Surgical System offers precise dissection in narrow and deep confined spaces and is gaining increasing acceptance during recent times. The aim of this study is to analyse our initial experience of R-TME with Da Vinci Xi platform in terms of perioperative and oncological outcomes in the context of data from recently published randomised ROLARR trial amongst minimally invasive novice surgeons. Patients who underwent R-TME or tumour specific mesorectal excision for rectal cancer between May 2016 a...
Source: Indian Journal of Surgical Oncology - September 7, 2020 Category: Cancer & Oncology Source Type: research

Desk of the Editor
(Source: Indian Journal of Surgical Oncology)
Source: Indian Journal of Surgical Oncology - September 7, 2020 Category: Cancer & Oncology Source Type: research

Minimal Access Surgery for Thymoma
This article aims to discuss the various minimally invasive approaches currently being employed for thymomas. (Source: Indian Journal of Surgical Oncology)
Source: Indian Journal of Surgical Oncology - September 4, 2020 Category: Cancer & Oncology Source Type: research

Negative Prognostic Implication of TERT Promoter Mutations in Human Papillomavirus –Negative Tonsillar Squamous Cell Carcinoma Under the New 8th AJCC Staging System
AbstractTelomerase reverse transcriptase gene promoter (TERTp) mutation is a potential candidate for pathogenesis and therapeutic target of tonsillar squamous cell carcinomas (TSCCs) in association with human papillomavirus (HPV). Their clinical relevance has not been validated under the new 8th American Joint Committee on Cancer (AJCC) staging system. We analyzed real-time peptide nucleic acid –mediated PCR and sequencing methods (TERTp mutation) and real-time PCR-based assay (HPV) in 80 surgically resected TSCCs. The 8th edition staging system improved the stratification of the early and advanced stages and between...
Source: Indian Journal of Surgical Oncology - September 4, 2020 Category: Cancer & Oncology Source Type: research

Differentiating Benign from Malignant Adrenocortical Tumors by a Single Morphological Parameter —a Clinicopathological Study on 837 Adrenocortical Neoplasias
AbstractThe morphological differentiation between benign and malignant adrenocortical tumors is an ongoing problem in diagnostic pathology. In recent decades the complex scoring systems have been widely used to calculate the probability of malignancy in adrenocortical tumors on the basis of a variety of histomorphological parameters. We herewith present a substantially simplified method to diagnose adrenocortical carcinoma by a single histomorphological parameter on a consecutive series of more than 800 adrenocortical tumors. Between January 2000 and May 2019, altogether 2305 adrenalectomies for of all types of diseases we...
Source: Indian Journal of Surgical Oncology - September 4, 2020 Category: Cancer & Oncology Source Type: research

Sensory Changes and Postmastectomy Pain Following Preservation of Intercostobrachial Nerve in Breast Cancer Surgery: a Prospective Randomized Study
AbstractSurgery for breast cancer leads to sensory changes and persistent pain in about 20 –60% of patients and is usually attributed to section of the intercostobrachial nerve (ICBN). However, the opinion is divided about the benefit of preservation of ICBN. Hence, this study was designed to assess the role of preservation of ICBN on sensory changes and acute and persistent pain follow ing mastectomy. The study was conducted on patients undergoing modified radical mastectomy for breast cancer. At the time of surgery, ICBN was sacrificed in group I (N = 29), and preserved in group II (N = ...
Source: Indian Journal of Surgical Oncology - September 4, 2020 Category: Cancer & Oncology Source Type: research

Superior Vena Cava Resection in Locally Advanced Thymoma —Surgical and Survival Outcomes
This study was aimed at reporting the surgical management of superior vena cava invasion in patients with locally advanced thymoma and to evaluate surgical and survival outcomes. This is a retrospective analysis of 12 patients operated for superior vena cava resection for locally advanced thymoma over 8  years in a thoracic surgery centre in India. An analysis of peri-operative variables including complications was carried out. The influence of various predictors on survival was assessed by log-rank test. Intra-operatively, superior vena cava (SVC) alone was involved in 3 (25%) cases, SVC with BCV involvement was ther...
Source: Indian Journal of Surgical Oncology - September 3, 2020 Category: Cancer & Oncology Source Type: research

Granular Cell Tumor of Vulva: Mesquerading Reactive Histiocytic Proliferation
(Source: Indian Journal of Surgical Oncology)
Source: Indian Journal of Surgical Oncology - September 2, 2020 Category: Cancer & Oncology Source Type: research

Prospective Study Comparing Clinical vs Indocyanine Green Fluorescence –Based Assessment of Line of Transection in Robotic Rectal Cancer Surgery—Indian Study
AbstractAnastomotic leakage continues to be the most feared postoperative complications in rectal surgery with negative impact on both short- and long-term outcomes. Fortunately, new surgical strategies have helped to offset this complication and improve surgical outcomes. Traditionally, perfusion is assessed by intraoperative visual judgment by the surgeon. These subjective methods lack predictive accuracy resulting in either excess or insufficient colonic resection. Indocyanine green (ICG) fluorescence has shown promise in identifying the adequacy of perfusion. After injection of ICG, the system projected high-resolution...
Source: Indian Journal of Surgical Oncology - August 31, 2020 Category: Cancer & Oncology Source Type: research

Selective Neck Dissection in Oral Cavity Cancer Is Not Without Morbidity
The objective of this study is to analyze the morbidity of selective neck dissection (SND) in oral cavity squamous cell carcinoma (OCSCC). This is a cross-sectional study of 106 consecutive patients with T1 and T2 (AJCC seventh edition) stage cancers. Morbidity in terms of scar characteristics, cervical lymphedema, sensation, shoulder dysfunction, and smile asymmetry were analyzed. Scar outcomes were inferior in terms of poor complexion in 15 patients (14.2%), poor texture in 25 patients (23.6%), limited skin movement in 9 patients (8.5%), soft tissue deficit in 13 patients (12.3%), and lymphedema in 14 patients (13.2%). S...
Source: Indian Journal of Surgical Oncology - August 31, 2020 Category: Cancer & Oncology Source Type: research

Neuropeptide Substance P Enhances Inflammation-Mediated Tumor Signaling Pathways and Migration and Proliferation of Head and Neck Cancers
AbstractHead and neck cancers (HNC) are extremely aggressive, highly recurrent, and the sixth most common cancer worldwide. Neuropeptide substance P, along with its primary receptor, neurokinin-1 (NK-1R), is overexpressed in HNC and is a central player in inflammation and growth and metastasis of several cancers. However, the precise SP-mediated signaling that promotes HNC progression remains ill defined. Using a panel of HNC lines, in this study, we investigated the effects of SP on proliferation and migration of HNC. Tumor cells were also treated with SP and alterations in inflammatory cytokines and chemokines, and their...
Source: Indian Journal of Surgical Oncology - August 31, 2020 Category: Cancer & Oncology Source Type: research

Minimal Invasive Esophagectomy —a New Dawn of EsophagealSurgery
AbstractSurgery is the mainstay of esophageal cancer. However, esophagectomy is a major surgical trauma on a patient with high morbidity and mortality. The intent of minimally invasive esophagectomy (MIE) is to decrease the degree of surgical trauma and perioperative morbidity associated with open surgery, and provide faster recovery and shorter hospital stay with the equivalent oncological outcome. It also allows for lesser pulmonary morbidity, less blood loss, less pain, and a better quality of life. MIE is safe and effective but has a steep learning curve with high technical expertise. Recently, it is increasingly accep...
Source: Indian Journal of Surgical Oncology - August 31, 2020 Category: Cancer & Oncology Source Type: research

Primary Non-Hodgkin Lymphoma of Prostate: a Case Report
(Source: Indian Journal of Surgical Oncology)
Source: Indian Journal of Surgical Oncology - August 30, 2020 Category: Cancer & Oncology Source Type: research

Is Survival with Conservative Breast Therapy Becoming Superior to That with Modified Radical Mastectomy Alone for the Treatment of Early Breast Cancer in This Era?
This study aims to assess survival rates in early breast cancer patients treated by conservative breast therapy (CBT), including radiotherapy, compared with those treated by modified radical mastectomy (MRM) alone. The South Egypt Cancer Institute and the Assiut University Oncology Department patients ’ records, from January 2010 to December 2017, were searched for T1-2N0-1M0 breast cancer patients treated by CBT or MRM. Patients who did not receive chemotherapy were excluded to reduce the treatment variation. The 5-year locoregional disease-free survival (LRDFS) was 97.3% for the CBT patients was and 98.0% for the M...
Source: Indian Journal of Surgical Oncology - August 28, 2020 Category: Cancer & Oncology Source Type: research

An Unusual Soft Tissue Tumor of Uncertain Differentiation: a Case Report
(Source: Indian Journal of Surgical Oncology)
Source: Indian Journal of Surgical Oncology - August 28, 2020 Category: Cancer & Oncology Source Type: research

Pure Small Cell Neuroendocrine Carcinoma of Urinary Bladder: a Rare Entity
(Source: Indian Journal of Surgical Oncology)
Source: Indian Journal of Surgical Oncology - August 28, 2020 Category: Cancer & Oncology Source Type: research