Inflammatory Pseudotumour of Kidney: a Manifestation of IgG4 Disease
(Source: Indian Journal of Surgical Oncology)
Source: Indian Journal of Surgical Oncology - July 13, 2020 Category: Cancer & Oncology Source Type: research

Outcome of TRUS Biopsy with Limited Cores in Patients with PSA More Than 50  ng/dL: Can We Reduce the Number of Cores Without Affecting Outcomes?
AbstractThe aims of our study were to see outcomes of limited core biopsy and compare its outcomes with standard 12-core biopsy in patients with PSA more than 50  ng/dL. We did a retrospective analysis of 149 patients undergoing prostatic biopsy with PSA more than 50 ng/dL between January 2014 and December 2018. Out of 149 patients, 49 underwent limited core (2 to 6 cores) TRUS biopsy with no systemic 12-core biopsy. Other 100 patients underwent standard 1 2-core biopsy under TRUS guidance. Total of 149 patient’s records were analyzed and were included in the final analysis. There was no significant differe...
Source: Indian Journal of Surgical Oncology - July 13, 2020 Category: Cancer & Oncology Source Type: research

Testicular Surveillance Post-Orchidopexy and its Impact on Early Diagnosis of Testicular Cancer
AbstractPaediatric surgeons are expected to counsel patients about the potential risk of cancer post-orchidopexy and the need to self-examine in adulthood. The study objectives were to examine if such advice is being given and identify the stage of cancer at presentation in adult patients with history of orchidopexy. This was a 5-year observational, retrospective collaborative study between a tertiary paediatric surgical unit and its regional adult testicular cancer service, examining the nature of counselling given by paediatric surgeons to orchidopexy patients and their carers and estimating the local incidence of testic...
Source: Indian Journal of Surgical Oncology - July 12, 2020 Category: Cancer & Oncology Source Type: research

Patterns of Failure After Trimodal Treatment in Esophageal Squamous Cell Carcinoma: Initial Experiences from a High-Risk Endemic Area
We report patterns of failure in our patients of esophageal squamous cell cancer (ESCC) treated with trimodal approach. This is a single-institution retrospective analysis of 46 patients of locally advanced ESCC (treated between 2013 and 2017) managed by trimodal treatment approach. Variables were summarized using descriptive statistics. Survival statistics were estimated using Kaplan-Meier method. With a median follow-up of about 28  months, we noted an overall recurrence rate of 37% (17/46), with most of the failures being distant, with or without locoregional recurrence (4 isolated distant and 6 combined distant an...
Source: Indian Journal of Surgical Oncology - July 12, 2020 Category: Cancer & Oncology Source Type: research

A Rare Intramuscular Tumor in Gracilis Muscle: Granular Cell Tumor
(Source: Indian Journal of Surgical Oncology)
Source: Indian Journal of Surgical Oncology - July 12, 2020 Category: Cancer & Oncology Source Type: research

Analysis of SET and MYND Domain-Containing Protein 3 (SMYD3) Expression in Gallbladder Cancer: a Pilot Study
AbstractThe Suvar, Enhancer of zeste, and Trithorax (SET) and myeloid-Nervy-DEAF-1 (MYND) domain-containing protein 3 (SMYD3) is a histone lysine methyltransferase and has been recently unveiled to play significant roles in the progression of human cancer via regulating various key cancer-associated genes and pathways. The role of SMYD3 in gallbladder cancer (GBC) still needs to be studied. In the present study, we examined the SMYD3 gene expression at mRNA and protein level to look its impact on risk for developing gallbladder carcinogenesis. SMYD3 expression was evaluated by immunohistochemistry and reverse transcriptase...
Source: Indian Journal of Surgical Oncology - July 11, 2020 Category: Cancer & Oncology Source Type: research

Comparative Evaluation of the Short-Term Treatment Outcomes Between Open, Laparoscopic- and Robotic-Assisted Surgical Approaches for Rectal Cancer Treatment
This study aims to analyse the surgical results in terms of completion of TME, short-term surgical outcomes and hospital stay in after open, laparoscopic- and robotic-assisted rectal resections respectively. A retrospective review of prospectively maintained database of patients operated for carcinoma rectum between January 2013 and August 2018 at Manipal Comprehensive Cancer Centre, Manipal-Vattikuti Institute of Robotic Surgery, Bangalore, was analysed in this study. The surgical parameters like completion of total mesorectal excision; proximal, distal and circumferential resection margins; number of nodes retrieved; and...
Source: Indian Journal of Surgical Oncology - July 10, 2020 Category: Cancer & Oncology Source Type: research

An Unusual Metastasis from a Rare Histology at an Atypical Location-Isolated Metachronous Scapular Metastasis from Laryngeal Adenoid Cystic Carcinoma —a Case Report
(Source: Indian Journal of Surgical Oncology)
Source: Indian Journal of Surgical Oncology - July 10, 2020 Category: Cancer & Oncology Source Type: research

Atypical Presentation of Retroperitoneal Sarcomas as Hernias of the Inguinal Canal
(Source: Indian Journal of Surgical Oncology)
Source: Indian Journal of Surgical Oncology - July 9, 2020 Category: Cancer & Oncology Source Type: research

Are Ovarian Dermoid Cysts Should Be Always Considered Benign? A Case Series Study of Different Malignant Transformation
(Source: Indian Journal of Surgical Oncology)
Source: Indian Journal of Surgical Oncology - July 4, 2020 Category: Cancer & Oncology Source Type: research

Neobladder Perforation Post Blunt Trauma Abdomen: a Case Report
(Source: Indian Journal of Surgical Oncology)
Source: Indian Journal of Surgical Oncology - July 3, 2020 Category: Cancer & Oncology Source Type: research

Benign Mimickers of Urinary Bladder Cancer: a Case Series
We present an amalgamation of five cases having a high suspicion of urothelial malignancy, which were subsequently diagnosed as benign entities with better prognosis and thus warranted a different therapeutic approach. (Source: Indian Journal of Surgical Oncology)
Source: Indian Journal of Surgical Oncology - July 2, 2020 Category: Cancer & Oncology Source Type: research

Locoregional Flaps in Oncoreconstruction at a Tertiary Cancer Centre in North East India: a Review Through a Plastic Surgeon ’s Eye
AbstractLocal flaps are important parts of oncoreconstruction. The idea of writing this article is to give knowledge to my fellow aspiring plastic surgeons about the common locoregional flaps that are essentially done in a tertiary cancer centre. This is a retrospective study carried out in the Department of Plastic Surgery, Dr. B Borooah Cancer Institute, Guwahati, from May 2018 to April 2019. Musculoskeletal and soft tissue, head and neck and thorax and gynaecological malignancies which required locoregional flaps for reconstruction were taken up for the study. Flap reconstructions performed by oncosurgeons are not inclu...
Source: Indian Journal of Surgical Oncology - July 1, 2020 Category: Cancer & Oncology Source Type: research

Primary Leiomyosarcoma of the Calvarium with Intracranial Extension: a Case Report
(Source: Indian Journal of Surgical Oncology)
Source: Indian Journal of Surgical Oncology - July 1, 2020 Category: Cancer & Oncology Source Type: research

Tubulocystic Renal Cell Carcinoma in Young Adult
AbstractTubulocystic renal cell carcinoma is a uncommon neoplasm with unique pathological features and indolent clinical behaviour. We are reporting a case of tubulocystic renal cell carcinoma in young adult managed by partial nephrectomy. (Source: Indian Journal of Surgical Oncology)
Source: Indian Journal of Surgical Oncology - June 27, 2020 Category: Cancer & Oncology Source Type: research

Multiple Intracranial Lesions in Brain-Differential Diagnosis in a Lady of Reproductive Age: Case Report and Review of Literature
(Source: Indian Journal of Surgical Oncology)
Source: Indian Journal of Surgical Oncology - June 26, 2020 Category: Cancer & Oncology Source Type: research

Pancreaticopleural Fistula After Cytoreductive Surgery and HIPEC for Pseudomyxoma Peritonei —a Rare Presentation and Rare Complication
(Source: Indian Journal of Surgical Oncology)
Source: Indian Journal of Surgical Oncology - June 26, 2020 Category: Cancer & Oncology Source Type: research

A Prospective Study on Level of Concordance Between Core Needle Biopsy and Surgical Specimen for Assessing Oestrogen Receptor, Progesterone Receptor, and Her2/Neu Receptor Status in Carcinoma Breast and Its Implications on Treatment Decisions
AbstractA prospective study on the level of concordance between core needle biopsy specimen (CNB) and surgical specimen (SS) assesses the oestrogen receptor (ER), progesterone receptor (PR) and Her2/Neu receptor status in Carcinoma breast and its implications on treatment decisions. Ninety consecutive treatment naive operable breast cancer patients treated between September 2015 and April 2017 were included in our prospective study. All patients underwent core needle biopsy prior to definitive surgery. Immunohistochemistry (IHC) studies for ER, PR, and Her2/Neu receptor assay were done in both the CNB specimen and SS. The ...
Source: Indian Journal of Surgical Oncology - June 25, 2020 Category: Cancer & Oncology Source Type: research

Teratoma of Hepatoduodenal Ligament in Infancy: Precarious Location Posing a Grave Surgical Challenge
(Source: Indian Journal of Surgical Oncology)
Source: Indian Journal of Surgical Oncology - June 25, 2020 Category: Cancer & Oncology Source Type: research

Paraneoplastic Transaminitis —a Rare Manifestation of Ovarian Cancer
(Source: Indian Journal of Surgical Oncology)
Source: Indian Journal of Surgical Oncology - June 25, 2020 Category: Cancer & Oncology Source Type: research

Demographic Profile of Gastric Cancer in Afghanistan
AbstractGastric cancer is the second commonest cause of death among all cancers and the fifth most common cancer in the world. The number of deaths due to gastric cancer is about 723,000 annually. It is more common in men compared to women. The incidence of gastric cancer has 20-fold variation worldwide. In Asia, it is the third most prevalent cancer after breast and colorectal cancers. The prevalence of gastric cancer in Middle East varies from very high in Iran to low in Israel and very low in Egypt. The purpose of this study was to assess the demographic profile of gastric cancer in Afghanistan. A retrospective analysis...
Source: Indian Journal of Surgical Oncology - June 25, 2020 Category: Cancer & Oncology Source Type: research

Rosettes —Diagnostic Feature of Askin Tumor on Cytology
We report a case of an Askin tumor in an adult patient, diagnosed on fine-needle aspiration cytology. Clinico-radiological findings, immunochemistry, and cytogenetics help in confirming the diagno sis. (Source: Indian Journal of Surgical Oncology)
Source: Indian Journal of Surgical Oncology - June 24, 2020 Category: Cancer & Oncology Source Type: research

Collision Tumor at Cerebellopontine Angle in a Patient Without Neurofibromatosis Type 2
(Source: Indian Journal of Surgical Oncology)
Source: Indian Journal of Surgical Oncology - June 24, 2020 Category: Cancer & Oncology Source Type: research

Local Protocol for Management of Low-Grade Appendiceal Mucinous Neoplasm (LAMN)
This study was aiming to provide a local protocol for our trust for such cases. From prospectively maintained database, patients who underwent appendicectomy between 2011 and 2017 were identified. Those with histological confirmation of LAMN were included. Retrospective analysis of operative notes, investigations and follow-up, return to theatres or development of pseudomyxoma peritonei (PMP) was performed. Four thousand six hundred twenty-eight patients had appendicectomy; 36 were diagnosed with LAMN. Age range was 30 –88 (20 females). Fifteen had their operation as emergency and 13 elective, either for abnormal-loo...
Source: Indian Journal of Surgical Oncology - June 23, 2020 Category: Cancer & Oncology Source Type: research

Diagnostic Accuracy of Cervical Pap Smear and Colposcopy in Detecting Premalignant and Malignant Lesions of Cervix
The objective of this study was to determine the diagnostic accuracy of pap smear and colposcopy in detecting the premalignant and malignant lesion of the cervix. In this cross-sectional study, a total number of 160 women who presented with abnormal clinical problem or routine checkup during a 6-month period were included. All the patients underwent pap smear and colposcopy by the same gynecologists team, and finally, cervical biopsy was performed in all the individuals. The demographic and clinical characteristics as well as the obstetrics history were recorded. The diagnostic accuracy of each test was calculated accordin...
Source: Indian Journal of Surgical Oncology - June 23, 2020 Category: Cancer & Oncology Source Type: research

Case Report: a Case of Jejunal Mesenteric Teratoma in Adult Male: a Rare Case
(Source: Indian Journal of Surgical Oncology)
Source: Indian Journal of Surgical Oncology - June 22, 2020 Category: Cancer & Oncology Source Type: research

Radiation-Induced Vasculopathy Precipitating Penile Gangrene
(Source: Indian Journal of Surgical Oncology)
Source: Indian Journal of Surgical Oncology - June 20, 2020 Category: Cancer & Oncology Source Type: research

Perivascular Epithelioid Cell Tumour of the Uterus: a Case Report
(Source: Indian Journal of Surgical Oncology)
Source: Indian Journal of Surgical Oncology - June 20, 2020 Category: Cancer & Oncology Source Type: research

Tracheal Resection and Reconstruction for Malignant Tumor
(Source: Indian Journal of Surgical Oncology)
Source: Indian Journal of Surgical Oncology - June 20, 2020 Category: Cancer & Oncology Source Type: research

Evolution of Robotic Surgery in a Colorectal Cancer Unit in India
AbstractOnly a handful of institutions in the country have an established robotic surgery program. Evolution of robotic surgery in the colorectal division, from inception to recent times, is presented here. All the patients undergoing robotic colorectal surgery from the inception of the program (September 2014) to August 2019 were identified. The patient and treatment details and short-term outcomes were collected retrospectively from the prospectively maintained database. The cohort was divided into four chronological groups (group 1 being the oldest) to assess the surgical trends. There were 202 patients. Seventy-one per...
Source: Indian Journal of Surgical Oncology - June 18, 2020 Category: Cancer & Oncology Source Type: research

Pedicled Latissimus Dorsi Myocutaneous Flap-an Effective Reconstructive Option for Extensive Buccal Cancer Resection in Resource Constrained and Salvage Settings
AbstractFree flaps are the gold standard for reconstruction of extensive buccal cancer resections. However, salvage surgeries in previously operated and radiated necks, cost, increased operating time, and patient co-morbidities limit their routine use in high volume and resource-constrained settings. Pectoralis major myocutaneous (PMMC) flap is the mainstay of reconstruction of large buccal defects. However, reconstruction becomes a challenge during salvage of recurrences where PMMC has been utilized in previous reconstruction and in female patients where PMMC harvest results in major donor site morbidity. A retrospective ...
Source: Indian Journal of Surgical Oncology - June 17, 2020 Category: Cancer & Oncology Source Type: research

Operative Challenges with Minimally Invasive McKeown Esophagostomy with Two-Field Lymphadenectomy in a Case of Situs Inversus Totalis with Carcinoma Esophagus: A Case Report with Review of the Literature
We describe a case of a 50-year-old gentleman with locally advanced lower esophagus carcinoma post-neoadjuvant chemoradiotherapy with situs inversus totalis and treated with minimally invasive McKeown esophagectomy using a left thoracoscopic, laparoscopic-assisted and right cervical approach. The operative procedure and difficulties during surgery are highlighted. Minimal invasive esophagectomy is safe and feasible in situs inversus totalis. Recognition of the anatomy with a meticulous preoperative planning is advocated for an uneventful operative intervention. (Source: Indian Journal of Surgical Oncology)
Source: Indian Journal of Surgical Oncology - June 16, 2020 Category: Cancer & Oncology Source Type: research

Factors Predisposing to the Unplanned Hospital Readmission (UHR) in Patients Undergoing Surgery for Oral Cavity Squamous Cell Carcinoma (OSCC): Experience from a Tertiary Cancer Centre
The objective of the study was to identify the UHR rates of oral cavity squamous cell carcinoma (OSCC) patients following surgery and identify the predisposing factors for UHR. We conducted this retrospective analysis of all patients who underwent surgery for OSCC in our (single) surgical unit from January 2016 to December 2018. A total of 804 patients satisfied the eligibility criteria. Majority of the patients were males (n = 650, 80.8%). The median age of the patients was 50 years (Range: 16–89 years). The most common oral cavity subsite was buccal mucosa gingivobuccal (BM-GBS) OSCC. Forty ...
Source: Indian Journal of Surgical Oncology - June 15, 2020 Category: Cancer & Oncology Source Type: research

Role of Hyperbaric Medicine for Osteoradionecrosis and Post Irradiation Wounds: an Institutional Experience
This study was carried out in the Plastic Surgery Department, from November 2011 to December 2018. A total of 30 patients with post irradiation patients subjected to hyperbaric oxygen therapy during the management were enrolled in the study. The results regarding the changes in wound and complications were noted. Out of 30 patients, 20 patients were with radiation injury involving the oral cavity, one patient with left lower limb, one with breast, 3 with radiation injury of cheek, 3 of mandible, one with radiation cystitis and one involving the tooth socket. One patient experienced reversible myopia as a complication of hy...
Source: Indian Journal of Surgical Oncology - June 15, 2020 Category: Cancer & Oncology Source Type: research

Marginal Mandibulectomy Defect Reconstruction with Pectoralis Major Myocutaneous (PMMC) Flap in Cases of Carcinoma Buccal Mucosa: Experience from a Tertiary Cancer Institute
AbstractPatients with carcinoma buccal mucosa requiring marginal mandibulectomy pose various key challenges with regard to reconstruction. To study the role and feasibility of the PMMC flap reconstruction in patients of carcinoma buccal mucosa with intact mandible. Study design: retrospective analysis of prospectively maintained data at a tertiary cancer institute in India. Inclusion criteria: all patients of carcinoma buccal mucosa undergoing marginal mandibulectomy at our institute from 1st Jan 2015 to 31st March 2018 with reconstruction done by the PMMC flap. The retrospective analysis showed 82 patients satisfied the i...
Source: Indian Journal of Surgical Oncology - June 14, 2020 Category: Cancer & Oncology Source Type: research

Corona – Covid -19 – Pandemic Are we in the Right Direction
(Source: Indian Journal of Surgical Oncology)
Source: Indian Journal of Surgical Oncology - June 13, 2020 Category: Cancer & Oncology Source Type: research

Clinical and Radiological Profile of Ten Interesting Though Rare Presentations of Giant Cell Tumor of Bone
This study aims to find out the clinical and radiological profile of ten rare presentations of GCT. We have conducted a retrospective analysis of medical records of ten interesting presentations of giant cell tumor of bone. There was a patient with soft-tissue recurrence after excision. In five cases, the GCT occurred at rare sites and a case to discuss the radiological dilemma in the diagnosis. One case of pathological fracture, another case of seeding of tumor cells in the graft donor site, and a case of pulmonary metastasis were included. There were seven females, two males, and a boy. Out of ten patients, all except tw...
Source: Indian Journal of Surgical Oncology - June 13, 2020 Category: Cancer & Oncology Source Type: research

The Association of Human Papillomavirus in Benign and Malignant Laryngeal Lesions —a Pilot Study
AbstractVarious etiological factors have been described in laryngeal carcinogenesis. Tobacco and alcohol play a major role in the development of laryngeal cancers. However, recently there has been an overshadowing of association of human papillomavirus infection in laryngeal cancers. The aim of this study is to assess the prevalence of human papillomavirus (HPV) in malignant laryngeal lesions. This is a case control study. We conducted this study using tumor tissue specimens from 30 laryngeal squamous cell carcinoma patients and benign laryngeal tissue specimens from 30 cancer-free controls. The specimens from the lesion w...
Source: Indian Journal of Surgical Oncology - June 13, 2020 Category: Cancer & Oncology Source Type: research

Mucinous Cystic Neoplasm of the Liver and Extrahepatic Biliary Tract with Ascending Cholangitis: a Case Report and Review of the Literature
We present a 31-year-old female patient who presented with complaints of pain abdomen, vomiting, fever, and obstructive jaundice. Ultrasound abdomen showed features suggestive of cholangitic abscess. Computed tomography abdomen showed features suggestive of cholangitic abscess and abrupt termination of the proximal CBD secondary to the stricture. A left hemi-hepatectomy was performed which showed a multiloculated cystic liver lesion with the involvement of extrahepatic duct, cystic duct, and proximal common bile duct. Histopathology showed cyst was lined by mucin secreting columnar epithelium without nuclear atypia, the wa...
Source: Indian Journal of Surgical Oncology - June 12, 2020 Category: Cancer & Oncology Source Type: research

Outcomes of Minimally Invasive Radical Prostatectomy –a Contemporary Review
AbstractProstatectomy has been widely accepted as a treatment option for prostate cancer and can be performed via an open, laparoscopic, and robotic approach. The outcomes following prostatectomy are primarily sub-grouped into oncological and functional outcomes. Oncological outcomes have been comparable in the above three surgical modalities. However, the robotic platform seems to have a better functional outcome compared to open prostatectomy. The data on the outcome of the laparoscopic approach is scarce and is not widely performed due to technical difficulty. With experience continence outcomes have reached a plateau i...
Source: Indian Journal of Surgical Oncology - June 11, 2020 Category: Cancer & Oncology Source Type: research

Hypercalcemia of Malignancy: Time to Pull the Brakes
AbstractHypercalcemia of malignancy (HOM) is usually seen in advanced stage and carries a poor prognosis. Survival outcomes are dismal and most of the patients are unable to receive subsequent definite anti-cancer therapy. There is lack of any retrospective or prospective data regarding hypercalcemia of malignancy in Indian population. We aim to describe survival outcomes in hypercalcemia associated with solid organ malignancies. Forty-five patients diagnosed with HOM associated with solid organ malignancies were included in the study. Patients were followed up till death. Clinical features and survival outcomes were noted...
Source: Indian Journal of Surgical Oncology - June 11, 2020 Category: Cancer & Oncology Source Type: research

Primary Malignant Melanoma of Anorectum CT Findings: a Single Tertiary Center ’s Experience
In conclusion, primary anorectal malignant melanoma is a rare, highly aggressive tumor and should be considered in patients with a bulky intraluminal polypoid mass that does not cause colonic obstruction in the anorectal region with large-sized lymphadenopathy. (Source: Indian Journal of Surgical Oncology)
Source: Indian Journal of Surgical Oncology - June 11, 2020 Category: Cancer & Oncology Source Type: research

Was it Ewing ’s? A Diagnostic and Therapeutic Dilemma
We present an atypical case of histopathology suggesting hemangioendothelioma and immunohistochemistry-proven Ewing ’s sarcoma in a 39-year-old lady who presented with multiple stony hard swellings involving the occipital region of the scalp, right cervical lymph node, right scapular region, left infraclavicular region of the chest, right anterior abdominal wall swelling, and inner aspect of right thigh. She un derwent left-sided below-knee amputation for parosteal osteosarcoma in the left distal tibia 3 years back. Palliative radiotherapy with dose of 30 Gy in 10 fractions over 2 weeks was administered to the r...
Source: Indian Journal of Surgical Oncology - June 11, 2020 Category: Cancer & Oncology Source Type: research

Synchronous Primary Diffuse Large B Cell Lymphoma and Adenocarcinoma of the Stomach: a Clinical Dilemma
AbstractA 65-year-old Caucasian man was admitted to our department with progressive weakness, dyspepsia, and weight loss. Endoscopic biopsies revealed a gastric diffuse large B cell lymphoma. Computed tomography scan showed a locally advanced bulky gastric tumor with peritoneal involvement. Laparoscopic staging was performed and biopsies showed peritoneal localization of adenocarcinoma. A new endoscopy with multiple mapping biopsies confirmed the diagnosis of diffuse large B cell lymphoma. A multidisciplinary team evaluated the stage of both tumors and the patient started on a chemotherapy regimen with cisplatin, 5-fluorou...
Source: Indian Journal of Surgical Oncology - June 10, 2020 Category: Cancer & Oncology Source Type: research

AJCC 8th Versus AJCC 7th as a Prognostic Indicator in Buccal Mucosal Squamous Cell Carcinoma
This study is to focus on a single subsite of oral cavity which is known for its poor prognosis. We evaluated 109 patients who had buccal mucosal squamous cell carcinomas (BSCC) who underwent treatment, with a curative intend, between 2014 and 2015. Clinical records were reviewed and the tumors were re-staged as per 8th edition of AJCC; disease-free survival (DFS) was also analyzed. Our study population had a mean age of 54.5  ± 10.35 years and male to female ratio of 4:1. During a median follow-up of 41 months, 35 patients (32.1%) developed recurrence. There was a statistically significant s...
Source: Indian Journal of Surgical Oncology - June 10, 2020 Category: Cancer & Oncology Source Type: research

Large Adrenal Lesion Series in a Tertiary Care Center in Northern India: Diagnostic and Operative Challenges
AbstractLarge adrenal tumors pose varied challenges to surgeons in terms of diagnosis, planning surgical approach, and also intra-operative difficulties in resection. The aim of this study is to discuss challenges in the management of large and difficult adrenal lesions. A retrospective analysis was done on data of all patients with large adrenal lesions/paragangliomas managed from 1 June 2016 to 30 August 2018. Forty-eight patients with adrenal lesions underwent treatment in 2  years duration. Pain in the abdomen was the most common presentation. Mean age was 34.4 years (range 2–60), female to male (23:25)...
Source: Indian Journal of Surgical Oncology - June 9, 2020 Category: Cancer & Oncology Source Type: research

Adenoid Cystic Carcinoma Breast: a Rare Entity
(Source: Indian Journal of Surgical Oncology)
Source: Indian Journal of Surgical Oncology - June 9, 2020 Category: Cancer & Oncology Source Type: research

Robotic Surgery for Rectal Cancer: Hype or Hope? (Indian Experience)
AbstractThe primary goal to achieve cure in oncology is to reduce recurrence, maximize disease-free survival, maintain function, and optimize quality of life. Surgery remains the mainstay treatment modality in rectal cancer. The current trend is to perform least invasive method of doing complex surgeries while not compromising in the oncological of functional outcomes of patients. Total mesorectal excision (TME) for rectal cancer surgery entails removal of the rectum with its fascia as an intact unit while preserving surrounding vital structures. The procedure is technically challenging because of the narrow and deep pelvi...
Source: Indian Journal of Surgical Oncology - June 8, 2020 Category: Cancer & Oncology Source Type: research

Dual Cancer: Papillary and Signet Ring Cell Carcinoma, Arising in a Patient Operated for Choledochal Cyst: an Unusual Histological Finding
(Source: Indian Journal of Surgical Oncology)
Source: Indian Journal of Surgical Oncology - June 6, 2020 Category: Cancer & Oncology Source Type: research

microRNAs: New-Age Panacea in Cancer Therapeutics
AbstractMicroRNAs (miRNAs) are small (~  18–25 nucleotides in length), endogenous, non-coding RNAs, which regulate gene expression. Numerous studies have demonstrated the dysregulation of miRNA expression in human cancers through various mechanisms, which include genetic alteration of miRNA genes, abnormal transcriptional control of m iRNAs, anomalous epigenetic changes, and defective miRNA biogenesis machinery. They may function as either oncomiRs or tumor suppressor miRNAs in a tissue or cell-specific manner. The dysregulated miRNAs are known to affect the hallmarks of cancer, and some of these miRNAs have s...
Source: Indian Journal of Surgical Oncology - June 6, 2020 Category: Cancer & Oncology Source Type: research