High-Grade Endometrial Cancer —Behaviour and Outcomes at a Tertiary Cancer Centre
AbstractHigh-grade endometrial carcinomas are a heterogeneous group of clinically aggressive tumours. They include FIGO grade 3 endometrioid adenocarcinoma, uterine papillary serous carcinoma (UPSC), clear cell carcinoma, undifferentiated carcinoma and carcinosarcomas or malignant mixed Mullerian tumour (MMMT). The aim of this study is to look at clinicopathological features and survival outcomes of high-grade endometrial cancers of the uterus in our centre. A tertiary care centre in India. The study design is retrospective with survival analysis. We did a retrospective analysis of all patients admitted with a diagnosis of...
Source: Indian Journal of Surgical Oncology - August 21, 2019 Category: Cancer & Oncology Source Type: research

Etiologic Role of Kinases in the Progression of Human Cancers and Its Targeting Strategies
AbstractCancer is one of the dominant causes of death worldwide while lifelong prognosis is still inauspicious. The maturation of the cancer is seen as a process of transformation of a healthy cell into a tumor-sensitive cell, which is held entirely at the cellular, molecular, and genetic levels of the organism. Tyrosine kinases can play a major, etiologic role in the inception of malignancy and devote to the uncontrolled proliferation of cancerous cells and the progression of a tumor as well as the development of metastatic disease. Angiogenesis and oncogene activation are the major event in cell proliferation. The growth...
Source: Indian Journal of Surgical Oncology - August 19, 2019 Category: Cancer & Oncology Source Type: research

Pleomorphic Liposarcoma of Finger –a Rare Entity
(Source: Indian Journal of Surgical Oncology)
Source: Indian Journal of Surgical Oncology - August 19, 2019 Category: Cancer & Oncology Source Type: research

Reliable Option for Circumferential Pharyngeal Reconstruction with Deltopectoral Flap: a Case Report
(Source: Indian Journal of Surgical Oncology)
Source: Indian Journal of Surgical Oncology - August 17, 2019 Category: Cancer & Oncology Source Type: research

Awareness of Lymphatic Anatomy to Decrease False Negative Sentinel Lymph Node Rate in Breast Cancer
(Source: Indian Journal of Surgical Oncology)
Source: Indian Journal of Surgical Oncology - August 17, 2019 Category: Cancer & Oncology Source Type: research

Management of Giant Seminoma in an Undescended Testis: a Case Report
(Source: Indian Journal of Surgical Oncology)
Source: Indian Journal of Surgical Oncology - August 17, 2019 Category: Cancer & Oncology Source Type: research

Role of Pelvic Lymphadenectomy in Intermediate-Risk Endometrial Cancer and Predictors of Nodal Positivity in Indian Patients
AbstractOne of the most intense controversies in endometrial cancer revolves around the need for lymphadenectomy at the time staging. The study carried out to analyze the role of staging with pelvic lymphadenectomy in intermediate-risk stage I endometrial cancer —stage IA grade III and stage IB grades I and II. Review analysis of all the patients with stage I carcinoma endometrium intermediate risk treated at our institution between January 2006 and December 2014. All demographic data, tumor factors, adjuvant treatment, follow-up, and recurrence were reco rded. Sixty-five were in intermediate-risk group, of which 21 ...
Source: Indian Journal of Surgical Oncology - August 16, 2019 Category: Cancer & Oncology Source Type: research

Correlation of Specimen/Breast Volume Ratio to Cosmetic Outcome After Breast Conserving Surgery
AbstractBreast conserving surgery (BCS) is currently the standard of care for early breast cancer. One of the key determinants for the line of treatment in breast cancer is the size of the tumor in relation to the breast size. The aim of this study is to determine the effect of the ratio of the excised specimen to breast volume on the cosmetic outcome after conventional BCS. This is a retrospective study conducted on female patients with early stage breast cancer who underwent BCT at National Cancer Institute, Cairo University. The study included 41 patients with stage I and II breast cancer. Breast volume was calculated u...
Source: Indian Journal of Surgical Oncology - August 16, 2019 Category: Cancer & Oncology Source Type: research

Primary Ewing ’s Sarcoma/Primitive Neuroectodermal Tumour of the Cervix: a Rare Tumour
(Source: Indian Journal of Surgical Oncology)
Source: Indian Journal of Surgical Oncology - August 16, 2019 Category: Cancer & Oncology Source Type: research

Association of Papillary Thyroid Carcinoma with GIST —a Case Series
AbstractGastrointestinal stromal tumours (GIST) are the most common gastrointestinal mesenchymal tumours of the gastrointestinal tract. They are diagnosed by the expression of markers like CD 117, CD 34, DOG-1 and PDGFRA. The identification of these mutations has resulted in a better understanding of their oncogenic mechanisms. Few studies have shown the high incidence of a second malignancy including papillary thyroid cancer (PTC) in known patients of GIST. Literature review on pathogenesis of GIST and PTC showed that PTC targeting Protein Kinase C theta (PKC θ) plays role in both PTC and GIST. Further studies have ...
Source: Indian Journal of Surgical Oncology - August 14, 2019 Category: Cancer & Oncology Source Type: research

A Study of Clinical Presentation and Management of Malignant Gastric Outlet Obstruction (Northeast India –Based Single-Centre Experience)
AbstractGastric outlet obstruction (GOO) occurs when there is mechanical obstruction impending gastric emptying. GOO has both benign and malignant aetiologies. In this paper we want to discuss, clinical presentation and management of malignant GOO. This is a retrospective observational study of 5  years in patients presenting with malignant GOO. Study was conducted in Dr. B. Borooah Cancer Institute, Guwahati, India. Patients with malignant GOO who were operated were included in this study. Chi-square test was used to evaluate association between categorical values. Independentt test and one-way ANOVA (analysis of var...
Source: Indian Journal of Surgical Oncology - August 13, 2019 Category: Cancer & Oncology Source Type: research

Modified Reinforced Staple Closure Technique Decreases Postoperative Pancreatic Fistula After Distal Pancreatectomy
AbstractPostoperative pancreatic fistula (POPF) is a serious complication that can occur following distal pancreatectomy (DP). Recent studies demonstrated that the use of reinforced staplers with bioabsorbable mesh significantly reduced the incidence of POPF, although the safety and efficacy of this approach remain controversial. Therefore, we originally developed a modified closure technique that combines the use of a reinforced stapler with bioabsorbable mesh with suture closure of the main pancreatic duct. The aim of this study was to determine whether our closure technique is predictive of POPF after DP. Fifty-nine con...
Source: Indian Journal of Surgical Oncology - August 13, 2019 Category: Cancer & Oncology Source Type: research

Paraneoplastic Syndrome Associated with the Retroperitoneal Dedifferentiated Liposarcoma: an Atypical Presentation and Review of the Literature
AbstractRetroperitoneal liposarcoma is usually asymptomatic until it is large enough to compress the surrounding organs. Here, we report a rare atypical case of primary retroperitoneal dedifferentiated liposarcoma who presented primarily with the misguiding and challenging paraneoplastic symptoms of high-grade fever and thrombocytosis instead of demonstrating the usual compressive symptoms. Such an extremely rare clinical presentation may mislead the diagnostic and treatment approach towards the search for medical causes, without a hint, that the tumor itself is causing these symptoms. Complete tumor excision usually leads...
Source: Indian Journal of Surgical Oncology - August 13, 2019 Category: Cancer & Oncology Source Type: research

Occult Multiple Mediastinal Lymph Node Metastasis and Malignant Pleural Effusion Due to Signet Ring Cell Gastric Cancer
(Source: Indian Journal of Surgical Oncology)
Source: Indian Journal of Surgical Oncology - August 13, 2019 Category: Cancer & Oncology Source Type: research

Does Quality of Life Among Modified Radical Mastectomy and Breast Conservation Surgery Patients Differ? A 5-Year Comparative Study
AbstractBreast cancer is the most common cancer among females worldwide, of whom more than 80% survive for more than 5  years. Hence, ensuring a good quality of life (QOL) is essential to achieve holistic approach in treating patients. A cross-sectional study was conducted to compare the QOL in women who underwent modified radical mastectomy (MRM) and breast conservation surgery (BCS) for breast cancer in the last 5 years. QOL was evaluated based on the long-term quality of life–breast cancer (LTQOL–BC) questionnaire. A greater percentage of women who underwent MRM complained of difficulty in completi...
Source: Indian Journal of Surgical Oncology - August 13, 2019 Category: Cancer & Oncology Source Type: research

Sentinel Lymph Node Biopsy in Colon Cancer: an Institutional Experience
AbstractLymph node staging is a major prognostic factor in colorectal cancer and remains to be the most important criterion for selecting patients for adjuvant therapy. The standard approach for lymph node evaluation is based on manual dissection and histological evaluation of HE-stained slides. For stage III disease (node positive), adjuvant chemotherapy increases the survival rate, while in node-negative stage II disease, in most cases, the chemotherapy is contraindicated due to increased morbidity without real benefit. Up to 30% of patients with node-negative colon cancer staged by standard pathologic techniques ultimat...
Source: Indian Journal of Surgical Oncology - August 13, 2019 Category: Cancer & Oncology Source Type: research

Cutaneous Acral Metastasis from Renal Cell Carcinoma —a Case Report
We report a case of 63-year-old male, with renal clear cell carcinoma with lung metastasis who had cutaneo us metastasis to the fingertip which was confirmed by histopathological examination. Apart from its rarity, this clinical case adds another site of renal cell carcinoma metastasis to the present literature. The skin metastasis represents a widely disseminated state of the disease with a very guarded prognosis and limited life span after its diagnosis. (Source: Indian Journal of Surgical Oncology)
Source: Indian Journal of Surgical Oncology - August 13, 2019 Category: Cancer & Oncology Source Type: research

Oncoplastic Breast Reconstruction in Conservation Surgery: Steps to Follow for a Successful Work
(Source: Indian Journal of Surgical Oncology)
Source: Indian Journal of Surgical Oncology - August 13, 2019 Category: Cancer & Oncology Source Type: research

Methods of Treatment and Outcome for Ovarian Germ Cell Tumors
This study aims to assess the different clinico-pathological factors of ovarian germ cell tumors, treatment methods, and outcome. This is a retrospective observational cohort study including 54 cases with OGCTs which were studied from the period between January 2013 and December 2016. The study was performed at National Cancer Institute (NCI)–Cairo University, Egypt. All cases had cytoreductive surgery in the form of unilateral salpingo-oophorectomy in 42 cases and total abdominal hysterectomy in 12 case s. Complete cytoreduction was achieved in 46 cases while 8 cases had residual disease after surgery. Adjuvant chem...
Source: Indian Journal of Surgical Oncology - August 13, 2019 Category: Cancer & Oncology Source Type: research

Assessment of Masticatory Function in Oral Cancer Patients with Mandibulectomy Followed by Pectoralis Major Myocutaneous Flap Reconstruction
AbstractMandibular resections have a dramatic effect on oral cavity functions. Ablative surgical defects are complex which are better reconstructed with free flaps. In developing countries like India, where majority of patients come from low socioeconomic status, pectoralis major myocutaneous flap is the most preferred reconstructive option. A retrospective questionnaire study was carried out to assess the mastication in patients with mandibulectomy followed by pectoralis major myocutaneous flap reconstruction. At the end of the study, it was observed that 86.6% of the patients had a good performance despite the lack of bo...
Source: Indian Journal of Surgical Oncology - August 11, 2019 Category: Cancer & Oncology Source Type: research

Molecular Biology in the Breast Clinics —Current status and future perspectives
AbstractBreast cancer is no longer considered a single disease, and with better understanding of cancer biology, its management has evolved over the years, into a complex individualized use of therapeutics based on variable expressions of predictive and prognostic factors. With the advent of molecular and genetic research, the complexity and diversity of breast cancer cells and their ability to survive and develop resistance to treatment strategies became more evident. At the same time, targeted therapies evolved, as specific targets were discovered such as HER2 receptor, and androgen receptor. More recent is the developme...
Source: Indian Journal of Surgical Oncology - August 10, 2019 Category: Cancer & Oncology Source Type: research

Digital Breast Tomosynthesis as a Tool in Confirming Negative Surgical Margins in Non-palpable Breast Lesions
In this study, we have evaluated the accuracy of specimen mammogram (SM) with digital breast tomosynthesis (DBT) for margin assessment by comparing it to the excised margins as measured in final histopathology. This is a prospective observational study of patients with radiologically suspicious impalpable breast lesions. The patients underwent ultrasound-guided hook wire placement followed by excision of the lesion, subjected to digital tomosynthesis mammogram, and margins were revised on table when indicated. These findings were correlated with final histopathological margin. Our study included 30 patients and out of the ...
Source: Indian Journal of Surgical Oncology - July 30, 2019 Category: Cancer & Oncology Source Type: research

Extradigital Painful Glomus Tumour of Heel Pad
(Source: Indian Journal of Surgical Oncology)
Source: Indian Journal of Surgical Oncology - July 29, 2019 Category: Cancer & Oncology Source Type: research

Outcome of Nasolabial Flap in the Reconstruction of Head and Neck Defects
AbstractNasolabial flaps have been recognized as versatile flaps for a variety of defects in the face, nose, lip and the oral cavity and intraoral defects created after the excision of benign and malignant tumours. Nasolabial flaps have been utilized for covering small-to-medium size defects and usually require a second-stage procedure to divide the flap. To study the outcome of nasolabial flap in the reconstruction of head and neck defects. A prospective analysis of 25 cases was done. Of this, 24 cases were oral cancers, and one case was post-traumatic left ala loss. Oral cancers from stage I to IVa were treated with prim...
Source: Indian Journal of Surgical Oncology - July 17, 2019 Category: Cancer & Oncology Source Type: research

Extra-Uterine Low-Grade Endometrial Stromal Sarcoma Presenting as a Urinary Bladder Mass: a Case Report with Review of the Literature
(Source: Indian Journal of Surgical Oncology)
Source: Indian Journal of Surgical Oncology - July 15, 2019 Category: Cancer & Oncology Source Type: research

Clinicopathologic Determinants of Outcome in Pathologic T4a (pT4a) Squamous Cell Carcinoma of the Gingivobuccal Subsite of the Oral Cavity
In this study, we aimed to study the clinic-pathological factors which may influence treatment outcomes in pT4a patients. This is a retrospective study of 121 patients who underwent surgery for oral squamous cell carcinoma between August 2011 and December 2016, staged pT4a. Overall survival (OS) and disease-free survival (DFS) were analyzed for variables including age, depth of invasion, margin status, differentiation, nodal status, extranodal spread, lymphovascular and perineural spread, and adjuvant treatment. The study cohort comprised 93 males with mean age 60.28  years (S.D. 11.25). Median DFS was 21 months ...
Source: Indian Journal of Surgical Oncology - June 27, 2019 Category: Cancer & Oncology Source Type: research

Serratus Anterior Plane Block for Post-Thoracotomy Analgesia: a Novel Technique for the Surgeon and Anaesthetist
We report our experience with 10 thoracotomy cases where this block was used as a post-operative analgesic technique. Patients undergoing pulmonary metastasectomy or lobectomy received ultrasound-guided serratus anterior plane block between the serratus anterior and the external intercostal muscles with 0.25% ropivacaine, and a catheter was inserted. Post-operatively, 0.125% ropivacaine with fentanyl (1  mcg/ml) was given as infusion at 5–7 ml/h. Other analgesics were paracetamol and diclofenac. Fentanyl infusion at 0.25 mcg/kg/h was the rescue analgesic if pain persisted. Four out of 10 patients requi...
Source: Indian Journal of Surgical Oncology - June 21, 2019 Category: Cancer & Oncology Source Type: research

Troublesome Venous Bleeding During Wertheim ’s Hysterectomy: a Review of Surgical Anatomy and Point of Technique to Troubleshoot
(Source: Indian Journal of Surgical Oncology)
Source: Indian Journal of Surgical Oncology - June 15, 2019 Category: Cancer & Oncology Source Type: research

Elevated Neutrophil –Lymphocyte Ratio in Luminal-Type Locally Advanced Breast Cancer to Circumvent Neo-Adjuvant Chemotherapy
AbstractNeutrophil –Lymphocyte Ratio (NLR) provides an understanding of the systemic inflammatory conditions. NLR plays an important role as a predictor of mortality in breast and other malignancies. The application of NLR to predict prognosis of Locally Advanced Breast Cancer (LABC) has not been well developed. In this retrospective study, we establish a relationship of pre-treatment NLR with the Pathological Complete Response (pCR) in LABC patients to enhance decision-making and treatment protocols. Data of women diagnosed with carcinoma breast between January 2015 and December 2017 was retrieved from hospit al rec...
Source: Indian Journal of Surgical Oncology - June 15, 2019 Category: Cancer & Oncology Source Type: research

Editorial
(Source: Indian Journal of Surgical Oncology)
Source: Indian Journal of Surgical Oncology - June 15, 2019 Category: Cancer & Oncology Source Type: research

Efficacy and Safety of Lateral Approach-Video Endoscopic Inguinal Lymphadenectomy (L-VEIL) over Open Inguinal Block Dissection: a Retrospective Study
AbstractThis retrospective study compared the immediate post-operative short-term outcomes of Lateral Approach-Video Endoscopic Inguinal Lymphadenectomy (L-VEIL) and open surgery approach in patients with TNM stage N0 and N1 tumors. Inguinal lymphadenectomies performed for various TNM stage N0 and N1 cancers between January 2011 and December 2015 at a single center were analyzed by collecting data from operation theater records and case files. Mean blood loss, operative time, drain output, nodal yield, nodal positivity, and complications were analyzed as post-procedural outcomes. Among the 116 surgeries performed, 92 were ...
Source: Indian Journal of Surgical Oncology - June 14, 2019 Category: Cancer & Oncology Source Type: research

Robotic Surgery for Malignant Liver Disease: a Systematic Review of Oncological and Surgical Outcomes
AbstractRobot-assisted laparoscopic surgery is yet another modification of minimally invasive liver surgery. It is described as feasible and safe from the surgical point of view; however, oncological outcomes need to be adequately analysed to justify the use of this technique when resecting malignant liver tumours. We reviewed existing English medical literature on robot-assisted laparoscopic liver surgery. We analysed surgical outcomes and oncological outcomes. We analysed operative parameters including operative time, type of hepatectomy, blood loss, conversion rate, morbidity and mortality rates and length of stay. We a...
Source: Indian Journal of Surgical Oncology - June 13, 2019 Category: Cancer & Oncology Source Type: research

Primary Ovarian Carcinoma with Rectal Metastasis —a Rare Presentation (a Case Report)
AbstractRectal metastasis from primary ovarian cancer is a rare condition. In this case report, we present a case of 45-year-old female presented with chief complaint of pain abdomen and vomiting and with on and off history of per rectal bleeding. On examination, patient was pallor, hemoglobin level of 5.5 for which she was admitted. On per rectal examination, there was circumferential rectal growth around 7  cm from anal verge. Imaging was suggestive of ovarian lesion with rectal growth. Biopsy and immunohistochemistry of rectal growth was suggestive of metastatic well-differentiated papillary adenocarcinoma probably...
Source: Indian Journal of Surgical Oncology - June 5, 2019 Category: Cancer & Oncology Source Type: research

Rare Case Presentation of Leiomyosarcoma as IVC Thrombus
BackgroundLeiomyosarcoma (LMS) of vascular origin is uncommon. This leiomyosarcoma is seen occurring from the tunica media of major blood vessels. Leiomyosarcoma of venous origin is five times more common those of arterial origin. Most cases are presented in woman with a median age of 50  years [1]. We are presenting a case where histopathology was instrumental in making the diagnosis of LMS in the thrombus and confirmed by IHC.A 46-year old female presented with bilateral swelling of lower limbs and distention of abdomen. Her CT, MRI, and color Doppler were suggestive of IVC, hepatic, and renal vein thrombosis. Histo...
Source: Indian Journal of Surgical Oncology - June 5, 2019 Category: Cancer & Oncology Source Type: research

Utility of Preoperative Imaging for Predicting Pelvic Lateral Lymph Node Metastasis in Lower Rectal Cancer
This study aimed to investigate the diagnostic power of preoperative imaging for lateral pelvic lymph node (LPLN) metastasis. A total of 79 patients with advanced lower rectal cancer were preoperatively examined with pelvic enhanced computed tomography and underwent primary resection and LPLN dissection (LPLD) from 2007 to 2014 in our institute. The maximum LPLN was selected to be measured in both the long- and short-axis diameters by picture archiving and communication system (PACS) and was compared with the histopathological results. Receiver operating characteristic (ROC) curves were used to identify the optimal cut-off...
Source: Indian Journal of Surgical Oncology - June 3, 2019 Category: Cancer & Oncology Source Type: research

Near-Total Laryngectomy for Extranodal Infiltration from Papillary Cancer to Larynx and Hypopharynx
We report a rare case where an extranodal extension from a metastatic papillary thyroid cancer infiltrated into the larynx and pyriform sinus in a 56-year-old female. Near-total laryngectomy with partial pharyngectomy was done for gross removal of the disease to achieve long-term locoregional disease-free survival. Although locally advanced thyroid cancer is rare, once noted, it presents challenge to the surgeon to achieve gross total removal of the tumor. Initial radical resection should be done to achieve gross total removal of the cancer. (Source: Indian Journal of Surgical Oncology)
Source: Indian Journal of Surgical Oncology - May 16, 2019 Category: Cancer & Oncology Source Type: research

Infrahyoid Myofasciocutaneous Flap for Reconstruction of Tongue Defects: Our Experience and Perspective
(Source: Indian Journal of Surgical Oncology)
Source: Indian Journal of Surgical Oncology - May 16, 2019 Category: Cancer & Oncology Source Type: research

Perioperative Artificial Enteral Nutrition in Malnourished Esophageal and Stomach Cancer Patients and Its Impact on Postoperative Complications
In conclusion, perioperative nutrition support can decrease the incidence of postoperative complications in moderately and severely malnourished gastric and esophageal cancer patients. In addition, it is effective in reducing mortality. Enteral nutrition support alone can be us ed in the management of malnourished patients undergoing gastric and esophageal surgery. (Source: Indian Journal of Surgical Oncology)
Source: Indian Journal of Surgical Oncology - May 11, 2019 Category: Cancer & Oncology Source Type: research

Massive Bilateral Maxillary Osteosarcoma: a Dramatic Clinical Presentation and a Reconstructive Challenge
(Source: Indian Journal of Surgical Oncology)
Source: Indian Journal of Surgical Oncology - May 10, 2019 Category: Cancer & Oncology Source Type: research

Retrospective Audit of Various Surgical Modalities Adopted for Giant Cell Tumor in a Rural Tertiary Cancer Center
AbstractGiant cell tumor of bone (GCTB) is a rare tumor with a spectrum of clinical behavior. Standard treatment modalities include surgical curettage to wide resection, and varying oncological and functional results have been reported. The aim of this study was to evaluate the functional outcome and recurrence rates of patients who underwent surgery for giant cell tumor in a rural tertiary cancer center from June 2009 to December 2016. A retrospective review of 12 patients (7 males and 5 females) with GCT of the extremity bones treated in the institution between the period of June 2009 and December 2016 was performed to s...
Source: Indian Journal of Surgical Oncology - May 6, 2019 Category: Cancer & Oncology Source Type: research

Thoracoabdominal Flap: a Simple Flap for Covering Large Post-mastectomy Soft Tissue Defects in Locally Advanced Breast Cancer
We present our experience of TA flap cover for large post-mastectomy defect s. A retrospective analysis of prospectively maintained breast cancer database in the Department of Surgical Oncology from January 1994 to December 2017 at All India Institute of Medical Sciences, New Delhi, was performed. The medical records of patients undergoing TA flap cover were analyzed to ass ess operative duration, blood loss, post-operative morbidity, hospital stay, adjuvant treatment, recurrence patterns, and survival outcome. A total of 3142 breast cancer patients underwent surgery, of which 1840 were LABC and 88 patients (4.13%) of LABC...
Source: Indian Journal of Surgical Oncology - May 2, 2019 Category: Cancer & Oncology Source Type: research

Ovarian Sertoli-Leydig Cell Tumor with Estrogenic Manifestations in a Postmenopausal Lady: a Case Report
(Source: Indian Journal of Surgical Oncology)
Source: Indian Journal of Surgical Oncology - May 2, 2019 Category: Cancer & Oncology Source Type: research

A Pioneer of Surgical Oncology in India —a Tribute to Dr Mrs Mehta
(Source: Indian Journal of Surgical Oncology)
Source: Indian Journal of Surgical Oncology - May 1, 2019 Category: Cancer & Oncology Source Type: research

Can Preoperative Ultrasonography and MRI Replace Sentinel Lymph Node Biopsy in Management of Axilla in Early Breast Cancer —a Prospective Study from a Tertiary Cancer Center
AbstractAlthough SLNB is a less invasive procedure in detecting axillary lymph node metastases(ALNM) in early breast cancer; still, it carries some complications like lymphedema and in addition, performing SLNB requires surgical skills, technical knowledge, presence of facility like preoperative sentinel lymphoscintigraphy, and availability of hand-held gamma probe for intraoperative assessment. We calculated the relative diagnostic strength of preoperative axillary USG and MRI and compared with of SLNB for detection of ALNM in early breast cancer and assessed whether MRI and USG could accurately predict axillary LN status...
Source: Indian Journal of Surgical Oncology - April 27, 2019 Category: Cancer & Oncology Source Type: research

Life Quality Index Assessment in Breast Cancer Patients
AbstractBreast cancer (BC) is the most common cancer in Indian females whether they are from urban or rural area. Quality of life after treatment in BC patients is a very vital issue as its assessment will guide the clinicians, hospital authorities, and administrators to take appropriate steps to improve the delivery of treatment and address the concern. Improvement in QOL should be one of the ultimate aims of treatment in BC. The aim of this review is to collect and examine literature available on QOL in breast cancer patients and define what type of issues or domains should be studied. Four factors including chemotherapy...
Source: Indian Journal of Surgical Oncology - April 16, 2019 Category: Cancer & Oncology Source Type: research

Hypoxic Isolated Abdominal Perfusion (HAP) chemotherapy for non-operable advanced staged ovarian cancer with peritoneal carcinosis: an experience in 45 platinum-refractory ovarian cancer patients
AbstractIn order to break through drug resistance in platinum-refractory ovarian cancer, augmented drug exposure was administered to the abdomen by means of  an isolated perfusion system. Four cycles of isolated hypoxic abdominal perfusion with cisplatin, adriamycin, and mitomycin were conducted in 4-week intervals. Cisplatin and adriamycin were chosen because of their increased cytotoxicity under hypoxic conditions. Chemofiltration was performed for p rophylaxis of cumulative toxicity of adriamycin and mitomycin. The study included 45 patients with recurrent epithelial ovarian cancer who had prior platinum containing...
Source: Indian Journal of Surgical Oncology - April 16, 2019 Category: Cancer & Oncology Source Type: research

Correction to: Assessment Awareness of Public About Breast Cancer and its Screening Measurements in Asir Region, KSA
With the author(s) ’ decision to step back from Open Choice, the copyright of the article changed on April 2019 to © Indian Association of Surgical Oncology 2019 and the article is forthwith distributed under the terms of copyright. (Source: Indian Journal of Surgical Oncology)
Source: Indian Journal of Surgical Oncology - April 15, 2019 Category: Cancer & Oncology Source Type: research

Fatigue and Functional Ability in Patients Undergoing Upfront Surgical Treatment for Solid Malignancies
This study was designed to evaluate the level of fatigue in pre- and post-surgery period and its relation with the functional disability in patients undergoing upfront surgery for solid malignancies. A prospective observational study was conducted between 2016 and 2017. A total of 71 patients with malignant solid tumors (up to stage III) undergoing upfront surgery were included. The fatigue and functional disability were assessed in pre- and post-surgery period using Multidimensional Fatigue Inventory-20 (MFI-20) and Functional Assessment of Chronic Illness Therapy (FACIT-F) questionnaires respectively. The mean age was 42...
Source: Indian Journal of Surgical Oncology - April 13, 2019 Category: Cancer & Oncology Source Type: research

Do Acellular Mucin Pools in Resection Margins for Rectal Cancer Influence Outcomes?
AbstractPositive resection margins predict poor prognosis in rectal cancer (RC). Literature on the impact of acellular mucin (ACM) in circumferential resection margin (CRM) or distal resection margin (DRM) of proctectomy specimens on RC recurrence and outcomes is lacking. The retrospective study was conducted to determine the oncological outcomes of the RC patients with ACM in or within 1  mm of margins of the rectal resection specimens. Histopathology reports of RC resection specimens dated from June 2013 till May 2016 were reviewed to identify cases with ACM in CRM (n = 10) and DRM (n = 2...
Source: Indian Journal of Surgical Oncology - April 13, 2019 Category: Cancer & Oncology Source Type: research

Utility of WhatsApp as a Tool for Tele-oncopathology for Oral Lesions
AbstractTraditional telepathology techniques like whole slide imaging and robotic microscopy are too expensive to be used in developing countries. With the advent of smartphones with high-resolution cameras and faster internet services, it is now possible to send good-quality images to pathologist for diagnosis. To study the utility of WhatsApp image transfer in the histopathological diagnosis of common oral malignant and benign lesions. A total of 100 cases of oral biopsy were included in the study. These comprised of 58 cases of squamous cell carcinoma, 33 cases of oral leukoplakia, 3 cases of oral lichen planus and 6 ca...
Source: Indian Journal of Surgical Oncology - April 7, 2019 Category: Cancer & Oncology Source Type: research