Indian Journal of Surgical Oncology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Extramammary Paget ’s Disease of the Penis and Scrotum
AbstractExtramammary Paget ’s disease (EMPD) is an adenocarcinoma arising from the skin or skin appendages which is sometimes associated with an underlying malignancy. EMPD is most commonly seen in the vulva, followed by perianal region, and the male genitalia. In most cases, patient presents with eczematous lesion persisti ng for long duration. A 77-year-old gentleman had a history of chronic eczematous lesion over penis and scrotum for the last 10 years. Examination revealed an erythematous plaque like eczematous lesion over the penis and scrotum. Biopsy with IHC of lesion is suggestive of EMPD. Wide local excision of...
Source: Indian Journal of Surgical Oncology - January 23, 2024 Category: Cancer & Oncology Source Type: research

Our Experience of OSAKA Regimen (Bladder Preservation) in Patients with Advanced Bladder Cancer
ConclusionsThe OSAKA regimen, as a bladder preservation strategy, is feasible and safe in selective advanced Ca Bladder patients. (Source: Indian Journal of Surgical Oncology)
Source: Indian Journal of Surgical Oncology - January 22, 2024 Category: Cancer & Oncology Source Type: research

Long-Term Complete Response with Single-Agent Capecitabine in Her-2-neu-Positive Metastatic Breast Cancer —A Rare Case Report
AbstractThe standard treatment approach for metastatic breast cancer with HR- and Her-2-neu + disease is trastuzumab with systemic therapy. But in patients having severe cardiac dysfunction, trastuzumab is avoided. Various combination regimens are available in that setting, but no study has shown better efficacy of capecitabine monotherapy in this setting. We hereby present a case report of using capecitabine monotherapy in first-line setting, and the patient had complete resolution of lung metastasis from the last 2 years. A 64-year-old postmenopausal lady with a known case of breast carcinoma in the left side diagnosed i...
Source: Indian Journal of Surgical Oncology - January 20, 2024 Category: Cancer & Oncology Source Type: research

Local Flaps in Breast-Conserving Surgery in Early Breast Cancer Patients: Armamentarium for Breast Surgeon
AbstractTo describe the technique and outcome of local perforator arteries advancement flap in breast-conserving surgeries (BCS) in patient of early breast cancer as our initial experience and review of literature on it. Patients who underwent (BCS) with local perforator artery flap reconstruction were reviewed in terms of their clinical, surgical, and post-operative follow-up details after taking written and informed consent. We have described 4 patients of early breast cancer out of which one patient was post-NACT while 3 were for upfront BCS. We have performed LICAP in 2 patients, AICAP in 1 patient, and IMAP in one pat...
Source: Indian Journal of Surgical Oncology - January 19, 2024 Category: Cancer & Oncology Source Type: research

Outcomes of Robotic Surgery in a Single-institution, High-volume Hepatobiliary Oncology Unit
We present our experience with the Da Vinci Xi system in hepatobiliary oncology. This is a retrospective study from a prospectively maintained database. All patients who underwent surgery between June 2015 and July 2023 for suspected gallbladder cancer and primary or metastatic liver tumors were included. After excluding all inoperables and conversions, a total of 92 patients were included for analysis. There was a conversion rate of 15.6% (17 of 109 patients). Sixty-four (69.6%) patients underwent surgery for gallbladder-related pathologies that included 39 (60.9%) radical cholecystectomies, 24 (37.5%) simple cholecystect...
Source: Indian Journal of Surgical Oncology - January 16, 2024 Category: Cancer & Oncology Source Type: research

Incidence and Prognostic Significance of Androgen Receptors (AR) in Indian Triple-Negative Breast Cancer (TNBC)
AbstractBackgroundMolecular sub-characterization of triple-negative breast cancer (TNBC) has great therapeutic and possibly prognostic implications. The primary aim of this study was to investigate the incidence of luminal androgen receptor (LAR)  subtype of TNBC and secondary aims were sub-categorization and clinico-pathologic correlation of LAR breast cancers. Retrospective study (January 2008 and 31st of December 2018) consisting of 157 TNBC patients. Androgen receptor (AR) expression was measured by immunohistochemical analysis. One percent cutoff was set as a positive expression. Sub-categorization was done on the b...
Source: Indian Journal of Surgical Oncology - January 15, 2024 Category: Cancer & Oncology Source Type: research

Real-World Experience of Patient ’s Compliance and Clinical Outcomes for Trimodality Treatment for Esophageal Cancer: a Study from a Cancer Center in North-East India
AbstractPreoperative chemoradiotherapy is a standard treatment for patients with locally advanced, resectable esophageal cancer. The treatment completion rates impact the survival outcomes (Eyck et al  J Clin Oncol 39(18):1995–2004,2021). Thus, we aimed to estimate the effect of neoadjuvant chemoradiotherapy (NACRT) in terms of treatment completion rates and survival in this subset of patients and bring out the clinical outcomes in that context. This was a retrospective study done at a tertiary cancer center in North-East India. The study period was from 1 January 2018 to 31 December 2021. We included patients diagnosed...
Source: Indian Journal of Surgical Oncology - January 13, 2024 Category: Cancer & Oncology Source Type: research

Evaluation of Histomorphological Changes in Breast Cancer Post-Neoadjuvant Chemotherapy
In conclusion, this retrospective study provides a comprehensive overview of post-neoadjuvant chemotherapy breast cancer specimens, shedding light o n the intricate interplay of clinical parameters, treatment responses, and histopathological changes. The findings underscore the pivotal role of pathologists in accurately diagnosing and grading tumors in the evolving landscape of breast cancer management. (Source: Indian Journal of Surgical Oncology)
Source: Indian Journal of Surgical Oncology - January 12, 2024 Category: Cancer & Oncology Source Type: research

Epithelioid Hemangioma of the Nasal Cavity: a Diagnostic Challenge
AbstractEpithelioid hemangioma also known as angio-lymphoid hyperplasia with eosinophilia is a rare benign vascular neoplasm of unknown etiology. It very rarely involves the nasal cavity. It always poses a diagnostic challenge for clinicians and is usually misdiagnosed as Kimura ’s, IgG4-related disease, or malignant vascular tumors. The present case report describes an extremely rare presentation of epithelioid hemangioma inside the left nasal cavity causing complete obstruction and nasal septal deviation towards the right side in a young male. Hematoxylin and eosin-stai ned sections depicted a lobular proliferation of ...
Source: Indian Journal of Surgical Oncology - January 10, 2024 Category: Cancer & Oncology Source Type: research

Role of Intraoperative Frozen Section Assessment of Proximal Bile Duct Margins and the Impact of Additional Re-Resection in Perihilar Cholangiocarcinomas
AbstractIntraoperative frozen section (FS) analysis to assess the bile duct margin status is commonly used to assess the completeness of resection during surgery for perihilar cholangiocarcinoma (pCCA) resection. However, the impact of additional re-section on the long-term outcome after obtaining an initial positive margin remains unclear. Patients diagnosed as pCCA on preoperative imaging and subjected to curative intent surgery from May 2013 to June 2021 with a minimum follow-up of 2  years were included. Intraoperative FS analysis of the proximal bile duct margin was performed in all patients. A positive margin was de...
Source: Indian Journal of Surgical Oncology - January 9, 2024 Category: Cancer & Oncology Source Type: research

A Case of Medullary Carcinoma of Colon Morphologically Resembling Non-Hodgkin ’s Lymphoma
AbstractMedullary carcinoma of the colon is an unusual and unique histologic subtype of colorectal cancer. It is strongly associated with microsatellite instability, most commonly loss of MLH1 indicative of deficient mismatch repair proteins. Diagnosis is challenging as they do not display the usual histological pattern. Immunohistochemical staining also shows unusual findings like negativity for CD20 and CDX2. Here, we explore an intriguing case of medullary carcinoma of colon which showed loss of MSH2 and MSH6 and a morphology reminiscent of Non-Hodgkin ’s lymphoma. (Source: Indian Journal of Surgical Oncology)
Source: Indian Journal of Surgical Oncology - January 5, 2024 Category: Cancer & Oncology Source Type: research

Intra-abdominal Inflammatory Myofibroblastic Tumour (IMFT) —Uncommon Entity
We report a case of multifocal IMFT affecting the GI tract which was managed with gross total excision followed by chemotherapy. Surgical resection remains the treatment of choice. The role of chemotherapy and radiation therapy remains limited. The aetiology of these tumours remains unclear and is mostly ALK-positive that could be targeted. Local recurrences are common and hence require close follow-up. The risk of recurrences and metastasis is increased in cases with TP53 positivity, aneuploidy and recurrent lesions. (Source: Indian Journal of Surgical Oncology)
Source: Indian Journal of Surgical Oncology - January 5, 2024 Category: Cancer & Oncology Source Type: research

Impact of Implementing Paris System on Diagnostic Precision and Management of Urinary Bladder Neoplasms
This study was done to test the impact of implementing TPS categories and criteria in comparison to our previously used system. TPS is one of the important deciding factors for the management of the patient. The management of patients with AUC diagnosis often varies depending on the treating physician (urologist/nonurologist). For further categorization of the diagnosis of AUC, markers like p53 and Ki67 can be used. One hundred urinary cytology specimens received for the period of 6  months were included in the study. The presentation of the categorical variables was done in the form of numbers and percentages (%). Interr...
Source: Indian Journal of Surgical Oncology - January 4, 2024 Category: Cancer & Oncology Source Type: research

Biomarker in Hepatocellular Carcinoma
AbstractLiver cancer is one of the most prevalent types of cancer and a major contributor to the socioeconomic burden worldwide. The pathogenesis of hepatocellular carcinoma (HCC) is contributed by various etiological factors like virus infection, excessive alcohol consumption, exposure to toxins, or metabolic disorders. Majority of patients are diagnosed with late-stage HCC, which restricts its management to only palliative care. HCC, if diagnosed early, increases the survival and quality of life. Currently available biomarker (alpha-fetoproteins) have several limitations, that impede the early diagnosis and staging of ca...
Source: Indian Journal of Surgical Oncology - January 2, 2024 Category: Cancer & Oncology Source Type: research

Role of Endoscopic Ultrasound in the Management of Pancreatic Cancer
AbstractPancreatic cancer is one of the common causes of cancer-associated mortality with a dismal overall prognosis which has remained virtually unchanged over decades. In the present era, the management of patients with pancreatic cancer involves a multi-disciplinary team of radiologists, gastroenterologists, surgical oncologists, medical oncologists, radiation oncologists and other specialists. The advancement of interventional endoscopy has made a significant impact in the management of pancreatic cancers. Since the inception of endoscopic ultrasound, it has evolved over the last few decades in the management of pancre...
Source: Indian Journal of Surgical Oncology - December 30, 2023 Category: Cancer & Oncology Source Type: research