Practice of Tumor Bed Boost in Patients after Oncoplastic Breast-Conserving Surgery
AbstractThe practice of boost to the tumor bed after treatment with oncoplastic breast-conserving surgery (BCS) remains variable. Using a survey, the present study evaluated the current practice of tumor bed boost administered in women after oncoplastic BCS. Actively practicing radiation oncologists across India were sent a questionnaire on the practice of adjuvant whole-breast radiotherapy and tumor bed boost after oncoplastic BCS via email and encouraged to participate. Of the 54 radiation oncologists who participated, most (98.1%) used a linear accelerator for radiotherapy. Hypofractionation was preferred by 59.26%, sta...
Source: Indian Journal of Surgical Oncology - October 4, 2023 Category: Cancer & Oncology Source Type: research

Is Ki-67 Really Useful as a Predictor for Response to Neoadjuvant Chemotherapy in Locally Advanced Breast Cancer?
AbstractNeoadjuvant chemotherapy (NACT) is routinely offered to operable locally advanced breast cancer (LABC) patients desirous of breast conservation surgery and inoperable LABC patients. Pathological complete response (pCR) following chemotherapy is recognized as a surrogate for survival outcomes in high grade tumour subtypes. Many biological and tumor characters have been shown to predict pCR. The current study was performed with the aim of investigating the ability of Ki-67 in predicting pCR with NACT in breast cancer patients. A total of 105 patients with locally advanced breast cancer who completed NACT followed by ...
Source: Indian Journal of Surgical Oncology - September 29, 2023 Category: Cancer & Oncology Source Type: research

A Comparison of Two Methods of Pre-operative Inspiratory Muscle Training on Post-operative Outcome Following Esophagectomy
This study was planned to compare and analyze the outcome of two different protocols of preoperative IMT program on the rate of PPCs in patients undergoing esophagectomy. Twenty patients who underwent esophagectomy for carcinoma esophagus were included in the study and were randomly divided into 2 groups of 10 each. Group A received IMT-HI training for 4  weeks, whereas the group B received IMT-E training for 4 weeks pre-operatively. All the patients included in the study underwent a baseline pulmonary assessment which included pulmonary function test (FVC, FEV1, and FEV1/FVC), maximum inspiratory pressure (MIP), and max...
Source: Indian Journal of Surgical Oncology - September 25, 2023 Category: Cancer & Oncology Source Type: research

Prognostic Implications of Various Surgical Procedures and Postoperative Margin Status in Gastroesophageal Junction Tumors
AbstractEsophagogastric junction (EGJ) carcinomas often require access to two compartments of the body for good margin and lymphadenectomy. Whether it is required to do so in all patients is debatable. We analyzed outcomes of patients who underwent surgeries for EGJ carcinomas in terms of margin status and survival. This is a retrospective analysis of a prospectively maintained database of patients with EGJ adenocarcinomas operated between January 2014 and December 2016. Type of surgery performed and its impact on margin status and survival were assessed. Follow-up was for a minimum of 5 years. Ninety-four patients with EG...
Source: Indian Journal of Surgical Oncology - September 23, 2023 Category: Cancer & Oncology Source Type: research

A Nationwide Survey to Assess the Practices and Patterns of Use of Intraoperative Nerve Monitoring During Thyroid Surgery Among Surgeons in India
AbstractThere is still equipoise for the routine use of intraoperative nerve monitoring (IONM) for thyroid surgeries; however, some surgeons tend to use it for various reasons. In our study, we did a national survey to assess the patterns and practice of the use of IONM among surgeons during thyroid surgery in India. A questionnaire survey was sent to surgeons (head and neck surgical oncologists, general surgical oncologists, endocrine surgeons and otolaryngologists) in different zones in India via email, and their responses were analysed. One hundred and one responses were received. The majority of the respondents were he...
Source: Indian Journal of Surgical Oncology - September 21, 2023 Category: Cancer & Oncology Source Type: research

Expression Profile of KRAS and p16 in Periampullary Cancer
AbstractActivating point mutations in codons 12, 13, and 61 of the KRAS gene and loss of p16 expression, a tumor suppressor gene, are common genetic alterations in periampullary cancer (PAC). The present study explores expression profile of KRAS and p16 genes in PAC and its prognostic relevance. A total of 50 patients with PAC who underwent potentially curative pancreaticoduodenectomy were included in the study. Formalin-fixed, paraffin-embedded tissue samples were analyzed for point mutations in codons 12 and 13 of KRAS and codon 9 of p16 using polymerase chain reaction. KRAS mutation in codon 12/13 was found in 32 (64%) ...
Source: Indian Journal of Surgical Oncology - September 15, 2023 Category: Cancer & Oncology Source Type: research

Ossifying Fibroma of Rib Masquerading as Hydatid Cyst —a Rare Case Report
(Source: Indian Journal of Surgical Oncology)
Source: Indian Journal of Surgical Oncology - September 15, 2023 Category: Cancer & Oncology Source Type: research

Factors that Impact the Outcomes in Ewing ’s Sarcoma: Experience from a Regional Cancer Center in Southern India
We report the clinico-pathological features, treatment, and survival outcomes of patients with EWSFT treated at our center. Patients diagnosed and treated for EWSFT at our center from 2009–2017 were included in this study. Data was collected from the patient’s case records. Event-free survival (EFS) and overall survival (OS) were estimated using the Kaplan–Meier method. The study included 173 patients among whom 44 (25%) patients were metastati c at diagnosis. The median age of patients was 16 years. The most common site of the primary tumor was the pelvis (16.1%), followed by long bones. The median follow-up was 75...
Source: Indian Journal of Surgical Oncology - September 13, 2023 Category: Cancer & Oncology Source Type: research

Acantholytic Squamous Cell Carcinoma: a Diagnostic Pitfall on Cytology
AbstractAcantholytic squamous cell carcinoma is an infrequent subtype of squamous cell carcinoma. This tumour variant being rare in itself has been rarely described at the penile location, thus leading to a limitation on information of pathological and immunohistochemical findings and prognosis. Clinical observations indicate an aggressive biologic behaviour. The cytological features on fine-needle aspiration cytology samples have rarely been described in literature. It is imperative for pathologists to be aware of the cytological features so as to allow the distinction of this variant from conventional squamous carcinoma....
Source: Indian Journal of Surgical Oncology - September 12, 2023 Category: Cancer & Oncology Source Type: research

Platysma Sign: A Feature of Extra-capsular Spread
AbstractA 60-year-old gentleman presented with a large swelling on the left side of his neck which was diagnosed as a metastatic cervical lymph node. It infiltrated the platysma muscle and caused partial contracture. This is known as Platysma sign. Presence of this sign indicates extracapsular spread and shows poor prognosis. (Source: Indian Journal of Surgical Oncology)
Source: Indian Journal of Surgical Oncology - September 12, 2023 Category: Cancer & Oncology Source Type: research

Reconstruction of Intercalary Bone Defects After Tumour Resection with the Use of a Free Vascularised Fibular Graft: the Concealed Advantages of the External Fixator
AbstractThe free vascularised fibular graft represents the mainstay of intercalary bone defect reconstruction after tumour resection. Different reconstruction techniques are described, favouring internal fixation and possibly overlooking potential advantages of external fixation. This series is a description of the technique performed at our institution using an external fixator for the reconstruction of segmental bone defects which enables to maintain limb length and rotational alignment after large segmental bone resection. Data collected were demographic, surgical and histological data, perioperative complications and p...
Source: Indian Journal of Surgical Oncology - September 8, 2023 Category: Cancer & Oncology Source Type: research

Syringocystadenocarcinoma Papilliferum of Thigh —a Rare Cutaneous Malignancy with Unusual Histology and Clinical Presentation
(Source: Indian Journal of Surgical Oncology)
Source: Indian Journal of Surgical Oncology - September 6, 2023 Category: Cancer & Oncology Source Type: research

Latissimus Dorsi kiss Flap for Reconstruction of Large Chest Wall Defect —an Underutilized Option?
AbstractThe utility of pedicled latissimus dorsi kiss flap for the reconstruction of chest wall defect is still an underutilized option. But the peculiar design and structure of the kiss flap with two semicircular flaps of equal diameter with same vascular trunk makes it amenable to cover large chest wall defects especially at places where plastic surgery facility is unavailable. We have used this flap to reconstruct large chest wall defect of size 20 ×18 cm in our patient operated for recurrent chest wall dermatofibrosarcoma protuberans. In the follow-up, both recipient kiss latissimus dorsi flap and donor site flap heal...
Source: Indian Journal of Surgical Oncology - September 1, 2023 Category: Cancer & Oncology Source Type: research

Major Nerve Resections in Extremity Soft Tissue Sarcomas —Functional and Oncological Outcomes
We present our data of major nerve resection without amputation, in an attempt to demonstrate the possibility of equivalent functional and oncological outcomes in these rare tumors. A total of 86 cases of extremity soft tissue sarcomas were operated on during the period September 2019 to September 2022, of which there were 12 cases of major nerve resections of the lower extremity. These patients were followed up and their clinicopathological data collected and analyzed. The functional outcome was recorded at different intervals. Of the 12 patients who underwent nerve resection along with the tumor, only 1 patient developed...
Source: Indian Journal of Surgical Oncology - August 29, 2023 Category: Cancer & Oncology Source Type: research

A Review of Commonly used Health-Related Quality of Life instruments in Gynecological Cancer Survivors
AbstractThe number of cancer survivors is increasing steadily due to an aging population, continuing improvement in early detection, and treatment. Comparative effectiveness studies and clinical trials are being done to assess late effects of treatment and health-related quality of life. This is in addition to long-term follow-up to assess survival. The aim of the review was to summarize the literature on commonly used quality of life instruments for patients with gynecological cancers with special focus on patient reported outcomes. A literature review was done to summarize the commonly used health-related quality of life...
Source: Indian Journal of Surgical Oncology - August 28, 2023 Category: Cancer & Oncology Source Type: research