A planetary health model for reducing exposure to faecal contamination in urban informal settlements: Baseline findings from Makassar, Indonesia
Environ Int. 2021 Jun 11;155:106679. doi: 10.1016/j.envint.2021.106679. Online ahead of print.ABSTRACTBACKGROUND: The intense interactions between people, animals and environmental systems in urban informal settlements compromise human and environmental health. Inadequate water and sanitation services, compounded by exposure to flooding and climate change risks, expose inhabitants to environmental contamination causing poor health and wellbeing and degrading ecosystems. However, the exact nature and full scope of risks and exposure pathways between human health and the environment in informal settlements are uncertain. Exi...
Source: Environment International - June 14, 2021 Category: Environmental Health Authors: Matthew A French S Fiona Barker Ruzka R Taruc Ansariadi Ansariadi Grant A Duffy Maghfira Saifuddaolah Andi Zulkifli Agussalim Fitriyanty Awaluddin Zainal Zainal Jane Wardani Peter A Faber Genie Fleming Emma E Ramsay Rebekah Henry Audrie Lin Joanne O'Toole Source Type: research

Effects of single and combined gestational phthalate exposure on blood pressure, blood glucose and gestational weight gain: A longitudinal analysis
In conclusion, exposure to single and multiple phthalates during the first trimester of pregnancy increased the risks of maternal metabolic syndrome components. However, the conflicting findings between phthalates and their metabolites need to be interpreted carefully.PMID:34126297 | DOI:10.1016/j.envint.2021.106677 (Source: Environment International)
Source: Environment International - June 14, 2021 Category: Environmental Health Authors: Hui Gao Bei-Bei Zhu Kun Huang Yuan-Duo Zhu Shuang-Qin Yan Xiao-Yan Wu Yan Han Jie Sheng Hui Cao Peng Zhu Fang-Biao Tao Source Type: research

Evaluation of DNA damage and stress in wildlife chronically exposed to low-dose, low-dose rate radiation from the Fukushima Dai-ichi Nuclear Power Plant accident
Environ Int. 2021 Jun 10;155:106675. doi: 10.1016/j.envint.2021.106675. Online ahead of print.ABSTRACTThe health effects associated with chronic low-dose, low-dose rate (LD-LDR) exposures to environmental radiation are uncertain. All dose-effect studies conducted outside controlled laboratory conditions are challenged by inherent complexities of ecological systems and difficulties quantifying dose to free-ranging organisms in natural environments. Consequently, the effects of chronic LD-LDR radiation exposures on wildlife health remain poorly understood and much debated. Here, samples from wild boar (Sus scrofa leucomystax...
Source: Environment International - June 13, 2021 Category: Environmental Health Authors: Kelly Cunningham Thomas G Hinton Jared J Luxton Aryn Bordman Kei Okuda Lynn E Taylor Josh Hayes Hannah C Gerke Sarah M Chinn Donovan Anderson Mark L Laudenslager Tsugiko Takase Yui Nemoto Hiroko Ishiniwa James C Beasley Susan M Bailey Source Type: research

Gestational acrylamide exposure and biomarkers of fetal growth: Probing the mechanism underlying the association between acrylamide and reduced fetal growth
CONCLUSIONS: A decrease in cord plasma insulin levels may be (a marker of) a mechanism by which gestational acrylamide exposure is associated with decreased fetal growth. The possible health consequences of the associations between gestational acrylamide exposure and thyroid hormones and neurotrophins warrant future study.PMID:34120003 | DOI:10.1016/j.envint.2021.106668 (Source: Environment International)
Source: Environment International - June 13, 2021 Category: Environmental Health Authors: Janneke G F Hogervorst Nelly D Saenen Tim S Nawrot Source Type: research

Paternal preconception phthalate exposure alters sperm methylome and embryonic programming
Environ Int. 2021 Jun 10;155:106693. doi: 10.1016/j.envint.2021.106693. Online ahead of print.ABSTRACTPreconception environmental conditions have been demonstrated to shape sperm epigenetics and subsequently offspring health and development. Our previous findings in humans showed that urinary anti-androgenic phthalate metabolites in males were associated with altered sperm methylation and blastocyst-stage embryo development. To corroborate this, we examined the effect of preconception exposure to di(2-ethylhexyl) phthalate (DEHP) on genome-wide DNA methylation and gene expression profiles in mice. Eight-week old C57BL/6J m...
Source: Environment International - June 13, 2021 Category: Environmental Health Authors: Oladele A Oluwayiose Chelsea Marcho Haotian Wu Emily Houle Stephen A Krawetz Alexander Suvorov Jesse Mager J Richard Pilsner Source Type: research

Relative contribution of rice and fish consumption to bioaccessibility-corrected health risks for urban residents in eastern China
Environ Int. 2021 Jun 10;155:106682. doi: 10.1016/j.envint.2021.106682. Online ahead of print.ABSTRACTThere are global concerns about dietary exposure to metal(loid)s in foods. However, little is known about the relative contribution of rice versus fish to multiple metal(loid) exposure for the general population, especially in Asia where rice and fish are major food sources. We compared relative contributions of rice and fish consumption to multi-metal(loid) exposure on the city-scale (Nanjing) and province-scale in China. The effects of ingestion rate, metal(loid) level, and bioaccessibility were examined to calculate mod...
Source: Environment International - June 13, 2021 Category: Environmental Health Authors: Wenqin Wang Yu Gong Ben K Greenfield Lu ís M Nunes Qianqi Yang Pei Lei Wenbo Bu Bin Wang Xiaomiao Zhao Lei Huang Huan Zhong Source Type: research

Early pregnancy essential and non-essential metal mixtures and gestational glucose concentrations in the 2nd trimester: Results from project viva
This study explored the joint associations of pregnancy exposures to essential (copper, magnesium, manganese, selenium, zinc) and non-essential (arsenic, barium, cadmium, cesium, lead, mercury) metals with gestational glucose concentrations using 1,311 women enrolled 1999-2002 in Project Viva, a Boston, MA-area pregnancy cohort. The study measured erythrocyte metal concentrations from 1st trimester blood samples and used glucose concentrations measured 1 h after non-fasting 50-gram glucose challenge tests (GCT) from clinical gestational diabetes screening at 26-28 weeks gestation. Bayesian Kernel Machine Regression (BKMR) ...
Source: Environment International - June 13, 2021 Category: Environmental Health Authors: Yinnan Zheng Pi-I Debby Lin Paige L Williams Marc G Weisskopf Andres Cardenas Sheryl L Rifas-Shiman Robert O Wright Chitra Amarasiriwardena Birgit Claus Henn Marie-France Hivert Emily Oken Tamarra James-Todd Source Type: research

Analysis of elimination half-lives in MamTKDB 1.0 related to bioaccumulation: Requirement of repeated administration and blood plasma values underrepresent tissues
Environ Int. 2021 Jun 10;155:106592. doi: 10.1016/j.envint.2021.106592. Online ahead of print.ABSTRACTWhen building the novel public mammalian toxicokinetic database (MamTKDB) we collected and included 3927 elimination half-lives (elimt1/2) for 1407 xenobiotics in various species (rat, human, mouse, dog, monkey, rabbit, cattle, pig, sheep, guinea pig, hamster, horse and goat) with specification of compartment (whole body, organ/tissue, cell type, medium) studied. Here we describe and analyse the collected data in MamTKDB 1.0. Most elimt1/2 are for humans and rats and their data differ in some ways: whereas the rat data are...
Source: Environment International - June 13, 2021 Category: Environmental Health Authors: Tim Hofer Oddvar Myhre Johanna Peltola-Thies Doris Hirmann Source Type: research

Evaluation of DNA damage and stress in wildlife chronically exposed to low-dose, low-dose rate radiation from the Fukushima Dai-ichi Nuclear Power Plant accident
Environ Int. 2021 Jun 10;155:106675. doi: 10.1016/j.envint.2021.106675. Online ahead of print.ABSTRACTThe health effects associated with chronic low-dose, low-dose rate (LD-LDR) exposures to environmental radiation are uncertain. All dose-effect studies conducted outside controlled laboratory conditions are challenged by inherent complexities of ecological systems and difficulties quantifying dose to free-ranging organisms in natural environments. Consequently, the effects of chronic LD-LDR radiation exposures on wildlife health remain poorly understood and much debated. Here, samples from wild boar (Sus scrofa leucomystax...
Source: Environment International - June 13, 2021 Category: Environmental Health Authors: Kelly Cunningham Thomas G Hinton Jared J Luxton Aryn Bordman Kei Okuda Lynn E Taylor Josh Hayes Hannah C Gerke Sarah M Chinn Donovan Anderson Mark L Laudenslager Tsugiko Takase Yui Nemoto Hiroko Ishiniwa James C Beasley Susan M Bailey Source Type: research

Gestational acrylamide exposure and biomarkers of fetal growth: Probing the mechanism underlying the association between acrylamide and reduced fetal growth
CONCLUSIONS: A decrease in cord plasma insulin levels may be (a marker of) a mechanism by which gestational acrylamide exposure is associated with decreased fetal growth. The possible health consequences of the associations between gestational acrylamide exposure and thyroid hormones and neurotrophins warrant future study.PMID:34120003 | DOI:10.1016/j.envint.2021.106668 (Source: Environment International)
Source: Environment International - June 13, 2021 Category: Environmental Health Authors: Janneke G F Hogervorst Nelly D Saenen Tim S Nawrot Source Type: research

Paternal preconception phthalate exposure alters sperm methylome and embryonic programming
Environ Int. 2021 Jun 10;155:106693. doi: 10.1016/j.envint.2021.106693. Online ahead of print.ABSTRACTPreconception environmental conditions have been demonstrated to shape sperm epigenetics and subsequently offspring health and development. Our previous findings in humans showed that urinary anti-androgenic phthalate metabolites in males were associated with altered sperm methylation and blastocyst-stage embryo development. To corroborate this, we examined the effect of preconception exposure to di(2-ethylhexyl) phthalate (DEHP) on genome-wide DNA methylation and gene expression profiles in mice. Eight-week old C57BL/6J m...
Source: Environment International - June 13, 2021 Category: Environmental Health Authors: Oladele A Oluwayiose Chelsea Marcho Haotian Wu Emily Houle Stephen A Krawetz Alexander Suvorov Jesse Mager J Richard Pilsner Source Type: research

Relative contribution of rice and fish consumption to bioaccessibility-corrected health risks for urban residents in eastern China
Environ Int. 2021 Jun 10;155:106682. doi: 10.1016/j.envint.2021.106682. Online ahead of print.ABSTRACTThere are global concerns about dietary exposure to metal(loid)s in foods. However, little is known about the relative contribution of rice versus fish to multiple metal(loid) exposure for the general population, especially in Asia where rice and fish are major food sources. We compared relative contributions of rice and fish consumption to multi-metal(loid) exposure on the city-scale (Nanjing) and province-scale in China. The effects of ingestion rate, metal(loid) level, and bioaccessibility were examined to calculate mod...
Source: Environment International - June 13, 2021 Category: Environmental Health Authors: Wenqin Wang Yu Gong Ben K Greenfield Lu ís M Nunes Qianqi Yang Pei Lei Wenbo Bu Bin Wang Xiaomiao Zhao Lei Huang Huan Zhong Source Type: research

Early pregnancy essential and non-essential metal mixtures and gestational glucose concentrations in the 2nd trimester: Results from project viva
This study explored the joint associations of pregnancy exposures to essential (copper, magnesium, manganese, selenium, zinc) and non-essential (arsenic, barium, cadmium, cesium, lead, mercury) metals with gestational glucose concentrations using 1,311 women enrolled 1999-2002 in Project Viva, a Boston, MA-area pregnancy cohort. The study measured erythrocyte metal concentrations from 1st trimester blood samples and used glucose concentrations measured 1 h after non-fasting 50-gram glucose challenge tests (GCT) from clinical gestational diabetes screening at 26-28 weeks gestation. Bayesian Kernel Machine Regression (BKMR) ...
Source: Environment International - June 13, 2021 Category: Environmental Health Authors: Yinnan Zheng Pi-I Debby Lin Paige L Williams Marc G Weisskopf Andres Cardenas Sheryl L Rifas-Shiman Robert O Wright Chitra Amarasiriwardena Birgit Claus Henn Marie-France Hivert Emily Oken Tamarra James-Todd Source Type: research

Analysis of elimination half-lives in MamTKDB 1.0 related to bioaccumulation: Requirement of repeated administration and blood plasma values underrepresent tissues
Environ Int. 2021 Jun 10;155:106592. doi: 10.1016/j.envint.2021.106592. Online ahead of print.ABSTRACTWhen building the novel public mammalian toxicokinetic database (MamTKDB) we collected and included 3927 elimination half-lives (elimt1/2) for 1407 xenobiotics in various species (rat, human, mouse, dog, monkey, rabbit, cattle, pig, sheep, guinea pig, hamster, horse and goat) with specification of compartment (whole body, organ/tissue, cell type, medium) studied. Here we describe and analyse the collected data in MamTKDB 1.0. Most elimt1/2 are for humans and rats and their data differ in some ways: whereas the rat data are...
Source: Environment International - June 13, 2021 Category: Environmental Health Authors: Tim Hofer Oddvar Myhre Johanna Peltola-Thies Doris Hirmann Source Type: research

Trends in environmental chemical concentrations in the Canadian population: Biomonitoring data from the Canadian Health Measures Survey 2007-2017
Environ Int. 2021 Jun 9;155:106678. doi: 10.1016/j.envint.2021.106678. Online ahead of print.ABSTRACTTen years of nationally representative biomonitoring data collected between 2007 and 2017 are available from the Canadian Health Measures Survey (CHMS). These data establish baseline environmental chemical concentrations in the general population. Here we sought to evaluate temporal trends in environmental chemical exposures in the Canadian population by quantifying changes in biomarker concentrations measured in the first five two-year cycles of the CHMS. We identified 39 chemicals that were measured in blood or urine in a...
Source: Environment International - June 12, 2021 Category: Environmental Health Authors: Tyler Pollock Subramanian Karthikeyan Mike Walker Kate Werry Annie St-Amand Source Type: research

Comparison of indoor and outdoor oxidative potential of PM < sub > 2.5 < /sub > : pollution levels, temporal patterns, and key constituents
We examined pollution levels, temporal variations, and key constituents of PM2.5 OP by DTT assay in both indoor and outdoor environments in Nanjing, China, for over one year. Outdoor OPM (mass-normalized OP characterizes toxicity) and OPV (volume-based OP characterizes overall oxidative burden) in Nanjing were at a medium level compared to results reported for twenty-seven cities. Although PM2.5 mass concentration consistently decreased during outdoor-to-indoor transport, OPM varied by a factor of up to 2 in either direction, indicating a change of PM2.5's ability to disrupt oxidative-reductive balance. Temporally, both ou...
Source: Environment International - June 12, 2021 Category: Environmental Health Authors: Fan Yang Cong Liu Hua Qian Source Type: research

Periconception air pollution, metabolomic biomarkers, and fertility among women undergoing assisted reproduction
Environ Int. 2021 Jun 8;155:106666. doi: 10.1016/j.envint.2021.106666. Online ahead of print.ABSTRACTBACKGROUND: Air pollution exposure has been linked with diminished fertility. Identifying the metabolic changes induced by periconception air pollution exposure among women could enhance our understanding of the potential biological pathways underlying air pollution's reproductive toxicity.OBJECTIVE: To identify serum metabolites associated with periconception air pollution exposure and evaluate the extent to which these metabolites mediate the association between air pollution and live birth.METHODS: We included 200 women ...
Source: Environment International - June 11, 2021 Category: Environmental Health Authors: Audrey J Gaskins Ziyin Tang Robert B Hood Jennifer Ford Joel D Schwartz Dean P Jones Francine Laden Donghai Liang EARTH Study Team Source Type: research

Maternal phthalate and phthalate alternative metabolites and urinary biomarkers of estrogens and testosterones across pregnancy
CONCLUSION: Phthalates/alternatives may impact gestational hormones, with potential for gestational age- and fetal sex-specific associations. Whether maternal urinary estrogens and testosterones mediate associations of phthalates/alternatives with pregnancy and fetal outcomes merits further investigation.PMID:34116379 | DOI:10.1016/j.envint.2021.106676 (Source: Environment International)
Source: Environment International - June 11, 2021 Category: Environmental Health Authors: Diana C Pacyga Joseph C Gardiner Jodi A Flaws Zhong Li Antonia M Calafat Susan A Korrick Susan L Schantz Rita S Strakovsky Source Type: research

Periconception air pollution, metabolomic biomarkers, and fertility among women undergoing assisted reproduction
Environ Int. 2021 Jun 8;155:106666. doi: 10.1016/j.envint.2021.106666. Online ahead of print.ABSTRACTBACKGROUND: Air pollution exposure has been linked with diminished fertility. Identifying the metabolic changes induced by periconception air pollution exposure among women could enhance our understanding of the potential biological pathways underlying air pollution's reproductive toxicity.OBJECTIVE: To identify serum metabolites associated with periconception air pollution exposure and evaluate the extent to which these metabolites mediate the association between air pollution and live birth.METHODS: We included 200 women ...
Source: Environment International - June 11, 2021 Category: Environmental Health Authors: Audrey J Gaskins Ziyin Tang Robert B Hood Jennifer Ford Joel D Schwartz Dean P Jones Francine Laden Donghai Liang EARTH Study Team Source Type: research

Maternal phthalate and phthalate alternative metabolites and urinary biomarkers of estrogens and testosterones across pregnancy
CONCLUSION: Phthalates/alternatives may impact gestational hormones, with potential for gestational age- and fetal sex-specific associations. Whether maternal urinary estrogens and testosterones mediate associations of phthalates/alternatives with pregnancy and fetal outcomes merits further investigation.PMID:34116379 | DOI:10.1016/j.envint.2021.106676 (Source: Environment International)
Source: Environment International - June 11, 2021 Category: Environmental Health Authors: Diana C Pacyga Joseph C Gardiner Jodi A Flaws Zhong Li Antonia M Calafat Susan A Korrick Susan L Schantz Rita S Strakovsky Source Type: research

Blood lead levels in indigenous peoples living close to oil extraction areas in the Peruvian Amazon
Environ Int. 2021 May 31:106639. doi: 10.1016/j.envint.2021.106639. Online ahead of print.ABSTRACTBACKGROUND: High blood lead levels (BLLs) have been previously reported in indigenous people living in communities in the northern Peruvian Amazon. Oil extraction activities have been conducted in the area since the 1970s and have been identified as a source of lead exposure.OBJECTIVE: Measure BLL and assess risk factors associated with BLL among indigenous populations from four river basins of the northern Peruvian Amazon.METHODS: Participants from 39 communities were selected using a two-stage stratified random selection str...
Source: Environment International - June 9, 2021 Category: Environmental Health Authors: Cristina O'Callaghan-Gordo Jaime Rosales Pilar Liz árraga Frederica Barclay Tami Okamoto Diana M Papoulias Ana Espinosa Mart í Orta-Martinez Manolis Kogevinas John Astete Source Type: research

Blood lead levels in indigenous peoples living close to oil extraction areas in the Peruvian Amazon
Environ Int. 2021 May 31:106639. doi: 10.1016/j.envint.2021.106639. Online ahead of print.ABSTRACTBACKGROUND: High blood lead levels (BLLs) have been previously reported in indigenous people living in communities in the northern Peruvian Amazon. Oil extraction activities have been conducted in the area since the 1970s and have been identified as a source of lead exposure.OBJECTIVE: Measure BLL and assess risk factors associated with BLL among indigenous populations from four river basins of the northern Peruvian Amazon.METHODS: Participants from 39 communities were selected using a two-stage stratified random selection str...
Source: Environment International - June 9, 2021 Category: Environmental Health Authors: Cristina O'Callaghan-Gordo Jaime Rosales Pilar Liz árraga Frederica Barclay Tami Okamoto Diana M Papoulias Ana Espinosa Mart í Orta-Martinez Manolis Kogevinas John Astete Source Type: research

Blood lead levels in indigenous peoples living close to oil extraction areas in the Peruvian Amazon
Environ Int. 2021 May 31:106639. doi: 10.1016/j.envint.2021.106639. Online ahead of print.ABSTRACTBACKGROUND: High blood lead levels (BLLs) have been previously reported in indigenous people living in communities in the northern Peruvian Amazon. Oil extraction activities have been conducted in the area since the 1970s and have been identified as a source of lead exposure.OBJECTIVE: Measure BLL and assess risk factors associated with BLL among indigenous populations from four river basins of the northern Peruvian Amazon.METHODS: Participants from 39 communities were selected using a two-stage stratified random selection str...
Source: Environment International - June 9, 2021 Category: Environmental Health Authors: Cristina O'Callaghan-Gordo Jaime Rosales Pilar Liz árraga Frederica Barclay Tami Okamoto Diana M Papoulias Ana Espinosa Mart í Orta-Martinez Manolis Kogevinas John Astete Source Type: research

Residential airborne culturable fungi under general living scenario: On-site investigation in 12 typical cities, China
CONCLUSIONS: This study reported nation-wide baseline condition of RAF and related influencing factors under general living scenario with quantitative details, which are exceedingly promising for evidence-driven standard and reasonable control strategy of residential airborne culturable in China.PMID:34102580 | DOI:10.1016/j.envint.2021.106669 (Source: Environment International)
Source: Environment International - June 8, 2021 Category: Environmental Health Authors: Lin Fan Jiao Wang Yuyan Yang Wenjing Yang Yuanduo Zhu Yujing Zhang Li Li Xu Li Xu Yan Xiaoyuan Yao Lin Wang Xianliang Wang Source Type: research

Fluoride exposure and children's intelligence: Gene-environment interaction based on SNP-set, gene and pathway analysis, using a case-control design based on a cross-sectional study
Environ Int. 2021 Jun 4;155:106681. doi: 10.1016/j.envint.2021.106681. Online ahead of print.ABSTRACTBACKGROUND: Excessive fluoride exposure has been associated with intelligence loss, but little is known about gene-fluoride interactions on intelligence at SNP-set, gene and pathway level.OBJECTIVES: Here we conducted a population-based study in Chinese school-aged children to estimate the associations of fluoride from internal and external exposures with intelligence as well as to explore the gene-fluoride interactions on intelligence at SNP-set, gene and neurodevelopmental pathway level.METHODS: A total of 952 resident ch...
Source: Environment International - June 7, 2021 Category: Environmental Health Authors: Xingchen Yu Lu Xia Shun Zhang Guoyu Zhou Yonggang Li Hongliang Liu Changchun Hou Qian Zhao Lixin Dong Yushan Cui Qiang Zeng Aiguo Wang Li Liu Source Type: research

Associations between sources of particle number and mortality in four European cities
CONCLUSIONS: We found inconsistent results across cities, sources and lags for associations with natural, CVD, and respiratory mortality.PMID:34098335 | DOI:10.1016/j.envint.2021.106662 (Source: Environment International)
Source: Environment International - June 7, 2021 Category: Environmental Health Authors: Ioar Rivas Laia Vicens Xavier Basaga ña Aurelio Tob ías Klea Katsouyanni Heather Walton Christoph H üglin Andr és Alastuey Markku Kulmala Roy M Harrison Juha Pekkanen Xavier Querol Jordi Sunyer Frank J Kelly Source Type: research

Lipid metabolism disorders associated with dioxin exposure in a cohort of Chinese male workers revealed by a comprehensive lipidomics study
This study aims to explore the serum lipidomic characterization and to understand the underlying mechanisms of adverse health risks associated with dioxin exposure. A lipidomic study integrating nontargeted lipidomics, and targeted free fatty acid (FFA) and acyl-coenzyme A (acyl-CoA) analyses were conducted to investigate the 94 serum samples from two groups of male workers with remarkably different dioxin concentrations. The obtained results exhibited distinct lipidomic signatures between the high and low exposed groups. A total of 37 lipids were identified with the significant changes. The results revealed that dioxin ex...
Source: Environment International - June 7, 2021 Category: Environmental Health Authors: Yanshan Liang Zhi Tang Yousheng Jiang Chunyan Ai Jinling Peng Yuan Liu Jinru Chen Xiong Xin Bo Lei Jianqing Zhang Zongwei Cai Source Type: research

Fluoride exposure and children's intelligence: Gene-environment interaction based on SNP-set, gene and pathway analysis, using a case-control design based on a cross-sectional study
Environ Int. 2021 Jun 4;155:106681. doi: 10.1016/j.envint.2021.106681. Online ahead of print.ABSTRACTBACKGROUND: Excessive fluoride exposure has been associated with intelligence loss, but little is known about gene-fluoride interactions on intelligence at SNP-set, gene and pathway level.OBJECTIVES: Here we conducted a population-based study in Chinese school-aged children to estimate the associations of fluoride from internal and external exposures with intelligence as well as to explore the gene-fluoride interactions on intelligence at SNP-set, gene and neurodevelopmental pathway level.METHODS: A total of 952 resident ch...
Source: Environment International - June 7, 2021 Category: Environmental Health Authors: Xingchen Yu Lu Xia Shun Zhang Guoyu Zhou Yonggang Li Hongliang Liu Changchun Hou Qian Zhao Lixin Dong Yushan Cui Qiang Zeng Aiguo Wang Li Liu Source Type: research

Associations between sources of particle number and mortality in four European cities
CONCLUSIONS: We found inconsistent results across cities, sources and lags for associations with natural, CVD, and respiratory mortality.PMID:34098335 | DOI:10.1016/j.envint.2021.106662 (Source: Environment International)
Source: Environment International - June 7, 2021 Category: Environmental Health Authors: Ioar Rivas Laia Vicens Xavier Basaga ña Aurelio Tob ías Klea Katsouyanni Heather Walton Christoph H üglin Andr és Alastuey Markku Kulmala Roy M Harrison Juha Pekkanen Xavier Querol Jordi Sunyer Frank J Kelly Source Type: research

Lipid metabolism disorders associated with dioxin exposure in a cohort of Chinese male workers revealed by a comprehensive lipidomics study
This study aims to explore the serum lipidomic characterization and to understand the underlying mechanisms of adverse health risks associated with dioxin exposure. A lipidomic study integrating nontargeted lipidomics, and targeted free fatty acid (FFA) and acyl-coenzyme A (acyl-CoA) analyses were conducted to investigate the 94 serum samples from two groups of male workers with remarkably different dioxin concentrations. The obtained results exhibited distinct lipidomic signatures between the high and low exposed groups. A total of 37 lipids were identified with the significant changes. The results revealed that dioxin ex...
Source: Environment International - June 7, 2021 Category: Environmental Health Authors: Yanshan Liang Zhi Tang Yousheng Jiang Chunyan Ai Jinling Peng Yuan Liu Jinru Chen Xiong Xin Bo Lei Jianqing Zhang Zongwei Cai Source Type: research

Prenatal exposure to arsenic and lung function in children from the New Hampshire Birth Cohort Study
Environ Int. 2021 Jun 3;155:106673. doi: 10.1016/j.envint.2021.106673. Online ahead of print.ABSTRACTPrenatal arsenic exposure is associated with an increased risk of lung cancer along with multiple non-carcinogenic outcomes, including respiratory diseases in arsenic-contaminated areas. Limited epidemiologic data exist on whether in utero arsenic exposure influences lung development and subsequent respiratory health. We investigated the association between gestational arsenic exposure and childhood lung function in the New Hampshire Birth Cohort Study. Urinary arsenic speciation including inorganic arsenic (iAs), monomethy...
Source: Environment International - June 6, 2021 Category: Environmental Health Authors: Antonio J Signes-Pastor Pablo Martinez-Camblor Emily Baker Juliette Madan Margaret F Guill Margaret R Karagas Source Type: research

Prenatal exposure to arsenic and lung function in children from the New Hampshire Birth Cohort Study
Environ Int. 2021 Jun 3;155:106673. doi: 10.1016/j.envint.2021.106673. Online ahead of print.ABSTRACTPrenatal arsenic exposure is associated with an increased risk of lung cancer along with multiple non-carcinogenic outcomes, including respiratory diseases in arsenic-contaminated areas. Limited epidemiologic data exist on whether in utero arsenic exposure influences lung development and subsequent respiratory health. We investigated the association between gestational arsenic exposure and childhood lung function in the New Hampshire Birth Cohort Study. Urinary arsenic speciation including inorganic arsenic (iAs), monomethy...
Source: Environment International - June 6, 2021 Category: Environmental Health Authors: Antonio J Signes-Pastor Pablo Martinez-Camblor Emily Baker Juliette Madan Margaret F Guill Margaret R Karagas Source Type: research

Biomonitoring of volatile organic compounds (VOCs) among hairdressers in salons primarily serving women of color: A pilot study
Environ Int. 2021 Jun 2;154:106655. doi: 10.1016/j.envint.2021.106655. Online ahead of print.ABSTRACTHairdressers are exposed to volatile organic compounds (VOCs), many of which have been linked to acute and chronic health effects. Those hairdressers serving an ethnic clientele may potentially experience disproportionate exposures from frequent use of products containing VOCs or different VOC concentrations contained in products which are marketed to the specific needs of their clientele. However, no biomonitoring studies have investigated occupational exposures in this population. In the present pilot study, we sought to ...
Source: Environment International - June 5, 2021 Category: Environmental Health Authors: Lydia M Louis Lucy K Kavi Meleah Boyle Walkiria Pool Deepak Bhandari V íctor R De Jesús Stephen Thomas Anna Z Pollack Angela Sun Seyrona McLean Ana M Rule Lesliam Quir ós-Alcalá Source Type: research

The silver linings of mercury: Reconsideration of its impacts on living organisms from a multi-timescale perspective
Environ Int. 2021 Jun 3;155:106670. doi: 10.1016/j.envint.2021.106670. Online ahead of print.ABSTRACTResearch on mercury (Hg), a naturally occurring element in Earth's lithosphere, has been extremely hot in the past few decades due to the outbreak of a series of disastrous poisoning incidents. However, such studies might provide us a biased view towards Hg if no thorough review about its long-term effects on living organisms from a multi-timescale perspective was performed. Hg might have played a mysterious role in critical intervals (e.g., mass extinction and oceanic anoxia events) in several geologic periods due to the e...
Source: Environment International - June 5, 2021 Category: Environmental Health Authors: Chengjun Li Jun Shen Jin Zhang Pei Lei Yaqi Kong Jichao Zhang Wenli Tang Tianyu Chen Xin Xiang Shuxiao Wang Wei Zhang Huan Zhong Source Type: research

Exposure to nature and mental health outcomes during COVID-19 lockdown. A comparison between Portugal and Spain
CONCLUSION: Exposure to nature was associated with better mental health outcomes during lockdowns, but the natural features associated with improved mental health differed between the two countries. Nature should be incorporated into urban planning interventions and housing design and exposure to nature should be promoted during lockdowns.PMID:34082237 | PMC:PMC8162907 | DOI:10.1016/j.envint.2021.106664 (Source: Environment International)
Source: Environment International - June 3, 2021 Category: Environmental Health Authors: Ana Isabel Ribeiro Margarita Triguero-Mas Cl áudia Jardim Santos Alicia G ómez-Nieto Helen Cole Isabelle Anguelovski Filipa Martins Silva Francesc Bar ó Source Type: research

The impacts of long-term exposure to PM < sub > 2.5 < /sub > on cancer hospitalizations in Brazil
CONCLUSIONS: Long-term exposure to ambient PM2.5 was positively associated with hospitalization for many cancer types in Brazil. Inpatient days and cost would be saved if the annual PM2.5 exposure was reduced.PMID:34082238 | DOI:10.1016/j.envint.2021.106671 (Source: Environment International)
Source: Environment International - June 3, 2021 Category: Environmental Health Authors: Pei Yu Rongbin Xu Micheline S Z S Coelho Paulo H N Saldiva Shanshan Li Qi Zhao Ajay Mahal Malcolm Sim Michael J Abramson Yuming Guo Source Type: research

A new insight into the role of aryl hydrocarbon receptor (AhR) in the migration of glioblastoma by AhR-IL24 axis regulation
This study demonstrated that AhR plays important roles in regulating the migration of glioblastoma, and the induction of the AhR-IL24 axis mediates the inhibition of migration in response to TCDD or FICZ treatment.PMID:34082239 | DOI:10.1016/j.envint.2021.106658 (Source: Environment International)
Source: Environment International - June 3, 2021 Category: Environmental Health Authors: Yiyun Liu Yangsheng Chen Rui Sha Yunping Li Tong Xu Xiaoxu Hu Li Xu Qunhui Xie Bin Zhao Source Type: research

Background exposure to polychlorinated biphenyls and all-cause, cancer-specific, and cardiovascular-specific mortality: A systematic review and meta-analysis
CONCLUSION: Our meta-analysis suggests that background exposure to PCBs is associated with an increased risk of cardiovascular-specific mortality in the general population with a "moderate" level of evidence. These findings should be interpreted with caution given the small number of studies on mortality in the general population.PMID:34082240 | DOI:10.1016/j.envint.2021.106663 (Source: Environment International)
Source: Environment International - June 3, 2021 Category: Environmental Health Authors: Thibault Fiolet Yahya Mahamat-Saleh Pauline Frenoy Marina Kvaskoff Francesca Romana Mancini Source Type: research

Exposure to nature and mental health outcomes during COVID-19 lockdown. A comparison between Portugal and Spain
CONCLUSION: Exposure to nature was associated with better mental health outcomes during lockdowns, but the natural features associated with improved mental health differed between the two countries. Nature should be incorporated into urban planning interventions and housing design and exposure to nature should be promoted during lockdowns.PMID:34082237 | PMC:PMC8162907 | DOI:10.1016/j.envint.2021.106664 (Source: Environment International)
Source: Environment International - June 3, 2021 Category: Environmental Health Authors: Ana Isabel Ribeiro Margarita Triguero-Mas Cl áudia Jardim Santos Alicia G ómez-Nieto Helen Cole Isabelle Anguelovski Filipa Martins Silva Francesc Bar ó Source Type: research

The impacts of long-term exposure to PM < sub > 2.5 < /sub > on cancer hospitalizations in Brazil
CONCLUSIONS: Long-term exposure to ambient PM2.5 was positively associated with hospitalization for many cancer types in Brazil. Inpatient days and cost would be saved if the annual PM2.5 exposure was reduced.PMID:34082238 | DOI:10.1016/j.envint.2021.106671 (Source: Environment International)
Source: Environment International - June 3, 2021 Category: Environmental Health Authors: Pei Yu Rongbin Xu Micheline S Z S Coelho Paulo H N Saldiva Shanshan Li Qi Zhao Ajay Mahal Malcolm Sim Michael J Abramson Yuming Guo Source Type: research

A new insight into the role of aryl hydrocarbon receptor (AhR) in the migration of glioblastoma by AhR-IL24 axis regulation
This study demonstrated that AhR plays important roles in regulating the migration of glioblastoma, and the induction of the AhR-IL24 axis mediates the inhibition of migration in response to TCDD or FICZ treatment.PMID:34082239 | DOI:10.1016/j.envint.2021.106658 (Source: Environment International)
Source: Environment International - June 3, 2021 Category: Environmental Health Authors: Yiyun Liu Yangsheng Chen Rui Sha Yunping Li Tong Xu Xiaoxu Hu Li Xu Qunhui Xie Bin Zhao Source Type: research

Background exposure to polychlorinated biphenyls and all-cause, cancer-specific, and cardiovascular-specific mortality: A systematic review and meta-analysis
CONCLUSION: Our meta-analysis suggests that background exposure to PCBs is associated with an increased risk of cardiovascular-specific mortality in the general population with a "moderate" level of evidence. These findings should be interpreted with caution given the small number of studies on mortality in the general population.PMID:34082240 | DOI:10.1016/j.envint.2021.106663 (Source: Environment International)
Source: Environment International - June 3, 2021 Category: Environmental Health Authors: Thibault Fiolet Yahya Mahamat-Saleh Pauline Frenoy Marina Kvaskoff Francesca Romana Mancini Source Type: research

Exposure to nature and mental health outcomes during COVID-19 lockdown. A comparison between Portugal and Spain
CONCLUSION: Exposure to nature was associated with better mental health outcomes during lockdowns, but the natural features associated with improved mental health differed between the two countries. Nature should be incorporated into urban planning interventions and housing design and exposure to nature should be promoted during lockdowns.PMID:34082237 | DOI:10.1016/j.envint.2021.106664 (Source: Environment International)
Source: Environment International - June 3, 2021 Category: Environmental Health Authors: Ana Isabel Ribeiro Margarita Triguero-Mas Cl áudia Jardim Santos Alicia G ómez-Nieto Helen Cole Isabelle Anguelovski Filipa Martins Silva Francesc Bar ó Source Type: research

The impacts of long-term exposure to PM < sub > 2.5 < /sub > on cancer hospitalizations in Brazil
CONCLUSIONS: Long-term exposure to ambient PM2.5 was positively associated with hospitalization for many cancer types in Brazil. Inpatient days and cost would be saved if the annual PM2.5 exposure was reduced.PMID:34082238 | DOI:10.1016/j.envint.2021.106671 (Source: Environment International)
Source: Environment International - June 3, 2021 Category: Environmental Health Authors: Pei Yu Rongbin Xu Micheline S Z S Coelho Paulo H N Saldiva Shanshan Li Qi Zhao Ajay Mahal Malcolm Sim Michael J Abramson Yuming Guo Source Type: research

A new insight into the role of aryl hydrocarbon receptor (AhR) in the migration of glioblastoma by AhR-IL24 axis regulation
This study demonstrated that AhR plays important roles in regulating the migration of glioblastoma, and the induction of the AhR-IL24 axis mediates the inhibition of migration in response to TCDD or FICZ treatment.PMID:34082239 | DOI:10.1016/j.envint.2021.106658 (Source: Environment International)
Source: Environment International - June 3, 2021 Category: Environmental Health Authors: Yiyun Liu Yangsheng Chen Rui Sha Yunping Li Tong Xu Xiaoxu Hu Li Xu Qunhui Xie Bin Zhao Source Type: research

Background exposure to polychlorinated biphenyls and all-cause, cancer-specific, and cardiovascular-specific mortality: A systematic review and meta-analysis
CONCLUSION: Our meta-analysis suggests that background exposure to PCBs is associated with an increased risk of cardiovascular-specific mortality in the general population with a "moderate" level of evidence. These findings should be interpreted with caution given the small number of studies on mortality in the general population.PMID:34082240 | DOI:10.1016/j.envint.2021.106663 (Source: Environment International)
Source: Environment International - June 3, 2021 Category: Environmental Health Authors: Thibault Fiolet Yahya Mahamat-Saleh Pauline Frenoy Marina Kvaskoff Francesca Romana Mancini Source Type: research

Advances in the toxicology research of microcystins based on Omics approaches
Environ Int. 2021 May 30;154:106661. doi: 10.1016/j.envint.2021.106661. Online ahead of print.ABSTRACTMicrocystins (MCs) are the most widely distributed cyanotoxins, which can be ingested by animals and human body in multiple ways, resulting in a threat to human health and the biodiversity of wildlife. Therefore, the study on toxic effects and mechanisms of MCs is one of the focuses of attention. Recently, the Omics techniques, i.e. genomics, transcriptomics, proteomics and metabolomics, have significantly contributed to the comprehensive understanding and revealing of the molecular mechanisms about the toxicity of MCs. Th...
Source: Environment International - June 2, 2021 Category: Environmental Health Authors: Ya Ma Haohao Liu Xingde Du Ziang Shi Xiaohui Liu Rui Wang Shiyu Zhang Zhihui Tian Linjia Shi Hongxiang Guo Huizhen Zhang Source Type: research

Early childhood exposure to ambient air pollution is associated with increased risk of paediatric asthma: An administrative cohort study from Stockholm, Sweden
CONCLUSION: Our results suggest that exposure to air pollution during the first three years of life may increase the risk for asthma in early childhood. The findings further imply a possible increased vulnerability to air pollution-attributed asthma among low SES children.PMID:34077855 | DOI:10.1016/j.envint.2021.106667 (Source: Environment International)
Source: Environment International - June 2, 2021 Category: Environmental Health Authors: David Olsson Bertil Forsberg Lennart Br åbäck Camilla Geels J ørgen Brandt Jesper H Christensen Lise M Frohn Anna Oudin Source Type: research

Urinary specific gravity measures in the U.S. population: Implications for the adjustment of non-persistent chemical urinary biomarker data
DISCUSSION: Specific gravity, like creatinine, is associated with sociodemographic and body composition variables. Accounting for these factors as part of the dilution correction method may be important to minimize bias.PMID:34062395 | DOI:10.1016/j.envint.2021.106656 (Source: Environment International)
Source: Environment International - June 1, 2021 Category: Environmental Health Authors: Jordan R Kuiper Katie M O'Brien Kelly K Ferguson Jessie P Buckley Source Type: research

Assessment of internal exposure to methylsiloxanes in children and associated non-dietary exposure risk
In this study, we assessed internal exposure doses and external exposure levels of MSs in children from industrial and residential areas in southwestern China. Indoor air, indoor dust, and personal care product (PCP) samples were collected to evaluate indoor non-dietary MSs exposure in children through various pathways. The concentrations of MSs in indoor environments of industrial areas were approximately one to four orders of magnitude higher than those of residential areas. Sun protection products contained the highest concentrations of MSs. Relatively high levels of cyclic methylsiloxanes (CMSs) were found in plasma of...
Source: Environment International - June 1, 2021 Category: Environmental Health Authors: Junyu Guo Ying Zhou Yifei Wang Boya Zhang Jianbo Zhang Source Type: research