Independent association of vitamin D and insulin resistance in obstructive sleep apnea.
Abstract BACKGROUND: Vitamin D insufficiency and/or high levels of parathyroid hormone (PTH) seem to be associated with abnormal glucose metabolism, which is frequent in obstructive sleep apnea (OSA). The purpose of this study was to investigate vitamin D and PTH concentrations in OSA, and to explore potential links between vitamin D, PTH and insulin resistance (IR). METHODS: A total of 112 subjects with suspected OSA were recruited consecutively, and evaluated by polysomnography (PSG) to determine the number of apnea and hypopnea episodes per hour of sleep (apnea/hypopnea index: AHI). OSA...
Source: Annales d'Endocrinologie - November 1, 2019 Category: Endocrinology Authors: Fan Z, Cao B, Long H, Feng L, Li Q, Zhang Y, Li T Tags: Ann Endocrinol (Paris) Source Type: research

Adrenocortical carcinoma: Impact of surgical treatment.
amy A Abstract Compared to benign adrenal lesions, secreting or otherwise, malignant adrenocortical carcinoma is rare. Overall prognosis is poor, with
Source: Annales d'Endocrinologie - October 18, 2019 Category: Endocrinology Authors: Mirallié E, Blanchard C, Caillard C, Rodien P, Briet C, Mucci S, Drui D, Hamy A Tags: Ann Endocrinol (Paris) Source Type: research

Can incomplete adrenal venous sampling data be used in predicting the subtype of primary aldosteronism?
CONCLUSION: The diagnostic model in this study contributes to clinical decision-making in patients with only partial PA with incomplete AVS data. PMID: 31722788 [PubMed - as supplied by publisher] (Source: Annales d'Endocrinologie)
Source: Annales d'Endocrinologie - October 18, 2019 Category: Endocrinology Authors: Lin L, Zhou L, Guo Y, Liu Z, Chen T, Liu Z, Wang K, Li J, Zhu Y, Ren Y Tags: Ann Endocrinol (Paris) Source Type: research

Metallothionein protein and minichromosome maintenance protein-2 expression in adrenocortical tumors.
Abstract AIM: Some resected adrenal-confined adrenocortical carcinomas metastasize and others not. The present study was designed to evaluate the expression of metallothionein protein (MT) and minichromosome maintenance protein-2 (MCM2) in adrenocortical carcinomas and adrenocortical adenomas, and to test the correlation between this and adrenocortical carcinoma aggressiveness. MATERIALS AND METHODS: The study comprised 14 patients operated on for adrenocortical carcinoma, 15 operated on for adrenocortical adenoma and 2 with normal adrenals. Hematoxylin-eosin staining was used for histological ...
Source: Annales d'Endocrinologie - October 18, 2019 Category: Endocrinology Authors: Saiegh L, Sheikh-Ahmad M, Shechner C, Reut M, Darawsha Y, Zolotov S, Shefer H, Bejar I, Bejar J Tags: Ann Endocrinol (Paris) Source Type: research

When Graves' disease resists to surgery: A rare case of an association with follicular thyroid cancer in struma ovarii.
PMID: 31708080 [PubMed - as supplied by publisher] (Source: Annales d'Endocrinologie)
Source: Annales d'Endocrinologie - October 18, 2019 Category: Endocrinology Authors: Richa C, Quilhot P, Uzan C, Buffet C, Lussey-Lepoutre C Tags: Ann Endocrinol (Paris) Source Type: research

Insuffisance surr énalienne secondaire : actualités diagnostiques et thérapeutiques: News in diagnosis and therapeutics of secondary adrenal insufficiency.
Insuffisance surrénalienne secondaire : actualités diagnostiques et thérapeutiques: News in diagnosis and therapeutics of secondary adrenal insufficiency. Ann Endocrinol (Paris). 2019 Sep;80 Suppl 1:S1-S9 Authors: Vinolas H, Lombès M, Tabarin A Abstract Immunotherapy and opioids treatment are new causes of secondary adrenal insufficiency (SAI). Prevalence of SAI with immunotherapy is more frequent with combined therapy (8% vs 4 to 10% with CTLA4 blocking antibody and 1% with PD1 blocking antibody). Although hypophysitis are more frequently observed with CTLA4 blocking antib...
Source: Annales d'Endocrinologie - September 1, 2019 Category: Endocrinology Authors: Vinolas H, Lombès M, Tabarin A Tags: Ann Endocrinol (Paris) Source Type: research

Acrom égalie : améliorer la prise en charge: Acromegaly: improving care.
Acromégalie : améliorer la prise en charge: Acromegaly: improving care. Ann Endocrinol (Paris). 2019 Sep;80 Suppl 1:S10-S18 Authors: Mosbah H, Brue T, Chanson P Abstract Acromegaly is characterized by increased release of growth hormone (GH) and, consequently, Insulin-Like Growth Factor I (IGF-I), most often by a pituitary adenoma. Prolonged exposure to excess hormone leads to progressive somatic disfigurement and a wide range of systemic manifestations that are associated with increased mortality. Transsphenoidal adenomectomy is the treatment of choice of GH-secreting pituitary tumors b...
Source: Annales d'Endocrinologie - September 1, 2019 Category: Endocrinology Authors: Mosbah H, Brue T, Chanson P Tags: Ann Endocrinol (Paris) Source Type: research

La n éoplasie endocrinienne multiple de type 1 : mise au point après le congrès de l’ENETS 2019: Multiple Endocrine Neoplasia Type 1: Development after the ENETS 2019 Congress.
La néoplasie endocrinienne multiple de type 1 : mise au point après le congrès de l’ENETS 2019: Multiple Endocrine Neoplasia Type 1: Development after the ENETS 2019 Congress. Ann Endocrinol (Paris). 2019 Sep;80 Suppl 1:S19-S28 Authors: Vialon M, Desailloud R, Caron P Abstract Multiple Endocrine Neoplasia Type 1 (NEM1) is related to mutations of the menin gene. It is an autosomal dominant disease. Its prevalence is about 1/30 000 with a hugh penetrance. There is no genotype-phenotype correlation. This hereditary syndrome is characterized by the presence of tumors of the endo...
Source: Annales d'Endocrinologie - September 1, 2019 Category: Endocrinology Authors: Vialon M, Desailloud R, Caron P Tags: Ann Endocrinol (Paris) Source Type: research

Le syndrome des ovaires polykystiques : quelles nouveaut és en 2019 ?: Keeping up with PCOS in 2019.
Le syndrome des ovaires polykystiques : quelles nouveautés en 2019 ?: Keeping up with PCOS in 2019. Ann Endocrinol (Paris). 2019 Sep;80 Suppl 1:S29-S37 Authors: Gourbesville C, Kerlan V, Reznik Y Abstract PolyCystic Ovary Syndrome (PCOS) is the first endocrinopathy of women of child-bearing age and the leading cause of anovulatory infertility. The pathophysiology of this syndrome is complex and involves genetic traits highlighted by GWAS and epigenetic traits with DNA methylation modifications. Initially described as an ovarian disease, works carried out over recent years were turned towards ne...
Source: Annales d'Endocrinologie - September 1, 2019 Category: Endocrinology Authors: Gourbesville C, Kerlan V, Reznik Y Tags: Ann Endocrinol (Paris) Source Type: research

Weight-loss with activation of brown fat: Suspect pheochromocytoma.
CONCLUSION: Brown fat activation may mislead diagnosis of pheochromocytoma, suggesting multi-metastatic extra-adrenal tumor, if clinicians are not aware of it. PMID: 31606198 [PubMed - as supplied by publisher] (Source: Annales d'Endocrinologie)
Source: Annales d'Endocrinologie - July 26, 2019 Category: Endocrinology Authors: Geslot A, Bennet A, Hitzel A, Thoulouzan M, Mouly C, Savagner F, Quintyn-Ranty ML, Caron P, Vezzosi D Tags: Ann Endocrinol (Paris) Source Type: research

TSH inhibits eNOS expression in HMEC-1 cells through the TSHR/PI3K/AKT signaling pathway.
Abstract OBJECTIVE: To investigate the effects of thyroid-stimulating hormone (TSH) on the expression of endothelial nitric oxide synthase (eNOS) in human microvascular endothelial cells (HMEC-1) and explore the potential mechanism. MATERIALS AND METHODS: Expression of thyroid-stimulating hormone receptor (TSHR) in HMEC-1 cells was determined by immunofluorescence, reverse transcription-polymerase chain reaction (RT-PCR), and Western blotting. Cell proliferation and the production of nitric oxide (NO) and superoxide anion (SA) were measured after TSH treatment. eNOS expression and AKT phosphorylation were det...
Source: Annales d'Endocrinologie - July 26, 2019 Category: Endocrinology Authors: Chen J, Shi M, Wang N, Yi P, Sun L, Meng Q Tags: Ann Endocrinol (Paris) Source Type: research

Apparent resistance to thyroid hormones: From biological interference to genetics.
Abstract Resistance to thyroid hormones syndrome is defined as increased thyroxine (T4) and triiodothyronine (T3) concentrations associated with normal or sometimes increased thyrotropin (TSH) concentration. This is usually due to a pathogenic variant with loss of function of the gene coding for thyroid hormone receptor β (THRB). This discrepancy in thyroid hormones (TH) and TSH concentrations is also frequently observed in the presence of analytical interference, notably alteration of TH transport proteins in serum. During 2017, 58 samples were sent to our laboratory in the Angers University Hospit...
Source: Annales d'Endocrinologie - July 26, 2019 Category: Endocrinology Authors: Dieu X, Sueur G, Moal V, Boux de Casson F, Bouzamondo N, Bouhours N, Briet C, Illouz F, Reynier P, Coutant R, Rodien P, Mirebeau-Prunier D Tags: Ann Endocrinol (Paris) Source Type: research

Sphingosine-1-phosphate (S1P) in ovarian physiology and disease.
ez D, Rosales-Torres AM Abstract Sphingosine-1-phoshate (S1P) is a membrane sphingolipid involved in several physiological processes, including cell proliferation, tissue growth, cell survival and migration, inflammation, vasculogenesis, and angiogenesis. Herein, we review the most critical effects of S1P on ovarian function, including its physiological and pathophysiological effects. Based on the available evidence, S1P plays an important role in ovarian physiology, participating as an essential stimulator of follicular development in both the preantral and antral phases, as well as in ovulation and corpus luteum...
Source: Annales d'Endocrinologie - July 26, 2019 Category: Endocrinology Authors: Hernández-Coronado CG, Guzmán A, Castillo-Juárez H, Zamora-Gutiérrez D, Rosales-Torres AM Tags: Ann Endocrinol (Paris) Source Type: research

Feasibility criteria for total thyroidectomy in outpatient surgery.
CONCLUSION: Surgery time, female gender, repeated dissection and total thyroidectomy for benign adenoma are risk factors that should be considered in decision-making for performing TT on an outpatient basis. PMID: 31400860 [PubMed - as supplied by publisher] (Source: Annales d'Endocrinologie)
Source: Annales d'Endocrinologie - July 26, 2019 Category: Endocrinology Authors: Philippe JB, Riou J, Lemoult A, Sarfati-Lebreton M, Hamy A, Mucci S Tags: Ann Endocrinol (Paris) Source Type: research

Diagnosis, pathology, and management of TSH-secreting pituitary tumors. A single-center retrospective study of 20  patients from 1981 to 2014.
The objective of this study was to describe initial presentation and follow-up in patients presenting TSH-secreting tumors and to characterize the pathological features, based on a cohort of 20 patients treated in our referral center, between 1981 and 2014. Most of the patients (75%) were female, aged around 50 years (mean: 50±13 years). Initial symptoms were hyperthyroidism (8/20) and/or tumor mass-related symptoms. Median time to diagnosis was 18 months. Biochemical hyperthyroidism was found in 15 patients. Most of the tumors were macroadenomas (75%) and 30% were invasive. Seventeen patien...
Source: Annales d'Endocrinologie - July 26, 2019 Category: Endocrinology Authors: Căpraru OM, Gaillard C, Vasiljevic A, Lasolle H, Borson-Chazot F, Raverot V, Jouanneau E, Trouillas J, Raverot G Tags: Ann Endocrinol (Paris) Source Type: research

Micropapillary carcinoma: Description and rise in incidence in the French Marne-Ardennes thyroid cancer registry.
Abstract CONTEXT: Yearly incidence of thyroid cancer has nearly tripled in the past four decades, due to improvements in and better use of diagnostic procedures, enabling detection of smaller tumors, and notably micropapillary carcinoma (MPC: ≤10 mm). OBJECTIVES: The aim of our study was to confirm increasing incidence, to describe the characteristics and circumstances of discovery, and to examine the reasons for this rise in incidence of MPCs, based on the French Marne-Ardennes registry for 1975-2014. DESIGN: This was a retrospective observational cohort study. RESULTS: Two thousand six hun...
Source: Annales d'Endocrinologie - July 8, 2019 Category: Endocrinology Authors: Zalzali M, Debreuve A, Richard C, Filieri C, Schvartz C Tags: Ann Endocrinol (Paris) Source Type: research

Cardiothyreosis: Prevalence and risk factors.
CONCLUSIONS: The prevalence of CT in patients with overt hyperthyroidism was relatively low. Cardiac complications were AF and CHF with a clear predominance of AF. Advanced age was the only independent risk factor of CT. Cardiac complications may be seen even if hyperthyroidism is not biologically severe. PMID: 31235068 [PubMed - as supplied by publisher] (Source: Annales d'Endocrinologie)
Source: Annales d'Endocrinologie - June 21, 2019 Category: Endocrinology Authors: Yazidi M, Chihaoui M, Oueslati H, Chaker F, Rjeb O, Rjaibi S, Ouali S, Slimane H Tags: Ann Endocrinol (Paris) Source Type: research

New insights into the pathophysiology and treatment of neuroendocrine tumors.
PMID: 31153387 [PubMed - in process] (Source: Annales d'Endocrinologie)
Source: Annales d'Endocrinologie - June 1, 2019 Category: Endocrinology Authors: Persani L, Scientific Committee of the Klotz Days 2019 Tags: Ann Endocrinol (Paris) Source Type: research

French and European Neuroendocrine Tumor Society consensus guidelines.
PMID: 31097196 [PubMed - as supplied by publisher] (Source: Annales d'Endocrinologie)
Source: Annales d'Endocrinologie - April 11, 2019 Category: Endocrinology Authors: Cadiot G Tags: Ann Endocrinol (Paris) Source Type: research

Update on phenotypes of MEN1 mutation carriers.
PMID: 31088683 [PubMed - as supplied by publisher] (Source: Annales d'Endocrinologie)
Source: Annales d'Endocrinologie - April 11, 2019 Category: Endocrinology Authors: Valk GD Tags: Ann Endocrinol (Paris) Source Type: research

Gastroenteropancreatic neuroendocrine tumors: Role of surgery.
Abstract Natural history of gastroenteropancreatic (GEP) Neuroendocrine tumors (NETs) is better and better known so indications of surgery are presently selective. Surgical resection, but also endoscopic resection and observation, can be proposed for gastric NETs according to presentation, size and grade. For small bowel NETs, resection is frequently needed but should obtain the best compromise between radicality and postoperative functional disorders. Appendiceal NETs are frequently diagnosed by appendectomy for appendicitis, but some patients at high risk for lymph node metastasis and recurrence should be reoper...
Source: Annales d'Endocrinologie - April 11, 2019 Category: Endocrinology Authors: Sauvanet A Tags: Ann Endocrinol (Paris) Source Type: research

The landscape of molecular alterations in pancreatic and small intestinal neuroendocrine tumours.
Abstract Gastroenteropancreatic Neuroendocrine Neoplasms (GEP-NENs) arise throughout the gut and feature varying biological behaviour and malignant potential. GEP-NENs include two genetically different entities, well-differentiated neuroendocrine tumours (NETs) and poorly differentiated neuroendocrine carcinomas (NEC). NECs are characterized by a dismal prognosis and by distinctive TP53 and RB1 inactivation which sets them apart from NETs. The latter, conversely, have a wide spectrum of aggressiveness and molecular alterations. Knowledge on their biology has recently expanded thanks to high-throughput studies focu...
Source: Annales d'Endocrinologie - April 11, 2019 Category: Endocrinology Authors: Scarpa A Tags: Ann Endocrinol (Paris) Source Type: research

Lung and digestive neuroendocrine neoplasms. From WHO classification to biomarker screening: Which perspectives?
Abstract The recent classifications of lung and digestive neuroendocrine neoplasms (NENs) make a fundamental distinction between well- and poorly-differentiated neoplasms. Well-differentiated NENs are termed carcinoids in the lung and neuroendocrine tumors in the gastroenteropancreatic sphere; their risk of malignancy is highly variable; histological grading is used to stratify patients into prognostically significant groups. Poorly-differentiated NENs are termed neuroendocrine carcinoma in both the lung and the digestive sphere; they constantly are of high grade of malignancy; two types are recognized on the basi...
Source: Annales d'Endocrinologie - April 11, 2019 Category: Endocrinology Authors: Scoazec JY Tags: Ann Endocrinol (Paris) Source Type: research

Aggressive gastro-entero-pancreatic neoplasms.
PMID: 31064660 [PubMed - as supplied by publisher] (Source: Annales d'Endocrinologie)
Source: Annales d'Endocrinologie - April 11, 2019 Category: Endocrinology Authors: Coriat R Tags: Ann Endocrinol (Paris) Source Type: research

Transplantable zebrafish models of neuroendocrine tumors.
Abstract Neuroendocrine tumors (NETs) are rare neoplasms whose incidence is increasing. NETs constitute a heterogeneous group of tumors. Their clinical features, functional properties, and clinical course are different on the basis of their site of origin. Due to the heterogeneity of these tumors, a coordinated multidisciplinary approach is required in these patients. However, medical doctor encounters many difficulties when providing care for patients with NETs. This review provides an overview of the state of the art of zebrafish model in the cancer research with a main focus on NETs. PMID: 31064661 [PubMed...
Source: Annales d'Endocrinologie - April 11, 2019 Category: Endocrinology Authors: Gaudenzi G, Vitale G Tags: Ann Endocrinol (Paris) Source Type: research

Digestive system mixed neuroendocrine-non-neuroendocrine neoplasms (MiNEN).
PMID: 31064662 [PubMed - as supplied by publisher] (Source: Annales d'Endocrinologie)
Source: Annales d'Endocrinologie - April 11, 2019 Category: Endocrinology Authors: de Mestier L, Cros J Tags: Ann Endocrinol (Paris) Source Type: research

Receptor radionuclide targeting for neuroendocrine tumors (NET) diagnostic and therapy.
Abstract Neuroendocrine tumors (NET) represent a heterogeneous group of tumors originating from cells of neuroendocrine origin, which express somatostatin receptors (SSTR). This property allowed the successful development of radionuclides for diagnostic and peptide radionuclide radiation therapy (PRRT). This is the paradigm for the theragnostic concept in NET personalized medicine. The only phase III study to date (NETTER-1) clearly demonstrated the ability of 177Lutetium-based PRRT to improve progression-free survival in advanced intestinal NETs. In clinical practice, the indications are limited to G1-G2 well-dif...
Source: Annales d'Endocrinologie - April 11, 2019 Category: Endocrinology Authors: Vija L, Dierickx L, Courbon F Tags: Ann Endocrinol (Paris) Source Type: research

Emerging molecular markers of metastatic pheochromocytomas and paragangliomas.
Abstract Metastatic pheochromocytoma/paraganglioma (PPGL) represents a major clinical challenge due to limitations in accurate diagnostic tools and effective treatments. Currently, patients classified at high-risk by means of clinical, biochemical and genetic criteria, require a lifelong monitoring, while it remains difficult to determine the metastatic potential of PPGL only on the basis of histopathological features. Thus, tumor molecular markers that improve the risk stratification of these patients are needed. In the past few years, we have witnessed an unprecedented molecular characterization of PPGL, which l...
Source: Annales d'Endocrinologie - April 11, 2019 Category: Endocrinology Authors: Goncalves J, Lussey-Lepoutre C, Favier J, Gimenez-Roqueplo AP, Castro-Vega LJ Tags: Ann Endocrinol (Paris) Source Type: research

Baseline and stimulated calcitonin: Thresholds for the diagnosis of medullary thyroid cancer.
PMID: 31053250 [PubMed - as supplied by publisher] (Source: Annales d'Endocrinologie)
Source: Annales d'Endocrinologie - April 11, 2019 Category: Endocrinology Authors: Fugazzola L Tags: Ann Endocrinol (Paris) Source Type: research

Clinical utility of genetic diagnosis for sporadic and hereditary medullary thyroid carcinoma.
In conclusions RET genetic screening allows the identification of the hereditary/sporadic nature of MTC and of a relevant percentage of hidden familial MTC. Furthermore, it favors the early diagnosis of MTC in RET positive subjects. RET positive patients and no clinical evidence of MTC can be followed and surgical treatment can be delayed. Finally RET negative relatives do not need to be further monitored. PMID: 31053251 [PubMed - as supplied by publisher] (Source: Annales d'Endocrinologie)
Source: Annales d'Endocrinologie - April 11, 2019 Category: Endocrinology Authors: Elisei R, Bottici V, Cappagli V, Ramone T, Tacito A, Ciampi R, Romei C Tags: Ann Endocrinol (Paris) Source Type: research

Endoscopic ultrasound-guided radiofrequency ablation for pancreatic neuroendocrine tumor.
PMID: 31053252 [PubMed - as supplied by publisher] (Source: Annales d'Endocrinologie)
Source: Annales d'Endocrinologie - April 11, 2019 Category: Endocrinology Authors: Barthet M Tags: Ann Endocrinol (Paris) Source Type: research

Relevance of neuroendocrine tumours models assessed by kinomic profiling.
Abstract Although there is evidence of a significant rise of neuroendocrine tumours (NETs) incidence, current treatments are largely insufficient due to somewhat poor knowledge of these tumours. Despite many efforts achieved to expose driver oncogene mutations in NETs, the genetic landscape of NETs is characterized by relatively few mutations and chromosomal aberrations per tumour compared with other tumour types. In addition, NETs display few actionable mutations providing compelling rationale for targeted therapies. Recent works aiming at characterizing currently used NETs in vitro models at the genomic level ra...
Source: Annales d'Endocrinologie - April 11, 2019 Category: Endocrinology Authors: Romano D Tags: Ann Endocrinol (Paris) Source Type: research

Efficacy and tolerance of recombinant growth hormone treatment in children with growth retardation related to long-term glucocorticosteroid therapy.
Abstract OBJECTIVE: To evaluate tolerance and efficacy of recombinant human growth hormone treatment in children on long-term glucocorticoid therapy. METHODS: A 5-year prospective open-label study included children on glucocorticoid therapy with bone age
Source: Annales d'Endocrinologie - March 4, 2019 Category: Endocrinology Authors: Basmaison O, Ranchin B, Zouater H, Robertson A, Gomez R, Koppiker N Tags: Ann Endocrinol (Paris) Source Type: research

Graves' disease as a first autoimmune manifestation of a stiff person syndrome.
PMID: 30846197 [PubMed - as supplied by publisher] (Source: Annales d'Endocrinologie)
Source: Annales d'Endocrinologie - February 14, 2019 Category: Endocrinology Authors: Servais T, London F, Donckier JE Tags: Ann Endocrinol (Paris) Source Type: research

Circulating Vascular Cell Adhesion Molecule-1 (VCAM-1) and Intercellular Adhesion Molecule-1 (ICAM-1): Relationship with carotid artery elasticity in patients with impaired glucose regulation (IGR).
Abstract OBJECTIVE: To investigate the relations of circulating adhesion molecule vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) with carotid artery elasticity in patients with impaired glucose regulation (IGR). METHODS: A total of 208 subjects were enrolled from January 2013 to March 2014. One hundred forty-eight were IGR patients, and 60 had normal glucose tolerance (NGT). Carotid intima-media thickness (IMT), carotid artery pressure-strain elasticity coefficient (Eρ), stiffness (β), arterial compliance (AC), and pulse wave velocity (PWVβ), ...
Source: Annales d'Endocrinologie - February 7, 2019 Category: Endocrinology Authors: Wang TT, Wang XM, Zhang XL Tags: Ann Endocrinol (Paris) Source Type: research

Functioning gonadotroph adenoma with severe ovarian hyperstimulation syndrome: A new emergency in pituitary adenoma surgery? Surgical considerations and literature review.
Abstract The authors reported 2 cases of functioning gonadotroph pituitary adenoma (FGPA) revealed by an ovarian hyperstimulation syndrome (OHSS) in young women. In the first case, OHSS was observed after GnRH analog injection. Pelvic echography revealed multiple voluminous ovarian cysts. Dopamine agonist posology failed in estradiol hypersecretion control, which necessitated endoscopic endonasal transsphenoidal surgery. The patient experienced improvement in pelvic pain as estradiol hypersecretion decreased during the first few postoperative days. Outcome was favorable, and her menstrual cycle was normal aft...
Source: Annales d'Endocrinologie - February 7, 2019 Category: Endocrinology Authors: Graillon T, Castinetti F, Chabert-Orsini V, Morange I, Cuny T, Albarel F, Brue T, Dufour H Tags: Ann Endocrinol (Paris) Source Type: research

Case report: Ectopic ACTH secretion due to a metastatic atypical lung carcinoid tumor. From diagnosis to treatment.
PMID: 30739712 [PubMed - as supplied by publisher] (Source: Annales d'Endocrinologie)
Source: Annales d'Endocrinologie - January 29, 2019 Category: Endocrinology Authors: Hoornaert E, Jacqmin L, Montfort L, Maiter D, Derdelinckx L Tags: Ann Endocrinol (Paris) Source Type: research

Letter to the editor: A case of laboratory-generated "thyroid dysfunction".
Letter to the editor: A case of laboratory-generated "thyroid dysfunction". Ann Endocrinol (Paris). 2018 Oct 31;: Authors: Raverot V, Bordeau É, Periot C, Perrin P, Chardon L, Plotton I, Nouvel M, Lapoirie M, Borson-Chazot F PMID: 30685059 [PubMed - as supplied by publisher] (Source: Annales d'Endocrinologie)
Source: Annales d'Endocrinologie - October 31, 2018 Category: Endocrinology Authors: Raverot V, Bordeau É, Periot C, Perrin P, Chardon L, Plotton I, Nouvel M, Lapoirie M, Borson-Chazot F Tags: Ann Endocrinol (Paris) Source Type: research

Primary adrenal insufficiency and hemochromatosis  - Cause and effect relationship or a coincidence?
Primary adrenal insufficiency and hemochromatosis - Cause and effect relationship or a coincidence? Ann Endocrinol (Paris). 2018 Oct 16;: Authors: Banaszkiewicz K, Sikorska K, Dorniak K, Lewczuk-Myślicka A, Sworczak K, Szurowska E, Sabisz A, Glińska A PMID: 30340758 [PubMed - as supplied by publisher] (Source: Annales d'Endocrinologie)
Source: Annales d'Endocrinologie - October 16, 2018 Category: Endocrinology Authors: Banaszkiewicz K, Sikorska K, Dorniak K, Lewczuk-Myślicka A, Sworczak K, Szurowska E, Sabisz A, Glińska A Tags: Ann Endocrinol (Paris) Source Type: research

Pasireotide: A potential therapeutic alternative for resistant prolactinoma.
CONCLUSION: This is a promising first report of a patient with a DA-resistant macroprolactinoma who achieved long-term control, in terms of prolactin normalization and tumor volume, under pasireotide treatment alone. Pasireotide could thus be an alternative in prolactinomas resistant to DA. SSTR expression analysis on pathology could guide patient selection. PMID: 30318256 [PubMed - as supplied by publisher] (Source: Annales d'Endocrinologie)
Source: Annales d'Endocrinologie - September 25, 2018 Category: Endocrinology Authors: Lasolle H, Vasiljevic A, Borson-Chazot F, Raverot G Tags: Ann Endocrinol (Paris) Source Type: research

Association between KISS1 rs5780218 promoter polymorphism and onset of growth hormone secreting pituitary adenoma.
This study analyzed the KISS1 c.-145delA (rs5780218) promoter polymorphism in a cohort of patients with growth hormone secreting pituitary adenoma (somatotropinoma) and controls, to investigate its role in the incidence of acromegaly and to assess patient/tumor characteristics. Material and methods rs5780218 allelic and genotypic distributions were compared between 49 somatotropinoma patients and 167 healthy controls. rs5780218 was also assessed in relation to patient characteristics and tumor aggressiveness, as characterized by tumor invasion and resistance to conventional therapy. The relationship between KISS1 mRNA expr...
Source: Annales d'Endocrinologie - September 25, 2018 Category: Endocrinology Authors: Amorim PVGH, Grande IPP, Batista RL, Silveira LFG, Freire ACTB, Bronstein MD, Jallad RS, Trarbach EB Tags: Ann Endocrinol (Paris) Source Type: research

Isolated elevation of thyroglobulin in the follow-up of differentiated thyroid cancer, does it always indicate true persistent disease?
PMID: 30301520 [PubMed - as supplied by publisher] (Source: Annales d'Endocrinologie)
Source: Annales d'Endocrinologie - September 25, 2018 Category: Endocrinology Authors: Raverot V, Borson-Chazot F Tags: Ann Endocrinol (Paris) Source Type: research

TR α inhibits arterial renin-angiotensin system expression and prevents cholesterol accumulation in vascular smooth muscle cells.
CONCLUSION: TRα seems to have an inhibitory impact on AGTand AT1Raexpression, and loss of TRα function in TRα0/0 mice increases tRAS expression in the aortic wall. More importantly, TRα deletion significantly increases VSMC cholesterol content. Our results are consistent with a protective role of TRα against atherosclerosis. PMID: 30292450 [PubMed - as supplied by publisher] (Source: Annales d'Endocrinologie)
Source: Annales d'Endocrinologie - September 25, 2018 Category: Endocrinology Authors: Neggazi S, Hamlat N, Canaple L, Gauthier K, Samarut J, Bricca G, Aouichat-Bouguerra S, Beylot M Tags: Ann Endocrinol (Paris) Source Type: research

Bilateral adrenalectomy in Cushing's disease: Altered long-term quality of life compared to other treatment options.
Abstract OBJECTIVE: Bilateral adrenalectomy (BADX) has become an important treatment of Cushing's disease (CD), especially when other treatment options have failed. The aim of this study was to evaluate the long-term quality of life (QoL) of patients having undergone BADX for CD, in comparison to other therapeutic options. METHODS: Thirty-four patients with CD were identified in two French centers: 17 underwent BADX and the remaining 17 one or more of the following treatments: surgery, medical therapy or radiotherapy. Three questionnaires were filled in by each patient in order to evaluate their QoL: Short Fo...
Source: Annales d'Endocrinologie - September 19, 2018 Category: Endocrinology Authors: Sarkis P, Rabilloud M, Lifante JC, Siamand A, Jouanneau E, Gay E, Chaffanjon P, Chabre O, Raverot G Tags: Ann Endocrinol (Paris) Source Type: research

Expression of β-endorphin in peripheral tissues after systemic administration of lipopolysaccharide as a model of endotoxic shock in mice.
CONCLUSION: Expression of proopiomelanocortin mRNA and β-endorphin was detected in peripheral tissues after systemic administration of lipopolysaccharide. These results provide new evidence that peripheral endogenous opioids can be produced not only as a result of local inflammation but also by severe systemic stress such as endotoxic shock. Further study is required to clarify the role of peripheral β-endorphin during endotoxic shock. PMID: 30243475 [PubMed - as supplied by publisher] (Source: Annales d'Endocrinologie)
Source: Annales d'Endocrinologie - September 19, 2018 Category: Endocrinology Authors: Kido K, Shindo Y, Toda S, Masaki E Tags: Ann Endocrinol (Paris) Source Type: research

Issues in amiodarone-induced thyrotoxicosis: Update and review of the literature.
Abstract Amiodarone, a benzofuranic iodine-rich pan-anti-arrhythmic drug, induces amiodarone-induced thyrotoxicosis (AIT) in 7-15% of patients. AIT is a major issue due to its typical severity and resistance to anti-thyroid measures, and to its negative impact on cardiac status. Classically, AIT is either an iodine-induced thyrotoxicosis in patients with abnormal thyroid (type 1), or due to acute thyroiditis in a "healthy" thyroid (type 2). Determination of the type of AIT is a diagnostic dilemma, as characteristics of both types may be present in some patients. As it is the main etiological factor in AI...
Source: Annales d'Endocrinologie - September 17, 2018 Category: Endocrinology Authors: Maqdasy S, Benichou T, Dallel S, Roche B, Desbiez F, Montanier N, Batisse-Lignier M, Tauveron I Tags: Ann Endocrinol (Paris) Source Type: research

UCP1 transrepression in Brown Fat in vivo and mineralocorticoid receptor anti-thermogenic effects.
CONCLUSION: Our studies demonstrate that MR exerts a pivotal metabolic role by controlling energy expenditure, and provide novel information on how MR participates in the regulation of brown adipocyte function. PMID: 30236456 [PubMed - as supplied by publisher] (Source: Annales d'Endocrinologie)
Source: Annales d'Endocrinologie - September 17, 2018 Category: Endocrinology Authors: Kuhn E, Lamribet K, Viengchareun S, Le Menuet D, Fève B, Lombès M Tags: Ann Endocrinol (Paris) Source Type: research

[Semen quality and fertility: the role of the environment and health].
Abstract Sperm quality appears to be degrading over the past 40 years. Nowadays, more than 35 % of causes of male infertility are still idiopathic. More and more studies have suggested an impact of environment on sperm quality, essentially through epigenetic and hormonal changes. Recent studies in men with impaired sperm quality, have demonstrated epigenetic variations in sperm DNA. These modifications are responsible for modifications of the expression of transmissible genes to theiroffspring. Those transgenerational effects have been particularly illustrated in drosophila and caenorhabditis elegans. In humans, c...
Source: Annales d'Endocrinologie - September 1, 2018 Category: Endocrinology Authors: Lamothe S, Kerlan V, Christin-Maitre S Tags: Ann Endocrinol (Paris) Source Type: research

[Hereditary pheochromocytoma and paraganglioma: screening and follow-up strategies in asymptomatic mutation carriers].
Abstract The management of pheochromocytoma and paraganglioma has deeply evolved over the last years due to the discovery of novel genes of susceptibility, especially SDHx, MAX and TMEM127. While the modalities of diagnosis and management of patients presenting with hereditary pheochromocytoma and paraganglioma are now well defined, screening and follow-up strategies for asymptomatic mutation carriers remain a matter of debate. This raises major questions as these asymptomatic patients will require a lifelong follow-up. The aim of this review is an attempt to give insights on the optimal screening and follow-up st...
Source: Annales d'Endocrinologie - September 1, 2018 Category: Endocrinology Authors: Vermalle M, Tabarin A, Castinetti F Tags: Ann Endocrinol (Paris) Source Type: research

[Differences of Sex Development (DSD): Controversies and Challenges].
ouvattier C Abstract DSD for "Differences of Sex Development" or "Sexual Differences Development" refers to situations where chromosomal, gonadal or anatomical sex is atypical. DSD 46,XX are mainly represented by congenital adrenal hyperplasia (HCS) and are not a diagnostic issue. DSD 46,XY involve genes for the determination and differenciation of the bipotential gonad, making sometimes difficult the choice of sex at birth. They remain without diagnosis in about half of the cases, despite the new genetic techniques (exome, NGS). The management of DSD is complex as well as are the long-term con...
Source: Annales d'Endocrinologie - September 1, 2018 Category: Endocrinology Authors: Bessiène L, Lombès M, Bouvattier C Tags: Ann Endocrinol (Paris) Source Type: research