Qualitative study of self-reported experiences of infertile women with polycystic ovary syndrome through internet discussion forums.
CONCLUSION: The self-reported experiences of infertile women with PCOS are interesting for health practitioners. The psychological impact of PCOS and illness perceptions appear to be improved by the sharing of experiences among women with PCOS, suggesting a beneficial support role of online discussion forums. PMID: 32827451 [PubMed - as supplied by publisher] (Source: Annales d'Endocrinologie)
Source: Annales d'Endocrinologie - August 19, 2020 Category: Endocrinology Authors: Authier M, Normand C, Jego M, Gaborit B, Boubli L, Courbiere B Tags: Ann Endocrinol (Paris) Source Type: research

Ectopic adrenocortical carcinoma of the ovary: An unexpected outcome.
PMID: 32822651 [PubMed - as supplied by publisher] (Source: Annales d'Endocrinologie)
Source: Annales d'Endocrinologie - August 18, 2020 Category: Endocrinology Authors: Laurence S, Robin M, Marie-Pierre TC Tags: Ann Endocrinol (Paris) Source Type: research

Differentiated thyroid carcinoma in sporadic and familial presentations of acromegaly: a case series.
CONCLUSION: In our cohort of sporadic and familial forms of acromegaly with DTC, AIP does not appear to influence thyroid cancer progression. PMID: 32822652 [PubMed - as supplied by publisher] (Source: Annales d'Endocrinologie)
Source: Annales d'Endocrinologie - August 18, 2020 Category: Endocrinology Authors: Rogozinski A, Daly AF, Reyes A, Furioso A, Beckers A, Lowenstein A Tags: Ann Endocrinol (Paris) Source Type: research

The plasma levels of atrial natriuretic peptide and brain natriuretic peptide in type 2 diabetes treated with sodium-glucose cotransporter-2 inhibitor.
Abstract PURPOSE: The aim of this study was to determine the levels of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) after treatment with an SGLT2 inhibitor or DPP4 inhibitor in patients with type 2 diabetes mellitus that was inadequately controlled with insulin and to understand whether the variation of ANP may explain the favorable cardiovascular outcome. METHODS: We enrolled 56 patients with type 2 diabetes mellitus that was inadequately controlled with insulin; the subjects were all 18∼80 years of age. After receiving a stable mean dose of ≥ 20 IU and ≤ 150 IU injectable i...
Source: Annales d'Endocrinologie - August 18, 2020 Category: Endocrinology Authors: Feng X, Qingwei G, Gao G, Yuan L, Li Q, Zhang Y Tags: Ann Endocrinol (Paris) Source Type: research

Recurrent hypothyroidism and thrombopenic thrombotic purpura.
PMID: 32822654 [PubMed - as supplied by publisher] (Source: Annales d'Endocrinologie)
Source: Annales d'Endocrinologie - August 18, 2020 Category: Endocrinology Authors: Briantais A, Dalmas JB, Swiader L, Poullin P, Durand JM Tags: Ann Endocrinol (Paris) Source Type: research

Impact of aerobic training with and without whole-body vibration training on metabolic features and quality of life in non-alcoholic fatty liver disease patients.
maz Y Abstract The present study examined the effectiveness of including exercises with whole-body vibration (WBV) to aerobic training in terms of metabolic features and quality of life. Patients with non-alcoholic fatty liver disease confirmed on imaging underwent an 8-week individualized exercise program randomized between aerobic training with and without WBV. Training was performed at 60-80% heart-rate workload for 155 min/week. The WBV amplitude was 2-4 mm and the training frequency was 30 Hz, for 15 min. Assessments were carried out on surrogate scores of steatosis and fibrosis in...
Source: Annales d'Endocrinologie - August 5, 2020 Category: Endocrinology Authors: Saldıran TÇ, Mutluay FK, Yağcı İ, Yılmaz Y Tags: Ann Endocrinol (Paris) Source Type: research

Cardiac complications of thyroid hormone resistance syndromes.
Abstract Thyroid hormones exert their action by binding to their thyroid hormone receptors among other mechanisms. They are involved in different cardiac functions, including contractility and rhythm. The mutation of thyroid hormone receptor β is the main cause of thyroid hormone resistance. The cardiac phenotype of mutated patients has been studied in several cohorts of patients with different mutations. Tachycardia, palpitation and cardiac arrhythmia frequently appear; atrial flutter/fibrillation is found in up to 20%. Cardiac systolic and diastolic functions are impaired compared to hyperthyroid or euthyro...
Source: Annales d'Endocrinologie - June 5, 2020 Category: Endocrinology Authors: Illouz F, Briet C, Mirebeau-Prunier D, Bouhours-Nouet N, Coutant R, Sibilia P, Rodien P Tags: Ann Endocrinol (Paris) Source Type: research

Aldosterone receptor antagonists.
Abstract Blocking the mineralocorticoid receptor (MR) is one of the most effective ways of reducing blood pressure in patients with resistant hypertension and improving cardiovascular prognosis in patients with heart failure with reduced ejection fraction and left ventricular dysfunction after myocardial infarction. Blockade of the biological effects of aldosterone has mostly been achieved with spironolactone and eplerenone, the two steroidal MR antagonists currently on the market. Development of new non-steroidal dihydropyridine-based third- and fourth-generation MR antagonists is ongoing. These antagonists are h...
Source: Annales d'Endocrinologie - May 27, 2020 Category: Endocrinology Authors: Azizi M Tags: Ann Endocrinol (Paris) Source Type: research

Management of thyroid dysfunctions in the elderly.French Endocrine Society consensus 2019 guidelines*.Short version.
PMID: 32446837 [PubMed - as supplied by publisher] (Source: Annales d'Endocrinologie)
Source: Annales d'Endocrinologie - May 21, 2020 Category: Endocrinology Authors: Goichot B, Raverot V, Klein M, Vija L, Abeillon J, Lairez O, Leroy R, Cailleux A, Wolff P, Groussin L, Kaltenbach G, Caron P Tags: Ann Endocrinol (Paris) Source Type: research

Levothyroxine dose adjustment in hypothyroid patients following gastric sleeve surgery.
CONCLUSION: Despite a decrease in daily levothyroxine dose correlating with weight loss at 12 months, the absence of correlation with weight-adjusted dose suggests the involvement of confounding factors such as poor drug absorption or altered thyroid function. Further studies are required to elucidate the absorption of levothyroxine. PMID: 32445637 [PubMed - as supplied by publisher] (Source: Annales d'Endocrinologie)
Source: Annales d'Endocrinologie - May 20, 2020 Category: Endocrinology Authors: Gilly O, Richou M, Taillard V, Brauwere DP, Donici I, Guedj AM Tags: Ann Endocrinol (Paris) Source Type: research

COVID-19 in diabetic patients: related risks and specifics of management.
Abstract Diabetes is among the most frequently reported comorbidities in patients infected with COVID-19. According to current data, diabetic patients do not appear to be at increased risk of contracting SARS-CoV-2 compared to the general population. On the other hand, diabetes is a risk factor for developing severe and critical forms of COVID-19, the latter requiring admission to an intensive care unit and/or use of invasive mechanical ventilation, with high mortality rates. The characteristics of diabetic patients at risk for developing severe and critical forms of COVID-19, as well as the prognostic impact of d...
Source: Annales d'Endocrinologie - May 12, 2020 Category: Endocrinology Authors: Orioli L, Hermans MP, Thissen JP, Maiter D, Vandeleene B, Yombi JC Tags: Ann Endocrinol (Paris) Source Type: research

Case report: A rare cause of severe hypophosphatemia.
We present the case of a 62-year-old woman who consulted for intense asthenia and needed periodic intravenous iron infusions with ferric carboxymaltose due to an important ferropenic anaemia. As a side effect, she presented severe hypophosphatemia. PMID: 32409006 [PubMed - as supplied by publisher] (Source: Annales d'Endocrinologie)
Source: Annales d'Endocrinologie - May 4, 2020 Category: Endocrinology Authors: Román-Gimeno S, Ortez-Toro JJ, Peteiro-Miranda CM, Sanz-Martín B, Urdaniz-Borque R Tags: Ann Endocrinol (Paris) Source Type: research

Amiodarone-induced thyrotoxicosis.
Abstract Amiodarone-induced thyrotoxicosis (AIT) are not uncommon endocrinopathies. Clinicians are sometimes faced with difficult diagnostic and therapeutic situations. The disease pathophysiology is partially understood, explaining the lack of predictive factors for occurrence. Different international recommendations for their management have been published: the most recent in 2018 by the European Thyroid Association (ETA) (Ross et al., 2016; Bartalena et al., 2018). The purpose of this paper is to present the essential concepts for their management and to review the literature since 2018. PMID: 32409004 [Pu...
Source: Annales d'Endocrinologie - April 29, 2020 Category: Endocrinology Authors: Schubert L, Bricaire L, Groussin L Tags: Ann Endocrinol (Paris) Source Type: research

Clinical phenotype of mitochondrial diabetes due to rare mitochondrial DNA mutations.
CONCLUSION: Although no specific metabolic phenotype could be identified suggesting or eliminating implication of rare mtDNA mutations in diabetes, clinical phenotypes featured more frequent neurological signs. PMID: 32409007 [PubMed - as supplied by publisher] (Source: Annales d'Endocrinologie)
Source: Annales d'Endocrinologie - April 28, 2020 Category: Endocrinology Authors: Decoux-Poullot AG, Bannwarth S, Procaccio V, Lebre AS, Jardel C, Vialettes B, Paquis-Flucklinger V, Chevalier N Tags: Ann Endocrinol (Paris) Source Type: research

Covid-19: The challenges facing endocrinology.
PMID: 32381288 [PubMed - as supplied by publisher] (Source: Annales d'Endocrinologie)
Source: Annales d'Endocrinologie - April 25, 2020 Category: Endocrinology Authors: Pugeat M, Chabre O, Van Tyghem MC Tags: Ann Endocrinol (Paris) Source Type: research

Renin-angiotensin-aldosterone system and COVID-19 infection.
Abstract With the multiplication of COVID-19 severe acute respiratory syndrome cases due to SARS-COV2, some concerns about angiotensin-converting enzyme 1 (ACE1) inhibitors (ACEi) and angiotensin II type 1 receptor blockers (ARB) have emerged. Since the ACE2 (angiotensin-converting enzyme 2) enzyme is the receptor that allows SARS COV2 entry into cells, the fear was that pre-existing treatment with ACEi or ARB might increase the risk of developing severe or fatal severe acute respiratory syndrome in case of COVID-19 infection. The present article discusses these concerns. ACE2 is a membrane-bound enzyme (carboxype...
Source: Annales d'Endocrinologie - April 21, 2020 Category: Endocrinology Authors: Alexandre J, Cracowski JL, Richard V, Bouhanick B, 'Drugs, COVID-19' working group of the French Society of Pharmacology, Therapeutics Tags: Ann Endocrinol (Paris) Source Type: research

Gonad differentiation toward ovary.
Abstract Gonad differentiation depends on a set of cellular and hormonal signals interacting in a specific order, with very precise windows of action, to contribute to the establishment of the genital tract and a male or female phenotype. Research initially focused on the stages of gonad differentiation toward testis, in particular following the identification in 1990 of the SRY factor on chromosome Y. The mechanisms involved in gonad differentiation toward ovary took longer to identify. Thanks to patients with different sexual development (DSD) and animal knock-out models, description of the cascades involved in ...
Source: Annales d'Endocrinologie - April 15, 2020 Category: Endocrinology Authors: Lamothe S, Bernard V, Christin-Maitre S Tags: Ann Endocrinol (Paris) Source Type: research

What do you need to know about mass spectrometry? A brief guide for endocrinologists.
We describe the general principles of LCMS and the routine applications so far developed in hormonology. The purpose is to familiarise endocrinologists with the techniques under development and their pros and cons. PMID: 32340850 [PubMed - as supplied by publisher] (Source: Annales d'Endocrinologie)
Source: Annales d'Endocrinologie - April 11, 2020 Category: Endocrinology Authors: Corcuff JB, Ducint D, Brossaud J Tags: Ann Endocrinol (Paris) Source Type: research

Tocilizumab in glucocorticoid-resistant graves orbitopathy. A case series report of a mexican population.
CONCLUSIONS: TCZ is a therapeutic option for glucocorticoid-resistant orbitopathy, and should be considered in second line due to the cost of treatment or in first line in patients with contraindications to intravenous GC pulse therapy. PMID: 32340849 [PubMed - as supplied by publisher] (Source: Annales d'Endocrinologie)
Source: Annales d'Endocrinologie - April 10, 2020 Category: Endocrinology Authors: Ceballos-Macías José J, Rivera-Moscoso R, Flores-Real Jorge A, Vargas-Sánchez J, Ortega-Gutiérrez G, Madriz-Prado R, Velasco-Ramos PC, Muñoz-Monroy Omar E, Meneses-Pérez Anna C, Fernández-Morales Irma N, Hernández-Moreno A Tags: Ann Endocrinol (Paris) Source Type: research

Cardiovascular complications of lipodystrophic syndromes - focus on laminopathies.
oux C PMID: 32201029 [PubMed - as supplied by publisher] (Source: Annales d'Endocrinologie)
Source: Annales d'Endocrinologie - March 4, 2020 Category: Endocrinology Authors: Mosbah H, Vatier C, Boccara F, Jéru I, Vantyghem MC, Donadille B, Wahbi K, Vigouroux C Tags: Ann Endocrinol (Paris) Source Type: research

"Is there any reason to treat subclinical hypo and hyperthyroidism?"
"Is there any reason to treat subclinical hypo and hyperthyroidism?" Ann Endocrinol (Paris). 2020 Mar 04;: Authors: Biondi B Abstract Subclinical thyroid disease represents an early stage of thyroid dysfunction, which is usually asymptomatic and biochemically defined; its diagnosis can be performed thanks to the high sensitivity of the hypothalamic-pituitary-thyroid axis. The approach to this disorder requires correct diagnosis, clinical assessment and treatment. Cardiovascular diseases (e.g. atrial fibrillation, heart failure, and coronary heart disease), bone loss and fractures, and dement...
Source: Annales d'Endocrinologie - March 4, 2020 Category: Endocrinology Authors: Biondi B Tags: Ann Endocrinol (Paris) Source Type: research

Therapeutic applications of thyroid hormone analogues.
Abstract Cellular thyroid hormone homeostasis requires adequate function of: (1) thyroid hormone transporter proteins at the plasma membrane, (2) deiodinating enzymes and (3) nuclear thyroid hormone receptors (TRs). Defects in any of these processes give rise to distinct disease entities, collectively called thyroid hormone signaling disorders. Thyroid hormone analogues hold therapeutic potential in thyroid hormone signaling disorders by bypassing defective transporters or binding to mutant TRs. This review will focus on the application of analogues in thyroid hormone signaling disorders, particularly monocarboxyl...
Source: Annales d'Endocrinologie - March 4, 2020 Category: Endocrinology Authors: Visser WE Tags: Ann Endocrinol (Paris) Source Type: research

Androgenic effects on ventricular repolarization: A translational study from the international pharmacovigilance database to iPSC-cardiomyocytes.
Abstract BACKGROUND: Male hypogonadism, arising from a range of etiologies including androgen-deprivation therapies (ADTs), has been reported as a risk factor for acquired long-QT syndrome (aLQTS) and torsades de pointes (TdP). A full description of the clinical features of aLQTS associated with ADT and of underlying mechanisms is lacking. METHODS: We searched the international pharmacovigilance database VigiBase for men (n=6 560 565 individual case safety reports) presenting with aLQTS, TdP, or sudden death associated with ADT. In cardiomyocytes derived from induced pluripotent stem cells from men, we studie...
Source: Annales d'Endocrinologie - February 29, 2020 Category: Endocrinology Authors: Salem JE, Yang T, Moslehi JJ, Waintraub X, Gandjbakhch E, Bachelot A, Hidden-Lucet F, Hulot JS, Knollmann BC, Lebrun-Vignes B, Funck-Brentano C, Glazer AM, Roden DM Tags: Ann Endocrinol (Paris) Source Type: research

Thyroid hormone and mammalian tissue regeneration.
Abstract Recent articles show that thyroid hormone is a key determinant of regeneration. The regeneration capacity in adults of two cell types, cerebellum neurons and cardiomyocytes, disappeared during mammalian evolution. However, it persists at early stages of development. Data indicate that thyroid hormone, bound to its TRα1 nuclear receptor, defines the timing of the developmental transition which results in a loss of regenerative capacity. The identification of hormone-activated genes that are responsible for this transition is a new challenge for regenerative medicine. PMID: 32172940 [PubMed - as ...
Source: Annales d'Endocrinologie - February 28, 2020 Category: Endocrinology Authors: Flamant F Tags: Ann Endocrinol (Paris) Source Type: research

Monitoring patients receiving dopamine agonist therapy for hyperprolactinaemia.
This article reviews the proposed pathophysiological mechanism underlying the phenomenon of dopamine agonist valvulopathy, the characteristic echocardiographic changes seen, summarises the published literature on the incidence of valvulopathy with low dose cabergoline and examines the previous and current evidence-based screening guidelines. PMID: 32178837 [PubMed - as supplied by publisher] (Source: Annales d'Endocrinologie)
Source: Annales d'Endocrinologie - February 28, 2020 Category: Endocrinology Authors: Stiles CE, Steeds RP, Drake WM Tags: Ann Endocrinol (Paris) Source Type: research

Improvement in arterial stiffness (pOpm ètre®) after bariatric surgery. Results from a prospective study.
CONCLUSION: These results suggest that pathological arterial stiffness may resolve following bariatric surgery independently of the other factors influencing cardiovascular risk in obesity. PMID: 32081364 [PubMed - as supplied by publisher] (Source: Annales d'Endocrinologie)
Source: Annales d'Endocrinologie - February 1, 2020 Category: Endocrinology Authors: Frey S, Jacobi D, Pichelin M, Cariou B, Mirallié E, Blanchard C Tags: Ann Endocrinol (Paris) Source Type: research

Ultrasound and cytological characteristics of non-invasive follicular thyroid neoplasm with papillary-like nuclear features compared to papillary carcinomas.
Abstract INTRODUCTION: NIFTP (non-invasive follicular thyroid neoplasm with papillary-like nuclear features, formerly non-invasive encapsulated follicular variant of papillary thyroid carcinoma) has been removed from the carcinoma category because of its indolent character and good prognosis. This change impacts clinical and surgical management, since these tumors no longer require total thyroidectomy, or complementary radioactive iodine therapy for
Source: Annales d'Endocrinologie - January 25, 2020 Category: Endocrinology Authors: Boursier L, Clerc Urmes I, Garon J, Klein M, Demarquet L Tags: Ann Endocrinol (Paris) Source Type: research

Prevalence and progression of carbohydrate disorders in patients with pheochromocytoma/paraganglioma: retrospective single-center study.
CONCLUSIONS: Carbohydrate disorders affect approximately 50% of pheochromocytoma patients; 30% develop overt diabetes, which may be the only clinical manifestation in some rare cases. Pheochromocytoma-related diabetes is more likely to affect patients with predominant adrenaline secretion. It is often easy to control and usually requires oral antidiabetic treatment. Reversibility of carbohydrate disorders depend on severity, preoperative metanephrine level, age and weight. PMID: 32067697 [PubMed - as supplied by publisher] (Source: Annales d'Endocrinologie)
Source: Annales d'Endocrinologie - January 25, 2020 Category: Endocrinology Authors: Elenkova A, Matrozova J, Vasilev V, Robeva R, Zacharieva S Tags: Ann Endocrinol (Paris) Source Type: research

Long-term progression of non-invasive follicular thyroid neoplasm with papillary-like nuclear features: A single-center retrospective study of the French Marne-Ardennes thyroid cancer registry.
CONCLUSION: Consistently with previous studies, our results showed the indolent course of NIFTP and that risk of recurrence after complete resection is very low (zero in our cohort), even when size is ≥4cm and in absence of adjuvant RAI treatment. Prospective studies are needed to confirm those results. PMID: 32057425 [PubMed - as supplied by publisher] (Source: Annales d'Endocrinologie)
Source: Annales d'Endocrinologie - January 25, 2020 Category: Endocrinology Authors: Richard C, Debreuve-Theresette A, Patey M, Brabencova E, Filieri C, Zalzali M, Schvartz C Tags: Ann Endocrinol (Paris) Source Type: research

Fluctuation analysis of postoperative secretory status in patients operated for acromegaly.
CONCLUSIONS: Whereas outcome in grades I and III-IV seems to be determined by 1 year, grade II discordant patients' outcome remains uncertain even after 1 year. PMID: 31982107 [PubMed - as supplied by publisher] (Source: Annales d'Endocrinologie)
Source: Annales d'Endocrinologie - December 19, 2019 Category: Endocrinology Authors: Graillon T, Castinetti F, Boucekine M, Cuny T, Morange I, Fuentes S, Figarella-Branger D, Albarel F, Brue T, Dufour H Tags: Ann Endocrinol (Paris) Source Type: research

Lipodystrophic syndromes: From diagnosis to treatment.
Vigouroux C Abstract Lipodystrophic syndromes are acquired or genetic rare diseases, characterised by a generalised or partial lack of adipose tissue leading to metabolic alterations linked to strong insulin resistance. They encompass a variety of clinical entities due to primary defects in adipose differentiation, in the structure and/or regulation of the adipocyte lipid droplet, or due to immune-inflammatory aggressions, chromatin deregulations and/or mitochondrial dysfunctions affecting adipose tissue. Diagnosis is based on clinical examination, pathological context and comorbidities, and on results of metaboli...
Source: Annales d'Endocrinologie - December 16, 2019 Category: Endocrinology Authors: Sollier C, Vatier C, Capel E, Lascols O, Auclair M, Janmaat S, Fève B, Jéru I, Vigouroux C Tags: Ann Endocrinol (Paris) Source Type: research

Comparison of 68Ga-Dotatate PET/CT and 18F-FDOPA PET/CT for the diagnosis of pancreatic neuroendocrine tumors in a MEN1 patient.
Abstract CONTEXT: Pancreatic neuroendocrine tumors (PNETs) occur in more than 80% of patients with multiple endocrine neoplasia type 1 (MEN1) syndrome, with predominance of small (
Source: Annales d'Endocrinologie - December 16, 2019 Category: Endocrinology Authors: Jullien M, Reichert T, D'Anella P, Castinetti F, Barlier A, Brue T, Taieb D, Cuny T Tags: Ann Endocrinol (Paris) Source Type: research

Independent association of vitamin D and insulin resistance in obstructive sleep apnea.
Abstract BACKGROUND: Vitamin D insufficiency and/or high levels of parathyroid hormone (PTH) seem to be associated with abnormal glucose metabolism, which is frequent in obstructive sleep apnea (OSA). The purpose of this study was to investigate vitamin D and PTH concentrations in OSA, and to explore potential links between vitamin D, PTH and insulin resistance (IR). METHODS: A total of 112 subjects with suspected OSA were recruited consecutively, and evaluated by polysomnography (PSG) to determine the number of apnea and hypopnea episodes per hour of sleep (apnea/hypopnea index: AHI). OSA...
Source: Annales d'Endocrinologie - November 1, 2019 Category: Endocrinology Authors: Fan Z, Cao B, Long H, Feng L, Li Q, Zhang Y, Li T Tags: Ann Endocrinol (Paris) Source Type: research

Adrenocortical carcinoma: Impact of surgical treatment.
amy A Abstract Compared to benign adrenal lesions, secreting or otherwise, malignant adrenocortical carcinoma is rare. Overall prognosis is poor, with
Source: Annales d'Endocrinologie - October 18, 2019 Category: Endocrinology Authors: Mirallié E, Blanchard C, Caillard C, Rodien P, Briet C, Mucci S, Drui D, Hamy A Tags: Ann Endocrinol (Paris) Source Type: research

Can incomplete adrenal venous sampling data be used in predicting the subtype of primary aldosteronism?
CONCLUSION: The diagnostic model in this study contributes to clinical decision-making in patients with only partial PA with incomplete AVS data. PMID: 31722788 [PubMed - as supplied by publisher] (Source: Annales d'Endocrinologie)
Source: Annales d'Endocrinologie - October 18, 2019 Category: Endocrinology Authors: Lin L, Zhou L, Guo Y, Liu Z, Chen T, Liu Z, Wang K, Li J, Zhu Y, Ren Y Tags: Ann Endocrinol (Paris) Source Type: research

Metallothionein protein and minichromosome maintenance protein-2 expression in adrenocortical tumors.
Abstract AIM: Some resected adrenal-confined adrenocortical carcinomas metastasize and others not. The present study was designed to evaluate the expression of metallothionein protein (MT) and minichromosome maintenance protein-2 (MCM2) in adrenocortical carcinomas and adrenocortical adenomas, and to test the correlation between this and adrenocortical carcinoma aggressiveness. MATERIALS AND METHODS: The study comprised 14 patients operated on for adrenocortical carcinoma, 15 operated on for adrenocortical adenoma and 2 with normal adrenals. Hematoxylin-eosin staining was used for histological ...
Source: Annales d'Endocrinologie - October 18, 2019 Category: Endocrinology Authors: Saiegh L, Sheikh-Ahmad M, Shechner C, Reut M, Darawsha Y, Zolotov S, Shefer H, Bejar I, Bejar J Tags: Ann Endocrinol (Paris) Source Type: research

When Graves' disease resists to surgery: A rare case of an association with follicular thyroid cancer in struma ovarii.
PMID: 31708080 [PubMed - as supplied by publisher] (Source: Annales d'Endocrinologie)
Source: Annales d'Endocrinologie - October 18, 2019 Category: Endocrinology Authors: Richa C, Quilhot P, Uzan C, Buffet C, Lussey-Lepoutre C Tags: Ann Endocrinol (Paris) Source Type: research

Insuffisance surr énalienne secondaire : actualités diagnostiques et thérapeutiques: News in diagnosis and therapeutics of secondary adrenal insufficiency.
Insuffisance surrénalienne secondaire : actualités diagnostiques et thérapeutiques: News in diagnosis and therapeutics of secondary adrenal insufficiency. Ann Endocrinol (Paris). 2019 Sep;80 Suppl 1:S1-S9 Authors: Vinolas H, Lombès M, Tabarin A Abstract Immunotherapy and opioids treatment are new causes of secondary adrenal insufficiency (SAI). Prevalence of SAI with immunotherapy is more frequent with combined therapy (8% vs 4 to 10% with CTLA4 blocking antibody and 1% with PD1 blocking antibody). Although hypophysitis are more frequently observed with CTLA4 blocking antib...
Source: Annales d'Endocrinologie - September 1, 2019 Category: Endocrinology Authors: Vinolas H, Lombès M, Tabarin A Tags: Ann Endocrinol (Paris) Source Type: research

Acrom égalie : améliorer la prise en charge: Acromegaly: improving care.
Acromégalie : améliorer la prise en charge: Acromegaly: improving care. Ann Endocrinol (Paris). 2019 Sep;80 Suppl 1:S10-S18 Authors: Mosbah H, Brue T, Chanson P Abstract Acromegaly is characterized by increased release of growth hormone (GH) and, consequently, Insulin-Like Growth Factor I (IGF-I), most often by a pituitary adenoma. Prolonged exposure to excess hormone leads to progressive somatic disfigurement and a wide range of systemic manifestations that are associated with increased mortality. Transsphenoidal adenomectomy is the treatment of choice of GH-secreting pituitary tumors b...
Source: Annales d'Endocrinologie - September 1, 2019 Category: Endocrinology Authors: Mosbah H, Brue T, Chanson P Tags: Ann Endocrinol (Paris) Source Type: research

La n éoplasie endocrinienne multiple de type 1 : mise au point après le congrès de l’ENETS 2019: Multiple Endocrine Neoplasia Type 1: Development after the ENETS 2019 Congress.
La néoplasie endocrinienne multiple de type 1 : mise au point après le congrès de l’ENETS 2019: Multiple Endocrine Neoplasia Type 1: Development after the ENETS 2019 Congress. Ann Endocrinol (Paris). 2019 Sep;80 Suppl 1:S19-S28 Authors: Vialon M, Desailloud R, Caron P Abstract Multiple Endocrine Neoplasia Type 1 (NEM1) is related to mutations of the menin gene. It is an autosomal dominant disease. Its prevalence is about 1/30 000 with a hugh penetrance. There is no genotype-phenotype correlation. This hereditary syndrome is characterized by the presence of tumors of the endo...
Source: Annales d'Endocrinologie - September 1, 2019 Category: Endocrinology Authors: Vialon M, Desailloud R, Caron P Tags: Ann Endocrinol (Paris) Source Type: research

Le syndrome des ovaires polykystiques : quelles nouveaut és en 2019 ?: Keeping up with PCOS in 2019.
Le syndrome des ovaires polykystiques : quelles nouveautés en 2019 ?: Keeping up with PCOS in 2019. Ann Endocrinol (Paris). 2019 Sep;80 Suppl 1:S29-S37 Authors: Gourbesville C, Kerlan V, Reznik Y Abstract PolyCystic Ovary Syndrome (PCOS) is the first endocrinopathy of women of child-bearing age and the leading cause of anovulatory infertility. The pathophysiology of this syndrome is complex and involves genetic traits highlighted by GWAS and epigenetic traits with DNA methylation modifications. Initially described as an ovarian disease, works carried out over recent years were turned towards ne...
Source: Annales d'Endocrinologie - September 1, 2019 Category: Endocrinology Authors: Gourbesville C, Kerlan V, Reznik Y Tags: Ann Endocrinol (Paris) Source Type: research

Weight-loss with activation of brown fat: Suspect pheochromocytoma.
CONCLUSION: Brown fat activation may mislead diagnosis of pheochromocytoma, suggesting multi-metastatic extra-adrenal tumor, if clinicians are not aware of it. PMID: 31606198 [PubMed - as supplied by publisher] (Source: Annales d'Endocrinologie)
Source: Annales d'Endocrinologie - July 26, 2019 Category: Endocrinology Authors: Geslot A, Bennet A, Hitzel A, Thoulouzan M, Mouly C, Savagner F, Quintyn-Ranty ML, Caron P, Vezzosi D Tags: Ann Endocrinol (Paris) Source Type: research

TSH inhibits eNOS expression in HMEC-1 cells through the TSHR/PI3K/AKT signaling pathway.
Abstract OBJECTIVE: To investigate the effects of thyroid-stimulating hormone (TSH) on the expression of endothelial nitric oxide synthase (eNOS) in human microvascular endothelial cells (HMEC-1) and explore the potential mechanism. MATERIALS AND METHODS: Expression of thyroid-stimulating hormone receptor (TSHR) in HMEC-1 cells was determined by immunofluorescence, reverse transcription-polymerase chain reaction (RT-PCR), and Western blotting. Cell proliferation and the production of nitric oxide (NO) and superoxide anion (SA) were measured after TSH treatment. eNOS expression and AKT phosphorylation were det...
Source: Annales d'Endocrinologie - July 26, 2019 Category: Endocrinology Authors: Chen J, Shi M, Wang N, Yi P, Sun L, Meng Q Tags: Ann Endocrinol (Paris) Source Type: research

Apparent resistance to thyroid hormones: From biological interference to genetics.
Abstract Resistance to thyroid hormones syndrome is defined as increased thyroxine (T4) and triiodothyronine (T3) concentrations associated with normal or sometimes increased thyrotropin (TSH) concentration. This is usually due to a pathogenic variant with loss of function of the gene coding for thyroid hormone receptor β (THRB). This discrepancy in thyroid hormones (TH) and TSH concentrations is also frequently observed in the presence of analytical interference, notably alteration of TH transport proteins in serum. During 2017, 58 samples were sent to our laboratory in the Angers University Hospit...
Source: Annales d'Endocrinologie - July 26, 2019 Category: Endocrinology Authors: Dieu X, Sueur G, Moal V, Boux de Casson F, Bouzamondo N, Bouhours N, Briet C, Illouz F, Reynier P, Coutant R, Rodien P, Mirebeau-Prunier D Tags: Ann Endocrinol (Paris) Source Type: research

Sphingosine-1-phosphate (S1P) in ovarian physiology and disease.
ez D, Rosales-Torres AM Abstract Sphingosine-1-phoshate (S1P) is a membrane sphingolipid involved in several physiological processes, including cell proliferation, tissue growth, cell survival and migration, inflammation, vasculogenesis, and angiogenesis. Herein, we review the most critical effects of S1P on ovarian function, including its physiological and pathophysiological effects. Based on the available evidence, S1P plays an important role in ovarian physiology, participating as an essential stimulator of follicular development in both the preantral and antral phases, as well as in ovulation and corpus luteum...
Source: Annales d'Endocrinologie - July 26, 2019 Category: Endocrinology Authors: Hernández-Coronado CG, Guzmán A, Castillo-Juárez H, Zamora-Gutiérrez D, Rosales-Torres AM Tags: Ann Endocrinol (Paris) Source Type: research

Feasibility criteria for total thyroidectomy in outpatient surgery.
CONCLUSION: Surgery time, female gender, repeated dissection and total thyroidectomy for benign adenoma are risk factors that should be considered in decision-making for performing TT on an outpatient basis. PMID: 31400860 [PubMed - as supplied by publisher] (Source: Annales d'Endocrinologie)
Source: Annales d'Endocrinologie - July 26, 2019 Category: Endocrinology Authors: Philippe JB, Riou J, Lemoult A, Sarfati-Lebreton M, Hamy A, Mucci S Tags: Ann Endocrinol (Paris) Source Type: research

Diagnosis, pathology, and management of TSH-secreting pituitary tumors. A single-center retrospective study of 20  patients from 1981 to 2014.
The objective of this study was to describe initial presentation and follow-up in patients presenting TSH-secreting tumors and to characterize the pathological features, based on a cohort of 20 patients treated in our referral center, between 1981 and 2014. Most of the patients (75%) were female, aged around 50 years (mean: 50±13 years). Initial symptoms were hyperthyroidism (8/20) and/or tumor mass-related symptoms. Median time to diagnosis was 18 months. Biochemical hyperthyroidism was found in 15 patients. Most of the tumors were macroadenomas (75%) and 30% were invasive. Seventeen patien...
Source: Annales d'Endocrinologie - July 26, 2019 Category: Endocrinology Authors: Căpraru OM, Gaillard C, Vasiljevic A, Lasolle H, Borson-Chazot F, Raverot V, Jouanneau E, Trouillas J, Raverot G Tags: Ann Endocrinol (Paris) Source Type: research

Micropapillary carcinoma: Description and rise in incidence in the French Marne-Ardennes thyroid cancer registry.
Abstract CONTEXT: Yearly incidence of thyroid cancer has nearly tripled in the past four decades, due to improvements in and better use of diagnostic procedures, enabling detection of smaller tumors, and notably micropapillary carcinoma (MPC: ≤10 mm). OBJECTIVES: The aim of our study was to confirm increasing incidence, to describe the characteristics and circumstances of discovery, and to examine the reasons for this rise in incidence of MPCs, based on the French Marne-Ardennes registry for 1975-2014. DESIGN: This was a retrospective observational cohort study. RESULTS: Two thousand six hun...
Source: Annales d'Endocrinologie - July 8, 2019 Category: Endocrinology Authors: Zalzali M, Debreuve A, Richard C, Filieri C, Schvartz C Tags: Ann Endocrinol (Paris) Source Type: research

Cardiothyreosis: Prevalence and risk factors.
CONCLUSIONS: The prevalence of CT in patients with overt hyperthyroidism was relatively low. Cardiac complications were AF and CHF with a clear predominance of AF. Advanced age was the only independent risk factor of CT. Cardiac complications may be seen even if hyperthyroidism is not biologically severe. PMID: 31235068 [PubMed - as supplied by publisher] (Source: Annales d'Endocrinologie)
Source: Annales d'Endocrinologie - June 21, 2019 Category: Endocrinology Authors: Yazidi M, Chihaoui M, Oueslati H, Chaker F, Rjeb O, Rjaibi S, Ouali S, Slimane H Tags: Ann Endocrinol (Paris) Source Type: research

New insights into the pathophysiology and treatment of neuroendocrine tumors.
PMID: 31153387 [PubMed - in process] (Source: Annales d'Endocrinologie)
Source: Annales d'Endocrinologie - June 1, 2019 Category: Endocrinology Authors: Persani L, Scientific Committee of the Klotz Days 2019 Tags: Ann Endocrinol (Paris) Source Type: research