Identification of seizure clusters using free text notes in an electronic seizure diary.
CONCLUSION: This exploratory study demonstrates a novel approach applying lexical analysis to previously untapped FTN in a large electronic seizure diary database. Free text notes captured information about SC not available from the structured diary data. Diary FTN contain information of high importance to people with epilepsy, written in their own words. PMID: 33096508 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - October 20, 2020 Category: Neurology Authors: Werbaneth K, Cramer JA, Bartfeld E, Fisher RS Tags: Epilepsy Behav Source Type: research

Can change in gut microbiota composition be used as a surrogate marker of treatment efficacy of ketogenic diet in patients with drug-resistant epilepsy?
Abstract To answer the question posed in the title of the manuscript, we critically examined the connection between ketogenic diet (KD), gut microbiota (GM), and epilepsy. We conclude that although the evidence for a KD-GM-epilepsy link is fairly robust in rodent epilepsy models, it is very hard to draw meaningful conclusions in humans. The limitations of human studies that have investigated the KD-microbiota-epilepsy relationship include small sample size, a heterogeneous patient population with regard to age and epilepsy type, failure to account for the effect of dietary habits, antiseizure drugs (ASDs) and come...
Source: Epilepsy and Behaviour - October 19, 2020 Category: Neurology Authors: Thambi M, Nathan J, Radhakrishnan K Tags: Epilepsy Behav Source Type: research

Ictal EEG in sunflower syndrome: Provoked or unprovoked seizures?
Abstract Sunflower syndrome (SS) is a rare, photosensitive epilepsy characterized by an attraction to light and highly stereotyped seizures with associated hand-waving (HW). It is controversial whether HW is part of the seizure or a provoking factor; therefore, we aimed to characterize the ictal electroencephalogram (EEG) in patients with SS. Video-EEG (vEEG) and charts of five patients with SS with HW during vEEG from Massachusetts General Hospital's Pediatric Epilepsy Program were reviewed and analyzed. In four out of five patients, the ictal EEG showed high amplitude (500-700 μV) 3-4 Hz generalized spike...
Source: Epilepsy and Behaviour - October 15, 2020 Category: Neurology Authors: Sourbron J, Ayub N, Luo Y, Thiele EA Tags: Epilepsy Behav Source Type: research

Empowering seizure management skills: Knowledge, attitudes, and experiences of school staff trained in administering rescue drugs in Northern Italy.
Abstract PURPOSE: The administration of rescue medication at school concerns students for which it may be essential, on doctor's prescription, to take therapy during school hours. In this case, since the parents are absent, the first rescuer is necessarily the school staff, who should be properly trained because prolonged seizures can cause severe harm and even death. METHODS: Every year, the Local Health Unit "TO3" in Northern Italy, provides training for school staff to administrate rescue medication at school. From December 2019 to February 2020, the same questionnaire was administered to school ...
Source: Epilepsy and Behaviour - October 8, 2020 Category: Neurology Authors: Bert F, Pompili E, Gualano MR, Venuti S, Minniti D, Siliquini R Tags: Epilepsy Behav Source Type: research

Oral language in children with benign childhood epilepsy with centrotemporal spikes.
CONCLUSION: The early assessment of these capacities and the possible need for therapeutic intervention should be emphasized, in order to minimize the impact on their academic performance and quality of life. PMID: 33027869 [PubMed - in process] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - October 1, 2020 Category: Neurology Authors: Teixeira JM, Santos ME, Oom P Tags: Epilepsy Behav Source Type: research

Intravenous brivaracetam and lorazepam for acute seizure control: Are they equally effective?
PMID: 33004278 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - September 27, 2020 Category: Neurology Authors: Panda PK, Saini K, Sharawat IK Tags: Epilepsy Behav Source Type: research

Evaluation of reliability and validity of the Persian version of the Neurological Disorders Depression Inventory for Epilepsy (P-NDDI-E).
Abstract INTRODUCTION: Major depression is common among people with epilepsy (PWE), but it is underdiagnosed. The aim of the present study was to assess the reliability and validity of the Persian version of the Neurological Disorders Depression Inventory for Epilepsy (P-NDDI-E) as a screening tool for major depression in patients with epilepsy. METHOD: A total of 210 patients suffering from epilepsy have been assessed using the NDDI-E and the Beck Depression Inventory-II (BDI-II) with no difficulty in understanding or answering the Persian version of the questionnaire. Patients identified as depressed under ...
Source: Epilepsy and Behaviour - September 25, 2020 Category: Neurology Authors: Sahebi Vaighan N, Delavar Kasmaei H, Hesami O, Azargashb E, Mohtasham Alsharieh A Tags: Epilepsy Behav Source Type: research

Mortality implications and factors associated with nonengagement in a public epilepsy care initiative in a transient population.
CONCLUSIONS: Nonacceptance of a community-based public epilepsy care initiative is associated with high premature mortality, mostly attributed to epilepsy-related causes. Older age, ethnic status, and economic deprivation are factors associated with nonacceptance, though the underlying reasons may be varied. PMID: 32977110 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - September 21, 2020 Category: Neurology Authors: Chawla A, Singh G, Sharma S, Bansal R, Bansal N, Chowdhury A, Paul BS, Sharma S, Sander JW Tags: Epilepsy Behav Source Type: research

Electroencephalographic findings in antileucine-rich glioma-inactivated 1 (LGI1) autoimmune encephalitis: A systematic review.
CONCLUSION: Electroencephalogram abnormalities are seen in anti-LGI1 autoimmune encephalitis with epileptiform discharges as the most common finding followed by focal slowing. These findings were most frequently seen arising in the temporal region. Further studies using a standardized protocol focusing on electroencephalographic findings in anti-LGI1 encephalitis with clinical correlation to disease stage and treatment outcomes in terms of seizure control and memory and cognitive function are needed. Particular attention on ictal electrodecremental activity during FBDS should be done in studies with a larger sample size. ...
Source: Epilepsy and Behaviour - September 20, 2020 Category: Neurology Authors: Roberto KT, Espiritu AI, Fernandez MLL, Gutierrez JC Tags: Epilepsy Behav Source Type: research

The perceived health of children with epilepsy, sense of control, and support for their families.
kar D Abstract AIM: The aim of this study was to evaluate the perceived health of children with epilepsy as experienced by the respondents to a questionnaire, to assess the sense of control over their child's epilepsy, and how much support they feel they received in various environments. METHODS: In this observational study, the data were collected using a questionnaire that was sent to families of children with epilepsy, who were treated at University Children's Hospital in Ljubljana, Slovenia from January to September 2016. The questionnaire consisted of 29 questions related to their epilepsy. RESULTS:...
Source: Epilepsy and Behaviour - September 20, 2020 Category: Neurology Authors: Vrščaj E, Perković Benedik M, Oražem Mrak J, Bizjak N, Osredkar D Tags: Epilepsy Behav Source Type: research

Barriers to biomedical care for people with epilepsy in Uganda: A cross-sectional study.
CONCLUSIONS: People with repetitive seizures in Uganda report several barriers to obtaining biomedical care in Uganda, with those related to practical and actual costs endorsed the most. It is imperative that interventions developed to reduce the TG in Uganda consider these practical issues to improve access to effective epilepsy care. This article is part of the Special Issue "The Intersection of Culture, Resources, and Disease: Epilepsy Care in Uganda. PMID: 32962922 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - September 18, 2020 Category: Neurology Authors: Kaddumukasa MN, Kaddumukasa M, Kajumba M, Smith PJ, Bobholz S, Kakooza-Mwesige A, Sinha DD, Almojuela A, Chakraborty P, Nakasujja N, Nakku J, Gualtieri A, Onuoha E, Kolls BJ, Muhumuza C, Smith CE, Sanchez N, Fuller AT, Haglund MM, Koltai DC Tags: Epilepsy Behav Source Type: research

Incremental burden of mental health conditions in adult patients with focal seizures.
Abstract INTRODUCTION: Clinical research has consistently established mental health conditions (MHCs) as frequent comorbidities of epilepsy. However, the extent of economic burden of comorbid MHC in patients with focal seizures has not been systematically investigated. This retrospective cohort analysis of health plan claims compared healthcare use and costs among adult patients with focal seizures with and without comorbid MHC. METHODS: We utilized the Inovalon Medical Outcomes Research for Effectiveness and Economics (MORE2) Registry, longitudinal data from over 150 commercial, Medicare Advantage, and manag...
Source: Epilepsy and Behaviour - September 18, 2020 Category: Neurology Authors: Petrilla AA, Sutton BS, Leinwand BI, Parente A, Ferrari L, Wade CT Tags: Epilepsy Behav Source Type: research

Quality of life in elderly patients after surgery for drug-resistant epilepsy - The impact of seizure outcome, neurological deficits and anxiety.
Abstract INTRODUCTION: Health related quality of life (HRQoL) has become a pivotal outcome parameter after surgery for drug-resistant epilepsy. The aim of the study was to investigate HRQoL and its relationship to seizure outcome, neurological deficits and anxiety after epilepsy surgery in a specific subpopulation of elderly patients. METHODS: A total of 85 elderly patients (older than 50 years) answered a standardized HRQoL questionnaire one year after epilepsy surgery. The questionnaire addressed the present self-assessed HRQoL in four subdomains (physical function, cognitive function, mood, social intera...
Source: Epilepsy and Behaviour - September 17, 2020 Category: Neurology Authors: Delev D, Hakvoort K, Grote A, Neuloh G, Clusmann H, von Lehe M Tags: Epilepsy Behav Source Type: research

Contemporary relationship between medical expenditures and quality of life among adults with epilepsy in the United States.
CONCLUSION: Quality of life and OOP health expenditures are independently and inversely related to each other among adults with epilepsy. Over the decade studied in the United States, there was a decrease in OOP health expenditures among those patients with epilepsy with the lowest QoL, possibly reflecting a rise in insurance coverage after the Affordable Care Act. PMID: 32956943 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - September 17, 2020 Category: Neurology Authors: Lekoubou A, Pelton M, Bishu KG, Ovbiagele B Tags: Epilepsy Behav Source Type: research

Current legal status of medical marijuana and cannabidiol in the United States.
Abstract In the United States, access to marijuana and its related products has been outlawed since passing the Controlled Substance Act (CSA) in 1970. Under this act, marijuana is classified as Schedule I substance and is considered to have a high potential for dependency and abuse as well as unaccepted medical use. From that time, multiple states have taken measures to legalize and decriminalize the use of marijuana. In June 2018, Epidiolex® (cannabidiol, CBD) was the first cannabis-derived drug approved by the U.S. Food and Drug Administration (FDA) for the treatment of severe forms of epilepsy, Lennox-Gast...
Source: Epilepsy and Behaviour - September 17, 2020 Category: Neurology Authors: Alharbi YN Tags: Epilepsy Behav Source Type: research

Physical exercise and 5-hydroxytryptophan, a precursor for serotonin synthesis, reduce penicillin-induced epileptiform activity.
CONCLUSIONS: It was determined that exercise reduced the spike number and delayed seizure significantly by potentiating the effect of 5-HTP. Given that 5-HTP used in combination with exercise can perform useful actions such as reducing seizure sensitivity and consequently improving the quality of life for individuals with epilepsy, it may be a potential candidate for the treatment of epilepsy in nonpharmacological methods. PMID: 32950765 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - September 16, 2020 Category: Neurology Authors: Kayacan Y, Ghojebeigloo BE, Çerit G, Kocacan SE, Ayyıldız M Tags: Epilepsy Behav Source Type: research

Enzyme-inducing antiseizure medication utilization in patients with epilepsy and vascular risk factors.
CONCLUSIONS: A substantial proportion of patients with comorbid vascular disease or vascular risk factors (e.g., hypertension and older age) is prescribed EIASMs. This could potentially increase patients' risk for subsequent negative outcomes such as cardiovascular or cerebrovascular disease. Though utilization of these medications has decreased, further efforts toward increasing use of newer antiseizure medications (ASMs) that are not associated with similar risks may be warranted. PMID: 32950766 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - September 16, 2020 Category: Neurology Authors: Fox J, Ajinkya S, Lekoubou A Tags: Epilepsy Behav Source Type: research

Marital status in patients with functional (psychogenic nonepileptic) seizures: An international study.
CONCLUSION: The marital status has significant associations with the semiology of functional seizures. A history of sexual abuse is significantly associated with being separated and should be inquired and tackled appropriately during the management process of patients with functional seizures. PMID: 32950767 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - September 16, 2020 Category: Neurology Authors: Asadi-Pooya AA, Mesraoua B, Hingray C, Gigineishvili D, Karakis I, Hosny H, Alsaadi T, Melikyan G, Janocko NJ, Thekkumpurath T, Tarrada A, Lattanzi S, Brigo F Tags: Epilepsy Behav Source Type: research

Atypical language representation as a protective factor against verbal memory decline following epilepsy surgery.
CONCLUSION: Patients with atypical language dominance had better verbal memory outcomes following left hemisphere resections than those with left hemisphere language dominance suggesting that typical memory substrates likely reorganized along with language. Thus, atypical cerebral organization of language may be considered a protective factor against verbal memory decline following epilepsy surgery involving the left TL. PMID: 32956944 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - September 16, 2020 Category: Neurology Authors: Fatoorechi S, Westerveld M, Lee GP Tags: Epilepsy Behav Source Type: research

Spectral power of interictal EEG in the diagnosis and prognosis of idiopathic generalized epilepsies.
CONCLUSIONS: Electroencephalography spectral power analysis could form part of a clinically useful diagnostic biomarker for IGE; however, it did not correlate with response to AED in this study. PMID: 32949965 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - September 15, 2020 Category: Neurology Authors: Pegg EJ, Taylor JR, Mohanraj R Tags: Epilepsy Behav Source Type: research

Incidence of anxiety in epilepsy during coronavirus disease (COVID-19) pandemic.
CONCLUSION: Although still many aspects of the pandemic on people with epilepsy are yet to be determined, active investigation of psychological sequels of the pandemic is demanded. PMID: 32949966 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - September 15, 2020 Category: Neurology Authors: Salari M, Etemadifar M, Gharagozli K, Etemad K, Ashrafi F, Ashourizadeh H Tags: Epilepsy Behav Source Type: research

Quality of life in patients with epilepsy or psychogenic nonepileptic seizures and the contribution of psychiatric comorbidities.
CONCLUSION: Nonepileptic seizures have an even greater impact on QoL than epileptic seizures, and this could be influenced by psychiatric comorbidities. These findings corroborate what other studies in English-speaking nations that have found regarding the impact of psychopathology on QoL in those with PNES and further support the importance of assessing for psychiatric comorbidities to tailor treatment. PMID: 32947249 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - September 14, 2020 Category: Neurology Authors: Avalos JC, Silva BA, Tevés Echazu MF, Rosso B, Besocke AG, Del Carmen Garcia M Tags: Epilepsy Behav Source Type: research

Depression, sleep quality, and social isolation among people with epilepsy in Bhutan: A cross-sectional study.
CONCLUSIONS: Our exploratory study disentangles the multilayered psychosocial burden of disease experienced by PWE in Bhutan, a lower-middle-income country with access to antiseizure medications and psychiatrists but not expert epilepsy services or human resources. Further investigation into the interrelationships among social isolation, poor sleep quality, depression, and seizure burden could identify preventable and remediable constituents of this burden. PMID: 32947250 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - September 14, 2020 Category: Neurology Authors: Stauder M, Vogel AC, Nirola DK, Tshering L, Dema U, Dorji C, Dorji L, Mateen FJ, Bhutan Epilepsy Project Tags: Epilepsy Behav Source Type: research

Safety, tolerability, and pharmacokinetics of weight-based IV loading dose of lacosamide in the ICU.
Abstract Among the newer antiseizure medications, lacosamide (LCM) has been increasingly used for acute seizures and status epilepticus in intensive care unit (ICU). We reviewed retrospectively weight-based dosing of IV LCM in patients admitted to ICU with acute seizures and status epilepticus. We have analyzed 354/382 patient treated with IV LCM in ICU during the years 2013-2016. Data collected were age, total body weight, body mass index (BMI), loading dose, post-IV infusion LCM blood level, duration of infusion, blood pressure, heart rate, oxygen saturation, mean arterial pressures, and documented initiation of...
Source: Epilepsy and Behaviour - September 13, 2020 Category: Neurology Authors: Chimakurthy AK, Ramsay RE, Sabharwal V, Menon U Tags: Epilepsy Behav Source Type: research

Understanding the cultural context of epilepsy care in Uganda: Introduction to this special issue.
This article is part of the Special Issue "The Intersection of Culture, Resources, and Disease: Epilepsy Care in Uganda". PMID: 32943332 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - September 13, 2020 Category: Neurology Authors: Koltai DC, Kakooza-Mwesige A, Haglund MM Tags: Epilepsy Behav Source Type: research

Efficacy of vagus nerve stimulation for drug-resistant epilepsy in children age six and younger.
This study demonstrates the safety and efficacy of VNS for children with drug-resistant epilepsy (DRE) younger than six. One, two, and four years after VNS implantation, 55%, 60%, and 52% of these patients, respectively, achieved ≥50% reduction in seizure frequency. The safety of VNS is also comparable with older, better studied, age groups. Based on these data, VNS therapy should be considered for children younger than six. PMID: 32942207 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - September 13, 2020 Category: Neurology Authors: Muthiah N, Zhang J, Remick M, Welch W, Sogawa Y, Jeong JH, Abel TJ Tags: Epilepsy Behav Source Type: research

Telehealth perceptions in patients with epilepsy and providers during the COVID-19 pandemic.
Abstract Coronavirus disease 2019 (COVID-19) has required novel solutions for issues that arise with social distancing. Telehealth has become one of those solutions in many clinics around the U.S. As we look beyond, the pandemic telehealth can be utilized as an important tool for clinics in the future. Patient satisfaction will most likely affect reimbursement, while provider perception will affect implementation. We see this as a valuable tool to many epilepsy clinics. The goal of our survey was to determine the perceptions and satisfaction of patients with intractable epilepsy and providers with telehealth durin...
Source: Epilepsy and Behaviour - September 11, 2020 Category: Neurology Authors: Casares M, Wombles C, Skinner HJ, Westerveld M, Gireesh ED Tags: Epilepsy Behav Source Type: research

Access to healthcare and prevalence of anxiety and depression in persons with epilepsy during the COVID-19 pandemic: A multicountry online survey.
CONCLUSIONS: Innovative approaches are needed to ensure continuity in access to ASM treatment. Healthcare workers should ensure continued follow-up, either through inperson or telehealth appointments, to timely identify symptoms of anxiety and depression and act accordingly. PMID: 32920373 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - September 9, 2020 Category: Neurology Authors: Van Hees S, Siewe Fodjo JN, Wijtvliet V, Van den Bergh R, Faria de Moura Villela E, da Silva CF, Weckhuysen S, Colebunders R Tags: Epilepsy Behav Source Type: research

Alterations of functional connectivity density in a Chinese family with a mild phenotype associated with a novel inherited variant of SCN8A.
CONCLUSIONS: We identified a novel SCN8A variant with a mild familial epilepsy phenotype. A similar pattern of FCD alterations in patients and their unaffected siblings might represent an endophenotype of benign epilepsy associated with the SCN8A inherited variant, and more extensive alterations in mesial frontal regions may help us to further understand the pathogenesis of SCN8A-related mild epilepsy. PMID: 32920374 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - September 9, 2020 Category: Neurology Authors: Zhu Q, Jiang S, Luo C, Yang J, Yu L Tags: Epilepsy Behav Source Type: research

Visual illustration supporting patient-physician communication in epilepsy: A validation and reliability study of seizure images.
Abstract Seizure manifestations may be difficult to describe in words alone. Thus, initially, 24 seizure images were developed to support communication and gain assistance during obtaining the patient's history. Before being used in clinical practice, these seizure images must be investigated for validity and reliability. We tested the images with untrained participants including patients with epilepsy, persons who had witnessed seizures, and participants who had neither had nor witnessed epileptic seizures. The participants filled in a questionnaire evaluating the images twice within 3 days. The participants we...
Source: Epilepsy and Behaviour - September 9, 2020 Category: Neurology Authors: Intravooth T, Steinhoff BJ, Staack AM, Wendling AS, Stockinger J, Tanezer A, Oehl B Tags: Epilepsy Behav Source Type: research

Evaluation of pediatric patients in new-onset seizure clinic (NOSc).
Abstract AIM: We evaluated the clinical and demographic features of children presenting with unprovoked seizures at a regional new-onset seizure clinic (NOSc). METHODS: We retrospectively reviewed charts of 492 consecutive patients evaluated in the NOSc at the Childrne's Healthcare of Atlanta RESULTS: Nonepileptic events (NEE) were diagnosed in 102 (24%) and epileptic seizures in the remaining 326 (76%). Patients with NEE were younger than patients with epileptic seizure (5.0 vs. 7.4 years). Except for headache which occurred more frequently in NEE (14% vs. 6%), frequencies of comorbidities were similar in ...
Source: Epilepsy and Behaviour - September 9, 2020 Category: Neurology Authors: Kim S, DeGrauw T, Berg AT, Hass KB, Koh S Tags: Epilepsy Behav Source Type: research

Epilepsy-associated neurocognitive disorders (EAND) in an onchocerciasis-endemic rural community in Cameroon: A population-based case-control study.
This study was thus designed to assess cognitive impairment in PWE or epilepsy-associated neurocognitive disorders (EAND) in a rural population in Cameroon. METHODS: This was a case-control study including PWE and age/sex-matched healthy controls from July to September 2017 in Bilomo, a village in the Mbam and Kim Division. The Montreal Cognitive Assessment (MoCA), International HIV Dementia Scale (IHDS), Dubois' Five Word testing, Frontal Assessment Battery (FAB), Isaac's Set Test and the Clock drawing test were administered to the study participants to evaluate global and specific cognitive functions. RESULTS: ...
Source: Epilepsy and Behaviour - September 9, 2020 Category: Neurology Authors: Njamnshi AK, Chokote ES, Ngarka L, Nfor LN, Tabah EN, Atchou JGB, Angwafor SA, Nkouonlack C, Mengnjo MK, Njamnshi WY, Dema F, Tatah GY, Zoung-KanyiBissek AC, Annoni JM, Ruffieux N Tags: Epilepsy Behav Source Type: research

Genetic testing and the phenotype of Polish patients with Unverricht-Lundborg disease (EPM1) - A cohort study.
CONCLUSIONS AND CLINICAL IMPLICATIONS: Genetic findings and the clinical picture of our patients with ULD were in accordance with available studies. The most common genetic defect underlying ULD was homozygosity for an unstable expansion of a dodecamer repeat in the CSTB gene. Patients with action or/and stimulus sensitive myoclonus or intractable myoclonus epilepsy, especially with onset in late childhood/adolescence should be screened for ULD. PMID: 32920378 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - September 9, 2020 Category: Neurology Authors: Bosak M, Sułek A, Łukasik M, Żak A, Słowik A, Lasek-Bal A Tags: Epilepsy Behav Source Type: research

Cognitive, adaptive, and behavioral effects of adjunctive rufinamide in Lennox-Gastaut syndrome: A prospective observational clinical study.
CONCLUSION: Adjunctive treatment with RFM did not negatively affect cognitive, adaptive function, and emotional profile in patients with LGS after 1 year of follow-up. PMID: 32920379 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - September 9, 2020 Category: Neurology Authors: Operto FF, Verrotti A, Marrelli A, Ciuffini R, Coppola G, Pastorino GMG, Striano P, Sole M, Zucca C, Manfredi V, Città S, Elia M Tags: Epilepsy Behav Source Type: research

Examination of the Flynn effect in German patients with epilepsy assessed with the Wechsler Adult Intelligence Scale (WAIS) III and IV.
e S Abstract The Flynn effect describes an increase in intelligence quotient (IQ) in the general population of about 3 points per decade. While this effect is well established in healthy individuals, research exploring the link to brain pathologies is scarce. We investigated the Flynn effect in a German sample of 203 patients with epilepsy with left, right, and bilateral lesions. Intelligence quotient values were obtained using the Wechsler Adult Intelligence Scales (WAIS) III and IV. Our results showed a stable Flynn effect with nearly no difference in adjusted full scale IQ (FSIQ) scores (0.02 IQ points) between...
Source: Epilepsy and Behaviour - September 8, 2020 Category: Neurology Authors: Mross PM, Gorny I, Krause K, Biermann L, Habermehl L, Möller L, Bergmann MP, Tsalouchidou PE, Laakmann JD, Weyand AM, Menzler K, Knake S Tags: Epilepsy Behav Source Type: research

Brain-responsive corticothalamic stimulation in the centromedian nucleus for the treatment of regional neocortical epilepsy.
CONCLUSION: In this small series of patients with medically intractable focal seizures and regional neocortical onset, responsive neurostimulation to the neocortex and CMT improved seizure control and was well tolerated. SIGNIFICANCE: Responsive corticothalamic neurostimulation of the CMT and neocortex is a potential treatment for patients with regional neocortical epilepsies. PMID: 32919199 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - September 8, 2020 Category: Neurology Authors: Burdette DE, Haykal MA, Jarosiewicz B, Fabris RR, Heredia G, Elisevich K, Patra SE Tags: Epilepsy Behav Source Type: research

Baseline neuropsychological characteristics in patients with epilepsy with left temporal lobe encephaloceles compared with left mesial temporal sclerosis.
CONCLUSIONS: This pilot study demonstrates few significant differences between the groups with left MTS and TE surveyed. A higher rate of atypical language lateralization was noted in patients with left MTS. The higher baseline global IQ and VCI scores in patients with left TE compared with patients with MTS may be attributable to longer duration of epilepsy in patients with left MTS. Future work with a larger sample size will focus on establishing a unique neuropsychological profile related to epilepsy due to TE. PMID: 32919200 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - September 8, 2020 Category: Neurology Authors: Samudra N, Jacobs M, Aulino JM, Abou-Khalil B Tags: Epilepsy Behav Source Type: research

Cognitive task-related functional connectivity alterations in temporal lobe epilepsy.
aron; P, Rektor I Abstract OBJECTIVE: We investigated cognitive task-related functional connectivity (FC) in patients with temporal lobe epilepsy (TLE). Using a visual three-stimulus paradigm (VTSP), we studied cognitive large-scale networks and the impact of TLE on connectivity outside the temporal lobe. METHODS: High-density electroencephalography (EEG) was recorded during the paradigm from nineteen patients with epilepsy with hippocampal sclerosis (HS) and ten healthy controls (HCs). Scalp data were reconstructed into the source space, and FC was computed. Correlating with the neuropsychological data, poss...
Source: Epilepsy and Behaviour - September 8, 2020 Category: Neurology Authors: Strýček O, Lamoš M, Klimeš P, Rektor I Tags: Epilepsy Behav Source Type: research

Disability in people with epilepsy: A nationally representative cross-sectional study.
We report the prevalence of any limitation and total number of limitations for participants without vs. with epilepsy using serial negative binomial regressions and severity of individual limitations according to epilepsy status. RESULTS: We included 17,057 participants, of whom 148 (0.8%) had epilepsy. Overall, 80% (95% confidence interval [CI]: 73%-86%) with epilepsy vs. 38% (95% CI: 36%-39%) without epilepsy reported at least 1 limitation (p 
Source: Epilepsy and Behaviour - September 8, 2020 Category: Neurology Authors: Terman SW, Hill CE, Burke JF Tags: Epilepsy Behav Source Type: research

Blunted neural response to emotional faces in the fusiform and superior temporal gyrus may be marker of emotion recognition deficits in pediatric epilepsy.
Abstract Individuals with epilepsy are at risk for social cognition deficits, including impairments in the ability to recognize nonverbal cues of emotion (i.e., emotion recognition [ER] skills). Such deficits are particularly pronounced in adult patients with childhood-onset seizures and are already evident in children and adolescents with epilepsy. Though these impairments have been linked to blunted neural response to emotional information in faces in adult patients, little is known about the neural correlates of ER deficits in youth with epilepsy. The current study compared ER accuracy and neural response to em...
Source: Epilepsy and Behaviour - September 8, 2020 Category: Neurology Authors: Morningstar M, Hung A, Grannis C, French RC, Mattson WI, Ostendorf AP, Gedela S, Englot DJ, Nelson EE Tags: Epilepsy Behav Source Type: research

Clinical characteristics and outcomes in pregnant women with epilepsy.
Abstract BACKGROUND: Epilepsy in pregnancy can lead to substantial maternal and neonatal morbidity and mortality. Early intervention in pregnant women with epilepsy (WWE), accurate assessment of the severity of their condition, and effective treatment are required to improve maternal and neonatal prognosis. Many obstetricians lack experience in monitoring and treating pregnant WWE. AIMS: The aim of this study was to describe the demographic and clinical characteristics of pregnant WWE and examine maternal and neonatal outcomes. METHODS: Medical records of 75 pregnant women with a history of epilepsy who ...
Source: Epilepsy and Behaviour - September 8, 2020 Category: Neurology Authors: Huang CY, Dai YM, Feng LM, Gao WL Tags: Epilepsy Behav Source Type: research

Family cohesion is differently associated with felt stigma depending on enacted stigma in adults with epilepsy.
CONCLUSIONS: Family functioning especially family cohesion may have protective effects against development of felt stigma in adults with epilepsy. Such protecting effects against felt stigma may be different according to enacted stigma. This understanding is helpful for developing effective psychosocial interventions to reduce felt stigma in patients with epilepsy. PMID: 32919205 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - September 8, 2020 Category: Neurology Authors: Lee SA, Kim SJ, Kim HJ, Lee JY, Kim MK, Heo K, Kim WJ, Cho YJ, Ji KW, Park KI, Kim KK, Lee EM Tags: Epilepsy Behav Source Type: research

Statins in primary prevention of poststroke seizures and epilepsy: A systematic review.
CONCLUSIONS: Data from the literature suggest an association between statin use and a reduced risk of ASPSS after ischemic stroke and a reduced risk of PSE after ischemic and hemorrhagic stroke. Although the certainty of the evidence is low, these findings appear promising and worthy of further investigation. PMID: 32916580 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - September 7, 2020 Category: Neurology Authors: Nucera B, Rinaldi F, Nardone R, Lattanzi S, Brigo F Tags: Epilepsy Behav Source Type: research

Ictal central apneas in temporal lobe epilepsies.
CONCLUSIONS: In a selective cohort of TLE defined by MRI lesion and/or intracranial recordings, the frequency of ICA was higher than previously reported in the literature. Multimodal respiratory monitoring has localizing value and is generally well tolerated. Ictal central apnea preceded both EEG on scalp recordings as well as clinical seizure onset in a substantial number of patients. Respiratory monitoring and ICA detection is even more paramount during invasive monitoring to confirm that the recorded seizure onset is seen before the first clinical sign. PMID: 32916581 [PubMed - as supplied by publisher] (Source: Ep...
Source: Epilepsy and Behaviour - September 7, 2020 Category: Neurology Authors: Tio E, Culler GW, Bachman EM, Schuele S Tags: Epilepsy Behav Source Type: research

Subtemporal selective amygdalohippocampectomy in patients with mesial temporal lobe epilepsy: Systematic review of seizure and neuropsychological outcomes.
Abstract In addition to standard anterior temporal lobectomy (ATL), subtemporal selective amygdalohippocampectomy (sSAH) is also a common technique for the treatment of medically intractable mesial temporal lobe epilepsy (MTLE). We conducted a systematic literature review to determine the seizure and neuropsychological outcomes in patients with MTLE who underwent sSAH. We searched PubMed and Embase using Medical Subject Headings and keywords related to sSAH, seizure outcome, and neuropsychological outcome. Titles, abstracts, and full-texts were screened in light of inclusion and exclusion criteria that were establ...
Source: Epilepsy and Behaviour - September 7, 2020 Category: Neurology Authors: Yue J, Zhang CQ, Hou Z, Yang H Tags: Epilepsy Behav Source Type: research

ADHD and ADHD-related neural networks in benign epilepsy with centrotemporal spikes: A systematic review.
CONCLUSIONS: Despite BECTS being considered to have a relative benign course, many studies have documented cognitive and/or behavioral problems in patients diagnosed with this type of epilepsy. In particular, children affected by rolandic epilepsy should receive a complete neuropsychological evaluation at seizure onset considering the high rate of comorbidity with ADHD. A further investigation of the common pathogenic substrate is desirable to better orientate the clinical and therapeutic interventions applied. PMID: 32916583 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - September 7, 2020 Category: Neurology Authors: Aricò M, Arigliani E, Giannotti F, Romani M Tags: Epilepsy Behav Source Type: research

Emergent neuroimaging for seizures in epilepsy: A population study.
Abstract We determined how often patients with epilepsy presented to the emergency department (ED) for seizure and the frequency and predictors for undergoing emergent neuroimaging during those visits. We conducted a retrospective population-based cohort study using administrative claims' data from 2007 to 2015. Adults with epilepsy were identified based on a diagnosis of epilepsy and an outpatient prescription for an antiepileptic medication. The Bonferroni corrected significance level was 0.0018. We identified 381,362 patients with a mean follow-up period of 1.99 years, of whom 35,015 (9.2%) patients presented...
Source: Epilepsy and Behaviour - September 6, 2020 Category: Neurology Authors: Lamsam L, Bhambhvani HP, Ratliff JK, Kvam KA Tags: Epilepsy Behav Source Type: research

The association of cognitive phenotypes with postoperative outcomes after epilepsy surgery in patients with temporal lobe epilepsy.
CONCLUSIONS: Distinct cognitive phenotypes in TLE can be identified using clinical criteria and may reflect neurodevelopmental influences and mood in addition to progression of the disease. Phenotype may be a more powerful predictor of postoperative decline in visual memory than laterality of surgery. PMID: 32911298 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - September 6, 2020 Category: Neurology Authors: Baxendale S, Thompson P Tags: Epilepsy Behav Source Type: research

Influence of the COVID-19 outbreak in people with epilepsy: Analysis of a Spanish population (EPICOVID registry).
CONCLUSIONS: A high proportion of PWE suffered a significant worsening of their seizure control during the months of the COVID-19 pandemic. Emotional distress due to home confinement was the main factor for the change in seizure control. Promoting physical activity and adequate sleep may minimize the potential impact of the pandemic in PWE. Ensuring correct follow-up can prevent decompensation in those PWE at high risk. PMID: 32911299 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - September 6, 2020 Category: Neurology Authors: Sanchez-Larsen A, Gonzalez-Villar E, Díaz-Maroto I, Layos-Romero A, Martínez-Martín Á, Alcahut-Rodriguez C, Grande-Martin A, Sopelana-Garay D Tags: Epilepsy Behav Source Type: research

Seizure outcome with responsive neurostimulation (RNS) comparing strip versus depth leads.
CONCLUSION: In our small retrospective population, patients with RNS strip leads experienced a significantly greater seizure reduction than patients with RNS depth leads, without a difference in complication rate. PMID: 32911300 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - September 6, 2020 Category: Neurology Authors: Drees C, McDermott D, Sillau S, Abosch A, Ojemann S, Brown MG Tags: Epilepsy Behav Source Type: research