Duration of nonconvulsive seizures in critically ill patients
Epilepsy Behav. 2021 Sep 22;124:108312. doi: 10.1016/j.yebeh.2021.108312. Online ahead of print.ABSTRACTINTRODUCTION: Non-convulsive seizures (NCSz) and non-convulsive status epilepticus (NCSE) are frequent in critically ill patients. Specific temporal thresholds to define both are lacking and may be needed to guide appropriate treatment.METHOD: Retrospective review of 995 NCSz captured during continuous EEG monitoring of 111 consecutive critically ill patients. Seizures were classified according to their type and underlying etiology (acute or progressive brain injury, seizure-related disorders and acute medical illness). ...
Source: Epilepsy and Behaviour - September 25, 2021 Category: Neurology Authors: Charlotte Damien Fode Abbas Ciss é Chantal Depondt Estelle Rikir Benjamin Legros Nicolas Gaspard Source Type: research

Seizure frequency, quality of life, behavior, cognition, and sleep in pediatric patients enrolled in a prospective, open-label clinical study with cannabidiol
Epilepsy Behav. 2021 Sep 21;124:108325. doi: 10.1016/j.yebeh.2021.108325. Online ahead of print.ABSTRACTOBJECTIVE: To evaluate the effects of oral pharmacological cannabidiol (CBD) on seizures, side effects, quality of life, behavior, mood, and sleep in children with drug-resistant epilepsy (DRE) during a phase II, prospective, open-label clinical study.METHODS: During a phase II expanded access program (EAP) study to evaluate the safety and efficacy of using cannabidiol (CBD) for the long-term treatment of children with drug-resistant epilepsy, secondary outcome measures were also performed, including quality of life (QOL...
Source: Epilepsy and Behaviour - September 24, 2021 Category: Neurology Authors: Christopher L Anderson Victoria Evans Laura Gorham Zhao Liu Cynthia R Johnson Paul R Carney Source Type: research

Sex differences in seizure effects on social anxiety in persons with epilepsy
CONCLUSION: We found significant sex differences in seizure effects on social anxiety. Intractable seizures were associated with social phobia in men, whereas lack of seizure freedom in the last year was associated with social interaction anxiety in women.PMID:34560359 | DOI:10.1016/j.yebeh.2021.108318 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - September 24, 2021 Category: Neurology Authors: Sang-Ahm Lee Yang-Je Cho Han Uk Ryu Keun Tae Kim Jong-Geun Seo Kyung Wook Kang Ji Eun Kim Young-Soo Kim Jung Bin Kim Kyoung Jin Hwang Su-Hyun Han Gha-Hyun Lee Dong Jin Shin Jee Hyun Kim Seo-Young Lee Source Type: research

Process-oriented and personalized psychotherapeutic care for epilepsy: Interim results of a feasibility study
CONCLUSION: The results suggest that process-oriented and personalized psychotherapeutic has low attrition and results in improved quality of life and reduced psychiatric symptoms in people with epilepsy. Our findings indicate that responsiveness to psychotherapy is not dependent on the number of attended treatment sessions. Participants with childhood trauma did not need more treatment sessions to achieve an improvement. More research is needed to understand and address mechanisms and precursors of responsiveness to psychotherapy.PMID:34560360 | DOI:10.1016/j.yebeh.2021.108313 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - September 24, 2021 Category: Neurology Authors: Rosa Michaelis G ünter Schiepek Gerd Maria Heinen Friedrich Edelh äuser Kathrin Viol Source Type: research

Association between telemedicine and incidence of status epilepticus during the COVID-19 pandemic
Epilepsy Behav. 2021 Sep 20;124:108303. doi: 10.1016/j.yebeh.2021.108303. Online ahead of print.ABSTRACTOBJECTIVE: We aimed to investigate the association between telemedicine and the incidence of status epilepticus (SE) in patients with epilepsy (PWE) during the coronavirus disease 2019 (COVID-19) pandemic using a large population database in the United States.METHODS: We performed a retrospective analysis of a private, cloud-based healthcare platform (Explorys Inc., Cleveland, Ohio, USA). We compared each of the previously reported risk factors for SE, such as child, male, and refractory epilepsy, using the chi-square te...
Source: Epilepsy and Behaviour - September 23, 2021 Category: Neurology Authors: Takafumi Kubota Naoto Kuroda Source Type: research

Association between telemedicine and incidence of status epilepticus during the COVID-19 pandemic
Epilepsy Behav. 2021 Sep 20;124:108303. doi: 10.1016/j.yebeh.2021.108303. Online ahead of print.ABSTRACTOBJECTIVE: We aimed to investigate the association between telemedicine and the incidence of status epilepticus (SE) in patients with epilepsy (PWE) during the coronavirus disease 2019 (COVID-19) pandemic using a large population database in the United States.METHODS: We performed a retrospective analysis of a private, cloud-based healthcare platform (Explorys Inc., Cleveland, Ohio, USA). We compared each of the previously reported risk factors for SE, such as child, male, and refractory epilepsy, using the chi-square te...
Source: Epilepsy and Behaviour - September 23, 2021 Category: Neurology Authors: Takafumi Kubota Naoto Kuroda Source Type: research

Altered functional connectivity in newly diagnosed benign epilepsy with unilateral or bilateral centrotemporal spikes: A multi-frequency MEG study
CONCLUSION: The findings revealed that children with BECTS display a diffuse early cognitive deficit. In addition, resting-state suboptimal network topology may be the mechanism of cognitive impairment in children with BECTS. The study also showed that and children with B-BECTS may be at a higher risk of cognitive impairment.PMID:34547687 | DOI:10.1016/j.yebeh.2021.108276 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - September 21, 2021 Category: Neurology Authors: Pengfei Wang Yihan Li Yulei Sun Jingtao Sun Kai Niu Ke Zhang Jing Xiang Qiqi Chen Zheng Hu Xiaoshan Wang Source Type: research

Altered functional connectivity in newly diagnosed benign epilepsy with unilateral or bilateral centrotemporal spikes: A multi-frequency MEG study
CONCLUSION: The findings revealed that children with BECTS display a diffuse early cognitive deficit. In addition, resting-state suboptimal network topology may be the mechanism of cognitive impairment in children with BECTS. The study also showed that and children with B-BECTS may be at a higher risk of cognitive impairment.PMID:34547687 | DOI:10.1016/j.yebeh.2021.108276 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - September 21, 2021 Category: Neurology Authors: Pengfei Wang Yihan Li Yulei Sun Jingtao Sun Kai Niu Ke Zhang Jing Xiang Qiqi Chen Zheng Hu Xiaoshan Wang Source Type: research

Pediatric hemispherectomy outcome: Adaptive functioning, intelligence, and memory
This study is unique for cohort size, intelligence plus memory testing, and evidence of primacy of verbal over visual-spatial development, despite hemispherectomy side. This study reinforces the role of hemispherectomy in achieving good seizure outcome while preserving functioning.PMID:34537627 | DOI:10.1016/j.yebeh.2021.108298 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - September 19, 2021 Category: Neurology Authors: Hillary A Shurtleff Emma A Roberts Christopher C Young Dwight Barry Mary H Warner Russell P Saneto Robert Buckley Timothy Firman Andrew V Poliakov Richard G Ellenbogen Jason S Hauptman Jeffrey G Ojemann Ahmad Marashly Source Type: research

Pediatric hemispherectomy outcome: Adaptive functioning, intelligence, and memory
This study is unique for cohort size, intelligence plus memory testing, and evidence of primacy of verbal over visual-spatial development, despite hemispherectomy side. This study reinforces the role of hemispherectomy in achieving good seizure outcome while preserving functioning.PMID:34537627 | DOI:10.1016/j.yebeh.2021.108298 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - September 19, 2021 Category: Neurology Authors: Hillary A Shurtleff Emma A Roberts Christopher C Young Dwight Barry Mary H Warner Russell P Saneto Robert Buckley Timothy Firman Andrew V Poliakov Richard G Ellenbogen Jason S Hauptman Jeffrey G Ojemann Ahmad Marashly Source Type: research

Pediatric hemispherectomy outcome: Adaptive functioning, intelligence, and memory
This study is unique for cohort size, intelligence plus memory testing, and evidence of primacy of verbal over visual-spatial development, despite hemispherectomy side. This study reinforces the role of hemispherectomy in achieving good seizure outcome while preserving functioning.PMID:34537627 | DOI:10.1016/j.yebeh.2021.108298 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - September 19, 2021 Category: Neurology Authors: Hillary A Shurtleff Emma A Roberts Christopher C Young Dwight Barry Mary H Warner Russell P Saneto Robert Buckley Timothy Firman Andrew V Poliakov Richard G Ellenbogen Jason S Hauptman Jeffrey G Ojemann Ahmad Marashly Source Type: research

Reading and the visual word form area (VWFA) - Management and clinical experience at one epilepsy surgery center
We present evidence on the functional relevance of the vOTC for reading by (1) extra-operative cortical stimulation of the VWFA and by (2) a retrospective case study of reading deficits in patients operated in this area. Reading assessments and data concerning essential reading structures should be included in the presurgical evaluation of patients with lesions in the left vOTC.PMID:34536734 | DOI:10.1016/j.yebeh.2021.108274 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - September 18, 2021 Category: Neurology Authors: Thomas Cloppenborg Markus Mertens Johanna L Hopf Thilo Kalbhenn Christian G Bien Friedrich G Woermann Tilman Polster Source Type: research

The impact of SARS-CoV-2 vaccination in Dravet syndrome: A UK survey
CONCLUSION: Overall, these results suggest that SARS-CoV-2 vaccines are safe and well tolerated in individuals with DS, as they are in most people without DS. In most people with DS, SARS-CoV-2 vaccine does not appear to be associated with an increase in the frequency or duration of seizures, even in those who develop fever post-vaccination. Many caregivers are concerned about a person with DS receiving a SARS-CoV-2 vaccine, with some reporting that they would decline a SARS-CoV-2 vaccine when offered. It is crucial that healthcare professionals are proactive in providing accurate information regarding the risks and benefi...
Source: Epilepsy and Behaviour - September 18, 2021 Category: Neurology Authors: Lisa M Clayton Simona Balestrini J Helen Cross Galia Wilson Claire Eldred Helen Evans Matthias J Koepp Sanjay M Sisodiya Source Type: research

Long-term response and response patterns to antiepileptic drugs in patients with newly diagnosed epilepsy
This study investigated the long-term response and response patterns to antiepileptic drugs (AEDs) in patients with newly diagnosed epilepsy.METHODS: Patients who had been newly diagnosed with epilepsy and had at least 3-year follow-up records were enrolled. Their long-term response and response patterns to AEDs were retrospectively analyzed. Patients were divided into two groups, a controlled group and an uncontrolled group, according to whether 3-year seizure freedom (3YSF) was achieved. Multiple logistic regression analyses were used to identify risk factors associated with a poor drug response.RESULTS: Of the 472 patie...
Source: Epilepsy and Behaviour - September 18, 2021 Category: Neurology Authors: Yudan Li Li Xia Yuxuan Wang Rong Li Jingyi Li Songqing Pan Source Type: research

Disturbance of functional and effective connectivity of the salience network involved in attention deficits in right temporal lobe epilepsy
Epilepsy Behav. 2021 Sep 15;124:108308. doi: 10.1016/j.yebeh.2021.108308. Online ahead of print.ABSTRACTThe salience network (SN) acts as a switch that generates transient control signals to regulate the executive control network (ECN) and the default mode network (DMN) and has been implicated in cognitive processes. Temporal lobe epilepsy (TLE) is usually accompanied by different types of cognitive deficits, but whether it is associated with dysfunctional connectivity of the SN remains unknown. To address this, thirty-six patients with right TLE (rTLE) and thirty-six healthy controls (HCs) were recruited for the present s...
Source: Epilepsy and Behaviour - September 18, 2021 Category: Neurology Authors: Xia Zhou Zhao Zhang Lu Yu Binglin Fan Minli Wang Binjian Jiang Yuying Su Peihu Li Jinou Zheng Source Type: research

Drugs for patients with epilepsy and excessive daytime sleepiness
Epilepsy Behav. 2021 Sep 14;124:108311. doi: 10.1016/j.yebeh.2021.108311. Online ahead of print.ABSTRACTExcessive daytime sleepiness (EDS) and attentional deficits are often observed in people with epilepsy. They may be the consequence of seizures and subclinical discharges as well as of comorbid conditions as obstructive sleep apnea/hypopnea syndrome (OSAS), attention deficit hyperactivity disorder (ADHD), or other less frequent disorders. Excessive daytime sleepiness may also be caused or worsened by antiseizure medications (ASMs). Several meta-analyses suggested that lamotrigine, lacosamide, and perhaps eslicarbazepine ...
Source: Epilepsy and Behaviour - September 17, 2021 Category: Neurology Authors: Gaetano Zaccara Emanuele Bartolini Luciana Tramacere Simona Lattanzi Source Type: research

Clinical factors associated with work disability in epilepsy: A cross-sectional study at a tertiary referral hospital
CONCLUSION: Less than 50% of patients with epilepsy in our setting are working. Factors associated with unemployment and work disability are a higher frequency of seizures, low-skilled work, depressive symptoms, and poor quality of life.PMID:34530247 | DOI:10.1016/j.yebeh.2021.108310 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - September 16, 2021 Category: Neurology Authors: Gea Mireia Grau-L ópez Lara Jim énez Marta Hern ández-Stahl Marina Fumanal Alejandra Ciurans Jordi Becerra Juan Luis Grau-L ópez Laia Source Type: research

EEG-based P300 in mesial temporal lobe epilepsy and its correlation with cognitive functions: A case-control study
This study aimed to investigate the characteristics of auditory and visual P300 in patients with TLE having unilateral HS using electroencephalography (EEG) and to study its correlation with cognition.METHODS: This is a cross-sectional case-control study, where P300 characteristics in thirty patients with unilateral hippocampal sclerosis with refractory epilepsy were compared with fifteen age-, gender-, and years of education-matched healthy controls (M: F-10:5, mean age-28 ± 4.76 years). Among patients, 15 belonged to the right HS group (M: F-9:6, age at onset-12.92 ± 10.22 years, duration of epilepsy-16.67 ...
Source: Epilepsy and Behaviour - September 14, 2021 Category: Neurology Authors: M A Mukheem Mudabbir R C Mundlamuri K R Aravind Mariyappa Narayanan Suvarna Alladi N Shivashankar Raghavendra Kenchaiah Ajay Asranna L G Viswanathan G K Bhargava Jayabal Velmurugan K Thennarasu Jamuna Rajan Karthik Kulanthaivelu Rose Dawn Bharath Jitender Source Type: research

Pharmacokinetic variability of eslicarbazepine in real clinical practice
This study involved a retrospective analysis of patients diagnosed with epilepsy treated with ESL for whom plasma levels of licarbazepine were available, measured by spectrophotometry.RESULTS: Sixty-four patients were included. One patient had licarbazepine levels of 0 (admitted not taking the drug) was not analyzed. Mean licarbazepine levels of 7.66 µg/mL (400 mg/day dose), 16.56 µg/mL (800-mg dose), and 20.80 µg/mL (1200 mg) were significantly different. There was a significant correlation between daily dose and serum levels (p
Source: Epilepsy and Behaviour - September 14, 2021 Category: Neurology Authors: Maria de Toledo Laura Valladares-Salado Jose Cebrian-Escudero Carolina Diaz-Perez Elisa de la Fuente Raquel Ferreiros Elena Sanz-Sanz Lorena Vega-Piris Alfonso Lagares Maria C Ovejero-Benito Monica Sobrado Source Type: research

EEG-based P300 in mesial temporal lobe epilepsy and its correlation with cognitive functions: A case-control study
This study aimed to investigate the characteristics of auditory and visual P300 in patients with TLE having unilateral HS using electroencephalography (EEG) and to study its correlation with cognition.METHODS: This is a cross-sectional case-control study, where P300 characteristics in thirty patients with unilateral hippocampal sclerosis with refractory epilepsy were compared with fifteen age-, gender-, and years of education-matched healthy controls (M: F-10:5, mean age-28 ± 4.76 years). Among patients, 15 belonged to the right HS group (M: F-9:6, age at onset-12.92 ± 10.22 years, duration of epilepsy-16.67 ...
Source: Epilepsy and Behaviour - September 14, 2021 Category: Neurology Authors: M A Mukheem Mudabbir R C Mundlamuri K R Aravind Mariyappa Narayanan Suvarna Alladi N Shivashankar Raghavendra Kenchaiah Ajay Asranna L G Viswanathan G K Bhargava Jayabal Velmurugan K Thennarasu Jamuna Rajan Karthik Kulanthaivelu Rose Dawn Bharath Jitender Source Type: research

Pharmacokinetic variability of eslicarbazepine in real clinical practice
This study involved a retrospective analysis of patients diagnosed with epilepsy treated with ESL for whom plasma levels of licarbazepine were available, measured by spectrophotometry.RESULTS: Sixty-four patients were included. One patient had licarbazepine levels of 0 (admitted not taking the drug) was not analyzed. Mean licarbazepine levels of 7.66 µg/mL (400 mg/day dose), 16.56 µg/mL (800-mg dose), and 20.80 µg/mL (1200 mg) were significantly different. There was a significant correlation between daily dose and serum levels (p
Source: Epilepsy and Behaviour - September 14, 2021 Category: Neurology Authors: Maria de Toledo Laura Valladares-Salado Jose Cebrian-Escudero Carolina Diaz-Perez Elisa de la Fuente Raquel Ferreiros Elena Sanz-Sanz Lorena Vega-Piris Alfonso Lagares Maria C Ovejero-Benito Monica Sobrado Source Type: research

EEG-based P300 in mesial temporal lobe epilepsy and its correlation with cognitive functions: A case-control study
This study aimed to investigate the characteristics of auditory and visual P300 in patients with TLE having unilateral HS using electroencephalography (EEG) and to study its correlation with cognition.METHODS: This is a cross-sectional case-control study, where P300 characteristics in thirty patients with unilateral hippocampal sclerosis with refractory epilepsy were compared with fifteen age-, gender-, and years of education-matched healthy controls (M: F-10:5, mean age-28 ± 4.76 years). Among patients, 15 belonged to the right HS group (M: F-9:6, age at onset-12.92 ± 10.22 years, duration of epilepsy-16.67 ...
Source: Epilepsy and Behaviour - September 14, 2021 Category: Neurology Authors: M A Mukheem Mudabbir R C Mundlamuri K R Aravind Mariyappa Narayanan Suvarna Alladi N Shivashankar Raghavendra Kenchaiah Ajay Asranna L G Viswanathan G K Bhargava Jayabal Velmurugan K Thennarasu Jamuna Rajan Karthik Kulanthaivelu Rose Dawn Bharath Jitender Source Type: research

Pharmacokinetic variability of eslicarbazepine in real clinical practice
This study involved a retrospective analysis of patients diagnosed with epilepsy treated with ESL for whom plasma levels of licarbazepine were available, measured by spectrophotometry.RESULTS: Sixty-four patients were included. One patient had licarbazepine levels of 0 (admitted not taking the drug) was not analyzed. Mean licarbazepine levels of 7.66 µg/mL (400 mg/day dose), 16.56 µg/mL (800-mg dose), and 20.80 µg/mL (1200 mg) were significantly different. There was a significant correlation between daily dose and serum levels (p
Source: Epilepsy and Behaviour - September 14, 2021 Category: Neurology Authors: Maria de Toledo Laura Valladares-Salado Jose Cebrian-Escudero Carolina Diaz-Perez Elisa de la Fuente Raquel Ferreiros Elena Sanz-Sanz Lorena Vega-Piris Alfonso Lagares Maria C Ovejero-Benito Monica Sobrado Source Type: research

EEG-based P300 in mesial temporal lobe epilepsy and its correlation with cognitive functions: A case-control study
This study aimed to investigate the characteristics of auditory and visual P300 in patients with TLE having unilateral HS using electroencephalography (EEG) and to study its correlation with cognition.METHODS: This is a cross-sectional case-control study, where P300 characteristics in thirty patients with unilateral hippocampal sclerosis with refractory epilepsy were compared with fifteen age-, gender-, and years of education-matched healthy controls (M: F-10:5, mean age-28 ± 4.76 years). Among patients, 15 belonged to the right HS group (M: F-9:6, age at onset-12.92 ± 10.22 years, duration of epilepsy-16.67 ...
Source: Epilepsy and Behaviour - September 14, 2021 Category: Neurology Authors: M A Mukheem Mudabbir R C Mundlamuri K R Aravind Mariyappa Narayanan Suvarna Alladi N Shivashankar Raghavendra Kenchaiah Ajay Asranna L G Viswanathan G K Bhargava Jayabal Velmurugan K Thennarasu Jamuna Rajan Karthik Kulanthaivelu Rose Dawn Bharath Jitender Source Type: research

Pharmacokinetic variability of eslicarbazepine in real clinical practice
This study involved a retrospective analysis of patients diagnosed with epilepsy treated with ESL for whom plasma levels of licarbazepine were available, measured by spectrophotometry.RESULTS: Sixty-four patients were included. One patient had licarbazepine levels of 0 (admitted not taking the drug) was not analyzed. Mean licarbazepine levels of 7.66 µg/mL (400 mg/day dose), 16.56 µg/mL (800-mg dose), and 20.80 µg/mL (1200 mg) were significantly different. There was a significant correlation between daily dose and serum levels (p
Source: Epilepsy and Behaviour - September 14, 2021 Category: Neurology Authors: Maria de Toledo Laura Valladares-Salado Jose Cebrian-Escudero Carolina Diaz-Perez Elisa de la Fuente Raquel Ferreiros Elena Sanz-Sanz Lorena Vega-Piris Alfonso Lagares Maria C Ovejero-Benito Monica Sobrado Source Type: research

Postictal headache is a common complaint that is largely ignored by the scientific community
Epilepsy Behav. 2021 Sep 9:108300. doi: 10.1016/j.yebeh.2021.108300. Online ahead of print.NO ABSTRACTPMID:34511395 | DOI:10.1016/j.yebeh.2021.108300 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - September 13, 2021 Category: Neurology Authors: Ali A Asadi-Pooya Source Type: research

Postictal headache is a common complaint that is largely ignored by the scientific community
Epilepsy Behav. 2021 Sep 9:108300. doi: 10.1016/j.yebeh.2021.108300. Online ahead of print.NO ABSTRACTPMID:34511395 | DOI:10.1016/j.yebeh.2021.108300 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - September 13, 2021 Category: Neurology Authors: Ali A Asadi-Pooya Source Type: research

Response to: "Healthy brain-muscle interface in epilepsy and COVID-19: Increased muscle effort is the alternative"
Epilepsy Behav. 2021 Aug 28:108301. doi: 10.1016/j.yebeh.2021.108301. Online ahead of print.NO ABSTRACTPMID:34509396 | DOI:10.1016/j.yebeh.2021.108301 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - September 12, 2021 Category: Neurology Authors: Naoto Kuroda Ayataka Fujimoto Source Type: research

A vitamin D enriched diet attenuates sex-specific behavioral deficits, increases the lifespan, but does not rescue bone abnormalities in a mouse model of cortical dysplasia
Epilepsy Behav. 2021 Sep 9;124:108297. doi: 10.1016/j.yebeh.2021.108297. Online ahead of print.ABSTRACTIndividuals who experience recurrent spontaneous seizures often show behavioral and physiological comorbidities. Those with epilepsy are at a high risk of bone fractures (independent of seizure-related falls) and show a higher rate of a diagnosis of Autism Spectrum Disorder. The neural subset-specific (NS) Pten knockout (KO) mouse has an epilepsy phenotype, has been characterized to show autistic-like deficits, and has an osteoporosis phenotype. The current study examined the effect of a vitamin D enriched diet (20,000 IU...
Source: Epilepsy and Behaviour - September 12, 2021 Category: Neurology Authors: Paige D Womble Samantha L Hodges Suzanne O Nolan Matthew S Binder Andrew J Holley Rebecca Herrera Savannah Senger Eliesse Kwok David A Narviaz Amanda Faust Christian J Hernandez-Zegada Ronald Y Kwon Joaquin N Lugo Source Type: research

Safety and efficacy of rufinamide in children and adults with Lennox-Gastaut syndrome: A post hoc analysis from Study 022
Epilepsy Behav. 2021 Sep 9;124:108275. doi: 10.1016/j.yebeh.2021.108275. Online ahead of print.ABSTRACTBACKGROUND: Lennox-Gastaut syndrome (LGS) is a developmental and epileptic encephalopathy with the first symptoms usually appearing during early childhood. Due to the highly variable underlying etiologies, LGS cannot be considered as one disease but as an electro-clinical entity, often challenging to diagnose early and treat accordingly. The anti-seizure medication, rufinamide, is indicated for the adjunctive treatment of patients with LGS aged ≥1 year. This post hoc analysis assessed the safety and efficacy of adjunct...
Source: Epilepsy and Behaviour - September 12, 2021 Category: Neurology Authors: Alexis Arzimanoglou Milka Pringsheim Gerhard Josef Kluger Pierre Genton Carlos Perdomo Manoj Malhotra Source Type: research

Cognitive outcomes following frontal lobe resection for treatment of epilepsy in children and adolescents
Epilepsy Behav. 2021 Sep 9;124:108265. doi: 10.1016/j.yebeh.2021.108265. Online ahead of print.ABSTRACTOBJECTIVE: To use reliable change indices (RCIs) developed specifically for pediatric patients with epilepsy to examine cognitive outcomes after frontal lobe resection for pharmacoresistant epilepsy.METHODS: Forty-one pediatric patients (25 male, Mage = 10 years) completed comprehensive neuropsychological evaluations before and an average of 6.5 months after frontal lobe resections for treatment of epilepsy. Evaluations included tests of intelligence, attention/working memory, processing speed, language, visuospatial skil...
Source: Epilepsy and Behaviour - September 12, 2021 Category: Neurology Authors: Lisa Ferguson Margaret Miller Alexander Whiting Jennifer Haut Patricia Klaas William Bingaman Deepak Lachhwani Tara T Lineweaver Darlene Floden Robyn M Busch Source Type: research

Practical guidance for the management of adults receiving adjunctive cenobamate for the treatment of focal epilepsy-expert opinion
Epilepsy Behav. 2021 Sep 8;123:108270. doi: 10.1016/j.yebeh.2021.108270. Online ahead of print.ABSTRACTClinical trial results have demonstrated that adjunctive cenobamate (CNB) substantially decreases seizure frequency in adults with uncontrolled focal onset seizures with an acceptable and well-identified safety profile. This manuscript summarizes an expert panel's recommendations regarding optimized CNB treatment of epilepsies with focal onset seizures. Cenobamate, when slowly titrated to the target maintenance dose, represents an effective new antiseizure medication (ASM) with a comparatively high rate of seizure freedom...
Source: Epilepsy and Behaviour - September 11, 2021 Category: Neurology Authors: Bernhard J Steinhoff William E Rosenfeld Jos é M Serratosa Christian Brandt Pavel Klein Manuel Toledo Gregory L Krauss Source Type: research

Difficulties obtaining private insurance reported by persons with epilepsy in Korea
This study determined the proportion of persons with epilepsy (PWE) that possessed insurance policies and the difficulties they experienced in trying to obtain insurance in South Korea.METHODS: Persons with epilepsy and healthy control subjects were asked to complete a questionnaire in which they were asked if they had experienced problems obtaining four types of insurance, including life, medical indemnity, critical illness, and motor insurance. Insurance policies obtained before diagnosis of epilepsy were excluded in the analysis.RESULTS: This study included 106 adults with epilepsy and 87 healthy control subjects. The p...
Source: Epilepsy and Behaviour - September 11, 2021 Category: Neurology Authors: Sang-Ahm Lee Kayeong Im Ha-Rin Yang Source Type: research

Comparison of healthcare resource utilization in pediatric patients with refractory epilepsy: Vagus nerve stimulation and medical treatment cohorts
CONCLUSIONS: Compared to those treated with AEDs only, pediatric patients with refractory epilepsy treated with AEDs plus VNS have fewer inpatient visits and more outpatient visits within a 2-year follow-up. Given the lower acuity of care in outpatient versus inpatient settings, this study can inform treatment choices for children with refractory epilepsy.PMID:34509035 | DOI:10.1016/j.yebeh.2021.108281 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - September 11, 2021 Category: Neurology Authors: Lu Zhang Joyce Y Wu Sandi K Lam Source Type: research

Impact of intellectual and developmental disability on quality-of-life priorities in adults with epilepsy
This study sought to (1) conduct a survey of HR-QOL priorities identified by adults with IDD-E and caregivers, and (2) perform an exploratory cross-sectional comparison to adults with epilepsy who do not have IDD.METHODS: This cross-sectional study recruited 65 adults with IDD-E and 134 adults with epilepsy without IDD and caregivers. Using a three-step development process, 256 items from existing quality-of-life scales recommended by the American Academy of Neurology (AAN) were rated by patients/caregivers for their importance as HR-QOL priorities. HR-QOL items identified as critical to the majority of the sample of adult...
Source: Epilepsy and Behaviour - September 11, 2021 Category: Neurology Authors: Sharon Chiang Robert Moss Mary Anne Meskis Vanessa Vogel-Farley Joseph E Sullivan Anup D Patel Vikram R Rao Source Type: research

Alcohol use among patients with epilepsy in western China. A hospital-based study
CONCLUSION: This study revealed that the rate of alcohol use among patients with epilepsy was high. Male patients with a history of alcohol use were more prone to alcohol use after a diagnosis of epilepsy. Heavy alcohol use and frequent alcohol use were independently associated with worsening of seizure control after alcohol use in patients with epilepsy. Patient education on the destructive effects of alcohol use is needed for patients with epilepsy.PMID:34509040 | DOI:10.1016/j.yebeh.2021.108302 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - September 11, 2021 Category: Neurology Authors: Yi Guo Peishan Du Lixia Guo Xu Lin Baoming He Liang Yu Source Type: research

Machine learning models for decision support in epilepsy management: A critical review
CONCLUSION: The utility of ML models for clinical decision support in epilepsy management remains to be determined. Future research should be directed toward conducting larger studies with external validation, standardization of reporting, and prospective evaluation of the ML model on patient outcomes.PMID:34507093 | DOI:10.1016/j.yebeh.2021.108273 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - September 10, 2021 Category: Neurology Authors: Eliot D Smolyansky Haris Hakeem Zongyuan Ge Zhibin Chen Patrick Kwan Source Type: research

Recovery of cortical atrophy in patients with temporal lobe epilepsy after successful anterior temporal lobectomy
This study suggests that the cortical atrophy caused by TLE could recover after successful ATL. The recovery ability is greater in younger subjects and is positively related to cognitive recovery. These findings could serve as new clues that patients with TLE can benefit from timely and successful ATL.PMID:34500432 | DOI:10.1016/j.yebeh.2021.108272 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - September 9, 2021 Category: Neurology Authors: Yongxiang Zhao Chao Zhang Hongyu Yang Chang Liu Tao Yu Jie Lu Nan Chen Kuncheng Li Source Type: research

Knowledge, attitudes, and practices of caregivers of children with epilepsy in Sudan
Epilepsy Behav. 2021 Sep 6;123:108283. doi: 10.1016/j.yebeh.2021.108283. Online ahead of print.ABSTRACTOBJECTIVE: To explore the knowledge, attitudes, and practices of caregivers of children with epilepsy.METHODS: This cross-sectional study included 107 consecutive caregivers of children diagnosed with epilepsy, attending the neurology outpatient clinic in a Pediatric tertiary university hospital, in Khartoum, Sudan for regular check-up. Data were obtained by an interviewer through a structured questionnaire, while clinical parameters of children with epilepsy were taken from medical records.RESULTS: Most respondents knew ...
Source: Epilepsy and Behaviour - September 9, 2021 Category: Neurology Authors: Rahba O El-Amin Sarah M El-Sadig Inaam N Mohamed Source Type: research

Validation of the Generalized Anxiety Disorder-7 (GAD-7) in Russian people with epilepsy
CONCLUSION: Russian version of the GAD-7 could be used as a screening tool for any anxiety disorders in PWE with the optimal cutoff score> 8 points.PMID:34500434 | DOI:10.1016/j.yebeh.2021.108269 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - September 9, 2021 Category: Neurology Authors: Mikhail Zinchuk Georgii Kustov Evgenii Pashnin Anna Gersamia Flora Rider Alexander Yakovlev Nadezhda Voinova Sofya Popova Alla Avedisova Alla Guekht Source Type: research

Knowledge, attitude, and barriers for epilepsy surgery: A survey among resident doctors in a tertiary care center in India
This study aimed at analyzing knowledge, attitude, and barriers for epilepsy surgery among medical residents.METHODS: A survey consisting of 16 statements in a Likert-like scale and one open-ended question was conducted among residents joining different postgraduate courses after MBBS (GR) and super-specialty courses after MD (PG) within 2 months of joining the institute. PGs with a postgraduate degree in internal medicine, pediatrics, or psychiatry were included. Demographic data were analyzed using descriptive statistics. Difference in response to the survey statements was analyzed using independent t test.RESULTS: 115 p...
Source: Epilepsy and Behaviour - September 9, 2021 Category: Neurology Authors: Kamalesh Chakravarty Sarath Aleti Parampreet S Kharbanda Vivek Lal Jitupam Baishya Source Type: research

Treatment of postictal headache
Epilepsy Behav. 2021 Sep 4:108285. doi: 10.1016/j.yebeh.2021.108285. Online ahead of print.NO ABSTRACTPMID:34493459 | DOI:10.1016/j.yebeh.2021.108285 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - September 8, 2021 Category: Neurology Authors: Carlo Cianchetti Source Type: research

Treatment of postictal headache
Epilepsy Behav. 2021 Sep 4:108285. doi: 10.1016/j.yebeh.2021.108285. Online ahead of print.NO ABSTRACTPMID:34493459 | DOI:10.1016/j.yebeh.2021.108285 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - September 8, 2021 Category: Neurology Authors: Carlo Cianchetti Source Type: research

Not only Struwwelpeter: Heinrich Hoffmann (1809-1894) and his thoughtful observations on epilepsy
Epilepsy Behav. 2021 Sep 4;123:108268. doi: 10.1016/j.yebeh.2021.108268. Online ahead of print.ABSTRACTHeinrich Hoffmann (1809-1894) is the author of Der Struwwelpeter (Shaggy Peter, 1845), a famous collection of moralistic tales for children. He was a psychiatrist who founded the mental asylum in Frankfurt am Mein. In 1859, Hoffmann published a book on "Observations on mental disorders and epilepsy", following the classification system proposed by Wilhelm Griesinger (1817-1868). Herein, Hoffmann explores, among others, the influence of lunar phases, seasonality, and circadian rhythm on seizure frequency, topics ...
Source: Epilepsy and Behaviour - September 7, 2021 Category: Neurology Authors: Francesco Brigo Source Type: research

Outcomes in the treatment of psychogenic nonepileptic seizures (PNES) with CBTip: Response in seizure frequency, depression, anxiety, and quality of life
CONCLUSIONS: Our analysis showed that patients treated with CBTip with a minimum of 7 sessions in 3 months did not have significant improvement. However, attending at least 7 sessions of CBTip in longer than 3 months was effective for seizure control, depression, and anxiety. The observational and exploratory nature of our study, however, limits the generalizability of our findings outside of the single tertiary clinical care setting.PMID:34492542 | DOI:10.1016/j.yebeh.2021.108277 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - September 7, 2021 Category: Neurology Authors: Becky Bikat S Tilahun Nicolas R Thompson Lauren R Sankary Firdaws Laryea Charles M Trunick Lara E Jehi Source Type: research

Anesthesia considerations for patients with epilepsy: Findings of a qualitative study in the Palestinian practice
CONCLUSION: Findings of this study highlighted the need to develop specific anesthesia protocols for patients with epilepsy. Anesthesiologists and planners of perioperative care should improve collection of patient information and assessment methods, ensure control over seizures, reduce triggers of seizures, and improve patient monitoring approaches. Findings of this study might be used to inform anesthesiologists and decision makers in professional groups, patient advocacy groups, and healthcare authorities to benchmark and improve anesthesia care and services offered to patients with epilepsy. More studies are still need...
Source: Epilepsy and Behaviour - September 7, 2021 Category: Neurology Authors: Mohammad Jaber Ramzi Shawahna Majd Abu-Issa Faris Radwan Mohammad Dweik Source Type: research

Healthy brain-muscle interface in epilepsy and COVID-19: Increased muscle effort is the alternative
Epilepsy Behav. 2021 Aug 16:108267. doi: 10.1016/j.yebeh.2021.108267. Online ahead of print.NO ABSTRACTPMID:34481755 | DOI:10.1016/j.yebeh.2021.108267 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - September 5, 2021 Category: Neurology Authors: Rodrigo Luiz Vancini Mar ília Santos Andrade Beat Knechtle Pantelis Theodoros Nikolaidis Claudio Andre Barbosa de Lira Source Type: research

Recommendations for development of acute seizure action plans (ASAPs) from an expert panel
Epilepsy Behav. 2021 Sep 2;123:108264. doi: 10.1016/j.yebeh.2021.108264. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: Disease-related treatment action plans for acute exacerbations providing information that may be helpful for self-management for patients and caregivers are commonly used for chronic conditions such as asthma and diabetes. However, among patients with epilepsy, a review of the literature suggested that the majority did not have an action plan in place for acute seizure treatment.RECENT FINDINGS: Currently, there is a lack of unified guidance on seizure action plans (SAPs) in the literature. In the autho...
Source: Epilepsy and Behaviour - September 5, 2021 Category: Neurology Authors: Patricia Penovich Tracy Glauser Danielle Becker Anup D Patel Joseph Sirven Lucretia Long John Stern Tracy Dixon-Salazar Enrique Carrazana Adrian L Rabinowicz Source Type: research

An observational report of swallowing outcomes following corpus callosotomy
Epilepsy Behav. 2021 Sep 2;123:108271. doi: 10.1016/j.yebeh.2021.108271. Online ahead of print.ABSTRACTAIM: Determine swallowing outcomes following corpus callosotomy (CC) surgery.METHODS: Retrospective chart review of patients undergoing CC between July 2016 and November 2018 at a large, urban children's hospital.RESULTS: Of the 18 patients without prior history of dysphagia who underwent CC, 15 received speech pathology consults for bedside swallowing evaluation (BSE). Four patients were referred for a videofluroscopic swallow study (VFSS), and 3 showed no signs of difficulty and were advanced to regular diets with thin ...
Source: Epilepsy and Behaviour - September 5, 2021 Category: Neurology Authors: Noel Pristas Nathan Rosenberg Jonathan Pindrik Adam P Ostendorf Jennifer P Lundine Source Type: research

Impact of the COVID-19 pandemic on people with epilepsy: Findings from the Brazilian arm of the COV-E study
CONCLUSION: Our findings suggest that Brazilians with epilepsy have been adversely affected by COVID-19 by factors beyond infection or mortality. Mental health issues and the importance of optimal communication are critical during these difficult times. Healthcare services need to find nuanced approaches and learn from shared international experiences to provide optimal care for people with epilepsy as the direct burden of COVID-19 improves in some countries. In contrast, others face resurgent waves of the pandemic.PMID:34481281 | DOI:10.1016/j.yebeh.2021.108261 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - September 4, 2021 Category: Neurology Authors: Maria Andraus Jennifer Thorpe Xin You Tai Samantha Ashby Asma Hallab Ding Ding Patricia Dugan Piero Perucca Daniel Costello Jacqueline A French Terence J O'Brien Chantal Depondt Danielle M Andrade Robin Sengupta Norman Delanty Nathalie Jette Charles R New Source Type: research