The role of devices in managing risk.
Abstract Over the last few years, there has been significant expansion of wearable technologies and devices into the health sector, including for conditions such as epilepsy. Although there is significant potential to benefit patients, there is a paucity of well-conducted scientific research in order to inform patients and healthcare providers of the most appropriate technology. In addition to either directly or indirectly identifying seizure activity, the ideal device should improve quality of life and reduce the risk of sudden unexpected death in epilepsy (SUDEP). Devices typically monitor a number of parameters...
Source: Epilepsy and Behaviour - August 17, 2019 Category: Neurology Authors: Rugg-Gunn F Tags: Epilepsy Behav Source Type: research

SUDEP and mortality in epilepsy: The role of routinely collected healthcare data, registries, and health inequalities.
Abstract Routinely collected data are a powerful research resource and offer the opportunity to further our understanding of epilepsy mortality and Sudden Unexpected Death in Epilepsy (SUDEP). The advantages of using routinely collected data include that it often covers whole populations, is already collected, and can be easily linked to other data sources. A significant disadvantage is the difficulty in obtaining accurate causes of death and correctly identifying cases of SUDEP. Using and linking data from epilepsy death registries can improve the quality of mortality data for research. Epilepsy prevalence, incid...
Source: Epilepsy and Behaviour - August 17, 2019 Category: Neurology Authors: Pickrell WO, Kerr MP Tags: Epilepsy Behav Source Type: research

BLAST paradigm: A new test to assess brief attentional fluctuations in children with epilepsy, ADHD, and normally developing children.
CONCLUSIONS: This study demonstrates that attentional stability is impaired in children with epilepsy and/or ADHD. Bron-Lyon Attention Stability Test seems to be a sensitive test to detect attentional stability deficit in children with epilepsy and with attentional complaints who did not meet all criteria of ADHD. We propose that BLAST could be a useful clinical neuropsychological tool to assess attentional disorders in children. PMID: 31430660 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - August 17, 2019 Category: Neurology Authors: Thieux M, Jung J, Bouet R, Gerard D, Bauer PR, Bertrand O, Perrone-Bertolotti M, Arzimanoglou A, Kahane P, Lachaux JP, De Bellescize J, Herbillon V Tags: Epilepsy Behav Source Type: research

The right insular cortex: A critical region for modulating the sympathetic activity?
PMID: 31427264 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - August 16, 2019 Category: Neurology Authors: Nagai M, Dote K, Kato M Tags: Epilepsy Behav Source Type: research

Modeling poststroke epilepsy and preclinical development of drugs for poststroke epilepsy.
This article is part of the Special Issue "Seizures & Stroke". PMID: 31427267 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - August 16, 2019 Category: Neurology Authors: Leo A, De Caro C, Nesci V, Tallarico M, De Sarro G, Russo E, Citraro R Tags: Epilepsy Behav Source Type: research

Gamma electroencephalographic coherence and theory of mind in healthy subjects.
CONCLUSIONS: In healthy adults, ToM processes are associated with immediate specific changes of brain connectivity, as expressed by high cortical coherence within the right frontal and parietal areas. These previously unexplored aspects indicate an online involvement of the right hemisphere networks in normal ToM. In patients with epilepsy, the study of EEG coherence during specific tasks may help determine the neural dysfunctions associated with impaired ToM. This article is part of the Special Issue "Epilepsy and social cognition across the lifespan". PMID: 31427268 [PubMed - as supplied by publisher] (Sou...
Source: Epilepsy and Behaviour - August 16, 2019 Category: Neurology Authors: Panzica F, Schiaffi E, Visani E, Franceschetti S, Giovagnoli AR Tags: Epilepsy Behav Source Type: research

Sleep disorders and behavioral disorders in Jamaican children with epilepsy: A case-control study.
Abstract Children with epilepsy (CWE) are more likely to have sleep and behavioral disorders. With differences in reports, the aim was to evaluate sleep and behavior in Jamaican CWE and determine any association with epilepsy-related variables. Children with epilepsy were identified along with age and gender-matched controls from the University Hospital of the West Indies and the Bustamante Hospital for Children. Written informed consent was obtained followed by the completion of questionnaires assessing sleep, behavior, and background of both cases and controls. Parents of 61 children (26 cases and 35 controls) p...
Source: Epilepsy and Behaviour - August 16, 2019 Category: Neurology Authors: Graham L, Gossell-Williams M, Tapper J, Melbourne-Chambers R Tags: Epilepsy Behav Source Type: research

Electrical stimulation mapping of language with stereo-EEG.
Abstract OBJECTIVE: We prospectively validated stereo-electroencephalography (EEG) electrical stimulation mapping (ESM) of language against a reference standard of meta-analytic functional magnetic resonance imaging (fMRI) framework (Neurosynth). METHODS: Language ESM was performed using 50 Hz, biphasic, bipolar, stimulation at 1-8 mA, with a picture naming task. Electrode contacts (ECs) were scored as ESM+ if ESM interfered with speech/language function. For each patient, presurgical MRI was transformed to a standard space and coregistered with computed tomographic (CT) scan to obtain EC locations. After...
Source: Epilepsy and Behaviour - August 15, 2019 Category: Neurology Authors: Arya R, Ervin B, Dudley J, Buroker J, Rozhkov L, Scholle C, Horn PS, Vannest J, Byars AW, Leach JL, Mangano FT, Greiner HM, Holland KD, Glauser TA Tags: Epilepsy Behav Source Type: research

Development of a patient-reported outcome measure for psychotherapeutic interventions in people with seizures: A mixed methods study.
CONCLUSION: Based on these results, the EASE is valid in terms of content, internally consistent, clear, and acceptable to patients with seizures. The measure has now been developed to the stage at which the validity and reliability as well as the psychometric properties and factorial structure of the new instrument can be assessed in larger patient groups in a prospective clinical study. PMID: 31421518 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - August 14, 2019 Category: Neurology Authors: Michaelis R, Meyer S, Reuber M, Schöne C Tags: Epilepsy Behav Source Type: research

Prognostic factors in epileptic encephalopathies at onset in the first 2  years of life: The experience of a tertiary healthcare center in Italy.
Prognostic factors in epileptic encephalopathies at onset in the first 2 years of life: The experience of a tertiary healthcare center in Italy. Epilepsy Behav. 2019 Aug 14;99:106465 Authors: Pellino G, Chiavarino F, Fiumana E, Boni A, Russo A, Faggioli R Abstract INTRODUCTION: The aim of this retrospective cohort study was to identify some prognostic factors in anamnestic/clinical/instrumental data at the onset of epileptic encephalopathy (EE), for multiple outcome measures. METHODS: We recruited patients diagnosed as affected by EE at Sant'Anna University Hospital, with onset in the first 24...
Source: Epilepsy and Behaviour - August 14, 2019 Category: Neurology Authors: Pellino G, Chiavarino F, Fiumana E, Boni A, Russo A, Faggioli R Tags: Epilepsy Behav Source Type: research

Patients' knowledge on epilepsy and SUDEP improves after a semi-structured health interview.
Toledano R, García-Morales I Abstract BACKGROUND: Patients' education is the most relevant contributor to patient self-management of epilepsy. We aimed to assess the acquisition of knowledge after a semi-structured interview. METHODS: We performed a quasi-experimental prospective study with a cohort of patients with epilepsy admitted for prolonged video electroencephalogram (VEEG). We measured patients' baseline knowledge with a 10-item true-false test (test A). Then, a qualified nurse carried out a semi-structured interview. We measured acquired knowledge with another 10-item true-false exam (test B),...
Source: Epilepsy and Behaviour - August 14, 2019 Category: Neurology Authors: Gutiérrez-Viedma Á, Sanz-Graciani I, Romeral-Jiménez M, Parejo-Carbonell B, Serrano-García I, Cuadrado ML, Aledo-Serrano Á, Gil-Nagel A, Toledano R, García-Morales I Tags: Epilepsy Behav Source Type: research

Electrographic seizure burden and outcomes following pediatric status epilepticus.
This article is part of the Special Issue "Proceedings of the 7th London-Innsbruck Colloquium on Status Epilepticus and Acute Seizures". PMID: 31420288 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - August 13, 2019 Category: Neurology Authors: Lalgudi Ganesan S, Hahn CD Tags: Epilepsy Behav Source Type: research

Physical fitness levels and moderators in people with epilepsy: A systematic review and meta-analysis.
Abstract Cardiorespiratory fitness (CRF) is a modifiable risk factor for mental and physical chronic conditions and premature mortality. Cardiorespiratory fitness levels and moderators among people living with epilepsy are unknown. The aim of the current meta-analysis was to (1) determine mean CRF in people living with epilepsy and compare levels with age- and gender-matched healthy controls (HCs), and (2) explore moderators of CRF. Major electronic databases were searched systematically for articles reporting CRF expressed as maximum or peak oxygen uptake (ml/min/kg). A random effects meta-analysis calculating th...
Source: Epilepsy and Behaviour - August 13, 2019 Category: Neurology Authors: Vancampfort D, Ward PB, Stubbs B Tags: Epilepsy Behav Source Type: research

New anticonvulsant candidates prevent P-glycoprotein (P-gp) overexpression in a pharmacoresistant seizure model in mice.
Abstract Despite the approval of a considerable number of last generation antiepileptic drugs (AEDs) (only in the last decade, six drugs have gained Food and Drug Administration approval), the global figures of seizure control have seemingly not improved, and available AED can still be regarded as symptomatic treatments. Fresh thinking in AEDs drug discovery, including the development of drugs with novel mechanisms of action, is required to achieve truly innovative antiepileptic medications. The transporter hypothesis proposes that inadequate penetration of AEDs across the blood-brain barrier, caused by increased ...
Source: Epilepsy and Behaviour - August 13, 2019 Category: Neurology Authors: Enrique AV, Di Ianni ME, Goicoechea S, Lazarowski A, Valle-Dorado MG, Costa JJL, Rocha L, Girardi E, Talevi A Tags: Epilepsy Behav Source Type: research

The anesthetic drug treatment of refractory and super-refractory status epilepticus around the world: Results from a global audit.
This article is part of the Special Issue "Proceedings of the 7th London-Innsbruck Colloquium on Status Epilepticus and Acute Seizures". PMID: 31420291 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - August 13, 2019 Category: Neurology Authors: Ferlisi M, Hocker S, Trinka E, Shorvon S, International Steering Committee of the StEp Audit Tags: Epilepsy Behav Source Type: research

Knowledge, expectations and fears of cannabis use of epilepsy patients at a tertiary epilepsy center.
CONCLUSION: Many epilepsy patients knew about medical cannabis, were interested in this treatment, and wanted more information. Expectations, however, appear to be based on the connotations of the whole substance cannabis with tetrahydrocannabidiol and its commonly known effects. Unfortunately, patients did not get their information from physicians, but mostly by other sources. In order to avoid prejudices and potentially harmful self-medication, physicians and healthcare providers are called to become familiar with the substance and to inform patients adequately. PMID: 31419634 [PubMed - as supplied by publisher] (So...
Source: Epilepsy and Behaviour - August 13, 2019 Category: Neurology Authors: von Wrede R, Moskau-Hartmann S, Amarell N, Elger CE, Helmstaedter C Tags: Epilepsy Behav Source Type: research

Anxiety disorders in predominantly African American and Caribbean American adults with intractable epilepsy: The role of perceived epilepsy stigma.
CONCLUSIONS: Anxiety disorders were prevalent in these predominantly African American and Caribbean American PWE. Epilepsy-specific risk factors included convulsive seizures, seizure worry, and perceived epilepsy stigma. Interventions aimed at treating anxiety disorders in diverse PWE may especially benefit from targeting stigma beliefs. PMID: 31419635 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - August 13, 2019 Category: Neurology Authors: Margolis SA, Gonzalez JS, Faria C, Kenney L, Grant AC, Nakhutina L Tags: Epilepsy Behav Source Type: research

A model for visual naming based on spatiotemporal dynamics of ECoG high-gamma modulation.
CONCLUSIONS: During visual naming, ECoG HGM shows a sequential but overlapping spatiotemporal course through cortical regions. We provide neurophysiologic validation for a model of visual naming incorporating both modular and distributed cortical processing. This may explain cognitive deficits seen in some patients after surgery involving HGM naming sites outside perisylvian language cortex. PMID: 31419636 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - August 13, 2019 Category: Neurology Authors: Arya R, Babajani-Feremi A, Byars AW, Vannest J, Greiner HM, Wheless JW, Mangano FT, Holland KD Tags: Epilepsy Behav Source Type: research

Early clinical and EEG findings associated with the outcome in childhood absence epilepsy.
CONCLUSIONS: The assessment of electroclinical features provided only minimal prognostic indices. The enhanced outflow of frontal oscillations suggests a circuitry dysfunction significantly greater in the nonresponder to the early treatment. Seizure relapses were rare and comparable in patients who reached seizure freedom with first or second AED, indicating that the resistance to one AED does not influence the outcome. PMID: 31419648 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - August 13, 2019 Category: Neurology Authors: Canafoglia L, Dettori MS, Duran D, Ragona F, Freri E, Casellato S, Granata T, Franceschetti S, Panzica F Tags: Epilepsy Behav Source Type: research

Memory and motor control in patients with psychogenic nonepileptic seizures.
Abstract Psychogenic nonepileptic seizures (PNES) are of the most elusive phenomena in epileptology. Patients with PNES present episodes resembling epileptic seizures in their semiology yet lacking the underlying epileptic brain activity. These episodes are assumed to be related to psychological distress from past trauma, yet the underlying mechanism of this manifestation is still unknown. Using resting-state functional magnetic resonance imaging (fMRI), we investigated functional connectivity changes within and between large-scale brain networks in 9 patients with PNES, compared with a group of 13 age- and gender...
Source: Epilepsy and Behaviour - August 13, 2019 Category: Neurology Authors: Dienstag A, Ben-Naim S, Gilad M, Ekstein D, Arzy S, Eitan R Tags: Epilepsy Behav Source Type: research

Epilepsy and seizure-related deaths: Mortality statistics do not tell the complete story.
CONCLUSIONS: Epilepsy and seizure-related deaths are underreported in the Australian Coronial system. Enhanced documentation of the causal chain of events leading to deaths would increase recognition. Using the unified SUDEP definition would expand SUDEP identification. PMID: 31408827 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - August 10, 2019 Category: Neurology Authors: Panelli RJ, O'Brien TJ Tags: Epilepsy Behav Source Type: research

New avenues in molecular genetics for the diagnosis and application of therapeutics to the epilepsies.
des I Abstract Genetic epidemiology studies have shown that most epilepsies involve some genetic cause. In addition, twin studies have helped strengthen the hypothesis that in most patients with epilepsy, a complex inheritance is involved. More recently, with the development of high-density single-nucleotide polymorphism (SNP) microarrays and next-generation sequencing (NGS) technologies, the discovery of genes related to the epilepsies has accelerated tremendously. Especially, the use of whole exome sequencing (WES) has had a considerable impact on the identification of rare genetic variants with large effect siz...
Source: Epilepsy and Behaviour - August 7, 2019 Category: Neurology Authors: Magalhães PHM, Moraes HT, Athie MCP, Secolin R, Lopes-Cendes I Tags: Epilepsy Behav Source Type: research

Reply to commentary on "Predicting seizure freedom after epilepsy surgery, a challenge in clinical practice".
Reply to commentary on "Predicting seizure freedom after epilepsy surgery, a challenge in clinical practice". Epilepsy Behav. 2019 Aug 06;:106442 Authors: Jehi L, Kattan M PMID: 31399337 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - August 6, 2019 Category: Neurology Authors: Jehi L, Kattan M Tags: Epilepsy Behav Source Type: research

Amygdala lesions reduce seizure-induced respiratory arrest in DBA/1 mice.
This article is part of the Special Issue NEWroscience 2018. PMID: 31399338 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - August 6, 2019 Category: Neurology Authors: Marincovich A, Bravo E, Dlouhy B, Richerson GB Tags: Epilepsy Behav Source Type: research

Healthcare resource utilization and costs before and after lacosamide initiation as adjunctive therapy among patients with epilepsy in the United States.
This study used a single-case design whereby patients served as their own controls. Patients were further required to have a minimum of 12 months of continuous eligibility before (preindex period) and after (postindex period) their index event. In the 12-month postindex period, the only allowed AED regimen change was the addition of LCM. Demographic and clinical characteristics were measured at index and during the preindex period, respectively. All-cause and epilepsy-specific healthcare resource utilization and costs were measured and compared in the pre- and postindex periods. Paired t- and McNemar's tests were conduct...
Source: Epilepsy and Behaviour - August 6, 2019 Category: Neurology Authors: Fishman J, Martin M, Labiner DM, Lew CR, Johnson BH Tags: Epilepsy Behav Source Type: research

The role of task-based neural activation research in understanding cognitive deficits in pediatric epilepsy.
Abstract Children with epilepsy can experience significant cognitive dysfunction that can lead to academic underachievement. Traditionally believed to be primarily due to the effects of factors such as the chronicity of epilepsy, medication effects, or the location of the primary epileptogenic lesion;, recent evidence has indicated that disruption of cognition-specific distributed neural networks may play a significant role as well. Specifically, over the last decade, researchers have begun to characterize the mechanisms underlying disrupted cognitive substrates by evaluating neural network abnormalities observed ...
Source: Epilepsy and Behaviour - August 6, 2019 Category: Neurology Authors: Oyegbile TO Tags: Epilepsy Behav Source Type: research

Reducing risks for pregnant women with epilepsy: A qualitative study exploring experiences of using a toolkit at the antenatal booking appointment.
CONCLUSION: Participants described lack of epilepsy knowledge and experience prior to using the 'toolkit' and how being prepared optimized its use. They articulated how it enabled them to collate the epilepsy and treatment history, share risk management strategies, and expedite referrals appropriately. They discussed how it increased confidence, reduced fear, and inspired motivation toward learning. The results of this study will provide a foundation for future research exploring the impact that the 'toolkit' has on multidisciplinary care provision. IMPLICATIONS FOR PRACTICE: This small study demonstrated the 'toolkit...
Source: Epilepsy and Behaviour - August 6, 2019 Category: Neurology Authors: Morley K Tags: Epilepsy Behav Source Type: research

Vascular risk factors as independent predictors of neurocognitive impairments in patients with late-onset epilepsy who have small-vessel disease.
CONCLUSIONS: Vascular risk factors and sociodemographic characteristics were the best predictors of cognitive outcomes in a sample of late-onset epilepsy with cerebral small-vessel disease. Epilepsy did not show influence on cognitive function. Longitudinal studies are necessary to clarify the relationship between vascular risk factors and epilepsy on progression of cognitive deterioration in patients with late-onset epilepsy. "This article is part of the Special Issue "Seizures & Stroke"". PMID: 31399342 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - August 6, 2019 Category: Neurology Authors: Turon M, Abraira L, Cazorla S, Fonseca E, Quintana M, Toledo M, Salas-Puig X, Santamarina E Tags: Epilepsy Behav Source Type: research

Neurobiology of organophosphate-induced seizures.
This article is part of the Special Issue"Proceedings of the 7th London-Innsbruck Colloquium on Status Epilepticus and Acute Seizures". PMID: 31399343 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - August 6, 2019 Category: Neurology Authors: Williamson J, Singh T, Kapur J Tags: Epilepsy Behav Source Type: research

Pediatric emergency department visit characteristics of the patients on the ketogenic diet.
uml;nalp A, Yılmaz Ü, Apa H Abstract BACKGROUND: The ketogenic diet (KD) has been frequently used for the patients with drug-resistant epilepsy in recent years. The management of these patients in emergency departments (EDs) has some difficulties due to the special needs of KD. We aimed to determine the characteristics and the management of the patients on the KD in the pediatric ED setting. METHODS: Patients who were on the KD and admitted to the ED were included in the study. Demographic, clinical, and laboratory data of all patients were retrospectively reviewed and recorded. RESULTS: There were...
Source: Epilepsy and Behaviour - August 6, 2019 Category: Neurology Authors: Çağlar A, Edizer S, Sarıtaş S, Çelebi Çelik F, Önder M, Er A, Ulusoy E, Akgül F, Ünalp A, Yılmaz Ü, Apa H Tags: Epilepsy Behav Source Type: research

Panayiotopoulos syndrome and Gastaut syndrome are distinct entities in terms of neuropsychological findings.
CONCLUSION: Using neuropsychological profiles, this study demonstrated that the GS and the PS are two distinct entities. Cognitive dysfunction is a more prominent and widespread feature of the patients with PS; whereas, the patients with GS suffer only from milder and isolated cognitive problems. PMID: 31398558 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - August 6, 2019 Category: Neurology Authors: Akca Kalem S, Elmali AD, Demirbilek V, Oktem O, Yapici Z, Saltik S, Gokcay A, Dervent A, Baykan B Tags: Epilepsy Behav Source Type: research

The co-occurrence of epilepsy and autism: A systematic review.
CONCLUSIONS: The period prevalence of epilepsy in people with autism, and vice versa, was consistently higher than previously reported estimates of the occurrence of these disorders in the general population. These findings highlight the importance of screening for autism in people who have epilepsy and epilepsy in people who have autism and may help shed light on shared pathogenesis between these conditions. PMID: 31398688 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - August 6, 2019 Category: Neurology Authors: Lukmanji S, Manji SA, Kadhim S, Sauro KM, Wirrell EC, Kwon CS, Jetté N Tags: Epilepsy Behav Source Type: research

Cognitive and behavioral effects of brief seizures in mice.
Abstract Comorbidities associated with epilepsy greatly reduce patients' quality of life. Since antiepilepsy drugs show limited success in ameliorating cognitive and behavioral symptoms, there is a need to better understand the mechanisms underlying epilepsy-related cognitive and behavioral impairments. Most prior research addressing this problem has focused on chronic epilepsy, wherein many factors can simultaneously impact cognition and behavior. The purpose of the present study was to develop a testing paradigm using mice that can provide new insight into how short-term biological changes underlying acute seizu...
Source: Epilepsy and Behaviour - August 6, 2019 Category: Neurology Authors: Batterman AI, DeChiara J, Islam A, Brenner MB, Fischer BD, Buono RJ, Keck TM, Ferraro TN Tags: Epilepsy Behav Source Type: research

Self-management skills and behaviors, self-efficacy, and quality of life in people with epilepsy from underserved populations.
CONCLUSION: This study identifies the unique epilepsy SM needs of PWE from underserved populations. We discuss the need for a personalized approach for developing SM skills and behaviors among these PWE. PMID: 31398690 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - August 6, 2019 Category: Neurology Authors: Pandey DK, Levy J, Serafini A, Habibi M, Song W, Shafer PO, Loeb JA Tags: Epilepsy Behav Source Type: research

Corpus callosotomy for drug-resistant spasms associated with tuberous sclerosis complex.
CONCLUSION: Total CC resulted in freedom from drug-resistant epileptic or tonic spasms in several patients with TSC. Stepwise progression from CC to additional resection or disconnection surgery may aid in the treatment of spasms secondary to TSC. PMID: 31394351 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - August 5, 2019 Category: Neurology Authors: Okanishi T, Fujimoto A, Okanari K, Baba S, Ichikawa N, Nishimura M, Enoki H Tags: Epilepsy Behav Source Type: research

The safety, tolerability, and effectiveness of PTL-101, an oral cannabidiol formulation, in pediatric intractable epilepsy: A phase II, open-label, single-center study.
Abstract INTRODUCTION: Several works have reported on the antiepileptic impact of cannabis-based preparations in patients with treatment-resistant epilepsy (TRE). However, current formulations suffer from low bioavailability and side effects. PTL-101, an oral formulation containing highly purified cannabidiol (CBD) embedded in seamless gelatin matrix beadlets was designed to enhance bioavailability and maintain a constant gastrointestinal transit time. METHODS: This phase II, prospective study was open to pediatric patients with TRE on stable antiepileptic drugs' (AEDs) doses, who experienced ≥4 seizures w...
Source: Epilepsy and Behaviour - August 5, 2019 Category: Neurology Authors: Mitelpunkt A, Kramer U, Hausman Kedem M, Zilbershot Fink E, Orbach R, Chernuha V, Fattal-Valevski A, Deutsch L, Heffetz D, Sacks H Tags: Epilepsy Behav Source Type: research

Increased CSF tau is associated with a higher risk of seizures in patients with Alzheimer's disease.
iras I, Santana I Abstract INTRODUCTION: Neurofibrillary tangles and tau protein, the neuropathological hallmarks of Alzheimer's disease (AD), have been identified in patients with epilepsy. Tau protein was also associated with the modulation of neuronal excitability in animal models of AD. MATERIALS AND METHODS: We evaluated in 292 patients with AD the association between the risk of seizure development and AD cerebrospinal fluid (CSF) biomarkers, demographic characteristics, baseline Mini-Mental State Examination (MMSE) score, comorbidities, and apolipoprotein E status. RESULTS: The development of seiz...
Source: Epilepsy and Behaviour - August 2, 2019 Category: Neurology Authors: Tábuas-Pereira M, Durães J, Lopes J, Sales F, Bento C, Duro D, Santiago B, Almeida MR, Leitão MJ, Baldeiras I, Santana I Tags: Epilepsy Behav Source Type: research

Personality traits, illness behaviors, and psychiatric comorbidity in individuals with psychogenic nonepileptic seizures (PNES), epilepsy, and other nonepileptic seizures (oNES): Differentiating between the conditions.
CONCLUSIONS: This study provides an important stepping stone in the understanding of demographic and seizure factors, personality domains, abnormal illness behaviors, and psychiatric comorbidity in the South African population with PNES. The study also reported on a cutoff score of 12 on the BAI-PC predicting PNES with 80% sensitivity and 89% specificity in a private hospital sample. PMID: 31382179 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - August 2, 2019 Category: Neurology Authors: Vilyte G, Pretorius C Tags: Epilepsy Behav Source Type: research

Timing of suicide in people with epilepsy: A population-based study from 18 states of the United States, 2003-2014.
Abstract Suicide timing varies across several psychiatric disorders, which may share common underlying pathophysiological mechanisms with epilepsy. We investigated suicide timing in people with epilepsy. Using cross-sectional, population-based U.S. National Violent Death Reporting System data from 2003 through 2014 in 18 States, we identified 1310 suicides with epilepsy and 102,582 suicides without epilepsy among those 10 years and older. We compared patterns of suicide mortality ratios between those with and without epilepsy by month of year, week of month, day of week, time of day, and overall by age, sex, and...
Source: Epilepsy and Behaviour - August 2, 2019 Category: Neurology Authors: Tian N, Zack MM, Hesdorffer DC Tags: Epilepsy Behav Source Type: research

Drug-resistant epilepsy: From multiple hypotheses to an integral explanation using preclinical resources.
This article is part of the Special Issue "NEWroscience 2018". PMID: 31378558 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - August 1, 2019 Category: Neurology Authors: Pérez-Pérez D, Frías-Soria CL, Rocha L Tags: Epilepsy Behav Source Type: research

Reactive oxygen species in status epilepticus.
Abstract There has been growing evidence for a critical role of oxidative stress in neurodegenerative disease, providing novel targets for disease modifying treatments. Although antioxidants have been suggested and tried in the treatment of epilepsy, it is only recently that the pivotal role of oxidative stress in the pathophysiology of status epilepticus has been recognized. Although conventionally thought to be generated by mitochondria, reactive oxygen species during status epilepticus and prolonged seizure are generated mainly by NADPH (nicotinamide adenine dinucleotide phosphate) oxidase (stimulated by NMDA r...
Source: Epilepsy and Behaviour - August 1, 2019 Category: Neurology Authors: Shekh-Ahmad T, Kovac S, Abramov AY, Walker MC Tags: Epilepsy Behav Source Type: research

Drug-drug interactions with cannabidiol (CBD) appear to have no effect on treatment response in an open-label Expanded Access Program.
CONCLUSION: These analyses suggest that concomitant to CBD, AEDs may not have an effect on reducing seizure frequency and severity in patients with TRE. PMID: 31382177 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - August 1, 2019 Category: Neurology Authors: Gaston TE, Bebin EM, Cutter GR, Ampah SB, Liu Y, Grayson LP, Szaflarski JP, UAB CBD Program Tags: Epilepsy Behav Source Type: research

Chronic exercise buffers the cognitive dysfunction and decreases the susceptibility to seizures in PTZ-treated rats.
Abstract Epilepsy is a serious neurological disorder posing a severe burden to our society. Cognitive deficits are very common comorbidities of epilepsy. It is known that enhanced cognition has been demonstrated as an indicator for successful treatment of epilepsy. Physical exercise shows a positive consequence on cognition in healthy individuals and improves health and life conditions in people with epilepsy. However, there is no direct evidence to determine the role and the potential mechanism of physical exercise on the cognitive impairment and the relationship of susceptibility to seizures. The goal of the cur...
Source: Epilepsy and Behaviour - August 1, 2019 Category: Neurology Authors: Lin XY, Cui Y, Wang L, Chen W Tags: Epilepsy Behav Source Type: research

Seizure detection watch improves quality of life for adolescents and their families.
This article reports the findings from a pilot study conducted to explore the impact of using a wearable seizure detection device on quality of life for 10 adolescents with epilepsy and their parents. Quality of life in Epilepsy for Adolescent (QOLIE AD-48) and the Parent Response to Child Illness (PRCI) Scale were compared at study onset and 6 months after using the SmartWatch seizure detection device. At the conclusion of the study, a qualitative interview explored the adolescent's and parent's experiences with using the device. In this sample, the wearable seizure detection device was well accepted as a means to incre...
Source: Epilepsy and Behaviour - August 1, 2019 Category: Neurology Authors: Thompson ME, Langer J, Kinfe M Tags: Epilepsy Behav Source Type: research

Psychogenic nonepileptic seizures treated with psychotherapy: Long-term outcome on seizures and healthcare utilization.
CONCLUSION: This study adds to the evidence that psychotherapy is a cost-effective way of treating PNES. The economic benefits from this form of intervention appear not only to diminish costs directly associated with PNES, but also healthcare utilization in general. PMID: 31377661 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - August 1, 2019 Category: Neurology Authors: Deleuran M, Nørgaard K, Andersen NB, Sabers A Tags: Epilepsy Behav Source Type: research

Prevalence, clinical characteristics, and seizure outcomes of epilepsy due to calcific clinical stage of neurocysticercosis: Study in a rural community in south India.
The objective of this research was to study the prevalence, clinical characteristics, and seizure remission rates of epilepsy due to calcific stage of neurocysticercosis (cNCC) in a rural community in south India. MATERIAL AND METHODS: Comprehensive Rural Epilepsy Study South India (CRESSI) is a prospective longitudinal study of epilepsy care in a rural community in south India. As part of this study, prevalence of epilepsy was studied in a population of 74,086 in 22 villages. The prevalence study identified 451 people with epilepsy including 62 (13.7%) with epilepsy due to cNCC. Diagnosis of cNCC was based on compute...
Source: Epilepsy and Behaviour - July 31, 2019 Category: Neurology Authors: Murthy JMK, Seshadri V Tags: Epilepsy Behav Source Type: research

Commentary on "Predicting seizure freedom after epilepsy surgery, a challenge in clinical practice".
Commentary on "Predicting seizure freedom after epilepsy surgery, a challenge in clinical practice". Epilepsy Behav. 2019 Jul 30;:106408 Authors: Goldenholz D, Sun H, Westover B PMID: 31375412 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - July 30, 2019 Category: Neurology Authors: Goldenholz D, Sun H, Westover B Tags: Epilepsy Behav Source Type: research

Theory of mind across lifespan from ages 16 to 81  years.
CONCLUSIONS: Theory of mind is a specific cognitive domain independent of age and formal education, but related to gender. Working memory, executive functions, and reality examination support some ToM processes. These findings may provide reference points against which impairment can be assessed. This article is part of the Special Issue "Epilepsy and social cognition across the lifespan". PMID: 31375413 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - July 30, 2019 Category: Neurology Authors: Giovagnoli AR Tags: Epilepsy Behav Source Type: research

Serum neurofilament light chain as a prognostic marker in postanoxic encephalopathy.
Abstract Functional outcome in patients with postanoxic encephalopathy after cardiac arrest (CA) often remains unclear, and there is a strong need of new prognostication measures. We aimed at investigating serum neurofilament light (NfL) chain concentration in patients with a postanoxic encephalopathy after CA and its prognostic potential. Serum samples were prospectively collected at different time points after CA in consecutive patients admitted to the intensive care unit (ICU) of Ticino Cardiocentre (Lugano, Switzerland) between June 2017 and March 2018. Serum NfL concentration was measured using a single molec...
Source: Epilepsy and Behaviour - July 30, 2019 Category: Neurology Authors: Disanto G, Prosperetti C, Gobbi C, Barro C, Michalak Z, Cassina T, Kuhle J, Casso G, Agazzi P Tags: Epilepsy Behav Source Type: research

Learnings from supporting traumatic grief in the aftermath of sudden epilepsy deaths.
Abstract The majority of epilepsy deaths are sudden, unexpected, and most prevalent among young adults. The number of people affected by a death can be high, as extended family and social networks survive. Those bereaved are at risk of developing traumatic and complex grief reactions and need access to specialist bereavement support as soon as possible after a death. It helps bereaved families to know how the death happened. They want lessons to be learnt and deaths to be prevented in future. The process of investigation into the death - which can contribute to these aims - may alienate families if not handled wel...
Source: Epilepsy and Behaviour - July 30, 2019 Category: Neurology Authors: Cowdry T, Stirling J Tags: Epilepsy Behav Source Type: research