What do patients prefer their functional seizures to be called, and what are their experiences of diagnosis? - A mixed methods investigation
This study explored the preferred terms for functional seizures, and the experience of being diagnosed, from the patient's perspective. 39 patients in a neuropsychiatry service diagnosed with functional seizures completed an online survey to investigate preferences for, and offensiveness of, 11 common diagnostic terms used to describe functional seizures. Of these 39 patients, 13 consented to take part in a semistructured interview exploring the experience of receiving a diagnosis. Nonepileptic attack disorder (NEAD), functional seizures, functional nonepileptic attacks (FNEA), and dissociative seizures were ranked the hig...
Source: Epilepsy and Behaviour - February 23, 2021 Category: Neurology Authors: Alana Loewenberger Karuna Davies Niruj Agrawal Norman Poole Sarah R Cope Source Type: research

Medication adherence, utilization of healthcare services, and mortality of patients with epilepsy on opiate replacement therapy: A retrospective cohort study
Epilepsy Behav. 2021 Feb 20;117:107829. doi: 10.1016/j.yebeh.2021.107829. Online ahead of print.ABSTRACTINTRODUCTION: Substance misuse is not uncommonly recognized in people with epilepsy (PWE). Mortality is significantly greater in those with comorbid substance misuse, but it remains unclear whether epilepsy care and management contribute to this. This cohort study aimed to compare the rates of mortality in PWE receiving opiate replacement therapy (ORT) and PWE alone, as well as evaluate their medication adherence, levels of engagement with epilepsy services as currently delivered, and utilization of unscheduled hospital ...
Source: Epilepsy and Behaviour - February 23, 2021 Category: Neurology Authors: Amber Askarieh Ian Morrison Kevin Ross Colin McCowan Keith Matthews Brian Kidd Craig A Heath Source Type: research

Shuddering attacks in children: A retrospective analysis of 19 cases from a single-center in Turkey
CONCLUSION: We speculate that there might be an indirect link between SA and teething and teething may be a triggering or an aggravating factor for SA.PMID:33621812 | DOI:10.1016/j.yebeh.2021.107827 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - February 23, 2021 Category: Neurology Authors: Selcan Ozturk Yakup Peduk Hakan Gumus Huseyin Per Source Type: research

Levetiracetam, perampanel, and the issue of aggression: A self-report study
This study investigated to which degree levetiracetam (LEV) and perampanel (PER), antiseizure medications (ASM) that are both known to cause aggression and irritability, share the same or different, behavioral side-effect profiles. In this self-report study, 68 participants with epilepsy treated with LEV (n = 35) or PER (n = 33) as part of their medication were asked to rate their behavioral experience with the respective drug as positive, neutral, or negative. Results of a German adaptation of the Adverse Events Profile (AEP) and of the "FPZ", a German personality questionnaire, were analyzed as a function of dr...
Source: Epilepsy and Behaviour - February 23, 2021 Category: Neurology Authors: Randi von Wrede Carolin Meschede Fiona Brand Christoph Helmstaedter Source Type: research

Very long-term seizure outcome in frontal lobe epilepsy surgery
Epilepsy Behav. 2021 Feb 20;117:107848. doi: 10.1016/j.yebeh.2021.107848. Online ahead of print.NO ABSTRACTPMID:33621814 | DOI:10.1016/j.yebeh.2021.107848 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - February 23, 2021 Category: Neurology Authors: Sara Casciato Roberta Morace Pier Paolo Quarato Addolorata Mascia Alfredo D'Aniello Liliana G Grammaldo Vincenzo Esposito Giancarlo Di Gennaro Source Type: research

Evaluation of a self-management intervention for adults with epilepsy in Taiwan: A longitudinal randomized controlled trial
Epilepsy Behav. 2021 Feb 20;117:107845. doi: 10.1016/j.yebeh.2021.107845. Online ahead of print.ABSTRACTPURPOSE: Epilepsy is a neurological disease that causes recurrent seizures and can have a significant impact on a person's quality of life (QOL). A self-management intervention (SMI) can allow adults with epilepsy to modify behaviors in order to manage their seizures and evaluate the impact of medication and treatments on their daily lives. The purpose of this study was to investigate the effects of a SMI for adults with epilepsy.METHODS: This was a longitudinal randomized controlled trial. Adults with epilepsy between t...
Source: Epilepsy and Behaviour - February 23, 2021 Category: Neurology Authors: Hsiu-Fang Chen Yun-Fang Tsai Jun-Yu Fan Min-Chi Chen Mo-Song Hsi Mau-Sun Hua Source Type: research

The impact of the coronavirus disease (COVID-19) pandemic on outpatient epilepsy care: An analysis of physician practices in Germany
Epilepsy Behav. 2021 Feb 19;117:107833. doi: 10.1016/j.yebeh.2021.107833. Online ahead of print.ABSTRACTOBJECTIVE: To gain insight into epilepsy care during coronavirus disease (COVID-19) pandemic, we analyzed prescription data of a large cohort of persons with epilepsy (PWE) during lockdown in Germany.METHODS: Information was obtained from the Disease Analyzer database, which collects anonymous demographic and medical data from practice computer systems of general practitioners (GP) and neurologists (NL) throughout Germany. We retrospectively compared prescription data for anti-seizure medication (ASM) and physicians' not...
Source: Epilepsy and Behaviour - February 22, 2021 Category: Neurology Authors: Tamara M Mueller Karel Kostev Stephanie Gollwitzer Johannes D Lang Jenny Stritzelberger Vivien Westermayer Caroline Reindl Hajo M Hamer Source Type: research

Autism spectrum disorders of patients with epilepsy: The to-be-determined face of the coin
Epilepsy Behav. 2021 Feb 17:107838. doi: 10.1016/j.yebeh.2021.107838. Online ahead of print.NO ABSTRACTPMID:33610459 | DOI:10.1016/j.yebeh.2021.107838 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - February 21, 2021 Category: Neurology Authors: St éphane Auvin Source Type: research

Power and pragmatism in functional neurological disorder research
Epilepsy Behav. 2021 Feb 17:107810. doi: 10.1016/j.yebeh.2021.107810. Online ahead of print.NO ABSTRACTPMID:33610460 | DOI:10.1016/j.yebeh.2021.107810 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - February 21, 2021 Category: Neurology Authors: Richard A A Kanaan Daniela Huepe-Artigas Shimaa K Morsy Olivia L Carter Source Type: research

Underutilization of epilepsy surgery: Part I: A scoping review of barriers
Epilepsy Behav. 2021 Feb 18:107837. doi: 10.1016/j.yebeh.2021.107837. Online ahead of print.ABSTRACTOne-third of persons with epilepsy have seizures despite appropriate medical therapy. Drug resistant epilepsy (DRE) is associated with neurocognitive and psychological decline, poor quality of life, increased risk of premature death, and greater economic burden. Epilepsy surgery is an effective and safe treatment for a subset of people with DRE but remains one of the most underutilized evidence-based treatments in modern medicine. The reasons for this quality gap are insufficiently understood. In this comprehensive review, w...
Source: Epilepsy and Behaviour - February 21, 2021 Category: Neurology Authors: Debopam Samanta Adam P Ostendorf Erin Willis Rani Singh Satyanarayana Gedela Ravindra Arya M Scott Perry Source Type: research

Positive and negative effects of perampanel treatment on psychiatric and behavioral symptoms in adult patients with epilepsy
CONCLUSIONS: Perampanel therapy may aggravate or even ameliorate psychiatric and behavioral symptoms in patients with epilepsy. The psychiatric and behavioral prognoses after administration of PER vary depending on the type of psychiatric and behavioral comorbidities in patients with epilepsy. Psychiatric and behavioral symptoms may improve in patients with successful suppression of seizures by PER. Additionally, combination therapy consisting of PER and carbamazepine may be associated with good outcomes of psychiatric and behavioral symptoms in patients with epilepsy.PMID:33610462 | DOI:10.1016/j.yebeh.2020.107515 (Source...
Source: Epilepsy and Behaviour - February 21, 2021 Category: Neurology Authors: Naoya Hasegawa Jun Tohyama Source Type: research

Effect of seizure timing on long-term survival in patients with brain tumor
Epilepsy Behav. 2021 Feb 17:107566. doi: 10.1016/j.yebeh.2020.107566. Online ahead of print.NO ABSTRACTPMID:33610463 | DOI:10.1016/j.yebeh.2020.107566 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - February 21, 2021 Category: Neurology Authors: Suyash Singh Anant Mehrotra Soumen Kanjilal Vimal K Paliwal Source Type: research

Home video prediction of epileptic vs. nonepileptic seizures in US veterans
This study demonstrated that home videos of paroxysmal events could be an important tool in reliably diagnosing ES vs. PNES in veterans referred for evaluation of epilepsy when interpreted by experts. A moderate inter-rater reliability was observed in this study.PMID:33611097 | DOI:10.1016/j.yebeh.2021.107811 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - February 21, 2021 Category: Neurology Authors: Cemal Karakas Yosefa Modiano Paul C Van Ness Jay R Gavvala Vitor Pacheco Melissa Fadipe Sikawat Thanaviratananich Ammar M Alobaidy Abhishek Purohit Steven Fussner David K Chen Zulfi Haneef Source Type: research

Complementary and alternative medicine in epilepsy: A global survey of physicians' opinions
CONCLUSION: Although the evidence supporting the use of CAM for the treatment of epilepsy is extremely sparse, most physicians worldwide believe that it could be integrated with the use of conventional ASMs, at least in some patients. High-quality controlled trials are warranted to provide robust evidence on the usefulness of CAM options in PWE.PMID:33611098 | DOI:10.1016/j.yebeh.2021.107835 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - February 21, 2021 Category: Neurology Authors: Ali A Asadi-Pooya Francesco Brigo Simona Lattanzi Ioannis Karakis Marjan Asadollahi Eugen Trinka Lobna Talaat El Ghoneimy Chrisma Pretorius Guilca Contreras Anilu Daza-Restrepo Kette Valente Luciana D'Alessio Saule T Turuspekova Ghaieb Aljandeel Samson Kh Source Type: research

Temporal lobe dysfunction in late-onset epilepsy of unknown origin
Epilepsy Behav. 2021 Feb 18;117:107839. doi: 10.1016/j.yebeh.2021.107839. Online ahead of print.ABSTRACTOBJECTIVE: Epilepsy with onset in the adulthood is an increasing health problem, due to the progressive aging of the worldwide population. Whether the causes remain undetermined, the disease is defined as Late-Onset Epilepsy of Unknown origin (LOEU). The aim of this study was to evaluate the semiological, electroencephalographic, metabolic, and neuropsychological features of LOEU.METHODS: We selected patients with late-onset epilepsy (LOE) (≥55 years), whose causes of the disease have been excluded with a deep clinica...
Source: Epilepsy and Behaviour - February 21, 2021 Category: Neurology Authors: Jacopo C DiFrancesco Valeria Isella Daniele Licciardo Cinzia Crivellaro Monica Musarra Luca Guerra Nicola Salvadori Elena Chipi Carmen Calvello Cinzia Costa Carlo Ferrarese Source Type: research

When my patient tells me "YOU DON'T KNOW how it feels not to be able to drive for 6  months!!"
Epilepsy Behav. 2021 Feb 18;117:107831. doi: 10.1016/j.yebeh.2021.107831. Online ahead of print.NO ABSTRACTPMID:33611100 | DOI:10.1016/j.yebeh.2021.107831 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - February 21, 2021 Category: Neurology Authors: Maria Raquel Lopez Source Type: research

Regional and global resting-state functional MR connectivity in temporal lobe epilepsy: Results from the Epilepsy Connectome Project
Epilepsy Behav. 2021 Feb 18;117:107841. doi: 10.1016/j.yebeh.2021.107841. Online ahead of print.ABSTRACTTemporal lobe epilepsy (TLE) has been conceptualized as focal disease with a discrete neurobiological focus and can respond well to targeted resection or ablation. In contrast, the neuro-cognitive deficits resulting from TLE can be widespread involving regions beyond the primary epileptic network. We hypothesize that this seemingly paradoxical findings can be explained by differences in connectivity between the primary epileptic region which is hyper-connected and its secondary influence on global connectome organization...
Source: Epilepsy and Behaviour - February 21, 2021 Category: Neurology Authors: Aaron F Struck Melanie Boly Gyujoon Hwang Veena Nair Jedidiah Mathis Andrew Nencka Lisa L Conant Edgar A DeYoe Manoj Ragahavan Vivek Prabhakaran Jeffrey R Binder Mary E Meyerand Bruce P Hermann Source Type: research

Safety, efficacy, and tolerability of lacosamide for the treatment of epilepsy in pediatric patients in Uygur, China
Epilepsy Behav. 2021 Feb 18;117:107814. doi: 10.1016/j.yebeh.2021.107814. Online ahead of print.ABSTRACTPURPOSE: Lacosamide (LCM) was approved in China in 2018. However, the safety of LCM has not been established in pediatric patients. Therefore, the objective of this study was to investigate its safety, efficacy, and tolerability in pediatric patients living in Uygur, Northwest China.METHODS: This is a retrospective analysis of pediatric patients diagnosed with epilepsy and on LCM therapy at a medical center. The seizure frequencies at 3, 6, and 12 months after starting LCM therapy were recorded and compared with the base...
Source: Epilepsy and Behaviour - February 21, 2021 Category: Neurology Authors: Ting Zhao Hong-Jian Li Long Ma Jie Feng Ting-Ting Wang Jing Yu Li Sun Yan Sun Lu-Hai Yu Source Type: research

Resting-state hippocampal networks related to language processing reveal unique patterns in temporal lobe epilepsy
Epilepsy Behav. 2021 Feb 17;117:107834. doi: 10.1016/j.yebeh.2021.107834. Online ahead of print.ABSTRACTOBJECTIVE: Patients with temporal lobe epilepsy (TLE) commonly experience a broad range of language impairments. These deficits are thought to arise from repeated seizure activity that damages language regions. However, connectivity between the seizure onset region in the hippocampus and regions related to language processing has rarely been studied, and could also have a strong impact on language function. The purpose of this study was to use resting-state functional connectivity (FC) measures to assess hippocampal netw...
Source: Epilepsy and Behaviour - February 20, 2021 Category: Neurology Authors: Allison Whitten Monica L Jacobs Dario J Englot Baxter P Rogers Kaela K Levine Hern án F J González Victoria L Morgan Source Type: research

Developmental outcome after corpus callosotomy for infants and young children with drug-resistant epilepsy
Epilepsy Behav. 2021 Feb 17;117:107799. doi: 10.1016/j.yebeh.2021.107799. Online ahead of print.ABSTRACTAIM: To examine the developmental and seizure outcomes after corpus callosotomy (CC) in early childhood.METHODS: We retrospectively identified 106 patients who underwent CC for drug-resistant epilepsy before the age of 6 years, at the Nagasaki Medical Center, between July 2002 and July 2016. Patients' developmental outcomes were evaluated one year after CC using the Kinder Infant Development Scale.RESULTS: The mean preoperative developmental quotient (DQ) was 25.0 (standard deviation [SD], 20.8), and the mean difference ...
Source: Epilepsy and Behaviour - February 20, 2021 Category: Neurology Authors: Ryoko Honda Hiroshi Baba Kohei Adachi Rika Koshimoto Tomonori Ono Keisuke Toda Shigeki Tanaka Shiro Baba Kazumi Yamasaki Hiroshi Yatsuhashi Source Type: research

The psychiatric effects of ketogenic diet therapy on adults with chronic epilepsy
This study provides preliminary evidence that KDT may have a positive impact on psychological state independent of seizure reduction or ketone body production and may be influenced by longer duration of diet therapy. These results support further investigation into specific effects and potential therapeutic benefits on various psychiatric disorders.PMID:33610104 | DOI:10.1016/j.yebeh.2021.107807 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - February 20, 2021 Category: Neurology Authors: Abigail Shegelman Kathryn A Carson Tanya J W McDonald Bobbie J Henry-Barron Luisa A Diaz-Arias Mackenzie C Cervenka Source Type: research

Short-term outcomes in pediatric and adolescent patients with psychogenic nonepileptic events seen by telemedicine during the COVID-19 pandemic
CONCLUSIONS: Video telemedicine visits are a feasible and effective way to provide care for children and adolescents with PNEE. At 3 months, patients seen by telemedicine had similar acceptance rates, decreased connection to counseling, and increased rate of improvement in event frequency. This study suggests telemedicine may have some benefits over traditional clinic visits, such as improved show rates and access to clinic; so should be considered a reasonable alternative to in-person visits.PMID:33601287 | DOI:10.1016/j.yebeh.2020.107739 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - February 18, 2021 Category: Neurology Authors: Megan Fredwall Debbie Terry Laurie Enciso Maggie Mary Burch Kristen Trott Dara V F Albert Source Type: research

Resting-state hippocampal networks related to language processing reveal unique patterns in temporal lobe epilepsy.
an VL Abstract OBJECTIVE: Patients with temporal lobe epilepsy (TLE) commonly experience a broad range of language impairments. These deficits are thought to arise from repeated seizure activity that damages language regions. However, connectivity between the seizure onset region in the hippocampus and regions related to language processing has rarely been studied, and could also have a strong impact on language function. The purpose of this study was to use resting-state functional connectivity (FC) measures to assess hippocampal network patterns and their relation to language abilities in patients with right TLE...
Source: Epilepsy and Behaviour - February 17, 2021 Category: Neurology Authors: Whitten A, Jacobs ML, Englot DJ, Rogers BP, Levine KK, González HFJ, Morgan VL Tags: Epilepsy Behav Source Type: research

Developmental outcome after corpus callosotomy for infants and young children with drug-resistant epilepsy.
Abstract AIM: To examine the developmental and seizure outcomes after corpus callosotomy (CC) in early childhood. METHODS: We retrospectively identified 106 patients who underwent CC for drug-resistant epilepsy before the age of 6 years, at the Nagasaki Medical Center, between July 2002 and July 2016. Patients' developmental outcomes were evaluated one year after CC using the Kinder Infant Development Scale. RESULTS: The mean preoperative developmental quotient (DQ) was 25.0 (standard deviation [SD], 20.8), and the mean difference between preoperative DQ and one-year postoperative DQ was -1.6 points (S...
Source: Epilepsy and Behaviour - February 17, 2021 Category: Neurology Authors: Honda R, Baba H, Adachi K, Koshimoto R, Ono T, Toda K, Tanaka S, Baba S, Yamasaki K, Yatsuhashi H Tags: Epilepsy Behav Source Type: research

The psychiatric effects of ketogenic diet therapy on adults with chronic epilepsy.
This study provides preliminary evidence that KDT may have a positive impact on psychological state independent of seizure reduction or ketone body production and may be influenced by longer duration of diet therapy. These results support further investigation into specific effects and potential therapeutic benefits on various psychiatric disorders. PMID: 33610104 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - February 17, 2021 Category: Neurology Authors: Shegelman A, Carson KA, McDonald TJW, Henry-Barron BJ, Diaz-Arias LA, Cervenka MC Tags: Epilepsy Behav Source Type: research

Short-term outcomes in pediatric and adolescent patients with psychogenic nonepileptic events seen by telemedicine during the COVID-19 pandemic.
CONCLUSIONS: Video telemedicine visits are a feasible and effective way to provide care for children and adolescents with PNEE. At 3 months, patients seen by telemedicine had similar acceptance rates, decreased connection to counseling, and increased rate of improvement in event frequency. This study suggests telemedicine may have some benefits over traditional clinic visits, such as improved show rates and access to clinic; so should be considered a reasonable alternative to in-person visits. PMID: 33601287 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - February 15, 2021 Category: Neurology Authors: Fredwall M, Terry D, Enciso L, Burch MM, Trott K, Albert DVF Tags: Epilepsy Behav Source Type: research

Psychogenic nonepileptic seizures: The effect of accurate diagnosis on cognition.
CONCLUSION: PNES patients showed improved cognition at 1 year of follow-up, particularly in language and executive functions. This finding shows the potential benefits of an early, accurate diagnosis, which range from improved cognition to better management. PMID: 33588318 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - February 12, 2021 Category: Neurology Authors: Cáceres C, Grau-López L, Martínez S, Mariscal C, González-Fuxà A, Jiménez M, Ciurans J, Gea M, Fumanal A, Becerra JL Tags: Epilepsy Behav Source Type: research

Establishing a learning healthcare system to improve health outcomes for people with epilepsy.
Abstract OBJECTIVE: To describe the organization of the Epilepsy Learning Healthcare System (ELHS), a network that aims to improve care outcomes for people with epilepsy (PWE). MATERIALS AND METHODS: Patients and family partners, providers, researchers, epidemiologists, and other leaders collaborated to recruit epilepsy centers and community services organizations into a novel learning network. A multidisciplinary Coordinating Committee developed ELHS governance and organizational structure, including four key planning Cores (Community, Clinical, Quality Improvement, and Data). Through Quality Improvement (QI...
Source: Epilepsy and Behaviour - February 12, 2021 Category: Neurology Authors: Donahue MA, Herman ST, Dass D, Farrell K, Kukla A, Abend NS, Moura LMVR, Buchhalter JR, Fureman BE Tags: Epilepsy Behav Source Type: research

Climate change and epilepsy: Insights from clinical and basic science studies.
Abstract Climate change is with us. As professionals who place value on evidence-based practice, climate change is something we cannot ignore. The current pandemic of the novel coronavirus, SARS-CoV-2, has demonstrated how global crises can arise suddenly and have a significant impact on public health. Global warming, a chronic process punctuated by acute episodes of extreme weather events, is an insidious global health crisis needing at least as much attention. Many neurological diseases are complex chronic conditions influenced at many levels by changes in the environment. This review aimed to collate and evalu...
Source: Epilepsy and Behaviour - February 9, 2021 Category: Neurology Authors: Gulcebi MI, Bartolini E, Lee O, Lisgaras CP, Onat F, Mifsud J, Striano P, Vezzani A, Hildebrand MS, Jimenez-Jimenez D, Junck L, Lewis-Smith D, Scheffer IE, Thijs RD, Zuberi SM, Blenkinsop S, Fowler HJ, Foley A, Sisodiya SM, EpilepsyClimateChange Consortiu Tags: Epilepsy Behav Source Type: research

The development and efficacy of a mobile phone application to improve medication adherence for persons with epilepsy in limited resource settings: A preliminary study.
This study validates a novel mobile application which was hypothesized to increase medication adherence and self-management skills in PWE. Created by medical professionals, the application included behavioral and educational components and was built to be easy-to-understand for those of socio-economically disadvantaged backgrounds. METHODS: This was a parallel, two-armed randomized controlled trial in which a total of 96 participants were enrolled from a Neurology Outpatient Department into a control standard care group and a mobile application group that used the smartphone application (app) in addition to the standa...
Source: Epilepsy and Behaviour - February 9, 2021 Category: Neurology Authors: Mirpuri P, Chandra PP, Samala R, Agarwal M, Doddamani R, Kaur K, Ramanujan B, Chandra PS, Tripathi M Tags: Epilepsy Behav Source Type: research

Sex differences in anxiety in patients with epilepsy: Status and risk factors analysis.
CONCLUSION: Anxiety is a common psychiatric comorbidity among PWE. There were sex differences in the prevalence and risk factors for anxiety in patients. PMID: 33578225 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - February 9, 2021 Category: Neurology Authors: Zhong R, Chen Q, Li M, Li N, Zhang X, Lin W Tags: Epilepsy Behav Source Type: research

The probability of sudden unexpected death in epilepsy given postictal prone position.
Abstract Sudden Unexpected Death in Epilepsy (SUDEP) is strongly linked to prone position in the immediate aftermath of a generalized tonic-clonic seizure (GTCS). The risk of SUDEP after a GTCS resulting in prone position has not yet been estimated. We calculated the probability of SUDEP given prone position after a GTCS using Bayesian analysis with inputs obtained from known risk of SUDEP and probability of prone position after a GTCS. The risk for SUDEP given the prone position is estimated to be 0.41% (95% Credible Interval 0.13-0.69%). The relative risk of SUDEP in prone vs. non-prone position following a GTCS...
Source: Epilepsy and Behaviour - February 8, 2021 Category: Neurology Authors: Esmaeili B, Dworetzky BA, Glynn RJ, Lee JW Tags: Epilepsy Behav Source Type: research

Determinants of caregiver burden in male patients with epilepsy following penetrating traumatic brain injury.
CONCLUSION: Elevated PTE caregiver burden is persistent across the life span suggesting that caregivers could benefit from counseling and targeted psychosocial interventions to reduce their burden. PMID: 33567399 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - February 7, 2021 Category: Neurology Authors: Jabbarinejad R, Cohen-Zimerman S, Wagner AK, Grafman J Tags: Epilepsy Behav Source Type: research

Cenobamate treatment of focal-onset seizures: Quality of life and outcome during up to eight years of treatment.
We describe our experience optimizing cenobamate treatment for 49 patients treated at one center for up to eight years. We assessed the influence of treatment response on measurements of quality of life (QOLIE). Forty-nine patients were evaluated from three cenobamate regulatory trials: two open-label extensions of randomized placebo-controlled studies and one open-label safety study at the Johns Hopkins Hospital (JHU). Patients had focal-onset seizures despite treatment with one to three ASMs and were 18 years of age and older. Patients kept seizure diaries for the duration of the study and had tri-monthly evaluations. ...
Source: Epilepsy and Behaviour - February 7, 2021 Category: Neurology Authors: Elizebath R, Zhang E, Coe P, Gutierrez EG, Yang J, Krauss GL Tags: Epilepsy Behav Source Type: research

Evaluation of emergency department-based seizure and epilepsy education: Exploring the need for early epilepsy self-management intervention.
Abstract Many people with epilepsy (PWE) present to the emergency department setting with their first seizure and must wait weeks or months to be seen by a specialized epilepsy provider. The time period between presentation of first seizure and entry into specialized care can be extremely stressful and precarious for PWE and their families. In order to achieve optimal outcomes, epilepsy self-management should be initiated as soon as possible, including in the emergency department setting. The purpose of this study was to review and evaluate existing epilepsy/seizure-related education materials provided to patients...
Source: Epilepsy and Behaviour - February 6, 2021 Category: Neurology Authors: Miller WR, Wion RK, Eads P Tags: Epilepsy Behav Source Type: research

Bidirectional relationships of sleep and epilepsy in adults with epilepsy.
Abstract This targeted review addresses the best accepted and most intriguing recent observations on the complex relationships between sleep and epilepsy. Ten to 15% of all epilepsies are sleep-related. Included in these is sleep-related hypermotor epilepsy, renamed from nocturnal frontal lobe epilepsy by a 2016 consensus conference since 30% of cases are extra-frontal, seizures are related to sleep rather than clock time, and the predominant semiology is hypermotor. Stereo-EEG is providing crucial insights into network activation in sleep-related epilepsies and definition of the epileptogenic zone. Pathologic hig...
Source: Epilepsy and Behaviour - February 6, 2021 Category: Neurology Authors: Grigg-Damberger M, Foldvary-Schaefer N Tags: Epilepsy Behav Source Type: research

Vortioxetine increases absence-like seizures in WAG/Rij rats but decreases penicillin- and pentylenetetrazole-induced seizures in Wistar rats.
CONCLUSION: The results of this study suggested that vortioxetine has anticonvulsant activity in penicillin- and pentylenetetrazole-induced seizure models. However, it exhibited proconvulsant activity in the absence epileptic WAG/Rij rats. PMID: 33561766 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - February 5, 2021 Category: Neurology Authors: Aygun H, Ayyildiz M Tags: Epilepsy Behav Source Type: research

Feasibility of telephone-delivered therapy for common mental health difficulties embedded in pediatric epilepsy clinics.
CONCLUSION: A modular cognitive behavioral treatment delivered over the telephone by HCPs with limited experience of psychological therapy was feasible and effective in treating mental health problems in children and young people with epilepsy. Health-related Quality of Life also improved over the duration of treatment. A randomized controlled trial (RCT) is needed to demonstrate efficacy of the intervention. PMID: 33556861 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - February 5, 2021 Category: Neurology Authors: Bennett SD, Au C, Byford S, Chorpita B, Coughtrey AE, Cross JH, Dalrymple E, Fonagy P, Ford T, Heyman I, Lewins A, Moss-Morris R, Reilly C, Xu L, Shafran R Tags: Epilepsy Behav Source Type: research

Seizure focus in the frontal interhemispheric fissure leads to ipsilateral isolated eye deviation.
CONCLUSION: The present study is the first to demonstrate that seizures with an F-IHF focus tend to present with initial ipsilateral isolated ED. This finding may aid in identifying the seizure focus in patients with isolated ED prior to resection. PMID: 33556862 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - February 5, 2021 Category: Neurology Authors: Nishimura M, Okanishi T, Itamura S, Homma Y, Sakakura K, Ichikawa N, Limotai C, Yamada S, Baba S, Masuda Y, Enoki H, Fujimoto A Tags: Epilepsy Behav Source Type: research

Can semiology differentiate between bilateral tonic-clonic seizures of focal-onset and generalized-onset? A systematic review.
CONCLUSION: Focal signs are often evident in GOTCS. Though the observation of multiple focal signs within a given seizure may be in favor of an FBTCS, our findings caution against differentiating between the two seizure types based on semiology alone due to considerable overlap in focal features. PMID: 33556863 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - February 5, 2021 Category: Neurology Authors: Christie H, D'Souza W, Cook M, Seneviratne U Tags: Epilepsy Behav Source Type: research

Association between allergic diseases and epilepsy: A systematic review and meta-analysis.
CONCLUSION: Our findings suggest that patients with allergic diseases might have a high risk of epilepsy. Additional high-quality primary studies are required to confirm the association, obtain information regarding the mechanism of association, and determine prevention opportunities. PMID: 33556864 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - February 5, 2021 Category: Neurology Authors: He CH, Zhao J, Zhu TT Tags: Epilepsy Behav Source Type: research

A review of caregiver distress in epilepsy in India: Current issues and future directions for research.
Abstract India is home to a large number of individuals with epilepsy, with many of these patients having high care needs. Owing to limited infrastructural support and prevalent cultural attitudes, most of these individuals are cared for by their families. Such informal caregiving is often associated with poor physical and psychological outcomes, but the state of caregivers of people with epilepsy in India remains largely ignored. This review summarizes currently available research on distress among caregivers for people with epilepsy in India. A review of 20 studies published till July 2020 revealed significant b...
Source: Epilepsy and Behaviour - February 4, 2021 Category: Neurology Authors: Bapat DA, Shankar A Tags: Epilepsy Behav Source Type: research

Developing epilepsy training capacity for primary care providers using the project ECHO telementoring model.
CONCLUSIONS: We successfully piloted a telementoring program using Project ECHO methodology, which was effective in educating PCPs about epilepsy treatment. Combining epilepsy and other neurology topics was an effective strategy in garnering interest among PCPs, but additional methods are needed to encourage participants to present their own cases. PMID: 33549938 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - February 4, 2021 Category: Neurology Authors: McDonald SB, Privitera M, Kakacek J, Owens S, Shafer P, Kobau R Tags: Epilepsy Behav Source Type: research

Surgical targeting of large hypothalamic hamartomas and seizure-freedom following MR-guided laser interstitial thermal therapy.
CONCLUSION: Differences in the size, position, and anatomical localization of ablation volumes may be a potential contributor to the variability in postoperative outcomes of large HH treated with MRgLITT. A novel, high-resolution MRI atlas of the hypothalamus identifies a number of regions at the interface of large HH that are preferentially disconnected in seizure-free patients. This method of anatomical localization not only serves as a potential clinical tool for surgical targeting but may also provide novel insights into the mechanisms of epileptogenesis in hypothalamic hamartomas. PMID: 33549939 [PubMed - as supp...
Source: Epilepsy and Behaviour - February 4, 2021 Category: Neurology Authors: Mithani K, Neudorfer C, Boutet A, Germann J, Elias GJB, Weil AG, Donner E, Kalia S, Lozano AM, Drake JM, Widjaja E, Ibrahim GM Tags: Epilepsy Behav Source Type: research

Effects of sulthiame on seizure frequency and EEG in children with electrical status epilepticus during slow sleep.
In this study, we aimed to examine the efficiency and tolerability of sulthiame in ESES. METHODS: The data of 39 patients diagnosed as ESES and who received sulthiame as an additional treatment between 2016 and 2020 were reviewed retrospectively. Electroencephalographic (EEG) findings and seizure rates were compared before and after the sulthiame treatment. RESULTS: The mean age was 8.5 ± 4.1 (1.5-16 years). Nine out of 39 patients had benign childhood focal epilepsies. Structural causes were identified in 13 patients. The mean duration of sulthiame use was 32.5 ± 13.7 months. After sult...
Source: Epilepsy and Behaviour - February 4, 2021 Category: Neurology Authors: Topçu Y, Kılıç B, Tekin HG, Aydın K, Turanlı G Tags: Epilepsy Behav Source Type: research

Differences in levetiracetam and perampanel treatment-related irritability in patients with epilepsy.
CONCLUSIONS: LEV and PER cause irritability in different patient groups. Additionally, irritability as a side effect was present only at low dosages of LEV, but PER tended to cause irritability even at high dosages. PMID: 33549477 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - February 3, 2021 Category: Neurology Authors: Hasegawa N, Tohyama J Tags: Epilepsy Behav Source Type: research

Acthar ® Gel (repository corticotropin injection) dose-response relationships in an animal model of epileptic spasms.
Acthar® Gel (repository corticotropin injection) dose-response relationships in an animal model of epileptic spasms. Epilepsy Behav. 2021 Feb 03;116:107786 Authors: Le JT, Frost JD, Swann JW Abstract Studies were undertaken to evaluate the effectiveness of Acthar® Gel (repository corticotropin injection [RCI]) in the tetrodotoxin (TTX) model of early-life-induced epileptic spasms. Repository corticotropin injection (RCI) is widely used in the United States to treat infantile spasms. A major component of RCI is N25 deamidated ACTH. Additionally, we hoped to provide some insight into the possibl...
Source: Epilepsy and Behaviour - February 3, 2021 Category: Neurology Authors: Le JT, Frost JD, Swann JW Tags: Epilepsy Behav Source Type: research

The number and periodicity of seizures induce cardiac remodeling and changes in micro-RNA expression in rats submitted to electric amygdala kindling model of epilepsy.
Abstract Generalized tonic-clonic seizures (GTCS) are the main risk factor for sudden unexpected death in epilepsy (SUDEP). Also, among the several mechanisms underlying SUDEP there is the cardiac dysfunction. So, we aimed to evaluate the impact of the number of seizures on heart function and morphology in rats with epilepsy. Rats were randomized into three groups: Sham (without epilepsy), 5 S, and 10 S groups, referred as rats with epilepsy with a total of 5 or 10 GTCS, respectively. Epilepsy was induced by electrical amygdala kindling. The ventricular function was analyzed by the Langendorff technique and challe...
Source: Epilepsy and Behaviour - February 3, 2021 Category: Neurology Authors: Pansani AP, Ghazale PP, Dos Santos EG, Dos Santos Borges K, Gomes KP, Lacerda IS, Castro CH, Mendes EP, Dos Santos FCA, Biancardi MF, Nejm MB, Dogini DB, Rabelo LA, Nunes-Souza V, Scorza FA, Colugnati DB Tags: Epilepsy Behav Source Type: research

Distinguishing psychogenic nonepileptic, mixed, and epileptic seizures using systemic measures and reported experiences.
Abstract OBJECTIVES: Our primary objective was to better discern features that can differentiate people with 'mixed' symptomatology from those who experience epileptic seizures (ES) or functional/psychogenic nonepileptic seizures (PNES) alone, in a population of patients referred for video-telemetry. We wished to see if we could establish the prevalence of PNES in this population of interest as well as compare both objective (e.g. videotelemetry reports and heart rate measurements) and subjective, patient-centered measures (reported symptoms and experiences). METHODS: Data were sourced from a database of all ...
Source: Epilepsy and Behaviour - February 2, 2021 Category: Neurology Authors: Deli A, Huang YG, Toynbee M, Towle S, Adcock JE, Bajorek T, Okai D, Sen A Tags: Epilepsy Behav Source Type: research

Validation of a predictive calculator to distinguish between patients presenting with dissociative versus epileptic seizures.
Abstract Dissociative seizures (also known as psychogenic nonepileptic seizures) are a common functional neurological disorder that can be difficult to distinguish from epileptic seizures. Patients with dissociative seizures provide diagnostic challenges, leading to delays in care, inappropriate care, and significant healthcare utilization and associated costs. The dissociative seizure likelihood score (DSLS) was developed by Kerr and colleagues at UCLA to distinguish between patients with epileptic seizures and dissociative seizures based on clinical and medication history as well as features of seizure semiology...
Source: Epilepsy and Behaviour - February 2, 2021 Category: Neurology Authors: Lenio S, Kerr WT, Watson M, Baker S, Bush C, Rajic A, Strom L Tags: Epilepsy Behav Source Type: research