The refractory epilepsy screening tool for Lennox-Gastaut syndrome (REST-LGS).
CONCLUSIONS: The combined number of major/minor criteria on the CRF may be particularly indicative of LGS. Therefore, the REST-LGS may be a valuable clinical tool in identifying patients requiring further diagnostic evaluation for LGS. PMID: 30537670 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - December 8, 2018 Category: Neurology Authors: Piña-Garza JE, Boyce D, Tworek DM, Davis KA, Gatens H, Lai G, McGoldrick PE, Thomas B, Wolf SM Tags: Epilepsy Behav Source Type: research

Executive functioning phenotypes in youth with epilepsy.
The objectives of this study were to identify executive functioning (EF) phenotypes in youth with epilepsy and to examine whether phenotypes differ on psychosocial and medical outcomes (i.e., absence/presence of seizures in the past three months), health-related quality of life (HRQOL), and emotional and behavioral functioning. METHODS: Youth 5-18 years with diagnosed epilepsy and caregivers completed a battery of questionnaires as part of a larger national validation of the Pediatric Quality of Life (PedsQL) Epilepsy Module. The primary measure of interest was the Behavior Rating Inventory of Executive Function-Par...
Source: Epilepsy and Behaviour - December 7, 2018 Category: Neurology Authors: Modi AC, Gutierrez-Colina AM, Wagner JL, Smith G, Junger K, Huszti H, Mara CA Tags: Epilepsy Behav Source Type: research

Risk factors for the use of antiepileptic drugs in patients with psychogenic nonepileptic seizures.
CONCLUSIONS: Patients with PNES are at great risk of receiving unnecessary AEDs, and some patients' historical factors (e.g., urine incontinence) have a strong association with this practice. PMID: 30530132 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - December 7, 2018 Category: Neurology Authors: Asadi-Pooya AA, Bahrami Z Tags: Epilepsy Behav Source Type: research

Psychosocial complications in juvenile myoclonic epilepsy.
Abstract Juvenile myoclonic epilepsy (JME) constitutes about 10% of all epilepsies. Because of executive dysfunction, people with JME may be prone to impulsivity and risk-taking behavior. Our aim was to investigate whether psychosocial issues associated with impulsivity are more prominent in people with JME than in those with other types of genetic generalized epilepsy (GGE). Patients with GGE were recruited retrospectively through the Drammen Hospital records in Buskerud County, Norway, 1999-2013. They were invited to a semi-structured interview, either at the hospital or at home. Ninety-two patients with JME and...
Source: Epilepsy and Behaviour - December 7, 2018 Category: Neurology Authors: Syvertsen M, Selmer K, Enger U, Nakken KO, Pal DK, Smith A, Koht J Tags: Epilepsy Behav Source Type: research

Brivaracetam in adults with drug-resistant epilepsy and psychiatric comorbidities.
Abstract This is a case series of 25 patients with drug-resistant epilepsy and psychiatric comorbidities who started on brivaracetam (BRV) at St George's University Hospitals and Frimley Health in London. Median BRV dose was 150 mg for a median follow-up period of 8 months. Twenty had focal epilepsy, four had generalized epilepsies, and one had unclassified epilepsy; 76% had mood disorders (either depression or bipolar disorder), 12% intellectual disabilities with autism spectrum disorder and challenging behavior, and 12% psychoses. Forty percent of patients presented at least 50% seizure reduction, but none o...
Source: Epilepsy and Behaviour - December 7, 2018 Category: Neurology Authors: Theochari E, Cock H, Lozsadi D, Galtrey C, Arevalo J, Mula M Tags: Epilepsy Behav Source Type: research

High risk of anxiety and depression in caregivers of adult patients with epilepsy and its negative impact on patients' quality of life.
CONCLUSION: Caregivers of adult PWE are at high risk of experiencing anxiety and depression. Caregiver psychological status, especially depression, was an independent predictor of poorer QOL for adult PWE. PMID: 30530135 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - December 7, 2018 Category: Neurology Authors: Zhu XR, Zhao T, Gu H, Gao YJ, Wang N, Zhao P, Chen YN, Han X, He GN, Li MM, Ma BQ, Yang SJ Tags: Epilepsy Behav Source Type: research

Circulating levels of adipokines are altered in patients with temporal lobe epilepsy.
CONCLUSIONS: These results corroborate the view that TLE is a multisystemic condition associated with low-grade inflammation. PMID: 30530136 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - December 7, 2018 Category: Neurology Authors: Toscano ECB, Lessa JMK, Gonçalves AP, Rocha NP, Giannetti AV, de Oliveira GN, Rachid MA, Vieira ÉLM, Teixeira AL Tags: Epilepsy Behav Source Type: research

Measurement equivalence of the short-form Quality of Life in Childhood Epilepsy Questionnaire (QOLCE-16).
Abstract OBJECTIVE: The aim of this study was to assess measurement equivalence in the 16-item short-form Quality of Life in Childhood Epilepsy Questionnaire (QOLCE-16) across age, sex, and time in a sample of children with newly diagnosed epilepsy. METHODS: Data came from 373 children participating in the Health-related Quality of Life in Children with Epilepsy Study (HERQULES), a multicenter prospective cohort study. Measurement equivalence was assessed using multigroup confirmatory factor analysis methods. Comparison groups were stratified by age (4-7 years vs. 8-12 years), sex (male vs. female), and t...
Source: Epilepsy and Behaviour - December 7, 2018 Category: Neurology Authors: Goodwin SW, Ferro MA, Speechley KN Tags: Epilepsy Behav Source Type: research

What information about sudden unexpected death in epilepsy (SUDEP) is available on YouTube?
CONCLUSION: Substantial information is available regarding SUDEP on YouTube; however, the viewer engagement remains limited. Individual user-created videos about SUDEP are the most popular and viewer engaging. Incorporating personal/anecdotal experiences in addition to scientific information in the video content might further improve the viewer engagement. PMID: 30528465 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - December 6, 2018 Category: Neurology Authors: Rayi A, Borad SJ, Kemper SE, Malhotra K Tags: Epilepsy Behav Source Type: research

The 4th International Lafora Epilepsy Workshop: Shifting paradigms, paths to treatment, and hope for patients.
PMID: 30528121 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - December 5, 2018 Category: Neurology Authors: Brewer MK, Grossman TR, McKnight TR, Goldberg YP, Landy H, Gentry MS Tags: Epilepsy Behav Source Type: research

Outcomes and comorbidities of SCN1A-related seizure disorders.
CONCLUSIONS: Severe behavioral problems and walking disabilities are common in patients with Dravet syndrome and should receive specific attention during clinical management. Although the epilepsy course of patients with non-Dravet syndromes is much more favorable, milder comorbidities frequently occur in this group as well. Our results may be of great value for clinical care and informing newly diagnosed patients and their parents about prognosis. PMID: 30527252 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - December 4, 2018 Category: Neurology Authors: de Lange IM, Gunning B, Sonsma ACM, van Gemert L, van Kempen M, Verbeek NE, Sinoo C, Nicolai J, Knoers NVAM, Koeleman BPC, Brilstra EH Tags: Epilepsy Behav Source Type: research

Incidence of epilepsy and associated factors in elderly patients in Germany.
CONCLUSIONS: The incidence of epilepsy was high and increased with age in elderly patients followed in general practices in Germany. Addressing identified risk factors may help reduce the risk of developing epilepsy. PMID: 30529258 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - December 4, 2018 Category: Neurology Authors: Jacob L, Bohlken J, Schmitz B, Kostev K Tags: Epilepsy Behav Source Type: research

Online behavior of people visiting a scientific website on epilepsy.
Abstract We investigated the online behavior of Internet users consulting the website of the Italian Chapter of the International League Against Epilepsy (Lega Italiana Contro l'Epilessia [LICE]). We obtained the visualization statistics of the LICE website using AWStats (https://awstats.sourceforge.io/) and Google Trends (https://trends.google.com/trends/), and compared the statistics of years 2010, 2014, and 2017. The following variables were analyzed: number of unique visitors and visits, visit duration, the day of week and rush hours, most downloaded documents, most viewed pages, keyphrases and keywords used f...
Source: Epilepsy and Behaviour - December 3, 2018 Category: Neurology Authors: Brigo F, Lattanzi S, Kinney MO, Bragazzi NL, Tassi L, Nardone R, Mecarelli O Tags: Epilepsy Behav Source Type: research

Long-term seizure outcome in frontal lobe epilepsy surgery.
CONCLUSION: Surgery is a safe treatment option in drug-resistant FLE with a satisfying long-term outcome. These data highlight the importance of an appropriate selection of potential surgical candidates. PMID: 30522059 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - December 3, 2018 Category: Neurology Authors: Morace R, Casciato S, Quarato PP, Mascia A, D'Aniello A, Grammaldo LG, De Risi M, Di Gennaro G, Esposito V Tags: Epilepsy Behav Source Type: research

A systematic review of sudden unexpected death in epilepsy (SUDEP) in childhood.
CONCLUSIONS: There is currently insufficient evidence to determine the etiology of pediatric SUDEP. Current best practice to prevent pediatric SUDEP is to optimize the management of epilepsy. A national SUDEP registry would provide invaluable high-quality data and insights into modifiable risk factors, genetic predispositions, and novel prevention strategies. PMID: 30522060 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - December 3, 2018 Category: Neurology Authors: Abdel-Mannan O, Taylor H, Donner EJ, Sutcliffe AG Tags: Epilepsy Behav Source Type: research

Cortical excitability affects mood state in patients with idiopathic generalized epilepsies (IGEs).
This study aimed to investigate the influences of cortical excitability and seizure control on mood state in patients with IGEs. Single and paired-pulse transcranial magnetic stimulation (TMS) was applied to 30 patients with IGEs (16 controlled IGEs [cIGEs], 14 with treatment-resistant IGEs [trIGEs]), and 22 healthy controls (HCs) to assess cortical excitability with LICI. The Profile of Mood Sates (POMS) questionnaire was used to assess total mood disturbance (TMD), as well as, six mood domains: Depression, Confusion, Anger, Anxiety, Fatigue, and Vigor. To assess the effects of seizure control (HC vs. cIGEs vs. trIGEs) an...
Source: Epilepsy and Behaviour - December 2, 2018 Category: Neurology Authors: Bolden LB, Griffis JC, Nenert R, Allendorfer JB, Szaflarski JP Tags: Epilepsy Behav Source Type: research

Psychogenic nonepileptic seizures in children and adolescents: An international cross-cultural study.
CONCLUSION: Young patients with PNES across borders and between cultures share more similarities than differences with regard to their demographic and clinical characteristics. PMID: 30517909 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - December 2, 2018 Category: Neurology Authors: Asadi-Pooya AA, AlBaradie R, Sawchuk T, Bahrami Z, Al Amer A, Buchhalter J Tags: Epilepsy Behav Source Type: research

Analysis of EEG networks and their correlation with cognitive impairment in preschool children with epilepsy.
CONCLUSIONS: Cognitive impairment in CWEOE can be detected with sensitivity at 85% (in identifying mild/moderate or severe CI) and specificity of 84%, by network analysis. SIGNIFICANCE: This study outlines a data-driven methodology for identifying candidate biomarkers of CI in CWEOE from network features. Following additional replication, the proposed method and its use of routinely acquired EEG forms an attractive proposition for supporting clinical assessment of CI. PMID: 30513434 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - December 1, 2018 Category: Neurology Authors: Kinney-Lang E, Yoong M, Hunter M, Kamath Tallur K, Shetty J, McLellan A, Fm Chin R, Escudero J Tags: Epilepsy Behav Source Type: research

Negative, but not positive, religious coping strategies are associated with psychological distress, independent of religiosity, in Korean adults with epilepsy.
Abstract PURPOSE: Religion can be important in the everyday lives of persons with epilepsy (PWE). However, there is little research on religion, as it relates to individuals with epilepsy. We determined a relationship between religious coping strategies and psychological distress in Korean adults with epilepsy who had a religious affiliation. METHODS: This cross-sectional study was conducted in outpatient clinics. Religiosity and religious coping strategies were assessed using the Duke University Religion Index (DUREL) and the Brief Religious Coping Scale (B-RCOPE). Psychological distress was measured using t...
Source: Epilepsy and Behaviour - December 1, 2018 Category: Neurology Authors: Lee SA, Choi EJ, Ryu HU Tags: Epilepsy Behav Source Type: research

Factors contributing to excessive daytime sleepiness in Korean adults with epilepsy: A sleep questionnaire-based study.
Abstract OBJECTIVES: We determined factors contributing to excessive daytime sleepiness (EDS) in Korean adults with epilepsy (AWE). METHODS: A total of 147 AWE who had been treated for>1 year were included. Daytime sleepiness was assessed using the Epworth Sleepiness Scale (ESS). Subjective sleep disturbances were assessed with the Sleep Apnea of Sleep Disorder Questionnaire (SA-SDQ) and questionnaires about insomnia and restless legs syndrome (RLS). The Hospital Anxiety and Depression Scale (HADS) was also used. An ESS score>10 was considered indicative of EDS. Multivariate logistic regression analys...
Source: Epilepsy and Behaviour - December 1, 2018 Category: Neurology Authors: Lee SA, No YJ, Jo KD, Kwon JH, Kim JY, Shin DJ Tags: Epilepsy Behav Source Type: research

Level of awareness and attitudes toward epilepsy in Qassim, Saudi Arabia: A cross-sectional study.
CONCLUSION: Insufficient knowledge about epilepsy, which is a very common disorder, has a great and negative impact on people with epilepsy, their families and communities, and the healthcare systems. In our study, we found that good knowledge was associated with being a young adult, male, unmarried, and being a university student. PMID: 30513437 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - December 1, 2018 Category: Neurology Authors: Altowayan R, Aloqaily H, Almutairi A, Almassri R, Alharbi B, Alsallum G, Alhabib R, Alkharaz G, Alateyah A, Alharbi Y, Mohamed EY Tags: Epilepsy Behav Source Type: research

Clinical presentations of onchocerciasis-associated epilepsy (OAE) in Cameroon.
CONCLUSION: People with epilepsy in onchocerciasis-endemic villages in Cameroon present with a wide clinical spectrum including nodding seizures and Nakalanga features. A great majority of participants met the diagnostic criteria for OAE, suggesting that better onchocerciasis control could prevent new cases. Epilepsy management algorithms in these areas must be adjusted to reflect the varied seizure types. PMID: 30513438 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - December 1, 2018 Category: Neurology Authors: Siewe JFN, Ngarka L, Tatah G, Mengnjo MK, Nfor LN, Chokote ES, Boullé C, Nkouonlack C, Dema F, Nkoro GA, Njamnshi WY, Tabah EN, Zoung-Kanyi Bissek AC, Colebunders R, Njamnshi AK Tags: Epilepsy Behav Source Type: research

Lipid and thyroid hormone levels in children with epilepsy treated with levetiracetam or carbamazepine: A prospective observational study.
Abstract Although previous studies have investigated the influence of antiepileptic drugs (AEDs) on lipid profiles and thyroid hormone levels, there is little evidence regarding the effects of levetiracetam (LEV). Therefore, we conducted a prospective longitudinal study to evaluate the effects of LEV and carbamazepine (CBZ) treatment on lipid profile and thyroid hormone levels in patients newly diagnosed with epilepsy. Inclusion criteria were as follows: (a) age between 4 and 15 years, (b) diagnosis of epilepsy with at least two focal seizures within a year, and (c) newly treated with LEV or CBZ monotherapy. Ser...
Source: Epilepsy and Behaviour - November 27, 2018 Category: Neurology Authors: Nishiyama M, Takami Y, Ishida Y, Tomioka K, Tanaka T, Nagase H, Nakagawa T, Tokumoto S, Yamaguchi H, Toyoshima D, Maruyama A, Nozu K, Nishimura N, Iijima K Tags: Epilepsy Behav Source Type: research

Prevalence of psychiatric disorders in Thai patients with epilepsy.
CONCLUSIONS: The prevalence of psychiatric disorders among Thai PWE was higher than that in general population. Screening for psychiatric disorders in PWE is recommended, especially among those who have EEG abnormalities in the temporal lobe. PMID: 30500484 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - November 27, 2018 Category: Neurology Authors: Kuladee S, Prachason T, Srisopit P, Trakulchang D, Boongird A, Wisajan P, Jullagate S Tags: Epilepsy Behav Source Type: research

Changes in self-perception in patients treated with neurostimulating devices.
CONCLUSIONS: Properly designed questionnaires - like the FST-questionnaire as standardized assessment tool - can detect changes in self-perception in patients during neurostimulatory treatment in a wide spectrum of brain stimulation techniques. This may provide a strategy to systematically identify the subgroup of patients liable to experience such problems during treatment already prior to treatment decisions. PMID: 30500485 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - November 27, 2018 Category: Neurology Authors: Eich S, Müller O, Schulze-Bonhage A Tags: Epilepsy Behav Source Type: research

Citing Hippocrates on depression in epilepsy.
Abstract OBJECTIVES: When writing about the bidirectional etiological relationship between depression and epilepsy, neuropsychiatrists often cite Lewis (1934) [Lewis AJ. Melancholia: a historical review. Journal of Mental Science 1934; 80: 1-42] who cited Hippocrates - namely, "melancholics ordinarily become epileptics, and epileptics, melancholics". In this paper, the complicated reference for this citation from Lewis (1934) was critically reappraised. METHODS: The Greek-Latin edition of Hippocratic writings by Ermerins to which Lewis (1934) referred and most volumes of the standard Greek-English e...
Source: Epilepsy and Behaviour - November 27, 2018 Category: Neurology Authors: Hoppe C Tags: Epilepsy Behav Source Type: research

Experiences and needs of parents of young children with active epilepsy: A population-based study.
Abstract The aim of the study was to gain a comprehensive understanding of the experiences and needs of parents of young children with epilepsy from a total population sample. The parents (mothers (n = 38), fathers (n = 9)) of 40/53 (75% of total population) young children (1-7 years; 23 males, 17 females) with 'active' epilepsy (had a seizure in the last year or taking Anti-epileptic drugs (AEDs)) were interviewed either in person or over the telephone using a semistructured interview schedule. The families were resident in the south of the UK. The interviews were audio-recorded, transcribed, and coded ...
Source: Epilepsy and Behaviour - November 27, 2018 Category: Neurology Authors: Jones C, Atkinson P, Memon A, Dabydeen L, Das KB, Cross JH, Gillberg C, Neville BGR, Scott RC, Reilly C Tags: Epilepsy Behav Source Type: research

Electrode placement accuracy in robot-assisted epilepsy surgery: A comparison of different referencing techniques including frame-based CT versus facial laser scan based on CT or MRI.
CONCLUSION: Robot-guided sEEG electrode implantation using CT-frame referencing and CT-laser-based referencing is most accurate and can serve for high precision placement of electrodes. In contrast, 3.0-T MRI-laser-based referencing is less accurate, but saves radiation. Most trajectories can be reached if alternative routes over less vascularized brain areas are used. This article is part of the Special Issue "Individualized Epilepsy Management: Medicines, Surgery and Beyond". PMID: 30497893 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - November 26, 2018 Category: Neurology Authors: Spyrantis A, Cattani A, Woebbecke T, Konczalla J, Strzelczyk A, Rosenow F, Wagner M, Seifert V, Kudernatsch M, Freiman TM Tags: Epilepsy Behav Source Type: research

Experiences of self-conscious emotions in temporal lobe epilepsy.
In conclusion, experiences of SCEs can be dysregulated in patients with TLE. This dysregulation is linked to the patients' clinical and psychological symptoms and quality of life. In this context, SCEs might be a target of interest in the management of epilepsy. PMID: 30476808 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - November 23, 2018 Category: Neurology Authors: Hennion S, Szurhaj W, Skrobala E, Davière J, Tyvaert L, Derambure P, Delbeuck X Tags: Epilepsy Behav Source Type: research

Analysis of tissue Doppler parameters and 24-hour heart rate variations in children with newly diagnosed untreated idiopathic epilepsy in interictal period.
CONCLUSION: We found that patients with untreated newly diagnosed epilepsy have a significant subclinical deterioration of left ventricular functions, and they also showed changes in heart rate variability (HRV) regarding the sympathovagal imbalance in interictal period. These findings can be related with increased cardiac mortality. PMID: 30476809 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - November 23, 2018 Category: Neurology Authors: Tosun O, Karatoprak E Tags: Epilepsy Behav Source Type: research

Coronary vasodilation impairment in pilocarpine model of epilepsy.
Abstract We investigated the coronary arteries reactivity alterations in rats with epilepsy induced by pilocarpine. To do so, male Wistar rats weighing between 250 g and 300 g were used. Status epilepticus (SE) was induced in rats using 385 mg/kg (i.p.) of pilocarpine. After 60 days from the first spontaneous seizure, rats were submitted to heart rate measurements and then, one day after, euthanized, and the heart was dissected and submitted to constant flow Langendorff approaches to evaluate coronary reactivity. Rats with epilepsy showed higher resting heart rate and impairment of coronary vasodilation in...
Source: Epilepsy and Behaviour - November 23, 2018 Category: Neurology Authors: Vitorino PR, Gomes KP, Ghazale PP, da Silva M, Mendes EP, Dos Santos FCA, Pansani AP, de Castro CH, Scorza FA, Colugnati DB Tags: Epilepsy Behav Source Type: research

Determining the cost of first-ever seizures: A narrative review and future directions.
PMID: 30477989 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - November 23, 2018 Category: Neurology Authors: Foster E, Ademi Z, Lawn N, Chen Z, Carney P, Liew D, O'Brien TJ, Kwan P Tags: Epilepsy Behav Source Type: research

Epilepsy surgery for children with severe developmental delay: An ethical double jeopardy.
PMID: 30477990 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - November 23, 2018 Category: Neurology Authors: Yan H, Snead C, Ibrahim GM Tags: Epilepsy Behav Source Type: research

Should adult neurologists play a role in the management of the most common psychiatric comorbidities? Practical considerations.
This article is part of the Special Issue "Obstacles of Treatment of Psychiatric Comorbidities in Epilepsy". PMID: 30471892 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - November 21, 2018 Category: Neurology Authors: Munger Clary HM, Salpekar JA Tags: Epilepsy Behav Source Type: research

Alcohol-related seizures may be associated with more severe depression, alcohol dependence syndrome, and more pronounced alcohol-related problems.
This article is part of the Special Issue "Individualized Epilepsy Management: Medicines, Surgery and Beyond". PMID: 30470458 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - November 20, 2018 Category: Neurology Authors: Gutmane E, Suna N, Tomilova A, Liepina L, Folkmanis V, Karelis G Tags: Epilepsy Behav Source Type: research

The Single Word Auditory Comprehension (SWAC) test: A simple method to identify receptive language areas with electrical stimulation.
CONCLUSION/SIGNIFICANCE: The SWAC test is reliable, simple and fast to implement, and suitable for intraoperating mapping. It could be used as a simple initial test to identify receptive language areas where more complex additional tests can be performed. PMID: 30442560 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - November 13, 2018 Category: Neurology Authors: Alarcón G, Bird Pedersen M, Juárez-Torrejón N, Martín-López D, Ughratdar I, Selway RP, Valentín A Tags: Epilepsy Behav Source Type: research

Interictal psychiatric comorbidities of drug-resistant focal epilepsy: Prevalence and influence of the localization of the epilepsy.
This study aimed to prospectively assess the following: (i) the prevalence of specific and nonspecific interictal psychiatric comorbidities in a population of patients with drug-resistant focal epilepsy and (ii) the influence of epilepsy lateralization and localization on these psychiatric comorbidities. In this prospective monocentric study, we collected demographic data, characteristics of the epilepsy, interictal psychiatric comorbidities, mood, anxiety, and alexithymia dimensions. We used criteria from Diagnostic and Statistical Manual of Mental Disorders IV ( DSM IV) (Mini International Mental Interview (MINI)), diagn...
Source: Epilepsy and Behaviour - November 11, 2018 Category: Neurology Authors: Jansen C, Francomme L, Vignal JP, Jacquot C, Schwan R, Tyvaert L, Maillard L, Hingray C Tags: Epilepsy Behav Source Type: research

Current value of intraoperative electrocorticography (iopECoG).
CONCLUSION: After a period of scepticism, iopECoG seems back in the focus of interest for intraoperative guidance of resecting epileptogenic tissue to raise postoperative favorable seizure outcome. In temporal and extratemporal lesional epilepsies, especially in cases of focal cortical dysplasia, tuberous sclerosis, or cavernous malformations, an excellent correlation between iopECoG-guided resection and postoperative seizure relief was found. PMID: 30420228 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - November 9, 2018 Category: Neurology Authors: Roessler K, Heynold E, Buchfelder M, Stefan H, Hamer HM Tags: Epilepsy Behav Source Type: research

What Saudi teachers know about epilepsy: A cross-sectional study of Tabuk City.
This study was conducted to evaluate awareness, knowledge, and attitudes of teachers toward the disease in Tabuk City in north Saudi Arabia and identify areas in which training and education are required. METHOD: Data were collected from 349 school teachers using a structured 28-item questionnaire. Data were collected between December 2017 and May 2018 in Tabuk City. RESULTS: In general, the study shows a negative trend in knowledge and attitude toward epilepsy. The majority of the participants (84%) have read or heard about epilepsy, and more than half (67%) had witnessed a seizure. Epilepsy was considered conta...
Source: Epilepsy and Behaviour - November 8, 2018 Category: Neurology Authors: Alamri S, Alghamdi A, Al Quait A Tags: Epilepsy Behav Source Type: research

Semiological characteristics of patients with psychogenic nonepileptic seizures: Gender-related differences.
Abstract Psychogenic nonepileptic seizures (PNES) are more prevalent among women, and diagnosis may sometimes be delayed by as much as seven years. Understanding the effect of gender on the presentation of a PNES may assist with diagnosis based on semiological details in the clinical setting. Although video-EEG monitoring (VEM) is the gold standard for diagnosing PNES, determining gender-related seizure semiology through careful history may prevent diagnostic delay while waiting for VEM. The aim of this study was to investigate gender-related differences in the semiology of PNES. Patients, all aged at least 16 y...
Source: Epilepsy and Behaviour - November 8, 2018 Category: Neurology Authors: Korucuk M, Gazioglu S, Yildirim A, Karaguzel EO, Velioglu SK Tags: Epilepsy Behav Source Type: research

Cortical excitability and seizure control influence attention performance in patients with idiopathic generalized epilepsies (IGEs).
Abstract We recently found that higher cortical excitability is associated with poorer attention performance in healthy adults. While patients with idiopathic generalized epilepsies (IGEs), previously termed genetic generalized epilepsies, are known to demonstrate increased cortical excitability and cognitive deficits, a relationship between these variables in IGEs has not been investigated. Therefore, we aimed to characterize the effects of cortical excitability and seizure control on cognitive performance in IGEs. We studied 30 patients with IGEs (16 patients with controlled IGEs (cIGEs) and 14 patients with tre...
Source: Epilepsy and Behaviour - November 8, 2018 Category: Neurology Authors: Bolden LB, Griffis JC, Nenert R, Allendorfer JB, Szaflarski JP Tags: Epilepsy Behav Source Type: research

Revisiting the public awareness, attitudes, and understanding towards epilepsy among Singapore residents.
CONCLUSION: The awareness, attitudes, and understanding towards epilepsy does not seem to show any significant difference when compared with that in 1999. Reluctance to marry and employ a person with epilepsy persists. The awareness about first aid of a patient having a seizure, attitudes towards marrying a person with epilepsy, and the understanding of cause of epilepsy have shown some positive changes over 17 years. PMID: 30415136 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - November 8, 2018 Category: Neurology Authors: Gosavi TD, Wang S, See SJ, Ng J, Lim SH Tags: Epilepsy Behav Source Type: research

Validation of the Chinese version of the Hamilton Rating Scale for Depression in adults with epilepsy.
CONCLUSION: The C-HRSD-17 proved to be a valid and reliable assessment tool, with a cutoff score of 9 for screening of current MDD in Chinese adult PWE. PMID: 30415137 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - November 8, 2018 Category: Neurology Authors: Lin J, Wang X, Dong F, Du Y, Shen J, Ding S, Wang L, Ye M, Wang Y, Xia N, Zheng R, Chen H, Xu H Tags: Epilepsy Behav Source Type: research

Development of the transition-age program (TAP): Review of a pilot psychosocial multidisciplinary transition program in a Level 4 epilepsy center.
Abstract Approximately 50% of patients diagnosed with epilepsy in childhood will need treatment in adulthood. Transition from pediatric to adult epilepsy care is challenging, and an unsuccessful transition can have detrimental effects. Researchers emphasize the importance of addressing possible barriers to transition in a multidisciplinary setting. In this paper, we describe a transition program implemented in a Level 4 epilepsy center in the Midwest. This program involves a psychosocial multidisciplinary team including a pediatric neuropsychologist, pediatric psychologist, and social worker who meet jointly with ...
Source: Epilepsy and Behaviour - November 8, 2018 Category: Neurology Authors: Reger KL, Hughes-Scalise A, O'Connor MA Tags: Epilepsy Behav Source Type: research

Naringin in a combined therapy with phenytoin on pentylenetetrazole-induced kindling in rats.
The objective of the present study was to investigate the effect of the combined treatment of naringin (40 mg/kg and 80 mg/kg) and phenytoin on prevention of seizure attacks, development of kindling, oxidative stress, cognitive impairment, and neurochemicals in the frontal cortex, temporal cortex, and hippocampus, and morphological changes in the hippocampus. Treatment with the high dose of naringin (80 mg/kg) along with phenytoin has shown to offer protection against seizures, development of kindling, and cognition enhancement through Y-maze test and improved % conditioned avoidance response (% CAR) through pole cli...
Source: Epilepsy and Behaviour - November 8, 2018 Category: Neurology Authors: Kola PK, Akula A, Nissankara Rao LS, Danduga RCSR, Mohammad A, Ineedi S Tags: Epilepsy Behav Source Type: research

Making epilepsy a national priority in African countries.
PMID: 30414711 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - November 7, 2018 Category: Neurology Authors: Little A, Secco M, Mugumbate J Tags: Epilepsy Behav Source Type: research

Cesarean section in Australian women with epilepsy.
Abstract The literature suggests that cesarean delivery or birth is carried out more often in pregnant women with epilepsy (WWE) than in pregnant women in the general population. Data were utilized from the Australian Pregnancy Register (APR) for Women on Antiepileptic Medication to investigate this issue in Australia. Over almost two decades, the mean CS rate in 1900 APR women was 39.2%, but was only 29.9% in women in the general population (relative risk (R.R.) = 1.31, 95% confidence interval (C.I.) 1.24, 1.39). Rates for forceps and suction-assisted delivery were similar in the two datasets. The 9.3% excess...
Source: Epilepsy and Behaviour - November 7, 2018 Category: Neurology Authors: Vajda FJE, O'Brien TJ, Graham JE, Hitchcock AA, Kuhn RJP, Lander CM, Eadie MJ Tags: Epilepsy Behav Source Type: research

Parenting stress and perceived stigma in mothers of young children with epilepsy: A case-control study.
Abstract The aim was to provide data on parenting stress and perceived stigma in mothers (n = 47) of young children with epilepsy, and to compare findings with those of mothers (n = 48) of developmental, age- and gender-matched children with nonepilepsy-related neurodisability (neurological and/or neurodevelopmental concerns). The mothers of young children (1-7 years) with epilepsy and mothers of children with neurodisability in a defined geographical area of the UK, completed the Parenting Stress Index-4th Edition (PSI-4) and a measure of perceived stigma. Factors associated with parenting stress and st...
Source: Epilepsy and Behaviour - November 6, 2018 Category: Neurology Authors: Reilly C, Atkinson P, Memon A, Jones C, Dabydeen L, Das KB, Cross JH, Neville BGR, Gillberg C, Scott RC Tags: Epilepsy Behav Source Type: research

Predicting drug-resistant epilepsy - A machine learning approach based on administrative claims data.
Abstract Patients with drug-resistant epilepsy (DRE) are at high risk of morbidity and mortality, yet their referral to specialist care is frequently delayed. The ability to identify patients at high risk of DRE at the time of treatment initiation, and to subsequently steer their treatment pathway toward more personalized interventions, has high clinical utility. Here, we aim to demonstrate the feasibility of developing algorithms for predicting DRE using machine learning methods. Longitudinal, intersected data sourced from US pharmacy, medical, and adjudicated hospital claims from 1,376,756 patients from 2006 to ...
Source: Epilepsy and Behaviour - November 6, 2018 Category: Neurology Authors: An S, Malhotra K, Dilley C, Han-Burgess E, Valdez JN, Robertson J, Clark C, Westover MB, Sun J Tags: Epilepsy Behav Source Type: research

Cancer frequency detected by positron emission tomography-computed tomography in limbic encephalitis.
Abstract OBJECTIVE: Paraneoplastic limbic encephalitis (LE) occurs frequently with considerable variability according to literature reports. We thus determined the cancer frequency in mixed LE subtypes sharing the diagnosis of temporal lobe epilepsy (TLE). METHODS: All patients underwent magnetic resonance imaging (MRI) of the brain, electroencephalography (EEG) recordings, neuropsychological testing, immunohistochemistry, and clinical examination together with whole body 2-fluor-2-desoxy-d-glucose (FDG)-positron emission tomography (PET)/computed tomography (CT) to detect cancer in this observatory study. ...
Source: Epilepsy and Behaviour - November 5, 2018 Category: Neurology Authors: Hansen N, Widman G, Stuff S, Becker AJ, Witt JA, Ahmadzadehfar H, Helmstaedter C, Elger CE Tags: Epilepsy Behav Source Type: research