Invasive EEG-electrodes in presurgical evaluation of epilepsies: Systematic analysis of implantation-, video-EEG-monitoring- and explantation-related complications, and review of literature.
CONCLUSION: Overall, sEEG is a safe and well-tolerated procedure. Systematic imaging after implantation and explantation helps to identify clinically silent complications of sEEG. In the literature, complication rates of up to 4.4% in sEEG and in 49.9% of subdural EEG are reported; however, systematic imaging after explantation was not performed throughout the studies, which may have led to underreporting of associated complications. PMID: 29907526 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - June 13, 2018 Category: Neurology Authors: Willems LM, Reif PS, Spyrantis A, Cattani A, Freiman TM, Seifert V, Wagner M, You SJ, Schubert-Bast S, Bauer S, Klein KM, Rosenow F, Strzelczyk A Tags: Epilepsy Behav Source Type: research

Assessing depression severity with a self-rated vs. rater-administered instrument in patients with epilepsy.
Abstract RATIONALE: Up to 30-50% of individuals with epilepsy have depressive symptoms, which often complicate seizure management and reduce overall quality of life. To identify and manage depressive symptoms appropriately, clinicians need standardized instruments that can accurately identify and monitor those with clinically significant depression. The self-reported 9-item Patient Health Questionnaire (PHQ-9) has been used relatively widely to screen and monitor depression in epilepsy. The rater-administered Montgomery-Asberg Depression Rating Scale (MADRS) is a rater-administered instrument widely used in depres...
Source: Epilepsy and Behaviour - June 13, 2018 Category: Neurology Authors: Jamal-Omidi S, Collins C, Fulchiero E, Liu H, Colon-Zimmermann K, Fuentes-Casiano E, Tatsuoka C, Cassidy KA, Lhatoo S, Sajatovic M Tags: Epilepsy Behav Source Type: research

Knowledge and attitudes towards epilepsy among nonmedical health workers in rural Bolivia: Results after a long-term activity in the Chaco region.
CONCLUSION: Our study confirms the usefulness of continuous educational campaigns, especially directed to nonspecialist healthcare providers of rural communities of LMIC, as they may be the only persons responsible for providing healthcare to PWE in that setting. Moreover, the importance of the baseline assessment of KAP was highlighted in order to adapt the educational campaigns to the baseline level of knowledge found. PMID: 29908385 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - June 13, 2018 Category: Neurology Authors: Giuliano L, Cicero CE, Padilla S, Camargo M, Sofia V, Zappia M, Bartoloni A, Crespo Gómez EB, Nicoletti A Tags: Epilepsy Behav Source Type: research

Anxiety is common and independently associated with clinical features of epilepsy.
The objective of this study was to assess for independent association of anxiety symptoms with epilepsy localization and other epilepsy-related and demographic factors in a large tertiary care adult epilepsy population. METHODS: Among 540 adults, anxiety was measured by the Symptom Checklist 90-R (SCL-90R) anxiety subscale, and detailed demographics, epilepsy localization, and depression scores (SCL-90R) were collected. High anxiety was defined by SCL-90R anxiety T-score ≥ 60. Stepwise multiple logistic regression was carried out to assess for independent association of high anxiety scores with demographic and ...
Source: Epilepsy and Behaviour - June 13, 2018 Category: Neurology Authors: Munger Clary HM, Snively BM, Hamberger MJ Tags: Epilepsy Behav Source Type: research

Epilepsy mortality trends in Cuba compared with England and Wales: 1987-2010.
We examined national epilepsy mortality data from Cuba and contrasted them with comparable data from England and Wales. National epilepsy mortality data for Cuba between the years 1987 and 2010 were obtained from the Medical Records and Health Statistics Bureau of the Cuban Public Health Ministry (www.sld.cu/sitios/dne/) with the corresponding mortality data from England and Wales obtained from the UK Office of National Statistics (ONS, www.ons.gov.uk). Indirect standardization with calculation of a standardized mortality ratio (SMR) was used to compare trends. The overall trend was of a slight decrease in mortality rates ...
Source: Epilepsy and Behaviour - June 13, 2018 Category: Neurology Authors: Suárez-Medina R, Morales-Chacón LM, Venero-Fernández SJ, Liu C, Fogarty AW, Neligan A Tags: Epilepsy Behav Source Type: research

Ictal signs in tuberous sclerosis complex: Clinical and video-EEG features in a large series of recorded seizures.
Abstract Epilepsy is the most common neurological symptom in tuberous sclerosis complex (TSC), occurring in 72-85% of affected individuals. Despite the large number of patients reported, their electroclinical phenotype has been rarely described. We analyzed seizure semiology through ictal video-electroencephalography (V-EEG) recordings in a large series of patients. In this multicenter study, we reviewed V-EEGs of 51 patients: ictal recordings were analyzed in correlation with their clinical variables. The median age of epilepsy onset was six months (one day-16 years), with onset in the first year of life in 71%...
Source: Epilepsy and Behaviour - June 12, 2018 Category: Neurology Authors: Savini MN, Mingarelli A, Vignoli A, La Briola F, Chiesa V, Peron A, Mai R, Tassi L, Mastrangelo M, Zambrelli E, Turner K, Canevini MP Tags: Epilepsy Behav Source Type: research

Epilepsy misconceptions and stigma reduction interventions in sub-Saharan Africa, a systematic review.
CONCLUSIONS: Epilepsy misconceptions, stigmatizing cultural beliefs, and perceptions were widely prevalent in SSA, and there are a few studies targeting epilepsy stigma. Existing stigma-reduction educational approaches may be impractical for general population implementation. Scalable approaches to reduce stigma are urgently needed within SSA. PMID: 29906697 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - June 12, 2018 Category: Neurology Authors: Kaddumukasa M, Kaddumukasa MN, Buwembo W, Munabi IG, Blixen C, Lhatoo S, Sewankambo N, Katabira E, Sajatovic M Tags: Epilepsy Behav Source Type: research

Levetiracetam efficacy on frontal lobe dysfunctions and anger rumination in patients with epilepsy.
This study compared the frontal lobe functioning and anger rumination between patients with epilepsy and healthy individuals. The second objective was to examine the efficacy of levetiracetam therapy on frontal lobe dysfunctions and anger rumination in patients with epilepsy. Participants (50 patients with epilepsy and 50 healthy individuals) completed the Frontal Assessment Battery (FAB) and Anger Rumination Scale (ARS). The patients had two testing sessions: pre- and post-levetiracetam therapies. The results showed that patients with epilepsy had frontal lobe dysfunctions in contrast with healthy individuals. Patients wi...
Source: Epilepsy and Behaviour - June 12, 2018 Category: Neurology Authors: Gul A, Mehreen S Tags: Epilepsy Behav Source Type: research

Causes of mortality in early infantile epileptic encephalopathy: A systematic review.
DISCUSSION: The results show EIEE as a severe disease associated with a premature mortality, evidenced by a very young age at death. Increasing interest in the detection of new molecular bases of EIEE is leading us to a better understanding of this severe disease, but well-reported data are lacking to clarify EIEE-related causes of death. PMID: 29906699 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - June 12, 2018 Category: Neurology Authors: Radaelli G, de Souza Santos F, Borelli WV, Pisani L, Nunes ML, Scorza FA, da Costa JC Tags: Epilepsy Behav Source Type: research

Patient characteristics and treatment patterns in patients with newly diagnosed epilepsy: A US database analysis.
The objective of this study was to determine patient characteristics and antiepileptic drug (AED) treatment patterns in patients with newly diagnosed epilepsy in a United States (US) population followed for ≥180 days. METHODS: In this retrospective cohort study, Commercial, Supplemental Medicare, and Medicaid insurance claims from US-based Truven Health MarketScan® claims database were analyzed for incident epilepsy cases (index date: January 2010-June 2013; prior baseline of 2 years [1 year for ages 1 to
Source: Epilepsy and Behaviour - June 12, 2018 Category: Neurology Authors: Faught E, Helmers S, Thurman D, Kim H, Kalilani L Tags: Epilepsy Behav Source Type: research

Cognition, mood and quality-of-life outcomes among low literacy adults living with epilepsy in rural Kenya: A preliminary study.
Abstract Epilepsy is frequently associated with neurocognitive impairments, mental health, and psychosocial problems but these are rarely documented in low- and middle-income countries. The aim of this study was to examine the neurocognitive outcomes, depressive symptoms, and psychosocial adjustments of people with epilepsy (PWE) in Kilifi, Kenya. We evaluated the impact of these outcomes on health-related quality of life. Self-report, interviewer-administered measures of depression (Major Depression Inventory) and quality of life (RAND SF-36) were administered to 63 PWE and 83 community controls. Neurocognitive f...
Source: Epilepsy and Behaviour - June 12, 2018 Category: Neurology Authors: Mwangala PN, Kariuki SM, Nyongesa MK, Mwangi P, Chongwo E, Newton CR, Abubakar A Tags: Epilepsy Behav Source Type: research

Quality of life among women with epilepsy during their reproductive years.
Abstract PURPOSE: The purpose of this study was to assess the health-related quality of life (HRQoL) of women with epilepsy during their reproductive years. METHOD: A cross-sectional study comparing two groups, one with and another without epilepsy, was conducted. Semistructure questionnaires regarding socioeconomic, demographic, and clinical profiles were used. The HRQoL was measured using the Quality of Life in Epilepsy Inventory (QOLIE-31), for comparison within the group with epilepsy, and World Health Organization of Quality of Life (WHOQOL)-bref, for comparison between the groups with and without epilep...
Source: Epilepsy and Behaviour - June 8, 2018 Category: Neurology Authors: Santos AMC, Castro-Lima H, Matos MAA, Brito MB Tags: Epilepsy Behav Source Type: research

Using electrocorticogram baseline seizure frequency to assess the efficacy of responsive neurostimulation.
CONCLUSION: Chronic ECoG may provide a more accurate estimate of seizure frequency and provide additional insight into the true efficacy of the RNS system. PMID: 29890343 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - June 8, 2018 Category: Neurology Authors: Young MG, Vadera S, Lin JJ, Mnatsakanyan L Tags: Epilepsy Behav Source Type: research

Lessons from the past: Hyperthermia in status epilepticus in the first descriptions by D ésiré-Magloire Bourneville (1840-1909).
Lessons from the past: Hyperthermia in status epilepticus in the first descriptions by Désiré-Magloire Bourneville (1840-1909). Epilepsy Behav. 2018 Jun 07;: Authors: Brigo F, Trinka E PMID: 29887402 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - June 7, 2018 Category: Neurology Authors: Brigo F, Trinka E Tags: Epilepsy Behav Source Type: research

Affiliate stigma and caregiver burden in intractable epilepsy.
This study examined the relationship between affiliate stigma and the levels of burden experienced by caregivers, as well as how these levels may vary between those caring for children and adults. This cross-sectional approach used a self-administered survey offered to caregivers of family members with confirmed diagnoses of intractable epilepsy. We measured burden with the 30-item Carer's Assessment of Difficulties Index (CADI) and affiliate stigma with a six-item scale examining caregivers' perceptions of stigma directed toward themselves and their family members with epilepsy. Four nested ordinary-least-squares regressi...
Source: Epilepsy and Behaviour - June 7, 2018 Category: Neurology Authors: Hansen B, Szaflarski M, Bebin EM, Szaflarski JP Tags: Epilepsy Behav Source Type: research

Correlates of epilepsy self-management in MEW Network participants: From the Centers for Disease Control and Prevention Managing Epilepsy Well Network.
Abstract While self-management (S-M) skills of people living with epilepsy (PWE) are increasingly recognized as important for daily functioning and quality of life, there is limited information on overall skill levels, specific areas needing improvement, or associated correlates. The purpose of this study was to provide evidence on the S-M skills of PWE and identify the demographic and clinical correlates that could be used in targeting interventions. Data were derived from the Managing Epilepsy Well (MEW) research network database containing epilepsy S-M data on 436 PWE participating in five studies conducted rec...
Source: Epilepsy and Behaviour - May 28, 2018 Category: Neurology Authors: Begley C, Shegog R, Liu H, Tatsuoka C, Spruill TM, Friedman D, Fraser RT, Johnson EK, Bamps YA, Sajatovic M Tags: Epilepsy Behav Source Type: research

Validation of the Polish version of the Hospital Anxiety and Depression Scale for anxiety disorders in patients with epilepsy.
CONCLUSIONS: The HADS-A proved to be a valid and reliable psychometric instrument in terms of screening for anxiety disorders in our sample of PWEs. In the epilepsy setting, the HADS-A maintains adequate sensitivity, acceptable specificity, and high NPV but low PPV for diagnosing anxiety disorders with an optimum cutoff score ≥10. PMID: 29803946 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - May 24, 2018 Category: Neurology Authors: Wiglusz MS, Landowski J, Cubała WJ Tags: Epilepsy Behav Source Type: research

Bitemporal seizure spread and its effect on autonomic dysfunction.
CONCLUSION: This study shows that bitemporal seizure activity significantly increases heart rate and decreases HRV, indicating increased autonomic imbalance with a shift towards sympathetic predominance, and this may increase the risk of SUDEP. PMID: 29803947 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - May 24, 2018 Category: Neurology Authors: Page T, Rugg-Gunn FJ Tags: Epilepsy Behav Source Type: research

Language mapping using electrocorticography versus stereoelectroencephalography: A case series.
We report a case series of fifteen patients that underwent language mapping with either ECOG (5), SEEG (9), or both (1). Six patients in the SEEG group underwent resection or ablation with only mapping via SEEG. No patients in the SEEG group that underwent resective or ablative surgery experienced persistent language deficits. These results suggest that language mapping with SEEG may be considered as a clinically useful alternative to language mapping with ECOG. PMID: 29803145 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - May 23, 2018 Category: Neurology Authors: Young JJ, Coulehan K, Fields MC, Yoo JY, Marcuse LV, Jette N, Panov F, Ghatan S, Bender HA Tags: Epilepsy Behav Source Type: research

"Seizures have become a means of somehow learning things about myself" - A qualitative study of the development of self-efficacy and mastery during a psychotherapeutic intervention for people with epilepsy.
CONCLUSION: The qualitative differences observed before and after a psychotherapeutic intervention for individuals with epilepsy increase our understanding of the complex process of psychotherapy-associated change involving self-efficacy and mastery and highlight the contribution that qualitative research approaches can make. PMID: 29803945 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - May 23, 2018 Category: Neurology Authors: Michaelis R, Niedermann C, Reuber M, Kuthe M, Berger B Tags: Epilepsy Behav Source Type: research

Cumulative effect of transcranial direct current stimulation in patients with partial refractory epilepsy and its association with phase lag index-A preliminary study.
Abstract There is an urgent need for alternative treatments for refractory epilepsy. We investigated the effect of two courses of cathodal transcranial direct current stimulation (tDCS) in nine patients with partial refractory epilepsy. A two-course treatment (1 month per course, with six sessions of stimulation per course within the first 2 weeks by 2-mA cathodal tDCS for 20 min) was administered to each patient. After the first course of tDCS, the average seizure frequency had decreased by 37.8 ± 21.9% compared with baseline (p = 0.001). After the second course, the average seizure frequency...
Source: Epilepsy and Behaviour - May 22, 2018 Category: Neurology Authors: Lin LC, Ouyang CS, Chiang CT, Yang RC, Wu RC, Wu HC Tags: Epilepsy Behav Source Type: research

IBE Commission on e-Solutions, Game Plan.
gen H PMID: 29802065 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - May 22, 2018 Category: Neurology Authors: Kissani N, Brodie M, Modeste Lengané YT, Eliashiv D, Ozkara C, Patterson V, Shears G, Aziz H, Riphagen H Tags: Epilepsy Behav Source Type: research

Assessing comfort in the epilepsy monitoring unit: Development of an instrument.
CONCLUSIONS: Enhancing comfort is a fundamental nursing goal in demanding situations. Therefore, the contribution of nurses to the quality of individualized patient care is a substantial one. The EMUCQ is a valuable tool to support the assessment of comfort levels. The ISPOR guidelines proved to be useful to ensure high quality of the translated instrument. Using cognitive interviews enhanced the understandability of items and supported modification of the GCQ. At present, S-CVI/ave value of the EMUCQ is acceptable. Further testing is necessary. PMID: 29793841 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - May 21, 2018 Category: Neurology Authors: Egger-Rainer A, Lorenzl S, Trinka E Tags: Epilepsy Behav Source Type: research

Cognitive functions, electroencephalographic and diffusion tensor imaging changes in children with active idiopathic epilepsy.
CONCLUSION: Children with epilepsy and normal cognitive functions differ in white matter integrity, measured using DTI, compared with children with cognitive dysfunction. These changes have important cognitive consequences. PMID: 29800799 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - May 21, 2018 Category: Neurology Authors: A Yassine I, M Eldeeb W, A Gad K, A Ashour Y, A Yassine I, O Hosny A Tags: Epilepsy Behav Source Type: research

Voxel-based automated detection of focal cortical dysplasia lesions using diffusion tensor imaging and T2-weighted MRI data.
Abstract The aim of this study was to automatically detect focal cortical dysplasia (FCD) lesions in patients with extratemporal lobe epilepsy by relying on diffusion tensor imaging (DTI) and T2-weighted magnetic resonance imaging (MRI) data. We implemented an automated classifier using voxel-based multimodal features to identify gray and white matter abnormalities of FCD in patient cohorts. In addition to the commonly used T2-weighted image intensity feature, DTI-based features were also utilized. A Gaussian processes for machine learning (GPML) classifier was tested on 12 patients with FCD (8 with histologically...
Source: Epilepsy and Behaviour - May 21, 2018 Category: Neurology Authors: Wang Y, Zhou Y, Wang H, Cui J, Nguchu BA, Zhang X, Qiu B, Wang X, Zhu M Tags: Epilepsy Behav Source Type: research

Seizure imitators monitored using video-EEG in children with intellectual disabilities.
Abstract Diagnosis of seizure imitators in children is often challenging, and individuals with intellectual disability (ID) could be at additional risk of seizure imitator misdiagnosis. We aimed to elucidate distinct features of clinical semiology among children of different intellectual levels, which may help in distinguishing seizure imitators from epilepsy in such individuals. We retrospectively compared semiological features of seizure imitators in children with and without ID captured using video-electroencephalography (video-EEG). Seizure imitators were classified based on the definition of the International...
Source: Epilepsy and Behaviour - May 20, 2018 Category: Neurology Authors: Ueda R, Shimizu-Motohashi Y, Sugai K, Takeshita E, Ishiyama A, Saito T, Komaki H, Nakagawa E, Sasaki M Tags: Epilepsy Behav Source Type: research

Predictors of long-term mortality in status epilepticus.
CONCLUSION: Long-term mortality in patients with SE had both positive and negative predictors in the national database. PMID: 29778845 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - May 17, 2018 Category: Neurology Authors: Tiamkao S, Saybungkla P, Sirikarn P, Sawanyawisuth K, Integrated Epilepsy Research Group Tags: Epilepsy Behav Source Type: research

Efficacy and tolerability of treatment with lacosamide: Postmarketing experience from the Middle East region.
CONCLUSIONS: Our data show similar efficacy and tolerability to those reported from Western countries. Our results also substantiate the early introduction of LCM and support the dose reduction of baseline AED especially that of sodium channel blockers to minimize adverse events. PMID: 29778846 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - May 17, 2018 Category: Neurology Authors: Arabi M, Alsaadi T, Nasreddine W, Al-Hashel J, Dirani M, Beydoun A Tags: Epilepsy Behav Source Type: research

Long-term outcome in children with neonatal seizures: A tertiary center experience in cohort of 168 patients.
CONCLUSIONS: Long-term outcome in children with NS could be favorable in most patients, and it appears to be related to specific early clinical and paraclinical variables. Newborns with an abnormal background EEG activity, with seizures resistant to antiepileptic drugs and/or low Apgar score are at a higher risk of a poor outcome. Females are at a much higher risk of lethal outcome than males. PMID: 29775848 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - May 15, 2018 Category: Neurology Authors: Tadic BV, Kravljanac R, Sretenovic V, Vukomanovic V Tags: Epilepsy Behav Source Type: research

Epilepsy South Africa celebrates its 50th anniversary.
PMID: 29764729 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - May 12, 2018 Category: Neurology Authors: Clarke M Tags: Epilepsy Behav Source Type: research

Yield of EEG monitoring in children with developmental disabilities is high.
CONCLUSION: Considering the high diagnostic yield of an awake and asleep EEG monitoring, as it was observed in the current study, this test on a screening basis can be reasonably justified in all children with developmental disabilities. PMID: 29758444 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - May 11, 2018 Category: Neurology Authors: Asadi-Pooya AA Tags: Epilepsy Behav Source Type: research

Intravenous lacosamide (LCM) in status epilepticus (SE): Weight-adjusted dose and efficacy.
CONCLUSIONS: In adults with benzodiazepine-resistant SE, the response rate to LCM was higher, with weight-adjusted doses above 5.3 mg/kg. PMID: 29758445 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - May 11, 2018 Category: Neurology Authors: Santamarina E, González-Cuevas M, Toledo M, Jiménez M, Becerra JL, Quílez A, Suller A, Mauri JA, Fernández Á, Marinas A, Quintana M, Puig XS Tags: Epilepsy Behav Source Type: research

Improving staff response to seizures on the epilepsy monitoring unit with online EEG seizure detection algorithms.
CONCLUSIONS: EEG-video seizure detection algorithms may improve reaction to seizures by improving the total number of seizures detected and the speed of detection. The false positive rate is feasible for use in a clinical situation. Implementation of these algorithms might result in faster diagnostic testing and better observation during seizures. PMID: 29758446 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - May 11, 2018 Category: Neurology Authors: Rommens N, Geertsema E, Jansen Holleboom L, Cox F, Visser G Tags: Epilepsy Behav Source Type: research

Amantadine: A new treatment for refractory electrical status epilepticus in sleep.
CONCLUSIONS: This study suggests that amantadine may be effective in the treatment of ESES-associated syndromes but warrants replication in a more rigorous study. PMID: 29754107 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - May 10, 2018 Category: Neurology Authors: Wilson RB, Eliyan Y, Sankar R, Hussain SA Tags: Epilepsy Behav Source Type: research

Knowledge of women issues and epilepsy among doctors in Sudan.
CONCLUSIONS: In this small cross-sectional study, Sudanese doctors' knowledge was not satisfactory regarding the majority of questions on KOWIE II. Further education and training are indicated to decrease this knowledge gap and to improve care of WWE. PMID: 29754108 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - May 10, 2018 Category: Neurology Authors: Elnaeim AK, Elnaeim MK, Babiker IBA Tags: Epilepsy Behav Source Type: research

Improving effect of mild foot electrical stimulation on pentylenetetrazole-induced impairment of learning and memory.
Abstract Epilepsy is a common neurological disorder that affects learning and memory. Recently it has been shown that mild foot electrical stimulation (MFES) can increase learning and memory in normal rats. Pentylenetetrazole (PTZ) kindling is a model of human epilepsy. As with human epilepsy, PTZ kindling impairs learning and memory in rats. The purpose of this study was to investigate the effect MFES on kindling-induced learning and memory deficits in rats. Forty-nine male Wistar rats weighting 200 to 250 g were divided into the following seven groups: PTZ only, phenytoin only, MFES only, PTZ plus phenytoin, P...
Source: Epilepsy and Behaviour - May 10, 2018 Category: Neurology Authors: Abasi-Moghadam M, Ghasemi-Dehno A, Sadegh M, Palizvan MR Tags: Epilepsy Behav Source Type: research

Ghanaian traditional and faith healers' explanatory models for epilepsy.
Abstract Epilepsy is the most common neurological condition in sub-Saharan Africa. A significant number of people with epilepsy in low- and middle-income countries do not receive formal biomedical care. They utilize the services of various traditional and alternative medicine practitioners. However, there is relatively little information about the beliefs and methods of alternative healthcare providers about epilepsy in many African countries. Using explanatory models of illness framework, we interviewed thirty-six traditional and faith healers in Ghana on their beliefs and perceptions about epilepsy, as well as h...
Source: Epilepsy and Behaviour - May 10, 2018 Category: Neurology Authors: Kpobi L, Swartz L, Keikelame MJ Tags: Epilepsy Behav Source Type: research

Noncompliance of patients with driving restrictions due to uncontrolled epilepsy.
k A Abstract Epilepsies are a common and chronic neurological disorder characterized by sustained risk of recurrent seizures. Because of paroxysmal and often unpredictable occurrence of seizures, patients with uncontrolled epilepsy are subject to disease-specific restrictions in daily life, such as their career choice or specific work limitations. According to German law and many other European and international guidelines, driving is strictly prohibited in patients with uncontrolled epilepsy so as to increase active and passive safety in public road traffic. Nevertheless, a significant percentage of patients prob...
Source: Epilepsy and Behaviour - May 9, 2018 Category: Neurology Authors: Willems LM, Reif PS, Knake S, Hamer HM, Willems C, Krämer G, Rosenow F, Strzelczyk A Tags: Epilepsy Behav Source Type: research

Risk assessment of in-hospital mortality of patients with epilepsy: A large cohort study.
CONCLUSION: The in-hospital mortality of PWE increased remarkably with age, and this parameter was predominant in male patients. Central nervous system infection, renal disease, traumatic brain and head injuries, anoxic brain injury, metastatic cancer, pulmonary circulation disorders, encephalopathy, solid tumor without metastasis, cardiac arrhythmias, and diabetes without complication were the most important comorbidities associated with in-hospital death. PMID: 29753293 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - May 9, 2018 Category: Neurology Authors: Si Y, Xiao X, Xiang S, Liu J, Mo Q, Sun H Tags: Epilepsy Behav Source Type: research

Prescription trends and psychiatric symptoms following first receipt of one of seven common antiepileptic drugs in general practice.
This study provides evidence that carbamazepine and lamotrigine are associated with lower hazards for psychiatric symptoms following a diagnosis of epilepsy. These estimates can be used in clinical settings, and the precision should improve with more contemporary data that include larger proportions of newer generation AEDs. PMID: 29753294 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - May 9, 2018 Category: Neurology Authors: Josephson CB, Engbers JDT, Jette N, Patten SB, Sajobi TT, Marshall D, Lowerison M, Wiebe S Tags: Epilepsy Behav Source Type: research

Major depressive disorder in epilepsy clinics: A meta-analysis.
Abstract BACKGROUND AND PURPOSE: Although depression is a frequent psychiatric comorbidity in people with epilepsy (PWE), its prevalence has been underestimated. Comorbid depression has negative impacts on treatment outcomes and quality of life (QOL). It also causes various problems in PWE, such as fatigue, irritability, and suicidality. This meta-analysis was performed to estimate the frequency of major depression disorder (MDD) in clinics managing PWE. METHODS: We searched MEDLINE, EMBASE, Cochrane Library, Web of Science, and SCOPUS to identify studies. Hospital-based studies and original research presenti...
Source: Epilepsy and Behaviour - May 9, 2018 Category: Neurology Authors: Kim M, Kim YS, Kim DH, Yang TW, Kwon OY Tags: Epilepsy Behav Source Type: research

Mortality-specific comorbidity among inpatients with epilepsy: A preliminary cross-sectional study in West China.
Abstract PURPOSE: The purpose of this study was to investigate the current condition of mortality-specific comorbidity among hospitalized patients with epilepsy (PWE). METHODS: The discharge abstract records of PWE from over 730,000 admissions were extracted from the hospital medical database. Fourteen mortality-related comorbidities from an epilepsy-specific index (ESI) were selected for the present assessment. The hospital-based prevalence of these comorbidities was estimated. The distributions of PWE with an ESI-based prognostic score were calculated. RESULTS: A cohort of 11,422 PWE (male 58.5%) was i...
Source: Epilepsy and Behaviour - May 9, 2018 Category: Neurology Authors: Si Y, Xiao X, Sun H Tags: Epilepsy Behav Source Type: research

Optimizing parents' performance in anticonvulsant rescue medication administration.
Abstract OBJECTIVE: Parents of children with epilepsy are at risk of committing high-risk handling errors with a high potential to harm the patient when administering anticonvulsant rescue medication. We developed a training concept addressing identified high-risk handling errors and investigated its effects on parents' skills. STUDY DESIGN: In a controlled prospective intervention study, parents of children with epilepsy were asked to demonstrate their administration of rescue medication by using dummy dolls. A clinical pharmacist monitored rectal or buccal administration and addressed errors in the interven...
Source: Epilepsy and Behaviour - May 7, 2018 Category: Neurology Authors: Schumacher PM, Kaune A, Merkenschlager A, Bernhard MK, Kiess W, Neininger MP, Bertsche A, Bertsche T Tags: Epilepsy Behav Source Type: research

Predictive values and specificity of electroencephalographic findings in autoimmune encephalitis diagnosis.
Abstract OBJECTIVE: Early diagnosis of autoimmune encephalitis (AE) to not delay treatment is challenging but needed in practice. Most previous evidences of electroencephalographic (EEG) findings in AE were derived from descriptive studies. Given paucity of evidence of specific EEG findings to help with early diagnosis of AE, this study aimed to ascertain specific EEG findings and assess their predictive values in diagnosis of AE. METHODS: We included all cases with AE in our institution from January 2013 to June 2017. Cases were matched with controls by age and level of consciousness (1:2 ratio). Potential c...
Source: Epilepsy and Behaviour - May 5, 2018 Category: Neurology Authors: Limotai C, Denlertchaikul C, Saraya AW, Jirasakuldej S Tags: Epilepsy Behav Source Type: research

Late-onset anti-N-methyl-d-aspartate receptor encephalitis in China.
CONCLUSION: Delayed admission and diagnosis are more common in older adults than in younger adults. A comprehensive consideration of all symptoms and early screening of NMDAR Ab, especially in cerebrospinal fluid, is necessary and beneficial to differential diagnosis. PMID: 29734104 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - May 4, 2018 Category: Neurology Authors: Zhang L, Liu X, Jiang XY, Wang YH, Li JM, Zhou D Tags: Epilepsy Behav Source Type: research

The effects of ethosuximide on aversive instrumental learning in adult rats.
Abstract Antiepileptic medications are the frontline treatment for seizure conditions but are not without cognitive side effects. Previously, our laboratory reported learning deficits in phenytoin-, carbamazepine-, valproic acid-, and felbamate-treated rats. In this experiment, the effects found in ethosuximide (ETH)-treated rats have been compared with those in water-treated controls (controls) using the same instrumental training tasks. Rats treated with ETH did not display any performance deficits in any of the conditions tested relative to controls. These animals showed more rapid acquisition of the avoidance ...
Source: Epilepsy and Behaviour - May 3, 2018 Category: Neurology Authors: Orczyk JJ, Garraghty PE Tags: Epilepsy Behav Source Type: research

Changes in antiepileptic drug-prescribing patterns in pregnant women with epilepsy.
Abstract OBJECTIVE: We analyzed current prescribing patterns for antiepileptic drugs (AEDs) in pregnant women with epilepsy (PWWE) at 20 USA tertiary epilepsy centers. METHODS: The Maternal Outcomes and Neurodevelopmental Effects of Antiepileptic Drugs (MONEAD) study is an NIH-funded, prospective, observational, multicenter investigation of pregnancy outcomes for both mother and child, which enrolled women from December 2012 to January 2016. Inclusion criteria for PWWE included ages 14-45 years and up to 20 weeks gestational age. Exclusion criteria included history of psychogenic nonepileptic spells, expe...
Source: Epilepsy and Behaviour - May 3, 2018 Category: Neurology Authors: Meador KJ, Pennell PB, May RC, Gerard E, Kalayjian L, Velez-Ruiz N, Penovich P, Cavitt J, French J, Hwang S, Pack AM, Sam M, Moore E, Ippolito DM, MONEAD Investigator Group Tags: Epilepsy Behav Source Type: research

Language skills in children with benign childhood epilepsy with centrotemporal spikes: A systematic review.
Abstract Benign childhood epilepsy with centrotemporal spikes (BECTS) is the epileptic syndrome that most affects preschool and school-age children. Despite being usually considered a benign condition, several studies have shown that this epileptic syndrome is responsible for cognitive morbidities in children, namely at the level of attention and memory, as well as language. However, language disorders are still superficially addressed by the literature. This review aimed to compile and synthesize recent literature in this area. This systematic bibliographic research comprises studies published between 2005 and 20...
Source: Epilepsy and Behaviour - May 3, 2018 Category: Neurology Authors: Teixeira J, Santos ME Tags: Epilepsy Behav Source Type: research

Computer-based monitoring and evaluation of epilepsy-related health variables and their impact on treatment decision.
CONCLUSION: The use of ePROs was feasible and well accepted in the clinical setting. Treatment-associated adverse effects were the most frequently reported health-related restrictions. In particular, psychometric evaluation by applying ePROs can detect health-related problems in patients with epilepsy. PMID: 29724486 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - April 30, 2018 Category: Neurology Authors: Bergmann M, Prieschl M, Walser G, Luef G, Rumpold G, Unterberger I Tags: Epilepsy Behav Source Type: research

Psychometric evaluation of the Epilepsy-related Fears in Parents Questionnaire.
TW Abstract OBJECTIVE: The aim of the article was to examine the psychometric properties of the Epilepsy-related Fears in Parents Questionnaire (EFPQ). METHOD: Internal consistency, factor structure, and construct validity were analyzed based on data from 291 parents participating in the baseline assessment of a quasi-experimental study on the efficacy of the FAMOSES (modulares Schulungsprogramm Epilepsie für Familien) parents' program. The control group of this study was used to calculate the test-retest reliability, while the responsiveness of the questionnaire was evaluated by comparing matched group...
Source: Epilepsy and Behaviour - April 30, 2018 Category: Neurology Authors: Hagemann A, Pfäfflin M, Nussbeck FW, May TW Tags: Epilepsy Behav Source Type: research