Hemispheric language lateralization in presurgical patients with temporal lobe epilepsy: Improving the retest reliability of functional transcranial Doppler sonography.
Abstract Since its introduction, functional transcranial Doppler sonography (fTCD) has been extensively applied in research and clinical settings and has now become part of the routine presurgical work-up of patients with epilepsy. Because of its importance in planning neurosurgical interventions and predicting possible cognitive risks, the reproducibility of fTCD in determining hemispheric language lateralization (HLL) has to be ensured. In the present study, fTCD was performed twice in 33 initially lateralized patients with temporal lobe epilepsy (TLE) as part of their presurgical work-up, using a standard word ...
Source: Epilepsy and Behaviour - September 11, 2018 Category: Neurology Authors: Conradi N, Hermsen A, Krause K, Gorny I, Strzelczyk A, Knake S, Rosenow F Tags: Epilepsy Behav Source Type: research

Ripple oscillations in the left temporal neocortex are associated with impaired verbal episodic memory encoding.
o DS, Worrell G, Sperling M, Weiss SA Abstract BACKGROUND: We sought to determine if ripple oscillations (80-120 Hz), detected in intracranial electroencephalogram (iEEG) recordings of patients with epilepsy, correlate with an enhancement or disruption of verbal episodic memory encoding. METHODS: We defined ripple and spike events in depth iEEG recordings during list learning in 107 patients with focal epilepsy. We used logistic regression models (LRMs) to investigate the relationship between the occurrence of ripple and spike events during word presentation and the odds of successful word recall following ...
Source: Epilepsy and Behaviour - September 11, 2018 Category: Neurology Authors: Waldman ZJ, Camarillo-Rodriguez L, Chervenova I, Berry B, Shimamoto S, Elahian B, Kucewicz M, Ganne C, He XS, Davis LA, Stein J, Das S, Gorniak R, Sharan AD, Gross R, Inman CS, Lega BC, Zaghloul K, Jobst BC, Davis KA, Wanda P, Khadjevand M, Tracy J, Rizzu Tags: Epilepsy Behav Source Type: research

Neuropsychology of frontal lobe epilepsy in children and adults: Systematic review and meta-analysis.
dez S Abstract Frontal lobe epilepsy (FLE) is associated with cognitive problems, especially in areas related to frontal lobe functioning as executive functions, attention, and motor skills, but with impact on memory and psychosocial adaptation. Deficits are similar in both adults and children with FLE, although no studies have compared adult and pediatric performance in the same study. The aim of this research was to analyze the existing evidence concerning the cognition in adults and children with FLE. A random effect meta-analysis was used using Cohen's d, and the confidence interval for each cognitive factor w...
Source: Epilepsy and Behaviour - September 10, 2018 Category: Neurology Authors: Verche E, San Luis C, Hernández S Tags: Epilepsy Behav Source Type: research

Epileptic auditory illusions as reliable findings in the determination of the lateralization and localization of epileptogenic zone.
Taşcı İ PMID: 30212724 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - September 10, 2018 Category: Neurology Authors: Balgetir F, Müngen B, Gönen M, Müngen E, Taşcı İ Tags: Epilepsy Behav Source Type: research

Cognitive features and surgical outcome of patients with long-term epilepsy-associated tumors (LEATs) within the temporal lobe.
CONCLUSION: Patients with LEATs in the temporal lobe frequently show cognitive impairments. Predictors for pre- and postoperative cognition mostly correspond to what is known for temporal lobe epilepsy and resections in general. However, different tumor types appear to be associated with different cognitive and seizure outcomes with astrocytoma as the least benefitted group. PMID: 30212725 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - September 10, 2018 Category: Neurology Authors: Vogt VL, Witt JA, Delev D, Grote A, von Lehe M, Becker AJ, Schramm J, Elger CE, Helmstaedter C Tags: Epilepsy Behav Source Type: research

Integrating the systematic assessment of psychological states in the epilepsy monitoring unit: Concept and compliance.
CONCLUSION: The results support the feasibility of high-frequency monitoring of psychological states and processes in routine EMU settings. Repeated daily collections four times per day of psychological surveys allow for the assessment of highly resolved, equidistant time series data, which gives insight into psychological states and processes during EMU admission. PMID: 30212726 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - September 10, 2018 Category: Neurology Authors: Michaelis R, Schöller H, Höller Y, Kalss G, Kirschner M, Schmid E, Trinka E, Schiepek G Tags: Epilepsy Behav Source Type: research

Caring electronically for young outpatients who have epilepsy.
CONCLUSIONS: The improved care delivery system that we envision includes self-management, electronic patient (or provider)-reported outcomes, on-going remote surveillance, and alerting/warning systems. This system and variants have the potential to reduce seizure burden through improved management, keep children out of the emergency department and hospital, and even reduce the number of outpatient visits. PMID: 30197227 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - September 6, 2018 Category: Neurology Authors: Oppenheimer J, Leviton A, Chiujdea M, Antonetty A, Ojo OW, Garcia S, Weas S, Fleegler EW, Chan E, Loddenkemper T Tags: Epilepsy Behav Source Type: research

Autism spectrum disorder, social communication difficulties, and developmental comorbidities in Sturge-Weber syndrome.
Abstract Sturge-Weber syndrome (SWS) is a neurocutaneous disorder characterized by the combination of a facial naevus flammeus and pial angioma, often associated with learning difficulties and/or epilepsy. Here, we report on the neuropsychological characteristics of a cohort of 92 children with SWS seen at a national referral center between 2002 and 2015. Almost a quarter (24%) had a diagnosis of autism spectrum disorder (ASD), with 45% overall having evidence of social communication difficulties (SCD). Autism spectrum disorder was more commonly seen in those individuals with bilateral angioma (p = 0.021). Sig...
Source: Epilepsy and Behaviour - September 6, 2018 Category: Neurology Authors: Gittins S, Steel D, Brunklaus A, Newsom-Davis I, Hawkins C, Aylett SE Tags: Epilepsy Behav Source Type: research

Is heart disease in chronic epilepsy a consequence of seizures or a fellow traveler?
PMID: 30153935 [PubMed - in process] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - August 30, 2018 Category: Neurology Authors: Verrier RL, Schachter SC Tags: Epilepsy Behav Source Type: research

Challenging behavior in adults with epilepsy and intellectual disability: An analysis of epilepsy characteristics.
CONCLUSION: Challenging behavior is a serious issue among adults with epilepsy and ID. Although some of the epilepsy and ID characteristics seemed to contribute independently to these types of challenging behavior, the effects of epilepsy-related characteristics are modest when compared with ID. PMID: 30153936 [PubMed - in process] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - August 30, 2018 Category: Neurology Authors: van Ool JS, Snoeijen-Schouwenaars FM, Tan IY, Jurgen Schelhaas H, Aldenkamp AP, Hendriksen JGM Tags: Epilepsy Behav Source Type: research

Callosotomy in children - Parental experiences reported at long-term follow-up.
Abstract Callosotomy is a palliative surgery method for selected individuals with severe, drug-resistant epilepsy. The aim of this retrospective study was to explore parental experiences of the family's life situation before and long after their child had undergone callosotomy. Semistructured interviews of the parents of 12 children were analyzed using a combination of inductive and deductive qualitative content analysis. Before surgery, parents felt that they lived in a chaotic bubble with an unbearable situation; their child had severe and frequent seizures and had to be looked after constantly. Most parents wer...
Source: Epilepsy and Behaviour - August 30, 2018 Category: Neurology Authors: Ozanne A, Verdinelli C, Olsson I, Edelvik A, H Graneheim U, Malmgren K Tags: Epilepsy Behav Source Type: research

Common psychiatric comorbidities in epilepsy: How big of a problem is it?
Abstract Psychiatric illness and epilepsy commonly co-occur in adults and in children and adolescents. Theories of comorbidity are complex, but recurring associations between the conditions suggest overlap that is more than simple co-occurrence. Common underlying pathophysiology may imply that epilepsy itself may constituently include psychiatric symptoms. Conditions such as depression or cognitive difficulties commonly occur and in some cases, are considered to be associated with specific epilepsy characteristics such as localization or seizure type. Regardless of etiologic attributions to psychiatric comorbidity...
Source: Epilepsy and Behaviour - August 25, 2018 Category: Neurology Authors: Salpekar JA, Mula M Tags: Epilepsy Behav Source Type: research

Does pain sensitivity increase during ictal period? Evidence from absence epileptic WAG/Rij rats.
CONCLUSION: Our data indicate higher pain sensitivity during the ictal period in absence epilepsy rats. Considering the fact that subjects are less responsive during spike-wave discharges, there is a decrease in the level of consciousness and/or responsiveness ictally during all generalized genetic seizures, this increased pain sensitivity is rather surprising during the ictal period. Although the mechanism remains unknown, this novel finding deserves further investigation. PMID: 30153651 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - August 25, 2018 Category: Neurology Authors: Velioglu SK, Gedikli O, Yıldırım M, Ayar A Tags: Epilepsy Behav Source Type: research

Test-specific differences in verbal memory assessments used prior to surgery in temporal lobe epilepsy.
CONCLUSIONS: The construct structure of the two verbal memory differs. It was shown that the RAVLT correlated with visuospatial memory, whereas the CDT did not. The study highlights that there are important nonoverlapping features regarding verbal recall of the two tests, indicating that these tests cannot fully replace one another. PMID: 30153652 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - August 25, 2018 Category: Neurology Authors: Ljung H, Strandberg MC, Björkman-Burtscher IM, Psouni E, Källén K Tags: Epilepsy Behav Source Type: research

Overall and cause-specific premature mortality in epilepsy: A systematic review.
CONCLUSIONS: Despite the heterogeneity in reports, our findings support the suggestions that people with epilepsy have an increased risk of premature mortality from various causes. Further work is needed to elucidate the mechanisms, to determine biomarkers for predicting those at risk, and to understand the implications of counseling and preventive strategies. PMID: 30154056 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - August 25, 2018 Category: Neurology Authors: Watila MM, Balarabe SA, Ojo O, Keezer MR, Sander JW Tags: Epilepsy Behav Source Type: research

The epilepsy transition care gap in young adults with childhood-onset epilepsy.
The objective of the study was to assess the extent to which epilepsy transition discussions occurred in adolescents with childhood-onset epilepsy prior to the age of attaining majority (prior to their 18th birthday) in a community-based cohort of individuals with childhood-onset epilepsy followed longitudinally. METHODS: The Connecticut Study of Epilepsy is a prospective, community-based study of newly diagnosed childhood-onset epilepsy with 613 children (onset 
Source: Epilepsy and Behaviour - August 25, 2018 Category: Neurology Authors: Baca CM, Barry F, Berg AT Tags: Epilepsy Behav Source Type: research

Widespread white matter DTI alterations in mesial temporal sclerosis independent of disease side.
aretto EL Abstract PURPOSE: The aim of this study was to evaluate white matter (WM) integrity in vivo in patients with unilateral mesial temporal sclerosis (MTS). METHODS: Diffusion tensor imaging (DTI) findings from patients with left-sided MTS (L-MTS; N = 14) and right-sided MTS (R-MTS; N = 13), all taking antiepileptic medication, were compared with those from gender- and age-matched controls; DTI was performed along 30 noncollinear directions in a 1.5-T scanner. Tract-based spatial statistics (TBSS) analysis was performed by creating a WM skeleton; 5000-permutation-based inference (threshold, p 
Source: Epilepsy and Behaviour - August 24, 2018 Category: Neurology Authors: Corrêa DG, Pereira M, Zimmermann N, Doring T, Ventura N, Rêgo C, Marcondes J, Alves-Leon SV, Gasparetto EL Tags: Epilepsy Behav Source Type: research

Hippocampal neuropeptide Y protein expression following controlled cortical impact and posttraumatic epilepsy.
This study assessed neuropeptide Y (NPY) expression in the hippocampus after long-term survival following traumatic brain injury (TBI) induced by controlled cortical impact (CCI) with or without the development of posttraumatic epilepsy (PTE). We hypothesized that following long-term survival after CCI, the severity of tissue injury and the development of PTE would correlate with the degree of hippocampal neurodegeneration as reflected by NPY+ and neuronal nuclear antigen (NeuN)+ cell loss. Adult Sprague-Dawley rats of 2-3 months of age were lesioned in the right parietal cortex and monitored for seizure activity by vide...
Source: Epilepsy and Behaviour - August 23, 2018 Category: Neurology Authors: Sun Z, Liu S, Kharlamov EA, Miller ER, Kelly KM Tags: Epilepsy Behav Source Type: research

Parental coping and its role in predicting health-related quality of life in pediatric epilepsy.
This study assessed the relationship of parental coping with HRQOL and other clinical and sociodemographic factors. METHODS: Data included parental ratings on the Illness Cognition Questionnaire-Parent (ICQ-P) and the Quality of Life in Childhood Epilepsy (QOLCE) questionnaire for 108 children and adolescents with epilepsy (mean 11.34 years of age). The ICQ-P examines parental coping through constructs of illness cognitions while QOLCE determines overall functioning as indicated by parents. Bivariate correlations were conducted to identify significant associations with parental coping, followed by a multiple linear ...
Source: Epilepsy and Behaviour - August 23, 2018 Category: Neurology Authors: McLaughlin RM, Schraegle WA, Nussbaum NL, Titus JB Tags: Epilepsy Behav Source Type: research

Neurostimulation for the treatment of epilepsy.
PMID: 30135047 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - August 19, 2018 Category: Neurology Authors: Benbadis SR Tags: Epilepsy Behav Source Type: research

Effectiveness of antiepileptic drug tapering in the pediatric epilepsy monitoring unit.
Abstract OBJECTIVE: Limited evidence on the relationship between antiepileptic drug (AED) tapering and the likelihood of a seizure during an Epilepsy Monitoring Unit (EMU) admission is available, and no evidence specific to the pediatric population has been published. Our study sought to determine whether AED tapering leads to increased seizure likelihood in a pediatric EMU setting. METHODS: We performed a retrospective chart review of children admitted to the pediatric EMU at the Hospital for Sick Children in Toronto between June 1, 2014 and June 1, 2016. Data collected included demographics, reason for EMU ...
Source: Epilepsy and Behaviour - August 18, 2018 Category: Neurology Authors: Keller AE, Bradbury L, Wang L, Yau I, Donner EJ Tags: Epilepsy Behav Source Type: research

Termination of pregnancy in women with epilepsy - A retrospective single center study.
Abstract Antiepileptic drugs (AEDs) are commonly prescribed to women of childbearing age. As 0.3%-0.7% of all pregnancies occur in women with epilepsy (WWE), the effect of recurrent seizures and teratogenicity on pregnancy outcome and the fetus have been widely studied. Most of these studies have focused on live births. A significant number of terminated pregnancies in WWE were ignored in past studies, thus reducing the calculated incidence of congenital malformations and possible influence of AED exposure. We scrutinized the medical records at our medical center for termination of pregnancy (TOP) in WWE for the y...
Source: Epilepsy and Behaviour - August 18, 2018 Category: Neurology Authors: Goldstein L, Shihman B, Amiel N, Benninger F Tags: Epilepsy Behav Source Type: research

Telephonic review of patients with epilepsy - An underutilized resource.
PMID: 30131225 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - August 18, 2018 Category: Neurology Authors: Singh MB Tags: Epilepsy Behav Source Type: research

Frequency of drug combinations between enzyme-inducing first-generation antiepileptic drugs and inducible drugs in patients with epilepsy.
CONCLUSIONS: Patients with epilepsy treated with traditional EIAEDs are at a very high risk of drug interactions. PMID: 30126756 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - August 17, 2018 Category: Neurology Authors: Zaccara G, Gualdani E, Policardo L, Palumbo P, Francesconi P Tags: Epilepsy Behav Source Type: research

Renaming Korean epilepsy: Where are we?
Abstract OBJECTIVE: The Korean name of epilepsy was renamed in 2011 to reflect the modern scientific evidence and to avoid misconceptions of epilepsy. However, the degree of dissemination of the new name of epilepsy had not been studied in Korea. To determine the degree of dissemination of the new name, we retrieved the relative Internet search volume of the new name and the old name using Naver, a dominant Internet search engine in Korea. METHODS: The relative search volume is referred to as the Naver Trend Index (NTI). Naver DataLab provides the information on queries only from January 2016, and we download...
Source: Epilepsy and Behaviour - August 17, 2018 Category: Neurology Authors: Ji KH Tags: Epilepsy Behav Source Type: research

Experiences and perspectives of stigmatization and discrimination against people with epilepsy in Accra, Ghana.
Abstract A qualitative research approach was utilized to investigate experiences and perspectives of people with epilepsy (PWE) and key informants. Twenty participants (14 PWE and 6 key informants) were purposively selected as participants for the study and in-depth interviews were conducted. The interviews were audio-recorded, transcribed, and analyzed to identify emerging themes that addressed objectives of the study. The findings indicated that PWE and key informants included in this study perceived epilepsy as a spiritual, curable, and medical condition. Besides, it was found that for fear of being infected by...
Source: Epilepsy and Behaviour - August 17, 2018 Category: Neurology Authors: Dako-Gyeke M, Donkor MD Tags: Epilepsy Behav Source Type: research

Patterns of antiepileptic drug use in patients with potential refractory epilepsy in Texas Medicaid.
This study compared treatment patterns (adherence, persistence, addition, and switching) associated with refractory and nonrefractory epilepsy. METHODS: Texas Medicaid claims from 09/01/07-12/31/13 were analyzed, and patients eligible for the study 1) were between 18 and 62 years of age, 2) had a prescription claim for an AED during the identification period (03/01/08-12/31/11) with no prior baseline AED use (6-month), and 3) had evidence of epilepsy diagnosis within 6 months of AED use. Based on AED use in the identification period, patients were categorized into "refractory" (≥3AEDs) and "nonrefractory" (
Source: Epilepsy and Behaviour - August 14, 2018 Category: Neurology Authors: Gupte-Singh K, Wilson JP, Barner JC, Richards KM, Rascati KL, Hovinga C Tags: Epilepsy Behav Source Type: research

Abnormal cortical activation during an auditory word comprehension task in benign childhood epilepsy with centrotemporal spikes: A magnetoencephalographic study.
CONCLUSION: Epileptic spikes negatively influenced responsiveness to the auditory language comprehension task in the language-associated cortices. These findings suggest that epileptic spikes could have a negative impact on the functional activity in rolandic areas and become a reason to change the functional development of the language network. PMID: 30120072 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - August 14, 2018 Category: Neurology Authors: Kagitani-Shimono K, Kato Y, Hanaie R, Matsuzaki J, Tanigawa J, Iwatani Y, Azuma J, Taniike M Tags: Epilepsy Behav Source Type: research

Depressive symptoms and suicidality among individuals with epilepsy enrolled in self-management studies: Results from the US Centers for Disease Control and Prevention Managing Epilepsy Well (MEW) Network.
We examined correlates of depressive symptoms and suicidal ideation in adults using pooled data from epilepsy self-management studies conducted by sites in the Centers for Disease Control and Prevention (CDC) Research Center's Managing Epilepsy Well (MEW) Network that assessed depression severity with the 9-item Patient Health Questionnaire (PHQ-9). Of the 770 subjects in the analysis (mean age 42.4 ± 13.0 years), the mean total PHQ-9 score was 9.4 ± 6.6 and 334 subjects (43.4%) had moderate to severe depressive symptoms (PHQ-9 ≥ 10). Only ongoing seizures and low education were associated wi...
Source: Epilepsy and Behaviour - August 13, 2018 Category: Neurology Authors: Friedman D, Spruill TM, Liu H, Tatsuoka C, Stoll S, Jobst BC, Fraser RT, Johnson EK, Chaytor N, Sajatovic M Tags: Epilepsy Behav Source Type: research

Negative effects of interictal spikes on theta rhythm in human temporal lobe epilepsy.
Abstract Interictal spike is a biomarker of epilepsy that can occur frequently between seizures. Its potential effects on brain oscillations, especially on theta rhythm (4-8 Hz) that is related to a variety of cognitive processes, remain controversial. Using local field potentials recorded from patients with temporal lobe epilepsy (TLE), we investigated here the impact of spikes on theta rhythm immediately after spikes and during the prolonged periods (lasting 4-36 s) between adjacent spikes. Local field potentials (LFPs) were recorded in different epileptogenic areas including the anterior hippocampus (aH) an...
Source: Epilepsy and Behaviour - August 13, 2018 Category: Neurology Authors: Fu X, Wang Y, Ge M, Wang D, Gao R, Wang L, Guo J, Liu H Tags: Epilepsy Behav Source Type: research

"Ictal epileptic headache" and the revised International Headache Classification (ICHD-3) published in Cephalalgia 2018, vol. 38(1) 1-211: Not just a matter of definition!
"Ictal epileptic headache" and the revised International Headache Classification (ICHD-3) published in Cephalalgia 2018, vol. 38(1) 1-211: Not just a matter of definition! Epilepsy Behav. 2018 Aug 13;: Authors: Parisi P, Belcastro V, Verrotti A, Striano P, Kasteleijn-Nolst Trenitè DGA PMID: 30115602 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - August 13, 2018 Category: Neurology Authors: Parisi P, Belcastro V, Verrotti A, Striano P, Kasteleijn-Nolst Trenitè DGA Tags: Epilepsy Behav Source Type: research

Brain network alterations of mesial temporal lobe epilepsy with cognitive dysfunction following anterior temporal lobectomy.
Abstract The aims of this study were to investigate the brain network connectivity alterations of intractable unilateral mesial temporal lobe epilepsy (MTLE) with cognitive dysfunction before and after anterior temporal lobectomy (ATL) using resting-state functional magnetic resonance imaging (rs-fMRI) study and to further observe the correlation between the brain network connectivity with cognitive performance. Fourteen patients with unilateral left MTLE before and after ATL were compared with thirty healthy controls (HCs) on functional connectivity (FC) between resting-state networks (RSNs). The correlation betw...
Source: Epilepsy and Behaviour - August 13, 2018 Category: Neurology Authors: Zhang C, Yang H, Liu C, Zhang G, Chen N, Li K Tags: Epilepsy Behav Source Type: research

Sodium cromoglycate reduces short- and long-term consequences of status epilepticus in rats.
SA, Rocha L Abstract Several studies indicate that sodium cromoglycate (CG) induces neuroprotective effects in acute neurological conditions. The present study focused on investigating if the use of CG in rats during the post-status epilepticus (post-SE) period reduces the acute and long-term consequences of seizure activity. Our results revealed that animals that received a single dose of CG (50 mg/kg s.c.: subcutaneously) during the post-SE period showed a lower number of neurons in the process of dying in the dentate gyrus, hilus, cornu ammonis 1 (CA1), and CA3 of the dorsal hippocampus than the rats that rec...
Source: Epilepsy and Behaviour - August 13, 2018 Category: Neurology Authors: Valle-Dorado MG, Santana-Gómez CE, Orozco-Suárez SA, Rocha L Tags: Epilepsy Behav Source Type: research

Executive and behavioral functioning in pediatric frontal lobe epilepsy.
CONCLUSION: Ratings on the BRIEF, CBCL, and TRF are moderately to highly correlated, suggesting a (strong) link between executive and behavioral functioning. Subtle differences between parents and teachers ratings suggest different executive function demands in various settings. PMID: 30115605 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - August 13, 2018 Category: Neurology Authors: van den Berg L, de Weerd A, Reuvekamp M, Hagebeuk E, van der Meere J Tags: Epilepsy Behav Source Type: research

Localizing and lateralizing values of postictal behavioral impairments in epileptic rats.
Abstract Transient postictal behavioral impairments in patients with epilepsy provide clues to seizure localization, but no attempt has been made previously to study the localization/lateralization value of postseizure motor disturbances in experimental models of epilepsy. The present study investigated relation of postictal motor deficit to seizure localization in the rat model of sound-induced reflex epilepsy. Sound-induced motor seizures started with a focal brainstem seizure (running) and progressed to a secondarily generalized seizure. Depending on innate or acquired seizure susceptibility of rats, focal brai...
Source: Epilepsy and Behaviour - August 11, 2018 Category: Neurology Authors: Vinogradova LV, Shatskova AB Tags: Epilepsy Behav Source Type: research

Cannabidiol improves frequency and severity of seizures and reduces adverse events in an open-label add-on prospective study.
The objective of this study was to characterize the changes in adverse events, seizure severity, and frequency in response to a pharmaceutical formulation of highly purified cannabidiol (CBD; Epidiolex®) in a large, prospective, single-center, open-label study. We initiated CBD in 72 children and 60 adults with treatment-resistant epilepsy (TRE) at 5 mg/kg/day and titrated it up to a maximum dosage of 50 mg/kg/day. At each visit, we monitored treatment adverse events with the adverse events profile (AEP), seizure severity using the Chalfont Seizure Severity Scale (CSSS), and seizure frequency (SF) using seizure cal...
Source: Epilepsy and Behaviour - August 9, 2018 Category: Neurology Authors: Szaflarski JP, Bebin EM, Cutter G, DeWolfe J, Dure LS, Gaston TE, Kankirawatana P, Liu Y, Singh R, Standaert DG, Thomas AE, Ver Hoef LW, UAB CBD Program Tags: Epilepsy Behav Source Type: research

Comparative effectiveness of add-on therapy with newer-generation antiepileptic drugs in Bulgarian patients with refractory epilepsy.
CONCLUSION: Despite some similar characteristics of newer-generation antiepileptic drugs' effectiveness, levetiracetam stands out with better dynamic improvement of seizure severity and frequency and satisfactory tolerability; typical for pregabalin is a very good dynamic improvement of seizure severity and frequency mainly in patients with focal seizures, but a lower tolerability, and the main advantage of oxcarbazepine is a good tolerability, efficacy, however, is less satisfactory. PMID: 30097339 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - August 7, 2018 Category: Neurology Authors: Viteva E, Zahariev Z Tags: Epilepsy Behav Source Type: research

The impact of sleep characteristics and epilepsy variables on memory performance in patients with focal seizures.
In this study, we investigated the relationships between sleep, epilepsy, and objective memory performance variables. Twenty-five patients with focal seizures had their memory tested while undergoing a two-day ambulatory electroencephalography (EEG). The sleep variables of interest were the percentage of time spent in SWS (%SWS) and REM latency. Epilepsy variables included the presence of (1) seizures, (2) interictal epileptiform discharges, and/or (3) hippocampal lesions as well as site of seizure origin (temporal vs extratemporal). Overnight retention (of autobiographical events, a story, and a complex geometric figure) ...
Source: Epilepsy and Behaviour - August 7, 2018 Category: Neurology Authors: van Schalkwijk FJ, Ricci M, Nikpour A, Miller LA Tags: Epilepsy Behav Source Type: research

Navigated transcranial magnetic stimulation for preoperative cortical mapping of expressive language in children: Development of a method.
hordstein M Abstract We adjusted an object-naming task with repetitive navigated transcranial magnetic stimulation (rnTMS) originally developed for preoperative cortical language mapping in adults in order for it to be used in children. Two series of pictures were chosen for children above and below 10 years of age, respectively. Firstly, the series of pictures and the preferred speed of presentation were assessed for their applicability in children of different ages and abilities. Secondly, these series were used with rnTMS preoperatively in five children with epilepsy. Naming errors induced by the stimulation ...
Source: Epilepsy and Behaviour - August 7, 2018 Category: Neurology Authors: Rejnö-Habte Selassie G, Pegenius G, Viggedal G, Hallböök T, Thordstein M Tags: Epilepsy Behav Source Type: research

Machine learning as a new paradigm for characterizing localization and lateralization of neuropsychological test data in temporal lobe epilepsy.
This study adds to the existing literature by employing an analytic technique with inherent advantages in generalizability when compared to traditional single-sample, not cross-validated models. In the future, class probabilities extracted from these and similar analyses could supplement neuropsychological practice by offering a quantitative guide to clinical judgements. PMID: 30082202 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - August 3, 2018 Category: Neurology Authors: Frank B, Hurley L, Scott TM, Olsen P, Dugan P, Barr WB Tags: Epilepsy Behav Source Type: research

Close to 1 million US adults aged 55  years or older have active epilepsy-National Health Interview Survey, 2010, 2013, and 2015.
This study uses the most recent data from the 2010, 2013, and 2015 National Health Interview Survey (NHIS) to provide updated national estimates of epilepsy prevalence among US adults aged 55 years or older to help guide public health action. We used the following validated surveillance case definition for active epilepsy: adults with self-reported doctor-diagnosed epilepsy or seizure disorder who reported either currently taking medications to treat their epilepsy or seizure disorder or at least one seizure during the past 12 months. We estimated the prevalence of active epilepsy to be 1.4% (about 529,000) among US ad...
Source: Epilepsy and Behaviour - August 2, 2018 Category: Neurology Authors: Sapkota S, Kobau R, Pastula DM, Zack MM Tags: Epilepsy Behav Source Type: research

Depressive, inflammatory, and metabolic factors associated with cognitive impairment in patients with epilepsy.
Abstract PURPOSE: The purpose of this study was to examine the cognitive function and depressive traits most frequently associated with the clinical assessment of patients with epilepsy and if these clinical parameters are linked to glycolipid levels and inflammatory and apoptotic markers. METHODS: Patients with epilepsy (n = 32) and healthy subjects (n = 41) were recruited to participate in this study. Neuropsychological evaluation was performed in both groups through a battery of cognitive tests. Inflammatory markers, apoptotic factors, and deoxyribonucleic acid (DNA) damage were measured in blood s...
Source: Epilepsy and Behaviour - August 2, 2018 Category: Neurology Authors: Arend J, Kegler A, Caprara ALF, Almeida C, Gabbi P, Pascotini ET, de Freitas LAV, Miraglia C, Bertazzo TL, Palma R, Arceno P, Duarte MMMF, Furian AF, Oliveira MS, Royes LFF, Mathern GW, Fighera MR Tags: Epilepsy Behav Source Type: research

Future development of a depot antiepileptic drug: What are the ethical implications?
Abstract Depot medications have been used for long-term treatment of many different medical conditions (schizophrenia, opioid addiction) and for prevention of pregnancy (birth control). In addition, proposals for depot medication for antidepressants have been made as a possible treatment for chronic depression. For the treatment of chronic epilepsy, there are currently no depot antiepileptic drugs (AEDs). However, there may be a role for them. Depot AEDs could improve medication adherence rates, thereby reducing the morbidity and mortality that are associated with ongoing seizures. This could help to reduce hospit...
Source: Epilepsy and Behaviour - July 24, 2018 Category: Neurology Authors: Sequeira AJ, Buchman S, Lewis A, Karceski S Tags: Epilepsy Behav Source Type: research

Efficacy and tolerability of perampanel in children and adolescents with pharmacoresistant epilepsy: The first real-world evaluation in Asian pediatric neurology clinics.
CONCLUSION: The current data support the value of adjunctive PER in child and adolescent patients with pharmacoresistant epilepsy in daily clinical practice. Perampanel was efficacious and generally well-tolerated as an add-on treatment for epilepsy. PMID: 30032806 [PubMed - in process] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - July 24, 2018 Category: Neurology Authors: Lin KL, Lin JJ, Chou ML, Hung PC, Hsieh MY, Chou IJ, Lim SN, Wu T, Wang HS Tags: Epilepsy Behav Source Type: research

The challenges of assessing effectiveness of lacosamide using electronic medical record databases.
CONCLUSION: Lacosamide monotherapy effectiveness was not estimated because the EHR prescription record data did not have sufficient information on days supply. Additionally, most patients' records did not contain adequate information to allow for evaluation of quantitative changes in seizure frequency based on the number of seizures per month. More studies are needed to validate these study findings. PMID: 30032807 [PubMed - in process] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - July 24, 2018 Category: Neurology Authors: Kalilani L, Halpern R, Seare J, Dedeken P Tags: Epilepsy Behav Source Type: research

Children with autism spectrum disorders and drug-resistant epilepsy can benefit from epilepsy surgery.
CONCLUSION: A subset of children with ASD can benefit from resective surgery, and for those who are not candidates, a VNS can offer significant improvements in seizure control. PMID: 30032808 [PubMed - in process] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - July 24, 2018 Category: Neurology Authors: Morrison-Levy N, Go C, Ochi A, Otsubo H, Drake J, Rutka J, Weiss SK Tags: Epilepsy Behav Source Type: research

Predictors of nonadherence in children and adolescents with epilepsy: A multimethod assessment approach.
CONCLUSION: The use of a multimethod approach for assessing adherence increases sensitivity for detection of nonadherence to AEDs. Disease duration and parental necessity beliefs and concerns assessed by the BMQ-specific questionnaire were significant predictors of nonadherence to the AED therapy. The need for the development and implementation of interventions that can be employed to improve adherence within this pediatric population has been highlighted by the high levels of nonadherence identified. PMID: 30032809 [PubMed - in process] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - July 24, 2018 Category: Neurology Authors: Alsous M, Hamdan I, Saleh M, McElnay J, Horne R, Masri A Tags: Epilepsy Behav Source Type: research

Relationships between knowledge, attitudes, stigma, anxiety and depression, and quality of life in epilepsy: A structural equation modeling.
CONCLUSION: Mental health and quality of life of patient with epilepsy are closely related to the knowledge, attitude, and perceived stigma of the patients. Therefore, educating/supporting patients can help increase the mental health and quality of life. PMID: 30032810 [PubMed - in process] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - July 24, 2018 Category: Neurology Authors: Yeni K, Tulek Z, Simsek OF, Bebek N Tags: Epilepsy Behav Source Type: research

Neuropsychological profile of mild temporal lobe epilepsy.
Abstract OBJECTIVE: In the current literature, whether patients with mild mesial temporal lobe epilepsy (mMTLE) have typical neurocognitive profile similar to patients with treatment-refractory seizures still remains unknown. The purpose of the present work was to analyze the neuropsychological profile in a group of consecutive patients with mMTLE. METHODS: Forty consecutive patients whose conditions were diagnosed with mMTLE and 30 healthy controls (HC) were evaluated with an extensive neuropsychological battery. In addition, self-report questionnaires were also administered to evaluate the subjective impair...
Source: Epilepsy and Behaviour - July 24, 2018 Category: Neurology Authors: Vaccaro MG, Trimboli M, Scarpazza C, Palermo L, Bruni A, Gambardella A, Labate A Tags: Epilepsy Behav Source Type: research

Environmental enrichment alleviates cognitive and behavioral impairments in EL mice.
Abstract Epilepsy in children is occasionally associated with comorbidities, such as cognitive impairment, behavioral disturbances, and social deficits. These neurobehavioral comorbidities are closely related to environmental factors and the severity of the seizures. Previous studies show that environmental enrichment has a beneficial effect in animal models of temporal lobe epilepsy following systemic chemoconvulsant administration. However, the effect of environmental enrichment on behavioral impairments in the EL mouse, a genetic model of human idiopathic epilepsy, remains unknown. In the present study, we exam...
Source: Epilepsy and Behaviour - July 24, 2018 Category: Neurology Authors: Suemaru K, Yoshikawa M, Aso H, Watanabe M Tags: Epilepsy Behav Source Type: research