An exploration of the experiences of self-disgust in people with epilepsy
This study was the first to explore qualitatively the experiences of self-disgust in people with epilepsy. People with epilepsy experience disgust in reaction to the physical symptoms of seizures and these disgust-based feelings appeared to become internalized following others' disgust reactions. Avoidance as a strategy to manage self-disgust could be protective but might have inadvertently maintained feelings of self-disgust.PMID:34864376 | DOI:10.1016/j.yebeh.2021.108435 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - December 5, 2021 Category: Neurology Authors: Rebecca Mayor Markus Reuber Sabir Giga Jane Simpson Source Type: research

Does the type of seizure influence heart rate variability changes?
CONCLUSION: This work emphasizes the greater effect of FBTCS in autonomic cardiac function in patients with refractory epilepsy, compared to other types of seizures, with a significant reduction in vagal tonus, which may be associated with an increased risk of SUDEP.PMID:34864377 | DOI:10.1016/j.yebeh.2021.108453 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - December 5, 2021 Category: Neurology Authors: Maria Teresa Faria Susana Rodrigues Manuel Campelo Duarte Dias Ricardo Rego Helena Rocha Francisca S á Marta Tavares-Silva Roberto Pinto Gon çalo Pestana Ana Oliveira Jorge Pereira Jo ão Paulo Silva Cunha Francisco Rocha-Gon çalves Hern âni Gonçalve Source Type: research

Polypharmacy composition and patient- and provider-related variation in patients with epilepsy
CONCLUSION: Patients with epilepsy fill a large number of medications from a large number of providers, including high-risk medications. Variation in medication fills was substantially more related to provider-to-provider rather than patient-to-patient variation. The better understanding of drivers of high-prescribing practices may reduce avoidable medication-related harms.PMID:34864378 | DOI:10.1016/j.yebeh.2021.108428 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - December 5, 2021 Category: Neurology Authors: Samuel W Terman Carole E Aubert Donovan T Maust Chloe E Hill Chun C Lin James F Burke Source Type: research

Status of epileptic spasms: A study of 21 children
CONCLUSION: In this study we identified patients with WS and other types of severe non-West epilepsy syndromes who had a particular type of long-lasting ES that, in spite of its long duration does not strictly meet the criteria of the International League against Epilepsy (ILAE) classification of status epilepticus, may be considered a spasm status.PMID:34864379 | DOI:10.1016/j.yebeh.2021.108451 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - December 5, 2021 Category: Neurology Authors: Roberto Caraballo Marcos Semprino Lorena Fasulo Gabriela Reyes Santiago Chac ón Adolfo Gallo Celeste Buompadre Source Type: research

Indirect treatment comparison of cenobamate to other ASMs for the treatment of uncontrolled focal seizures
Epilepsy Behav. 2021 Dec 1;126:108429. doi: 10.1016/j.yebeh.2021.108429. Online ahead of print.ABSTRACTOBJECTIVE: The efficacy and safety of cenobamate relative to other antiseizure medications (ASMs) has not been evaluated. An indirect treatment comparison (network meta-analysis) was performed to determine if adjunctive cenobamate increases the odds ratio (OR) for ≥50% responder rate or for withdrawals due to treatment-emergent adverse events (TEAEs) leading to ASM discontinuation versus adjunctive therapy with other ASMs.METHODS: A systematic literature review was conducted to identify randomized, double-blind, placeb...
Source: Epilepsy and Behaviour - December 5, 2021 Category: Neurology Authors: Michael Privitera Florent F Richy Vernon F Schabert Source Type: research

Epidemiology, healthcare resource use, and mortality in patients with probable Dravet syndrome: A population-based study on German health insurance data
Epilepsy Behav. 2021 Dec 1;126:108442. doi: 10.1016/j.yebeh.2021.108442. Online ahead of print.ABSTRACTOBJECTIVE: Ten-year retrospective study to assess burden of illness in patients with probable Dravet syndrome (DS) identified from German healthcare data.METHODS: In the absence of an International Classification of Diseases code, patients with probable DS were identified using a selection algorithm considering diagnoses and drug prescriptions. Primary analyses were prevalence and demographics; secondary analyses included healthcare costs, annual hospitalization rate (AHR) and length of stay (LOS), medication use, and mor...
Source: Epilepsy and Behaviour - December 5, 2021 Category: Neurology Authors: Susanne Schubert-Bast Lara Kay Andreas Simon Geoffrey Wyatt Rowena Holland Felix Rosenow Adam Strzelczyk Source Type: research

Marital status among patients with epilepsy in Saudi Arabia
Epilepsy Behav. 2021 Dec 1;126:108452. doi: 10.1016/j.yebeh.2021.108452. Online ahead of print.ABSTRACTThere are no adequate studies on Saudi Arabia regarding the effect of the social environment on marriage among people with epilepsy (PWE). To fill this gap in the literature, we investigated the marital status of PWE to determine the factors affecting their marital prospects. The subjects of the study included PWE aged 18 years or above, recruited between 1998 and 2019 from the Epilepsy Registry of King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia. We collected a wide range of socio-demographic dat...
Source: Epilepsy and Behaviour - December 5, 2021 Category: Neurology Authors: Manal Almarzouqi Saleh Alageel Amani Almeharish Abdulaziz Alsemari Source Type: research

Prescription patterns and dosages of antiepileptic drugs in prevalent patients with epilepsy in Taiwan: A nationwide retrospective cross-sectional study
Epilepsy Behav. 2021 Dec 2;126:108450. doi: 10.1016/j.yebeh.2021.108450. Online ahead of print.ABSTRACTOBJECTIVE: To evaluate the prescription patterns and prescribed daily dose (PDD)/defined daily dose (DDD) ratios of antiepileptic drugs (AEDs) in prevalent patients with epilepsy in Taiwan.MATERIALS AND METHODS: A nationwide retrospective cross-sectional study was conducted for prevalent patients with epilepsy in 2016 using the Taiwanese National Health Insurance Research Database. The prescription records of AEDs of all prevalent patients with epilepsy were retrieved. The mean PDDs and PDD/DDD ratios of AEDs in adult pat...
Source: Epilepsy and Behaviour - December 5, 2021 Category: Neurology Authors: Chun-Yu Liang Kuo-Liang Chiang Liang-Po Hsieh Li-Nien Chien Source Type: research

Infantile spasms: Knowledge, attitude, and practice of pediatricians in Turkey
CONCLUSION: Our findings highlight the importance of medical education as awareness is critical for diagnosing ISS. To facilitate rapid diagnosis, it is also important to combine medical education with public action. To ensure a sufficient level of knowledge about epileptic spasms and ISS, a strategy based on the socio-cultural characteristics of each population should be developed.PMID:34864626 | DOI:10.1016/j.yebeh.2021.108456 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - December 5, 2021 Category: Neurology Authors: Deniz Y ılmaz Özlem Yayıcı Köken Esra G ürkaş Nesrin Ceylan Ay şegül Neşe Çıtak Kurt Source Type: research

An exploration of the experiences of self-disgust in people with epilepsy
This study was the first to explore qualitatively the experiences of self-disgust in people with epilepsy. People with epilepsy experience disgust in reaction to the physical symptoms of seizures and these disgust-based feelings appeared to become internalized following others' disgust reactions. Avoidance as a strategy to manage self-disgust could be protective but might have inadvertently maintained feelings of self-disgust.PMID:34864376 | DOI:10.1016/j.yebeh.2021.108435 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - December 5, 2021 Category: Neurology Authors: Rebecca Mayor Markus Reuber Sabir Giga Jane Simpson Source Type: research

Does the type of seizure influence heart rate variability changes?
CONCLUSION: This work emphasizes the greater effect of FBTCS in autonomic cardiac function in patients with refractory epilepsy, compared to other types of seizures, with a significant reduction in vagal tonus, which may be associated with an increased risk of SUDEP.PMID:34864377 | DOI:10.1016/j.yebeh.2021.108453 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - December 5, 2021 Category: Neurology Authors: Maria Teresa Faria Susana Rodrigues Manuel Campelo Duarte Dias Ricardo Rego Helena Rocha Francisca S á Marta Tavares-Silva Roberto Pinto Gon çalo Pestana Ana Oliveira Jorge Pereira Jo ão Paulo Silva Cunha Francisco Rocha-Gon çalves Hern âni Gonçalve Source Type: research

Polypharmacy composition and patient- and provider-related variation in patients with epilepsy
CONCLUSION: Patients with epilepsy fill a large number of medications from a large number of providers, including high-risk medications. Variation in medication fills was substantially more related to provider-to-provider rather than patient-to-patient variation. The better understanding of drivers of high-prescribing practices may reduce avoidable medication-related harms.PMID:34864378 | DOI:10.1016/j.yebeh.2021.108428 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - December 5, 2021 Category: Neurology Authors: Samuel W Terman Carole E Aubert Donovan T Maust Chloe E Hill Chun C Lin James F Burke Source Type: research

Status of epileptic spasms: A study of 21 children
CONCLUSION: In this study we identified patients with WS and other types of severe non-West epilepsy syndromes who had a particular type of long-lasting ES that, in spite of its long duration does not strictly meet the criteria of the International League against Epilepsy (ILAE) classification of status epilepticus, may be considered a spasm status.PMID:34864379 | DOI:10.1016/j.yebeh.2021.108451 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - December 5, 2021 Category: Neurology Authors: Roberto Caraballo Marcos Semprino Lorena Fasulo Gabriela Reyes Santiago Chac ón Adolfo Gallo Celeste Buompadre Source Type: research

Indirect treatment comparison of cenobamate to other ASMs for the treatment of uncontrolled focal seizures
Epilepsy Behav. 2021 Dec 1;126:108429. doi: 10.1016/j.yebeh.2021.108429. Online ahead of print.ABSTRACTOBJECTIVE: The efficacy and safety of cenobamate relative to other antiseizure medications (ASMs) has not been evaluated. An indirect treatment comparison (network meta-analysis) was performed to determine if adjunctive cenobamate increases the odds ratio (OR) for ≥50% responder rate or for withdrawals due to treatment-emergent adverse events (TEAEs) leading to ASM discontinuation versus adjunctive therapy with other ASMs.METHODS: A systematic literature review was conducted to identify randomized, double-blind, placeb...
Source: Epilepsy and Behaviour - December 5, 2021 Category: Neurology Authors: Michael Privitera Florent F Richy Vernon F Schabert Source Type: research

Epidemiology, healthcare resource use, and mortality in patients with probable Dravet syndrome: A population-based study on German health insurance data
Epilepsy Behav. 2021 Dec 1;126:108442. doi: 10.1016/j.yebeh.2021.108442. Online ahead of print.ABSTRACTOBJECTIVE: Ten-year retrospective study to assess burden of illness in patients with probable Dravet syndrome (DS) identified from German healthcare data.METHODS: In the absence of an International Classification of Diseases code, patients with probable DS were identified using a selection algorithm considering diagnoses and drug prescriptions. Primary analyses were prevalence and demographics; secondary analyses included healthcare costs, annual hospitalization rate (AHR) and length of stay (LOS), medication use, and mor...
Source: Epilepsy and Behaviour - December 5, 2021 Category: Neurology Authors: Susanne Schubert-Bast Lara Kay Andreas Simon Geoffrey Wyatt Rowena Holland Felix Rosenow Adam Strzelczyk Source Type: research

Marital status among patients with epilepsy in Saudi Arabia
Epilepsy Behav. 2021 Dec 1;126:108452. doi: 10.1016/j.yebeh.2021.108452. Online ahead of print.ABSTRACTThere are no adequate studies on Saudi Arabia regarding the effect of the social environment on marriage among people with epilepsy (PWE). To fill this gap in the literature, we investigated the marital status of PWE to determine the factors affecting their marital prospects. The subjects of the study included PWE aged 18 years or above, recruited between 1998 and 2019 from the Epilepsy Registry of King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia. We collected a wide range of socio-demographic dat...
Source: Epilepsy and Behaviour - December 5, 2021 Category: Neurology Authors: Manal Almarzouqi Saleh Alageel Amani Almeharish Abdulaziz Alsemari Source Type: research

Prescription patterns and dosages of antiepileptic drugs in prevalent patients with epilepsy in Taiwan: A nationwide retrospective cross-sectional study
Epilepsy Behav. 2021 Dec 2;126:108450. doi: 10.1016/j.yebeh.2021.108450. Online ahead of print.ABSTRACTOBJECTIVE: To evaluate the prescription patterns and prescribed daily dose (PDD)/defined daily dose (DDD) ratios of antiepileptic drugs (AEDs) in prevalent patients with epilepsy in Taiwan.MATERIALS AND METHODS: A nationwide retrospective cross-sectional study was conducted for prevalent patients with epilepsy in 2016 using the Taiwanese National Health Insurance Research Database. The prescription records of AEDs of all prevalent patients with epilepsy were retrieved. The mean PDDs and PDD/DDD ratios of AEDs in adult pat...
Source: Epilepsy and Behaviour - December 5, 2021 Category: Neurology Authors: Chun-Yu Liang Kuo-Liang Chiang Liang-Po Hsieh Li-Nien Chien Source Type: research

Infantile spasms: Knowledge, attitude, and practice of pediatricians in Turkey
CONCLUSION: Our findings highlight the importance of medical education as awareness is critical for diagnosing ISS. To facilitate rapid diagnosis, it is also important to combine medical education with public action. To ensure a sufficient level of knowledge about epileptic spasms and ISS, a strategy based on the socio-cultural characteristics of each population should be developed.PMID:34864626 | DOI:10.1016/j.yebeh.2021.108456 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - December 5, 2021 Category: Neurology Authors: Deniz Y ılmaz Özlem Yayıcı Köken Esra G ürkaş Nesrin Ceylan Ay şegül Neşe Çıtak Kurt Source Type: research

Psychiatric symptoms are the strongest predictors of quality of life in patients with drug-resistant epilepsy or psychogenic nonepileptic seizures: Authors' response
Epilepsy Behav. 2021 Nov 25:108436. doi: 10.1016/j.yebeh.2021.108436. Online ahead of print.NO ABSTRACTPMID:34840064 | DOI:10.1016/j.yebeh.2021.108436 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - November 29, 2021 Category: Neurology Authors: Charles B Malpas Benjamin Johnstone Dennis Velakoulis Patrick Kwan Terence J O'Brien Source Type: research

Psychiatric symptoms are the strongest predictors of quality of life in patients with drug-resistant epilepsy or psychogenic nonepileptic seizures: Authors' response
Epilepsy Behav. 2021 Nov 25:108436. doi: 10.1016/j.yebeh.2021.108436. Online ahead of print.NO ABSTRACTPMID:34840064 | DOI:10.1016/j.yebeh.2021.108436 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - November 29, 2021 Category: Neurology Authors: Charles B Malpas Benjamin Johnstone Dennis Velakoulis Patrick Kwan Terence J O'Brien Source Type: research

Psychiatric symptoms are the strongest predictors of quality of life in patients with drug-resistant epilepsy or psychogenic nonepileptic seizures: Authors' response
Epilepsy Behav. 2021 Nov 25:108436. doi: 10.1016/j.yebeh.2021.108436. Online ahead of print.NO ABSTRACTPMID:34840064 | DOI:10.1016/j.yebeh.2021.108436 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - November 29, 2021 Category: Neurology Authors: Charles B Malpas Benjamin Johnstone Dennis Velakoulis Patrick Kwan Terence J O'Brien Source Type: research

Psychiatric symptoms are the strongest predictors of quality of life in patients with drug-resistant epilepsy or psychogenic nonepileptic seizures: Authors' response
Epilepsy Behav. 2021 Nov 25:108436. doi: 10.1016/j.yebeh.2021.108436. Online ahead of print.NO ABSTRACTPMID:34840064 | DOI:10.1016/j.yebeh.2021.108436 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - November 29, 2021 Category: Neurology Authors: Charles B Malpas Benjamin Johnstone Dennis Velakoulis Patrick Kwan Terence J O'Brien Source Type: research

Psychiatric symptoms are the strongest predictors of quality of life in patients with drug-resistant epilepsy or psychogenic nonepileptic seizures: Authors' response
Epilepsy Behav. 2021 Nov 25:108436. doi: 10.1016/j.yebeh.2021.108436. Online ahead of print.NO ABSTRACTPMID:34840064 | DOI:10.1016/j.yebeh.2021.108436 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - November 29, 2021 Category: Neurology Authors: Charles B Malpas Benjamin Johnstone Dennis Velakoulis Patrick Kwan Terence J O'Brien Source Type: research

Psychiatric symptoms are the strongest predictors of quality of life in patients with drug-resistant epilepsy or psychogenic nonepileptic seizures: Authors' response
Epilepsy Behav. 2021 Nov 25:108436. doi: 10.1016/j.yebeh.2021.108436. Online ahead of print.NO ABSTRACTPMID:34840064 | DOI:10.1016/j.yebeh.2021.108436 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - November 29, 2021 Category: Neurology Authors: Charles B Malpas Benjamin Johnstone Dennis Velakoulis Patrick Kwan Terence J O'Brien Source Type: research

Survey of the perceived treatment gap in status epilepticus care across Sub-Saharan countries from the perspective of healthcare providers
CONCLUSION: A substantial perceived treatment gap in the management of SE in SSA is identified by staff working in SSA. Key issues are around staff training, patient education, medication access, and compliance.PMID:34839239 | DOI:10.1016/j.yebeh.2021.108408 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - November 28, 2021 Category: Neurology Authors: Christopher Marshall Tolu Olaniyan Alhaji Alusine Jalloh John N Jabang Annet Kirunda Mundih Noelar Njohjam Bankole Murtala Olusola Thomas Z Karway Edward Shabangu Joan Kagema Andrew Malunga Prince Kazadi Millie Kumwenda Michael Kinney Source Type: research

The intellectual profile of pediatric patients with posterior cortex epilepsy
In this study, we investigated the presurgical intellectual profile of children and adolescents with drug-resistant PCE.METHODS: Children and adolescents diagnosed with PCE (n = 25) participated in this study. The data were obtained from medical records, with assessments carried out between the years 2003 and 2019. To compare the intellectual profile, we also included patients diagnosed with frontal (n = 26) and temporal lobe epilepsy (n = 40). The Wechsler Intelligence Scales were used for the assessment of general intelligence.RESULTS: There was an effect of the brain region on the Working Memory Index (p
Source: Epilepsy and Behaviour - November 28, 2021 Category: Neurology Authors: Lucas Emmanuel Lopes E Santos Geisa de Angelis Tonicarlo Rodrigues Velasco Ursula Thome Marcelo Volpon Santos H élio Rubens Machado Ana Paula Andrade Hamad Am érico Ceiki Sakamoto Lauro Wichert-Ana Source Type: research

Sexual and reproductive health concerns of women with epilepsy beginning in adolescence and young adulthood
CONCLUSION: WWE, including nulliparous adolescent and young adult women who are not actively planning pregnancy, have significant concerns about how their epilepsy interacts with SRH. SRH counseling for WWE should begin during adolescence and be incorporated into the transition process from pediatric to adult healthcare. Insights from WWE may aid in the creation of relevant patient-facing educational resources as well as provider-facing training and tools to meaningfully support the reproductive decision-making of WWE throughout their childbearing years.PMID:34839241 | DOI:10.1016/j.yebeh.2021.108439 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - November 28, 2021 Category: Neurology Authors: Laura Kirkpatrick Elizabeth Harrison Sonya Borrero Elizabeth Miller Yoshimi Sogawa Olivia M Stransky Mehret Birru Talabi Alexandra Urban Traci M Kazmerski Source Type: research

Impact of recommendations on sodium valproate prescription among women with epilepsy: An interrupted time-series study
CONCLUSIONS: VPA use decreased over the study period among females with epilepsy but there were still 317 women and 206 girls started on VPA therapy VPA in 2017 (8 per 1000 at-risk and 18 per 1000, respectively). This suggests that either the measures should be strengthened or that the lowest level of VPA use has been reached. In this context, the introduction of a new RMM (in 2018) needs to be evaluated.PMID:34839242 | DOI:10.1016/j.yebeh.2021.108449 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - November 28, 2021 Category: Neurology Authors: Adeline Degremont Elisabeth Polard Sandrine Kerbrat Olivier Grimaud Annie-Pierre Jonville-B éra Virginie Ringa David Travers Emmanuel Oger Arnaud Biraben Emmanuel Nowak Source Type: research

The rescue therapy in epilepsy project Part 2: Insights from people with epilepsy and families on expert-derived preferred practices
Epilepsy Behav. 2021 Nov 25;125:108444. doi: 10.1016/j.yebeh.2021.108444. Online ahead of print.ABSTRACTBACKGROUND: The number and type of therapies available to treat seizure clusters (SCs) or periods of increased seizure activity have risen in recent years. Gaps still exist on defining SCs, when to use them, and educating patients and families. The Epilepsy Foundation developed and published expert-derived consensus on preferred practices for rescue therapies (RTs), 79% of which were agreed upon by a larger group of healthcare professionals (HCPs). This paper describes insights from people with epilepsy (PWE) and familie...
Source: Epilepsy and Behaviour - November 28, 2021 Category: Neurology Authors: Patricia O Shafer Nancy Santilli Jeffrey Buchhalter Brian Gilchrist Alison Kukla Jaqueline A French Lawrence J Hirsch Source Type: research

Patient Health Questionnaire (PHQ-9): A depression screening tool for people with epilepsy in Vietnam
CONCLUSIONS: The Vietnamese version PHQ-9 is an efficient and valid screening tool for depression in people with epilepsy in clinic settings.PMID:34839244 | DOI:10.1016/j.yebeh.2021.108446 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - November 28, 2021 Category: Neurology Authors: Tram Le Hoang Ngoc Minh-An Thuy Le Hung Thien Nguyen Hanh-Vi Vo Ngan Quynh Le Loc Ngoc Phuong Tang Thanh Trung Tran Tuan Van Le Source Type: research

Depression severity mediates the impact of perceived stigma on quality of life in patients with epilepsy
CONCLUSION: This study provided evidence that depression severity mediates the impact that perceived stigma has on quality of life, indicating that assessment of and interventions targeting depression may be appropriate for PWE.PMID:34839245 | DOI:10.1016/j.yebeh.2021.108448 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - November 28, 2021 Category: Neurology Authors: Hanyu Zhang Rui Zhong Qingling Chen Xin Guo Yujian Han Xinyue Zhang Weihong Lin Source Type: research

Epilepsy and the risk of severe coronavirus disease 2019 outcomes: A systematic review, meta-analysis, and meta-regression
CONCLUSIONS: The findings of this study suggest that patients with epilepsy are at risk of having poor COVID-19 outcomes. Patients with epilepsy need special attention and should be prioritized for administration of the COVID-19 vaccine. Registration details: PROSPERO (CRD42021264979).PMID:34839246 | DOI:10.1016/j.yebeh.2021.108437 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - November 28, 2021 Category: Neurology Authors: Yusak Mangara Tua Siahaan Retno Jayantri Ketaren Vinson Hartoyo Timotius Ivan Hariyanto Source Type: research

Differential diagnosis between epileptic and psychogenic nonepileptic seizures through conversational analysis: A blinded prospective study in the Russian language
Epilepsy Behav. 2021 Nov 24;125:108441. doi: 10.1016/j.yebeh.2021.108441. Online ahead of print.ABSTRACTThe current study examined the validity of conversational analysis (CA) in Russian patients with seizures, using a scoring table for the Simplified Linguistic Evaluation (SLE). The study sample was composed of 12 adult participants suffering either from epilepsy (ES) or psychogenic nonepileptic seizures (PNES) recruited in the Moscow Research and Clinical Center for Neuropsychiatry. Definitive diagnosis was established only after a habitual event was captured onvEEG. All participants with PNES or ES and at least one ment...
Source: Epilepsy and Behaviour - November 27, 2021 Category: Neurology Authors: Mikhail Zinchuk Massimiliano Beghi Silvia Diotti Evgenii Pashnin Georgii Kustov Flora Rider Lina Urh Alla Guekht Cesare Maria Cornaggia Source Type: research

Multivariate analysis of the impact of weather and air pollution on emergency department visits for unprovoked seizure among children: A retrospective clinical observational study
CONCLUSIONS: The present study is the first to evaluate the association between the number of children who presented to the ED with nighttime unprovoked seizures and environmental factors after controlling for confounding factors.PMID:34837841 | DOI:10.1016/j.yebeh.2021.108434 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - November 27, 2021 Category: Neurology Authors: Hiroshi Yamaguchi Kandai Nozu Shinya Ishiko Atsushi Kondo Nobuyuki Yamamoto Akihiro Tamura Yuya Aoto Ai Unzaki Kazuto Ishibashi Ichiro Morioka Hiroaki Nagase Akihito Ishida Source Type: research

Different circuitry dysfunction in drug-naive patients with juvenile myoclonic epilepsy and juvenile absence epilepsy
CONCLUSIONS: Our data suggest that regional network changes in alpha and beta bands underlie the different presentation distinguishing JME and JAE resulting in motor vs non-motor seizures characterizing these two syndromes. Conversely, impaired gamma-activity within the network seems to be a non-local marker of defective inhibition.PMID:34837842 | DOI:10.1016/j.yebeh.2021.108443 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - November 27, 2021 Category: Neurology Authors: Laura Canafoglia Ilaria Vigan ò Edoardo Ferlazzo Elisa Visani Tiziana Granata Aglaia Vignoli Francesca Ragona Sara Gasparini Umberto Aguglia Maria Paola Canevini Giulia Varotto Ferruccio Panzica Silvana Franceschetti Source Type: research

Carotid intima-media and epicardial adipose tissue thickness in adult patients with epilepsy taking anti-seizure medication and its long-term significance
CONCLUSION: Anti-seizure medications contribute to accelerated atherosclerosis in people with epilepsy. Chronic use of ASMs may increase this chance. It is appropriate to use ASM(s) with lower chances of atherosclerosis in people with epilepsy and encourage them to change their lifestyle in order to modify cardiovascular risk factors. Meantime, it is reasonable to assess the risk of atherosclerosis periodically in these patients by noninvasive methods including lipid profile, CIMT, and EATT.PMID:34837843 | DOI:10.1016/j.yebeh.2021.108432 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - November 27, 2021 Category: Neurology Authors: Behnam Safarpour Lima Alireza Mohamadzadeh Morvarid Dadras Ali Mahdavi Behnam Mansouri Mohsen Farazdaghi Source Type: research

Audiogenic kindling stimulates aberrant neurogenesis, synaptopodin expression, and mossy fiber sprouting in the hippocampus of rats genetically prone to audiogenic seizures
Epilepsy Behav. 2021 Nov 24;125:108445. doi: 10.1016/j.yebeh.2021.108445. Online ahead of print.ABSTRACTTemporal lobe epilepsy is associated with considerable structural changes in the hippocampus. Pharmacological and electrical models of temporal lobe epilepsy in animals strongly suggest that hippocampal reorganization is based on seizure-stimulated aberrant neurogenesis but the data are often controversial and hard to interpret. The aim of the present study was to estimate neurogenesis and synaptic remodeling in the hippocampus of Krushinsky-Molodkina (KM) rats genetically prone to audiogenic seizures (AGS). In our exper...
Source: Epilepsy and Behaviour - November 27, 2021 Category: Neurology Authors: Alexey A Kulikov Alexandra A Naumova Ekaterina P Aleksandrova Margarita V Glazova Elena V Chernigovskaya Source Type: research

Prevalence of recreational substance use in patients presenting with seizures to a tertiary care hospital
CONCLUSIONS: Overall, the most common concomitantly positively tested RSU during seizure encounters was cannabinoid (40.7%) followed by benzodiazepine (38.7%). There was a higher proportion of males' encounters with concomitant seizure and RSU regardless of type of drug class. Amphetamine use was more common in Caucasians, while the remaining studied RSU were more common in African Americans. Similar trends were seen in the subgroup of subjects older than 16 years.PMID:34837845 | DOI:10.1016/j.yebeh.2021.108419 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - November 27, 2021 Category: Neurology Authors: Parul Goyal Prince Sethi Sameer Sharma Source Type: research

Differential diagnosis between epileptic and psychogenic nonepileptic seizures through conversational analysis: A blinded prospective study in the Russian language
Epilepsy Behav. 2021 Nov 24;125:108441. doi: 10.1016/j.yebeh.2021.108441. Online ahead of print.ABSTRACTThe current study examined the validity of conversational analysis (CA) in Russian patients with seizures, using a scoring table for the Simplified Linguistic Evaluation (SLE). The study sample was composed of 12 adult participants suffering either from epilepsy (ES) or psychogenic nonepileptic seizures (PNES) recruited in the Moscow Research and Clinical Center for Neuropsychiatry. Definitive diagnosis was established only after a habitual event was captured onvEEG. All participants with PNES or ES and at least one ment...
Source: Epilepsy and Behaviour - November 27, 2021 Category: Neurology Authors: Mikhail Zinchuk Massimiliano Beghi Silvia Diotti Evgenii Pashnin Georgii Kustov Flora Rider Lina Urh Alla Guekht Cesare Maria Cornaggia Source Type: research

Multivariate analysis of the impact of weather and air pollution on emergency department visits for unprovoked seizure among children: A retrospective clinical observational study
CONCLUSIONS: The present study is the first to evaluate the association between the number of children who presented to the ED with nighttime unprovoked seizures and environmental factors after controlling for confounding factors.PMID:34837841 | DOI:10.1016/j.yebeh.2021.108434 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - November 27, 2021 Category: Neurology Authors: Hiroshi Yamaguchi Kandai Nozu Shinya Ishiko Atsushi Kondo Nobuyuki Yamamoto Akihiro Tamura Yuya Aoto Ai Unzaki Kazuto Ishibashi Ichiro Morioka Hiroaki Nagase Akihito Ishida Source Type: research

Different circuitry dysfunction in drug-naive patients with juvenile myoclonic epilepsy and juvenile absence epilepsy
CONCLUSIONS: Our data suggest that regional network changes in alpha and beta bands underlie the different presentation distinguishing JME and JAE resulting in motor vs non-motor seizures characterizing these two syndromes. Conversely, impaired gamma-activity within the network seems to be a non-local marker of defective inhibition.PMID:34837842 | DOI:10.1016/j.yebeh.2021.108443 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - November 27, 2021 Category: Neurology Authors: Laura Canafoglia Ilaria Vigan ò Edoardo Ferlazzo Elisa Visani Tiziana Granata Aglaia Vignoli Francesca Ragona Sara Gasparini Umberto Aguglia Maria Paola Canevini Giulia Varotto Ferruccio Panzica Silvana Franceschetti Source Type: research

Carotid intima-media and epicardial adipose tissue thickness in adult patients with epilepsy taking anti-seizure medication and its long-term significance
CONCLUSION: Anti-seizure medications contribute to accelerated atherosclerosis in people with epilepsy. Chronic use of ASMs may increase this chance. It is appropriate to use ASM(s) with lower chances of atherosclerosis in people with epilepsy and encourage them to change their lifestyle in order to modify cardiovascular risk factors. Meantime, it is reasonable to assess the risk of atherosclerosis periodically in these patients by noninvasive methods including lipid profile, CIMT, and EATT.PMID:34837843 | DOI:10.1016/j.yebeh.2021.108432 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - November 27, 2021 Category: Neurology Authors: Behnam Safarpour Lima Alireza Mohamadzadeh Morvarid Dadras Ali Mahdavi Behnam Mansouri Mohsen Farazdaghi Source Type: research

Audiogenic kindling stimulates aberrant neurogenesis, synaptopodin expression, and mossy fiber sprouting in the hippocampus of rats genetically prone to audiogenic seizures
Epilepsy Behav. 2021 Nov 24;125:108445. doi: 10.1016/j.yebeh.2021.108445. Online ahead of print.ABSTRACTTemporal lobe epilepsy is associated with considerable structural changes in the hippocampus. Pharmacological and electrical models of temporal lobe epilepsy in animals strongly suggest that hippocampal reorganization is based on seizure-stimulated aberrant neurogenesis but the data are often controversial and hard to interpret. The aim of the present study was to estimate neurogenesis and synaptic remodeling in the hippocampus of Krushinsky-Molodkina (KM) rats genetically prone to audiogenic seizures (AGS). In our exper...
Source: Epilepsy and Behaviour - November 27, 2021 Category: Neurology Authors: Alexey A Kulikov Alexandra A Naumova Ekaterina P Aleksandrova Margarita V Glazova Elena V Chernigovskaya Source Type: research

Prevalence of recreational substance use in patients presenting with seizures to a tertiary care hospital
CONCLUSIONS: Overall, the most common concomitantly positively tested RSU during seizure encounters was cannabinoid (40.7%) followed by benzodiazepine (38.7%). There was a higher proportion of males' encounters with concomitant seizure and RSU regardless of type of drug class. Amphetamine use was more common in Caucasians, while the remaining studied RSU were more common in African Americans. Similar trends were seen in the subgroup of subjects older than 16 years.PMID:34837845 | DOI:10.1016/j.yebeh.2021.108419 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - November 27, 2021 Category: Neurology Authors: Parul Goyal Prince Sethi Sameer Sharma Source Type: research

Effectiveness of lacosamide in children and young adults previously treated with other sodium channel blockers
Epilepsy Behav. 2021 Nov 20;125:108397. doi: 10.1016/j.yebeh.2021.108397. Online ahead of print.ABSTRACTPURPOSE: This multicenter study examined the effectiveness and tolerability of lacosamide (LCM) for children and young adults with epilepsy, particularly in patients who had previously been treated with other sodium channel blockers (SCBs) and the difference in effectiveness and tolerability when using other concomitant SCBs.METHODS: We retrospectively studied the clinical information of patients aged
Source: Epilepsy and Behaviour - November 23, 2021 Category: Neurology Authors: Takeshi Suzuki Jun Natsume Sumire Kumai Yuki Maki Hiroyuki Yamamoto Shingo Numoto Sho Narahara Tetsuo Kubota Takeshi Tsuji Toru Kato Keitaro Yamada Koichi Maruyama Akihisa Okumura Yoshiyuki Takahashi Hiroyuki Kidokoro Source Type: research

Effectiveness of lacosamide in children and young adults previously treated with other sodium channel blockers
Epilepsy Behav. 2021 Nov 20;125:108397. doi: 10.1016/j.yebeh.2021.108397. Online ahead of print.ABSTRACTPURPOSE: This multicenter study examined the effectiveness and tolerability of lacosamide (LCM) for children and young adults with epilepsy, particularly in patients who had previously been treated with other sodium channel blockers (SCBs) and the difference in effectiveness and tolerability when using other concomitant SCBs.METHODS: We retrospectively studied the clinical information of patients aged
Source: Epilepsy and Behaviour - November 23, 2021 Category: Neurology Authors: Takeshi Suzuki Jun Natsume Sumire Kumai Yuki Maki Hiroyuki Yamamoto Shingo Numoto Sho Narahara Tetsuo Kubota Takeshi Tsuji Toru Kato Keitaro Yamada Koichi Maruyama Akihisa Okumura Yoshiyuki Takahashi Hiroyuki Kidokoro Source Type: research

Effectiveness of lacosamide in children and young adults previously treated with other sodium channel blockers
Epilepsy Behav. 2021 Nov 20;125:108397. doi: 10.1016/j.yebeh.2021.108397. Online ahead of print.ABSTRACTPURPOSE: This multicenter study examined the effectiveness and tolerability of lacosamide (LCM) for children and young adults with epilepsy, particularly in patients who had previously been treated with other sodium channel blockers (SCBs) and the difference in effectiveness and tolerability when using other concomitant SCBs.METHODS: We retrospectively studied the clinical information of patients aged
Source: Epilepsy and Behaviour - November 23, 2021 Category: Neurology Authors: Takeshi Suzuki Jun Natsume Sumire Kumai Yuki Maki Hiroyuki Yamamoto Shingo Numoto Sho Narahara Tetsuo Kubota Takeshi Tsuji Toru Kato Keitaro Yamada Koichi Maruyama Akihisa Okumura Yoshiyuki Takahashi Hiroyuki Kidokoro Source Type: research

Cortical regions and networks of hyperkinetic seizures: Electrocorticography and diffusion tensor imaging study
CONCLUSION: The present results suggest the cortical areas (the inferior parietal lobule, temporo-occipital junction, medial temporal area, and medial/lateral frontal lobe) and subcortical fibers (IFOF, ILF, MLF, AF/SLFII, III, and the cingulum bundle) responsible for generating hyperkinetic seizures.PMID:34801803 | DOI:10.1016/j.yebeh.2021.108405 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - November 21, 2021 Category: Neurology Authors: Ayaka Sasagawa Rei Enatsu Tomoyoshi Kuribara Masayasu Arihara Tsukasa Hirano Satoko Ochi Nobuhiro Mikuni Source Type: research

Cortical regions and networks of hyperkinetic seizures: Electrocorticography and diffusion tensor imaging study
CONCLUSION: The present results suggest the cortical areas (the inferior parietal lobule, temporo-occipital junction, medial temporal area, and medial/lateral frontal lobe) and subcortical fibers (IFOF, ILF, MLF, AF/SLFII, III, and the cingulum bundle) responsible for generating hyperkinetic seizures.PMID:34801803 | DOI:10.1016/j.yebeh.2021.108405 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - November 21, 2021 Category: Neurology Authors: Ayaka Sasagawa Rei Enatsu Tomoyoshi Kuribara Masayasu Arihara Tsukasa Hirano Satoko Ochi Nobuhiro Mikuni Source Type: research

Cortical regions and networks of hyperkinetic seizures: Electrocorticography and diffusion tensor imaging study
CONCLUSION: The present results suggest the cortical areas (the inferior parietal lobule, temporo-occipital junction, medial temporal area, and medial/lateral frontal lobe) and subcortical fibers (IFOF, ILF, MLF, AF/SLFII, III, and the cingulum bundle) responsible for generating hyperkinetic seizures.PMID:34801803 | DOI:10.1016/j.yebeh.2021.108405 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - November 21, 2021 Category: Neurology Authors: Ayaka Sasagawa Rei Enatsu Tomoyoshi Kuribara Masayasu Arihara Tsukasa Hirano Satoko Ochi Nobuhiro Mikuni Source Type: research