The perceived effects of cannabis products in the management of seizures in CDKL5 Deficiency Disorder
CONCLUSIONS: Although this is an observational study, limited by potential participation bias and the unreliable nature of unblinded self-assessment, it suggests that caregivers perceive cannabis products, especially cannabidiol, to have a tolerable adverse effect profile and adequate efficacy. Despite this, cannabis was not associated with a reduction in seizure frequency nor number of antiepileptic drugs when compared to non-users or when compared to pre-treatment. Randomized controlled trials are urgently needed to more reliably assess this treatment's safety and efficacy.PMID:34148781 | DOI:10.1016/j.yebeh.2021.108152 ...
Source: Epilepsy and Behaviour - June 21, 2021 Category: Neurology Authors: Tristan Dale Jenny Downs Kingsley Wong Helen Leonard Source Type: research

Neural networks underlying hyperkinetic seizures: A quantitative PET and SEEG study
Epilepsy Behav. 2021 Jun 18;122:108130. doi: 10.1016/j.yebeh.2021.108130. Online ahead of print.ABSTRACTOBJECTIVE: Hyperkinetic seizures (HKS) are characterized by complex movements that commonly occur during seizures arising from diverse cortical structures. A common semiology network may exist and analyzing the anatomo-electrical mechanisms would facilitate presurgical evaluation. Here, quantitative positron emission tomography (PET) and stereoelectroencephalography (SEEG) analysis was used to explore the underlying mechanism of HKS.METHODS: We retrospectively collected patients with epilepsy with HKS between 2014 and 20...
Source: Epilepsy and Behaviour - June 21, 2021 Category: Neurology Authors: Xiu Wang Wen-Han Hu Chao Zhang Xiao-Qiu Shao Lin Sang Zhong Zheng Yao Wang Bao-Tian Zhao Dong-Mei Gao Jia-Jie Mo Jian-Guo Zhang Kai Zhang Source Type: research

The co-occurrence of dementia in those with epilepsy is associated with 30-day readmission - A population-based study
Epilepsy Behav. 2021 Jun 18;122:108126. doi: 10.1016/j.yebeh.2021.108126. Online ahead of print.ABSTRACTOBJECTIVE: Dementia and epilepsy often co-occur and are associated with poor health outcomes and increased healthcare utilization. The literature on the association between readmission and co-occurrence of dementia and epilepsy is scant. Our objective was to determine if dementia in patients with epilepsy>40 years old is associated with 30-day hospital readmission, in-hospital mortality, discharge disposition, and length-of-stay.METHODS: This retrospective cohort study used the 2014 Nationwide Readmissions Database, c...
Source: Epilepsy and Behaviour - June 21, 2021 Category: Neurology Authors: Helaina Lehrer Jung-Yi Lin Churl-Su Kwon Parul Agarwal Madhu Mazumdar Nathalie Jett é Source Type: research

Blood oxygen level-dependent (BOLD) response patterns with thalamic deep brain stimulation in patients with medically refractory epilepsy
Epilepsy Behav. 2021 Jun 18;122:108153. doi: 10.1016/j.yebeh.2021.108153. Online ahead of print.ABSTRACTOBJECTIVE: Anterior nucleus of thalamus (ANT) deep brain stimulation (DBS) has shown promise as a treatment for medically refractory epilepsy. To better understand the mechanism of this intervention, we used functional magnetic resonance imaging (fMRI) to map the acute blood oxygen level-dependent (BOLD) response pattern to thalamic DBS in fully implanted patients with epilepsy.METHODS: Two patients with epilepsy implanted with bilateral ANT-DBS devices underwent four fMRI acquisitions each, during which active left-side...
Source: Epilepsy and Behaviour - June 21, 2021 Category: Neurology Authors: Can Sarica Kazuaki Yamamoto Aaron Loh Gavin J B Elias Alexandre Boutet Radhika Madhavan J ürgen Germann Ajmal Zemmar Dave Gwun Jordy Tasserie Danielle M Andrade Mojgan Hodaie Suneil K Kalia Richard A Wennberg Andres M Lozano Source Type: research

The perceived effects of cannabis products in the management of seizures in CDKL5 Deficiency Disorder
CONCLUSIONS: Although this is an observational study, limited by potential participation bias and the unreliable nature of unblinded self-assessment, it suggests that caregivers perceive cannabis products, especially cannabidiol, to have a tolerable adverse effect profile and adequate efficacy. Despite this, cannabis was not associated with a reduction in seizure frequency nor number of antiepileptic drugs when compared to non-users or when compared to pre-treatment. Randomized controlled trials are urgently needed to more reliably assess this treatment's safety and efficacy.PMID:34148781 | DOI:10.1016/j.yebeh.2021.108152 ...
Source: Epilepsy and Behaviour - June 21, 2021 Category: Neurology Authors: Tristan Dale Jenny Downs Kingsley Wong Helen Leonard Source Type: research

Neural networks underlying hyperkinetic seizures: A quantitative PET and SEEG study
Epilepsy Behav. 2021 Jun 18;122:108130. doi: 10.1016/j.yebeh.2021.108130. Online ahead of print.ABSTRACTOBJECTIVE: Hyperkinetic seizures (HKS) are characterized by complex movements that commonly occur during seizures arising from diverse cortical structures. A common semiology network may exist and analyzing the anatomo-electrical mechanisms would facilitate presurgical evaluation. Here, quantitative positron emission tomography (PET) and stereoelectroencephalography (SEEG) analysis was used to explore the underlying mechanism of HKS.METHODS: We retrospectively collected patients with epilepsy with HKS between 2014 and 20...
Source: Epilepsy and Behaviour - June 21, 2021 Category: Neurology Authors: Xiu Wang Wen-Han Hu Chao Zhang Xiao-Qiu Shao Lin Sang Zhong Zheng Yao Wang Bao-Tian Zhao Dong-Mei Gao Jia-Jie Mo Jian-Guo Zhang Kai Zhang Source Type: research

The co-occurrence of dementia in those with epilepsy is associated with 30-day readmission - A population-based study
Epilepsy Behav. 2021 Jun 18;122:108126. doi: 10.1016/j.yebeh.2021.108126. Online ahead of print.ABSTRACTOBJECTIVE: Dementia and epilepsy often co-occur and are associated with poor health outcomes and increased healthcare utilization. The literature on the association between readmission and co-occurrence of dementia and epilepsy is scant. Our objective was to determine if dementia in patients with epilepsy>40 years old is associated with 30-day hospital readmission, in-hospital mortality, discharge disposition, and length-of-stay.METHODS: This retrospective cohort study used the 2014 Nationwide Readmissions Database, c...
Source: Epilepsy and Behaviour - June 21, 2021 Category: Neurology Authors: Helaina Lehrer Jung-Yi Lin Churl-Su Kwon Parul Agarwal Madhu Mazumdar Nathalie Jett é Source Type: research

Blood oxygen level-dependent (BOLD) response patterns with thalamic deep brain stimulation in patients with medically refractory epilepsy
Epilepsy Behav. 2021 Jun 18;122:108153. doi: 10.1016/j.yebeh.2021.108153. Online ahead of print.ABSTRACTOBJECTIVE: Anterior nucleus of thalamus (ANT) deep brain stimulation (DBS) has shown promise as a treatment for medically refractory epilepsy. To better understand the mechanism of this intervention, we used functional magnetic resonance imaging (fMRI) to map the acute blood oxygen level-dependent (BOLD) response pattern to thalamic DBS in fully implanted patients with epilepsy.METHODS: Two patients with epilepsy implanted with bilateral ANT-DBS devices underwent four fMRI acquisitions each, during which active left-side...
Source: Epilepsy and Behaviour - June 21, 2021 Category: Neurology Authors: Can Sarica Kazuaki Yamamoto Aaron Loh Gavin J B Elias Alexandre Boutet Radhika Madhavan J ürgen Germann Ajmal Zemmar Dave Gwun Jordy Tasserie Danielle M Andrade Mojgan Hodaie Suneil K Kalia Richard A Wennberg Andres M Lozano Source Type: research

Epilepsy & amp; gambling: Risk factors for problem gambling behaviors in people with epilepsy
CONCLUSIONS: People with FLE may have a heightened vulnerability to developing problem gambling behaviors. The role of the neurological consultation in managing these risks is discussed.PMID:34147882 | DOI:10.1016/j.yebeh.2021.108082 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - June 20, 2021 Category: Neurology Authors: Dominic Heaney Sallie Baxendale Source Type: research

Epilepsy & amp; gambling: Risk factors for problem gambling behaviors in people with epilepsy
CONCLUSIONS: People with FLE may have a heightened vulnerability to developing problem gambling behaviors. The role of the neurological consultation in managing these risks is discussed.PMID:34147882 | DOI:10.1016/j.yebeh.2021.108082 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - June 20, 2021 Category: Neurology Authors: Dominic Heaney Sallie Baxendale Source Type: research

Relationship between sleep quality and cognitive performance in patients with epilepsy
Epilepsy Behav. 2021 Jun 16;122:108127. doi: 10.1016/j.yebeh.2021.108127. Online ahead of print.ABSTRACTPURPOSE: To investigate the relationship between self-reported sleep quality and cognitive function in patients with epilepsy (PWE), as well as anxiety and depressive symptoms and patient quality of life (QoL).METHODS: This multicenter cross-sectional study included PWE aged ≥12 years who were receiving ≥1 anti-seizure medication (ASM) and had not been diagnosed with a sleep disorder. Patients completed the Pittsburgh Sleep Quality Index (PSQI), the Epworth Sleepiness Scale (ESS), the Montreal Cognitive Assessment ...
Source: Epilepsy and Behaviour - June 19, 2021 Category: Neurology Authors: Elena Fonseca Dulce M Campos Blanco Mar ía Dolores Castro Vilanova Íñigo Garamendi Mar ía Gómez-Eguilaz Hernando P érez Díaz Juan Jos é Poza Mar ía Rosa Querol-Pascual Pablo Quiroga-Subirana Xiana Rodr íguez-Osorio Jorge Zurita Santamar ía Mar Source Type: research

Cardiac-based detection of seizures in children with epilepsy
CONCLUSION: Our data suggest that cardiac measures can detect seizures with bilateral motor features with high sensitivity, while detection of focal seizures depends on seizure duration and localization and may require customization of parameter thresholds.PMID:34147021 | DOI:10.1016/j.yebeh.2021.108129 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - June 19, 2021 Category: Neurology Authors: Meghan Hegarty-Craver Barbara L Kroner Adrian Bumbut Samuel J DeFilipp William D Gaillard Kristin H Gilchrist Source Type: research

Improved ictal assessment performance in the epilepsy monitoring unit via standardization
CONCLUSIONS: Utilization of a standardized ictal testing battery in conjunction with staff education leads to an objective improvement in ictal assessment performance. Further research is warranted to assess the replicability of our findings.PMID:34147022 | DOI:10.1016/j.yebeh.2021.108067 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - June 19, 2021 Category: Neurology Authors: Brian Hanrahan Robert A Gross Thomas Wychowski Giuseppe Erba Gretchen L Birbeck Lynn Liu Source Type: research

Trigger, risk factor, and self-organizing criticality - One more piece of the puzzle to explain increased mortality in epilepsy?
Epilepsy Behav. 2021 Jun 15;122:108123. doi: 10.1016/j.yebeh.2021.108123. Online ahead of print.NO ABSTRACTPMID:34144457 | DOI:10.1016/j.yebeh.2021.108123 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - June 18, 2021 Category: Neurology Authors: Guilherme L Fialho Peter Wolf Roger Walz Katia Lin Source Type: research

Headaches provoked by cortical stimulation: Their localizing value in focal epileptic seizures
CONCLUSION: This study shows that cortical stimulation can evoke headache, mostly during stimulation of the temporo-frontal limbic regions. It suggests that brief epileptic headache can be an epileptic symptom caused by a cortical discharge involving somatic or visceral network and does not reflect only trigemino-vascular activation. Although not specific, the occurrence of a brief epileptic headache may point to a seizure origin in the temporo-frontal limbic regions.PMID:34144458 | DOI:10.1016/j.yebeh.2021.108125 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - June 18, 2021 Category: Neurology Authors: Eloise Hotolean Laure Mazzola Sylvain Rheims Jean Isnard Alexandra Montavont Helene Catenoix Fran çois Mauguière Genevieve Demarquay Source Type: research

Epilepsy at the intersection of disability, gender, and culture: A duoethnography
Epilepsy Behav. 2021 Jun 15;122:108121. doi: 10.1016/j.yebeh.2021.108121. Online ahead of print.ABSTRACTEpilepsy is a neurodevelopmental disorder that affects millions of adults and children. Several different types of seizures, ranging from generalized which affect both sides of the brain to focal seizures that are rooted in one location of the brain. In addition to the physical impact of epilepsy, there are many emotional and identity consequences of living with epilepsy. An area that is not yet explored is the impact of epilepsy on the lives of women of color. In this paper, we fill this gap by exploring the experiences...
Source: Epilepsy and Behaviour - June 18, 2021 Category: Neurology Authors: Kristina Lopez Yue Xu Source Type: research

Anxiety of families after first unprovoked or first febrile seizure - A prospective, randomized pilot study
Epilepsy Behav. 2021 Jun 15;122:108120. doi: 10.1016/j.yebeh.2021.108120. Online ahead of print.ABSTRACTOBJECTIVES: Parents of children with a first unprovoked seizure report high levels of stress and anxiety. Little is known however about interventions that might help to reduce anxiety. We aimed to evaluate anxiety of parents and children after a first unprovoked seizure and assess the anxiety-reducing effect of a semi-structured follow-up in a first seizure clinic (FSC). In comparison, parents of children with febrile seizures are also evaluated, as an example of anxiety evolution without follow-up intervention after pro...
Source: Epilepsy and Behaviour - June 18, 2021 Category: Neurology Authors: Kerstin Alexandra Klotz Jasmin Özcan Yusuf Sag Jan Sch önberger Klaus Kaier Julia Jacobs Source Type: research

COVID-19 and epilepsy: How are people with epilepsy in Brazil?
CONCLUSION: During COVID-19 pandemic in Brazil, PWE and caregivers reported increase in seizures in one-fourth of the patients and several difficulties, namely problems in accessing the healthcare system including ASM dispensation, telehealth, and fear of having a more severe COVID-19 because of epilepsy. There were also physical, psychological, and social concerns which affected quality-of-life-related aspects in this population. These facts may increase treatment gap in epilepsy in Brazil as well in other developing countries.PMID:34144461 | DOI:10.1016/j.yebeh.2021.108115 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - June 18, 2021 Category: Neurology Authors: Laura Maria Guilhoto Amanda Cristina Mosini Maria Alice Susemihl L écio Figueira Pinto Source Type: research

Toward individualized prediction of seizure recurrence: Hippocampal neuroimaging features in a cohort of patients from a first seizure clinic
CONCLUSION: We propose a prospective, multicenter study to develop and test models for the prediction of seizure recurrence in patients after a first seizure, based on hippocampal neuroimaging. Further longitudinal neuroimaging studies in patients with a first seizure and new-onset epilepsy may provide clues to the microstructural changes occurring at the earliest stages of epilepsy and yield biomarkers of epileptogenesis.PMID:34144462 | DOI:10.1016/j.yebeh.2021.108118 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - June 18, 2021 Category: Neurology Authors: Matthias H Schmidt Candice E Crocker Mohamed Abdolell Mandeep S Ghuman Bernd Pohlmann-Eden Source Type: research

Trigger, risk factor, and self-organizing criticality - One more piece of the puzzle to explain increased mortality in epilepsy?
Epilepsy Behav. 2021 Jun 15;122:108123. doi: 10.1016/j.yebeh.2021.108123. Online ahead of print.NO ABSTRACTPMID:34144457 | DOI:10.1016/j.yebeh.2021.108123 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - June 18, 2021 Category: Neurology Authors: Guilherme L Fialho Peter Wolf Roger Walz Katia Lin Source Type: research

Headaches provoked by cortical stimulation: Their localizing value in focal epileptic seizures
CONCLUSION: This study shows that cortical stimulation can evoke headache, mostly during stimulation of the temporo-frontal limbic regions. It suggests that brief epileptic headache can be an epileptic symptom caused by a cortical discharge involving somatic or visceral network and does not reflect only trigemino-vascular activation. Although not specific, the occurrence of a brief epileptic headache may point to a seizure origin in the temporo-frontal limbic regions.PMID:34144458 | DOI:10.1016/j.yebeh.2021.108125 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - June 18, 2021 Category: Neurology Authors: Eloise Hotolean Laure Mazzola Sylvain Rheims Jean Isnard Alexandra Montavont Helene Catenoix Fran çois Mauguière Genevieve Demarquay Source Type: research

Epilepsy at the intersection of disability, gender, and culture: A duoethnography
Epilepsy Behav. 2021 Jun 15;122:108121. doi: 10.1016/j.yebeh.2021.108121. Online ahead of print.ABSTRACTEpilepsy is a neurodevelopmental disorder that affects millions of adults and children. Several different types of seizures, ranging from generalized which affect both sides of the brain to focal seizures that are rooted in one location of the brain. In addition to the physical impact of epilepsy, there are many emotional and identity consequences of living with epilepsy. An area that is not yet explored is the impact of epilepsy on the lives of women of color. In this paper, we fill this gap by exploring the experiences...
Source: Epilepsy and Behaviour - June 18, 2021 Category: Neurology Authors: Kristina Lopez Yue Xu Source Type: research

Anxiety of families after first unprovoked or first febrile seizure - A prospective, randomized pilot study
Epilepsy Behav. 2021 Jun 15;122:108120. doi: 10.1016/j.yebeh.2021.108120. Online ahead of print.ABSTRACTOBJECTIVES: Parents of children with a first unprovoked seizure report high levels of stress and anxiety. Little is known however about interventions that might help to reduce anxiety. We aimed to evaluate anxiety of parents and children after a first unprovoked seizure and assess the anxiety-reducing effect of a semi-structured follow-up in a first seizure clinic (FSC). In comparison, parents of children with febrile seizures are also evaluated, as an example of anxiety evolution without follow-up intervention after pro...
Source: Epilepsy and Behaviour - June 18, 2021 Category: Neurology Authors: Kerstin Alexandra Klotz Jasmin Özcan Yusuf Sag Jan Sch önberger Klaus Kaier Julia Jacobs Source Type: research

COVID-19 and epilepsy: How are people with epilepsy in Brazil?
CONCLUSION: During COVID-19 pandemic in Brazil, PWE and caregivers reported increase in seizures in one-fourth of the patients and several difficulties, namely problems in accessing the healthcare system including ASM dispensation, telehealth, and fear of having a more severe COVID-19 because of epilepsy. There were also physical, psychological, and social concerns which affected quality-of-life-related aspects in this population. These facts may increase treatment gap in epilepsy in Brazil as well in other developing countries.PMID:34144461 | DOI:10.1016/j.yebeh.2021.108115 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - June 18, 2021 Category: Neurology Authors: Laura Maria Guilhoto Amanda Cristina Mosini Maria Alice Susemihl L écio Figueira Pinto Source Type: research

Toward individualized prediction of seizure recurrence: Hippocampal neuroimaging features in a cohort of patients from a first seizure clinic
CONCLUSION: We propose a prospective, multicenter study to develop and test models for the prediction of seizure recurrence in patients after a first seizure, based on hippocampal neuroimaging. Further longitudinal neuroimaging studies in patients with a first seizure and new-onset epilepsy may provide clues to the microstructural changes occurring at the earliest stages of epilepsy and yield biomarkers of epileptogenesis.PMID:34144462 | DOI:10.1016/j.yebeh.2021.108118 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - June 18, 2021 Category: Neurology Authors: Matthias H Schmidt Candice E Crocker Mohamed Abdolell Mandeep S Ghuman Bernd Pohlmann-Eden Source Type: research

High-frequency monitoring of personalized psychological variables during outpatient psychotherapy in people with seizures: An uncontrolled feasibility study
CONCLUSION: The results support the feasibility of high-frequency monitoring of personalized psychological processes during outpatient psychotherapy. Repeated daily assessments of a personalized questionnaire yield highly resolved, equidistant time series data, which gives insight into individual psychological processes during outpatient psychotherapy.PMID:34139618 | DOI:10.1016/j.yebeh.2021.108119 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - June 17, 2021 Category: Neurology Authors: Rosa Michaelis Friedrich Edelh äuser Yvonne H ülsner Eugen Trinka Kathrin Viol G ünter Schiepek Source Type: research

Electrically stimulated auras as a potential biomarker of the epileptogenic zone
Epilepsy Behav. 2021 Jun 14;122:108116. doi: 10.1016/j.yebeh.2021.108116. Online ahead of print.ABSTRACTElectrocortical stimulation mapping (ESM) is often performed in patients undergoing stereoelectroencephalography (SEEG) prior to epilepsy surgery, with the goal of identifying functional cortex and preserving it postoperatively. ESM may also evoke a patient's typical seizure semiology. The purpose of this study was to determine whether the sites at which typical auras are evoked during ESM are associated with other known clinical and electrophysiologic biomarkers of the epileptogenic zone: the seizure onset zone (SOZ), t...
Source: Epilepsy and Behaviour - June 17, 2021 Category: Neurology Authors: Anna M Bank Santoshi Billakota Lisa M Bateman Marla J Hamberger Jeffrey Cole Guy M McKhann Neil Feldstein Catherine A Schevon Source Type: research

High-frequency monitoring of personalized psychological variables during outpatient psychotherapy in people with seizures: An uncontrolled feasibility study
CONCLUSION: The results support the feasibility of high-frequency monitoring of personalized psychological processes during outpatient psychotherapy. Repeated daily assessments of a personalized questionnaire yield highly resolved, equidistant time series data, which gives insight into individual psychological processes during outpatient psychotherapy.PMID:34139618 | DOI:10.1016/j.yebeh.2021.108119 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - June 17, 2021 Category: Neurology Authors: Rosa Michaelis Friedrich Edelh äuser Yvonne H ülsner Eugen Trinka Kathrin Viol G ünter Schiepek Source Type: research

Electrically stimulated auras as a potential biomarker of the epileptogenic zone
Epilepsy Behav. 2021 Jun 14;122:108116. doi: 10.1016/j.yebeh.2021.108116. Online ahead of print.ABSTRACTElectrocortical stimulation mapping (ESM) is often performed in patients undergoing stereoelectroencephalography (SEEG) prior to epilepsy surgery, with the goal of identifying functional cortex and preserving it postoperatively. ESM may also evoke a patient's typical seizure semiology. The purpose of this study was to determine whether the sites at which typical auras are evoked during ESM are associated with other known clinical and electrophysiologic biomarkers of the epileptogenic zone: the seizure onset zone (SOZ), t...
Source: Epilepsy and Behaviour - June 17, 2021 Category: Neurology Authors: Anna M Bank Santoshi Billakota Lisa M Bateman Marla J Hamberger Jeffrey Cole Guy M McKhann Neil Feldstein Catherine A Schevon Source Type: research

Regulation of TWIK-related K < sup > + < /sup > channel 1 in the anterior hippocampus of patients with temporal lobe epilepsy with comorbid depression
Epilepsy Behav. 2021 Jun 8;121(Pt A):108045. doi: 10.1016/j.yebeh.2021.108045. Online ahead of print.ABSTRACTEpilepsy with comorbid depression has recently attracted increasing attention. Temporal lobe epilepsy (TLE) may represent an increased risk of developing depression, especially if the seizures do not generalize. The two-pore domain potassium channel-TWIK-related K+ channel (TREK-1) plays important roles in both epilepsy and depression. However, the changes in its expression in patients with epilepsy with comorbid depression remain unclear. In the present study, we analyzed depressive symptoms using neuropsychiatric ...
Source: Epilepsy and Behaviour - June 11, 2021 Category: Neurology Authors: Xiao-Li Li Chong-Yang Tang Shu Wang Meng Zhao Xiong-Fei Wang Tian-Fu Li Xue-Ling Qi Guo-Ming Luan Yu-Guang Guan Source Type: research

Regulation of TWIK-related K < sup > + < /sup > channel 1 in the anterior hippocampus of patients with temporal lobe epilepsy with comorbid depression
Epilepsy Behav. 2021 Jun 8;121(Pt A):108045. doi: 10.1016/j.yebeh.2021.108045. Online ahead of print.ABSTRACTEpilepsy with comorbid depression has recently attracted increasing attention. Temporal lobe epilepsy (TLE) may represent an increased risk of developing depression, especially if the seizures do not generalize. The two-pore domain potassium channel-TWIK-related K+ channel (TREK-1) plays important roles in both epilepsy and depression. However, the changes in its expression in patients with epilepsy with comorbid depression remain unclear. In the present study, we analyzed depressive symptoms using neuropsychiatric ...
Source: Epilepsy and Behaviour - June 11, 2021 Category: Neurology Authors: Xiao-Li Li Chong-Yang Tang Shu Wang Meng Zhao Xiong-Fei Wang Tian-Fu Li Xue-Ling Qi Guo-Ming Luan Yu-Guang Guan Source Type: research

Regulation of TWIK-related K < sup > + < /sup > channel 1 in the anterior hippocampus of patients with temporal lobe epilepsy with comorbid depression
Epilepsy Behav. 2021 Jun 8;121(Pt A):108045. doi: 10.1016/j.yebeh.2021.108045. Online ahead of print.ABSTRACTEpilepsy with comorbid depression has recently attracted increasing attention. Temporal lobe epilepsy (TLE) may represent an increased risk of developing depression, especially if the seizures do not generalize. The two-pore domain potassium channel-TWIK-related K+ channel (TREK-1) plays important roles in both epilepsy and depression. However, the changes in its expression in patients with epilepsy with comorbid depression remain unclear. In the present study, we analyzed depressive symptoms using neuropsychiatric ...
Source: Epilepsy and Behaviour - June 11, 2021 Category: Neurology Authors: Xiao-Li Li Chong-Yang Tang Shu Wang Meng Zhao Xiong-Fei Wang Tian-Fu Li Xue-Ling Qi Guo-Ming Luan Yu-Guang Guan Source Type: research

Regulation of TWIK-related K < sup > + < /sup > channel 1 in the anterior hippocampus of patients with temporal lobe epilepsy with comorbid depression
Epilepsy Behav. 2021 Jun 8;121(Pt A):108045. doi: 10.1016/j.yebeh.2021.108045. Online ahead of print.ABSTRACTEpilepsy with comorbid depression has recently attracted increasing attention. Temporal lobe epilepsy (TLE) may represent an increased risk of developing depression, especially if the seizures do not generalize. The two-pore domain potassium channel-TWIK-related K+ channel (TREK-1) plays important roles in both epilepsy and depression. However, the changes in its expression in patients with epilepsy with comorbid depression remain unclear. In the present study, we analyzed depressive symptoms using neuropsychiatric ...
Source: Epilepsy and Behaviour - June 11, 2021 Category: Neurology Authors: Xiao-Li Li Chong-Yang Tang Shu Wang Meng Zhao Xiong-Fei Wang Tian-Fu Li Xue-Ling Qi Guo-Ming Luan Yu-Guang Guan Source Type: research

Regulation of TWIK-related K < sup > + < /sup > channel 1 in the anterior hippocampus of patients with temporal lobe epilepsy with comorbid depression
Epilepsy Behav. 2021 Jun 8;121(Pt A):108045. doi: 10.1016/j.yebeh.2021.108045. Online ahead of print.ABSTRACTEpilepsy with comorbid depression has recently attracted increasing attention. Temporal lobe epilepsy (TLE) may represent an increased risk of developing depression, especially if the seizures do not generalize. The two-pore domain potassium channel-TWIK-related K+ channel (TREK-1) plays important roles in both epilepsy and depression. However, the changes in its expression in patients with epilepsy with comorbid depression remain unclear. In the present study, we analyzed depressive symptoms using neuropsychiatric ...
Source: Epilepsy and Behaviour - June 11, 2021 Category: Neurology Authors: Xiao-Li Li Chong-Yang Tang Shu Wang Meng Zhao Xiong-Fei Wang Tian-Fu Li Xue-Ling Qi Guo-Ming Luan Yu-Guang Guan Source Type: research

Attitudes of individuals in Eastern Turkey toward epilepsy and the factors associated with these attitudes
This study was performed to analyze the attitudes of individuals in eastern Turkey toward epilepsy and the factors associated with these attitudes.METHODS: Designed as a cross-sectional descriptive study, this study was performed from January 28 to February 8, 2021. A snowball sampling technique was used to select the study sample, and a survey was sent online to individuals aged 18 or above. A total of 617 individuals who filled in this online survey form were included in this research. Data were collected via a personal information form and the Public Attitudes Toward Epilepsy (PATE) scale.RESULTS: The results showed tha...
Source: Epilepsy and Behaviour - June 10, 2021 Category: Neurology Authors: G ülcan Bahcecioglu Turan Meyreme Aksoy Z ülfünaz Özer Source Type: research

Two-minute exercise testing is sufficient to estimate maximal cardiorespiratory fitness in people with epilepsy
Epilepsy Behav. 2021 Jun 7;121(Pt A):108086. doi: 10.1016/j.yebeh.2021.108086. Online ahead of print.ABSTRACTWe aimed to examine the agreement between submaximal cardiopulmonary exercise testing (CPET) measures and peak oxygen consumption (VO2peak) in adults with epilepsy. Data from a randomized controlled trial with adults with epilepsy (N = 21) were analyzed. VO2peak was assessed using indirect calorimetry during a treadmill graded maximal CPET. Oxygen uptake efficiency slope (OUES) was calculated from the relationship between oxygen uptake and minute ventilation during the entire test (OUESpeak) and the first 2 (OUES2mi...
Source: Epilepsy and Behaviour - June 10, 2021 Category: Neurology Authors: Natan Feter C ésar A Häfele J úlia Cassuriaga Emily C Smith V ítor Häfele Lucas Rosseto Jeff S Coombes Airton J Rombaldi Marcelo C da Silva Source Type: research

SUDEP education among U.S. and international neurology trainees
Epilepsy Behav. 2021 Jun 7;121(Pt A):108098. doi: 10.1016/j.yebeh.2021.108098. Online ahead of print.ABSTRACTWe evaluated baseline sudden unexpected death in epilepsy (SUDEP) knowledge and counseling practices among national and international adult neurology trainees with a 12-question online survey. The survey was emailed to all 169 U.S. neurology residency program directors and select international neurology/epilepsy program leaders. Program leaders were asked to distribute the survey link to adult neurology trainees. There were 161 respondents in the U.S. and 171 respondents outside the U.S. The latter were from 25 Lati...
Source: Epilepsy and Behaviour - June 10, 2021 Category: Neurology Authors: F ábio A Nascimento Juliana Laze Daniel Friedman Alice Lam Orrin Devinsky Source Type: research

Individual prediction of motor vehicle accidents for patients with epilepsy
The objective of the study was to design a clinically useful tool to predict the risk of seizure-related motor vehicle accidents (MVAs) for people with epilepsy (PWE). Participants were patients who visited our epilepsy center in West China Hospital from October 2012 to October 2019 and were divided into a primary cohort and a validation cohort. Ultimately, we included 525 patients in the primary cohort and 86 patients in the validation cohort. Proportional hazard regression was performed to measure the prognostic factors of car accidents. The outcome was used to create a nomogram model. The final model had 7 factors, with...
Source: Epilepsy and Behaviour - June 10, 2021 Category: Neurology Authors: Mintao Lin Jiani Chen Sisi Li Yingjie Qin Xuruan Wang Yadong Liu Qi Zhang Ammar Taha Abdullah Abdulaziz Dong Zhou Jinmei Li Source Type: research

Epilepsy and the smell of fear
Epilepsy Behav. 2021 Jun 7;121(Pt A):108078. doi: 10.1016/j.yebeh.2021.108078. Online ahead of print.ABSTRACTOBJECTIVE: In our canine scent detection research involving a specific volatile organic compound (VOC) associated with human epileptic seizure, we began to suspect involvement of the primitive neural networks associated with production of a previously undescribed human alarm pheromone as the origin of our seizure scent. We hypothesized that if we presented fear-scented sweat to our canine seizure scent detection team, and they identified the fear scent as their seizure scent, then that would suggest that they are id...
Source: Epilepsy and Behaviour - June 10, 2021 Category: Neurology Authors: E H Maa J Arnold C K Bush Source Type: research

Attitudes of individuals in Eastern Turkey toward epilepsy and the factors associated with these attitudes
This study was performed to analyze the attitudes of individuals in eastern Turkey toward epilepsy and the factors associated with these attitudes.METHODS: Designed as a cross-sectional descriptive study, this study was performed from January 28 to February 8, 2021. A snowball sampling technique was used to select the study sample, and a survey was sent online to individuals aged 18 or above. A total of 617 individuals who filled in this online survey form were included in this research. Data were collected via a personal information form and the Public Attitudes Toward Epilepsy (PATE) scale.RESULTS: The results showed tha...
Source: Epilepsy and Behaviour - June 10, 2021 Category: Neurology Authors: G ülcan Bahcecioglu Turan Meyreme Aksoy Z ülfünaz Özer Source Type: research

Two-minute exercise testing is sufficient to estimate maximal cardiorespiratory fitness in people with epilepsy
Epilepsy Behav. 2021 Jun 7;121(Pt A):108086. doi: 10.1016/j.yebeh.2021.108086. Online ahead of print.ABSTRACTWe aimed to examine the agreement between submaximal cardiopulmonary exercise testing (CPET) measures and peak oxygen consumption (VO2peak) in adults with epilepsy. Data from a randomized controlled trial with adults with epilepsy (N = 21) were analyzed. VO2peak was assessed using indirect calorimetry during a treadmill graded maximal CPET. Oxygen uptake efficiency slope (OUES) was calculated from the relationship between oxygen uptake and minute ventilation during the entire test (OUESpeak) and the first 2 (OUES2mi...
Source: Epilepsy and Behaviour - June 10, 2021 Category: Neurology Authors: Natan Feter C ésar A Häfele J úlia Cassuriaga Emily C Smith V ítor Häfele Lucas Rosseto Jeff S Coombes Airton J Rombaldi Marcelo C da Silva Source Type: research

SUDEP education among U.S. and international neurology trainees
Epilepsy Behav. 2021 Jun 7;121(Pt A):108098. doi: 10.1016/j.yebeh.2021.108098. Online ahead of print.ABSTRACTWe evaluated baseline sudden unexpected death in epilepsy (SUDEP) knowledge and counseling practices among national and international adult neurology trainees with a 12-question online survey. The survey was emailed to all 169 U.S. neurology residency program directors and select international neurology/epilepsy program leaders. Program leaders were asked to distribute the survey link to adult neurology trainees. There were 161 respondents in the U.S. and 171 respondents outside the U.S. The latter were from 25 Lati...
Source: Epilepsy and Behaviour - June 10, 2021 Category: Neurology Authors: F ábio A Nascimento Juliana Laze Daniel Friedman Alice Lam Orrin Devinsky Source Type: research

Individual prediction of motor vehicle accidents for patients with epilepsy
The objective of the study was to design a clinically useful tool to predict the risk of seizure-related motor vehicle accidents (MVAs) for people with epilepsy (PWE). Participants were patients who visited our epilepsy center in West China Hospital from October 2012 to October 2019 and were divided into a primary cohort and a validation cohort. Ultimately, we included 525 patients in the primary cohort and 86 patients in the validation cohort. Proportional hazard regression was performed to measure the prognostic factors of car accidents. The outcome was used to create a nomogram model. The final model had 7 factors, with...
Source: Epilepsy and Behaviour - June 10, 2021 Category: Neurology Authors: Mintao Lin Jiani Chen Sisi Li Yingjie Qin Xuruan Wang Yadong Liu Qi Zhang Ammar Taha Abdullah Abdulaziz Dong Zhou Jinmei Li Source Type: research

Epilepsy and the smell of fear
Epilepsy Behav. 2021 Jun 7;121(Pt A):108078. doi: 10.1016/j.yebeh.2021.108078. Online ahead of print.ABSTRACTOBJECTIVE: In our canine scent detection research involving a specific volatile organic compound (VOC) associated with human epileptic seizure, we began to suspect involvement of the primitive neural networks associated with production of a previously undescribed human alarm pheromone as the origin of our seizure scent. We hypothesized that if we presented fear-scented sweat to our canine seizure scent detection team, and they identified the fear scent as their seizure scent, then that would suggest that they are id...
Source: Epilepsy and Behaviour - June 10, 2021 Category: Neurology Authors: E H Maa J Arnold C K Bush Source Type: research

Epilepsy on social media: An exploratory study of Arabic language content
Epilepsy Behav. 2021 Jun 6;121(Pt A):108089. doi: 10.1016/j.yebeh.2021.108089. Online ahead of print.ABSTRACTThis exploratory study provides an overview of Arabic language content for epilepsy available on three social media platforms: Facebook, Twitter, and YouTube, from the time that the platforms came into being up to the end of the year 2020. Two Arabic keywords that mean "epilepsy" and "convulsion" were used on the search engine of each platform to extract related content. Two reviews were conducted for 300 randomly selected pages, accounts, and videos from a total of 795 related published ones on ...
Source: Epilepsy and Behaviour - June 9, 2021 Category: Neurology Authors: Gheed Mufied Alsalem Source Type: research

Pediatric epilepsy and psychoeducational interventions: A review of the literature
Epilepsy Behav. 2021 Jun 6;121(Pt A):108084. doi: 10.1016/j.yebeh.2021.108084. Online ahead of print.ABSTRACTFor many individuals, living with epilepsy is truly a family affair throughout the life span. When it comes to childhood epilepsy, the unpredictability of seizure patterns, comorbid conditions, the risk of sudden unexpected death in epilepsy (SUDEP), and societal stigma can be emotionally taxing on children and their primary caregivers. To this end, this article proposes to review psychoeducational interventions provided to primary caregivers of children with an epilepsy diagnosis and the impact of such intervention...
Source: Epilepsy and Behaviour - June 9, 2021 Category: Neurology Authors: A Maya Kaye Source Type: research

The role of genetic polymorphisms in executive functioning performance in temporal lobe epilepsy
Epilepsy Behav. 2021 Jun 5;121(Pt A):108088. doi: 10.1016/j.yebeh.2021.108088. Online ahead of print.ABSTRACTOBJECTIVE: To explore the role of several genetic polymorphisms (APOE ε4, BDNF Met, and COMT Val) in executive functioning performance in patients with pharmacoresistant temporal lobe epilepsy (TLE).METHODS: Ninety-three adults (51 female, mean age = 39 years) with TLE completed executive functioning measures as part of a comprehensive preoperative neuropsychological evaluation, including Trail Making Test (Part B), Wisconsin Card Sorting Test (Conceptual Level Responses and Perseverative Errors), Color Word...
Source: Epilepsy and Behaviour - June 8, 2021 Category: Neurology Authors: Christine Doherty Tyler G Kinzy Lisa Ferguson Jessica Altemus Bruce P Hermann Charis Eng Imad Najm Robyn M Busch Source Type: research

The Epworth Sleepiness Scale in epilepsy: Internal consistency and disease-related associations
CONCLUSIONS: This study provides validity for the use of the ESS in adult populations with epilepsy.PMID:34102473 | DOI:10.1016/j.yebeh.2021.108099 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - June 8, 2021 Category: Neurology Authors: Niratchada Sap-Anan Maeve Pascoe Lu Wang Madeleine M Grigg-Damberger Noah D Andrews Nancy Foldvary-Schaefer Source Type: research

The role of genetic polymorphisms in executive functioning performance in temporal lobe epilepsy
Epilepsy Behav. 2021 Jun 5;121(Pt A):108088. doi: 10.1016/j.yebeh.2021.108088. Online ahead of print.ABSTRACTOBJECTIVE: To explore the role of several genetic polymorphisms (APOE ε4, BDNF Met, and COMT Val) in executive functioning performance in patients with pharmacoresistant temporal lobe epilepsy (TLE).METHODS: Ninety-three adults (51 female, mean age = 39 years) with TLE completed executive functioning measures as part of a comprehensive preoperative neuropsychological evaluation, including Trail Making Test (Part B), Wisconsin Card Sorting Test (Conceptual Level Responses and Perseverative Errors), Color Word...
Source: Epilepsy and Behaviour - June 8, 2021 Category: Neurology Authors: Christine Doherty Tyler G Kinzy Lisa Ferguson Jessica Altemus Bruce P Hermann Charis Eng Imad Najm Robyn M Busch Source Type: research

The Epworth Sleepiness Scale in epilepsy: Internal consistency and disease-related associations
CONCLUSIONS: This study provides validity for the use of the ESS in adult populations with epilepsy.PMID:34102473 | DOI:10.1016/j.yebeh.2021.108099 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - June 8, 2021 Category: Neurology Authors: Niratchada Sap-Anan Maeve Pascoe Lu Wang Madeleine M Grigg-Damberger Noah D Andrews Nancy Foldvary-Schaefer Source Type: research