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Facial emotion processing in patients with seizure disorders.
This study provides preliminary evidence that patients with PNES exhibit altered facial emotion processing compared with patients with TLE and HCs and increased amygdala functional connectivity compared with TLE. These findings identify potential key differences in facial emotion processing reflective of neurophysiologic markers of neural circuitry alterations that can be used to generate further hypotheses for developing studies that examine the contributions of emotion processing to the development and maintenance of PNES. PMID: 29309953 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - January 5, 2018 Category: Neurology Authors: Szaflarski JP, Allendorfer JB, Nenert R, LaFrance WC, Barkan HI, DeWolfe J, Pati S, Thomas AE, Ver Hoef L Tags: Epilepsy Behav Source Type: research

Impaired theory of mind in Chinese children and adolescents with idiopathic generalized epilepsy: Association with behavioral manifestations of executive dysfunction.
Abstract BACKGROUND: Epilepsy is a common neurological disorder with a core feature of cognitive impairments. Previous studies showed that patients with focal epilepsy have deficits in both theory of mind (ToM) and executive function (EF). However, there are few studies of ToM in patients with idiopathic generalized epilepsy (IGE), especially in populations with pediatric epilepsy. The aim of this study was to examine the characteristics of ToM and EF, including some of their subcomponents, and explore the relationship between them in Chinese children with IGE. MATERIALS AND METHODS: We recruited 54 children ...
Source: Epilepsy and Behaviour - January 5, 2018 Category: Neurology Authors: Zhang T, Chen L, Wang Y, Zhang M, Wang L, Xu X, Xiao G, Chen J, Shen Y, Zhou N Tags: Epilepsy Behav Source Type: research

Verbal learning and memory outcome in selective amygdalohippocampectomy versus temporal lobe resection in patients with hippocampal sclerosis.
CONCLUSION: In patients with drug-resistant focal MTLE, HS and no magnetic resonance imaging (MRI) signs of dual pathology, selective amygdalohippocampectomy results in sustained seizure freedom and better memory function compared with patients operated with nonselective temporal lobe resection. PMID: 29306849 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - January 4, 2018 Category: Neurology Authors: Foged MT, Vinter K, Stauning L, Kjær TW, Ozenne B, Beniczky S, Paulson OB, Madsen FF, Pinborg LH, Danish Epilepsy Surgery Group Tags: Epilepsy Behav Source Type: research

Allergy in patients with anti-N-methyl-d-aspartate receptor encephalitis.
CONCLUSIONS: Patients with anti-NMDAR encephalitis show higher allergic rate than those with virus encephalitis. Patients with allergy show higher CSF antibody titers and greater illness severity. However, the final outcome of anti-NMDAR encephalitis was not influenced. PMID: 29306850 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - January 4, 2018 Category: Neurology Authors: Jiang XY, Zhang L, Jiang X, Abdulaziz ATA, Wang YH, Li JM, Zhou D Tags: Epilepsy Behav Source Type: research

Phenotype variability of GLUT1 deficiency syndrome: Description of a case series with novel SLC2A1 gene mutations.
PMID: 29306089 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - January 3, 2018 Category: Neurology Authors: Di Vito L, Licchetta L, Pippucci T, Baldassari S, Stipa C, Mostacci B, Alvisi L, Tinuper P, Bisulli F Tags: Epilepsy Behav Source Type: research

Pregestational stress attenuated fertility rate in dams and increased seizure susceptibility in offspring.
Abstract Many studies have found that stress during pregnancy is linked to an increased incidence of epileptic behaviors and reproductive disorders. However, few works have investigated the effect of pregestational stress on seizure susceptibility in the offspring. We investigated the effect of pregestational stress on epileptic behaviors in the offspring as well as fertility rate in dams. The male and female rats were randomly divided into four groups to form a combination of control and stressed groups for each sex. The rats were subjected to predatory stress (exposed to a cat) twice per day for 50 (male) and 15...
Source: Epilepsy and Behaviour - January 3, 2018 Category: Neurology Authors: Mahmoodkhani M, Saboory E, Roshan-Milani S, Azizi N, Karimipour M, Rasmi Y, Gholinejad Z Tags: Epilepsy Behav Source Type: research

Patients' perspectives on management and barriers of regular antiepileptic drug intake.
Abstract PURPOSE: The aim of our study was to assess the management of drug intake and potential barriers to adherence reported by two different patient groups. METHODS: The study was performed in cooperation with the Regional Chamber of Pharmacists of Rhineland-Palatinate and three neurologists in private practice specialized in epileptology. In total, 108 patients surveyed in 43 pharmacies (Group P) and 118 patients treated by the specialized neurologists (Group N) completed anonymously a questionnaire on intake of antiepileptic drugs (AEDs). The statistical evaluation was performed using nonparametric test...
Source: Epilepsy and Behaviour - December 29, 2017 Category: Neurology Authors: May TW, Berkenfeld R, Dennig D, Scheid B, Hausfeld H, Walther S, Specht U Tags: Epilepsy Behav Source Type: research

Symptoms of anxiety and depression and family's quality of life in children and adolescents with epilepsy.
CONCLUSIONS: Anxiety and depression in CAWE are independent from the characteristics of the disease but are correlated to the lower well-being of the family. A search of these emotional problems is recommended for better care of the patients and their families. PMID: 29289902 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - December 28, 2017 Category: Neurology Authors: Cianchetti C, Bianchi E, Guerrini R, Baglietto MG, Briguglio M, Cappelletti S, Casellato S, Crichiutti G, Lualdi R, Margari L, Romeo A, Beghi E, TASCA Study Group Tags: Epilepsy Behav Source Type: research

Intracerebroventricular administration of cigarette smoke condensate induced generalized seizures reduced by muscarinic receptor antagonist in rats.
Abstract Tobacco smoking is considered the greatest risk factor for early death caused by noncommunicable diseases. Currently, there are more than one billion tobacco smokers in the world predisposed to many diseases including heart attack, stroke, cancer, and premature birth or birth defects related to the consumption of cigarettes. However, studies on the association between tobacco smoking and seizures or epilepsy are insufficient and not well documented. In the present study, the authors examined the convulsive effects of the intracerebroventricular administration of cigarette smoke condensate (CSC, 2μl/Rat...
Source: Epilepsy and Behaviour - December 28, 2017 Category: Neurology Authors: Laadraoui J, Bezza K, El Gabbas Z, Marhoume F, Wakrim EM, Ferehan H, Aboufatima R, Sokar Z, Kissani N, Chait A Tags: Epilepsy Behav Source Type: research

Favorable adverse effect profile of brivaracetam vs levetiracetam in a preclinical model.
ant L Abstract Levetiracetam (LEV), and its newer selective analog brivaracetam (BRV), are two seizure medications that share an innovative mechanism of action targeting the Synaptic Vesicle Protein 2A (SV2A), altering neurotransmitter release and decreasing seizure frequency. Behavioral changes are the most significant adverse effects reported by patients taking LEV. We hypothesize that BRV, the more potent SV2A analog, could exert less behavioral side effects, as it requires lower doses than LEV. Using Kainic Acid (KA)-treated and control rats, we measured adverse behavioral effect profiles of LEV, BRV, or Salin...
Source: Epilepsy and Behaviour - December 26, 2017 Category: Neurology Authors: Sanon NT, Gagné J, Wolf DC, Aboulamer S, Bosoi CM, Simard A, Messiet E, Desgent S, Carmant L Tags: Epilepsy Behav Source Type: research

Impact of vagus nerve stimulation on sleep-related breathing disorders in adults with epilepsy.
CONCLUSION: Despite the relatively modest clinical impact on epilepsy, in view of the associated cardiovascular risk factor development, easy treatment, and the relatively high SAS prevalence, routine screening for SAS before and after VNS implantation may represent a reasonable practice. PMID: 29287215 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - December 26, 2017 Category: Neurology Authors: Salvadé A, Ryvlin P, Rossetti AO Tags: Epilepsy Behav Source Type: research

The effectiveness and safety of lacosamide in children with epilepsy in a clinical practice setting.
az-Gómez A Abstract BACKGROUND: Seizures in up to 30% of children with epilepsy become refractory to treatment, decreasing their quality of life. Studies suggest that lacosamide may be effective in pediatric patients with refractory epilepsy. AIMS: To assess the effectiveness and safety of lacosamide in a population of children with mostly focal refractory epilepsy. METHODS: Retrospective analysis of children aged
Source: Epilepsy and Behaviour - December 26, 2017 Category: Neurology Authors: Sanmartí-Vilaplana F, Díaz-Gómez A Tags: Epilepsy Behav Source Type: research

Association of white matter diffusion characteristics and cognitive deficits in temporal lobe epilepsy.
pos HM, Camacho-Téllez V, Concha L Abstract OBJECTIVE: The purpose of this study was to evaluate the relation between cognitive performance and white matter (WM) integrity in patients with temporal lobe epilepsy (TLE) with mesial temporal sclerosis (MTS). METHODS: We included 26 patients with TLE (10 right, 16 left onset) as well as 24 healthy controls matched for age, gender, and years of education. In addition to quantitative hippocampal volume and transverse relaxation (T2) evaluation, whole-brain WM was analyzed using fractional anisotropy (FA) maps, derived from the diffusion tensor model. Average...
Source: Epilepsy and Behaviour - December 26, 2017 Category: Neurology Authors: Rodríguez-Cruces R, Velázquez-Pérez L, Rodríguez-Leyva I, Velasco AL, Trejo-Martínez D, Barragán-Campos HM, Camacho-Téllez V, Concha L Tags: Epilepsy Behav Source Type: research

Clinical correlates of negative health events in a research sample with epilepsy.
Abstract AIMS: In spite of advances in care, people with epilepsy experience negative health events (NHEs), such as seizures, emergency department (ED) visits, and hospitalizations. Being able to identify characteristics that are associated with NHE risk can help inform care approaches that reduce complications and burden. This analysis using baseline data from a larger randomized epilepsy self-management clinical trial assessed the relationship between demographic and clinical variables vs. seizure-related complications among people with epilepsy. METHODS: Data were derived from a baseline sample of a larger...
Source: Epilepsy and Behaviour - December 23, 2017 Category: Neurology Authors: Kumar N, Colon-Zimmermann K, Fuentes-Casiano E, Liu H, Tatsuoka C, Cassidy KA, Kahriman M, Chen P, Sajatovic M Tags: Epilepsy Behav Source Type: research

How to assess physical activity in people with epilepsy?
PMID: 29277534 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - December 22, 2017 Category: Neurology Authors: Vancini RL, Andrade MS, de Paula Oliveira HR, de Lira CAB Tags: Epilepsy Behav Source Type: research

Knowledge about epilepsy in university health students: A multicenter study.
Abstract Even with economic development and improvements in health care around the world, it is estimated that nowadays, 50 million people have epilepsy. It is one of the most prevalent neurological diseases, yet it is still surrounded by prejudice, stigma, lack of awareness, and wrong attitudes of the population towards the disease. The aim of this study was to evaluate and compare the knowledge about epilepsy in health students from different countries: Brazil, Argentina, Portugal, United States, and South Africa. Students were asked to complete a survey regarding knowledge about epilepsy (the Epilepsy Knowledge...
Source: Epilepsy and Behaviour - December 21, 2017 Category: Neurology Authors: Souza P, Portes LA, Thomas RK, Bonito JR, Rua M, Pacheco FJ, Plaatjes P, Oliveira NC Tags: Epilepsy Behav Source Type: research

Interictal cardiac repolarization abnormalities in people with epilepsy.
Abstract BACKGROUND AND OBJECTIVE: The occurrence of cardiac electrical abnormalities such as repolarization disorders in patients with epilepsy was previously documented and may, in part, clarify the mechanism of sudden unexpected death in those patients. The aim of this study was to investigate the frequency of cardiac repolarization disorders among patients with epilepsy and whether specific demographic- or disease-related features were associated with their occurrence. SUBJECTS AND METHODS: This cross-sectional study was carried out on 1000 subjects with epilepsy who were compared with age- and sex-matche...
Source: Epilepsy and Behaviour - December 20, 2017 Category: Neurology Authors: Kishk NA, Sharaf Y, Ebraheim AM, Baghdady Y, Alieldin N, Afify A, Eldamaty A Tags: Epilepsy Behav Source Type: research

A clinical social worker's epilepsy treatment perspective.
PMID: 29274814 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - December 20, 2017 Category: Neurology Authors: Vosburgh S, Owens S Tags: Epilepsy Behav Source Type: research

Antidepressants in people with epilepsy: A double-edge sword!
ini F PMID: 29274815 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - December 20, 2017 Category: Neurology Authors: Calabrò RS, Manuli A, Portaro S, Naro A, Quattrini F Tags: Epilepsy Behav Source Type: research

Evaluation of the "non-epileptic" patient in a tertiary center epilepsy clinic.
CONCLUSIONS: A significant proportion of patients seen in our tertiary care epilepsy clinic is in fact, not patients with epilepsy. Enhanced knowledge of these differential diagnosis and important anamnesis components to rule out seizures will help improve guidelines for referral to Epilepsy clinic and cost-effectively optimize the use of paraclinical investigations. PMID: 29268170 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - December 18, 2017 Category: Neurology Authors: Pana R, Labbé A, Dubeau F, Kobayashi E Tags: Epilepsy Behav Source Type: research

The clinical impact of integration of magnetoencephalography in the presurgical workup for refractory nonlesional epilepsy.
CONCLUSION: In this single center retrospective study, MEG would have changed patient management, icEEG planning, and surgical outcome in a significant percentage of patients with NLRFE and should be considered in the presurgical workup in those patients. PMID: 29253675 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - December 15, 2017 Category: Neurology Authors: Mohamed IS, Bouthillier A, Bérubé A, Cossette P, Finet P, Saint-Hilaire JM, Robert M, Nguyen DK Tags: Epilepsy Behav Source Type: research

The electroclinical spectrum, etiologies, treatment and outcome of nonconvulsive status epilepticus in the elderly.
CONCLUSION: In the elderly, NCSE has heterogeneous electroclinical phenotypes and etiologies. In spite of the treatment limitations conditioned by the comorbidities, more aggressive treatments could be justified to reduce mortality in patients with high STESS scores. PMID: 29253676 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - December 15, 2017 Category: Neurology Authors: Canas N, Delgado H, Silva V, Pinto AR, Sousa S, Simões R, Inácio N, Vale J Tags: Epilepsy Behav Source Type: research

Internalizing and externalizing symptoms in preschool and school-aged children with epilepsy: Focus on clinical and EEG features.
CONCLUSIONS: Several clinical and EEG features are associated with an increased risk for emotional and behavioral comorbidities in children with epilepsy. Their identification may foster an early diagnosis and appropriate care, limiting the worsening of psychiatric symptoms and their impact on quality of life and health status. A better understanding of the underlying clinical and molecular mechanisms is needed to further improve prevention and treatment interventions. PMID: 29253677 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - December 15, 2017 Category: Neurology Authors: Dal Canto G, Pellacani S, Valvo G, Masi G, Ferrari AR, Sicca F Tags: Epilepsy Behav Source Type: research

The influence of EEG-detected nocturnal centrotemporal discharges on the expression of core symptoms of ADHD in children with benign childhood epilepsy with centrotemporal spikes (BCECTS): A prospective study in a tertiary referral center.
aron;lejšková H Abstract Benign childhood epilepsy with centrotemporal spikes (BCECTS) is the most frequent benign focal epilepsy in childhood. Although it is described as a benign epilepsy syndrome, many studies have revealed that a significant number of patients have some degree of neuropsychological impairment. Thirty-two patients with BCECTS aged 6-11years were included in the study. All patients (without any antiepileptic or psychiatric medication) underwent all-night EEG monitoring and complex neuropsychological testing to diagnose the presence of core symptoms of attention-deficit/hyperactivit...
Source: Epilepsy and Behaviour - December 15, 2017 Category: Neurology Authors: Danhofer P, Pejčochová J, Dušek L, Rektor I, Ošlejšková H Tags: Epilepsy Behav Source Type: research

Impact of the modified Atkins diet on cardiovascular health in adults with epilepsy.
CONCLUSION: Our results provide clinical evidence demonstrating the cardiovascular safety of a high-fat, low-carbohydrate diet used in adults with epilepsy for at least 12months. It also highlights potential markers of cardiovascular risk - small dense LDL particles - that should be closely monitored in adults treated with diet therapy long-term. PMID: 29253679 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - December 15, 2017 Category: Neurology Authors: McDonald TJW, Ratchford EV, Henry-Barron BJ, Kossoff EH, Cervenka MC Tags: Epilepsy Behav Source Type: research

Effect of lacosamide on depression and anxiety symptoms in patients with focal refractory epilepsy: A prospective multicenter study.
i JÁ Abstract INTRODUCTION: Depression is the main psychiatric comorbidity in epilepsy with an estimated prevalence between 20% and 55% and one of the main determinants of quality of life. The aim of this study was to investigate the effect of lacosamide (LCM) on mood and anxiety symptoms in patients with focal onset seizures (FOS). The secondary objective was to evaluate if the potential modifications in variables were related to seizure control or to the intrinsic effect of LCM. MATERIAL AND METHODS: We performed a prospective multicenter study in 8 tertiary epilepsy centers in adults with FOS in whi...
Source: Epilepsy and Behaviour - December 15, 2017 Category: Neurology Authors: Rocamora R, Ley M, Molins A, Toledo M, Sansa G, Bertol V, Becerra JL, Carreño M, Mauri JÁ Tags: Epilepsy Behav Source Type: research

Pre- and long-term postoperative courses of hippocampus-associated memory impairment in epilepsy patients with antibody-associated limbic encephalitis and selective amygdalohippocampectomy.
CONCLUSIONS: While memory demonstrated some decline in the long run, what is most important is that a progressive decline in memory is seldom found after sAH in patients with LE. Moreover, the dynamics in performance and MRI before and after surgery reveal disease dynamics independent of surgery. Selective amygdalohippocampectomy can lead to seizure freedom, but should be considered as a last resort treatment option for drug-resistant patients with temporal lobe epilepsy due to LE. Particular caution is recommended in patients with GAD65-LE. PMID: 29253681 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - December 15, 2017 Category: Neurology Authors: Hansen N, Ernst L, Rüber T, Widman G, Becker AJ, Elger CE, Helmstaedter C Tags: Epilepsy Behav Source Type: research

A discrete-choice experiment to elicit preferences of patients with epilepsy for self-management programs.
CONCLUSION: Given the heterogeneity of the epilepsies, preferences, and dispreferences across subgroups, our study highlights that if full account is not taken of different segmentation strategies when designing a self-management program, a large proportion of the population may not be attracted to it. PMID: 29248866 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - December 14, 2017 Category: Neurology Authors: Atkinson-Clark E, Charokopou M, Van Osselaer N, Hiligsmann M Tags: Epilepsy Behav Source Type: research

People with epilepsy are diagnosed most often with unspecified epilepsy, followed by focal epilepsy, generalized convulsive epilepsy, and generalized nonconvulsive epilepsy-US MarketScan data, 2010-2015.
Abstract The distribution of epilepsy types varies by age, etiology, provider diagnostic capabilities, and assessment criteria. No recent US study has examined the distribution of epilepsy types in a large, population-based sample of people with epilepsy. We used MarketScan data from January 1, 2010 through September 30, 2015, to estimate the proportion of epilepsy types among all (N=370,570) individuals diagnosed with epilepsy. We identified cases of epilepsy as individuals with at least one International Classification of Disease, 9th version (ICD-9) diagnostic code of 345.X and the use of at least one antiseizu...
Source: Epilepsy and Behaviour - December 14, 2017 Category: Neurology Authors: Sapkota S, Kobau R, Pastula DM, Zack MM Tags: Epilepsy Behav Source Type: research

Seizure activity and individual vulnerability on first-episode interictal psychosis in epilepsy.
CONCLUSIONS: The accumulation of seizure-related damages and family history of psychosis is associated with the onset of IIP episodes, particularly in the patients with PE. Seizure activity and individual vulnerability to psychosis are likely to be interacted for as the development of IIP in patients with epilepsy. PMID: 29249448 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - December 14, 2017 Category: Neurology Authors: Adachi N, Akanuma N, Fenwick P, Ito M, Okazaki M, Ishida S, Sekimoto M, Kato M, Onuma T Tags: Epilepsy Behav Source Type: research

"By working together and caring for one another we can win this fight": A qualitative exploration of a traditional healer's perspectives of care of people with epilepsy in a South African urban township in Cape Town.
"By working together and caring for one another we can win this fight": A qualitative exploration of a traditional healer's perspectives of care of people with epilepsy in a South African urban township in Cape Town. Epilepsy Behav. 2017 Dec 14;: Authors: Keikelame MJ, Swartz L Abstract There is a gap in knowledge about the construction of care in the Global South where biomedical care remains largely inaccessible to many people, resulting in people seeking health care from the indigenous sector of health care. As part of a larger study, in this, article we present findings from a single ind...
Source: Epilepsy and Behaviour - December 14, 2017 Category: Neurology Authors: Keikelame MJ, Swartz L Tags: Epilepsy Behav Source Type: research

ECoG high-gamma modulation versus electrical stimulation for presurgical language mapping.
CONCLUSION: Electrocorticographic high-γ modulation is a specific but not sensitive method for language localization compared with gold-standard ESM. Given the pooled DOR of 6.44 and AUC of 0.77, ECoG HGM can fairly reliably ascertain electrodes overlying ESM cortical language sites. PMID: 29247963 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - December 13, 2017 Category: Neurology Authors: Arya R, Horn PS, Crone NE Tags: Epilepsy Behav Source Type: research

Intraindividual variability in attentional vigilance in children with epilepsy.
Abstract Attentional vigilance, the ability to maintain focus over time, is frequently impaired in childhood epilepsy. Typically, indices of Omissions (failure to detect a target) and Commissions (responding to a nontarget) are considered primary indices of attentional vigilance. Recently, the concept of intraindividual variability (IIV) has been identified as an important measure of attentional vigilance in several pediatric and adult clinical populations, but has not yet been systematically examined in childhood epilepsy. Here, we examined IIV on the Connors Continuous Performance Task-II (CCPT-II) for 144 newly...
Source: Epilepsy and Behaviour - December 13, 2017 Category: Neurology Authors: Srnka K, Seidenberg M, Hermann B, Jones J Tags: Epilepsy Behav Source Type: research

Predictive value of preoperative statistical parametric mapping of regional glucose metabolism in mesial temporal lobe epilepsy with hippocampal sclerosis.
CONCLUSION: Our study showed that there are widespread changes in metabolism in patients with MTLE in comparison to controls, either inside or outside the temporal lobe. There are significant differences among these patients in terms of postoperative outcomes, degree of hippocampal sclerosis, and insults in their history. PMID: 29247965 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - December 13, 2017 Category: Neurology Authors: Kojan M, Doležalová I, Koriťáková E, Mareček R, Řehák Z, Hermanová M, Brázdil M, Rektor I Tags: Epilepsy Behav Source Type: research

Predictors of outcomes and refractoriness in status epilepticus: A prospective study; Methodological issues.
PMID: 29248463 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - December 13, 2017 Category: Neurology Authors: Qorbani M, Safiri S Tags: Epilepsy Behav Source Type: research

Concordance between the Wada test and neuroimaging lateralization: Influence of imaging modality (fMRI and MEG) and patient experience.
We present these discordant findings in support of the position that functional imaging and the Wada test are distinctive procedures, with little in the way of overlapping mechanisms, and that patient's experience should be taken into account when procedures are selected and offered to them. PMID: 29245083 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - December 12, 2017 Category: Neurology Authors: Kemp S, Prendergast G, Karapanagiotidis T, Baker G, Kelly TP, Patankar T, Keller SS Tags: Epilepsy Behav Source Type: research

Community-based rehabilitation offers cost-effective epilepsy treatment in rural Guinea-Bissau.
Abstract Treatment of epilepsy in low-income countries is a challenge considering the lack of resources, availability of antiepileptic drugs, and cultural beliefs. We used a community-based rehabilitation (CBR) service for the detection, monitoring, and treatment of epilepsy. A local network of trained community volunteers provided education, good quality antiepileptic drugs, and clinical follow-up for people with epilepsy (PWE). In a period of 2years, approximately 22,500 people were screened in central Guinea-Bissau, and 112 PWE were identified and registered. Monthly check-ups were offered to monitor treatment ...
Source: Epilepsy and Behaviour - December 12, 2017 Category: Neurology Authors: van Diessen E, van der Maas F, Cabral V, Otte WM Tags: Epilepsy Behav Source Type: research

Prevalence of anxiety disorders in epilepsy.
CONCLUSIONS: Panic disorder and other forms of AD are common among PWE. Age and age of seizure onset are important factors associated with AD among PWE. PMID: 29223931 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - December 7, 2017 Category: Neurology Authors: Wiglusz MS, Landowski J, Cubała WJ Tags: Epilepsy Behav Source Type: research

Pregnancy-related knowledge of women with epilepsy - An internet-based survey in German-speaking countries.
e J Abstract There are several issues, which have to be acknowledged, when treating women with epilepsy (WWE). The need for counseling WWE in Germany with epilepsy on pregnancy-related matters was stressed in several papers and medical guidelines. Physicians treating WWE in Germany therefore should be aware of the information needs of their patients. We aimed to determine the level of pregnancy-related knowledge of WWE and their informational needs concerning pregnancy and childbirth issues in German-speaking countries by an internet-based survey. The questionnaire consisted of 18 questions addressing the characte...
Source: Epilepsy and Behaviour - December 7, 2017 Category: Neurology Authors: Dierking C, Porschen T, Walter U, Rösche J Tags: Epilepsy Behav Source Type: research

Juvenile myoclonic epilepsy - An insider's guide.
PMID: 29223414 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - December 6, 2017 Category: Neurology Authors: Counihan TJ Tags: Epilepsy Behav Source Type: research

The Temple Star Transitional Model of Care for epilepsy; the outcome of a quality improvement project.
CONCLUSION: This quality improvement initiative identified the need for transitional care to begin at an early age. This study engaged parents in a process to improve adolescent and transitional care for adolescents with epilepsy. This study also highlights the importance of introducing a detailed preparatory phase for a transitional and adolescent care in epilepsy. PMID: 29223006 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - December 6, 2017 Category: Neurology Authors: Crowley SL, Byrne S, McNulty S, Keating K, Nestor T, Owen Y, O'Rourke D, Lynch B, Shahwan A, King MD Tags: Epilepsy Behav Source Type: research

Examining health service utilization, hospital treatment cost, and mortality of individuals with epilepsy and status epilepticus in New South Wales, Australia 2012-2016.
This study examined the health service utilization and hospital treatment cost of individuals with epilepsy by age group, mortality within 30days, and surgical outcomes for individuals with refractory epilepsy in New South Wales (NSW), Australia. A retrospective examination of linked hospitalization and mortality data for individuals hospitalized with a diagnosis of epilepsy during 2012-2016. Hospitalized incidence rates per 1000 population were calculated, and negative binomial regression was used to examine temporal trends. Mortality within 30days of hospitalization was identified, along with cause of death. There were 4...
Source: Epilepsy and Behaviour - December 6, 2017 Category: Neurology Authors: Mitchell RJ, Herkes G, Nikpour A, Bleasel A, Shih P, Vagholkar S, Rapport F Tags: Epilepsy Behav Source Type: research

Cognitive impairment and quality of life of people with epilepsy and neurocysticercosis in Zambia.
r J Abstract Cognitive impairment and quality of life (Qol) are important to assess the burden of epilepsy and neurocysticercosis (NCC), which are common but neglected in Sub-Saharan Africa (SSA). The aims of this study were to assess cognitive performance and Qol of people with epilepsy (PWE) in Zambia and to explore differences in PWE with and without NCC. In this community based, cross-sectional case-control-study, 47 PWE and 50 healthy controls completed five neuropsychological tests (Mini Mental State Examination (MMSE), Digit Span, Selective Reminding Test (SRT), Spatial Recall Test (SPART), Test Battery of ...
Source: Epilepsy and Behaviour - December 5, 2017 Category: Neurology Authors: Nau AL, Mwape KE, Wiefek J, Schmidt K, Abatih E, Dorny P, Praet N, Chiluba C, Schmidt H, Phiri IK, Winkler AS, Gabriël S, Blocher J Tags: Epilepsy Behav Source Type: research

The effect of a modular education program for children with epilepsy and their parents on disease management.
The objective of this study was to evaluate the efficacy of Modular Education Program for Children with Epilepsy and Their Parents on disease management. The program was prepared by researchers in an interdisciplinary team. METHOD: Children with epilepsy and their parents were included in a randomized controlled study using a pre-posttest design. All participants of the modular education program (n=184 (92 children and their 92 parents')) answered a lot of scales immediately before the program. The researcher presented the modular education program, which included eight modules (four for the children and four for the ...
Source: Epilepsy and Behaviour - December 1, 2017 Category: Neurology Authors: Turan Gürhopur FD, Işler Dalgiç A Tags: Epilepsy Behav Source Type: research

Optimizing clobazam treatment in patients with Lennox-Gastaut syndrome.
Abstract Given the complexities managing Lennox-Gastaut syndrome (LGS)-comorbid conditions, multiple associated seizure types that tend to be refractory to treatment-dosage optimization of antiepileptic drug (AED) treatment is a challenge. In the absence of clinical trial data on optimization of AED dosage in patients with LGS, dose titration is guided by personal experience, anecdotal evidence, and specific patient factors (age, comorbid conditions and medications, seizure types, etc.). The goal of this study was to determine whether a 20% increase in adjunctive clobazam was a reasonable benchmark for improved se...
Source: Epilepsy and Behaviour - December 1, 2017 Category: Neurology Authors: Isojarvi J, Gidal BE, Chung S, Wechsler RT Tags: Epilepsy Behav Source Type: research

Modulation of the anticonvulsant effect of swim stress by agmatine.
In this study, we investigated the interaction of agmatine with the anticonvulsant effect of swim stress in mice on pentylenetetrazole (PTZ)-induced seizure threshold. Then we studied the involvement of nitric oxide (NO) pathway and endogenous opioid system in that interaction. Swim stress induced an anticonvulsant effect on PTZ seizures which was opioid-independent in shorter than 1-min swim durations and opioid-dependent with longer swims, as it was completely reversed by pretreatment with naltrexone (NTX) (10mg/kg), an opioid receptor antagonist. Agmatine significantly enhanced the anticonvulsant effect of opioid-indepe...
Source: Epilepsy and Behaviour - November 28, 2017 Category: Neurology Authors: Bahremand T, Payandemehr P, Riazi K, Noorian AR, Payandemehr B, Sharifzadeh M, Dehpour AR Tags: Epilepsy Behav Source Type: research

Efficacy and safety of vigabatrin in Japanese patients with infantile spasms: Primary short-term study and extension study.
This study evaluated the efficacy and safety of vigabatrin for Japanese patients with infantile spasms. Of 15 patients (aged ≥4weeks and
Source: Epilepsy and Behaviour - November 27, 2017 Category: Neurology Authors: Ohtsuka Y Tags: Epilepsy Behav Source Type: research

Effect of atorvastatin on behavioral alterations and neuroinflammation during epileptogenesis.
Abstract Temporal lobe epilepsy (TLE) is the most frequent and medically refractory type of epilepsy in humans. In addition to seizures, patients with TLE suffer from behavioral alterations and cognitive deficits. Poststatus epilepticus model of TLE induced by pilocarpine in rodents has enhanced the understanding of the processes leading to epilepsy and thus, of potential targets for antiepileptogenic therapies. Clinical and experimental evidence suggests that inflammatory processes in the brain may critically contribute to epileptogenesis. Statins are inhibitors of cholesterol synthesis, and present pleiotropic e...
Source: Epilepsy and Behaviour - November 26, 2017 Category: Neurology Authors: Oliveira CV, Grigoletto J, Canzian JM, Duarte MMMF, Duarte T, Furian AF, Oliveira MS Tags: Epilepsy Behav Source Type: research

Seizure-induced activation of the HPA axis increases seizure frequency and comorbid depression-like behaviors.
Abstract Our laboratory recently demonstrated that seizures activate the hypothalamic-pituitary-adrenal (HPA) axis, increasing circulating levels of corticosterone (O'Toole et al., 2013). Given the well-established proconvulsant actions of corticosterone, we hypothesized that seizure-induced activation of the HPA axis may contribute to future seizure susceptibility. Further, since hypercortisolism is associated with depression, we propose that seizure-induced activation of the HPA axis may contribute to comorbid depression and epilepsy. To test this hypothesis, we generated mice lacking the GABAA receptor (GABAAR)...
Source: Epilepsy and Behaviour - November 26, 2017 Category: Neurology Authors: Hooper A, Paracha R, Maguire J Tags: Epilepsy Behav Source Type: research

Are there gender differences in those diagnosed with psychogenic nonepileptic seizures?
CONCLUSIONS: Gender differences were identified with males reporting a significantly higher use of avoidance (cognitive and behavioral avoidance of stress) and depressive symptoms. Women exhibited significantly higher rates of sexual trauma compared with male counterparts. Consequently, women also had significantly higher rates of trauma symptomatology (dissociation and sexual disturbances) which are often observed in those who have been traumatized sexually. These gender distinctions may support different first-line treatment approaches (e.g., trauma-focused; more traditional cognitive behavioral therapy) depending on the...
Source: Epilepsy and Behaviour - November 25, 2017 Category: Neurology Authors: Myers L, Trobliger R, Bortnik K, Lancman M Tags: Epilepsy Behav Source Type: research