Beyond implantation effect? Long-term seizure reduction and freedom following intracranial monitoring without additional surgical interventions.
Abstract The term 'implantation effect' is used to describe an immediate and transient improvement in seizure frequency following an intracranial study for seizure onset localization. We conducted a retrospective analysis of 190 consecutive patients undergoing intracranial electroencephalogram (EEG) monitoring, of whom 41 had no subsequent resection/ablation/stimulation; 33 had adequate data and follow-up time available for analysis. Analysis of seizure frequency following an intracranial study showed 36% (12/33) responder rate (>50% seizure reduction) at one year, decreasing and stabilizing at 20% from year 4 ...
Source: Epilepsy and Behaviour - June 29, 2020 Category: Neurology Authors: Percy J, Zaveri H, Duckrow RB, Gerrard J, Farooque P, Hirsch LJ, Spencer DD, Sivaraju A Tags: Epilepsy Behav Source Type: research

Vagus nerve stimulation in patients with therapy-resistant generalized epilepsy.
Abstract BACKGROUND: For patients with generalized epilepsy who do not respond to antiseizure medications, the therapeutic options are limited. Vagus nerve stimulation (VNS) is a treatment mainly approved for therapy-resistant focal epilepsy. There is limited information on the use of VNS on generalized epilepsies, including Lennox-Gastaut Syndrome (LGS) and genetic generalized epilepsy (GGE). METHODS: We identified patients with a diagnosis of generalized epilepsy (including LGS and GGE), who underwent VNS implantation at the London Health Sciences Centre and Western University, London, Ontario, since this t...
Source: Epilepsy and Behaviour - June 29, 2020 Category: Neurology Authors: Suller Marti A, Mirsattari SM, MacDougall K, Steven DA, Parrent A, de Ribaupierre S, Andrade A, Diosy D, McLachlan RS, Burneo JG Tags: Epilepsy Behav Source Type: research

Diagnostic gap in genetic epilepsies: A matter of age.
CONCLUSIONS: Despite the multiple implications of modern diagnostic techniques, especially genetic testing, there is a large proportion of patients with epilepsy and intellectual disability who do not have access to them. Older age and seizure freedom seem to be associated with the highest diagnostic gap. PMID: 32610249 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - June 28, 2020 Category: Neurology Authors: Aledo-Serrano A, García-Morales I, Toledano R, Jiménez-Huete A, Parejo B, Anciones C, Mingorance A, Ramos P, Gil-Nagel A Tags: Epilepsy Behav Source Type: research

Measuring the impact of epilepsy on families.
CONCLUSIONS: Findings from the current study suggest that the impact of epilepsy is highest for families that have children with active seizures at the time of their clinical visit and for those with children having treatment-resistant epilepsy. Although intuitive, this is the first study, to our knowledge, that has empirically verified these findings. PMID: 32610250 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - June 28, 2020 Category: Neurology Authors: Dawes A, Attipoe S, Mittlesteadt J, Glynn P, Rust S, Debs A, Patel AD Tags: Epilepsy Behav Source Type: research

Use of a simulation-based mastery learning curriculum for neurology residents to improve the identification and management of status epilepticus.
The objective of the study was to develop and evaluate the impact of a simulation-based mastery learning (SBML) curriculum to train neurology residents on the identification and management of SE. METHODS: We used pretest-posttest design with a retention test on SE skills for this study. Neurology residents in the second postgraduate year (PGY-2) were eligible to participate in the SE SBML curriculum. Learners completed a baseline-simulated SE skills assessment (pretest) using a 26-item dichotomous skills checklist. Next, they participated in a didactic session about the identification and management of SE, followed by...
Source: Epilepsy and Behaviour - June 27, 2020 Category: Neurology Authors: Mikhaeil-Demoa Y, Barsuk JH, Cullerd GW, Begad D, Salzman DH, Cohen ER, Templer JW, Gerard EE Tags: Epilepsy Behav Source Type: research

Evaluation of nursing students' epilepsy-related knowledge and attitudes.
This study evaluated the knowledge and attitudes of nursing students toward epilepsy. METHOD: The descriptive and cross-sectional study was conducted with the voluntary participation of 161 nursing students in their 2nd, 3rd, and 4th years of study who were registered at the summer school of Trakya University, Faculty of Health Sciences in the 2017-2018 academic year. The data were collected through a research questionnaire form and the Epilepsy Knowledge and Attitude Scales. The normal distribution of the data was tested using the one-sample Kolmogorov-Smirnov test. Nonparametric tests were used since the data were n...
Source: Epilepsy and Behaviour - June 27, 2020 Category: Neurology Authors: Unsar S, Özdemir Ö, Erol Ö, Bıkmaz Z, Yenici Bulut E Tags: Epilepsy Behav Source Type: research

Clinical and electroencephalographic features of benign childhood epilepsy with centrotemporal spikes comorbidity with attention-deficit hyperactivity disorder in Southwest China.
This study was conducted to analyze the clinical and electroencephalographic (EEG) features of attention-deficit hyperactivity disorder (ADHD) in children with benign partial epilepsy with centrotemporal spikes (BECTS) in Southwest China, to address the question of what the risk factors are for patients with BECTS who suffer from ADHD. METHODS: Overall 118 right-handed children with BECTS were included from two medical centers. Of them, 29 patients were with diagnosed ADHD according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-V) at baseline, and the remaining were considered as typ...
Source: Epilepsy and Behaviour - June 27, 2020 Category: Neurology Authors: Huang C, Hu W, Tan G, Xu Y, Liu L Tags: Epilepsy Behav Source Type: research

Neonatal SCN2A encephalopathy: A peculiar recognizable electroclinical sequence.
CONCLUSION: Neonatal SCN2A encephalopathy has a recognizable phenotype starting soon after birth with alternating partial motor seizures evolving to infantile spasms and a discontinuous EEG pattern. Seizures improve spontaneously in the first year of life. This electroclinical sequence should indicate the search of SCN2A mutation and suggest the administration of sodium channel blockers. PMID: 32603808 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - June 27, 2020 Category: Neurology Authors: Melikishvili G, Dulac O, Gataullina S Tags: Epilepsy Behav Source Type: research

The semantics of epileptic and psychogenic nonepileptic seizures and their differential diagnosis.
ia CM PMID: 32603809 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - June 27, 2020 Category: Neurology Authors: Beghi M, Cornaggia I, Diotti S, Erba G, Harder G, Magaudda A, Laganà A, Vitale C, Cornaggia CM Tags: Epilepsy Behav Source Type: research

Long-term effects of vagus nerve stimulation in refractory pediatric epilepsy: A single-center experience.
CONCLUSION: Our series had a diverse etiological profile and patients with transition to adult care. Long-term follow-up showed that VNS is an effective and well-tolerated treatment modality for refractory childhood onset epilepsy. Age at implantation, duration of epilepsy and underlying etiology are not found to be predictors of responsiveness to VNS. Higher response rates were observed for a subset of patients with focal epileptiform discharges. PMID: 32604021 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - June 27, 2020 Category: Neurology Authors: Yalnizoglu D, Ardicli D, Bilginer B, Konuskan B, Karli Oguz K, Akalan N, Turanli G, Saygi S, Topcu M Tags: Epilepsy Behav Source Type: research

Managing epilepsy in Ramadan: Guidance for healthcare providers and patients.
This article provides specific advice to help Muslim patients prepare for Ramadan and reduce chances of exacerbation in epilepsy. In addition to advice around sleep hygiene, it explores the use of drugs or preparations of drugs that will demonstrate reduced variation during periods of fasting. PMID: 32599428 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - June 26, 2020 Category: Neurology Authors: Mahmood A, Abbasi HN, Ghouri N, Mohammed R, Leach JP Tags: Epilepsy Behav Source Type: research

Role of obstetricians in promoting pregnancy-related knowledge among women with epilepsy in Japan.
In this study, we aimed to assess the needs and understand knowledge levels regarding pregnancy-related issues among Japanese WWE. We contacted 400 board-certified epileptologists and asked them to administer our questionnaire to their patients; 51 responses were analyzed. Among all participating WWE, 100% were taking medication at the time of the study, 34% had given birth, and 63% expressed a desire to have children in the near future. Additionally, the median questionnaire score on pregnancy-related matters was as low as 9.5 out of 13 points. Only 31% of WWE knew that the mode of delivery is not always cesarean delivery...
Source: Epilepsy and Behaviour - June 26, 2020 Category: Neurology Authors: Egawa M, Hara K, Ikeda M, Kono E, Miyashita S, Miyasaka N, Inaji M, Maehara T, Yoshida M Tags: Epilepsy Behav Source Type: research

Cerebrocerebellar structural covariance in temporal lobe epilepsy with hippocampal sclerosis.
CONCLUSION: There is significant asymmetry in the GMV of cerebral and cerebellar structures in patients with TLE-HS. Morphological changes are distinctly more pronounced in patients with left TLE-HS. The observed structural covariance between the cerebellum and supratentorial structures in TLE-HS suggests associations beyond the mesial temporal lobe structures and thalamus. PMID: 32599430 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - June 26, 2020 Category: Neurology Authors: Marcián V, Mareček R, Pail M, Brázdil M Tags: Epilepsy Behav Source Type: research

Enhancing epilepsy self-management and quality of life for adults with epilepsy with varying social and educational backgrounds using PAUSE to Learn Your Epilepsy.
CONCLUSION: This study demonstrated that a mobile technology-based personalized SM intervention is feasible to implement. The results provide evidence that epilepsy SM behavior and practices, QOL, outcome expectation for epilepsy treatment and management, self-efficacy, and outcome expectation and impact of epilepsy significantly improve following a personalized SM education intervention. This underscores a greater need for a pragmatic trial to test the effectiveness of personalized SM education, such as PAUSE to Learn Your Epilepsy, in broader settings specifically for the unique needs of the hard-to-reach and hard-to-tre...
Source: Epilepsy and Behaviour - June 26, 2020 Category: Neurology Authors: Pandey DK, Dasgupta R, Levy J, Wang H, Serafini A, Habibi M, Song W, Shafer PO, Loeb JA Tags: Epilepsy Behav Source Type: research

Differentiating PNES from epileptic seizures using conversational analysis on French patients: A prospective blinded study.
The objective of our study was to evaluate the contribution of linguistic analysis in the differential diagnosis between ES and PNES in a French patient population. During an extended video-electroencephalogram (video-EEG) monitoring, 13 patients presented PNES and 19 patients with ES. Two neurologists blindly and independently analyzed the interview of each patient. Rater 1 predicted the correct diagnosis in 27 of 32 patients (84%) and Rater 2 in 28 of 32 patients (88%). Interrater reliability of qualitative analysis was satisfactory (k = 0.68, interrater agreement = 84.4%). Using a simplified DSA, Rater 1 and Rat...
Source: Epilepsy and Behaviour - June 26, 2020 Category: Neurology Authors: Biberon J, de Liège A, de Toffol B, Limousin N, El-Hage W, Florence AM, Duwicquet C Tags: Epilepsy Behav Source Type: research

Intracerebroventricular administration of N-type calcium channel blocker ziconotide displays anticonvulsant, anxiolytic, and sedative effects in rats: A preclinical and pilot study.
CONCLUSION: Ziconotide displays beneficial neurobehavioral effects in a model of epilepsy with anxiety as its comorbid event. It seems that at least one of the mechanisms involved in these effects is associated with a decrease in brain corticosterone levels. The main advantage of ziconotide over benzodiazepines (routine anxiolytic and sedative drugs) is that it does not cause tolerance, dependency, and addiction. Therefore, more than ever, it is necessary to improve the convenience of drug delivery protocols and attenuate the adverse effects associated with ziconotide-based therapies. PMID: 32593873 [PubMed - as suppl...
Source: Epilepsy and Behaviour - June 25, 2020 Category: Neurology Authors: Zamani M, Budde T, Bozorgi H Tags: Epilepsy Behav Source Type: research

Epilepsy self-management during a pandemic: Experiences of people with epilepsy.
Abstract The purpose of this descriptive study was to, from the perspective of adult people with epilepsy (PWE) and caregivers of PWE, explore the effects of the current pandemic and resulting societal changes on epilepsy self-management. Ninety-four respondents completed a mixed-methods quantitative and qualitative survey focused on their epilepsy self-management experiences during the coronavirus disease-19 (COVID-19) pandemic. Respondents noted significant disruption in epilepsy self-management. Lack of ability to obtain medications or see epilepsy providers, as well as increased stress, social isolation, and c...
Source: Epilepsy and Behaviour - June 25, 2020 Category: Neurology Authors: Miller WR, Von Gaudecker J, Tanner A, Buelow JM Tags: Epilepsy Behav Source Type: research

Psychometric properties of the Persian version of the Patient-Weighted Quality of Life in Epilepsy Inventory-10-P.
Abstract BACKGROUND: The purpose of the study was to evaluate psychometric properties of the Persian version of the Patient-Weighted Quality of Life in Epilepsy Inventory-10-P (PV QOLIE-10-P). METHODS: The Persian version was obtained from the original version by standard forward/backward translation. We assessed content validity, construct validity by factor analysis, internal consistency, test-retest reliabilities, criterion validity by calculating Pearson/Spearman correlation to the Persian version of the SF-36 inventory the Persian version of the 36-Item Short Form Health Survey (PV SF-36), and discrimina...
Source: Epilepsy and Behaviour - June 24, 2020 Category: Neurology Authors: Barakchianc SN, Shati M, Mortazavi SS, Nikanfar M, Charsouei S Tags: Epilepsy Behav Source Type: research

Unexpected brain imaging findings in patients with seizures.
Abstract New imaging technologies have advanced our ability to localize the epileptogenic zone in patients with epilepsy. As a result of the constant improvement of the image quality, magnetic resonance imaging (MRI) has become the most important ancillary tool in the management of patients with epilepsy. Magnetic resonance imaging for the evaluation of patients with epilepsy should be done using a special temporal lobe protocol and read by physicians experienced with the findings in patients with epilepsy. On the other hand, in the healthy populations, incidental structural brain abnormalities have been reported ...
Source: Epilepsy and Behaviour - June 23, 2020 Category: Neurology Authors: Mesraoua B, Koepp M, Schuknecht B, Deleu D, Al Hail HJ, Melikyan G, Elsheikh L, Asadi-Pooya AA Tags: Epilepsy Behav Source Type: research

Cannabis constituents reduce seizure behavior in chemically-induced and scn1a-mutant zebrafish.
Abstract Current antiepileptic drugs (AEDs) are undesirable for many reasons including the inability to reduce seizures in certain types of epilepsy, such as Dravet syndrome (DS) where in one-third of patients does not respond to current AEDs, and severe adverse effects that are frequently experienced by patients. Epidiolex, a cannabidiol (CBD)-based drug, was recently approved for treatment of DS. While Epidiolex shows great promise in reducing seizures in patients with DS, it is used in conjunction with other AEDs and can cause liver toxicity. To investigate whether other cannabis-derived compounds could also re...
Source: Epilepsy and Behaviour - June 22, 2020 Category: Neurology Authors: Thornton C, Dickson KE, Carty DR, Ashpole NM, Willett KL Tags: Epilepsy Behav Source Type: research

Examining relations between neuropsychological and clinical epilepsy-specific factors with psychopathology and adaptive skills outcomes in youth with intractable epilepsy.
Abstract Pediatric epilepsy is a prevalent childhood neurological disorder. Youth with a diagnosis of medically uncontrollable or intractable epilepsy are at increased risk for poor neurocognitive and psychosocial functioning. To date, there is a paucity of clinical research examining and/or characterizing the relations of neuropsychological, clinical, and epilepsy-specific medical factors in clinical outcomes among youth with diagnosed intractable epilepsy. One hundred and twenty-six patients (6-20 years) with diagnosed intractable epilepsy and who were evaluated as part of a presurgical work-up and medical sta...
Source: Epilepsy and Behaviour - June 22, 2020 Category: Neurology Authors: Kertesz-Briest HA, H Hamilton A, Hartline K, Klein MJ, Gold JI Tags: Epilepsy Behav Source Type: research

Behavioral implications of temporal lobe epilepsy on social contingency.
Abstract OBJECTIVE: Temporal lobe epilepsy (TLE) is a chronic condition classically characterized by recurrent unprovoked episodes of involuntary violent motion and behavior whose degree and nature often overshadow the more subtle interictal neuropsychiatric symptoms. The purpose of this research was to investigate further the nature of cognitive impairment seen in social interaction within the population with TLE. METHODS: We recorded the dynamics of real-time sensorimotor interaction in 10 pairs of control participants and ten pairs of participants with drug-resistantTLE using a minimalistic human-computer ...
Source: Epilepsy and Behaviour - June 22, 2020 Category: Neurology Authors: Rini JF, Ochoa J Tags: Epilepsy Behav Source Type: research

Hysteria or epilepsy?
autecoeur P Abstract Hysteria and epilepsy have long been compounded by the term "hysteria-epilepsy" among neurologists and phsychiatrists, including Jean Martin Charcot. In a 114 page unpublished manuscript written circa 1815, Jean-Baptiste Louyer Villermay, French physician and student of Philippe Pinel, considered the signs that would differentiate hysteria from epilepsy. This differential diagnosis approach was proposed long before Charcot's lecture in 1868 at Salpêtrière hospital. PMID: 32585599 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - June 22, 2020 Category: Neurology Authors: Drouin E, Péréon Y, Hautecoeur P Tags: Epilepsy Behav Source Type: research

Dlg4 and Vamp2 are involved in comorbid epilepsy and attention-deficit hyperactivity disorder: A microarray data study.
CONCLUSION: Dlg4 and Vamp2 could play essential roles in comorbidity between epilepsy and ADHD. PMID: 32580088 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - June 21, 2020 Category: Neurology Authors: Xi XJ, Tang JH, Zhang BB, Xiao X, Hu XY, Wan Y, Zhou C, Lin H Tags: Epilepsy Behav Source Type: research

Use of cannabis and its products among patients in a tertiary epilepsy center: A cross-sectional survey.
nė R Abstract PURPOSE: The purpose of this study was to evaluate whether the topic of using cannabis as a treatment option for epilepsy is relevant among adult patients with the disorder and assess the possible determinant attitudes for having a history of cannabis consumption or being inclined to try it for medical purposes. MATERIAL AND METHODS: Willing adult (≥18 years) patients with diagnosed epilepsy participated in a cross-sectional survey study at a tertiary epilepsy center. The questions were related to cannabis use and opinions towards the safety and efficacy profile of cannabis for treating ep...
Source: Epilepsy and Behaviour - June 21, 2020 Category: Neurology Authors: Puteikis K, Mameniškienė R Tags: Epilepsy Behav Source Type: research

Some legal aspects of epilepsy.
CONCLUSIONS: This overview has examined three legal aspects of epilepsy, namely, driving, employment, and negligence. The concepts and interpretations should have relative applicability well beyond any narrow confines, limited to a single jurisdiction. PMID: 32575008 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - June 20, 2020 Category: Neurology Authors: Beran RG, Devereaux JA, Buchanan D Tags: Epilepsy Behav Source Type: research

Contraceptive vaginal ring reduces lamotrigine levels.
CONCLUSIONS: The findings support that the vaginal ring contraceptive method decreases lamotrigine concentrations during the active phase of treatment. This has important implications for contraceptive counseling and maintaining therapeutic levels in women of childbearing age with epilepsy. PMID: 32575009 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - June 20, 2020 Category: Neurology Authors: King A, Bachman E, Macken MP, Lee J, Gerard EE Tags: Epilepsy Behav Source Type: research

Evaluation of epilepsy and burn patterns in a tertiary hospital in southwestern Iran.
Abstract PURPOSE: Based on the high rates of burn injuries in patients with epilepsy, it is crucial to evaluate the epidemiological factors, etiology, types of burns, and outcome of these certain individuals and to enhance knowledge about the possible risks of epilepsy-related burns by preventive actions and programs. METHOD: Our retrospective study was carried out from September 2013 to February 2017 in Amir-al Momenin Hospital, a tertiary referral burns and plastic surgery healthcare center. Because of the fact that a number of patients with burns had experienced their trauma at the time of convulsion or in...
Source: Epilepsy and Behaviour - June 20, 2020 Category: Neurology Authors: Mohammadi AA, Keshavarzi A, Erfani A, Modarresi MS, Shahriarirad R, Ranjbar K Tags: Epilepsy Behav Source Type: research

Therapeutic monitoring of antiepileptic drugs: Recommendations to improve care of patients with epilepsy in the Palestinian practice.
CONCLUSION: Consensus-based recommendations that might be used in guiding TDM of AEDs in Palestine were developed. Future studies are still needed to investigate if these consensus-based recommendations can improve healthcare of PWE in Palestine. PMID: 32575011 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - June 20, 2020 Category: Neurology Authors: Shawahna R, Abdelfattah B, Shafei M, Ruzzeh S Tags: Epilepsy Behav Source Type: research

Ketamine as adjunct to midazolam treatment following soman-induced status epilepticus reduces seizure severity, epileptogenesis, and brain pathology in plasma carboxylesterase knockout mice.
Abstract Delayed treatment of cholinergic seizure results in benzodiazepine-refractory status epilepticus (SE) that is thought, at least in part, to result from maladaptive trafficking of N-methyl-d-aspartate (NMDA) and gamma-aminobutyric acid type A (GABAA) receptors, the effects of which may be ameliorated by combination therapy with the NMDA receptor antagonist ketamine. Our objective was to establish whether ketamine and midazolam dual therapy would improve outcome over midazolam monotherapy following soman (GD) exposure when evaluated in a mouse model that, similar to humans, lacks plasma carboxylesterase, gr...
Source: Epilepsy and Behaviour - June 20, 2020 Category: Neurology Authors: Marrero-Rosado BM, de Araujo Furtado M, Kundrick ER, Walker KA, Stone MF, Schultz CR, Nguyen DA, Lumley LA Tags: Epilepsy Behav Source Type: research

Deprescribing in epilepsy: "First do no net harm".
Deprescribing in epilepsy: "First do no net harm". Epilepsy Behav. 2020 Jun 20;111:107236 Authors: Romigi A, Di Gennaro G PMID: 32575013 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - June 20, 2020 Category: Neurology Authors: Romigi A, Di Gennaro G Tags: Epilepsy Behav Source Type: research

Seizures, accidental injuries at work, and reasons for resignation in people with epilepsy.
Abstract OBJECTIVE: Few studies have examined seizures, accidental injuries at work, and reasons for resignation in people with epilepsy (PWE). We performed a questionnaire survey of PWE to identify the risk of injury at work, its relationship to different seizure characteristics, and reasons for resignation. METHODS: We distributed a questionnaire survey in the outpatient clinic of a single epilepsy center. Medical information was obtained retrospectively from medical records. RESULTS: Of 200 patients who received the questionnaire, 172 responded. Two-fifths of PWE had experienced seizures at work, but ...
Source: Epilepsy and Behaviour - June 20, 2020 Category: Neurology Authors: Nishida T, Terada K, Ikeda H, Inoue Y Tags: Epilepsy Behav Source Type: research

Barriers in accessing medical cannabis for children with drug-resistant epilepsy in Canada: A qualitative study.
CONCLUSIONS: Parents pursue medical cannabis as a treatment for their children's drug-resistant epilepsy because of a perceived unmet need. However, parents encounter barriers in accessing medical cannabis in Canada, and strategies are needed to ensure that children using medical cannabis receive proper care from healthcare professionals with training in epilepsy care, antiepileptic drugs, and medical cannabis. PMID: 32570201 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - June 19, 2020 Category: Neurology Authors: Elliott J, DeJean D, Potter BK, Coyle D, Clifford T, McCoy B, Wells GA Tags: Epilepsy Behav Source Type: research

Reading-writing disorder in children with idiopathic epilepsy.
lla M Abstract Several studies have documented learning disabilities (LDs) in subjects with epilepsy, who have been shown to be at greater risk of mild neuropsychological damage, with the consequent risk of academic failure. This retrospective study aimed to investigate the peculiarities of reading and writing disorders in subjects with idiopathic epilepsy. The reading and writing performance of 35 children affected by reading and writing disorders and idiopathic epilepsy (R/WD + E group) has been compared with the performance of 37 children with only reading and writing disorders (R/WD group). A comparison gr...
Source: Epilepsy and Behaviour - June 18, 2020 Category: Neurology Authors: Germanò E, Gagliano A, Arena C, Cedro C, Vetri L, Operto FF, Pastorino GMG, Marotta R, Roccella M Tags: Epilepsy Behav Source Type: research

Suicidal behavior among people with epilepsy in Northwest Ethiopia: A comparative cross-sectional study.
CONCLUSION: The proportion of suicidal behavior is twofold higher in people with epilepsy than the general population. Routine screening for suicide risk should be an integral part of epilepsy treatment. PMID: 32563892 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - June 18, 2020 Category: Neurology Authors: Mekonen T, Getnet A, Belete A, Menberu M, Fekadu W Tags: Epilepsy Behav Source Type: research

Expert opinion: Proposed diagnostic and treatment algorithms for Lennox-Gastaut syndrome in adult patients.
Abstract Lennox-Gastaut syndrome (LGS) is a severe developmental epileptic encephalopathy diagnosed in childhood that persists through adolescence and into adulthood. While the characteristics of LGS in pediatric patients are well defined, including "drop attacks", interictal slow spike and wave electroencephalogram (EEG) activity, and intellectual disability, these features can evolve over time, and different EEG activities may be present in adult patients with LGS. This may result in missed diagnoses in these patients and subsequent challenges for the adequate treatment of their seizures. Based on disc...
Source: Epilepsy and Behaviour - June 18, 2020 Category: Neurology Authors: Montouris G, Aboumatar S, Burdette D, Kothare S, Kuzniecky R, Rosenfeld W, Chung S Tags: Epilepsy Behav Source Type: research

Proceedings of the 15th Antiepileptic Drug and Device Trials Meeting: State of the Science.
Abstract On May 22-24, 2019, the 15th Antiepileptic Drug and Device (AEDD) Trials Conference was held, which focused on current issues related to AEDD development from preclinical models to clinical prognostication. The conference featured regulatory agencies, academic laboratories, and healthcare companies involved in emerging epilepsy therapies and research. The program included discussions around funding and support for investigations in epilepsy and neurologic research, clinical trial design and integrated outcome measures for people with epilepsy, and drug development and upcoming disease-modifying therapies....
Source: Epilepsy and Behaviour - June 17, 2020 Category: Neurology Authors: Boada CM, French JA, Dumanis SB Tags: Epilepsy Behav Source Type: research

Psychological inflexibility and somatization in nonepileptic attack disorder.
CONCLUSIONS: Higher levels of CF and EA appear to be related to lower levels of mindfulness. Lower levels of mindfulness predicted greater levels of somatization, and somatization predicted NEA frequency. Interventions that tackle avoidance and increase mindfulness, such as, acceptance and commitment therapy, may be beneficial for individuals with NEAD. Future directions for research are suggested as the results indicate more research is needed. PMID: 32563053 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - June 17, 2020 Category: Neurology Authors: Cullingham T, Kirkby A, Eccles FJR, Sellwood W Tags: Epilepsy Behav Source Type: research

Long-term outcomes after epilepsy surgery, a retrospective cohort study linking patient-reported outcomes and routine healthcare data.
The objective of the study was to assess the long-term outcomes of epilepsy surgery between 1995 and 2015 in South Wales, UK, linking case note review, postal questionnaire, and routinely collected healthcare data. METHOD: We identified patients from a departmental database and collected outcome data from patient case notes, a postal questionnaire, and the QOLIE-31-P and linked with Welsh routinely collected data in the Secure Anonymised Information Linkage (SAIL) databank. RESULTS: Fifty-seven patients were included. Median age at surgery was 34 years (11-70), median: 24 years (2-56) after onset of habitual ...
Source: Epilepsy and Behaviour - June 15, 2020 Category: Neurology Authors: Kansu B, Pickrell WO, Lacey AS, Edwards F, Samolia G, Rees MI, Elwes R, Hatfield R, Gray W, Hamandi K Tags: Epilepsy Behav Source Type: research

Cardiovascular complications of epileptic seizures.
Abstract Seizure disorders are associated with multisystem complications. Cardiovascular complications account for a significant proportion of morbidity and mortality in these patients. As such, particular attention must be paid to the incidence of cardiovascular complications especially in populations at increased risk. The background for cardiac dysfunction lies in the interplay of genetic/molecular, autonomic, and iatrogenic factors that contribute to its onset. The purpose of this review was to summarize the state of literature in the last decade with regard to cardiac complications of epileptic seizures in or...
Source: Epilepsy and Behaviour - June 15, 2020 Category: Neurology Authors: Oduah MT, Iwanowski P Tags: Epilepsy Behav Source Type: research

Digital narrative medicine for the personalization of epilepsy care pathways.
Abstract Among neurological conditions, epilepsy is the disorder best suited to a narrative approach. In epilepsy, the disease, i.e., the condition from the clinical and therapeutic point of view, the illness, the personal experience and impact of the condition, and the sickness, the representations, and social imaginary of epilepsy, are strongly interdependent. Within this context, the Italian League Against Epilepsy (LICE) has launched a multiyear narrative program in Italy resulting in the foundation of a specific Study Group on Narrative Medicine in Epileptology. The Epimena Study is part of this program and i...
Source: Epilepsy and Behaviour - June 15, 2020 Category: Neurology Authors: Cenci C, Mecarelli O Tags: Epilepsy Behav Source Type: research

Usage of antiepileptic drugs in different diseases in Germany - A retrospective study.
CONCLUSIONS: The main indications for which AEDs are prescribed vary with the type of medical practice. The different indications for different AEDs changed between the two time periods, which is in line with the state of the research. PMID: 32554234 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - June 15, 2020 Category: Neurology Authors: Scholten J, Hamer HM, Kostev K Tags: Epilepsy Behav Source Type: research

The role of the epilepsy monitoring unit in the investigation of patients with epilepsy and intellectual disabilities.
CONCLUSIONS: Admission to the EMU provided an accurate characterization of transient events in people with ID and epilepsy with improvement in their medical management. PMID: 32554231 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - June 14, 2020 Category: Neurology Authors: Suller Marti A, Aldosari M, Mirsattari SM Tags: Epilepsy Behav Source Type: research

Neuroticism in temporal lobe epilepsy is associated with altered limbic-frontal lobe resting-state functional connectivity.
Abstract Neuroticism, a core personality trait characterized by a tendency towards experiencing negative affect, has been reported to be higher in people with temporal lobe epilepsy (TLE) compared with healthy individuals. Neuroticism is a known predictor of depression and anxiety, which also occur more frequently in people with TLE. The purpose of this study was to identify abnormalities in whole-brain resting-state functional connectivity in relation to neuroticism in people with TLE and to determine the degree of unique versus shared patterns of abnormal connectivity in relation to elevated symptoms of depressi...
Source: Epilepsy and Behaviour - June 13, 2020 Category: Neurology Authors: Rivera Bonet CN, Hwang G, Hermann B, Struck AF, J Cook C, A Nair V, Mathis J, Allen L, Almane DN, Arkush K, Birn R, Conant LL, DeYoe EA, Felton E, Maganti R, Nencka A, Raghavan M, Shah U, Sosa VN, Ustine C, Prabhakaran V, Binder JR, Meyerand ME Tags: Epilepsy Behav Source Type: research

Time course of drug-related treatment-emergent adverse side effects of brivaracetam.
In this report, we test the hypothesis that drug-related CNS TEAEs have early onset and decrease with time. Unlike prior ASM clinical trials, a novel design was used for brivaracetam (BRV) without initial drug titration allowing assessment of habituation to TEAEs separate from dose titration. METHODS: Data were pooled from three studies (N01252 [NCT00490035], N01253 [NCT00464269], N01358 [NCT01261325]) in adult patients (≥16 years of age) with focal seizures receiving BRV adjunctive therapy. This post hoc analysis reports data on the prevalence and incidence of all drug-related CNS TEAEs and all TEAEs over time i...
Source: Epilepsy and Behaviour - June 13, 2020 Category: Neurology Authors: Meador KJ, Laloyaux C, Elmoufti S, Gasalla T, Fishman J, Martin MS, Klein P Tags: Epilepsy Behav Source Type: research

Epilepsy through the eyes of the media: A paradox of positive reporting and challenges of access to advanced neurotechnology.
Abstract OBJECTIVE: Media coverage of disorders and medical advancements can impact public perception regarding the riskiness, effectiveness, and accessibility of treatment options. We studied that coverage for epilepsy with a focus on surgical interventions and emerging neurotechnologies. METHODS: Epilepsy-related English language articles published through 2019 were retrieved from online International news media with a circulation of 80,000 or above. We used directed content analysis of news articles to code content into a priori categories both to identify salient themes and to characterize their valence. ...
Source: Epilepsy and Behaviour - June 13, 2020 Category: Neurology Authors: Munjal V, Arakelyan M, McDonald PJ, Illes J Tags: Epilepsy Behav Source Type: research

Clinical characteristics of functional (psychogenic nonepileptic) seizures: An international retrospective study.
CONCLUSION: Semiology of functional seizures seems to vary across various regions of the world; socioeconomic, cultural, ethnic, and religious differences may play an essential role in the modulation of functional seizures semiology across different nations and cultures. PMID: 32540770 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - June 12, 2020 Category: Neurology Authors: Asadi-Pooya AA, Brigo F, Mesraoua B, Tarrada A, Karakis I, Hosny H, Alsaadi T, Gigineishvili D, Ali MA, Janocko NJ, Elsheikh L, Hingray C Tags: Epilepsy Behav Source Type: research

Mechanisms and prevention of acid reflux induced laryngospasm in seizing rats.
Abstract OBJECTIVE: Recent animal work and limited clinical data have suggested that laryngospasm may be involved in the cardiorespiratory collapse seen in sudden unexpected death in epilepsy (SUDEP). In previous work, we demonstrated in an animal model of seizures that laryngospasm and sudden death were always preceded by acid reflux into the esophagus. Here, we expand on that work by testing several techniques to prevent the acid reflux or the subsequent laryngospasm. METHODS: In urethane anesthetized Long Evans rats, we used systemic kainic acid to acutely induce seizure activity. We recorded pH in the eso...
Source: Epilepsy and Behaviour - June 12, 2020 Category: Neurology Authors: Budde RB, Pederson DJ, Biggs EN, Jefferys JGR, Irazoqui PP Tags: Epilepsy Behav Source Type: research

Effect of Mozart K.448 on interictal epileptiform discharges in children with epilepsy: A randomized controlled pilot study.
Abstract BACKGROUND: Epilepsy is a common pediatric neurologic disease in Thailand. However, the mainstay antiepileptic pharmacotherapies can induce severe side effects. While the benefit of playing Mozart K.448 music has been studied as an alternative, supplementary, nonpharmacologic treatment for epilepsy, the literature features limited few randomized controlled trial studies of children. OBJECTIVE: We aimed to study the effect of Mozart K.448 for two pianos on interictal epileptiform discharges (IEDs), quantitative electroencephalogram (qEEG), and heart rate variability (HRV) in patients with epilepsy. ...
Source: Epilepsy and Behaviour - June 11, 2020 Category: Neurology Authors: Paprad T, Veeravigrom M, Desudchit T Tags: Epilepsy Behav Source Type: research

Developmental outcomes in children/adolescents and one adult with tuberous sclerosis complex (TSC) and refractory epilepsy treated with everolimus.
Abstract This prospective observational study focuses on developmental outcomes in the treatment of tuberous sclerosis complex (TSC) with everolimus (EVO). Fourteen children/adolescents aged 1.7-13.07 and one adult aged 31 years, all with TSC and refractory epilepsy participated. All were treated with EVO for 3-70 months (md: 37). Development/adaptive functioning were evaluated at baseline with follow-up in 11 patients; all patients were assessed during the course of treatment. Our exploratory analyses included factors contributing to developmental impairment and change from baseline to last evaluation. The ma...
Source: Epilepsy and Behaviour - June 11, 2020 Category: Neurology Authors: Kadish NE, Riedel C, Stephani U, Wiegand G Tags: Epilepsy Behav Source Type: research