Evaluation of anti-seizure medications and their serum concentration with regard to cardiovascular risk parameters: A cross-sectional study
CONCLUSION: In our study, the majority of patients were children and adolescents. Regular monitoring of drug serum concentrations and metabolic parameters may be useful to select the safest drug in terms of cardiovascular disease risk. Randomized controlled trials on the long-term effects of anti-seizure treatment are needed.PMID:38657483 | DOI:10.1016/j.yebeh.2024.109802 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - April 24, 2024 Category: Neurology Authors: Merve Becit-Kizilkaya Seyma Oncu Halit Bugra Koca Dilek Cavusoglu Source Type: research
Cost-effectiveness analysis of HLA-B*15:02 screening before treatment of epilepsy in Indonesia
CONCLUSION: Calculation of the cost-effectiveness of lifetime epilepsy therapy in this study found that the initial screening strategy with the HLA-B*15:02 test was the most cost-effective.PMID:38657484 | DOI:10.1016/j.yebeh.2024.109787 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - April 24, 2024 Category: Neurology Authors: Eric Tanoto Herlyani Khosama Seilly Jehosua Sekplin A S Sekeon Winifred Karema Arthur H P Mawuntu Fima F L G Langi Lim Kheng Seang Source Type: research
Effect of prednisolone in a kindling model of epileptic seizures in rats on cytokine and intestinal microbiota diversity
This study aimed to evaluate the effects of prednisolone treatment on epileptic seizures and investigate the effect of this drug on the bacterial diversity of the intestinal microbiota and markers of inflammatory processes in intestinal tissue. We used Male Wistar rat littermates (n = 31, 90-day-old) divided into four groups: positive control treated with 2 mg/kg of diazepam (n = 6), negative control treated with 0.9 g% sodium chloride (n = 6), and the remaining two groups were subjected to treatment with prednisolone, with one receiving 1 mg/kg (n = 9) and the other 5 mg/kg (n = 10). All administrations were performed int...
Source: Epilepsy and Behaviour - April 24, 2024 Category: Neurology Authors: Amanda Muliterno Domingues Louren ço de Lima Gabriel de Lima Rosa Edson Fernando M üller Guzzo Rafael Bremm Padilha Milena Conci de Araujo Rodrigo Costa da Silva Adriana Simon Coitinho Sueli Teresinha Van Der Sand Source Type: research
Interictal interleukin-6 and tumor necrosis factor α levels are associated with seizure recurrence in adults with epilepsy
CONCLUSION: High levels of IL-6 and TNF-α are associated with a higher possibility of seizure recurrence. Future predictive models should also include inflammatory mediators in addition to clinical variables.PMID:38653175 | DOI:10.1016/j.yebeh.2024.109786 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - April 23, 2024 Category: Neurology Authors: Wenqiang Fang Shihao Chen Xuefen Xia Wenting Huang Yanru Du Zhipeng Liu Lekai Chen Xinshi Wang Huiqin Xu Source Type: research
Interictal interleukin-6 and tumor necrosis factor α levels are associated with seizure recurrence in adults with epilepsy
CONCLUSION: High levels of IL-6 and TNF-α are associated with a higher possibility of seizure recurrence. Future predictive models should also include inflammatory mediators in addition to clinical variables.PMID:38653175 | DOI:10.1016/j.yebeh.2024.109786 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - April 23, 2024 Category: Neurology Authors: Wenqiang Fang Shihao Chen Xuefen Xia Wenting Huang Yanru Du Zhipeng Liu Lekai Chen Xinshi Wang Huiqin Xu Source Type: research
Dravet syndrome seizure frequency and clustering: Placebo-treated patients in clinical trials
Epilepsy Behav. 2024 Apr 20;155:109774. doi: 10.1016/j.yebeh.2024.109774. Online ahead of print.ABSTRACTOBJECTIVE: Dravet syndrome is a rare developmental epilepsy syndrome associated with severe, treatment-resistant seizures. Since seizures and seizure clusters are linked to morbidity, reduced quality of life, and premature mortality, a greater understanding of these outcomes could improve trial designs. This analysis explored seizure types, seizure clusters, and factors affecting seizure cluster variability in Dravet syndrome patients.METHODS: Pooled post-hoc analyses were performed on data from placebo-treated patients ...
Source: Epilepsy and Behaviour - April 21, 2024 Category: Neurology Authors: Rima Nabbout Kerry Hyland Rachael Loftus Charlotte Nortvedt Orrin Devinsky Source Type: research
Current challenges in focal epilepsy treatment: An Italian Delphi consensus
CONCLUSION: The study offered valuable insights into the current state and complexities of managing focal-onset epilepsy. It highlighted many deficiencies in the therapeutic pathway of focal-onset epilepsy in the Italian reality, while it also underscored the importance of patient-centric care, the necessity of early and appropriate intervention, and individualized treatment approaches. The findings also called for continued research, policy development, and healthcare system improvements to enhance epilepsy management, highlighting the ongoing need for tailored healthcare solutions in this evolving field.PMID:38643659 | D...
Source: Epilepsy and Behaviour - April 21, 2024 Category: Neurology Authors: Giancarlo Di Gennaro Simona Lattanzi Oriano Mecarelli Francesco Saverio Mennini Federico Vigevano Source Type: research
Differential relational memory impairment in temporal lobe epilepsy
Epilepsy Behav. 2024 Apr 20;155:109722. doi: 10.1016/j.yebeh.2024.109722. Online ahead of print.ABSTRACTOBJECTIVE: Temporal lobe epilepsy (TLE) is typically associated with pathology of the hippocampus, a key structure involved in relational memory, including episodic, semantic, and spatial memory processes. While it is widely accepted that TLE-associated hippocampal alterations underlie memory deficits, it remains unclear whether impairments relate to a specific cognitive domain or multiple ones.METHODS: We administered a recently validated task paradigm to evaluate episodic, semantic, and spatial memory in 24 pharmacores...
Source: Epilepsy and Behaviour - April 21, 2024 Category: Neurology Authors: Shahin Tavakol Valeria Kebets Jessica Royer Qiongling Li Hans Auer Jordan DeKraker Elizabeth Jefferies Neda Bernasconi Andrea Bernasconi Christoph Helmstaedter Thaera Arafat Jorge Armony R Nathan Spreng Lorenzo Caciagli Birgit Frauscher Jonathan Smallwood Source Type: research
Identifying co-morbidities and risk in people with epilepsy: The Maltese experience
DISCUSSION: Patient outcomes may be improved with increasing rates of personalized epilepsy care plans, appropriate nocturnal surveillance and reducing the prescription of antipsychotic medication as it is associated with greater risk of mortality. Issues such as stigma and shame appear to play a significant role in small communities and their access to care.PMID:38643661 | DOI:10.1016/j.yebeh.2024.109795 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - April 21, 2024 Category: Neurology Authors: Adrian Pace Lance Watkins Daniel Fiott Paul Bassett Richard Laugharne Christopher James Rohit Shankar Source Type: research
Assessment of knowledge towards first aid skills of epilepsy among undergraduate health students in Riyadh province of Saudi Arabia: A cross-sectional study
CONCLUSION: The study concluded that most undergraduate health students demonstrated poor knowledge scores in delivering seizure first aid. This finding suggests that introducing epilepsy education from the first year in all health-related courses is crucial to improving overall awareness and skills in providing seizure first aid.PMID:38643662 | DOI:10.1016/j.yebeh.2024.109788 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - April 21, 2024 Category: Neurology Authors: Abdulrahman M Alshahrani Naif Khalid Alsayed Nemer Alotaibi Mohammad Azhar Rashikh Abdulrahman Talal Alghebaiwi Faisal Faihan Alotaibi Abdulaziz Faisal Alotaibi Abdullah Mohammed Bin Hussain Nawaf Mansour N Alotaibi Mazen Saud Alotaibi Source Type: research
Changes in pediatric referrals after the 2009 ketogenic diet consensus recommendations
CONCLUSIONS: Following the 2009 recommendations, our study shows there was an increase in referrals for children with indications at our center. Referrals from neurologists at our own institution increased the most. Ketogenic diet efficacy improved slightly over time but did not reach significance.PMID:38643663 | DOI:10.1016/j.yebeh.2024.109791 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - April 21, 2024 Category: Neurology Authors: Rebecca S Stainman Zahava Turner Eric H Kossoff Source Type: research
Clinical characteristics of patients with refractory non-epileptic seizures
CONCLUSION: This study provides insight into the features associated with refractory NES and may serve to improve prognostication and management in this disabling condition.PMID:38642527 | DOI:10.1016/j.yebeh.2024.109783 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - April 20, 2024 Category: Neurology Authors: Sarah Fullam Daniel J Costello Source Type: research
Sleep profiles in epilepsy patients undergoing monotherapy and polytherapy: A comparative cross-sectional study
CONCLUSION: Our findings suggest that an increased number of ASMs does not inherently result in a higher incidence of sleep issues. Therefore, multiple ASMs may be prescribed when necessary to achieve improved seizure control. Furthermore, this study underscores the importance of comprehensive management that addresses seizure control and treating affective symptoms in individuals with epilepsy.PMID:38642528 | DOI:10.1016/j.yebeh.2024.109799 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - April 20, 2024 Category: Neurology Authors: Alireza Arvin Morvarid Taebi Zahra Khazaeipour Arezu Najafi Abbas Tafakhori Sakineh Ranji-Bourachaloo Hamed Amirifard Source Type: research
Characterization and quantification of epilepsy patients with hospital episodes in Portugal: A multicenter retrospective study from Liga Portuguesa Contra a Epilepsia
CONCLUSION: This study showed similar results to other European countries. However, due to methodological limitations, a prospective epidemiological study is needed to support this observation. Furthermore, the present study provides a comprehensive picture of hospitalized epilepsy patients in Portugal, their comorbidities, mortality, and hospital procedures.PMID:38642529 | DOI:10.1016/j.yebeh.2024.109771 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - April 20, 2024 Category: Neurology Authors: Carla Bentes Nuno Canas Hugo Pedrosa Jo ão Completo F ábio Pereira Magda Carrilho Jos é Lopes Lima Cristina Pereira Ricardo Rego Helena Rocha Francisca S á Francisco Sales Manuela Santos Rute Teot ónio Source Type: research
Relationships among anxiety, depression, and health-related quality of life in adult epilepsy: A network analysis
CONCLUSION: This study provides new insights into the relationships among anxiety, depression, and HRQoL. Critical central symptoms and bridge symptoms identified in the network might help to quickly identify PWE comorbid anxiety and depression in busy outpatient settings, thereby enabling early intervention and enhancing quality of life.PMID:38640553 | DOI:10.1016/j.yebeh.2024.109748 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - April 19, 2024 Category: Neurology Authors: Hui Song Yuping Zhao Chunmei Hu Chenxiao Zhao Xuefeng Wang Zheng Xiao Source Type: research
