Cognitive and psychiatric adverse events during adjunctive cenobamate treatment in phase 2 and phase 3 clinical studies
CONCLUSIONS: Cognitive and psychiatric TEAEs were reported by similar numbers of cenobamate- and placebo-treated patients during double-blind adjunctive cenobamate treatment (< 4 % of patients), and exposure-adjusted incidence rates of these TEAEs remained low during open-label cenobamate treatment for up to 7 years. Treatment discontinuations due to these TEAEs were rare. The results of this post-hoc analysis indicate that adjunctive cenobamate treatment exhibits a low incidence of cognitive or psychiatric TEAEs in patients with uncontrolled focal seizures.PMID:38184949 | DOI:10.1016/j.yebeh.2023.109605 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - January 7, 2024 Category: Neurology Authors: Gregory L Krauss Steve S Chung Louis Ferrari Sean Stern William E Rosenfeld Source Type: research
Cognitive and psychiatric adverse events during adjunctive cenobamate treatment in phase 2 and phase 3 clinical studies
CONCLUSIONS: Cognitive and psychiatric TEAEs were reported by similar numbers of cenobamate- and placebo-treated patients during double-blind adjunctive cenobamate treatment (< 4 % of patients), and exposure-adjusted incidence rates of these TEAEs remained low during open-label cenobamate treatment for up to 7 years. Treatment discontinuations due to these TEAEs were rare. The results of this post-hoc analysis indicate that adjunctive cenobamate treatment exhibits a low incidence of cognitive or psychiatric TEAEs in patients with uncontrolled focal seizures.PMID:38184949 | DOI:10.1016/j.yebeh.2023.109605 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - January 7, 2024 Category: Neurology Authors: Gregory L Krauss Steve S Chung Louis Ferrari Sean Stern William E Rosenfeld Source Type: research
Transient anticonvulsant effects of time-restricted feeding in the 6-Hz mouse model
CONCLUSIONS: Both continuous and 2:5 TRF regimens transiently increased seizure thresholds in the 6-Hz model at around 2 weeks, which coincided with stability of blood glucose levels during the fed and fasted periods. Our findings suggest that the lack of prolonged anticonvulsant effects in the acute electrical seizure models employed may be attributed to only modest metabolic and antioxidant adaptations found in the brain and liver. Our findings underscore the potential therapeutic value of TRF in managing seizure-related conditions.PMID:38184948 | DOI:10.1016/j.yebeh.2023.109618 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - January 7, 2024 Category: Neurology Authors: Oliver J Armstrong Elliott S Neal Diana Vidovic Weizhi Xu Karin Borges Source Type: research
Effectiveness of CBT for reducing depression and anxiety in people with epilepsy: A systematic review and meta-analysis of randomized controlled trials
CONCLUSION: The result of our study showed that Cognitive behavioral therapy is a superior therapy for treating anxiety and depression in epilepsy patients. CBT was effective in improving Quality of life in patients with epilepsy. However, the sample size varied across the trials, additional high-quality studies are needed in the future.PMID:38183927 | DOI:10.1016/j.yebeh.2023.109608 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - January 6, 2024 Category: Neurology Authors: Neetu Choudhary Ashok Kumar Vaishali Sharma Kirandeep Kaur Parampreet Singh Kharbanda Jitupam Baishya Devender Kumar Akhilesh Sharma Kamalesh Chakravarty Source Type: research
Robotic assessment of sensorimotor and cognitive deficits in patients with temporal lobe epilepsy
Epilepsy Behav. 2024 Jan 5;151:109613. doi: 10.1016/j.yebeh.2023.109613. Online ahead of print.ABSTRACTOBJECTIVE: Individuals with temporal lobe epilepsy (TLE) frequently demonstrate impairments in executive function, working memory, and/or declarative memory. It is recommended that screening for cognitive impairment is undertaken in all people newly diagnosed with epilepsy. However, standard neuropsychological assessments are a limited resource and thus not available to all. Our study investigated the use of robotic technology (the Kinarm robot) for cognitive screening.METHODS: 27 participants with TLE (17 left) underwent...
Source: Epilepsy and Behaviour - January 6, 2024 Category: Neurology Authors: Spencer Finn Theodore Aliyianis Brooke Beattie Lysa Boiss é Lomax Garima Shukla Stephen H Scott Gavin P Winston Source Type: research
Patient-reported outcomes in adults after status epilepticus: A systematic review
The objective of this systematic review was to compile the available information on patient-reported outcomes of adults after status epilepticus. We used Medical Subject Headings terms to search PubMed, Embase, and the Cochrane Library from database inception to February 2023. We excluded reviews, case reports, abstract-only reports, editorials, and publications in languages other than English or French. Studies reporting PROs in adults after SE were eligible. Bias in included studies was assessed using the Newcastle-Ottawa Scale (NOS). Given the heterogeneity in assessment tools and outcomes, most of the results are prese...
Source: Epilepsy and Behaviour - January 6, 2024 Category: Neurology Authors: Gwena ëlle Jacq Candice Fontaine Stephane Legriel Source Type: research
Youtube as a source of information vagal nerve stimulation: A quality analysis
CONCLUSION: Youtube videos may provide a worthful source for patients and parents seeking to find more information about VNS However incorrect information could easily be disseminated by high number of views of videos with low quality. High skilled and experienced professionals should create videos on Youtube to ensure that patients and parents can access more useful, high-quality, and accurate information on VNS.PMID:38181534 | DOI:10.1016/j.yebeh.2023.109597 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - January 5, 2024 Category: Neurology Authors: Aysima Özçelik Cansu Özbaş Ebru Arhan Source Type: research
Epilepsy in dystrophinopathies: A retrospective cohort and review of the literature
This study aimed to assess the prevalence and characteristics of epilepsy in dystrophinopathies within a cohort of 142 patients at a tertiary neuromuscular center in Istanbul, Turkey.METHODS: We recorded the age at seizure onset, seizure type, family history, history of febrile seizures, treatment, and EEG results. Epilepsy was classified according to the latest International League Against Epilepsy (ILAE) classification.RESULTS: Of the 142 DMD patients, 8 experienced epileptic seizures (5.6 %). The median age of the patients was 11 years (8.0-15.2). The median age for the first DMD symptoms was 24 months (16.5-37.5). All ...
Source: Epilepsy and Behaviour - January 5, 2024 Category: Neurology Authors: Özgü Kizek Zuhal Yap ıcı P ınar Topaloğlu Source Type: research
Youtube as a source of information vagal nerve stimulation: A quality analysis
CONCLUSION: Youtube videos may provide a worthful source for patients and parents seeking to find more information about VNS However incorrect information could easily be disseminated by high number of views of videos with low quality. High skilled and experienced professionals should create videos on Youtube to ensure that patients and parents can access more useful, high-quality, and accurate information on VNS.PMID:38181534 | DOI:10.1016/j.yebeh.2023.109597 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - January 5, 2024 Category: Neurology Authors: Aysima Özçelik Cansu Özbaş Ebru Arhan Source Type: research
Epilepsy in dystrophinopathies: A retrospective cohort and review of the literature
This study aimed to assess the prevalence and characteristics of epilepsy in dystrophinopathies within a cohort of 142 patients at a tertiary neuromuscular center in Istanbul, Turkey.METHODS: We recorded the age at seizure onset, seizure type, family history, history of febrile seizures, treatment, and EEG results. Epilepsy was classified according to the latest International League Against Epilepsy (ILAE) classification.RESULTS: Of the 142 DMD patients, 8 experienced epileptic seizures (5.6 %). The median age of the patients was 11 years (8.0-15.2). The median age for the first DMD symptoms was 24 months (16.5-37.5). All ...
Source: Epilepsy and Behaviour - January 5, 2024 Category: Neurology Authors: Özgü Kizek Zuhal Yap ıcı P ınar Topaloğlu Source Type: research
Ambulatory EEG-video
Epilepsy Behav. 2024 Jan 3;151:109615. doi: 10.1016/j.yebeh.2023.109615. Online ahead of print.ABSTRACTHospital based EEG recordings have been the norm to assist in the diagnosis and management of patients with unclassified events and known drug resistant epilepsy. Ambulatory EEG (AEEG) is a tool that comes to serve the needs for a portable testing that can be done at home, often with higher accessibility compared to an epilepsy monitoring unit and with lower cost. The current technology provides good quality EEG tracing and can be done with video when needed. In this review we discuss how AEEG should be performed and the ...
Source: Epilepsy and Behaviour - January 4, 2024 Category: Neurology Authors: Karina A Gonz ález Otárula Stephan Schuele Source Type: research
Ambulatory EEG-video
Epilepsy Behav. 2024 Jan 3;151:109615. doi: 10.1016/j.yebeh.2023.109615. Online ahead of print.ABSTRACTHospital based EEG recordings have been the norm to assist in the diagnosis and management of patients with unclassified events and known drug resistant epilepsy. Ambulatory EEG (AEEG) is a tool that comes to serve the needs for a portable testing that can be done at home, often with higher accessibility compared to an epilepsy monitoring unit and with lower cost. The current technology provides good quality EEG tracing and can be done with video when needed. In this review we discuss how AEEG should be performed and the ...
Source: Epilepsy and Behaviour - January 4, 2024 Category: Neurology Authors: Karina A Gonz ález Otárula Stephan Schuele Source Type: research
Diagnosis, epilepsy treatment and supports for neurodevelopment in children with Dravet Syndrome: Caregiver reported experiences and needs
CONCLUSION: The responses of caregivers of children with Dravet syndrome highlight the need for supports from diagnosis for both epilepsy and neurodevelopmental problems. Good examples of provision were identified but parents often felt they lacked support and support often came from providers who lacked knowledge of the syndrome. Collaboration between medical, disability and school services was often lacking.PMID:38168600 | DOI:10.1016/j.yebeh.2023.109603 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - January 3, 2024 Category: Neurology Authors: Josefin Soto Jansson Bj örn Bjurulf Michaela Dellenmark Blom Tove Hallb öök Colin Reilly Source Type: research
Feasibility of mobile phone application "Epilepsy care" for self-management of children and adolescents with epilepsy in Phramongkutklao hospital: A randomized controlled trial
Epilepsy Behav. 2023 Dec 31;151:109598. doi: 10.1016/j.yebeh.2023.109598. Online ahead of print.ABSTRACTEpilepsy is a common neurological disorder in children. Mobile applications have shown potential in improving self-management for patients with chronic illnesses. To address language barriers, we developed the first Thai version of the "Epilepsy care" mobile application for children and adolescents with epilepsy in Thailand. A prospective, randomized controlled trial with 220 children and adolescents living with epilepsy who had a smartphone and were treated at the pediatric neurology clinic was conducted, with one group...
Source: Epilepsy and Behaviour - January 1, 2024 Category: Neurology Authors: Pantira Chinsuwan Wilawan W Wilodjananunt Dittaya Wanvarie Nithipun Suksumek Kullasate Sakpichaisakul Thitiwan Simasathien Charcrin Nabangchang Piradee Suwanpakdee Source Type: research
Feasibility of mobile phone application "Epilepsy care" for self-management of children and adolescents with epilepsy in Phramongkutklao hospital: A randomized controlled trial
Epilepsy Behav. 2023 Dec 31;151:109598. doi: 10.1016/j.yebeh.2023.109598. Online ahead of print.ABSTRACTEpilepsy is a common neurological disorder in children. Mobile applications have shown potential in improving self-management for patients with chronic illnesses. To address language barriers, we developed the first Thai version of the "Epilepsy care" mobile application for children and adolescents with epilepsy in Thailand. A prospective, randomized controlled trial with 220 children and adolescents living with epilepsy who had a smartphone and were treated at the pediatric neurology clinic was conducted, with one group...
Source: Epilepsy and Behaviour - January 1, 2024 Category: Neurology Authors: Pantira Chinsuwan Wilawan W Wilodjananunt Dittaya Wanvarie Nithipun Suksumek Kullasate Sakpichaisakul Thitiwan Simasathien Charcrin Nabangchang Piradee Suwanpakdee Source Type: research
