CBD treatment following early life seizures alters orbitofrontal-striatal signaling during adulthood
Epilepsy Behav. 2024 Feb 6;152:109638. doi: 10.1016/j.yebeh.2024.109638. Online ahead of print.ABSTRACTObsessive compulsive disorder (OCD) is a comorbid condition of epilepsy and often adds to the burden of epilepsy. Both OCD and epilepsy are disorders of hyperexcitable circuits. Fronto-striatal circuit dysfunction is implicated in OCD. Prior work in our laboratory has shown that in rat pups following a series of flurothyl-induced early life seizures (ELS) exhibit frontal-lobe dysfunction along with alterations in electrographic temporal coordination between the orbitofrontal cortex (OFC) and dorsomedial striatum (DMS), ci...
Source: Epilepsy and Behaviour - February 7, 2024 Category: Neurology Authors: Natalie A Cashen Michelle L Kloc Davi Pressman Samuel A Liebman Gregory L Holmes Source Type: research
Quality of life in people with epilepsy: The associations of anti-seizure medications and biopsychosocial variables
This study examined the associations between specific anti-seizure medications, biopsychosocial factors, and QOL in people with epilepsy. Analysis of covariance revealed that individuals taking three or more anti-seizure medications had significantly lower QOL than those taking levetiracetam. Findings also demonstrated that when examining biopsychosocial factors as predictors of QOL in hierarchical regression, anxiety, depression, and daytime sleepiness were significant predictors of QOL. Once these factors were entered into the model, number of medications was no longer significant. The final model predicted 59.6% of the ...
Source: Epilepsy and Behaviour - February 6, 2024 Category: Neurology Authors: Julia A Thomas Nicole M Ditchman Leslie Guidotti Breting Jaishree Narayanan Source Type: research
How do children with focal epilepsies perceive the moment they realize that they are about to have a seizure? A pilot study
CONCLUSION: Children who perceive in advance that they are about to have a seizure are well able to describe their experience. Most children take measures to manage their seizures. Those measures were regarded as helpful by most children with other focal epilepsies, but by no child with SELECTs. Larger studies are necessary to determine the factors contributing to the child's perception as well as the nature of the support that they require.PMID:38306740 | DOI:10.1016/j.yebeh.2024.109663 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - February 2, 2024 Category: Neurology Authors: Sarah Jeschke Mathilda Charisius Sarah Lange Thilo Bertsche Phoebe Makiello Martina P Neininger Astrid Bertsche Source Type: research
Elevated phase amplitude coupling as a depression biomarker in epilepsy
Epilepsy Behav. 2024 Jan 31;152:109659. doi: 10.1016/j.yebeh.2024.109659. Online ahead of print.ABSTRACTDepression is prevalent in epilepsy patients and their intracranial brain activity recordings can be used to determine the types of brain activity that are associated with comorbid depression. We performed case-control comparison of spectral power and phase amplitude coupling (PAC) in 34 invasively monitored drug resistant epilepsy patients' brain recordings. The values of spectral power and PAC for one-minute segments out of every hour in a patient's study were correlated with pre-operative assessment of depressive symp...
Source: Epilepsy and Behaviour - February 1, 2024 Category: Neurology Authors: James J Young Andy Ho Wing Chan Nathalie Jette Heidi A Bender Adam E Saad Ignacio Saez Fedor Panov Saadi Ghatan Ji Yeoun Yoo Anuradha Singh Madeline C Fields Lara V Marcuse Helen S Mayberg Source Type: research
The crosstalk between epilepsy and dementia: A systematic review and meta-analysis
CONCLUSIONS: There are still gaps in epidemiology regarding the correlation between dementia types and epilepsy, vascular risk factors, and the impact of antiseizure medication or cognitive improvement drugs on epilepsy and AD comorbidity.PMID:38301455 | DOI:10.1016/j.yebeh.2024.109640 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - February 1, 2024 Category: Neurology Authors: Lu Chen Wenqian Yang Fei Yang Yanying Yu Tingwan Xu Dan Wang Qingqing Zhao Qian Wu Yanbing Han Source Type: research
Development and construction of the Multidimensional Self-Efficacy Scale for Epilepsy (MSESE) and its psychometric properties
CONCLUSIONS: The MSESE is a convenient, multidimensional, and easy-to-use scale with good psychometric properties, making it suitable for both clinical assessments and research purposes.PMID:38301456 | DOI:10.1016/j.yebeh.2024.109667 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - February 1, 2024 Category: Neurology Authors: Che-Wei Lin Hsiang-Yu Yu Chien-Chen Chou Ren-Hau Li Yi-Jiun Lu Wei-Han Wang Source Type: research
Association between cognitive impairment and antiseizure medication adherence among people with epilepsy in Addis Ababa, Ethiopia
CONCLUSIONS: There is a high rate of cognitive impairment and non-adherence to ASMs in PWE living in Addis Ababa, Ethiopia. Poor ASM adherence is a possible risk factor for cognitive impairment. PWE can benefit from interventions to improve ASM adherence, physical exercise, and better educational attainment.PMID:38295505 | DOI:10.1016/j.yebeh.2024.109651 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - January 31, 2024 Category: Neurology Authors: Blen Mamo Anteneh M Feyissa Tariku Mengesha Biniyam A Ayele Yared Mamushet Yifru Source Type: research
Management of patients with epilepsy and Intellectual disabilities in group homes vs. Family Homes: Insights into polypharmacy and seizure characteristics
This study aimed to investigate the differences in ASMs prescription, seizure characteristics and predictors of polypharmacy in patients with epilepsy and Intellectual disabilities (IDs) residing in group homes versus family homes.METHODS: This nine-year retrospective study analyzed patients with epilepsy and IDs who were admitted to the EMU, epilepsy clinics at LHSC and rehabilitation clinics for patients with IDs at Parkwood Institution. The study included individuals aged 16 years and older residing in either group homes or family homes. Data on demographics, epilepsy characteristics, and ASMs use were collected and ana...
Source: Epilepsy and Behaviour - January 31, 2024 Category: Neurology Authors: Norah A ALKhaldi Michelle Tu Ana Suller Marti Azra Zafar Christine Le Derek Debicki Seyed M Mirsattari Source Type: research
Efficacy and safety of agomelatine in epilepsy patients with sleep and mood disorders: An observational, retrospective cohort study
Epilepsy Behav. 2024 Jan 28;152:109641. doi: 10.1016/j.yebeh.2024.109641. Online ahead of print.ABSTRACTOBJECTIVE: To evaluate the therapeutic efficacy and safety of agomelatine for treating the sleep and mood disorders in epilepsy patients.METHODS: Retrospective data were derived from 113 epilepsy patients for at least 8 weeks. All the subjects were divided into two groups, one was treated with agomelatine, the other was treated with escitalopram. Their depression and anxiety states were assessed by Hamilton Depression (HAMD) and Hamilton Anxiety (HAMA) Scales. Sleep quality was assessed by the Pittsburgh Sleep Quality In...
Source: Epilepsy and Behaviour - January 29, 2024 Category: Neurology Authors: Jing Jiang Yu-Jiao Wu Cui-Hua Yan Yang Jin Ting-Ting Yang Tao Han Xue-Wu Liu Source Type: research
Structural and functional changes associated with functional/dissociative seizures: A review of the literature
CONCLUSION: The contribution of neuroimaging may allow a more precise explanation of the disorder for patients, avoiding the stigma frequently associated with this diagnosis. as with other 'conversion' phenomena which have traditionally been considered only as 'medically unexplained'. In the longer term and beyond a better understanding of the physiopathology of the disorder, the challenge of this neuroimaging work would be to identify specific imaging biomarkers for a diagnosis of FDS.PMID:38281393 | DOI:10.1016/j.yebeh.2024.109654 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - January 28, 2024 Category: Neurology Authors: Johann Hassan Simon Taib Antoine Yrondi Source Type: research
Historical roots of the stigma of epilepsy: A review of the classic Iranian literature
CONCLUSIONS: Classic Persian literature considered epilepsy as a simile for suffering and a sign of insanity that is caused by blasphemous beliefs or celestial objects, with PWE classified as insane and unwise. While such depictions became less prevalent after the 14th century CE, they can give rise to misconceptions and negative stigma toward PWE and should be addressed in modern culture. Each society should critically investigate its socio-cultural origins of stigma and rectify such misbeliefs.PMID:38280255 | DOI:10.1016/j.yebeh.2024.109644 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - January 27, 2024 Category: Neurology Authors: Mohsen Farjoud Kouhanjani Seyed Ali Hosseini Ali A Asadi-Pooya Mojtaba Heydari Seyed Mohammad Hadi Hosseini Hakimeh Khatoon Farjoudi Kouhanjani Source Type: research
Dual diagnosis of epilepsy and dissociative seizures: Prescription patterns, feasibility and safety of rationalising antiseizure medication
CONCLUSIONS: Clinicians should consider the development of co-morbid DS in patients with epilepsy not responding to an escalation of ASM, especially if presenting with a new seizure type. Patients with a dual-diagnosis of epilepsy and DS, particularly those with well controlled epilepsy, are likely overtreated with ASM. Medication review in a tertiary epilepsy centre allows for safe rationalisation of ASM and likely contributes to the need for fewer hospital attendances.PMID:38277845 | DOI:10.1016/j.yebeh.2024.109661 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - January 26, 2024 Category: Neurology Authors: Andrew Whitfield Emma Leighton Heather Boagey Maria Oto Source Type: research
The mediating role of social support in the relationship between psychosocial problems and sleep patterns of adolescents with epilepsy
CONCLUSIONS: It was found that social support was not a mediator in the relationship between psychosocial problems of adolescents with epilepsy and their sleep status.PMID:38277846 | DOI:10.1016/j.yebeh.2024.109656 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - January 26, 2024 Category: Neurology Authors: Mehmet Emin D üken M ürşide Zengin Source Type: research
Psychiatric comorbidity in people with epilepsy in Ethiopia: Systematic review and meta-analysis
CONCLUSIONS: This systematic review and meta-analysis revealed that the pooled prevalence of psychiatric comorbidity among people with epilepsy was found to be higher compared with the general population. Therefore, among people with epilepsy, parallel psychiatric evaluation is very important along with neurological evaluation.PMID:38277847 | DOI:10.1016/j.yebeh.2024.109648 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - January 26, 2024 Category: Neurology Authors: Techilo Tinsae Shegaye Shumet Mamaru Melkam Tesfaye Segon Girmaw Medfu Takelle Gidey Rtbey Girum Nakie Setegn Fentahun Fantahun Andualem Wondale Getinet Source Type: research
Efficacy and safety of six new antiseizure medications for adjunctive treatment of focal epilepsy and epileptic syndrome: A systematic review and network meta-analysis
CONCLUSIONS: This NMA indicated that the most effective treatment strategy for focal epilepsy, DS, Lennox-Gastaut syndrome, and TSC, respectively, included CBM 300 mg, FFM, CBD, and ELM. However, the aforementioned findings need further confirmation.PMID:38277848 | DOI:10.1016/j.yebeh.2024.109653 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - January 26, 2024 Category: Neurology Authors: Jingyi Tong Tingting Ji Ting Liu Jiaqi Liu Yibin Chen Zongjun Li Na Lu Qifu Li Source Type: research
