Cellular senescence in reproduction: a two-edged sword †
Biol Reprod. 2024 Mar 13:ioae025. doi: 10.1093/biolre/ioae025. Online ahead of print.ABSTRACTCellular senescence (CS) is the state when cells are no longer capable to divide even after stimulation with grown factors. Cells that begin to undergo CS stop in the cell cycle and enter a suspended state without committing to programmed cell death. These cells assume a specific phenotype and influence their microenvironment by secreting molecules and extracellular vesicles that are part of the so-called senescent cell-associated secretory phenotype (SASP). Cellular senescence is intertwined with physiological and pathological con...
Source: Biology of Reproduction - March 14, 2024 Category: Reproduction Medicine Authors: Luiza Pretto Eduarda Nabinger Eduardo Cremonesi Filippi-Chiela Lucas Rosa Fraga Source Type: research
Cellular senescence in reproduction: a two-edged sword †
Biol Reprod. 2024 Mar 13:ioae025. doi: 10.1093/biolre/ioae025. Online ahead of print.ABSTRACTCellular senescence (CS) is the state when cells are no longer capable to divide even after stimulation with grown factors. Cells that begin to undergo CS stop in the cell cycle and enter a suspended state without committing to programmed cell death. These cells assume a specific phenotype and influence their microenvironment by secreting molecules and extracellular vesicles that are part of the so-called senescent cell-associated secretory phenotype (SASP). Cellular senescence is intertwined with physiological and pathological con...
Source: Biology of Reproduction - March 14, 2024 Category: Reproduction Medicine Authors: Luiza Pretto Eduarda Nabinger Eduardo Cremonesi Filippi-Chiela Lucas Rosa Fraga Source Type: research
Cellular senescence in reproduction: a two-edged sword †
Biol Reprod. 2024 Mar 13:ioae025. doi: 10.1093/biolre/ioae025. Online ahead of print.ABSTRACTCellular senescence (CS) is the state when cells are no longer capable to divide even after stimulation with grown factors. Cells that begin to undergo CS stop in the cell cycle and enter a suspended state without committing to programmed cell death. These cells assume a specific phenotype and influence their microenvironment by secreting molecules and extracellular vesicles that are part of the so-called senescent cell-associated secretory phenotype (SASP). Cellular senescence is intertwined with physiological and pathological con...
Source: Biology of Reproduction - March 14, 2024 Category: Reproduction Medicine Authors: Luiza Pretto Eduarda Nabinger Eduardo Cremonesi Filippi-Chiela Lucas Rosa Fraga Source Type: research
Correction to: Activation of HAND2-FGFR signaling pathway by lncRNA HAND2-AS1 in adenomyosis
Biol Reprod. 2024 Mar 13:ioae037. doi: 10.1093/biolre/ioae037. Online ahead of print.NO ABSTRACTPMID:38477360 | DOI:10.1093/biolre/ioae037 (Source: Biology of Reproduction)
Source: Biology of Reproduction - March 13, 2024 Category: Reproduction Medicine Source Type: research
4D label-free quantitative proteomic analysis identifies CRABP1 as a novel candidate gene for litter size in rabbits
Biol Reprod. 2024 Mar 13:ioae038. doi: 10.1093/biolre/ioae038. Online ahead of print.ABSTRACTIn commercial rabbit breeding, litter size is a crucial reproductive trait. This trait directly determines the reproductive ability of female rabbits and is crucial for evaluating the production efficiency. We here compared differentially expressed proteins of in the ovary tissue from New Zealand female rabbits with high (H) and low (L) litter sizes by using 4D label-free quantitative proteomic technology and identified 92 differential proteins. The biological functions of these proteins were revealed through gene ontology (GO) and...
Source: Biology of Reproduction - March 13, 2024 Category: Reproduction Medicine Authors: Zhiyuan Bao Yang Chen Jiali Li Jiawei Cai Jie Yang Pin Zhai Bohao Zhao Xinsheng Wu Source Type: research
Correction to: Activation of HAND2-FGFR signaling pathway by lncRNA HAND2-AS1 in adenomyosis
Biol Reprod. 2024 Mar 13:ioae037. doi: 10.1093/biolre/ioae037. Online ahead of print.NO ABSTRACTPMID:38477360 | DOI:10.1093/biolre/ioae037 (Source: Biology of Reproduction)
Source: Biology of Reproduction - March 13, 2024 Category: Reproduction Medicine Source Type: research
4D label-free quantitative proteomic analysis identifies CRABP1 as a novel candidate gene for litter size in rabbits
Biol Reprod. 2024 Mar 13:ioae038. doi: 10.1093/biolre/ioae038. Online ahead of print.ABSTRACTIn commercial rabbit breeding, litter size is a crucial reproductive trait. This trait directly determines the reproductive ability of female rabbits and is crucial for evaluating the production efficiency. We here compared differentially expressed proteins of in the ovary tissue from New Zealand female rabbits with high (H) and low (L) litter sizes by using 4D label-free quantitative proteomic technology and identified 92 differential proteins. The biological functions of these proteins were revealed through gene ontology (GO) and...
Source: Biology of Reproduction - March 13, 2024 Category: Reproduction Medicine Authors: Zhiyuan Bao Yang Chen Jiali Li Jiawei Cai Jie Yang Pin Zhai Bohao Zhao Xinsheng Wu Source Type: research
The role of the indoleamine 2,3-dioxygenase gene in preventing ovarian transplant rejection in rats
Biol Reprod. 2024 Mar 7:ioae036. doi: 10.1093/biolre/ioae036. Online ahead of print.ABSTRACTIndoleamine 2, 3-dioxygenase (IDO) plays important roles in maternal immune tolerance. Female Sprague Dawley rats (9-11 weeks old) were randomly divided into an autoplastic transplantation group (n = 75) and an allograft transplantation group (n = 300) further divided into subgroups of ovarian transplantation, allograft ovarian transplantation, allograft ovarian transplantation with cyclosporine A treatment, allograft ovarian transplantation and transfection with IDO-expressing lentiviruses, and allograft ovarian transplantation and...
Source: Biology of Reproduction - March 7, 2024 Category: Reproduction Medicine Authors: Aizhuan Long Shuyun Zhao Guanyou Huang Xiaoying Li Hui Cheng Zengchunxiao Chen Zhu Hu Leilei Zhu Danqing Zhao Xiaoyan Hu Jun Wang Source Type: research
The role of the indoleamine 2,3-dioxygenase gene in preventing ovarian transplant rejection in rats
Biol Reprod. 2024 Mar 7:ioae036. doi: 10.1093/biolre/ioae036. Online ahead of print.ABSTRACTIndoleamine 2, 3-dioxygenase (IDO) plays important roles in maternal immune tolerance. Female Sprague Dawley rats (9-11 weeks old) were randomly divided into an autoplastic transplantation group (n = 75) and an allograft transplantation group (n = 300) further divided into subgroups of ovarian transplantation, allograft ovarian transplantation, allograft ovarian transplantation with cyclosporine A treatment, allograft ovarian transplantation and transfection with IDO-expressing lentiviruses, and allograft ovarian transplantation and...
Source: Biology of Reproduction - March 7, 2024 Category: Reproduction Medicine Authors: Aizhuan Long Shuyun Zhao Guanyou Huang Xiaoying Li Hui Cheng Zengchunxiao Chen Zhu Hu Leilei Zhu Danqing Zhao Xiaoyan Hu Jun Wang Source Type: research
The role of the indoleamine 2,3-dioxygenase gene in preventing ovarian transplant rejection in rats
Biol Reprod. 2024 Mar 7:ioae036. doi: 10.1093/biolre/ioae036. Online ahead of print.ABSTRACTIndoleamine 2, 3-dioxygenase (IDO) plays important roles in maternal immune tolerance. Female Sprague Dawley rats (9-11 weeks old) were randomly divided into an autoplastic transplantation group (n = 75) and an allograft transplantation group (n = 300) further divided into subgroups of ovarian transplantation, allograft ovarian transplantation, allograft ovarian transplantation with cyclosporine A treatment, allograft ovarian transplantation and transfection with IDO-expressing lentiviruses, and allograft ovarian transplantation and...
Source: Biology of Reproduction - March 7, 2024 Category: Reproduction Medicine Authors: Aizhuan Long Shuyun Zhao Guanyou Huang Xiaoying Li Hui Cheng Zengchunxiao Chen Zhu Hu Leilei Zhu Danqing Zhao Xiaoyan Hu Jun Wang Source Type: research
The role of the indoleamine 2,3-dioxygenase gene in preventing ovarian transplant rejection in rats
Biol Reprod. 2024 Mar 7:ioae036. doi: 10.1093/biolre/ioae036. Online ahead of print.ABSTRACTIndoleamine 2, 3-dioxygenase (IDO) plays important roles in maternal immune tolerance. Female Sprague Dawley rats (9-11 weeks old) were randomly divided into an autoplastic transplantation group (n = 75) and an allograft transplantation group (n = 300) further divided into subgroups of ovarian transplantation, allograft ovarian transplantation, allograft ovarian transplantation with cyclosporine A treatment, allograft ovarian transplantation and transfection with IDO-expressing lentiviruses, and allograft ovarian transplantation and...
Source: Biology of Reproduction - March 7, 2024 Category: Reproduction Medicine Authors: Aizhuan Long Shuyun Zhao Guanyou Huang Xiaoying Li Hui Cheng Zengchunxiao Chen Zhu Hu Leilei Zhu Danqing Zhao Xiaoyan Hu Jun Wang Source Type: research
The role of the indoleamine 2,3-dioxygenase gene in preventing ovarian transplant rejection in rats
Biol Reprod. 2024 Mar 7:ioae036. doi: 10.1093/biolre/ioae036. Online ahead of print.ABSTRACTIndoleamine 2, 3-dioxygenase (IDO) plays important roles in maternal immune tolerance. Female Sprague Dawley rats (9-11 weeks old) were randomly divided into an autoplastic transplantation group (n = 75) and an allograft transplantation group (n = 300) further divided into subgroups of ovarian transplantation, allograft ovarian transplantation, allograft ovarian transplantation with cyclosporine A treatment, allograft ovarian transplantation and transfection with IDO-expressing lentiviruses, and allograft ovarian transplantation and...
Source: Biology of Reproduction - March 7, 2024 Category: Reproduction Medicine Authors: Aizhuan Long Shuyun Zhao Guanyou Huang Xiaoying Li Hui Cheng Zengchunxiao Chen Zhu Hu Leilei Zhu Danqing Zhao Xiaoyan Hu Jun Wang Source Type: research
Magnetic resonance imaging of placental Intralobule structure and function in a pre-clinical nonhuman primate model
Biol Reprod. 2024 Mar 5:ioae035. doi: 10.1093/biolre/ioae035. Online ahead of print.ABSTRACTThe placenta has a critical role in delivery of oxygen and an array of nutrients, hormones, antibodies and other biochemicals to the fetus, as well as the elimination of carbon dioxide and other waste products from the fetal circulation. Interrogating placental function is therefore essential for assessment of fetal and maternal health during gestation. Although the central role of adequate blood flow and oxygen delivery is clear, the lack of optimized imaging modalities to study placental structure has impeded our understanding of ...
Source: Biology of Reproduction - March 5, 2024 Category: Reproduction Medicine Authors: Andrew Melbourne Matthias C Schabel Anna L David Victoria H J Roberts Source Type: research
Magnetic resonance imaging of placental Intralobule structure and function in a pre-clinical nonhuman primate model
Biol Reprod. 2024 Mar 5:ioae035. doi: 10.1093/biolre/ioae035. Online ahead of print.ABSTRACTThe placenta has a critical role in delivery of oxygen and an array of nutrients, hormones, antibodies and other biochemicals to the fetus, as well as the elimination of carbon dioxide and other waste products from the fetal circulation. Interrogating placental function is therefore essential for assessment of fetal and maternal health during gestation. Although the central role of adequate blood flow and oxygen delivery is clear, the lack of optimized imaging modalities to study placental structure has impeded our understanding of ...
Source: Biology of Reproduction - March 5, 2024 Category: Reproduction Medicine Authors: Andrew Melbourne Matthias C Schabel Anna L David Victoria H J Roberts Source Type: research
Deubiquitylase USP7 plays a crucial role in the lineage differentiation of preimplantation blastocysts
In conclusion, our results suggest that USP7 may play a crucial role in preimplantation embryonic development by regulating lineage differentiation and key epigenetic modifications.PMID:38438135 | DOI:10.1093/biolre/ioae034 (Source: Biology of Reproduction)
Source: Biology of Reproduction - March 4, 2024 Category: Reproduction Medicine Authors: Tong Yu Xinyi Zhao Yujie Tang Yingbing Zhang Bozhen Ji Weijia Song Jianmin Su Source Type: research