AKAP3 mediated type I PKA Signaling is required for mouse sperm Hyperactivation and fertility
Biol Reprod. 2023 Dec 25:ioad180. doi: 10.1093/biolre/ioad180. Online ahead of print.ABSTRACTProtein kinase A (PKA) signaling pathway which mediated protein phosphorylation is important for sperm motility and male fertility. This process relies on A-kinase anchoring proteins (AKAPs) that organize PKA and its signalosomes within specific subcellular compartments. Previously, it was found that the absence of AKAP3 leads to multiple morphological abnormalities in mouse sperm. But how AKAP3 regulates sperm motility is yet to be elucidated. AKAP3 has two amphipathic domains, Dual and RI in its N-terminus. These domains are resp...
Source: Biology of Reproduction - December 25, 2023 Category: Reproduction Medicine Authors: Zhongkun Liang Chaowei Dai Fenfen He Yu Wang Yihua Huang Heying Li Yongming Wu Yafang Hu Kaibiao Xu Source Type: research
Pathological shifts in tryptophan metabolism in human term placenta exposed to LPS or poly I:C
This study evaluates the effect of bacterial (LPS) and viral (poly I:C) placental infection on TRP metabolism using an ex vivo model. Human placenta explants were exposed to LPS or Poly I:C, and the release of TRP metabolites was analyzed together with the expression of related genes and proteins and the functional activity of key enzymes in TRP metabolism. The rate-limiting enzyme in the serotonin pathway, tryptophan hydroxylase, showed reduced expression and functional activity in explants exposed to LPS or Poly I:C. Conversely, the rate-limiting enzyme in the kynurenine (KYN) pathway, indoleamine dioxygenase, exhibited ...
Source: Biology of Reproduction - December 25, 2023 Category: Reproduction Medicine Authors: Cilia Abad Rona Karahoda Anna Orbisova Petr Kastner Heblik Daniel Radim Kucera Ramon Portillo Frantisek Staud Source Type: research
Vitamin D3 promotes fish oocyte development by directly regulating gonadal steroid hormone synthesis
In conclusion, this study shows that an appropriate concentration of VD3 can promote zebrafish ovarian development and affect VTG synthesis through the vdr/cyp19a1a/er/vtg gene axis.PMID:38145497 | DOI:10.1093/biolre/ioad176 (Source: Biology of Reproduction)
Source: Biology of Reproduction - December 25, 2023 Category: Reproduction Medicine Authors: Gang Yang Ke Cheng Yanqing Huang Chunfang Wang Source Type: research
Long non-coding RNAs: a summary of their roles in placenta development and pathology
Biol Reprod. 2023 Dec 22:ioad179. doi: 10.1093/biolre/ioad179. Online ahead of print.ABSTRACTLong non-coding RNAs (lncRNAs) are cellular transcripts that have more than 200 nucleotides in length and do not code for proteins. Due to their low expression levels, lncRNAs were previously considered as mere transcriptional noise. However, current evidence indicates that they regulate a myriad of biological processes such as cell proliferation, invasion, and apoptosis. Hence, their expression patterns are crucial indicators of the physiological or pathological states of cells, tissues, and organs. The utilization of lncRNAs as b...
Source: Biology of Reproduction - December 22, 2023 Category: Reproduction Medicine Authors: Enoch Appiah Adu-Gyamfi Elisha Ann Cheeran Joudi Salamah Divine Blessing Enabulele Ayesha Tahir Bum-Kyu Lee Source Type: research
BKCa channels are involved in spontaneous and LPS-stimulated uterine contraction in late gestation mice
Biol Reprod. 2023 Dec 22:ioad174. doi: 10.1093/biolre/ioad174. Online ahead of print.ABSTRACTThe large-conductance, voltage-gated, calcium (Ca2+)-activated potassium channel (BKCa) is one of the most abundant potassium channels in the myometrium. Previous work conducted by our group has identified a link between inflammation, BKCa channels and excitability of myometrial smooth muscle cells. Here we investigate the role of BKCa channels in spontaneous and lipopolysaccharide (LPS)-stimulated uterine contraction to gain a better understanding of the relationship between the BKCa channel and uterine contraction in basal and in...
Source: Biology of Reproduction - December 22, 2023 Category: Reproduction Medicine Authors: Junjie Bao Xiaofeng Ma Lindsey N Kent Monali Wakle-Prabagaran Ronald McCarthy Sarah K England Source Type: research
The role of the aryl hydrocarbon receptor in mediating the effects of mono(2-ethylhexyl) phthalate in mouse ovarian antral follicles
Biol Reprod. 2023 Dec 22:ioad178. doi: 10.1093/biolre/ioad178. Online ahead of print.ABSTRACTDi(2-ethylhexyl) phthalate (DEHP) is a pervasive environmental toxicant used in the manufacturing of numerous consumer products, medical supplies, and building materials. DEHP is metabolized to mono(2-ethylhexyl) phthalate (MEHP). MEHP is an endocrine disruptor that adversely affects folliculogenesis and steroidogenesis in the ovary, but its mechanism of action is not fully understood. Thus, we tested the hypothesis that the aryl hydrocarbon receptor (AHR) plays a functional role in MEHP-mediated disruption of folliculogenesis and ...
Source: Biology of Reproduction - December 22, 2023 Category: Reproduction Medicine Authors: Alison M Neff Zane Inman Vasiliki E Mourikes Rams és Santacruz-Márquez Andressa Gonsioroski Mary J Laws Jodi A Flaws Source Type: research
Long non-coding RNAs: a summary of their roles in placenta development and pathology
Biol Reprod. 2023 Dec 22:ioad179. doi: 10.1093/biolre/ioad179. Online ahead of print.ABSTRACTLong non-coding RNAs (lncRNAs) are cellular transcripts that have more than 200 nucleotides in length and do not code for proteins. Due to their low expression levels, lncRNAs were previously considered as mere transcriptional noise. However, current evidence indicates that they regulate a myriad of biological processes such as cell proliferation, invasion, and apoptosis. Hence, their expression patterns are crucial indicators of the physiological or pathological states of cells, tissues, and organs. The utilization of lncRNAs as b...
Source: Biology of Reproduction - December 22, 2023 Category: Reproduction Medicine Authors: Enoch Appiah Adu-Gyamfi Elisha Ann Cheeran Joudi Salamah Divine Blessing Enabulele Ayesha Tahir Bum-Kyu Lee Source Type: research
BKCa channels are involved in spontaneous and LPS-stimulated uterine contraction in late gestation mice
Biol Reprod. 2023 Dec 22:ioad174. doi: 10.1093/biolre/ioad174. Online ahead of print.ABSTRACTThe large-conductance, voltage-gated, calcium (Ca2+)-activated potassium channel (BKCa) is one of the most abundant potassium channels in the myometrium. Previous work conducted by our group has identified a link between inflammation, BKCa channels and excitability of myometrial smooth muscle cells. Here we investigate the role of BKCa channels in spontaneous and lipopolysaccharide (LPS)-stimulated uterine contraction to gain a better understanding of the relationship between the BKCa channel and uterine contraction in basal and in...
Source: Biology of Reproduction - December 22, 2023 Category: Reproduction Medicine Authors: Junjie Bao Xiaofeng Ma Lindsey N Kent Monali Wakle-Prabagaran Ronald McCarthy Sarah K England Source Type: research
The role of the aryl hydrocarbon receptor in mediating the effects of mono(2-ethylhexyl) phthalate in mouse ovarian antral follicles
Biol Reprod. 2023 Dec 22:ioad178. doi: 10.1093/biolre/ioad178. Online ahead of print.ABSTRACTDi(2-ethylhexyl) phthalate (DEHP) is a pervasive environmental toxicant used in the manufacturing of numerous consumer products, medical supplies, and building materials. DEHP is metabolized to mono(2-ethylhexyl) phthalate (MEHP). MEHP is an endocrine disruptor that adversely affects folliculogenesis and steroidogenesis in the ovary, but its mechanism of action is not fully understood. Thus, we tested the hypothesis that the aryl hydrocarbon receptor (AHR) plays a functional role in MEHP-mediated disruption of folliculogenesis and ...
Source: Biology of Reproduction - December 22, 2023 Category: Reproduction Medicine Authors: Alison M Neff Zane Inman Vasiliki E Mourikes Rams és Santacruz-Márquez Andressa Gonsioroski Mary J Laws Jodi A Flaws Source Type: research
Long non-coding RNAs: a summary of their roles in placenta development and pathology
Biol Reprod. 2023 Dec 22:ioad179. doi: 10.1093/biolre/ioad179. Online ahead of print.ABSTRACTLong non-coding RNAs (lncRNAs) are cellular transcripts that have more than 200 nucleotides in length and do not code for proteins. Due to their low expression levels, lncRNAs were previously considered as mere transcriptional noise. However, current evidence indicates that they regulate a myriad of biological processes such as cell proliferation, invasion, and apoptosis. Hence, their expression patterns are crucial indicators of the physiological or pathological states of cells, tissues, and organs. The utilization of lncRNAs as b...
Source: Biology of Reproduction - December 22, 2023 Category: Reproduction Medicine Authors: Enoch Appiah Adu-Gyamfi Elisha Ann Cheeran Joudi Salamah Divine Blessing Enabulele Ayesha Tahir Bum-Kyu Lee Source Type: research
BKCa channels are involved in spontaneous and LPS-stimulated uterine contraction in late gestation mice
Biol Reprod. 2023 Dec 22:ioad174. doi: 10.1093/biolre/ioad174. Online ahead of print.ABSTRACTThe large-conductance, voltage-gated, calcium (Ca2+)-activated potassium channel (BKCa) is one of the most abundant potassium channels in the myometrium. Previous work conducted by our group has identified a link between inflammation, BKCa channels and excitability of myometrial smooth muscle cells. Here we investigate the role of BKCa channels in spontaneous and lipopolysaccharide (LPS)-stimulated uterine contraction to gain a better understanding of the relationship between the BKCa channel and uterine contraction in basal and in...
Source: Biology of Reproduction - December 22, 2023 Category: Reproduction Medicine Authors: Junjie Bao Xiaofeng Ma Lindsey N Kent Monali Wakle-Prabagaran Ronald McCarthy Sarah K England Source Type: research
The role of the aryl hydrocarbon receptor in mediating the effects of mono(2-ethylhexyl) phthalate in mouse ovarian antral follicles
Biol Reprod. 2023 Dec 22:ioad178. doi: 10.1093/biolre/ioad178. Online ahead of print.ABSTRACTDi(2-ethylhexyl) phthalate (DEHP) is a pervasive environmental toxicant used in the manufacturing of numerous consumer products, medical supplies, and building materials. DEHP is metabolized to mono(2-ethylhexyl) phthalate (MEHP). MEHP is an endocrine disruptor that adversely affects folliculogenesis and steroidogenesis in the ovary, but its mechanism of action is not fully understood. Thus, we tested the hypothesis that the aryl hydrocarbon receptor (AHR) plays a functional role in MEHP-mediated disruption of folliculogenesis and ...
Source: Biology of Reproduction - December 22, 2023 Category: Reproduction Medicine Authors: Alison M Neff Zane Inman Vasiliki E Mourikes Rams és Santacruz-Márquez Andressa Gonsioroski Mary J Laws Jodi A Flaws Source Type: research
Metabolic characteristics of granulosa cell tumor: role of PPAR γ signaling
Biol Reprod. 2023 Dec 20:ioad173. doi: 10.1093/biolre/ioad173. Online ahead of print.ABSTRACTThe relative rarity of ovarian granulosa cell tumor (GCT) cases and preclinical models for GCT has posed a challenge for understanding GCT and developing therapeutics. Metabolic reprogramming is one of the key disruptions related to cancer progression. GCT exhibits significant lipid accumulation and overexpression of peroxisome proliferator-activated receptor gamma (PPARγ), a regulator of lipid metabolism. However, their roles remain unclear. Previously, we reported spontaneous GCT development in female mice with a constitutively ...
Source: Biology of Reproduction - December 20, 2023 Category: Reproduction Medicine Authors: Seok-Yeong Yu Yi Luan Pauline C Xu Yaqi Zhang Rosemary Dong Amirhossein Abazarikia So-Youn Kim Source Type: research
Metabolic characteristics of granulosa cell tumor: role of PPAR γ signaling
Biol Reprod. 2023 Dec 20:ioad173. doi: 10.1093/biolre/ioad173. Online ahead of print.ABSTRACTThe relative rarity of ovarian granulosa cell tumor (GCT) cases and preclinical models for GCT has posed a challenge for understanding GCT and developing therapeutics. Metabolic reprogramming is one of the key disruptions related to cancer progression. GCT exhibits significant lipid accumulation and overexpression of peroxisome proliferator-activated receptor gamma (PPARγ), a regulator of lipid metabolism. However, their roles remain unclear. Previously, we reported spontaneous GCT development in female mice with a constitutively ...
Source: Biology of Reproduction - December 20, 2023 Category: Reproduction Medicine Authors: Seok-Yeong Yu Yi Luan Pauline C Xu Yaqi Zhang Rosemary Dong Amirhossein Abazarikia So-Youn Kim Source Type: research
Metabolic characteristics of granulosa cell tumor: role of PPAR γ signaling
Biol Reprod. 2023 Dec 20:ioad173. doi: 10.1093/biolre/ioad173. Online ahead of print.ABSTRACTThe relative rarity of ovarian granulosa cell tumor (GCT) cases and preclinical models for GCT has posed a challenge for understanding GCT and developing therapeutics. Metabolic reprogramming is one of the key disruptions related to cancer progression. GCT exhibits significant lipid accumulation and overexpression of peroxisome proliferator-activated receptor gamma (PPARγ), a regulator of lipid metabolism. However, their roles remain unclear. Previously, we reported spontaneous GCT development in female mice with a constitutively ...
Source: Biology of Reproduction - December 20, 2023 Category: Reproduction Medicine Authors: Seok-Yeong Yu Yi Luan Pauline C Xu Yaqi Zhang Rosemary Dong Amirhossein Abazarikia So-Youn Kim Source Type: research
