Pathological shifts in tryptophan metabolism in human term placenta exposed to LPS or poly I:C
This study evaluates the effect of bacterial (LPS) and viral (poly I:C) placental infection on TRP metabolism using an ex vivo model. Human placenta explants were exposed to LPS or Poly I:C, and the release of TRP metabolites was analyzed together with the expression of related genes and proteins and the functional activity of key enzymes in TRP metabolism. The rate-limiting enzyme in the serotonin pathway, tryptophan hydroxylase, showed reduced expression and functional activity in explants exposed to LPS or Poly I:C. Conversely, the rate-limiting enzyme in the kynurenine (KYN) pathway, indoleamine dioxygenase, exhibited ...
Source: Biology of Reproduction - December 25, 2023 Category: Reproduction Medicine Authors: Cilia Abad Rona Karahoda Anna Orbisova Petr Kastner Heblik Daniel Radim Kucera Ramon Portillo Frantisek Staud Source Type: research
Vitamin D3 promotes fish oocyte development by directly regulating gonadal steroid hormone synthesis
In conclusion, this study shows that an appropriate concentration of VD3 can promote zebrafish ovarian development and affect VTG synthesis through the vdr/cyp19a1a/er/vtg gene axis.PMID:38145497 | DOI:10.1093/biolre/ioad176 (Source: Biology of Reproduction)
Source: Biology of Reproduction - December 25, 2023 Category: Reproduction Medicine Authors: Gang Yang Ke Cheng Yanqing Huang Chunfang Wang Source Type: research
Abundance of selected genes implicated in testicular functions in Camelus Dromedarius with high and low epididymal semen quality
Biol Reprod. 2023 Dec 25:ioad177. doi: 10.1093/biolre/ioad177. Online ahead of print.ABSTRACTStudying testicular genes´ expression may give key insights into precise regulation of its functions that influence epididymal sperm quality. The current study aimed to investigate the abundance of candidate genes involved in the regulation of testicular functions specially those regulate sperm function (PLA2G4D, SPP1 and CLUAP1), testicular steroidogenic function (ESR1 and AR), materials transport (AQP12B and LCN15) and defense mechanisms (DEFB110, GPX5, SOCS3 and IL6). Therefore, blood samples and testes with epididymis were col...
Source: Biology of Reproduction - December 25, 2023 Category: Reproduction Medicine Authors: Dina E M Rashad Sally Ibrahim Mohamed M M El-Sokary Karima Gh M Mahmoud Mahmoud E A Abou El-Roos Gamal A M Sosa Mohamed M M Kandiel Source Type: research
AKAP3 mediated type I PKA Signaling is required for mouse sperm Hyperactivation and fertility
Biol Reprod. 2023 Dec 25:ioad180. doi: 10.1093/biolre/ioad180. Online ahead of print.ABSTRACTProtein kinase A (PKA) signaling pathway which mediated protein phosphorylation is important for sperm motility and male fertility. This process relies on A-kinase anchoring proteins (AKAPs) that organize PKA and its signalosomes within specific subcellular compartments. Previously, it was found that the absence of AKAP3 leads to multiple morphological abnormalities in mouse sperm. But how AKAP3 regulates sperm motility is yet to be elucidated. AKAP3 has two amphipathic domains, Dual and RI in its N-terminus. These domains are resp...
Source: Biology of Reproduction - December 25, 2023 Category: Reproduction Medicine Authors: Zhongkun Liang Chaowei Dai Fenfen He Yu Wang Yihua Huang Heying Li Yongming Wu Yafang Hu Kaibiao Xu Source Type: research
Pathological shifts in tryptophan metabolism in human term placenta exposed to LPS or poly I:C
This study evaluates the effect of bacterial (LPS) and viral (poly I:C) placental infection on TRP metabolism using an ex vivo model. Human placenta explants were exposed to LPS or Poly I:C, and the release of TRP metabolites was analyzed together with the expression of related genes and proteins and the functional activity of key enzymes in TRP metabolism. The rate-limiting enzyme in the serotonin pathway, tryptophan hydroxylase, showed reduced expression and functional activity in explants exposed to LPS or Poly I:C. Conversely, the rate-limiting enzyme in the kynurenine (KYN) pathway, indoleamine dioxygenase, exhibited ...
Source: Biology of Reproduction - December 25, 2023 Category: Reproduction Medicine Authors: Cilia Abad Rona Karahoda Anna Orbisova Petr Kastner Heblik Daniel Radim Kucera Ramon Portillo Frantisek Staud Source Type: research
Vitamin D3 promotes fish oocyte development by directly regulating gonadal steroid hormone synthesis
In conclusion, this study shows that an appropriate concentration of VD3 can promote zebrafish ovarian development and affect VTG synthesis through the vdr/cyp19a1a/er/vtg gene axis.PMID:38145497 | DOI:10.1093/biolre/ioad176 (Source: Biology of Reproduction)
Source: Biology of Reproduction - December 25, 2023 Category: Reproduction Medicine Authors: Gang Yang Ke Cheng Yanqing Huang Chunfang Wang Source Type: research
Abundance of selected genes implicated in testicular functions in Camelus Dromedarius with high and low epididymal semen quality
Biol Reprod. 2023 Dec 25:ioad177. doi: 10.1093/biolre/ioad177. Online ahead of print.ABSTRACTStudying testicular genes´ expression may give key insights into precise regulation of its functions that influence epididymal sperm quality. The current study aimed to investigate the abundance of candidate genes involved in the regulation of testicular functions specially those regulate sperm function (PLA2G4D, SPP1 and CLUAP1), testicular steroidogenic function (ESR1 and AR), materials transport (AQP12B and LCN15) and defense mechanisms (DEFB110, GPX5, SOCS3 and IL6). Therefore, blood samples and testes with epididymis were col...
Source: Biology of Reproduction - December 25, 2023 Category: Reproduction Medicine Authors: Dina E M Rashad Sally Ibrahim Mohamed M M El-Sokary Karima Gh M Mahmoud Mahmoud E A Abou El-Roos Gamal A M Sosa Mohamed M M Kandiel Source Type: research
AKAP3 mediated type I PKA Signaling is required for mouse sperm Hyperactivation and fertility
Biol Reprod. 2023 Dec 25:ioad180. doi: 10.1093/biolre/ioad180. Online ahead of print.ABSTRACTProtein kinase A (PKA) signaling pathway which mediated protein phosphorylation is important for sperm motility and male fertility. This process relies on A-kinase anchoring proteins (AKAPs) that organize PKA and its signalosomes within specific subcellular compartments. Previously, it was found that the absence of AKAP3 leads to multiple morphological abnormalities in mouse sperm. But how AKAP3 regulates sperm motility is yet to be elucidated. AKAP3 has two amphipathic domains, Dual and RI in its N-terminus. These domains are resp...
Source: Biology of Reproduction - December 25, 2023 Category: Reproduction Medicine Authors: Zhongkun Liang Chaowei Dai Fenfen He Yu Wang Yihua Huang Heying Li Yongming Wu Yafang Hu Kaibiao Xu Source Type: research
Pathological shifts in tryptophan metabolism in human term placenta exposed to LPS or poly I:C
This study evaluates the effect of bacterial (LPS) and viral (poly I:C) placental infection on TRP metabolism using an ex vivo model. Human placenta explants were exposed to LPS or Poly I:C, and the release of TRP metabolites was analyzed together with the expression of related genes and proteins and the functional activity of key enzymes in TRP metabolism. The rate-limiting enzyme in the serotonin pathway, tryptophan hydroxylase, showed reduced expression and functional activity in explants exposed to LPS or Poly I:C. Conversely, the rate-limiting enzyme in the kynurenine (KYN) pathway, indoleamine dioxygenase, exhibited ...
Source: Biology of Reproduction - December 25, 2023 Category: Reproduction Medicine Authors: Cilia Abad Rona Karahoda Anna Orbisova Petr Kastner Heblik Daniel Radim Kucera Ramon Portillo Frantisek Staud Source Type: research
Vitamin D3 promotes fish oocyte development by directly regulating gonadal steroid hormone synthesis
In conclusion, this study shows that an appropriate concentration of VD3 can promote zebrafish ovarian development and affect VTG synthesis through the vdr/cyp19a1a/er/vtg gene axis.PMID:38145497 | DOI:10.1093/biolre/ioad176 (Source: Biology of Reproduction)
Source: Biology of Reproduction - December 25, 2023 Category: Reproduction Medicine Authors: Gang Yang Ke Cheng Yanqing Huang Chunfang Wang Source Type: research
Abundance of selected genes implicated in testicular functions in Camelus Dromedarius with high and low epididymal semen quality
Biol Reprod. 2023 Dec 25:ioad177. doi: 10.1093/biolre/ioad177. Online ahead of print.ABSTRACTStudying testicular genes´ expression may give key insights into precise regulation of its functions that influence epididymal sperm quality. The current study aimed to investigate the abundance of candidate genes involved in the regulation of testicular functions specially those regulate sperm function (PLA2G4D, SPP1 and CLUAP1), testicular steroidogenic function (ESR1 and AR), materials transport (AQP12B and LCN15) and defense mechanisms (DEFB110, GPX5, SOCS3 and IL6). Therefore, blood samples and testes with epididymis were col...
Source: Biology of Reproduction - December 25, 2023 Category: Reproduction Medicine Authors: Dina E M Rashad Sally Ibrahim Mohamed M M El-Sokary Karima Gh M Mahmoud Mahmoud E A Abou El-Roos Gamal A M Sosa Mohamed M M Kandiel Source Type: research
AKAP3 mediated type I PKA Signaling is required for mouse sperm Hyperactivation and fertility
Biol Reprod. 2023 Dec 25:ioad180. doi: 10.1093/biolre/ioad180. Online ahead of print.ABSTRACTProtein kinase A (PKA) signaling pathway which mediated protein phosphorylation is important for sperm motility and male fertility. This process relies on A-kinase anchoring proteins (AKAPs) that organize PKA and its signalosomes within specific subcellular compartments. Previously, it was found that the absence of AKAP3 leads to multiple morphological abnormalities in mouse sperm. But how AKAP3 regulates sperm motility is yet to be elucidated. AKAP3 has two amphipathic domains, Dual and RI in its N-terminus. These domains are resp...
Source: Biology of Reproduction - December 25, 2023 Category: Reproduction Medicine Authors: Zhongkun Liang Chaowei Dai Fenfen He Yu Wang Yihua Huang Heying Li Yongming Wu Yafang Hu Kaibiao Xu Source Type: research
Pathological shifts in tryptophan metabolism in human term placenta exposed to LPS or poly I:C
This study evaluates the effect of bacterial (LPS) and viral (poly I:C) placental infection on TRP metabolism using an ex vivo model. Human placenta explants were exposed to LPS or Poly I:C, and the release of TRP metabolites was analyzed together with the expression of related genes and proteins and the functional activity of key enzymes in TRP metabolism. The rate-limiting enzyme in the serotonin pathway, tryptophan hydroxylase, showed reduced expression and functional activity in explants exposed to LPS or Poly I:C. Conversely, the rate-limiting enzyme in the kynurenine (KYN) pathway, indoleamine dioxygenase, exhibited ...
Source: Biology of Reproduction - December 25, 2023 Category: Reproduction Medicine Authors: Cilia Abad Rona Karahoda Anna Orbisova Petr Kastner Heblik Daniel Radim Kucera Ramon Portillo Frantisek Staud Source Type: research
Vitamin D3 promotes fish oocyte development by directly regulating gonadal steroid hormone synthesis
In conclusion, this study shows that an appropriate concentration of VD3 can promote zebrafish ovarian development and affect VTG synthesis through the vdr/cyp19a1a/er/vtg gene axis.PMID:38145497 | DOI:10.1093/biolre/ioad176 (Source: Biology of Reproduction)
Source: Biology of Reproduction - December 25, 2023 Category: Reproduction Medicine Authors: Gang Yang Ke Cheng Yanqing Huang Chunfang Wang Source Type: research
Abundance of selected genes implicated in testicular functions in Camelus Dromedarius with high and low epididymal semen quality
Biol Reprod. 2023 Dec 25:ioad177. doi: 10.1093/biolre/ioad177. Online ahead of print.ABSTRACTStudying testicular genes´ expression may give key insights into precise regulation of its functions that influence epididymal sperm quality. The current study aimed to investigate the abundance of candidate genes involved in the regulation of testicular functions specially those regulate sperm function (PLA2G4D, SPP1 and CLUAP1), testicular steroidogenic function (ESR1 and AR), materials transport (AQP12B and LCN15) and defense mechanisms (DEFB110, GPX5, SOCS3 and IL6). Therefore, blood samples and testes with epididymis were col...
Source: Biology of Reproduction - December 25, 2023 Category: Reproduction Medicine Authors: Dina E M Rashad Sally Ibrahim Mohamed M M El-Sokary Karima Gh M Mahmoud Mahmoud E A Abou El-Roos Gamal A M Sosa Mohamed M M Kandiel Source Type: research
