Prognostic utility of neutrophil-to-lymphocyte ratio in patients with metastatic colorectal cancer treated using different modalities.
Authors: Nogueira-Costa G, Fernandes I, Gameiro R, Gramaça J, Xavier AT, Pina I Abstract Introduction: Inflammation is a critical component in carcinogenesis. The neutrophil-to-lymphocyte ratio (nlr) has been retrospectively studied as a biomarker of prognosis in metastatic colorectal cancer (mcrc). Compared with a low nlr, a high nlr is associated with worse prognosis. In the present study, we compared real-world survival for patients with mcrc based on their nlr group, and we assessed the utility of the nlr in determining first-line chemotherapy and metastasectomy benefit. Methods: In this retrospectiv...
Source: Current Oncology - November 13, 2020 Category: Cancer & Oncology Tags: Curr Oncol Source Type: research

Diagnostic patterns of non-small-cell lung cancer at Princess Margaret Cancer Centre.
Authors: Nadjafi M, Sung MR, Santos GDC, Le LW, Hwang DM, Tsao MS, Leighl NB Abstract Background: Accurate classification of lung cancer subtypes has become critical in tailoring lung cancer treatment. Our study aimed to evaluate changes in diagnostic testing and pathologic subtyping of advanced non-small-cell lung cancer (nsclc) over time at a major cancer centre. Methods: In a review of patients diagnosed with advanced nsclc at Princess Margaret Cancer Centre between 2007-2009 and 2013-2015, diagnostic method, sample type and site, pathologic subtype, and use of immunohistochemistry (ihc) staining and molecul...
Source: Current Oncology - November 13, 2020 Category: Cancer & Oncology Tags: Curr Oncol Source Type: research

Nodal staging affects adjuvant treatment choices in elderly patients with clinically node-negative, estrogen receptor-positive breast cancer.
Authors: Laws A, Cheifetz R, Warburton R, McGahan CE, Pao JS, Kuusk U, Dingee C, Quan ML, McKevitt E Abstract Background: In response to Choosing Wisely recommendations that sentinel lymph node biopsy (slnb) should not be routinely performed in elderly patients with node-negative (cN0), estrogen receptor-positive (er+) breast cancer, we sought to evaluate how nodal staging affects adjuvant treatment in this population. Methods: From a prospective database, we identified patients 70 or more years of age with cN0 breast cancer treated with surgery for er+ her2-negative invasive disease during 2012-2016. We determ...
Source: Current Oncology - November 13, 2020 Category: Cancer & Oncology Tags: Curr Oncol Source Type: research

A clinical investigation of the association between perioperative oral management and prognostic nutritional index in patients with digestive and urinary cancers.
Authors: Otagiri H, Yamadav S, Hashidume M, Sakurai A, Morioka M, Kondo E, Sakai H, Kurita H Abstract Background: The prognostic nutritional index (pni) is a simple metric calculated using serum albumin and the peripheral lymphocyte count. It was reported that a low pni score is significantly associated with major postoperative complications and poor prognosis. The purpose of the present study was to investigate the effects of perioperative oral management (pom) on the perioperative pni profiles of patients with digestive system or urinary cancers. Study Design: The medical records of 181 patients with cancer w...
Source: Current Oncology - November 13, 2020 Category: Cancer & Oncology Tags: Curr Oncol Source Type: research

Oncologists and medical assistance in dying: where do we stand? Results of a national survey of Canadian oncologists.
Conclusions: In this first national survey of Canadian oncologists about maid, we found that most respondents encounter patient requests for maid, are confident in their knowledge about eligibility, and are willing to act as assessors of eligibility. Many oncologists believe that, under some circumstances, it is appropriate to present maid as a therapeutic option at the end of life. That finding warrants further deliberation by national or regional bodies for the development of consensus guidelines to ensure equitable access to maid for patients who wish to pursue it. PMID: 33173378 [PubMed - in process] (Source: Current Oncology)
Source: Current Oncology - November 13, 2020 Category: Cancer & Oncology Tags: Curr Oncol Source Type: research

Canadian perspective on managing multiple myeloma during the COVID-19 pandemic: lessons learned and future considerations.
Authors: Foley R, Kaedbey R, Song K, Venner CP, White D, Doucette S, Christofides A, Reece DE Abstract The coronavirus disease 2019 (covid-19) pandemic caused by the novel severe acute respiratory syndrome coronavirus 2 has necessitated changes to the way patients with chronic diseases are managed. Given that patients with multiple myeloma are at increased risk of covid-19 infection and related complications, national bodies and experts around the globe have made recommendations for risk mitigation strategies for those vulnerable patients. Understandably, because of the novelty of the virus, many of the proposed ri...
Source: Current Oncology - November 13, 2020 Category: Cancer & Oncology Tags: Curr Oncol Source Type: research

Prevention and treatment of cancer-associated thrombosis.
Authors: Ng S, Carrier M Abstract Cancer is a hypercoagulable state with an associated increased risk of venous thromboembolism (vte) that is further amplified in individuals who undergo chemotherapy. Compared with patients having cancer alone or vte alone, patients who develop cancer-associated vte have a significantly poorer prognosis. The risks of recurrent vte despite appropriate anticoagulation therapy and of bleeding are also higher in patients with cancer than in those without. For those reasons, the prevention and appropriate management of cancer-associated thrombosis is of paramount importance. Although lo...
Source: Current Oncology - November 13, 2020 Category: Cancer & Oncology Tags: Curr Oncol Source Type: research

The implications of COVID-19 in radiation oncology in the United States.
Authors: Odei B, Quick A PMID: 33173381 [PubMed - in process] (Source: Current Oncology)
Source: Current Oncology - November 13, 2020 Category: Cancer & Oncology Tags: Curr Oncol Source Type: research

Multicentric chondrosarcoma involving the appendicular skeleton: a case report and literature review.
This article therefore provides a rare case report alongside a review of additional cases in the medical literature. PMID: 33173382 [PubMed - in process] (Source: Current Oncology)
Source: Current Oncology - November 13, 2020 Category: Cancer & Oncology Tags: Curr Oncol Source Type: research

Osteopontin level and promoter polymorphism in patients with metastatic breast cancer.
Conclusions: The current prospective work helps to highlight opn as a valid prognostic biomarker for patients with metastatic bca and reveals that high pretreatment serum opn and opn gene mutation are both strongly linked with poor response and survival. Concordance between elisa and pcr results indicates that either method can be used for the evaluation of opn. Increased opn gene mutation in triple-negative bca could assist in tailoring the treatment response in this very aggressive tumour subtype and could be considered a targetable molecule in future studies. PMID: 33173383 [PubMed - in process] (Source: Current Oncology)
Source: Current Oncology - November 13, 2020 Category: Cancer & Oncology Tags: Curr Oncol Source Type: research

Quality of life in a real-world study of patients with metastatic colorectal cancer treated with trifluridine/tipiracil.
Conclusions: This study suggests that ftd/tpi is a well-tolerated option for the treatment of patients with refractory mcrc, showcasing the value of capturing real-world qol data in routine clinical practice. PMID: 33173384 [PubMed - in process] (Source: Current Oncology)
Source: Current Oncology - November 13, 2020 Category: Cancer & Oncology Tags: Curr Oncol Source Type: research

Understanding clinical practice and survival outcomes in patients with unresectable stage III non-small-cell lung cancer in a single centre in Quebec.
Authors: Agulnik J, Kasymjanova G, Pepe C, Hurry M, Walton RN, Sakr L, Cohen V, Lecavalier M, Small D Abstract Methods: A retrospective cohort study considered patients 18 or more years of age diagnosed between January 2007 and May 2018 with unresectable stage iii non-small-cell lung cancer (nsclc) who received combined chemoradiation (crt). Survival was analyzed using the Kaplan-Meier method to determine median overall (os) and progression-free survival (pfs) and the associated 95% confidence intervals (cis). Cox regression analysis was performed to identify factors prognostic for survival, including age, sex, smo...
Source: Current Oncology - November 13, 2020 Category: Cancer & Oncology Tags: Curr Oncol Source Type: research

Delay in diagnosis of patients with head-and-neck cancer in Canada: impact of patient and provider delay.
Conclusions: At our tertiary care cancer centre, a patient's clinical pathway to being seen at the mdt clinic shows significant delays, particularly in the time from the first hcp visit to mdt referral. Possible methods to mitigate delay include education about hnc for patients and providers alike, and a more streamlined referral system. PMID: 33173386 [PubMed - in process] (Source: Current Oncology)
Source: Current Oncology - November 13, 2020 Category: Cancer & Oncology Tags: Curr Oncol Source Type: research

Cigarette-smoking characteristics and interest in cessation in patients with head-and-neck cancer.
Conclusions: Patients with head-and-neck cancer reported high nicotine dependence and high interest in cessation opportunities near the time of treatment for cancer. Those results might provide support for provision of smoking cessation opportunities. PMID: 33173387 [PubMed - in process] (Source: Current Oncology)
Source: Current Oncology - November 13, 2020 Category: Cancer & Oncology Tags: Curr Oncol Source Type: research

The risk of diarrhea and colitis in patients with lung cancer treated with immune checkpoint inhibitors: a systematic review and meta-analysis.
Conclusions: Diarrhea is a relatively frequently encountered gi toxicity when ici therapy is used in lung cancer treatment. Colitis is less frequently encountered, although when it does occur, it often results in therapy discontinuation. PMID: 33173388 [PubMed - in process] (Source: Current Oncology)
Source: Current Oncology - November 13, 2020 Category: Cancer & Oncology Tags: Curr Oncol Source Type: research

Reimbursement recommendations for cancer drugs supported by phase II evidence in Canada.
Authors: Li YYR, Mai H, Trudeau ME, Mittmann N, Chiasson K, Chan KKW, Cheung MC Abstract Background: Phase ii data are increasingly being used as primary evidence for public reimbursement for oncologic drugs. We compared the frequency of reimbursement recommendations for phase ii and phase iii submissions and assessed for variables associated with a positive or conditional recommendation. Methods: We identified submissions made to the pan-Canadian Oncology Drug Review's Expert Review Committee (perc), of the Canadian Agency for Drugs and Technologies in Health, July 2011 to July 2019, that were supported only b...
Source: Current Oncology - November 13, 2020 Category: Cancer & Oncology Tags: Curr Oncol Source Type: research

Strategies for the delay of surgery in the management of resectable hepatobiliary malignancies during the COVID-19 pandemic.
Conclusions: There are a variety of delaying strategies to consider if availability of operating rooms decreases. This review summarizes available data to provide guidance about possible delaying strategies depending on patient, resource, institution, and systems factors. Multidisciplinary team discussions should be leveraged to consider patient- and tumour-specific information for each individual case. PMID: 33173390 [PubMed - in process] (Source: Current Oncology)
Source: Current Oncology - November 13, 2020 Category: Cancer & Oncology Tags: Curr Oncol Source Type: research

Musculoskeletal oncology: patient triage and management during the COVID-19 pandemic.
Authors: Olshinka N, Mottard S Abstract Sarcoma treatment during the covid-19 pandemic is a new challenge. This patient population is often immunocompromised and potentially more susceptible to viral complications. Government guidelines highlight the need to minimize patient exposure to unnecessary hospital visits. However, those guidelines lack practical recommendations on ways to manage triage and diagnosis expressly for new cancer patients. Furthermore, there are no reports on the efficiency of the guidelines. One of the main issues in treating musculoskeletal tumours is the complexity and variability of present...
Source: Current Oncology - November 13, 2020 Category: Cancer & Oncology Tags: Curr Oncol Source Type: research

A pan-Canadian prospective study of young women with breast cancer: the rationale and protocol design for the RUBY study.
We present the rationale, design, and initial recruitment of Reducing the Burden of Breast Cancer in Young Women (ruby), a unique national prospective cohort study designed to examine the diagnosis, treatment, quality of life, and outcomes from the time of diagnosis for young women with bca. Methods: Over a 4-year period at 33 sites across Canada, the ruby study will use a local and virtual recruitment model to enrol 1200 women with bca who are 40 years of age or younger at the time of diagnosis, before initiation of any treatment. At a minimum, comprehensive patient, tumour, and treatment data will be collected to eva...
Source: Current Oncology - November 13, 2020 Category: Cancer & Oncology Tags: Curr Oncol Source Type: research

Improving formative assessments in Canadian medical oncology residency training.
Authors: Arora R, Mukherjee SD PMID: 33173393 [PubMed - in process] (Source: Current Oncology)
Source: Current Oncology - November 13, 2020 Category: Cancer & Oncology Tags: Curr Oncol Source Type: research

UNCOVID-a 55-word story.
Authors: Wald HS PMID: 33173394 [PubMed - in process] (Source: Current Oncology)
Source: Current Oncology - November 13, 2020 Category: Cancer & Oncology Tags: Curr Oncol Source Type: research

The importance of humour in oncology: a survey of patients undergoing radiotherapy.
Conclusions: Cancer patients undergoing radiotherapy clearly view humour as being important for coping and dealing with their disease, and oncology hcps should routinely consider incorporating the use of appropriate humour into the care that they provide. PMID: 32905157 [PubMed - as supplied by publisher] (Source: Current Oncology)
Source: Current Oncology - September 10, 2020 Category: Cancer & Oncology Tags: Curr Oncol Source Type: research

Does dissemination of guidelines alone increase the use of palliative single-fraction radiotherapy? Initial report of a longitudinal change management campaign at a provincial cancer program.
Conclusions: Dissemination of cwc recommendations alone did not increase sfrt use by radiation oncologists in 2016. A more comprehensive knowledge translation effort is therefore warranted and is now underway to encourage increased uptake of sfrt in Manitoba. PMID: 32905177 [PubMed - as supplied by publisher] (Source: Current Oncology)
Source: Current Oncology - September 10, 2020 Category: Cancer & Oncology Tags: Curr Oncol Source Type: research

Canadian cohort expanded-access program of nivolumab plus ipilimumab in advanced melanoma.
Conclusions: In this Canadian population, nivolumab plus ipilimumab demonstrated a safety profile and survival outcomes consistent with phase ii and iii clinical trial data. PMID: 32905202 [PubMed - as supplied by publisher] (Source: Current Oncology)
Source: Current Oncology - September 10, 2020 Category: Cancer & Oncology Tags: Curr Oncol Source Type: research

CAMO 2020 Annual Meeting Abstracts: Canadian Association of Medical Oncologists.
Authors: PMID: 32905203 [PubMed] (Source: Current Oncology)
Source: Current Oncology - September 10, 2020 Category: Cancer & Oncology Tags: Curr Oncol Source Type: research

The case for breast-conservation treatment rates to be a quality metric.
Authors: Tan MP, Silva E PMID: 32905204 [PubMed - as supplied by publisher] (Source: Current Oncology)
Source: Current Oncology - September 10, 2020 Category: Cancer & Oncology Tags: Curr Oncol Source Type: research

Severe cytomegalovirus gastritis after pembrolizumab in a patient with melanoma.
Authors: Kim H, Ha SY, Kim J, Kang M, Lee J Abstract Immunotherapy has emerged as a standard of cancer treatment, with an increasing number of indications. Recently, opportunistic infections have been reported in several cases in which immunotherapy has led to an increased susceptibility to infection. The present case is the first report of cytomegalovirus (cmv) gastritis occurring in a patient with melanoma during immunotherapy without immune-related adverse events (iraes) and without the use of immunosuppressant agents. A 43-year-old woman presented with stage iii malignant melanoma. She underwent wide excision o...
Source: Current Oncology - September 10, 2020 Category: Cancer & Oncology Tags: Curr Oncol Source Type: research

Chest wall toxicity after stereotactic radiation in early lung cancer: a systematic review.
Conclusions: In patients with stage i nsclc, rates of cwp and rf after sbrt are low; however, tumour location, accurate toxicity reporting, and dose-fractionation schemes might alter those rates. Prospective correlation with dosimetry and quality of life assessment will further improve the understanding of cwp and rf after sbrt. PMID: 32905234 [PubMed - as supplied by publisher] (Source: Current Oncology)
Source: Current Oncology - September 10, 2020 Category: Cancer & Oncology Tags: Curr Oncol Source Type: research

Breast cancer diagnosis and treatment wait times in specialized diagnostic units compared with usual care: a population-based study.
Conclusions: Diagnosis of bca through a bas was associated with a shorter diagnostic interval, but a longer treatment interval. Although efficiencies in the diagnostic interval might help to reduce distress experienced by patients, the longer treatment intervals for patients who are bas-diagnosed remain a cause for concern. PMID: 32905256 [PubMed - as supplied by publisher] (Source: Current Oncology)
Source: Current Oncology - September 10, 2020 Category: Cancer & Oncology Tags: Curr Oncol Source Type: research

A cost-utility analysis of atezolizumab in the second-line treatment of patients with metastatic bladder cancer.
Conclusions: Despite lessened aes and preserved qol, atezolizumab is not considered cost-effective for the second-line treatment of mbc. PMID: 32905260 [PubMed - as supplied by publisher] (Source: Current Oncology)
Source: Current Oncology - September 10, 2020 Category: Cancer & Oncology Tags: Curr Oncol Source Type: research

Retrospective cohort study of unresectable stage III non-small-cell lung cancer in Canada.
Conclusions: Guideline-recommended ccrt is undertaken in only a small proportion of patients with unresectable nsclc in Ontario. The reasons for low uptake of that recommendation are only partly understood. PMID: 32905267 [PubMed - as supplied by publisher] (Source: Current Oncology)
Source: Current Oncology - September 10, 2020 Category: Cancer & Oncology Tags: Curr Oncol Source Type: research

Risk factors for venous thromboembolism in endometrial cancer.
Authors: Pin S, Mateshaytis J, Ghosh S, Batuyong E, Easaw JC Abstract Background: Venous thromboembolism (vte) in malignancy is associated with poor outcomes. We conducted a retrospective review of vte in patients with endometrial cancer to characterize the vte incidence, identify factors that contribute to vte risk, and compare survival outcomes in patients with and without vte. Methods: A retrospective chart review identified 422 eligible patients who underwent surgery for endometrial cancer (1 January 2014 to 31 July 2016). The primary outcome was vte. Binary logistic regression identified risk factors for v...
Source: Current Oncology - September 10, 2020 Category: Cancer & Oncology Tags: Curr Oncol Source Type: research

Practical update for the use of bone-targeted agents in patients with bone metastases from metastatic breast cancer or castration-resistant prostate cancer.
Authors: Southcott D, Awan A, Ghate K, Clemons M, Fernandes R Abstract Bone metastases are a significant source of morbidity and mortality for patients with breast and prostate cancer. In this review, we discuss key practical themes regarding the use of bone-targeted agents (btas) such as bisphosphonates and denosumab for managing bony metastatic disease. The btas both delay the onset and reduce the incidence of skeletal-related events (sres), defined as any or all of a need for radiation therapy or surgery to bone, pathologic fracture, spinal cord compression, or hypercalcemia of malignancy. They have more modest ...
Source: Current Oncology - September 10, 2020 Category: Cancer & Oncology Tags: Curr Oncol Source Type: research

Highlights from ASCO 2020: updates on the treatment of chronic lymphocytic leukemia.
Authors: Dolan S, Christofides A, Doucette S, Shafey M Abstract Because of the global coronavirus pandemic, the 2020 annual scientific meeting of the American Society of Clinical Oncology took place virtually, 29-30 May. At the meeting, results from key studies about the treatment of chronic lymphocytic leukemia (cll) were disseminated. Studies examined the efficacy and safety of ibrutinib, acalabrutinib, zanubrutinib, and venetoclax as monotherapy or in combination with novel agents for patients with treatment-naïve and relapsed or refractory cll. Our meeting report describes the foregoing studies and present...
Source: Current Oncology - September 10, 2020 Category: Cancer & Oncology Tags: Curr Oncol Source Type: research

Real-world treatment patterns and survival in stage IV non-small-cell lung cancer in Canada.
Conclusions: Survival of patients with stage iv nsclc remains poor, with the exception of patients who are EGFRm+. Only 14.9% of patients received first-line chemotherapy; the mainstay of treatment was palliative radiotherapy. PMID: 32905294 [PubMed - as supplied by publisher] (Source: Current Oncology)
Source: Current Oncology - September 10, 2020 Category: Cancer & Oncology Tags: Curr Oncol Source Type: research

Cancer and COVID-19: how understanding grief helps the pandemic frontlines.
Authors: Kahn AM, Andrews R PMID: 32905296 [PubMed - as supplied by publisher] (Source: Current Oncology)
Source: Current Oncology - September 10, 2020 Category: Cancer & Oncology Tags: Curr Oncol Source Type: research

Association between known risk factors and colorectal cancer risk in Indigenous people participating in the Ontario Familial Colon Cancer Registry.
Conclusions: Findings were consistent with previous literature describing Indigenous populations. A small sample size and poor Indigenous identification questions make it challenging to comprehensively understand cancer risk factors and burden in Indigenous populations. PMID: 32905327 [PubMed - as supplied by publisher] (Source: Current Oncology)
Source: Current Oncology - September 10, 2020 Category: Cancer & Oncology Tags: Curr Oncol Source Type: research

Age-dependent increased odds of cardiovascular risk factors in cancer survivors: Canadian Longitudinal Study on Aging cohort.
Conclusions: The odds of several easy-to-assess cv disease risk factors are higher among middle-aged, but not older, cancer survivors relative to the general Canadian population. Initial assessment of cv risk for middle-aged adults in the survivorship setting could be quickly and inexpensively performed using self-reported and easily measured metrics. PMID: 32905332 [PubMed - as supplied by publisher] (Source: Current Oncology)
Source: Current Oncology - September 10, 2020 Category: Cancer & Oncology Tags: Curr Oncol Source Type: research

Multidisciplinary management of locally advanced and metastatic cutaneous squamous cell carcinoma.
Authors: Claveau J, Archambault J, Ernst DS, Giacomantonio C, Limacher JJ, Murray C, Parent F, Zloty D Abstract Non-melanoma skin cancers are the most prevalent form of cancer, with cutaneous squamous cell carcinoma (cscc) being the 2nd most common type. Patients presenting with high-risk lesions associated with locally advanced or metastatic cscc face high rates of recurrence and mortality. Accurate staging and risk stratification for patients can be challenging because no system is universally accepted, and no Canadian guidelines currently exist. Patients with advanced cscc are often deemed ineligible for either ...
Source: Current Oncology - September 10, 2020 Category: Cancer & Oncology Tags: Curr Oncol Source Type: research

Sequence of therapy and survival in patients with advanced pancreatic neuroendocrine tumours.
Authors: Tsang ES, Loree JM, Speers C, Kennecke HF Abstract Background: Pancreatic neuroendocrine tumours (pnets) often present as advanced disease. The optimal sequence of therapy is unknown. Methods: Sequential patients with advanced pnets referred to BC Cancer between 2000 and 2013 who received 1 or more treatment modalities were reviewed, and treatment patterns, progression-free survival (pfs), and overall survival (os) were characterized. Systemic treatments included chemotherapy, small-molecule therapy, and peptide receptor radionuclide therapy. Results: In 66 cases of advanced pnets, median patient a...
Source: Current Oncology - September 10, 2020 Category: Cancer & Oncology Tags: Curr Oncol Source Type: research

Cutaneous paraneoplastic syndrome associated with anal squamous cell carcinoma: a rare presentation of an uncommon cancer.
Authors: Saeed A, Hameem ZU, Modi D, Park R, Saeed A Abstract Paraneoplastic syndromes associated with anal squamous cell carcinoma (scc) are rare. Erythema gyratum repens (egr) is a cutaneous paraneoplastic syndrome with distinctive characteristics. Here, we report the rare case of a 73-year-old woman with a chronic erythematous rash for 11 months associated with intense pruritus. She was treated with prednisone and antihistamines by dermatologists, but did not respond. The patient was subsequently seen in our clinic for unintentional weight loss and anorexia with intermittent nausea and vomiting. During further e...
Source: Current Oncology - September 10, 2020 Category: Cancer & Oncology Tags: Curr Oncol Source Type: research

Nivolumab and ipilimumab immunotherapy for hemodialysis patients with advanced renal cell carcinoma.
We present a case of advanced clear-cell renal cell carcinoma in a patient on hemodialysis who received combined immune checkpoint blockade with nivolumab and ipilimumab and who showed no evident signs of immune-related adverse events. Here, we confirm the safety and efficacy of combined immune checkpoint blockade with nivolumab and ipilimumab in a patient on hemodialysis. PMID: 32905370 [PubMed - as supplied by publisher] (Source: Current Oncology)
Source: Current Oncology - September 10, 2020 Category: Cancer & Oncology Tags: Curr Oncol Source Type: research

The challenge of creating evidence-based clinical practice guidelines for the use of hyperthermic intraperitoneal chemotherapy in the management of peritoneal malignancies.
Authors: Knapp GC, Mack LA PMID: 32669920 [PubMed - in process] (Source: Current Oncology)
Source: Current Oncology - July 17, 2020 Category: Cancer & Oncology Tags: Curr Oncol Source Type: research

Willingness of women with early estrogen receptor-positive breast cancer to take adjuvant CDK4/6 inhibitors.
Conclusions: The willingness of patients with estrogen receptor-positive bca to take an adjuvant cdk4/6 inhibitor will greatly depend on the expected benefit and toxicities described to them as well as on worry about bca recurrence. PMID: 32669921 [PubMed - in process] (Source: Current Oncology)
Source: Current Oncology - July 17, 2020 Category: Cancer & Oncology Tags: Curr Oncol Source Type: research

Inflammatory markers as prognostic factors of recurrence in advanced-stage squamous cell carcinoma of the head and neck.
Conclusions: In patients with head-and-neck scc, a stronger prognostic value is associated with human papillomavirus status than with nlr and many other factors, including bmi and albumin. However, even though few of our patients had high crp, serum crp remained significant despite p16-positive status. PMID: 32669922 [PubMed - in process] (Source: Current Oncology)
Source: Current Oncology - July 17, 2020 Category: Cancer & Oncology Tags: Curr Oncol Source Type: research

Management of dyspnea in palliative care.
Authors: Crombeen AM, Lilly EJ Abstract Dyspnea is a symptom commonly experienced by cancer patients that causes significant suffering, worsens throughout a patient's disease trajectory, and can be more difficult to manage than other symptoms. Assessment of dyspnea is best accomplished by a subjective description; physiologic measures are only weakly correlated with the patient's experience. It is important to consider a wide range of possible malignant and nonmalignant causes of dyspnea in cancer patients and to correct underlying causes where possible. For patients with refractory dyspnea, opioids are a safe and ...
Source: Current Oncology - July 17, 2020 Category: Cancer & Oncology Tags: Curr Oncol Source Type: research

Indications for hyperthermic intraperitoneal chemotherapy with cytoreductive surgery: a clinical practice guideline.
Authors: Auer RC, Sivajohanathan D, Biagi J, Conner J, Kennedy E, May T Abstract Objective: The purpose of the present review was to provide evidence-based guidance about the provision of cytoreductive surgery (crs) with hyperthermic intraperitoneal chemotherapy (hipec) in the treatment of peritoneal cancers. Methods: The guideline was developed by the Program in Evidence-Based Care together with the Surgical Oncology Program at Ontario Health (Cancer Care Ontario) through a systematic review of relevant literature, patient- and caregiver-specific consultation, and internal and external reviews. Results: Re...
Source: Current Oncology - July 17, 2020 Category: Cancer & Oncology Tags: Curr Oncol Source Type: research

Tumour response 3 months after neoadjuvant single-fraction radiotherapy for low-risk breast cancer.
Conclusions: This study demonstrates a method for delivering single-fraction rt that can lead to a high level of pr in most patients. Continued accrual to this study and subsequent trials are needed to determine the feasibility, safety, and role of this novel technique in the management of early-stage bca. PMID: 32669925 [PubMed - in process] (Source: Current Oncology)
Source: Current Oncology - July 17, 2020 Category: Cancer & Oncology Tags: Curr Oncol Source Type: research

Impact of the COVID-19 outbreak on adjuvant chemotherapy for patients with stage II or III colon cancer: experiences from a multicentre clinical trial in China.
Authors: Sun L, Xu Y, Zhang T, Yang Y PMID: 32669926 [PubMed - in process] (Source: Current Oncology)
Source: Current Oncology - July 17, 2020 Category: Cancer & Oncology Tags: Curr Oncol Source Type: research

Preparing for the renaissance: treating breast cancer during the COVID-19 pandemic and planning for a safe re-emergence to routine surgical care within a universal health care system.
Authors: Berger-Richardson D, Ko G, Hong NJL PMID: 32669927 [PubMed - in process] (Source: Current Oncology)
Source: Current Oncology - July 17, 2020 Category: Cancer & Oncology Tags: Curr Oncol Source Type: research