Malignant Skin Cancer Excision in Combined Therapy with Electro-Chemotherapy and Dermal Substitute
This study shows that combined surgical selective excision with ECT and CDT is a valid technique for the extended-deep dorsal hand tumor lesions reconstruction.PMID:34063113 | PMC:PMC8161833 | DOI:10.3390/curroncol28030160 (Source: Current Oncology)
Source: Current Oncology - June 2, 2021 Category: Cancer & Oncology Authors: Barbara De Angelis Alberto Balzani Alessia Pagnotta Eleonora Tati Fabrizio Orlandi Margarida Fernandes Lopes Morais D'Autilio Valerio Cervelli Pietro Gentile Source Type: research

Successful Alectinib Treatment for Carcinoma of Unknown Primary with < em > EML4-ALK < /em > Fusion Gene: A Case Report
Curr Oncol. 2021 May 21;28(3):1938-1945. doi: 10.3390/curroncol28030180.ABSTRACTGene alteration in anaplastic lymphoma kinase (ALK) is rare, and the efficacy of ALK inhibitors in the treatment of carcinoma of unknown primary (CUP) with ALK alteration remains unclear. The patient was a 56-year-old woman who presented with cervical lymph node swelling. Computed tomography revealed paraaortic, perigastric, and cervical lymph node swelling; ascites; a liver lesion; and a left adrenal mass. A cervical lymph node biopsy was performed, and pathological diagnosis of an undifferentiated malignant tumor was conducted. Finally, the p...
Source: Current Oncology - June 2, 2021 Category: Cancer & Oncology Authors: Keiji Sugiyama Ai Izumika Akari Iwakoshi Riko Nishibori Mariko Sato Kazuhiro Shiraishi Hiroyoshi Hattori Rieko Nishimura Chiyoe Kitagawa Source Type: research

Cost Analysis of Laparoscopic Low Anterior Resection vs. Transanal Endoscopic Microsurgery for Rectal Neoplasms
This study compares the cost of TEM to laparoscopic low anterior resection (LAR). Patients who underwent laparoscopic LAR (n = 24) for rectal neoplasm between 2006 and 2014 were case-matched based on sex, age, comorbidities, lesion size and location to patients who underwent TEM at a busy secondary care urban hospital. Procedure-related costs and costs associated with readmissions for complications and related subsequent surgeries in the first 3 years were calculated. There were 42 hospital admissions for 24 LAR patients, totalling 326 hospital days. For 24 TEM patients, there were 25 hospital admissions, totalling 56 hosp...
Source: Current Oncology - June 2, 2021 Category: Cancer & Oncology Authors: Katerina Neumann Nirmal Randhawa Jason Park David J Hochman Source Type: research

Current Landscape of Targeted Therapy in Hormone Receptor-Positive and HER2-Negative Breast Cancer
Discussion: Targeted treatment options for HR + BC have evolved. The future of overcoming resistance to targeted therapy, novel compounds, and predictive markers are key to improving HR + BC outcomes.PMID:34064867 | PMC:PMC8161804 | DOI:10.3390/curroncol28030168 (Source: Current Oncology)
Source: Current Oncology - June 2, 2021 Category: Cancer & Oncology Authors: Samitha Andrahennadi Amer Sami Mita Manna Mehrnoosh Pauls Shahid Ahmed Source Type: research

Cytoreductive Nephrectomy Following Immunotherapy-Base Treatment in Metastatic Renal Cell Carcinoma: A Case Series and Review of Current Literature
Curr Oncol. 2021 May 20;28(3):1921-1926. doi: 10.3390/curroncol28030178.ABSTRACTThe role and timing of cytoreductive nephrectomy in patients with metastatic renal cell carcinoma receiving immunotherapy-based regimens is unclear. However, the ability to achieve a complete response for metastatic renal cell carcinoma likely requires a nephrectomy at some point during treatment. Here we present a case series of three patients with metastatic clear-cell renal-cell carcinoma who received front-line immunotherapy-based treatment and subsequently underwent a cytoreductive nephrectomy. All three patients had a complete response to...
Source: Current Oncology - June 2, 2021 Category: Cancer & Oncology Authors: Scott J Dawsey Steven C Campbell Moshe C Ornstein Source Type: research

Cancer Testis Antigen, NOL4, Is an Immunogenic Antigen Specifically Expressed in Small-Cell Lung Cancer
Curr Oncol. 2021 May 20;28(3):1927-1937. doi: 10.3390/curroncol28030179.ABSTRACTTo identify cancer/testis (CT) antigens and immunogenic proteins, immunoscreening of testicular and small-cell lung cancer cell line NCI-H889 cDNA libraries was performed using serum obtained from a small-cell lung cancer (SCLC) patient. We obtained 113 positive cDNA clones comprised of 74 different genes, designated KP-SCLC-1 through KP-SCLC-74. Of these genes, 59 genes were found to be related to cancers by EMBASE analysis. Three of these antigens, including KP-SCLC-29 (NOL4), KP-SCLC-59 (CCDC83), and KP-SCLC-69 (KIF20B), were CT antigens. RT...
Source: Current Oncology - June 2, 2021 Category: Cancer & Oncology Authors: Ye-Rin Kim Ki-Uk Kim Jung-Hee Lee Deok-Won Kim Jae-Heun Chung Yeong-Dae Kim Dong-Hoon Shin Min-Ki Lee Yong-Il Shin Sang-Yull Lee Source Type: research

Diagnostic Performance of PI-RADS v2, Proposed Adjusted PI-RADS v2 and Biparametric Magnetic Resonance Imaging for Prostate Cancer Detection: A Preliminary Study
CONCLUSIONS: The overall diagnostic performance of the three protocols showed minimal differences. For lesions assessed as being category 3 using the biparametric MRI protocol, PI-RADS v2, or PA PI-RADS v2, it was thought prostate cancer detection could be improved. Attention should be paid to false positive results when PI-RADS v2 or PA PI-RADS v2 are used.PMID:34065851 | PMC:PMC8161832 | DOI:10.3390/curroncol28030169 (Source: Current Oncology)
Source: Current Oncology - June 2, 2021 Category: Cancer & Oncology Authors: Guan-Hui Cai Qi-Hua Yang Wen-Bo Chen Qing-Yu Liu Yu-Rong Zeng Yu-Jing Zeng Source Type: research

Cancer Screening Interventions in Indigenous Populations: A Rapid Review
Curr Oncol. 2021 May 6;28(3):1728-1743. doi: 10.3390/curroncol28030161.ABSTRACTCancer screening is an important component of a cancer control strategy. Indigenous people in Canada have higher incidence rates for many types of cancer, including those that can be detected early or prevented through organized screening programs. Increased participation and retention in cancer screening is critical to improved population health outcomes amongst Indigenous people. This rapid review evaluates cancer screening interventions published in the last six years. Included studies demonstrated increased participation in breast, colorecta...
Source: Current Oncology - June 2, 2021 Category: Cancer & Oncology Authors: Janell Bryant Kara Patterson Marcus Vaska Bonnie Chiang Angeline Letendre Lea Bill Huiming Yang Karen Kopciuk Source Type: research

Impact of an Augmented Reality Navigation System (SIRIO) on Bone Percutaneous Procedures: A Comparative Analysis with Standard CT-Guided Technique
Curr Oncol. 2021 May 8;28(3):1751-1760. doi: 10.3390/curroncol28030163.ABSTRACT(1) Background: The purpose of this study is to evaluate the impact of an augmented reality navigation system (SIRIO) for percutaneous biopsies and ablative treatments on bone lesions, compared to a standard CT-guided technique. (2) Methods: Bioptic and ablative procedures on bone lesions were retrospectively analyzed. All procedures were divided into SIRIO and Non-SIRIO groups and in 2 cm groups. Number of CT-scans, procedural time and patient's radiation dose were reported for each group. Diagnostic accuracy was obtained for bioptic procedures...
Source: Current Oncology - June 2, 2021 Category: Cancer & Oncology Authors: Eliodoro Faiella Gennaro Castiello Caterina Bernetti Giuseppina Pacella Carlo Altomare Flavio Andresciani Bruno Beomonte Zobel Rosario Francesco Grasso Source Type: research

Activity and Safety of NAB-FOLFIRI and NAB-FOLFOX as First-Line Treatment for metastatic Pancreatic Cancer (NabucCO Study)
CONCLUSION: Nab-FOLFIRI and Nab-FOLFOX might be hopeful first-line CT options for mPC patients, with promising activity and a good safety profile.PMID:34066784 | PMC:PMC8161763 | DOI:10.3390/curroncol28030164 (Source: Current Oncology)
Source: Current Oncology - June 2, 2021 Category: Cancer & Oncology Authors: Elisa Giommoni Evaristo Maiello Vanja Vaccaro Ermanno Rondini Caterina Vivaldi Giampaolo Tortora Laura Toppo Guido Giordano Tiziana Pia Latiano Cinzia Lamperini Serena Pillozzi Luca Boni Lorenzo Antonuzzo Francesco Di Costanzo Source Type: research

Predictors of Urgent Cancer Care Clinic and Emergency Department Visits for Individuals Diagnosed with Cancer
Curr Oncol. 2021 May 8;28(3):1773-1789. doi: 10.3390/curroncol28030165.ABSTRACTIn 2013, CancerCare Manitoba (CCMB) launched an urgent cancer care clinic (UCC) to meet the needs of individuals diagnosed with cancer experiencing acute complications of cancer or its treatment. This retrospective cohort study compared the characteristics of individuals diagnosed with cancer that visited the UCC to those who visited an emergency department (ED) and determined predictors of use. Multivariable logistic mixed models were run to predict an individual's likelihood of visiting the UCC or an ED. Scaled Brier scores were calculated to ...
Source: Current Oncology - June 2, 2021 Category: Cancer & Oncology Authors: Kathleen Decker Pascal Lambert Katie Galloway Oliver Bucher Marshall Pitz Benjamin Goldenberg Harminder Singh Mark Kristjanson Tunji Fatoye Eric J Bow Source Type: research

Stereotactic Radiotherapy in the Treatment of Paraneoplastic Vasculitis in Oligometastatic Renal Cell Carcinoma
We present a case of a previously healthy male who presented with systemic vasculitis; bitemporal headaches, diplopia, polyarthritis, palpable purpura, tongue lesion, peri-orbital edema, scleritis, chondritis and constitutional symptoms. He was subsequently found to have oligometastatic RCC. Both his primary lesion and site of oligometastasis were treated with stereotactic radiotherapy (SBRT) and resulted in the resolution of his vasculitis, as well as sustained oncologic response. This is the first case to demonstrate that effective sustained treatment for PNS vasculitis due to oligometastatic RCC is possible with SBRT.PM...
Source: Current Oncology - June 2, 2021 Category: Cancer & Oncology Authors: Laura Burgess Marissa Keenan Alan Liang Zhou Kiefer Lypka Delvina Hasimja Saraqini Jeff Yao Samuel Martin Christopher Morash James Watterson Christina Canil Robert MacRae Source Type: research

Re-Irradiation for Locally Recurrent Lung Cancer: A Single Center Retrospective Analysis
Curr Oncol. 2021 May 13;28(3):1835-1846. doi: 10.3390/curroncol28030170.ABSTRACTThe treatment of locally recurrent lung cancer is a major challenge for radiation-oncologists, especially with data on high-dose reirradiation being limited to small retrospective studies. The aim of the present study is to assess overall survival (OS) for patients with locally recurrent lung cancer after high-dose thoracic reirradiation. Thirty-nine patients who were re-irradiated for lung cancer relapse between October 2013 and February 2019 were eligible for the current retrospective analysis. All patients were re-irradiated with curative in...
Source: Current Oncology - June 2, 2021 Category: Cancer & Oncology Authors: Brane Grambozov Evelyn Nussdorfer Julia Kaiser Sabine Gerum Gerd Fastner Markus Stana Christoph Gaisberger Romana Wass Michael Studnicka Felix Sedlmayer Franz Zehentmayr Source Type: research

Cost-Effectiveness Analysis of 12-Versus 4-Weekly Administration of Bone-Targeted Agents in Patients with Bone Metastases from Breast and Castration-Resistant Prostate Cancer
Curr Oncol. 2021 May 13;28(3):1847-1856. doi: 10.3390/curroncol28030171.ABSTRACTA cost-utility analysis was performed based on the Rethinking Clinical Trials (REaCT) bone-targeted agents (BTA) clinical trial that compared 12-weekly (once every 12 weeks) (n = 130) versus 4-weekly (once every 4 weeks) (n = 133) BTA dosing for metastatic breast and castration-resistant prostate (CRPC) cancer. Using a decision tree model, we calculated treatment and symptomatic skeletal event (SSE) costs as well as quality-adjusted life-years (QALYs) for each treatment option. Deterministic and probabilistic sensitivity analyses were performed...
Source: Current Oncology - June 2, 2021 Category: Cancer & Oncology Authors: Megan M Tu Mark Clemons Carol Stober Ahwon Jeong Lisa Vandermeer Mihaela Mates Phillip Blanchette Anil Abraham Joy Olexiy Aseyev Gregory Pond Dean Fergusson Terry L Ng Kednapa Thavorn Source Type: research

Cost-Effectiveness Analysis of Stereotactic Ablative Body Radiotherapy for the Treatment of Oligometastatic Tumors versus Standard of Care
CONCLUSIONS: The adoption of SABR therapy requires a considerable upfront capital investment. Our results suggest that the cost-effectiveness of SABR is contingent on the uncertainty in the evidence base. Further clinical trials to confirm the effectiveness of SABR and research into the real-world costs associated with this treatment could reduce the uncertainty around implementation of the technology.PMID:34068400 | PMC:PMC8161824 | DOI:10.3390/curroncol28030172 (Source: Current Oncology)
Source: Current Oncology - June 2, 2021 Category: Cancer & Oncology Authors: Adam J N Raymakers David Cameron Scott Tyldesley Dean A Regier Source Type: research

Psychosocial Distress in Adult Patients Awaiting Cancer Surgery during the COVID-19 Pandemic
In this study, the psychosocial distress associated with waiting for cancer surgery during the pandemic was investigated. This cross-sectional, convergent mixed-methods study included patients with lower priority disease during the first wave of COVID-19 at an academic, tertiary care hospital in eastern Canada. Participants underwent semi-structured interviews and completed two questionnaires: Hospital Anxiety and Depression Scale (HADS) and Perceived Stress Scale (PSS). Qualitative analysis was completed through a thematic analysis approach, with integration achieved through triangulation. Fourteen participants were recru...
Source: Current Oncology - June 2, 2021 Category: Cancer & Oncology Authors: David Forner Sarah Murnaghan Geoffrey Porter Ross J Mason Paul Hong S Mark Taylor James Bentley Gregory Hirsch Christopher W Noel Matthew H Rigby Martin Corsten Jonathan R Trites Victoria Taylor Cynthia Kendell Margaret Jorgensen Robin Urquhart Source Type: research

Leukemia Cell Lines: In Vitro Models for the Study of Chronic Neutrophilic Leukemia
Curr Oncol. 2021 May 10;28(3):1790-1794. doi: 10.3390/curroncol28030166.ABSTRACTChronic neutrophilic leukemia (CNL) is a rare myeloproliferative neoplasm that is genetically characterized by the absence of both the Philadelphia chromosome and BCR-ABL1 fusion gene and the high prevalence of mutations in the colony-stimulating factor 3 receptor (CSF3R). Additional disease-modifying mutations have been recognized in CNL samples, portraying a distinct mutational landscape. Despite the growing knowledge base on genomic aberrations, further progress could be gained from the availability of representative models of CNL. To addres...
Source: Current Oncology - June 2, 2021 Category: Cancer & Oncology Authors: Hans G Drexler Stefan Nagel Hilmar Quentmeier Source Type: research

DNA Repair Gene Polymorphisms and Susceptibility to Urothelial Carcinoma in a Southeastern European Population
This study focused on three specific SNPs in a population with high exposure to environmental carcinogens including tobacco and alcohol. A case-control study design was used to assess for presence of XPC PAT +/-, XRCC3 Thr241Met, and ERCC2 Lys751Gln DNA repair gene SNPs in peripheral blood from patients with UCB and healthy individuals. One hundred patients and equal number of healthy subjects were enrolled. The XPC PAT +/+ genotype was associated with a 2-fold increased risk of UCB (OR = 2.16; 95%CI: 1.14-4; p = 0.01). The -/+ and +/+ XPC PAT genotypes were more frequently present in patients with multiple versus single t...
Source: Current Oncology - June 2, 2021 Category: Cancer & Oncology Authors: Maria Samara Maria Papathanassiou Lampros Mitrakas George Koukoulis Panagiotis J Vlachostergios Vassilios Tzortzis Source Type: research

Clinicopathological Risk Factors for Contralateral Lymph Node Metastases in Intraoral Squamous Cell Carcinoma: A Study of 331 Cases
Curr Oncol. 2021 May 14;28(3):1886-1898. doi: 10.3390/curroncol28030175.ABSTRACTThe current study aimed to examine the effects of clinicopathological factors, including the region, midline involvement, T classification, histological grade, and differentiation of the tumor on the rate of contralateral lymph node metastasis for oral squamous cell carcinoma and to assess their effects on survival rates. A total of 331 patients with intraoral squamous cell carcinomas were included. The influence of tumor location, T status, midline involvement, tumor grading, and the infiltration depth of the tumor on the pattern of metastasis...
Source: Current Oncology - June 2, 2021 Category: Cancer & Oncology Authors: Christian Fl örke Aydin G ülses Christina-Randi Altmann J örg Wiltfang Henning Wieker Hendrik Naujokat Source Type: research

Synovial Sarcoma: A Clinical Review
Curr Oncol. 2021 May 19;28(3):1909-1920. doi: 10.3390/curroncol28030177.ABSTRACTSynovial sarcomas (SS) represent a unique subset of soft tissue sarcomas (STS) and account for 5-10% of all STS. Synovial sarcoma differs from other STS by the relatively young age at diagnosis and clinical presentation. Synovial sarcomas have unique genomic characteristics and are driven by a pathognomonic t(X;18) chromosomal translocation and subsequent formation of the SS18:SSX fusion oncogenes. Similar to other STS, diagnosis can be obtained from a combination of history, physical examination, magnetic resonance imaging, biopsy and subseque...
Source: Current Oncology - June 2, 2021 Category: Cancer & Oncology Authors: Aaron M Gazendam Snezana Popovic Sohaib Munir Naveen Parasu David Wilson Michelle Ghert Source Type: research

Outcomes of Older Patients with Resectable Colorectal Liver Metastases Cancer (CRLM): Single Center Experience
Curr Oncol. 2021 May 18;28(3):1899-1908. doi: 10.3390/curroncol28030176.ABSTRACTSurgery is the only potential curative option of CRLM if resectable. The curative approach in patients over 70 years old is challenging mainly because of comorbidities and other geriatric syndromes. Herein, we report outcomes of older patients with resectable CRLM in our center. We retrospectively analyzed characteristics and outcomes of older patients with CRLM operated at "Centre Hospitalier de l'Université de Montréal" (CHUM) between 2010 and 2019. We identified 210 patients aged ≥70 years with a median age of 76 (...
Source: Current Oncology - June 2, 2021 Category: Cancer & Oncology Authors: Rami Nassabein Laura Mansour Corentin Richard Franck Vandenbroucke-Menu Francine Aubin Jean-Pierre Ayoub Michel Dagenais Real Lapointe Richard Letourneau Maryl ène Plasse Andr é Roy Simon Turcotte Mustapha Tehfe Source Type: research

An Example of Personalized Treatment in HR+ HER2+ Long Survivor Breast Cancer Patient (Case Report)
CONCLUSION: Our case report demonstrated the relevance of DDGI in clinical practice management of a patient treated for advanced breast cancer, suggesting the role of Drug-PIN software as an easy-to-use tool to prevent adverse events during cancer treatment and to help physicians in therapeutic algorithms. However, further studies are needed to confirm these results.PMID:34070464 | PMC:PMC8161821 | DOI:10.3390/curroncol28030184 (Source: Current Oncology)
Source: Current Oncology - June 2, 2021 Category: Cancer & Oncology Authors: Martina Panebianco Beatrice Taurelli Salimbeni Michela Roberto Paolo Marchetti Source Type: research

Lung Cancer Inequalities in Stage of Diagnosis in Ontario, Canada
Curr Oncol. 2021 May 23;28(3):1946-1956. doi: 10.3390/curroncol28030181.ABSTRACTLung cancer is the most common cancer and cause of cancer death in Canada, with approximately 50% of cases diagnosed at stage IV. Sociodemographic inequalities in lung cancer diagnosis have been documented, but it is not known if inequalities exist with respect to immigration status. We used multiple linked health-administrative databases to create a cohort of Ontarians 40-105 years of age who were diagnosed with an incident lung cancer between 1 April 2012 and 31 March 2017. We used modified Poisson regression with robust standard errors to ex...
Source: Current Oncology - June 2, 2021 Category: Cancer & Oncology Authors: Aisha K Lofters Evgenia Gatov Hong Lu Nancy N Baxter Sara J T Guilcher Alexander Kopp Mandana Vahabi Geetanjali D Datta Source Type: research

Geographic and Socioeconomic Disparity of Gastric Cancer Patients in Canada
Curr Oncol. 2021 May 28;28(3):2052-2064. doi: 10.3390/curroncol28030190.ABSTRACTGastric cancer is the 5th most common malignancy worldwide, representing ~5-10% of all new cancer cases. Although its incidence is declining, it is estimated that 1 in 98 Canadians will develop gastric cancer in their lifetime. The epidemiology and distribution of gastric cancer throughout Canada, however, remains poorly understood. A retrospective analysis of demographic data across Canada between 1992 and 2010 was performed using 2 population-based cancer registries. The incidence of gastric cancer was examined at the levels of provinces, cit...
Source: Current Oncology - June 2, 2021 Category: Cancer & Oncology Authors: Leila Cattelan Feras M Ghazawi Michelle Le Fran çois Lagacé Elham Rahme Andrei Zubarev Denis Sasseville Ivan V Litvinov Kevin A Waschke Elena Netchiporouk Source Type: research

Canadian Melanoma Conference Recommendations on High-Risk Melanoma Surveillance: A Report from the 14th Annual Canadian Melanoma Conference; Banff, Alberta; 20-22 February 2020
Conclusion: This final recommendation was established following 92% overall agreement among the 2020 CMC attendees.PMID:34072050 | PMC:PMC8161801 | DOI:10.3390/curroncol28030189 (Source: Current Oncology)
Source: Current Oncology - June 2, 2021 Category: Cancer & Oncology Authors: Christina W Lee J Gregory McKinnon Noelle Davis Source Type: research

Interventions and Outcomes for Neoadjuvant Treatment of T4 Colon Cancer: A Scoping Review
Curr Oncol. 2021 May 29;28(3):2065-2078. doi: 10.3390/curroncol28030191.ABSTRACTWhile adjuvant treatment of colon cancers that penetrate the serosa (T4) have been well-established, neoadjuvant strategies have yet to be formally evaluated. Our objective was to perform a scoping review of eligibility criteria, treatment regimens, and primary outcomes for neoadjuvant approaches to T4 colon cancer. A librarian-led, systematic search of MEDLINE, Embase, Cochrane Library, Web of Science, and CINAHL up to 11 February 2020 was performed. Primary research evaluating neoadjuvant treatment in T4 colon cancer were included. Screening ...
Source: Current Oncology - June 2, 2021 Category: Cancer & Oncology Authors: Flora Jung Keegan Guidolin Michael Ho-Yan Lee Kimberley Lam-Tin-Cheung Grace Zhao Sachin Doshi Tyler Chesney Marina Englesakis Jelena Lukovic Grainne O'Kane Fayez A Quereshy Sami A Chadi Source Type: research

Eastern Canadian Gastrointestinal Cancer Consensus Conference 2019
Curr Oncol. 2021 May 26;28(3):1988-2006. doi: 10.3390/curroncol28030185.ABSTRACTThe annual Eastern Canadian Gastrointestinal Cancer Consensus Conference 2019 was held in Morell, Prince Edward Island, 19-21 September 2019. Experts in medical oncology, radiation oncology, and surgical oncology who are involved in the management of patients with gastrointestinal malignancies participated in presentations and discussion sessions for the purpose of developing the recommendations presented here. This consensus statement addresses multiple topics in the management of anal, colorectal, biliary tract, and gastric cancers, including...
Source: Current Oncology - June 2, 2021 Category: Cancer & Oncology Authors: Joanna Gotfrit Rachel Goodwin Timothy Asmis Angela J Hyde Thierry Alcindor Francine Aubin Scott Berry Dominick Boss é Colin Brown Ronald Burkes Margot Burnell Bruce Colwell Jessica Corbett Jeff Craswell Nathalie Daaboul Mark Doherty D A Barry Fleming Lui Source Type: research

Ethical Considerations in Chemotherapy and Vaccines in Cancer Patients in Times of the COVID-19 Pandemic
Curr Oncol. 2021 May 26;28(3):2007-2013. doi: 10.3390/curroncol28030186.ABSTRACTThe COVID-19 situation is a worldwide health emergency with strong implications in clinical oncology. In this viewpoint, we address two crucial dilemmas from the ethical dimension: (1) Is it ethical to postpone or suspend cancer treatments which offer a statistically significant benefit in quality of life and survival in cancer patients during this time of pandemic?; (2) Should we vaccinate cancer patients against COVID-19 if scientific studies have not included this subgroup of patients? Regarding the first question, the best available evidenc...
Source: Current Oncology - June 2, 2021 Category: Cancer & Oncology Authors: Guido V Schiappacasse Source Type: research

Results from a Theory-Guided Survey to Support Breast Cancer Trial Participation: Barriers, Enablers, and What to Do about them
In this study, we surveyed subscribers to the Canadian Breast Cancer Network (CBCN) in order to identify a comprehensive list of theory-informed barriers and enablers relevant to participation in a hypothetical breast cancer trial.METHODS: We developed and conducted an online survey of breast cancer patients informed by the Theoretical Domains Framework and designed to determine previous experience with clinical trials, knowledge about clinical trials, and importance of a comprehensive list of barriers and enablers to trial participation. Participants were contacted by email or through social media.RESULTS: From 2451 subsc...
Source: Current Oncology - June 2, 2021 Category: Cancer & Oncology Authors: Jamie C Brehaut Kelly Carroll Jenn Gordon Justin Presseau Dawn P Richards Dean A Fergusson Ian D Graham Susan Marlin Source Type: research

Testing Mayo Clinic's New 20/20/20 Risk Model in Another Cohort of Smoldering Myeloma Patients: A Retrospective Study
Curr Oncol. 2021 May 26;28(3):2029-2039. doi: 10.3390/curroncol28030188.ABSTRACTBackground-smoldering multiple myeloma (SMM) risk of progression to multiple myeloma (MM) is highly heterogeneous and several models have been suggested to predict this risk. Lakshman et al. recently proposed a model based on three biomarkers: bone marrow plasma cell (BMPC) percentage> 20%, free light chain ratio (FLCr)> 20 and serum M protein> 20 g/L. The goal of our study was to test this "20/20/20" model in our population and to determine if similar results could be obtained in another cohort of SMM patients. Method-we con...
Source: Current Oncology - June 2, 2021 Category: Cancer & Oncology Authors: Camille Tessier Thomas Allard Jean-Samuel Boudreault Rayan Kaedbey Vincent Éthier Fl échère Fortin Michel Pavic Source Type: research

A Case of Pathological Complete Response and Resolution of Dermatomyositis Following Neoadjuvant Chemotherapy in HER2-Positive Early Breast Cancer
Discussion and conclusion. Similar cases in literature are commonly referred to a first-line surgery and the role of neoadjuvant chemotherapy is debatable.PMID:34073827 | PMC:PMC8161769 | DOI:10.3390/curroncol28030182 (Source: Current Oncology)
Source: Current Oncology - June 2, 2021 Category: Cancer & Oncology Authors: Marta Piras Martina Panebianco Matteo Garibaldi Michela Roberto Gioia Merlonghi Patrizia Pellegrini Paolo Marchetti Source Type: research

Investigation of Nano-Bio Interactions within a Pancreatic Tumor Microenvironment for the Advancement of Nanomedicine in Cancer Treatment
This study shows the paradigm-changing potential of NPs to combat the disease.PMID:34073974 | PMC:PMC8161808 | DOI:10.3390/curroncol28030183 (Source: Current Oncology)
Source: Current Oncology - June 2, 2021 Category: Cancer & Oncology Authors: Abdulaziz Alhussan Kyle Bromma Ece Pinar Demirci Bozdo ğan Andrew Metcalfe Joanna Karasinska Wayne Beckham Abraham S Alexander Daniel J Renouf David F Schaeffer Devika B Chithrani Source Type: research

Malignant Skin Cancer Excision in Combined Therapy with Electro-Chemotherapy and Dermal Substitute
This study shows that combined surgical selective excision with ECT and CDT is a valid technique for the extended-deep dorsal hand tumor lesions reconstruction.PMID:34063113 | PMC:PMC8161833 | DOI:10.3390/curroncol28030160 (Source: Current Oncology)
Source: Current Oncology - June 2, 2021 Category: Cancer & Oncology Authors: Barbara De Angelis Alberto Balzani Alessia Pagnotta Eleonora Tati Fabrizio Orlandi Margarida Fernandes Lopes Morais D'Autilio Valerio Cervelli Pietro Gentile Source Type: research

Successful Alectinib Treatment for Carcinoma of Unknown Primary with < em > EML4-ALK < /em > Fusion Gene: A Case Report
Curr Oncol. 2021 May 21;28(3):1938-1945. doi: 10.3390/curroncol28030180.ABSTRACTGene alteration in anaplastic lymphoma kinase (ALK) is rare, and the efficacy of ALK inhibitors in the treatment of carcinoma of unknown primary (CUP) with ALK alteration remains unclear. The patient was a 56-year-old woman who presented with cervical lymph node swelling. Computed tomography revealed paraaortic, perigastric, and cervical lymph node swelling; ascites; a liver lesion; and a left adrenal mass. A cervical lymph node biopsy was performed, and pathological diagnosis of an undifferentiated malignant tumor was conducted. Finally, the p...
Source: Current Oncology - June 2, 2021 Category: Cancer & Oncology Authors: Keiji Sugiyama Ai Izumika Akari Iwakoshi Riko Nishibori Mariko Sato Kazuhiro Shiraishi Hiroyoshi Hattori Rieko Nishimura Chiyoe Kitagawa Source Type: research

Cost Analysis of Laparoscopic Low Anterior Resection vs. Transanal Endoscopic Microsurgery for Rectal Neoplasms
This study compares the cost of TEM to laparoscopic low anterior resection (LAR). Patients who underwent laparoscopic LAR (n = 24) for rectal neoplasm between 2006 and 2014 were case-matched based on sex, age, comorbidities, lesion size and location to patients who underwent TEM at a busy secondary care urban hospital. Procedure-related costs and costs associated with readmissions for complications and related subsequent surgeries in the first 3 years were calculated. There were 42 hospital admissions for 24 LAR patients, totalling 326 hospital days. For 24 TEM patients, there were 25 hospital admissions, totalling 56 hosp...
Source: Current Oncology - June 2, 2021 Category: Cancer & Oncology Authors: Katerina Neumann Nirmal Randhawa Jason Park David J Hochman Source Type: research

Current Landscape of Targeted Therapy in Hormone Receptor-Positive and HER2-Negative Breast Cancer
Discussion: Targeted treatment options for HR + BC have evolved. The future of overcoming resistance to targeted therapy, novel compounds, and predictive markers are key to improving HR + BC outcomes.PMID:34064867 | PMC:PMC8161804 | DOI:10.3390/curroncol28030168 (Source: Current Oncology)
Source: Current Oncology - June 2, 2021 Category: Cancer & Oncology Authors: Samitha Andrahennadi Amer Sami Mita Manna Mehrnoosh Pauls Shahid Ahmed Source Type: research

Cytoreductive Nephrectomy Following Immunotherapy-Base Treatment in Metastatic Renal Cell Carcinoma: A Case Series and Review of Current Literature
Curr Oncol. 2021 May 20;28(3):1921-1926. doi: 10.3390/curroncol28030178.ABSTRACTThe role and timing of cytoreductive nephrectomy in patients with metastatic renal cell carcinoma receiving immunotherapy-based regimens is unclear. However, the ability to achieve a complete response for metastatic renal cell carcinoma likely requires a nephrectomy at some point during treatment. Here we present a case series of three patients with metastatic clear-cell renal-cell carcinoma who received front-line immunotherapy-based treatment and subsequently underwent a cytoreductive nephrectomy. All three patients had a complete response to...
Source: Current Oncology - June 2, 2021 Category: Cancer & Oncology Authors: Scott J Dawsey Steven C Campbell Moshe C Ornstein Source Type: research

Cancer Testis Antigen, NOL4, Is an Immunogenic Antigen Specifically Expressed in Small-Cell Lung Cancer
Curr Oncol. 2021 May 20;28(3):1927-1937. doi: 10.3390/curroncol28030179.ABSTRACTTo identify cancer/testis (CT) antigens and immunogenic proteins, immunoscreening of testicular and small-cell lung cancer cell line NCI-H889 cDNA libraries was performed using serum obtained from a small-cell lung cancer (SCLC) patient. We obtained 113 positive cDNA clones comprised of 74 different genes, designated KP-SCLC-1 through KP-SCLC-74. Of these genes, 59 genes were found to be related to cancers by EMBASE analysis. Three of these antigens, including KP-SCLC-29 (NOL4), KP-SCLC-59 (CCDC83), and KP-SCLC-69 (KIF20B), were CT antigens. RT...
Source: Current Oncology - June 2, 2021 Category: Cancer & Oncology Authors: Ye-Rin Kim Ki-Uk Kim Jung-Hee Lee Deok-Won Kim Jae-Heun Chung Yeong-Dae Kim Dong-Hoon Shin Min-Ki Lee Yong-Il Shin Sang-Yull Lee Source Type: research

Diagnostic Performance of PI-RADS v2, Proposed Adjusted PI-RADS v2 and Biparametric Magnetic Resonance Imaging for Prostate Cancer Detection: A Preliminary Study
CONCLUSIONS: The overall diagnostic performance of the three protocols showed minimal differences. For lesions assessed as being category 3 using the biparametric MRI protocol, PI-RADS v2, or PA PI-RADS v2, it was thought prostate cancer detection could be improved. Attention should be paid to false positive results when PI-RADS v2 or PA PI-RADS v2 are used.PMID:34065851 | PMC:PMC8161832 | DOI:10.3390/curroncol28030169 (Source: Current Oncology)
Source: Current Oncology - June 2, 2021 Category: Cancer & Oncology Authors: Guan-Hui Cai Qi-Hua Yang Wen-Bo Chen Qing-Yu Liu Yu-Rong Zeng Yu-Jing Zeng Source Type: research

Cancer Screening Interventions in Indigenous Populations: A Rapid Review
Curr Oncol. 2021 May 6;28(3):1728-1743. doi: 10.3390/curroncol28030161.ABSTRACTCancer screening is an important component of a cancer control strategy. Indigenous people in Canada have higher incidence rates for many types of cancer, including those that can be detected early or prevented through organized screening programs. Increased participation and retention in cancer screening is critical to improved population health outcomes amongst Indigenous people. This rapid review evaluates cancer screening interventions published in the last six years. Included studies demonstrated increased participation in breast, colorecta...
Source: Current Oncology - June 2, 2021 Category: Cancer & Oncology Authors: Janell Bryant Kara Patterson Marcus Vaska Bonnie Chiang Angeline Letendre Lea Bill Huiming Yang Karen Kopciuk Source Type: research

Impact of an Augmented Reality Navigation System (SIRIO) on Bone Percutaneous Procedures: A Comparative Analysis with Standard CT-Guided Technique
Curr Oncol. 2021 May 8;28(3):1751-1760. doi: 10.3390/curroncol28030163.ABSTRACT(1) Background: The purpose of this study is to evaluate the impact of an augmented reality navigation system (SIRIO) for percutaneous biopsies and ablative treatments on bone lesions, compared to a standard CT-guided technique. (2) Methods: Bioptic and ablative procedures on bone lesions were retrospectively analyzed. All procedures were divided into SIRIO and Non-SIRIO groups and in 2 cm groups. Number of CT-scans, procedural time and patient's radiation dose were reported for each group. Diagnostic accuracy was obtained for bioptic procedures...
Source: Current Oncology - June 2, 2021 Category: Cancer & Oncology Authors: Eliodoro Faiella Gennaro Castiello Caterina Bernetti Giuseppina Pacella Carlo Altomare Flavio Andresciani Bruno Beomonte Zobel Rosario Francesco Grasso Source Type: research

Activity and Safety of NAB-FOLFIRI and NAB-FOLFOX as First-Line Treatment for metastatic Pancreatic Cancer (NabucCO Study)
CONCLUSION: Nab-FOLFIRI and Nab-FOLFOX might be hopeful first-line CT options for mPC patients, with promising activity and a good safety profile.PMID:34066784 | PMC:PMC8161763 | DOI:10.3390/curroncol28030164 (Source: Current Oncology)
Source: Current Oncology - June 2, 2021 Category: Cancer & Oncology Authors: Elisa Giommoni Evaristo Maiello Vanja Vaccaro Ermanno Rondini Caterina Vivaldi Giampaolo Tortora Laura Toppo Guido Giordano Tiziana Pia Latiano Cinzia Lamperini Serena Pillozzi Luca Boni Lorenzo Antonuzzo Francesco Di Costanzo Source Type: research

Predictors of Urgent Cancer Care Clinic and Emergency Department Visits for Individuals Diagnosed with Cancer
Curr Oncol. 2021 May 8;28(3):1773-1789. doi: 10.3390/curroncol28030165.ABSTRACTIn 2013, CancerCare Manitoba (CCMB) launched an urgent cancer care clinic (UCC) to meet the needs of individuals diagnosed with cancer experiencing acute complications of cancer or its treatment. This retrospective cohort study compared the characteristics of individuals diagnosed with cancer that visited the UCC to those who visited an emergency department (ED) and determined predictors of use. Multivariable logistic mixed models were run to predict an individual's likelihood of visiting the UCC or an ED. Scaled Brier scores were calculated to ...
Source: Current Oncology - June 2, 2021 Category: Cancer & Oncology Authors: Kathleen Decker Pascal Lambert Katie Galloway Oliver Bucher Marshall Pitz Benjamin Goldenberg Harminder Singh Mark Kristjanson Tunji Fatoye Eric J Bow Source Type: research

Stereotactic Radiotherapy in the Treatment of Paraneoplastic Vasculitis in Oligometastatic Renal Cell Carcinoma
We present a case of a previously healthy male who presented with systemic vasculitis; bitemporal headaches, diplopia, polyarthritis, palpable purpura, tongue lesion, peri-orbital edema, scleritis, chondritis and constitutional symptoms. He was subsequently found to have oligometastatic RCC. Both his primary lesion and site of oligometastasis were treated with stereotactic radiotherapy (SBRT) and resulted in the resolution of his vasculitis, as well as sustained oncologic response. This is the first case to demonstrate that effective sustained treatment for PNS vasculitis due to oligometastatic RCC is possible with SBRT.PM...
Source: Current Oncology - June 2, 2021 Category: Cancer & Oncology Authors: Laura Burgess Marissa Keenan Alan Liang Zhou Kiefer Lypka Delvina Hasimja Saraqini Jeff Yao Samuel Martin Christopher Morash James Watterson Christina Canil Robert MacRae Source Type: research

Re-Irradiation for Locally Recurrent Lung Cancer: A Single Center Retrospective Analysis
Curr Oncol. 2021 May 13;28(3):1835-1846. doi: 10.3390/curroncol28030170.ABSTRACTThe treatment of locally recurrent lung cancer is a major challenge for radiation-oncologists, especially with data on high-dose reirradiation being limited to small retrospective studies. The aim of the present study is to assess overall survival (OS) for patients with locally recurrent lung cancer after high-dose thoracic reirradiation. Thirty-nine patients who were re-irradiated for lung cancer relapse between October 2013 and February 2019 were eligible for the current retrospective analysis. All patients were re-irradiated with curative in...
Source: Current Oncology - June 2, 2021 Category: Cancer & Oncology Authors: Brane Grambozov Evelyn Nussdorfer Julia Kaiser Sabine Gerum Gerd Fastner Markus Stana Christoph Gaisberger Romana Wass Michael Studnicka Felix Sedlmayer Franz Zehentmayr Source Type: research

Cost-Effectiveness Analysis of 12-Versus 4-Weekly Administration of Bone-Targeted Agents in Patients with Bone Metastases from Breast and Castration-Resistant Prostate Cancer
Curr Oncol. 2021 May 13;28(3):1847-1856. doi: 10.3390/curroncol28030171.ABSTRACTA cost-utility analysis was performed based on the Rethinking Clinical Trials (REaCT) bone-targeted agents (BTA) clinical trial that compared 12-weekly (once every 12 weeks) (n = 130) versus 4-weekly (once every 4 weeks) (n = 133) BTA dosing for metastatic breast and castration-resistant prostate (CRPC) cancer. Using a decision tree model, we calculated treatment and symptomatic skeletal event (SSE) costs as well as quality-adjusted life-years (QALYs) for each treatment option. Deterministic and probabilistic sensitivity analyses were performed...
Source: Current Oncology - June 2, 2021 Category: Cancer & Oncology Authors: Megan M Tu Mark Clemons Carol Stober Ahwon Jeong Lisa Vandermeer Mihaela Mates Phillip Blanchette Anil Abraham Joy Olexiy Aseyev Gregory Pond Dean Fergusson Terry L Ng Kednapa Thavorn Source Type: research

Cost-Effectiveness Analysis of Stereotactic Ablative Body Radiotherapy for the Treatment of Oligometastatic Tumors versus Standard of Care
CONCLUSIONS: The adoption of SABR therapy requires a considerable upfront capital investment. Our results suggest that the cost-effectiveness of SABR is contingent on the uncertainty in the evidence base. Further clinical trials to confirm the effectiveness of SABR and research into the real-world costs associated with this treatment could reduce the uncertainty around implementation of the technology.PMID:34068400 | PMC:PMC8161824 | DOI:10.3390/curroncol28030172 (Source: Current Oncology)
Source: Current Oncology - June 2, 2021 Category: Cancer & Oncology Authors: Adam J N Raymakers David Cameron Scott Tyldesley Dean A Regier Source Type: research

Psychosocial Distress in Adult Patients Awaiting Cancer Surgery during the COVID-19 Pandemic
In this study, the psychosocial distress associated with waiting for cancer surgery during the pandemic was investigated. This cross-sectional, convergent mixed-methods study included patients with lower priority disease during the first wave of COVID-19 at an academic, tertiary care hospital in eastern Canada. Participants underwent semi-structured interviews and completed two questionnaires: Hospital Anxiety and Depression Scale (HADS) and Perceived Stress Scale (PSS). Qualitative analysis was completed through a thematic analysis approach, with integration achieved through triangulation. Fourteen participants were recru...
Source: Current Oncology - June 2, 2021 Category: Cancer & Oncology Authors: David Forner Sarah Murnaghan Geoffrey Porter Ross J Mason Paul Hong S Mark Taylor James Bentley Gregory Hirsch Christopher W Noel Matthew H Rigby Martin Corsten Jonathan R Trites Victoria Taylor Cynthia Kendell Margaret Jorgensen Robin Urquhart Source Type: research

Leukemia Cell Lines: In Vitro Models for the Study of Chronic Neutrophilic Leukemia
Curr Oncol. 2021 May 10;28(3):1790-1794. doi: 10.3390/curroncol28030166.ABSTRACTChronic neutrophilic leukemia (CNL) is a rare myeloproliferative neoplasm that is genetically characterized by the absence of both the Philadelphia chromosome and BCR-ABL1 fusion gene and the high prevalence of mutations in the colony-stimulating factor 3 receptor (CSF3R). Additional disease-modifying mutations have been recognized in CNL samples, portraying a distinct mutational landscape. Despite the growing knowledge base on genomic aberrations, further progress could be gained from the availability of representative models of CNL. To addres...
Source: Current Oncology - June 2, 2021 Category: Cancer & Oncology Authors: Hans G Drexler Stefan Nagel Hilmar Quentmeier Source Type: research

DNA Repair Gene Polymorphisms and Susceptibility to Urothelial Carcinoma in a Southeastern European Population
This study focused on three specific SNPs in a population with high exposure to environmental carcinogens including tobacco and alcohol. A case-control study design was used to assess for presence of XPC PAT +/-, XRCC3 Thr241Met, and ERCC2 Lys751Gln DNA repair gene SNPs in peripheral blood from patients with UCB and healthy individuals. One hundred patients and equal number of healthy subjects were enrolled. The XPC PAT +/+ genotype was associated with a 2-fold increased risk of UCB (OR = 2.16; 95%CI: 1.14-4; p = 0.01). The -/+ and +/+ XPC PAT genotypes were more frequently present in patients with multiple versus single t...
Source: Current Oncology - June 2, 2021 Category: Cancer & Oncology Authors: Maria Samara Maria Papathanassiou Lampros Mitrakas George Koukoulis Panagiotis J Vlachostergios Vassilios Tzortzis Source Type: research