Comprehensive Genomic Profiling of Circulating Cell-Free DNA Distinguishes Focal < em > MET < /em > Amplification from Aneuploidy in Diverse Advanced Cancers
This study describes an approach to distinguish focal and non-focal MET amplification using comprehensive genomic profiling of cfDNA in advanced cancer patients. Focal MET amp accounted for ~30% of all MET amp, which was found in 3.7% of patients with diverse cancers and was associated with a higher plasma copy number. Clinical studies are warranted to assess the clinical utility of targeted therapies for tumors with focal MET amplification detected by NGS of cfDNA.PMID:34677235 | PMC:PMC8534719 | DOI:10.3390/curroncol28050317 (Source: Current Oncology)
Source: Current Oncology - October 22, 2021 Category: Cancer & Oncology Authors: Yuichi Kumaki Steve Olsen Mitsukuni Suenaga Tsuyoshi Nakagawa Hiroyuki Uetake Sadakatsu Ikeda Source Type: research

Clinical Outcomes from Dose-Reduced Radiotherapy to the Prostate in Elderly Patients with Localized Prostate Cancer
This study reports on a cohort of 54 elderly (>70 years) patients that received 4000-5000 cGy of palliative external beam radiotherapy (EBRT) as an alternative to androgen deprivation therapy (ADT). The primary outcome of interest was the period of ADT-free survival, and secondary outcomes included overall survival (OS) and metastases-free survival (MFS). Kaplan-Meier regression was used to estimate survival outcomes. Thirty-six (67%) patients achieved a break in ADT post-radiotherapy, with a median time to ADT reinitiation of 20 months. Common Terminology Criteria for Adverse Events (CTCAE) were limited to low-grade ga...
Source: Current Oncology - October 22, 2021 Category: Cancer & Oncology Authors: Nina Samson Rutvij A Khanolkar Sarah Quirk Harvey Quon Michael Roumeliotis Alex Balogh Michael Sia Kundan Thind Siraj Husain Kevin Martell Source Type: research

Risk Factors of Duodenobiliary Reflux-Related Dysfunction of Covered Biliary Metal Stents after Treatment of Duodenal Stricture in Patients with Malignant Biliary and Duodenal Obstruction
Curr Oncol. 2021 Sep 26;28(5):3738-3747. doi: 10.3390/curroncol28050319.ABSTRACTDuodenal obstruction is often accompanied with unresectable malignant distal biliary obstruction in patients who have undergone biliary self-expandable metal stent (SEMS) placement. Duodenobiliary reflux (DBR) is a major cause of recurrent biliary obstruction (RBO) after covered biliary SEMS placement. We analyzed the risk factors for DBR-related SEMS dysfunction following treatment for malignant duodenal obstruction. Sixty-one patients with covered SEMS who underwent treatment for duodenal obstruction were included. We excluded patients with t...
Source: Current Oncology - October 22, 2021 Category: Cancer & Oncology Authors: Chi-Huan Wu Mu-Hsien Lee Yung-Kuan Tsou Cheng-Hui Lin Kai-Feng Sung Kuang-Tse Pan Nai-Jen Liu Source Type: research

The Surgical Management of Proximal Femoral Metastases: A Narrative Review
Curr Oncol. 2021 Sep 28;28(5):3748-3757. doi: 10.3390/curroncol28050320.ABSTRACTThe proximal femur is a common location for the development of bony metastatic disease. Metastatic bone disease in this location can cause debilitating pain, pathologic fractures, reduced quality of life, anemia or hypercalcemia. A thorough history, physical examination and preoperative investigations are required to ensure accurate diagnosis and prognosis. The goals of surgical management is to provide pain relief and return to function with a construct that provides stability to allow for immediate weightbearing. Current surgical treatment op...
Source: Current Oncology - October 22, 2021 Category: Cancer & Oncology Authors: Daniel Axelrod Aaron M Gazendam Michelle Ghert Source Type: research

Global DNA 5hmC and CK19 < sup > 5hmC+ < /sup > Contents: A Promising Biomarker for Predicting Prognosis in Small Hepatocellular Carcinoma
This study applied ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) in measuring 5mC, 5fC and 5hmC contents. In addition, immunohistochemistry (IHC) was adopted to measure CK19 and 5hmC contents.RESULTS: Research showed 5mC, 5hmC, and 5fC contents from global genomics of SHCC reduced extensively compared with healthy samples (p
Source: Current Oncology - October 22, 2021 Category: Cancer & Oncology Authors: Jinhua Jiang Tinghua Yan Fang Guo Source Type: research

Assessment of Risk of Bias in Osteosarcoma and Ewing's Sarcoma Randomized Controlled Trials: A Systematic Review
Curr Oncol. 2021 Sep 28;28(5):3771-3794. doi: 10.3390/curroncol28050322.ABSTRACTAIM: The aim of this study was to systematically assess the risk of bias in osteosarcoma and Ewing's sarcoma (ES) randomized controlled trials (RCT) and to examine the relationships between bias and conflict of interest/industry sponsorship.METHODS: An OVID-MEDLINE search was performed (1976-2019). Using the Cochrane Collaboration guidelines, two reviewers independently assessed the prevalence of risk of bias in different RCT design domains. The relationship between conflicts of interest and industry funding with the frequency of bias was exami...
Source: Current Oncology - October 22, 2021 Category: Cancer & Oncology Authors: Robert Koucheki Aaron M Gazendam Jonathan R Perera Anthony Griffin Peter Ferguson Jay Wunder Kim Tsoi Source Type: research

Acceptance of Psycho-Oncological Counseling Formats in a Cancer Counseling Center during the COVID-19 Pandemic: An Exploratory Care Study
CONCLUSION: On the basis of this survey, it can be concluded that digital counseling formats were perceived by patients as a promising addition to the classic face-to-face setting. In addition, it can be stated that the digital formats (telephone and video) were not generally preferred to face-to-face counseling, but that the innovative telecounseling was accepted and perceived with great satisfaction and acceptance. Accordingly, the additional use of digital counseling formats could be an opportunity to enrich and expand the existing presence structures also after the COVID-19 pandemic.PMID:34677241 | PMC:PMC8535020 | DOI...
Source: Current Oncology - October 22, 2021 Category: Cancer & Oncology Authors: Jacqueline Lohmiller Norbert Sch äffeler Heike S ütterlin Stephan Zipfel Andreas Stengel Source Type: research

Feasibility of Stereotactic Body Radiation Therapy on Unresectable Stage III NSCLC with Peripheral Primary Tumor: A Prospective Study (GFPC 01-14)
Curr Oncol. 2021 Sep 28;28(5):3804-3811. doi: 10.3390/curroncol28050324.ABSTRACTConcomitant radiochemotherapy (RTCT) is the standard treatment for unresectable stage III non-small cell lung cancer (NSCLC). However, in patients with a peripheral primary tumor, the irradiated volume may include a large portion of normal lung and RT-CT is not possible. This multicenter phase II trial in unresectable stage III NSCLC with peripheral primary tumor evaluated the feasibility of stereotactic body radiation therapy (SBRT) in peripheral tumor after concomitant radio-chemotherapy (RT-CT). Nineteen patients were included and analyzed (...
Source: Current Oncology - October 22, 2021 Category: Cancer & Oncology Authors: Isabelle Martel-Lafay Isabelle Monnet Audrey Lardy-Cleaud Serge Danhier Naji Salem Olivier Gallocher Pierre Fournel Christos Chouaid Olivier Bylicki None The Gfpc-Investigators Source Type: research

Survival Outcomes Associated with First and Second-Line Palliative Systemic Therapies in Patients with Metastatic Bladder Cancer
This study investigates current trends in treating mBC with first- (1L) and second-line (2L) chemotherapy (CT) and immunotherapy (IT).METHODS: A chart review was conducted on patients diagnosed with stage II-IV bladder cancer in 2014-2016. Survival outcomes were compared between chemotherapy, immunotherapy, and supportive care.RESULTS: out of 297 patients, 77% were male. 44% had stage IV disease at diagnosis. Median age at metastasis was 73 years. 40% of patients received 1L PST and 34% received 2L PST. Median overall survival (mOS) was longer in those receiving PST versus no treatment (p 1.5 years in mBC is unprecedented ...
Source: Current Oncology - October 22, 2021 Category: Cancer & Oncology Authors: Arshia Beigi Saba Vafaei-Nodeh Longlong Huang Shaun Z Sun Jenny J Ko Source Type: research

Frontline Treatment of the Young, Fit Patient with CLL: A Canadian Perspective
Curr Oncol. 2021 Sep 30;28(5):3825-3835. doi: 10.3390/curroncol28050326.ABSTRACTFrom a Canadian perspective, there has been a limited discussion on the frontline management of young, fit patients with chronic lymphocytic leukemia (CLL). The prevalence of this population ranges between 2 and 22 per 100,000 persons in Canada and varies by region. Until recently, fixed-duration fludarabine-based chemoimmunotherapy (CIT) was the primary treatment option in Canada for this patient population. The ECOG1912 trial has since demonstrated that ibrutinib and rituximab therapy are as effective as fludarabine-cyclophosphamide-rituximab...
Source: Current Oncology - October 22, 2021 Category: Cancer & Oncology Authors: Jacqueline Costello Matthew Kang Versha Banerji Source Type: research

Expression of Senescence and Apoptosis Biomarkers in Synchronous Bilateral Breast Cancer: A Case Report
CONCLUSIONS: Our results highlight the variable expression of senescence- and apoptosis-associated markers in breast tumors (despite the shared somatic genetic background) and invites a large-scale assessment of both senescence and apoptosis in breast cancer tissue in vivo and their contribution to the pathological response and overall survival.PMID:34677245 | PMC:PMC8535022 | DOI:10.3390/curroncol28050327 (Source: Current Oncology)
Source: Current Oncology - October 22, 2021 Category: Cancer & Oncology Authors: Tareq Saleh Mohammed El-Sadoni Ahmad Alhesa Heyam Awad Mahmoud Jaradat Mohammad Al-Hazaimeh Rand Dawoud Amel Mryyian Bilal Azab Source Type: research

Prognostic Radiological Tools for Clinical Stage IA Pure Solid Lung Cancer
In this study, we analyzed prognostic radiological tools and surgical outcomes for radiologically pure solid adenocarcinomas (AD) and squamous cell carcinoma (SQ) in clinical stage IA. We retrospectively investigated 130 patients who underwent surgical resections. We assessed the predictive risk factors for recurrence and pathological lymph node metastasis (LNM). There was no statistical difference in recurrence free survival (RFS) or cancer-specific survival (CSS) between AD and SQ groups (p = 0.642 and p = 0.403, respectively). In the whole cohort, tumor size on lung window and mediastinal settings, and tumor disappearan...
Source: Current Oncology - October 22, 2021 Category: Cancer & Oncology Authors: Takeo Nakada Yusuke Takahashi Noriaki Sakakura Hiroshi Iwata Takashi Ohtsuka Hiroaki Kuroda Source Type: research

CRAFT-A Proposed Framework for Decentralized Clinical Trials Participation in Canada
Curr Oncol. 2021 Sep 30;28(5):3857-3865. doi: 10.3390/curroncol28050329.ABSTRACTCanada's vast geography, and centralized delivery of cancer care and clinical trials create barriers for trial participation for patients in remote and rural settings. The development and implementation of a framework that enables safe and regulatory compliant trial participation through local healthcare providers would benefit Canadian patients, clinicians, trial sponsors and the health care system. To address this issue, representatives of Canada's cancer clinical trial community met to identify key challenges and develop recommendations for ...
Source: Current Oncology - October 22, 2021 Category: Cancer & Oncology Authors: Stephen Sundquist Gerald Batist Kathy Brodeur-Robb Kathryn Dyck Bernhard J Eigl David K Lee Jaqueline Limoges Holly Longstaff Jim Pankovich Anna Sadura Patrick Sullivan Janet E Dancey Source Type: research

The Challenge of Return to Work after Breast Cancer: The Role of Family Situation, CANTO Cohort
Curr Oncol. 2021 Oct 1;28(5):3866-3875. doi: 10.3390/curroncol28050330.ABSTRACTReturn to work (RTW) after breast cancer is associated with improved quality of life. The link between household characteristics and RTW remains largely unknown. The aim of this study was to examine the effect of the family situation on women's RTW two years after breast cancer. We used data of a French prospective cohort of women diagnosed with stage I-III, primary breast cancer (CANTO, NCT01993498). Among women employed at diagnosis and under 57 years old, we assessed the association between household characteristics (living with a partner, ma...
Source: Current Oncology - October 22, 2021 Category: Cancer & Oncology Authors: Elsa Caumette In ès Vaz-Luis Sandrine Pinto Julie Havas Thomas Bovagnet Garazi Ruiz de Azua Antonio Di Meglio Anne-Laure Martin Sibille Everhard Paul Cottu Laurence Vanlemmens Christelle Jouannaud Florence Lerebours Agn ès Dumas Gwenn Menvielle Source Type: research

Prognostic Factors Influencing Survival and a Treatment Pattern Analysis of Conventional Palliative Radiotherapy for Patients with Bone Metastases
CONCLUSIONS: Based on the prognostic factors we identified, a selection protocol for patients candidates for palliative radiotherapy to bone metastases could be established, in order to further increase SFRT prescription in our institution.PMID:34677249 | PMC:PMC8534390 | DOI:10.3390/curroncol28050331 (Source: Current Oncology)
Source: Current Oncology - October 22, 2021 Category: Cancer & Oncology Authors: Patricia Ignat Nicolae Todor Radu-Mihai Ignat Ofelia Șuteu Source Type: research

Spinal Manifestation of Malignant Primary (PLB) and Secondary Bone Lymphoma (SLB)
Curr Oncol. 2021 Oct 2;28(5):3891-3899. doi: 10.3390/curroncol28050332.ABSTRACTManifestation of malignant lymphoma in the spine is rare; there have only been a few cases reported in the literature. Due to its rarity, there is no gold standard for the management of patients suffering from spinal lymphoma manifestations. Methods: We retrospectively reviewed the data for 37 patients (14 female, 23 male) with malignant lymphoma in the spine receiving intervention in our center from March 2006 until June 2020. Neurological impairment, pain, diagnostics, and/or surgical instability were the criteria for surgery in this patient c...
Source: Current Oncology - October 22, 2021 Category: Cancer & Oncology Authors: Melanie Barz Kaywan Aftahy Insa Janssen Yu-Mi Ryang Georg Prokop Stephanie E Combs Philipp J Jost Bernhard Meyer Jens Gempt Source Type: research

Treatment Regret, Mental and Physical Health Indicators of Psychosocial Well-Being among Prostate Cancer Survivors
Curr Oncol. 2021 Oct 2;28(5):3900-3917. doi: 10.3390/curroncol28050333.ABSTRACTProstate cancer (PCa) patients and survivors are at high risk of mental health illness. Here, we examined the contribution of treatment regret, mental and physical health indicators to the social/family, emotional, functional and spiritual well-being of PCa survivors. The study assessed 367 men with a history of PCa residing in the Maritimes Canada who were surveyed between 2017 and 2021. The outcomes were social/family, emotional, functional and spiritual well-being (FACT-P,FACIT-Sp). Predictor variables included urinary, bowel and sexual funct...
Source: Current Oncology - October 22, 2021 Category: Cancer & Oncology Authors: Cassidy Bradley Gabriela Ilie Cody MacDonald Lia Massoeurs Jasmine Dang Cam-Tu Vo Robert David Harold Rutledge Source Type: research

Psychosocial and Functional Predictors of Mental Disorder among Prostate Cancer Survivors: Informing Survivorship Care Programs with Evidence-Based Knowledge
Curr Oncol. 2021 Oct 3;28(5):3918-3931. doi: 10.3390/curroncol28050334.ABSTRACTRecent research has revealed that prostate cancer (PCa) survivors are facing a silent epidemic of mental disorder. These findings are not surprising when the side effects of highly effective current treatment modalities are considered. Here, we assess the association between urinary function and quality of life indicators to mental disorder among survivors of PCa. This is a cross sectional examination of an analytical sample of 362 men with a history of PCa residing in the Maritimes who took a survey assessing social, physical and health-related...
Source: Current Oncology - October 22, 2021 Category: Cancer & Oncology Authors: Lia Massoeurs Gabriela Ilie Tarek Lawen Cody MacDonald Cassidy Bradley Jasmine Dang Cam-Tu Vo Robert David Harold Rutledge Source Type: research

Intraoperative Radiotherapy with Balloon-Based Electronic Brachytherapy System-A Systematic Review and First Bulgarian Experience in Breast Cancer Patients
Conclusions: Current evidence demonstrates the Xoft Axxent® eBx system as a safe and feasible technique for IORT delivery in EBC patients. There are no randomized controlled trials conducted at this time point to prove its long-term effectiveness. Better patient selection and a reimbursement strategy have to be proposed to extend the application of this technique in Bulgaria.PMID:34677253 | PMC:PMC8534590 | DOI:10.3390/curroncol28050335 (Source: Current Oncology)
Source: Current Oncology - October 22, 2021 Category: Cancer & Oncology Authors: Desislava Kostova-Lefterova Mariela Vasileva-Slaveva Svilen Maslyankov Assia Konsoulova Margarita Atanasova Tsvetelina Paycheva Alexandrina Vlahova Marusya Genadieva-Yordanova Ginka Prodanova Zahari Zahariev Vasil Pavlov Georgi Todorov Boris Vasilev Kosta Source Type: research

Combined Exoscopic and Endoscopic Technique for Craniofacial Resection
Curr Oncol. 2021 Oct 4;28(5):3945-3958. doi: 10.3390/curroncol28050336.ABSTRACTWe determined the feasibility of the combined exoscopic-endoscopic technique (CEE) as an alternative to the microscope in craniofacial resection (CFR). This retrospective study was conducted at a single institution and included eight consecutive patients with head and neck tumors who underwent CFR between September 2019 and July 2021. During the transcranial approach, microsurgery was performed using an exoscope in the same manner as in traditional microscopic surgery, and an endoscope was used at the blind spot of the exoscope. The exoscope pro...
Source: Current Oncology - October 22, 2021 Category: Cancer & Oncology Authors: Kenichiro Iwami Tadashi Watanabe Koji Osuka Tetsuya Ogawa Shigeru Miyachi Yasushi Fujimoto Source Type: research

The Rethinking Clinical Trials (REaCT) Program. A Canadian-Led Pragmatic Trials Program: Strategies for Integrating Knowledge Users into Trial Design
Curr Oncol. 2021 Oct 4;28(5):3959-3977. doi: 10.3390/curroncol28050337.ABSTRACTWe reviewed patient and health care provider (HCP) surveys performed through the REaCT program. The REaCT team has performed 15 patient surveys (2298 respondents) and 13 HCP surveys (1033 respondents) that have addressed a broad range of topics in breast cancer management. Over time, the proportion of surveys distributed by paper/regular mail has fallen, with electronic distribution now the norm. For the patient surveys, the median duration of the surveys was 3 months (IQR 2.5-7 months) and the median response rate was 84% (IQR 80-91.7%). For th...
Source: Current Oncology - October 22, 2021 Category: Cancer & Oncology Authors: Deanna Saunders Michelle Liu Lisa Vandermeer Mashari Jemaan Alzahrani Brian Hutton Mark Clemons Source Type: research

Real World Outcomes in Patients with Advanced Melanoma Treated in Alberta, Canada: A Time-Era Based Analysis
Curr Oncol. 2021 Oct 5;28(5):3978-3986. doi: 10.3390/curroncol28050338.ABSTRACTImmune checkpoint and MAP kinase pathway inhibitors can significantly improve long-term survival for patients with melanoma. There is limited real-world data of these regimens' effectiveness. We retrospectively analyzed 402 patients with unresectable and metastatic melanoma between August 2013 and July 2020 treated with immune checkpoint inhibitors and MAP kinase pathway targeted therapy in Alberta, Canada. Overall survival (OS) was compared using Kaplan-Meier and Cox regression analyses. Subgroup survival outcomes were analyzed by first-line tr...
Source: Current Oncology - October 22, 2021 Category: Cancer & Oncology Authors: Rodrigo Rigo Jordan Doherty Kim Koczka Shiying Kong Philip Q Ding Tina Cheng Winson Y Cheung Jose G Monzon Source Type: research

Cognitive Assessment Tools Recommended in Geriatric Oncology Guidelines: A Rapid Review
Curr Oncol. 2021 Oct 8;28(5):3987-4003. doi: 10.3390/curroncol28050339.ABSTRACTCognitive assessment is a cornerstone of geriatric care. Cognitive impairment has the potential to significantly impact multiple phases of a person's cancer care experience. Accurately identifying this vulnerability is a challenge for many cancer care clinicians, thus the use of validated cognitive assessment tools are recommended. As international cancer guidelines for older adults recommend Geriatric Assessment (GA) which includes an evaluation of cognition, clinicians need to be familiar with the overall interpretation of the commonly used co...
Source: Current Oncology - October 22, 2021 Category: Cancer & Oncology Authors: Gina Tuch Wee Kheng Soo Ki-Yung Luo Kinglsey Frearson Ek Leone Oh Jane L Phillips Meera Agar Heather Lane Source Type: research

The Role of a Navigational Radiofrequency Ablation Device and Concurrent Vertebral Augmentation for Treatment of Difficult-to-Reach Spinal Metastases
Curr Oncol. 2021 Oct 8;28(5):4004-4015. doi: 10.3390/curroncol28050340.ABSTRACTAIMS: The purpose of this study was to assess the effectiveness of a navigational radiofrequency ablation device with concurrent vertebral augmentation in the treatment of posterior vertebral body metastatic lesions, which are technically difficult to access. Primary outcomes of the study were evaluation of pain palliation and radiologic assessment of local tumor control.MATERIALS AND METHODS: Thirty-five patients with 41 vertebral spinal metastases involving the posterior vertebral body underwent computed tomography-guided percutaneous targeted...
Source: Current Oncology - October 22, 2021 Category: Cancer & Oncology Authors: Claudio Pusceddu Davide De Francesco Luca Melis Nicola Ballicu Alessandro Fancellu Source Type: research

Multifocality and Multicentrality in Breast Cancer: Comparison of the Efficiency of Mammography, Contrast-Enhanced Spectral Mammography, and Magnetic Resonance Imaging in a Group of Patients with Primarily Operable Breast Cancer
CONCLUSIONS: In patients with MFMCC, both CESM and MRI are highly sensitive in the detection of additional cancer foci. Both CESM and MRI change the extent of surgical intervention in every fourth patient.PMID:34677259 | PMC:PMC8534697 | DOI:10.3390/curroncol28050341 (Source: Current Oncology)
Source: Current Oncology - October 22, 2021 Category: Cancer & Oncology Authors: Katarzyna Steinhof-Radwa ńska Andrzej Lorek Micha ł Holecki Anna Barczyk-Gutkowska Anna Gra żyńska Joanna Szczud ło-Chraścina Oskar Bo żek Justyna Habas Karol Szyluk Pawe ł Niemiec Iwona Gisterek Source Type: research

The Influence of Adjuvant Chemotherapy Dose Intensity on Five-Year Outcomes in Resected Colon Cancer: A Single Centre Retrospective Analysis
Curr Oncol. 2021 Oct 9;28(5):4031-4041. doi: 10.3390/curroncol28050342.ABSTRACTThere is evidence that achieving a dose intensity> 80% in adjuvant colon cancer treatment improves survival. In total, 192 consecutive patients with resected stage III and high-risk stage II colon cancer that received adjuvant chemotherapy were retrospectively analyzed. Patients who received at least 6 weeks of adjuvant therapy were included. The primary objective was to assess the influence of dose index (DI) and relative dose intensity (RDI) on DFS and OS at 3 and 5 years in patients receiving fluorouracil-based doublet therapy with oxalipl...
Source: Current Oncology - October 22, 2021 Category: Cancer & Oncology Authors: Suganija Lakkunarajah Daniel A Breadner Hanbo Zhang Ellen Yamanaka Andrew Warner Stephen Welch Source Type: research

Examining the Pathoplastic Moderating Role of Education on the Association between Depressive Mood and Self-Rated Health among Cancer Survivors: A Population-Based Study
CONCLUSION: Moving beyond the direct association between depressive mood, education, and SRH, education served as a pathoplastic moderator in relation to depressive mood and SRH. Psycho-oncology providers need to be mindful of the "protective-risk" effect of education in relation to cancer survivors' depressive mood and SRH.PMID:34677261 | PMC:PMC8534924 | DOI:10.3390/curroncol28050343 (Source: Current Oncology)
Source: Current Oncology - October 22, 2021 Category: Cancer & Oncology Authors: Anao Zhang Kaipeng Wang Adam S DuVall Source Type: research

Breast Cancer Surgery: New Issues
Curr Oncol. 2021 Oct 11;28(5):4053-4066. doi: 10.3390/curroncol28050344.ABSTRACTSince ancient times, breast cancer treatment has crucially relied on surgeons and clinicians making great efforts to find increasingly conservative approaches to cure the tumor. In the Halstedian era (mid-late 19th century), the predominant practice consisted of the radical and disfiguring removal of the breast, much to the detriment of women's psycho-physical well-being. Thanks to enlightened scientists such as Professor Umberto Veronesi, breast cancer surgery has since impressively progressed and adopted a much more conservative approach. Ove...
Source: Current Oncology - October 22, 2021 Category: Cancer & Oncology Authors: Francesca Magnoni Sofia Alessandrini Luca Alberti Andrea Polizzi Anna Rotili Paolo Veronesi Giovanni Corso Source Type: research

Recent Advances in Photodynamic Imaging and Therapy in Hepatobiliary Malignancies: Clinical and Experimental Aspects
Curr Oncol. 2021 Oct 11;28(5):4067-4079. doi: 10.3390/curroncol28050345.ABSTRACTThe therapeutic and diagnostic modalities of light are well known, and derivative photodynamic reactions with photosensitizers (PSs), specific wavelengths of light exposure and the existence of tissue oxygen have been developed since the 20th century. Photodynamic therapy (PDT) is an effective local treatment for cancer-specific laser ablation in malignancies of some organs, including the bile duct. Although curability for extrahepatic cholangiocarcinoma is expected with surgery alone, patients with unresectable or remnant biliary cancer need o...
Source: Current Oncology - October 22, 2021 Category: Cancer & Oncology Authors: Atsushi Nanashima Masahide Hiyoshi Naoya Imamura Koichi Yano Takeomi Hamada Kengo Kai Source Type: research

< em > Synaptotagmin 13 < /em > Is Highly Expressed in Estrogen Receptor-Positive Breast Cancer
CONCLUSION: This study suggests that SYT13 is highly expressed in ER-positive BC cells and clinical specimens, and there is a positive association of SYT13 with the ER signaling pathways.PMID:34677264 | PMC:PMC8535095 | DOI:10.3390/curroncol28050346 (Source: Current Oncology)
Source: Current Oncology - October 22, 2021 Category: Cancer & Oncology Authors: Takahiro Ichikawa Masahiro Shibata Takahiro Inaishi Ikumi Soeda Mitsuro Kanda Masamichi Hayashi Yuko Takano Dai Takeuchi Nobuyuki Tsunoda Yasuhiro Kodera Toyone Kikumori Source Type: research

Immunotherapy in Extensive-Stage Small Cell Lung Cancer
Curr Oncol. 2021 Oct 12;28(5):4093-4108. doi: 10.3390/curroncol28050347.ABSTRACTSmall cell lung cancer (SCLC) remains a poorly understood disease with aggressive features, high relapse rates, and significant morbidity as well as mortality, yet persistently limited treatment options. For three decades, the treatment algorithm of SCLC has been stagnant despite multiple attempts to find alternative therapeutic options that could improve responses and increase survival rates. On the other hand, immunotherapy has been a thriving concept that revolutionized treatment options in multiple malignancies, rendering previously untreat...
Source: Current Oncology - October 22, 2021 Category: Cancer & Oncology Authors: Rola El Sayed Normand Blais Source Type: research

Incidence, Etiology, Prevention and Management of Ureteroenteric Strictures after Robot-Assisted Radical Cystectomy: A Review of Published Evidence and Personal Experience
Curr Oncol. 2021 Oct 13;28(5):4109-4117. doi: 10.3390/curroncol28050348.ABSTRACTBenign ureteroenteric anastomosis strictures (UESs) are one of many critical complications that may cause irreversible disability following robot-assisted radical cystectomy (RARC). Previous studies have shown that the incidence rates of UES after RARC can reach 25.3%, with RARC having higher UES incidence rates compared to open radical cystectomy. Various known and unknown factors are involved in the occurrence of UES. To minimize the incidence of UES after RARC, our group has standardized the procedure and technique for intracorporeal urinary...
Source: Current Oncology - October 22, 2021 Category: Cancer & Oncology Authors: Shintaro Narita Mitsuru Saito Kazuyuki Numakura Tomonori Habuchi Source Type: research

Impact of Split Dosing the First Rituximab Infusion in Patients with High Lymphocyte Count
Curr Oncol. 2021 Oct 13;28(5):4118-4128. doi: 10.3390/curroncol28050349.ABSTRACTThe most common adverse reactions to rituximab are infusion-related reactions (IRR). We evaluated the efficacy of split dosing the first rituximab infusion over two days to reduce IRR incidence in patients with hematological cancer and a high lymphocyte count. This is a retrospective observational study conducted in two healthcare centers in Quebec, Canada. The study enrolled patients with white blood cell counts ≥25.0 × 109/L who received their first rituximab dose for hematological cancer between December 2007 and May 2020. One healt...
Source: Current Oncology - October 22, 2021 Category: Cancer & Oncology Authors: Maude Plante Laurence Garneau Magali Laprise-Lachance Pierre Lemieux Michel Dorval Source Type: research

Neoadjuvant Therapy in Lung Cancer: What Is Most Important: Objective Response Rate or Major Pathological Response?
Curr Oncol. 2021 Oct 13;28(5):4129-4138. doi: 10.3390/curroncol28050350.ABSTRACTLung cancer is the most fatal and frequently diagnosed malignant tumor. Neoadjuvant therapy is a promising approach for prolonging survival and increasing the chance of cure rates for patients with potentially resectable disease. Currently, many therapeutic alternatives, including chemotherapy, targeted therapy, and immunotherapy, are continually being explored to enrich the content of neoadjuvant therapy. However, neoadjuvant therapy remains to have no unified evaluation standards. Overall survival (OS) is the "gold standard" for eva...
Source: Current Oncology - October 22, 2021 Category: Cancer & Oncology Authors: Xi Chen Kewei Ma Source Type: research

Exercise to Reduce Anthracycline-Mediated Cardiovascular Complications in Breast Cancer Survivors
Curr Oncol. 2021 Oct 13;28(5):4139-4156. doi: 10.3390/curroncol28050351.ABSTRACTWhile developments in cancer therapeutics have greatly reduced morbidity and mortality in females with breast cancer, it comes at a cost of an increased risk of cardiovascular complications. In particular, anthracyclines, like doxorubicin, which are a mainstay of current chemotherapy regimens, are associated with dose-dependent cardiotoxicity. Exercise has been widely accepted as an effective intervention in reducing cardiovascular risk in a variety of different clinical conditions. However, the benefits of exercise in anthracycline-mediated ca...
Source: Current Oncology - October 22, 2021 Category: Cancer & Oncology Authors: Sonu S Varghese Will J Johnston Cameron R Eekhoudt Melanie R Keats Davinder S Jassal Scott A Grandy Source Type: research

Pretreatment Neutrophil-to-Lymphocyte Ratio as a Predictive Marker of Response to Atezolizumab Plus Bevacizumab for Hepatocellular Carcinoma
Curr Oncol. 2021 Oct 14;28(5):4157-4166. doi: 10.3390/curroncol28050352.ABSTRACTBACKGROUND: Combination therapy with anti-programmed death-ligand 1 monoclonal antibody atezolizumab plus anti-vascular endothelial growth factor agent bevacizumab (Atezo/Bev) was approved in 2020 as a first-line treatment for unresectable hepatocellular carcinoma (HCC). Atezo/Bev therapy is relatively well tolerated; however, factors that can predict its response have not yet been reported. Thus, we aimed to investigate whether the pretreatment neutrophil-to-lymphocyte ratio (NLR) could predict the therapeutic response in patients with HCC tre...
Source: Current Oncology - October 22, 2021 Category: Cancer & Oncology Authors: Yuji Eso Haruhiko Takeda Kojiro Taura Atsushi Takai Ken Takahashi Hiroshi Seno Source Type: research

Single-Center Comparison of [ < sup > 64 < /sup > Cu]-DOTAGA-PSMA and [ < sup > 18 < /sup > F]-PSMA PET-CT for Imaging Prostate Cancer
CONCLUSIONS: [64Cu]-DOTAGA-PSMA and [18F]-PSMA have comparable detection rates for the assessment of residual disease in patients with recurrent or primary progressive prostate cancer. The uptake in the liver is moderately different, and therefore at least the SUVs of the lesions in both studies would not be comparable.PMID:34677271 | PMC:PMC8534892 | DOI:10.3390/curroncol28050353 (Source: Current Oncology)
Source: Current Oncology - October 22, 2021 Category: Cancer & Oncology Authors: Siroos Mirzaei Rainer Lipp Shahin Zandieh Asha Leisser Source Type: research

Considerations for Developing a Reassessment Process: Report from the Canadian Real-World Evidence for Value of Cancer Drugs (CanREValue) Collaboration's Reassessment and Uptake Working Group
Curr Oncol. 2021 Oct 16;28(5):4174-4183. doi: 10.3390/curroncol28050354.ABSTRACTThe Canadian Real-world Evidence for Value in Cancer Drugs (CanREValue) Collaboration was established to develop a framework for generating and using real-world evidence (RWE) to inform the reassessment of cancer drugs following initial health technology assessment (HTA). The Reassessment and Uptake Working Group (RWG) is one of the five established CanREValue Working Groups. The RWG aims to develop considerations for incorporating RWE for HTA reassessment and strategies for using RWE to reassess drug funding decisions. Between February 2018 an...
Source: Current Oncology - October 22, 2021 Category: Cancer & Oncology Authors: Wei Fang Dai Vanessa Arciero Erica Craig Brent Fraser Jessica Arias Darryl Boehm Nevzeta Bosnic Patricia Caetano Carole Chambers Barry Jones Elena Lungu Gunita Mitera Tanya Potashnik Anthony Reiman Trevor Ritcher Jaclyn M Beca Avram Denburg Rebecca E Merc Source Type: research

At the Heart of It All: Emotions of Consequence for the Conceptualization of Caregiver-Reported Outcomes in the Context of Colorectal Cancer
Curr Oncol. 2021 Oct 16;28(5):4184-4202. doi: 10.3390/curroncol28050355.ABSTRACTColorectal cancer (CRC) can be demanding for primary caregivers; yet, there is insufficient evidence describing the caregiver-reported outcomes (CROs) that matter most to caregivers. CROs refer to caregivers' assessments of their own health status as a result of supporting a patient. The study purpose was to describe the emotions that were most impactful to caregivers of patients with CRC, and how the importance caregivers attribute to these emotions changed from diagnosis throughout treatment. Guided by qualitative Interpretive Description, we...
Source: Current Oncology - October 22, 2021 Category: Cancer & Oncology Authors: A Fuchsia Howard Kelsey Lynch Scott Beck Maria-Jos é Torrejón Jonathan Avery Sally Thorne Antony Porcino Mary De Vera Leah Lambert Angela Wolff Melanie McDonald Joyce Lee Penelope Hedges Michael McKenzie Source Type: research

Changes in Health State Utility Values in Japanese Patients with End-Stage Breast Cancer
Curr Oncol. 2021 Oct 18;28(5):4203-4212. doi: 10.3390/curroncol28050356.ABSTRACTWe aimed to determine the dynamic trends in health state utility values (HSUVs) in patients with end-stage breast cancer. We selected 181 patients comprising 137 with primary breast cancer (PBC) and 44 with metastatic breast cancer (MBC) (28 survivors and 16 patients with MBC death). HSUVs were 0.90 and 0.89 in patients with PBC and 0.83 and 0.80 in those with MBC (survivors) at 6 and 3 months, respectively, before the end of the observation period; these values were 0.73 and 0.66, respectively, in those with MBC (deceased) during the aforement...
Source: Current Oncology - October 22, 2021 Category: Cancer & Oncology Authors: Tsuguo Iwatani Shinichi Noto Koichiro Tsugawa Source Type: research

Effectiveness and Safety of First-Line Pembrolizumab in Older Adults with PD-L1 Positive Non-Small Cell Lung Cancer: A Retrospective Cohort Study of the Alberta Immunotherapy Database
In conclusion, age does not impact the efficacy or safety of pembrolizumab in NSCLC, and therefore advanced age should not be a deterrent for treating these patients with pembrolizumab. Physicians and care providers can thus focus on other factors that may influence therapeutic outcomes.PMID:34677275 | PMC:PMC8534423 | DOI:10.3390/curroncol28050357 (Source: Current Oncology)
Source: Current Oncology - October 22, 2021 Category: Cancer & Oncology Authors: Heidi A I Grosjean Samantha Dolter Daniel E Meyers Philip Q Ding Igor Stukalin Siddhartha Goutam Shiying Kong Quincy Chu Daniel Y C Heng D Gwyn Bebb Don G Morris Winson Y Cheung Aliyah Pabani Source Type: research

Total Colectomy as a Part of Ultra-Radical Surgery for Ovarian Cancer-Short- and Long-Term Outcomes
Conclusions: TC as a part of ultra-radical surgery for advanced OC results in high rates of optimal debulking. However, survival benefits were observed only in patients with no macroscopic disease.PMID:34677276 | PMC:PMC8534540 | DOI:10.3390/curroncol28050358 (Source: Current Oncology)
Source: Current Oncology - October 22, 2021 Category: Cancer & Oncology Authors: Sebastian Szubert Artur Skowyra Andrzej W ójtowicz Pawel Pawlowicz Marek Szczepkowski Blazej Nowakowski Lukasz Wicherek Source Type: research

Omental Macrophagic "Crown-like Structures" Are Associated with Poor Prognosis in Advanced-Stage Serous Ovarian Cancer
In conclusion, we, for the first time, demonstrate that the presence of omental CLSs is associated with poor prognosis in advanced-stage HGSOC.PMID:34677277 | PMC:PMC8534828 | DOI:10.3390/curroncol28050359 (Source: Current Oncology)
Source: Current Oncology - October 22, 2021 Category: Cancer & Oncology Authors: Yu-Ling Liang Chang-Ni Lin Hsing-Fen Tsai Pei-Ying Wu Sheng-Hsiang Lin Tse-Ming Hong Keng-Fu Hsu Source Type: research

Retrospective Cohort Study of Caveolin-1 Expression as Prognostic Factor in Unresectable Locally Advanced or Metastatic Pancreatic Cancer Patients
Curr Oncol. 2021 Sep 9;28(5):3525-3536. doi: 10.3390/curroncol28050303.ABSTRACTCaveolin-1 (Cav-1) plays a key role in various neoplastic diseases and is upregulated in different cancers, including pancreatic ductal adenocarcinoma (PDAC). Furthermore, Cav-1 is critical for the uptake of albumin as well as nab-paclitaxel in PDAC cells. Here, we investigated the prognostic impact of Cav-1 expression in a cohort of 39 metastatic PDAC patients treated with different first-line chemotherapy regimens. We also assessed the predictive value of Cav-1 in patients treated with gemcitabine and nab-paclitaxel. Cav-1 expression was evalu...
Source: Current Oncology - September 30, 2021 Category: Cancer & Oncology Authors: Alessandro Bittoni Riccardo Giampieri Federica Pecci Giada Pinterpe Alessandra Mandolesi Michela Del Prete Antonio Zizzi Sonia Crocetti Carolina Liguori Giulia Mentrasti Luca Cantini Chiara Pellei Renato Bisonni Marina Scarpelli Rossana Berardi Source Type: research

Differential Expression of Non-Coding RNA Signatures in Thyroid Cancer between Two Ethnic Groups
Curr Oncol. 2021 Sep 19;28(5):3610-3628. doi: 10.3390/curroncol28050309.ABSTRACTFilipino Americans show higher thyroid cancer recurrence rates compared to European Americans. Although they are likely to die of this malignancy, the molecular mechanism has not yet been determined. Recent studies demonstrated that small non-coding RNAs could be utilized to assess thyroid cancer prognosis in tumor models. The goal of this study is to determine whether microRNA (miRNA) signatures are differentially expressed in thyroid cancer in two different ethnic groups. We also determined whether these miRNA signatures are related to cancer...
Source: Current Oncology - September 30, 2021 Category: Cancer & Oncology Authors: Kristiana Rood Khodeza Begum Hanmin Wang Yan C Wangworawat Ryan Davis Celina R Yamauchi Mia C Perez Alfred A Simental Ria T Laxa Charles Wang Sourav Roy Salma Khan Source Type: research

Hypofractionated Stereotactic Radiotherapy for the Treatment of Benign Intracranial Meningiomas: Long-Term Safety and Efficacy
CONCLUSIONS: Based on our data, hSRT remains an effective modality to treat low-grade ICMs with acceptable long-term toxicity and radionecrosis rates. hSRT should be offered to patients who are not ideal candidates for SRS while preserving the benefits of hypofractionation.PMID:34590613 | PMC:PMC8482200 | DOI:10.3390/curroncol28050314 (Source: Current Oncology)
Source: Current Oncology - September 30, 2021 Category: Cancer & Oncology Authors: Eric K Nguyen Gregory R Pond Jeffrey N Greenspoon Anthony C Whitton Crystal Hann Source Type: research

Detection of Cervical Cancer Cells in Whole Slide Images Using Deformable and Global Context Aware Faster RCNN-FPN
In this study, we proposed a novel framework based on Faster RCNN-FPN architecture for the detection of abnormal cervical cells in cytology images from a cancer screening test. We extended the Faster RCNN-FPN model by infusing deformable convolution layers into the feature pyramid network (FPN) to improve scalability. Furthermore, we introduced a global contextual aware module alongside the Region Proposal Network (RPN) to enhance the spatial correlation between the background and the foreground. Extensive experimentations with the proposed deformable and global context aware (DGCA) RCNN were carried out using the cervical...
Source: Current Oncology - September 30, 2021 Category: Cancer & Oncology Authors: Xia Li Zhenhao Xu Xi Shen Yongxia Zhou Binggang Xiao Tie-Qiang Li Source Type: research

Prospective Monitoring of Circulating Epithelial Tumor Cells (CETC) Reveals Changes in Gene Expression during Adjuvant Radiotherapy of Breast Cancer Patients
Curr Oncol. 2021 Sep 8;28(5):3507-3524. doi: 10.3390/curroncol28050302.ABSTRACTCirculating epithelial tumor cells (CETC) are considered to be responsible for the formation of metastases. Therefore, their importance as prognostic and/or predictive markers in breast cancer is being intensively investigated. Here, the reliability of single cell expression analyses in isolated and collected CETC from whole blood samples of patients with early-stage breast cancer before and after radiotherapy (RT) using the maintrac® method was investigated. Single-cell expression analyses were performed with qRT-PCR on a panel of selected ...
Source: Current Oncology - September 30, 2021 Category: Cancer & Oncology Authors: Matthias M äurer Katharina Pachmann Thomas Wendt Dorothea Schott Andrea Wittig Source Type: research

The Past, Present, and Future of Economic Evaluations of Precision Medicine at the Committee for Economic Analyses of the Canadian Cancer Trials Group
Curr Oncol. 2021 Sep 21;28(5):3649-3658. doi: 10.3390/curroncol28050311.ABSTRACTPrecision medicine in oncology poses unique challenges to the generation of clinical and economic evidence used for cost-effectiveness analyses that can inform health technology assessment. The conduct of randomized controlled trials for biomarker-specific therapies targeted towards small populations has limitations in regard to feasibility, timeliness, and cost. These limitations result in associated challenges for groups involved in the generation of economic evidence to inform treatment-related decision making, including the Committee of Eco...
Source: Current Oncology - September 30, 2021 Category: Cancer & Oncology Authors: Kelvin K W Chan Matthew C Cheung Dean A Regier Annette Hay Alexander V Louie Winson Y Cheung Jean-Eric Tarride Suji Udayakumar Nicole Mittmann Source Type: research

Distal Fibula Reconstruction in Primary Malignant Tumours
Conclusions: After DF resection, the restoration of ankle biomechanics gives acceptable functional results, but a larger series of patients with long-time follow-up are required to confirm the durability of the reconstruction.PMID:34590617 | PMC:PMC8482106 | DOI:10.3390/curroncol28050299 (Source: Current Oncology)
Source: Current Oncology - September 30, 2021 Category: Cancer & Oncology Authors: Adyb Adrian Khal Riccardo Zucchini Claudio Giannini Andrea Sambri Davide Maria Donati Massimiliano De Paolis Source Type: research