Injectable antibody drug protects children from malaria in Mali trial
A single dose of an experimental antibody drug protects children from malaria for up to 6 months, according to a clinical study published today in
The New England Journal of Medicine
.
The therapy, an injectable monoclonal antibody called L9LS that has
already shown success in adults
, reduced infections and clinical disease in 6- to 10-year-olds in Mali. Although the drug is still undergoing clinical testing, the results suggest monoclonal antibodies could be an important addition to the arsenal against this deadly disease, researchers say.
Malaria caused an estimated 608,000 deaths in 2022...
Source: ScienceNOW - April 26, 2024 Category: Science Source Type: news
Development and validation of Malaysian one stop crisis center service quality instrument (OSCC-Qual) for domestic violence management - Chew KS, Wong SSL, Siew KL, Kandasamy V.
One Stop Crisis Center (OSCC) is a multi-sectorial center aimed to provide medical, social, legal, police and shelter services to survivors of domestic violence, rape, sexual assault, sodomy and child abuse. Although OSCCs have been established for almost ... (Source: SafetyLit)
Source: SafetyLit - April 26, 2024 Category: International Medicine & Public Health Tags: Jurisprudence, Laws, Legislation, Policies, Rules Source Type: news
Validation of the Dominican system for measuring early childhood development - S ánchez-Vincitore LV, Alonso Pellerano MA, Valdez ME, Jiménez AS, Ruiz-Matuk CB, Castro A, Díaz F, Cubilla-Bonnetier D.
BACKGROUND: The purpose of the study was to determine the psychometric properties of the Dominican System for Measuring Early Childhood Development (SIMEDID, for its Spanish acronym), to adjust the sequence of item presentation, and to provide age-standard... (Source: SafetyLit)
Source: SafetyLit - April 26, 2024 Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
The clinical picture of bipolar affective disorders in children and adolescents hospitalized at the psychiatric ward in Sosnowiec - Cicho ń L, Janas-Kozik M, Chełmecka E, Wilczyński KM, Jelonek I, Rybakowski JK.
OBJECTIVES: To determine the clinical picture of bipolar affective disorders (BD) in children and adolescents hospitalized at the Clinical Ward of Developmental Age Psychiatry and Psychotherapy (DAPP) in Sosnowiec, Poland. METHODS: Documentation an... (Source: SafetyLit)
Source: SafetyLit - April 26, 2024 Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
Where do elbows and knees come from? Biologists track them back to our boneless, sharklike ancestors
Ask an older person where painful arthritis strikes and most will point to their joints—knees, hips, and fingers. That’s because as people age, those joints lose the cartilage and viscous fluid, known as synovial fluid, that keeps them supple. Sharks and skates have no bones—and no arthritis—but they apparently have the same kind of joints we do. Once thought to exist only in bony vertebrates, these so-called
synovial joints actually evolved in the much older ancestor of cartilaginous and bony fish
, researchers reported earlier this month in a preprint on bioRxiv.
“They very convincingly show tha...
Source: ScienceNOW - April 25, 2024 Category: Science Source Type: news
Exploring the nexus of adverse childhood experiences and aggression in children and adolescents: a scoping review - Stoppelbein L, McRae E, Smith S.
A strong relation between adverse childhood experiences (ACE) and aggression has been established in adult populations, with less research examining this relation earlier in development. The purpose of this study was to complete a scoping review of the cur... (Source: SafetyLit)
Source: SafetyLit - April 25, 2024 Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
Opioids During Pregnancy May Not Raise Psychiatric Risks for Offspring
THURSDAY, April 24, 2024 -- Prescription opioids taken during pregnancy are not associated with a substantial increase in risk of developmental disorders like ADHD in children, a new study has found.“A slightly increased risk of... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - April 25, 2024 Category: General Medicine Source Type: news
Insights into child abuse and neglect: findings from the Minnesota Longitudinal Study of Risk and Adaptation - Nivison MD, Labella MH, Raby KL, Doom JR, Martin J, Johnson WF, Zamir O, Englund MM, Simpson JA, Carlson EA, Roisman GI.
The Minnesota Longitudinal Study of Risk and Adaptation (MLSRA) is a landmark prospective, longitudinal study of human development focused on a sample of mothers experiencing poverty and their firstborn children. Although the MLSRA pioneered a number of im... (Source: SafetyLit)
Source: SafetyLit - April 24, 2024 Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
The effect of peers' theory of mind on children's own theory of mind development: a longitudinal study in middle childhood and early adolescence - Lecce S, Ronchi L, Devine RT.
While there is considerable evidence that children's early ability to understand others' mental states, called "theory of mind," is shaped by family experiences, it remains unclear whether children's social interactions at school influence theory of mind (... (Source: SafetyLit)
Source: SafetyLit - April 24, 2024 Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
Can behaviorally inhibited preschoolers make friends? - Fleece H, Wagner NJ, Chronis-Tuscano A, Smith KA, Novick DR, Druskin LR, Shakiba N, Danko CM, Rubin KH.
Preschoolers who display extremely inhibited behavior are at risk for the development of anxiety disorders. However, behavioral inhibition (BI) is a multifaceted characteristic. Some children with BI are fearful when confronted by unfamiliar adults, peers,... (Source: SafetyLit)
Source: SafetyLit - April 24, 2024 Category: International Medicine & Public Health Tags: Age: Infants and Children Source Type: news
[Ad hoc announcement pursuant to Art. 53 LR] Roche sales increase by 2% (CER) in first quarter with both divisions growing in high single digit ex COVID-19
Group sales grew by 2%1 at constant exchange rates (CER) (-6% in CHF), driven by the strong growth of newer medicines and diagnostics. Excluding COVID-19-related products, sales increased by 7%. Going forward, there will be no further material impact of COVID-19 sales declineDue to the appreciation of the Swiss franc against most currencies,saleswere 6% lower when reported in CHFPharmaceuticals Divisionbase business2 grew by 7%, driven by strong sales of medicines to treat severe diseases, such as Vabysmo (eye diseases), Phesgo (breast cancer), Ocrevus (multiple sclerosis), Polivy (blood cancer) and Hemlibra (haemophilia A...
Source: Roche Investor Update - April 24, 2024 Category: Pharmaceuticals Source Type: news
[Ad hoc announcement pursuant to Art. 53 LR] Roche sales increase by 2% (CER) in first quarter with both divisions growing in high single digit ex COVID-19
Group sales grew by 2%1 at constant exchange rates (CER) (-6% in CHF), driven by the strong growth of newer medicines and diagnostics. Excluding COVID-19-related products, sales increased by 7%. Going forward, there will be no further material impact of COVID-19 sales declineDue to the appreciation of the Swiss franc against most currencies,saleswere 6% lower when reported in CHFPharmaceuticals Divisionbase business2 grew by 7%, driven by strong sales of medicines to treat severe diseases, such as Vabysmo (eye diseases), Phesgo (breast cancer), Ocrevus (multiple sclerosis), Polivy (blood cancer) and Hemlibra (haemophilia A...
Source: Roche Media News - April 24, 2024 Category: Pharmaceuticals Source Type: news
Researchers publish final results of key clinical trial for gene therapy for sickle cell disease
In a landmark study, an international consortium led by researchers at Children's Hospital of Philadelphia (CHOP) published the final results of a key clinical trial of the gene therapy CASGEVY (exagamglogene autotemcel) for the treatment of sickle cell disease in patients 12 years and older with recurrent vaso-occlusive crises (VOCs). The study found that 96.7% of patients in the study did not have any vaso-occlusive crises (VOCs) - a blockage that results in lack of oxygen and painful episodes - for at least one year, and 100% were able to remain hospitalization-free for the same length of time. (Source: World Pharma News)
Source: World Pharma News - April 24, 2024 Category: Pharmaceuticals Tags: Featured Research Research and Development Source Type: news
‘Kinder’ treatment for childhood brain cancer to be offered by NHS in England
Dabrafenib with trametinib can halt growth of some tumours for more than three times as long as standard chemotherapy, study showsThe NHS is to offer children with brain tumours in England a groundbreaking new targeted drug therapy to tackle the disease – a development charities are hailing as the biggest breakthrough in decades.Gliomas are the most common type of brain cancer in children but experts say the standard treatment of chemotherapy can be brutal and gruelling, and also carries the risk of side-effects such as weight loss, seizures and headaches.Continue reading... (Source: Guardian Unlimited Science)
Source: Guardian Unlimited Science - April 24, 2024 Category: Science Authors: Andrew Gregory Health editor Tags: Cancer Children's health National Institute for Health and Care Excellence England NHS UK news Society Medical research Science Source Type: news
Autism symptoms in children: Early signs and when they start showing
Autism spectrum disorder is a developmental disorder that affects communication and behaviour. Here are some of the early signs of autism in children. (Source: Daily Express - Health)
Source: Daily Express - Health - April 24, 2024 Category: Consumer Health News Source Type: news
