Cystic fibrosis boy, 8, urges firm to lower Orkambi drug price
Luis Walker, 8, wrote to Vertex Pharmaceuticals saying Orkambi would make him "feel much better". (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - August 15, 2018 Category: Consumer Health News Source Type: news

VIDEO – Taking on Cystic Fibrosis: A Student Story
Dartmouth College undergraduate Sam Neff D '21 fights cystic fibrosis (CF) every day by following a strict treatment regimen, by contributing to CF research in Geisel’s Lung Biology Center, and by participating in a clinical trial at Dartmouth-Hitchcock. (Source: News at Dartmouth Medical School)
Source: News at Dartmouth Medical School - August 14, 2018 Category: Hospital Management Authors: Jennifer Durgin Tags: Multimedia News Research Video cystic fibrosis Dartmouth undergraduate Home-feature Interaction student research Source Type: news

NICE, Vertex continue to spar over drug prices
The U.K.'s National Institute for Health and Care Excellence (NICE) has suspended its review of Vertex's Symkevi for treating cystic fibrosis patients who are homozygous for the F508del mutation, after the biotech did not provide evidence for the agency's appraisal. (Source: PharmaManufacturing.com)
Source: PharmaManufacturing.com - August 13, 2018 Category: Pharmaceuticals Source Type: news

Ambitious 'Human Cell Atlas' Aims To Catalog Every Type Of Cell In The Body
Already the project has revealed a previously unknown type of cell in the windpipe that might play a role in cystic fibrosis — and lead to a new treatment, scientists say.(Image credit: Casey Atkins/Broad Institute) (Source: NPR Health and Science)
Source: NPR Health and Science - August 13, 2018 Category: Consumer Health News Authors: Karen Weintraub Source Type: news

Research shows that cystic fibrosis impacts growth in the womb
(University of Liverpool) New research, published in Thorax, funded by the Cystic Fibrosis Trust has shown that babies with cystic fibrosis (CF) are born weighing less than babies without the condition, even allowing that they are more likely to be born prematurely. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - August 13, 2018 Category: International Medicine & Public Health Source Type: news

Finally, a potential new approach against KRAS-driven lung cancer
(University of Colorado Anschutz Medical Campus) University of Colorado Cancer Center and M.D. Anderson Cancer Center study shows KRAS-driven lung cancers are also marked by high levels of 'gel-forming mucins,' as seen in some forms of asthma, chronic obstructive pulmonary disease and cystic fibrosis. The study, published Aug. 9 in the journal JCI Insight, also pinpoints a cause of increased mucin production, namely the gene MUC5AC. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - August 9, 2018 Category: Cancer & Oncology Source Type: news

Boehringer Ingelheim, the UK Cystic Fibrosis Gene Therapy Consortium, Imperial Innovations and Oxford BioMedica announce new partnership to develop first-in-class gene therapy for cystic fibrosis
Boehringer Ingelheim, the UK Cystic Fibrosis Gene Therapy Consortium (GTC) - consisting of Imperial College London and the Universities of Oxford and Edinburgh - Imperial Innovations, and Oxford BioMedica (OXB) announce a global collaboration to develop a first-in-class, long-term therapy for patients with cystic fibrosis (CF). (Source: World Pharma News)
Source: World Pharma News - August 7, 2018 Category: Pharmaceuticals Tags: Featured Boehringer Ingelheim Business and Industry Source Type: news

New Partnership to Develop Gene Therapy for Cystic Fibrosis
(Source: Boehringer Ingelheim Corporate News)
Source: Boehringer Ingelheim Corporate News - August 6, 2018 Category: Research Source Type: news

Celtaxsys Cystic Fibrosis Drug Reduces Key Symptom in Mid-Stage Study Celtaxsys Cystic Fibrosis Drug Reduces Key Symptom in Mid-Stage Study
Privately held Celtaxsys Inc said on Thursday a mid-stage trial testing its experimental cystic fibrosis treatment was successful in reducing a key symptom of the genetic lung disease, but did not improve lung function.Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - August 3, 2018 Category: Consumer Health News Tags: Pulmonary Medicine News Source Type: news

Research shows that cystic fibrosis impacts growth in the womb
(University of Liverpool) New research, published in Thorax, funded by the Cystic Fibrosis Trust has shown that babies with cystic fibrosis (CF) are born weighing less than babies without the condition, even allowing that they are more likely to be born prematurely. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - August 3, 2018 Category: International Medicine & Public Health Source Type: news

Celtaxsys cystic fibrosis drug reduces key symptom in mid-stage study
Privately held Celtaxsys Inc said on Thursday a mid-stage trial testing its experimental cystic fibrosis treatment was successful in reducing a key symptom of the genetic lung disease, but did not improve lung function. (Source: Reuters: Health)
Source: Reuters: Health - August 2, 2018 Category: Consumer Health News Tags: healthNews Source Type: news

New lung cell type discovered
(Harvard Medical School) In separate studies published online in Nature on Aug. 1, two independent research teams report the discovery of a new, rare type of cell in the human airway. These cells appear to be the primary source of activity of the CFTR gene, mutations to which cause cystic fibrosis, a multiorgan disease that affects more than 70,000 people worldwide. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - August 2, 2018 Category: International Medicine & Public Health Source Type: news

New Lung Cell Identified
The cell type was discovered via single-cell RNA sequencing of thousands of cells in mouse and human airways and may play a role in cystic fibrosis. (Source: The Scientist)
Source: The Scientist - August 1, 2018 Category: Science Tags: News & Opinion Source Type: news

EMA Panel Backs Tezacaftor, Ivacaftor Combo for CF EMA Panel Backs Tezacaftor, Ivacaftor Combo for CF
The Committee for Medicinal Products for Human Use of the European Medicines Agency recommended Symkevi for patients aged 12 years and older with cystic fibrosis (CF).International Approvals (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - July 30, 2018 Category: Consumer Health News Tags: Pulmonary Medicine News Alert Source Type: news

What Causes School Failure?
Discussion “Literacy is traditionally meant as the ability to read and write. The modern term’s meaning has been expanded to include the ability to use language, numbers, images, computers, and other basic means to understand, communicate, gain useful knowledge, solve mathematical problems and use the dominant symbol systems of a culture.” The earliest written communication was in 3500-3000 BCE, with the earliest alphabet being from 1200-750 BCE. Although the percentage of the world’s adult literacy rate is increasing each decade by ~5%, “…from 55.7 per cent in 1950 to 86.2 per cent in...
Source: PediatricEducation.org - July 30, 2018 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Toronto stands out for excellence in cystic fibrosis care in North America
(Source: St. Michael's Hospital News and Media)
Source: St. Michael's Hospital News and Media - July 27, 2018 Category: Hospital Management Tags: Hospital News Source Type: news

Recent Advances in Allergic Bronchopulmonary Aspergillosis Complicating Cystic Fibrosis
Wednesday, July 18, 2018 - 13:02Slide presentation (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - July 18, 2018 Category: Respiratory Medicine Authors: BethBradshaw Source Type: news

Bullying and mental health amongst Australian children and young people with cystic fibrosis - Branch-Smith C, Shaw T, Lin A, Runions K, Payne D, Nguyen R, Hugo H, Balding L, Cross D.
Currently, there is little research investigating how schools can support the mental health and social development of young people with cystic fibrosis (CF), given their heightened risk of mental illness. Few studies have examined the relationship between ... (Source: SafetyLit)
Source: SafetyLit - July 17, 2018 Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news

Technique may improve lung delivery of bacteria-killing phage
(Georgia Institute of Technology) A new delivery system for bacteriophages--viruses that selectively attack harmful bacteria--could help give doctors a new way to battle lung infections that threaten older patients and people with cystic fibrosis. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - July 16, 2018 Category: Infectious Diseases Source Type: news

Bronchiectasis (non-cystic fibrosis), acute exacerbation: antimicrobial prescribing
This draft guidance sets out an antimicrobial prescribing strategy for managing and preventing an acute exacerbation of bronchiectasis (non-cystic fibrosis). It aims to optimise antibiotic use and reduce antibiotic resistance. A 3-page visual summary of the recommendations is included. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - July 12, 2018 Category: Consumer Health News Source Type: news

Cystic Fibrosis
Title: Cystic FibrosisCategory: Diseases and ConditionsCreated: 12/31/1997 12:00:00 AMLast Editorial Review: 7/6/2018 12:00:00 AM (Source: MedicineNet Lungs General)
Source: MedicineNet Lungs General - July 6, 2018 Category: Respiratory Medicine Source Type: news

Postdoctoral Fellow: Comparative genomics and metagenomic approaches in patients with cystic fibrosis colonized with Aspergillus fumigatus and treated with triazoles.
(Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - July 5, 2018 Category: Respiratory Medicine Authors: GAtherton Source Type: news

Cancer cure could be found in space with plants grown in zero gravity
The key to beating cancer could be growing plants in space, suggests new research. Plants have been found to release different chemicals when cultivated in zero gravity, offering hope of finding cures for a host of diseases - from Alzheimer's to cystic fibrosis. (Source: Daily Express - Health)
Source: Daily Express - Health - July 4, 2018 Category: Consumer Health News Source Type: news

Supplemental antioxidants may reduce exacerbations in cystic fibrosis
(American Thoracic Society) An antioxidant-enriched vitamin may decrease respiratory exacerbations in people with cystic fibrosis (CF), according to new research published online in April in the American Journal of Respiratory and Critical Care Medicine. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - July 2, 2018 Category: International Medicine & Public Health Source Type: news

Some existing anti-cancer drugs may act in part by targeting RNA
Bolstering the notion that RNA should be considered an important drug-discovery target, scientists at Scripps Research have found that several existing, FDA-approved anti-cancer drugs may work, in part, by binding tightly to RNA, the regulators of the basic activities of life within cells. The research offers another approach for tackling diseases that have been considered "undruggable," including amyotrophic lateral sclerosis (ALS), muscular dystrophy, cystic fibrosis and certain cancers. (Source: World Pharma News)
Source: World Pharma News - June 29, 2018 Category: Pharmaceuticals Tags: Featured Research Research and Development Source Type: news

Buffalo General grows adult cystic fibrosis unit
Life expectancy has expanded from 10 years old to the mid-40s for individuals living with cystic fibrosis. That means greater patient volume at Kaleida's adult care hospital. (Source: bizjournals.com Health Care:Physician Practices headlines)
Source: bizjournals.com Health Care:Physician Practices headlines - June 29, 2018 Category: American Health Authors: Tracey Drury Source Type: news

Some existing anti-cancer drugs may act in part by targeting RNA, study shows
(Scripps Research Institute) The research offers another approach for tackling diseases that have been considered 'undruggable,' including amyotrophic lateral sclerosis (ALS), muscular dystrophy, cystic fibrosis and certain cancers. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 28, 2018 Category: International Medicine & Public Health Source Type: news

Children's Hospital Colorado joins cystic fibrosis triple combination therapy trials
(Children's Hospital Colorado) Children's Hospital Colorado has announced that its Mike McMorris Cystic Fibrosis Research and Care Center, one of the largest cystic fibrosis clinical care centers in the U.S., is participating in one of two Phase Three clinical trials related to the development of a possible breakthrough therapy for people with CF. Phase Three trials are generally the last round of trials before possible FDA approval of a new drug. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 28, 2018 Category: International Medicine & Public Health Source Type: news

Azithromycin Cuts Pulmonary Exacerbation in CF With Early Pa
WEDNESDAY, June 27, 2018 -- For children with cystic fibrosis (CF) and early Pseudomonas aeruginosa (Pa) infection, the risk of pulmonary exacerbation is significantly reduced with the addition of azithromycin to tobramycin inhalation solution... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - June 27, 2018 Category: Pharmaceuticals Source Type: news

MDI Biological Laboratory receives $70,000 to support organoid course
(Mount Desert Island Biological Laboratory) The MDI Biological Laboratory has announced that it received more than $70,000 in cash and in-kind awards for its inaugural " Applications of Organoid Technology " course, held May 27 through June 2 on the institution's Bar Harbor, Maine, campus. The awards included contributions from Baker, Corning, the Cystic Fibrosis Foundation, Nikon, Leica, Novartis Pharmaceuticals Corp., STEMCELL Technologies, Fisher Scientific and ThermoFisher Scientific. The week-long course was among the first to provide extensive hands-on training in organoid culture. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - June 26, 2018 Category: Cancer & Oncology Source Type: news

A Drug Costs $272,000 a Year. Not So Fast, Says New York State.
New York ’ s Medicaid program says Orkambi, a new drug to treat cystic fibrosis, is not worth the price. The case is being closely watched around the country. (Source: NYT Health)
Source: NYT Health - June 24, 2018 Category: Consumer Health News Authors: KATIE THOMAS Tags: Drugs (Pharmaceuticals) Health Insurance and Managed Care Cystic Fibrosis Prices (Fares, Fees and Rates) Medicaid Institute for Clinical and Economic Review orkambi Source Type: news

Improved treatment targeting root cause of cystic fibrosis may be on horizon
A clinical trial led by a pharmaceutical company with additional support from an NIDDK-supported Cystic Fibrosis Center has shown that a combination of two medications provides significant clinical benefit in a subgroup of patients with cystic fibrosis (CF). (Source: NIDDK News)
Source: NIDDK News - June 23, 2018 Category: Endocrinology Source Type: news

Protein-folding Chaperones Have Both Positive and Negative Roles To Play in Cystic Fibrosis
Proteins involved in ensuring that other proteins are in their proper shapes may have a role to play in mitigating the effects of cystic fibrosis. (Source: NIDDK News)
Source: NIDDK News - June 23, 2018 Category: Endocrinology Source Type: news

Irish cystic fibrosis patient begs UK health officials to approve his 'wonder drug'
EXCLUSIVE: Benat Broderick, from Dublin, argued his life has been transformed since he was given Orkambi. But UK watchdogs have denied patients access to the £100,000 medication. (Source: the Mail online | Health)
Source: the Mail online | Health - June 22, 2018 Category: Consumer Health News Source Type: news

Scientists Are Using a New Weapon to Fight Drug-Resistant Bacteria —Viruses
A new medical research center in San Diego is embracing an innovative way to treat antibiotic resistant infections called bacteriophage therapy—phage therapy for short—which uses viruses as weapons against hard-to-treat infections. Antibiotic-resistant infections are part of a growing global health problem. Each year in the United States, at least two million people contract drug-resistant infections, and 23,000 die from those illnesses. Bacteria naturally grow resistant to the drugs used to treat them, and for people with especially tough infections that aren’t responding to the usual medications, the op...
Source: TIME: Health - June 21, 2018 Category: Consumer Health News Authors: Alexandra Sifferlin Tags: Uncategorized healthytime medicine Source Type: news

Warren Alpert Foundation honors pioneering discoveries in cystic fibrosis
(Harvard Medical School) The 2018 Warren Alpert Foundation Prize has been awarded to five scientists for transformative discoveries in the fields of genetics, physiology, pulmonology and pharmacology that have led to the development of life-altering precision-targeted treatments for the devastating multiorgan disease cystic fibrosis (CF). (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 21, 2018 Category: International Medicine & Public Health Source Type: news

Doctors Think a Woman ’s Tattoo May Have Been Causing Her Severe Leg Pain
Doctors in Scotland believe a woman’s large tattoo on her leg may have been the cause of her unexplained inflammation and severe leg pain. The authors of a report on the woman’s case, published in BMJ Case Reports, say it is a reminder to physicians that they should be mindful of their patients’ tattoos if they encounter unusual and unexplained symptoms. The 31-year-old woman was suffering a condition called inflammatory myopathy, which affected her left leg and caused pain severe enough to disrupt her sleep. The woman had a double lung transplant in 2009, and was taking drugs to suppress her immune syst...
Source: TIME: Health - June 19, 2018 Category: Consumer Health News Authors: Alice Park Tags: Uncategorized healthytime onetime tattoos Source Type: news

New approach to advance drug pipeline for cystic fibrosis
For patients with rare genetic mutations of the debilitating disease cystic fibrosis, there are few options for effective treatment. EU-funded researchers are working to meet their needs, using new developments in personalised medicine to advance the testing of novel and promising drugs. (Source: EUROPA - Research Information Centre)
Source: EUROPA - Research Information Centre - June 19, 2018 Category: Research Source Type: news

Cystic fibrosis patient left in chronic pain after getting a TATTOO
The unnamed woman, from Scotland, had a large coloured ink tattoo on her left thigh in 2015 - but developed chronic pain within months. Doctors published the case in the BMJ Case Reports. (Source: the Mail online | Health)
Source: the Mail online | Health - June 18, 2018 Category: Consumer Health News Source Type: news

Tattoo health warning for people with weakened immune systems
A woman with cystic fibrosis and lung transplants suffered chronic pain for three years after she had a tattoo on her thighGetting a tattoo if you have a weakened immune system could put you at risk of complications, doctors have warned. The caution comes after a woman with cystic fibrosis and lung transplants developed thigh and knee pain after having body art inked on her leg.Doctors say those taking immunosuppressant drugs should take precautions if considering body art. These medicines are often given after an organ transplant or to treat autoimmune conditions such as Crohn ’s disease, lupus or rheumatoid arthrit...
Source: Guardian Unlimited Science - June 18, 2018 Category: Science Authors: Nicola Davis Tags: Tattoos Medical research Immunology Biochemistry and molecular biology Health Cystic fibrosis Diabetes Source Type: news

Sharing Mayo Clinic: New lungs give dad a chance to enjoy fatherhood
Over time, cystic fibrosis robbed Nicholas Hemmerle of his ability to enjoy active time with his daughter. But after a double lung transplant, he's breathing easier and ready to have fun again.? The last thing Nicholas Hemmerle remembers before going into surgery at?Mayo Clinic?for a double?lung transplant?is a nurse putting a blanket on him and [...] (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - June 17, 2018 Category: Databases & Libraries Source Type: news

I’ll do anything to save my little girl
THOUSANDS of patients are facing an agonising wait for a miracle drug that can stop the killer disease cystic fibrosis in its tracks. One mum tells LAURA MILNE her family ’s heartbreaking story. (Source: Daily Express - Health)
Source: Daily Express - Health - June 12, 2018 Category: Consumer Health News Source Type: news

Inhaled anti-pseudomonal antibiotics for long-term therapy in cystic fibrosis
This review of 18 RCTs (n=3,042) found that inhaled anti-pseudomonal antibiotic treatment probably improves lung function and reduces exacerbation rate, but pooled estimates of the level of benefit were very limited. The best evidence is for inhaled tobramycin (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 8, 2018 Category: Consumer Health News Source Type: news

ICER issues final report on CFTR modulators for cystic fibrosis
(Source: PharmacoEconomics and Outcomes News)
Source: PharmacoEconomics and Outcomes News - June 1, 2018 Category: Drugs & Pharmacology Source Type: news

Serum (1-3)-beta-D-Glucan and Galactomannan Levels in CF Serum (1-3)-beta-D-Glucan and Galactomannan Levels in CF
Find out about the role of beta-D-glucan and galactomannan levels in detecting fungal disease and assessing lung function in cystic fibrosis patients.BMC Pulmonary Medicine (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - May 30, 2018 Category: Consumer Health News Tags: Pulmonary Medicine Journal Article Source Type: news

Study finds antioxidant-enriched vitamin reduces respiratory illnesses in patients with CF
Researchers at Children's Hospital Colorado (Children's Colorado) and the University of Colorado School of Medicine have found that taking a specially formulated antioxidant-enriched multivitamin may decrease respiratory illnesses in people with cystic fibrosis (CF). The study, which was recently published online in the American Journal of Respiratory and Critical Care Medicine, looked at the effects of a 'cocktail' of multiple antioxidants on inflammation and health outcomes in patients with CF. (Source: World Pharma News)
Source: World Pharma News - May 24, 2018 Category: Pharmaceuticals Tags: Featured Research Research and Development Source Type: news

Her search for new lungs begins with changed heart
Claire Wineland vowed she wouldn't have a lung transplant, but her decline from cystic fibrosis made her reconsider. Now she's fighting for a chance at survival. (Source: CNN.com - Health)
Source: CNN.com - Health - May 23, 2018 Category: Consumer Health News Source Type: news

Study finds antioxidant-enriched vitamin reduces respiratory illnesses in patients with CF
(Children's Hospital Colorado) Researchers at Children's Hospital Colorado and the University of Colorado School of Medicine have found that taking a specially formulated antioxidant-enriched multivitamin may decrease respiratory illnesses in people with cystic fibrosis. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 23, 2018 Category: International Medicine & Public Health Source Type: news

AACR Ventures into New Cancer Research Funding Model
(MedPage Today) -- Adapting model pioneered by Cystic Fibrosis Foundation (Source: MedPage Today Public Health)
Source: MedPage Today Public Health - May 22, 2018 Category: American Health Source Type: news

Antibacterial in your toothpaste may combat severe lung disease
(Michigan State University) Michigan State University researchers have found that when triclosan, a substance that reduces or prevents bacteria from growing, is combined with an antibiotic called tobramycin, it kills the cells that protect cystic fibrosis bacteria, known as Pseudomonas aeruginosa, by up to 99.9 percent. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - May 17, 2018 Category: Biology Source Type: news