A local company ’s pig heart is still beating inside of a human. Now it’s time to ‘relentlessly’ make more organs.
The first successful transplant of a pig heart into a human patient happened two weeks ago. (Source: bizjournals.com Health Care News Headlines)
Source: bizjournals.com Health Care News Headlines - January 21, 2022 Category: Health Management Authors: Sara Gilgore Source Type: news

Variation in Heart-Transplant Rates Remains Despite Change in Allocation Policy Variation in Heart-Transplant Rates Remains Despite Change in Allocation Policy
Despite the recent change in heart-allocation policy, substantial center-level and regional variation in likelihood of transplant remains, according to a new analysis.Reuters Health Information (Source: Medscape Transplantation Headlines)
Source: Medscape Transplantation Headlines - January 20, 2022 Category: Transplant Surgery Tags: Transplantation News Source Type: news

U.S. Researchers Test Pig-to-Human Transplant in Donated Body
Researchers on Thursday reported the latest in a surprising string of experiments in the quest to save human lives with organs from genetically modified pigs. This time around, surgeons in Alabama transplanted a pig’s kidneys into a brain-dead man—a step-by-step rehearsal for an operation they hope to try in living patients possibly later this year. “The organ shortage is in fact an unmitigated crisis and we’ve never had a real solution to it,” said Dr. Jayme Locke of the University of Alabama at Birmingham, who led the newest study and aims to begin a clinical trial of pig kidney transplants....
Source: TIME: Health - January 20, 2022 Category: Consumer Health News Authors: LAURAN NEERGAARD / AP Tags: Uncategorized healthscienceclimate Source Type: news

Lifestyle changes can be critical for kidney transplant patients' long-term survival
ROCHESTER, Minn. — Cancer, infections and heart disease pose the greatest risk to kidney transplant recipients ― not organ rejection ― according to a recently published Mayo Clinic study. Researchers discovered that recipient death due to factors other than organ rejection is the leading cause for transplanted kidney loss. Only 1 in 4 transplanted kidney losses were caused by organ rejection. "Immunosuppression medication to prevent rejection is often the focus when caring for patients posttransplant.… (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - January 17, 2022 Category: Databases & Libraries Source Type: news

Donor Hearts After Circulatory Death: Feasible, a Vital Resource Donor Hearts After Circulatory Death: Feasible, a Vital Resource
The US would see almost 300 more heart transplants per year with wider use of donor hearts procured after circulatory death, rather than the current standard of brain death, researchers estimate.Medscape Medical News (Source: Medscape General Surgery Headlines)
Source: Medscape General Surgery Headlines - January 14, 2022 Category: Surgery Tags: Cardiology News Source Type: news

Patient in Groundbreaking Pig Heart Transplant Has a Criminal Record
David Bennett Sr. was involved in a serious assault nearly 35 years ago, court records show. Such histories should not disqualify patients, his doctors said. (Source: NYT Health)
Source: NYT Health - January 14, 2022 Category: Consumer Health News Authors: Roni Caryn Rabin Tags: your-feed-science Transplants Murders, Attempted Murders and Homicides Assaults Genetic Engineering University of Maryland Medical Center Source Type: news

Pig heart transplant recipient stabbed a man seven times in 1988 leaving him wheelchair-bound
David Bennett allegedly attacked Edward Shumaker after he caught his then-wife sitting in the man's lap while they were talking and drinking. Shumaker was paralyzed until he died. (Source: the Mail online | Health)
Source: the Mail online | Health - January 14, 2022 Category: Consumer Health News Source Type: news

Hospital: Poor health only criteria for pig heart transplant
A Maryland hospital is defending its decision to transplant a pig's heart into a dying man following reports that the patient had a criminal record (Source: ABC News: Health)
Source: ABC News: Health - January 13, 2022 Category: Consumer Health News Tags: Health Source Type: news

What Does a Pig-to-Human Heart Transplant Mean for Medicine? What Does a Pig-to-Human Heart Transplant Mean for Medicine?
It was brilliant and courageous,'but it's always in the implementation that we have to hold our breath,'says a prominent specialist, proposing that the tough questions be asked now rather than later.Medscape Medical News (Source: Medscape Cardiology Headlines)
Source: Medscape Cardiology Headlines - January 12, 2022 Category: Cardiology Tags: Cardiology News Source Type: news

Are pigs the future of organ transplants? This company is betting the farm on it
The first successful transplant of a pig heart into a human has grabbed headlines — and accelerates the path forward for the Maryland biotech behind that genetically modified organ. The surgery, performed Friday at the University of Maryland Medical Center in Baltimore, made patient David Bennett the first recipient of a heart developed by Blacksburg, Virginia's Revivicor Inc. , a wholly owned subsidiary of Silver Spring’s United Therapeutics Corp. (NASDAQ: UTHR). It puts the company a step closer… (Source: bizjournals.com Health Care:Physician Practices headlines)
Source: bizjournals.com Health Care:Physician Practices headlines - January 12, 2022 Category: American Health Authors: Sara Gilgore Source Type: news

UK doctors could soon begin giving heart transplant patients organs from PIGS after US case
Many experts see the field - known as xenotransplantation - as a solution to a UK - and international - shortage of human organ donors that is expected to get worse as we live longer. (Source: the Mail online | Health)
Source: the Mail online | Health - January 12, 2022 Category: Consumer Health News Source Type: news

In Breakthrough Transplant, Man Receives Genetically Modified Pig Heart
TUESDAY, Jan. 11, 2022 -- In a medical first, doctors from the University of Maryland have implanted the heart of a genetically modified pig in a 57-year-old man facing the final stages of heart disease. The surgical feat, known as... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - January 11, 2022 Category: Pharmaceuticals Source Type: news

Pig heart recipient continues to recover from transplant
The man who received the first pig heart transplant is continuing to recover from the experimental surgery (Source: ABC News: Health)
Source: ABC News: Health - January 11, 2022 Category: Consumer Health News Tags: Health Source Type: news

Are pigs the future of organ transplants? This Md. company is betting the farm on it.
The first successful transplant of a pig heart into a human has grabbed headlines — and accelerates the path forward for the Maryland biotech behind that genetically modified organ. The surgery, performed Friday at the University of Maryland Medical Center in Baltimore, made patient David Bennett the first recipient of a heart developed by Blacksburg, Virginia's Revivicor Inc. , a wholly owned subsidiary of Silver Spring’s United Therapeutics Corp. (NASDAQ: UTHR). It puts the company a step closer… (Source: bizjournals.com Health Care:Pharmaceuticals headlines)
Source: bizjournals.com Health Care:Pharmaceuticals headlines - January 11, 2022 Category: Pharmaceuticals Authors: Sara Gilgore Source Type: news

I thought Dad's pig heart transplant was delirium
David Bennett, 57, is the first person in the world to receive a heart transplant from a genetically-modified pig. (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - January 11, 2022 Category: Consumer Health News Source Type: news

Three ethical issues around pig heart transplants
A pig's heart has been used in a human transplant operation - what are the questions to consider? (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - January 11, 2022 Category: Consumer Health News Source Type: news

Why pig-to-human heart transplant is for now only a last resort
Analysis: As doctors monitor world ’s first human recipient of pig heart, safety and ethical concerns remainThe world ’s first transplant of a genetically altered pig heart into an ailing human is alandmark for medical science, but the operation, and the approach more broadly, raise substantial safety and ethical concerns.Surgeons at the University of Maryland Medical Center spent eight hours on Friday evening transplanting the heart from the pig into 57-year-old David Bennett, who had been in hospital for more than a month with terminal heart failure.Continue reading... (Source: Guardian Unlimited Science)
Source: Guardian Unlimited Science - January 11, 2022 Category: Science Authors: Ian Sample Science editor Tags: Medical research Health Science Maryland Gene editing US news Society World news Genetics Heart disease Biology Animal welfare Animals Organ donation Source Type: news

Health Highlights: Jan. 11, 2022
  In a transplant first, man receives genetically modified pig heart. Doctors from the University of Maryland performed the breakthrough surgery on a 57-year-old man facing the final stages of heart disease, raising the possibility that more... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - January 11, 2022 Category: General Medicine Source Type: news

In Breakthrough Transplant, Man Receives Genetically Modified Pig Heart
TUESDAY, Jan. 11, 2022 -- In a medical first, doctors from the University of Maryland have implanted the heart of a genetically modified pig in a 57-year-old man facing the final stages of heart disease. The surgical feat, known as... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - January 11, 2022 Category: General Medicine Source Type: news

Man gets genetically-modified pig heart in world-first transplant
David Bennett, 57, is doing well three days after the experimental surgery, doctors say. (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - January 11, 2022 Category: Consumer Health News Source Type: news

First pig heart to human transplant is a game-changer, say surgeons
In a world first, a pig heart has been successfully transplanted into a human by surgeons in the US. (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - January 11, 2022 Category: Consumer Health News Source Type: news

AHA News: Device Keeps 35-Year-Old's Heart Pumping as He Awaits a Transplant
Title: AHA News: Device Keeps 35-Year-Old's Heart Pumping as He Awaits a TransplantCategory: Health NewsCreated: 1/10/2022 12:00:00 AMLast Editorial Review: 1/11/2022 12:00:00 AM (Source: MedicineNet Heart General)
Source: MedicineNet Heart General - January 11, 2022 Category: Cardiology Source Type: news

In Breakthrough Transplant, Man Receives Genetically Modified Pig Heart
Title: In Breakthrough Transplant, Man Receives Genetically Modified Pig HeartCategory: Health NewsCreated: 1/11/2022 12:00:00 AMLast Editorial Review: 1/11/2022 12:00:00 AM (Source: MedicineNet Heart General)
Source: MedicineNet Heart General - January 11, 2022 Category: Cardiology Source Type: news

In a First, Man Receives a Heart From a Genetically Altered Pig
The breakthrough may lead one day to new supplies of animal organs for transplant into human patients. (Source: NYT Health)
Source: NYT Health - January 11, 2022 Category: Consumer Health News Authors: Roni Caryn Rabin Tags: your-feed-science Transplants Kidneys Genetics and Heredity Pigs Surgery and Surgeons Genetic Engineering Heart Cloning University of Maryland Medical Center Baltimore (Md) Source Type: news

In a medical first, a man with terminal heart disease gets a transplant of genetically modified pig heart
A 57-year-old Maryland man is doing well three days after receiving a genetically modified pig heart in a first-of-its-kind transplant surgery, University of Maryland Medicine said in a news... #newsrelease (Source: Reuters: Health)
Source: Reuters: Health - January 11, 2022 Category: Consumer Health News Source Type: news

Pig Heart Successfully Transplanted to Man Pig Heart Successfully Transplanted to Man
It's the first successful transplant of a genetically modified animal heart into a human, in this case a 57-year-old man with no other treatment options, said officials at the University of Maryland.Medscape Medical News (Source: Medscape Cardiology Headlines)
Source: Medscape Cardiology Headlines - January 11, 2022 Category: Cardiology Tags: Transplantation News Source Type: news

Maryland doctors transplant pig ’s heart into human patient in medical first
Patient is doing well three days after the highly experimental surgery, doctors say, though it’s too soon to know if it is a success #successpatient #humanpatient (Source: Reuters: Health)
Source: Reuters: Health - January 11, 2022 Category: Consumer Health News Source Type: news

U.S. surgeons transplant pig heart into human patient in medical first
In a medical first, doctors transplanted a pig heart into a patient in a last-ditch effort to save his life. Three days after the highly experimental surgery, a Maryland hospital says that the patient is doing well. (Source: CBC | Health)
Source: CBC | Health - January 10, 2022 Category: Consumer Health News Tags: News/Health Source Type: news

Man Receives Transplanted Heart from Genetically Modified Pig
The procedure, performed last Friday, is a milestone in a long effort to boost the number of organs available for safe transplantation. (Source: The Scientist)
Source: The Scientist - January 10, 2022 Category: Science Tags: News & Opinion Source Type: news

In 1st, US surgeons transplant pig heart into human patient
Doctors have transplanted a pig heart into a patient in an effort to save life. (Source: ABC News: Health)
Source: ABC News: Health - January 10, 2022 Category: Consumer Health News Tags: Health Source Type: news

Surgeons Transplant Pig Heart Into Human Patient For the First Time Ever
In a medical first, doctors transplanted a pig heart into a patient in a last-ditch effort to save his life and a Maryland hospital said Monday that he’s doing well three days after the highly experimental surgery. While it’s too soon to know if the operation really will work, it marks a step in the decades-long quest to one day use animal organs for life-saving transplants. Doctors at the University of Maryland Medical Center say the transplant showed that a heart from a genetically modified animal can function in the human body without immediate rejection. The patient, David Bennett, 57, knew there was no gua...
Source: TIME: Health - January 10, 2022 Category: Consumer Health News Authors: Carla K. Johnson / AP Tags: Uncategorized healthscienceclimate medicine News Desk wire Source Type: news

Maryland doctors transplant pig ’s heart into human patient in medical first
Patient is doing well three days after the highly experimental surgery, doctors say, though it ’s too soon to know if it is a successIn a medical first, doctors in Maryland have transplanted a genetically modified pig ’s heart into a human patient in a last-ditch effort to save his life.Doctors at the University of Maryland medical center said Monday that the patient was doing well three days after the highly experimental surgery, though it is too soon to know if the operation has been a success.Continue reading... (Source: Guardian Unlimited Science)
Source: Guardian Unlimited Science - January 10, 2022 Category: Science Authors: Guardian staff and agencies Tags: Maryland Medical research US news Science Source Type: news

Doctors transplant a genetically modified pig heart into a human for the 1st time
(Source: NPR Health and Science)
Source: NPR Health and Science - January 10, 2022 Category: Consumer Health News Authors: The Associated Press Source Type: news

US Surgeons Transplant Pig Heart Into Human Patient
“It was either die or do this transplant. I want to live. I know it’s a shot in the dark, but it’s my last choice,” 57-year-old patient David Bennett said a day before the surgery, (Source: Science - The Huffington Post)
Source: Science - The Huffington Post - January 10, 2022 Category: Science Source Type: news

US doctors transplant a pig heart into a patient in an experimental, last-ditch effort to save his life
(Source: ABC News: Health)
Source: ABC News: Health - January 10, 2022 Category: Consumer Health News Tags: Health Source Type: news

First-ever pig-to-human heart transplant offers hope for thousands in need of organs
The breakthrough by doctors at the University of Maryland offers hope for those who languish and sometimes die while on organ transplant waitlists. #universityofmaryland #breakthrough (Source: Reuters: Health)
Source: Reuters: Health - January 10, 2022 Category: Consumer Health News Source Type: news

In a First, Man Receives a Heart From a Genetically Altered Pig
The breakthrough may lead one day to new supplies of animal organs for transplant into human patients. #breakthrough #manreceives #humanpatients (Source: Reuters: Health)
Source: Reuters: Health - January 10, 2022 Category: Consumer Health News Source Type: news

AHA News: Device Keeps 35-Year-Old's Heart Pumping as He Awaits a Transplant
MONDAY, Jan. 10, 2022 (American Heart Association News) -- Jeff and Christina Russ – and their beagle mix, Lacey – were walking their regular 2-mile loop through their neighborhood in Cuyahoga Falls, Ohio, when Jeff began to feel winded. It was... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - January 10, 2022 Category: General Medicine Source Type: news

Two big milestones for one special pediatric patient
Jaron Rosser was the 100th pediatric patient to get a heart transplant at Atrium Health Levine Children ’s Hospital. Levine Children’s celebrated the big milestone after his transplant last December, and cheered him on as he returned home to Asheville, ready for his new life with his new heart. Then, Rosser came back to LCH. He developed pain and fatigue, so his team at Levine Children’s came t ogether – and pulled in more specialists – to determine what was wrong and how to help him. They… (Source: bizjournals.com Health Care News Headlines)
Source: bizjournals.com Health Care News Headlines - January 1, 2022 Category: Health Management Authors: Atrium Health Source Type: news

Posttraumatic growth in youth, young adults, and caregivers who experienced solid organ transplant - Triplett KN, Mayersohn GS, Masood SS, Pickwith K, Mbroh H, Killian M.
OBJECTIVE: To explore posttraumatic growth (PTG) in pediatric patients who have undergone solid organ transplant (SOT) and their caregivers, and to examine potential correlates of PTG. METHOD: Youth and young adults with a history of SOT (heart, ki... (Source: SafetyLit)
Source: SafetyLit - December 29, 2021 Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news

Israel Begins Trial of Fourth COVID-19 Vaccine Dose
(JERUSALEM) — Israel has begun trials of a fourth dose of coronavirus vaccine in what is believed to be the first study of its kind. The trial began at Sheba Medical Center, outside Tel Aviv, with 150 medical personnel who received a booster dose in August receiving a fourth shot of the Pfizer/BioNTech vaccine. The staff receiving the additional dose were tested and found to have low antibody levels. The trial came as Israeli officials have considered rolling out a second tranche of booster shots to its population as the country grapples with rising infections with the new omicron variant. Read more: Vaccine Scientis...
Source: TIME: Health - December 27, 2021 Category: Consumer Health News Authors: Associated Press Tags: Uncategorized COVID-19 Israel News wire Source Type: news

FDA Approves Two New Indications for XARELTO ® (rivaroxaban) to Help Prevent and Treat Blood Clots in Pediatric Patients
RARITAN, NJ, Dec. 20, 2021 – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today that the U.S. Food and Drug Administration (FDA) has approved two pediatric indications for XARELTO® (rivaroxaban): the treatment of venous thromboembolism (VTE, or blood clots) and reduction in the risk of recurrent VTE in patients from birth to less than 18 years after at least five days of initial parenteral (injected or intravenous) anticoagulant treatment; and thromboprophylaxis (prevention of blood clots and blood-clot related events) in children aged two years and older with congenital heart disease w...
Source: Johnson and Johnson - December 21, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news

Pandemic backlogs put life at risk, says Winnipeg man waiting for kidney, heart transplants
The pandemic has left Manitoba's transplant program playing catchup. Now, transplant candidates and their donors face staffing shortages, surgery backlogs and longer waits for diagnostics. (Source: CBC | Health)
Source: CBC | Health - December 20, 2021 Category: Consumer Health News Tags: News/Canada/Manitoba Source Type: news

UCLA gene therapy gives new life to girl born with fatal immune disorder
In every visible way, Marley Gaskins is an average 12-year-old — she enjoys painting, playing online games like Roblox with her friends and taking ukulele lessons. But until recently, her life was far from normal.Marley was born with a one-in-a-million genetic disorder called leukocyte adhesion deficiency-1, or LAD-1, which cripples the immune system and results in recurring infections, coupled with slow wound healing.“She started getting what looked like ant bites on her skin when she turned 1,” said Marley’s mother, Tamara Hogue. “When she was 3, she got a really big skin abscess on her stom...
Source: UCLA Newsroom: Health Sciences - December 17, 2021 Category: Universities & Medical Training Source Type: news

Heart Transplant Successful in Young Man Who Survived Severe COVID-19
THURSDAY, Dec. 16, 2021 -- After nearly dying from a severe case of COVID-19, a young male patient received a successful heart transplant even as he was recuperating from his infection while on a ventilator, a new case study reports. The transplant... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - December 16, 2021 Category: General Medicine Source Type: news

New Data from MajesTEC-1 Study Show Continued Deep and Durable Responses of Teclistamab (BCMAxCD3 Bispecific Antibody) in Treatment of Heavily Pretreated Patients with Multiple Myeloma
The objective responsive rate observed in this study suggests a potential benefit for many patients with triple-class exposed disease with an off-the-shelf therapy.”As of September 2021, 165 patients were treated with teclistamab at the SC 1.5 mg/kg dose across both Phase 1 and Phase 2 of MajesTEC-1.1 The primary objectives of the MajesTEC-1 Phase 1 study (NCT03145181) were to identify the recommended SC RP2D (part 1) and characterize the safety and tolerability of teclistamab at the RP2D (part 2). The primary objective of the MajesTEC-1 Phase 2 study (NCT04557098) was to evaluate the efficacy of teclistamab at the R...
Source: Johnson and Johnson - December 13, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news

New Data from CARTITUDE-1 Study Show Continued Deep and Durable Responses of Ciltacabtagene Autoleucel (cilta-cel) in Treatment of Heavily Pretreated Patients with Multiple Myeloma
ATLANTA, Ga., December 12, 2021 – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today longer-term results from the Phase 1b/2 CARTITUDE-1 study evaluating the efficacy and safety of ciltacabtagene autoleucel (cilta-cel), an investigational B-cell maturation antigen (BCMA)-directed chimeric antigen receptor T-cell (CAR-T) therapy administered as a single infusion, in the treatment of patients with relapsed and/or refractory multiple myeloma. The data, featured as an oral presentation at the American Society of Hematology (ASH) 2021 Annual Meeting (Abstract #549) and selected as part of the Hi...
Source: Johnson and Johnson - December 12, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news

Janssen Presents Updated Results Evaluating First-in-Class Talquetamab (GPRC5DxCD3 Bispecific Antibody) in Heavily Pretreated Patients with Multiple Myeloma
ATLANTA, Ga., December 11, 2021– The Janssen Pharmaceutical Companies of Johnson & Johnson announced today updated results from the MonumenTAL-1 Phase 1 first-in-human dose-escalation study of talquetamab (NCT03399799). Talquetamab is the only investigational off-the-shelf T cell redirecting bispecific antibody in clinical development targeting both GPRC5D, a novel multiple myeloma target, and CD3 on T cells.[1] Results from the study show that no new safety signals were observed with longer follow-up.1 Heavily pretreated patients with multiple myeloma treated with talquetamab at the recommended subcutaneous (SC)...
Source: Johnson and Johnson - December 11, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news

New Clinical and Real-World Data Support Use of DARZALEX ® (daratumumab) in Patients with Newly Diagnosed Multiple Myeloma
ATLANTA, Ga., December 11, 2021 – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today new analyses illustrating responses that first-line treatment with DARZALEX® (daratumumab)-based regimens may be able to achieve, including a potential survival benefit for DARZALEX® in combination with lenalidomide and dexamethasone (Rd). Updated data from the randomized Phase 2 GRIFFIN study in transplant-eligible patients and real-world evidence in transplant-ineligible patients were presented at the American Society of Hematology (ASH) 2021 Annual Meeting. Data from the GRIFFIN study will also b...
Source: Johnson and Johnson - December 11, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news

A regenerative bridge to transplant
At 34, Steven Graham has already beaten the odds. Born with a heart defect, doctors predicted that he would not live past 30. But over the years and a series of pacemakers, his heart was giving out, and he needed a transplant. Complicating matters, Steven's declining cardiac muscle was also damaging his lungs. His physicians said he would need a heart and lung transplant. Then came the tough news that they no longer could help… (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - December 1, 2021 Category: Databases & Libraries Source Type: news