Joseph Wynne, MD, Discusses Developments in the Field of Acute Lymphoblastic Leukemia
The ALL expert spoke about new research in the field and how it has changed the landscape for this disease. (Source: CancerNetwork)
Source: CancerNetwork - January 29, 2020 Category: Cancer & Oncology Authors: Hannah Slater Source Type: news

Dasatinib Tops Imatinib for Ph + Acute Lymphoblastic Leukemia
Four - year cumulative risk of any relapse lower for dasatinib in the context of intensive chemotherapy (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - January 21, 2020 Category: Cancer & Oncology Tags: Oncology, Pathology, Pediatrics, Pharmacy, Journal, Source Type: news

Dasatinib Tops Imatinib for Ph & #43; Acute Lymphoblastic Leukemia
TUESDAY, Jan. 21, 2020 -- Dasatinib is associated with improved survival for pediatric patients with Philadelphia chromosome-positive acute lymphoblastic leukemia (ALL), according to a study published online Jan. 16 in JAMA Oncology. Shuhong Shen,... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - January 21, 2020 Category: Pharmaceuticals Source Type: news

Defining the Landscape of Mutations Present in Pediatric Acute Lymphoblastic Leukemia
This research has the potential to aid in the development of new strategies for early detection of relapse in pediatric patients with ALL, and the development of treatments to counter clinical occurrence. (Source: CancerNetwork)
Source: CancerNetwork - January 20, 2020 Category: Cancer & Oncology Authors: Hannah Slater Source Type: news

Children treated for acute lymphoblastic leukemia may grow up to have heart problems, study finds
(Natural News) Acute lymphoblastic leukemia (ALL) is a type of cancer that affects the blood and bone marrow. It is the most common type of cancer developed by children. Although ALL is known to progress quickly, advances in modern medicine have increased the survival rate of children with this disease. However, a recent study by researchers... (Source: NaturalNews.com)
Source: NaturalNews.com - December 24, 2019 Category: Consumer Health News Source Type: news

Acute leukemia patients treated with common therapy have increased risk for heart failure
(University of Pennsylvania School of Medicine) Patients with acute lymphoblastic leukemia (ALL) or acute myeloid leukemia (AML) who are treated with anthracyclines are at a heightened risk of heart failure -- most often within one year of exposure to the chemotherapy treatment, according to a new study led by researchers at Penn Medicine. To help identify a patient's risk for heart failure following the treatment, researchers developed a risk score (0 to 21) based on clinical and echographic variables. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - December 17, 2019 Category: Cancer & Oncology Source Type: news

Immunotherapy drug improves outcomes for some children with relapsed leukemia
Blinatumomab is superior to standard chemotherapy for children and young adults with high- or intermediate-risk B-cell acute lymphoblastic leukemia that has relapsed. (Source: National Institutes of Health (NIH) News Releases)
Source: National Institutes of Health (NIH) News Releases - December 10, 2019 Category: American Health Source Type: news

Immunotherapy drug improves outcomes for some children with relapsed leukemia
(NIH/National Cancer Institute) New findings from a clinical trial show that treatment with the immunotherapy drug blinatumomab is superior to standard chemotherapy for children and young adults with high- or intermediate-risk B-cell acute lymphoblastic leukemia (B-ALL) that has relapsed. Those treated with blinatumomab had longer survival, experienced fewer severe side effects, had a higher rate of undetectable residual disease, and were more likely to proceed to a stem cell transplant. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - December 10, 2019 Category: Cancer & Oncology Source Type: news

New approach to treating incurable leukemia in children discovered
(University of Zurich) Acute lymphoblastic leukemia is the most common form of cancer affecting children in Switzerland and, unfortunately, is often incurable. Researchers from the University of Zurich and the University Children's Hospital Zurich have now found a way to stop the driving force behind this type of leukemia at a molecular level and develop a targeted therapy. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - November 25, 2019 Category: Cancer & Oncology Source Type: news

Prophylactic Cranial Irradiation May Not Be Needed in Children With ALL Prophylactic Cranial Irradiation May Not Be Needed in Children With ALL
In children with acute lymphoblastic leukemia (ALL) at risk for central nervous system (CNS) relapse, a higher dose of chemotherapy plus two extra doses of intrathecal therapy during early induction can obviate the need for prophylactic cranial irradiation, researchers say.Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - November 12, 2019 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

Extension of the Notch intracellular domain ankyrin repeat stack by NRARP promotes feedback inhibition of Notch signaling
Canonical Notch signaling relies on regulated proteolysis of the receptor Notch to generate a nuclear effector that induces the transcription of Notch-responsive genes. In higher organisms, one Notch-responsive gene that is activated in many different cell types encodes the Notch-regulated ankyrin repeat protein (NRARP), which acts as a negative feedback regulator of Notch responses. Here, we showed that NRARP inhibited the growth of Notch-dependent T cell acute lymphoblastic leukemia (T-ALL) cell lines and bound directly to the core Notch transcriptional activation complex (NTC), requiring both the transcription factor RB...
Source: Signal Transduction Knowledge Environment - November 5, 2019 Category: Science Authors: Jarrett, S. M., Seegar, T. C. M., Andrews, M., Adelmant, G., Marto, J. A., Aster, J. C., Blacklow, S. C. Tags: STKE Research Articles Source Type: news

Exercise Intolerance May Harm Neurocognition in ALL Survivors
MONDAY, Oct. 21, 2019 -- For adult survivors of childhood acute lymphoblastic leukemia (ALL), exercise intolerance is associated with worse neurocognitive outcomes, according to a study published online Oct. 21 in Cancer. Nicholas S. Phillips, M.D.,... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - October 21, 2019 Category: Pharmaceuticals Source Type: news

Can More Exercise Improve Thinking Skills in Cancer Survivors?
MONDAY, Oct. 21, 2019 -- Boosting exercise capacity may protect the mental functioning of childhood leukemia survivors, according to a new study. Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. Due to their disease and... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - October 21, 2019 Category: General Medicine Source Type: news

Invasive Pulmonary Aspergillosis in Acute Leukemia in the Era of New Antifungal Treatment and Prophylaxis Is Still Frequent, Even in Patients with Acute Lymphoblastic Leukemia, and Adversely Affects the Overall Treatment Outcome. Results of a 5-Year Study
Conference abstracts (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 6, 2019 Category: Respiratory Medicine Authors: MeganB Source Type: news

The Incidence of Invasive Fungal Infections in Children, Adolescents and Young Adults with Acute Lymphoblastic Leukaemia/Lymphoma Treated with the UKALL2011 Protocol: a Multicentre Retrospective Study
Conference abstracts (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 6, 2019 Category: Respiratory Medicine Authors: MeganB Source Type: news

Cancer sufferer, five, who has always wanted to be a tattoo artist lives out her dream
The five-year-old girl, known only as Maja, is battling acute lymphoblastic leukaemia. She visited a local tattoo parlour in Cleveland, Ohio, where she was shown all the tools. (Source: the Mail online | Health)
Source: the Mail online | Health - September 27, 2019 Category: Consumer Health News Source Type: news

Amgen announces positive results from two Phase 3 BLINCYTO ® (blinatumomab) studies In pediatric patients with relapsed acute lymphoblastic leukemia
Amgen (NASDAQ:AMGN) today announced that the results of a prespecified interim analysis of an open-label, randomized, controlled global multicenter Phase 3 trial (20120215) showed that the primary endpoint of event-free survival was met. The study evaluated the efficacy, safety and tolerability of BLINCYTO® (blinatumomab) compared to conventional consolidation chemotherapy in pediatric patients with (Source: World Pharma News)
Source: World Pharma News - September 25, 2019 Category: Pharmaceuticals Tags: Featured Amgen Business and Industry Source Type: news

Micafungin As Antifungal Prophylaxis during Induction Phase of Chemotherapy in Pediatric Acute Lymphoblastic Leukemia
Conference abstracts (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - September 22, 2019 Category: Respiratory Medicine Authors: MeganB Source Type: news

Medicare Now Covers CAR T-Cell Therapy for Approved Cancers
A promising and expensive type of immunotherapy, called CAR T-cell therapy, is now covered by Medicare. This news may affect mesothelioma patients in the future. Chimeric antigen receptor T-cell, or CAR T-cell, therapy involves the laboratory reprogramming of a patient’s T cells, which are a type of white blood cell responsible for protecting the body against infection and disease. The T cells are genetically modified to better recognize and attack cancer. The U.S. Food and Drug Administration has approved the immunotherapy procedure for non-Hodgkin lymphoma and B-cell precursor acute lymphoblastic leukemia. It is...
Source: Asbestos and Mesothelioma News - September 19, 2019 Category: Environmental Health Authors: Matt Mauney Source Type: news

New leukaemia drug produces 'very positive results' in a trial of 'incurable' patients
Ten-year-old Austin Sweeney has acute lymphoblastic leukaemia. He took part in the Great Ormond Street Hospital trial in London. He is pictured with his father Scott, mother and sister. (Source: the Mail online | Health)
Source: the Mail online | Health - September 2, 2019 Category: Consumer Health News Source Type: news

Delays in CAR T-Cell Treatment Cost Patients, Society
Delays in CAR T-cell therapy may significantly decrease gains in survival and productivity for patients with diffuse large B-cell lymphoma and pediatric  acute lymphoblastic leukemia. (Source: CancerNetwork)
Source: CancerNetwork - August 30, 2019 Category: Cancer & Oncology Authors: Leah Lawrence Source Type: news

Overweight, Obesity May Up Early Mortality Risk in Pediatric ALL
MONDAY, Aug. 5, 2019 -- For Mexican children with acute lymphoblastic leukemia (ALL), overweight and obesity are predictors of early mortality, according to a study published online July 18 in BMC Cancer. Juan Carlos N úñez-Enríquez, M.D., from... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - August 5, 2019 Category: Pharmaceuticals Source Type: news

Acute Leukemia | Medscape Acute Leukemia | Medscape
Acute forms of leukemia include acute myeloid leukemia and acute lymphoblastic leukemia, also known as lymphoblastic lymphoma. (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - July 3, 2019 Category: Consumer Health News Tags: Resource Center Source Type: news

Miraculous children's therapy that could finally save adults with cancer
Scott Davies, a driving instructor from Nottingham, had a form of blood cancer - acute lymphoblastic leukaemia, which affects 650 UK adults and children each year. (Source: the Mail online | Health)
Source: the Mail online | Health - July 2, 2019 Category: Consumer Health News Source Type: news

Anesthesia Tied to Neurocognitive Impairment in Childhood ALL Survivors
TUESDAY, June 25, 2019 -- Multiple exposures to general anesthesia may be associated with neurocognitive impairment and brain imaging abnormalities in long-term survivors of childhood acute lymphoblastic leukemia (ALL), according to a study... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - June 25, 2019 Category: Pharmaceuticals Source Type: news

Virginia family of eight stuck in Colorado after 16-year-old son's 'mono' turned out to be leukemia 
Marshall Thomas, 16, of Suffolk, Virginia, was diagnosed with B-cell acute lymphoblastic leukemia on Saturday in Colorado after doctors previously believe he had mononucleosis. (Source: the Mail online | Health)
Source: the Mail online | Health - June 19, 2019 Category: Consumer Health News Source Type: news

Amgen Announces BLINCYTO ® (blinatumomab) Five-Year Overall Survival Data At EHA 2019
Phase 2 Single-Arm BLAST Study Shows Median Overall Survival of 36.5 Months in Patients With Minimal Residual Disease-Positive Acute Lymphoblastic Leukemia More Than Half of Patients who Achieved an MRD-Negative Complete Response Still Alive at Five Years Only CD19-Targeted Immuno-oncology Therapy With Five-Year Survival Data THOUSAND OAKS, Calif., June 15, 2019 /PRNewswire/ -- Amgen (NASDAQ:AMGN) today announced the five-year overall survival (OS) analysis from the single-arm, Phase 2 BLAST study that evaluated BLINCYTO® (blinatumomab) in patients with minimal residual disease (MRD)-positive acute lympho...
Source: Amgen News Release - June 16, 2019 Category: Pharmaceuticals Tags: Uncategorized Source Type: news

New research paves the way for safer leukemia treatments
(Children's Cancer Institute Australia) Researchers have discovered a new, safer way to treat a type of childhood leukaemia: T-cell acute lymphoblastic leukemia (T-ALL). Published in Science Translational Medicine, this joint research by Children's Cancer Institute (Australia), VIB-KU Leuven and UK Dementia Research Institute, is an important breakthrough in the treatment of T-ALL. This involves drugs which inhibit the enzyme 'gamma-secretase'. Previously, these inhibitors were unsuitable for treating children because of their toxicity. This research may be the solution. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - May 30, 2019 Category: Cancer & Oncology Source Type: news

Recovery twice as hard for survivors of childhood acute lymphoblastic leukemia
(University of Montreal) The cardiorespiratory fitness of survivors of childhood acute lymphoblastic leukemia is 22% worse than that general Canadian population,and genetics might play a role, an UdeM researcher finds. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - May 29, 2019 Category: Cancer & Oncology Source Type: news

SERENA LIPSCOMB got her cancer all-clear aged eight... but the physical and mental toll never ends
SERENA LIPSCOMB, now 23, was living in Essex with her mother Melanie and father Ian when she was diagnosed with acute lymphoblastic leukaemia. (Source: the Mail online | Health)
Source: the Mail online | Health - May 18, 2019 Category: Consumer Health News Source Type: news

Florida's medical police state abducts healthy three-year-old from parents for refusing unnecessary chemotherapy treatments
(Natural News) Another American family is facing a barrage of persecution from the corrupt medical establishment for refusing chemotherapy treatments for their three-year-old son, Noah – who doesn’t even have cancer, by the way. Young Noah had previously been diagnosed with acute lymphoblastic leukemia at Johns Hopkins All Children’s Hospital in Tampa, Florida, where his... (Source: NaturalNews.com)
Source: NaturalNews.com - May 6, 2019 Category: Consumer Health News Source Type: news

First major study of proteins in patients with acute lymphoblastic leukaemia
(Lund University) The most common form of childhood cancer is acute lymphoblastic leukaemia (ALL). Researchers at Lund University in Sweden, in cooperation with Karolinska Institutet, SciLifeLab and the University of Cambridge, have now carried out the most extensive analysis to date of ALL at the protein level, by studying the activity in over 8 000 genes and proteins. The results show aberrant folding in the DNA string, which in turn affects the genes' activity. The study was recently published in Nature Communications. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 25, 2019 Category: Cancer & Oncology Source Type: news

Model was in shape of his life when his sore throat turned out to be leukemia
William Yank, 21, from Indianapolis, Indiana, was diagnosed with acute lymphoblastic leukemia in June 2018. It was a shock to the college student, who was a model that worked out almost everyday. (Source: the Mail online | Health)
Source: the Mail online | Health - April 24, 2019 Category: Consumer Health News Source Type: news

In the Loop: Gabe's bell to 'honor the fighting, remember the resting, and party on with the survivors'
Gabe Carranza walked into the lobby on the 16th floor of the Mayo Building. It was a walk he'd made more times than he could count over the past three years and 70 days. But this walk was different. It marked the end of Gabe's treatment for?acute lymphoblastic leukemia. The lobby was filled with family, [...] (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - April 2, 2019 Category: Databases & Libraries Source Type: news

Five-year-old who won the nation’s heart in his battle against leukaemia has found a stem-cell donor
Oscar Saxelby-Lee, of St John's, Worcester, was diagnosed with the aggressive blood cancer acute lymphoblastic leukaemia on December 28 last year after his parents noticed bruising. (Source: the Mail online | Health)
Source: the Mail online | Health - March 29, 2019 Category: Consumer Health News Source Type: news

HSCT Remains Standard in Childhood ALL, Despite CAR T-Cells HSCT Remains Standard in Childhood ALL, Despite CAR T-Cells
Clinicians should continue to rely on matched donor stem cell transplants to treat childhood acute lymphoblastic leukemia, while more data on novel CAR T-cell therapies is gathered, says German expert.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
Source: Medscape Hematology-Oncology Headlines - March 26, 2019 Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news

Favorable Outcomes Seen in Long Term for ALLR3 Trial
Findings for risk - stratified tx in B - cell precursor acute lymphoblastic leukemia, late bone marrow relapse (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - March 19, 2019 Category: Cancer & Oncology Tags: Oncology, Pathology, Pediatrics, Journal, Source Type: news

Favorable Outcomes Seen in Long Term for ALLR3 Trial
TUESDAY, March 19, 2019 -- For children with B-cell precursor acute lymphoblastic leukemia with late bone marrow relapse, risk stratification by minimal residual disease seems to be an effective strategy for treatment, according to a study recently... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - March 19, 2019 Category: Pharmaceuticals Source Type: news

Only About Half of Elderly Newly Diagnosed With ALL Receive Tx
FRIDAY, March 8, 2019 -- Almost half of elderly patients newly diagnosed with acute lymphoblastic leukemia (ALL) do not receive treatment, according to a study recently published in Leukemia& Lymphoma. Christopher Kim, M.P.H., Ph.D., from Amgen... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - March 8, 2019 Category: Pharmaceuticals Source Type: news

Washington mom says she's cant vaccinate her five-year-old battling cancer and slams anti-vaxxers
Kai Bonneau, five, of Vancouver, Washington, has been battling acute lymphoblastic leukemia. He can't receive any vaccines until he's done with chemotherapy treatments. (Source: the Mail online | Health)
Source: the Mail online | Health - March 5, 2019 Category: Consumer Health News Source Type: news

Genetic Variant Tied to Leukemia Risk in Hispanic Children
Novel susceptibility locus identified in the ERG gene for acute lymphoblastic leukemia (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - February 25, 2019 Category: Cancer & Oncology Tags: Oncology, Pathology, Pediatrics, Journal, Source Type: news

Genetic Variant Tied to Leukemia Risk in Hispanic Children
MONDAY, Feb. 25, 2019 -- Genetic variations have been identified in the ERG gene that are associated with an increased risk for acute lymphoblastic leukemia (ALL) in Hispanic children, according to a study recently published in Blood. Noting that... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - February 25, 2019 Category: Pharmaceuticals Source Type: news

Mother claims she took her daughter to the GP FIVE TIMES before she was diagnosed with leukaemia
Sharon Mcalister, 35, of Rutherglen, South Lanarkshire, alleges she took her daughter Kaiann to three separate GPs five times before the youngster was told she had acute lymphoblastic leukaemia. (Source: the Mail online | Health)
Source: the Mail online | Health - February 25, 2019 Category: Consumer Health News Source Type: news

Genetic variations in a fourth gene linked to elevated leukemia risk in Hispanic children
(St. Jude Children's Research Hospital) Progress reported on understanding why Hispanic children are more likely to develop acute lymphoblastic leukemia and to die of the disease. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 14, 2019 Category: Cancer & Oncology Source Type: news

Obesity Linked to Adverse Events in Children With Leukemia
WEDNESDAY, Feb. 13, 2019 -- For children with acute lymphoblastic leukemia (ALL), obesity is associated with an increased risk for adverse events during premaintenance chemotherapy, according to a study published in the February issue of Pediatric... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - February 13, 2019 Category: Pharmaceuticals Source Type: news

Allogeneic Transplants No Benefit in Hypodiploid ALL Allogeneic Transplants No Benefit in Hypodiploid ALL
Children with hypodiploid acute lymphoblastic leukemia, a rare form of the disease with a poor prognosis, have no survival benefit from allogeneic transplant and should not undergo it, say US doctors.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - January 25, 2019 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

Addition of BMT Not Indicated in Some With Peds Hypodiploid ALL
WEDNESDAY, Jan. 23, 2019 -- For some children with hypodiploid acute lymphoblastic leukemia (ALL), allogeneic hematopoietic cell transplantation does not improve outcomes compared with chemotherapy alone, according to a study published online Jan.... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - January 23, 2019 Category: Pharmaceuticals Source Type: news

European Commission Approves BLINCYTO(R) (blinatumomab) In Patients With Philadelphia Chromosome Negative Minimal Residual Disease-Positive B-cell Precursor Acute Lymphoblastic Leukemia
BLINCYTO is the First and Only Therapy for Minimal Residual Disease Approved in the European Union Approval Based on Data From the Phase 2 BLAST Study, the Largest Prospective Trial in Minimal Residual Disease-Positive Acute Lymphoblastic Leukemia TH... Biopharmaceuticals, Oncology, Regulatory Amgen, BLINCYTO, blinatumomab, Acute Lymphoblastic Leukemia (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - January 22, 2019 Category: Pharmaceuticals Source Type: news

European Commission Approves BLINCYTO ® (blinatumomab) In Patients With Philadelphia Chromosome Negative Minimal Residual Disease-Positive B-cell Precursor Acute Lymphoblastic Leukemia
BLINCYTO is the First and Only Therapy for Minimal Residual Disease Approved in the European Union Approval Based on Data From the Phase 2 BLAST Study, the Largest Prospective Trial in Minimal Residual Disease-Positive Acute Lymphoblastic Leukemia THOUSAND OAKS, Calif., Jan. 22, 2019 /PRNewswire/ -- Amgen (NASDAQ:AMGN) today announced that the European Commission (EC) has approved an expanded indication for BLINCYTO® (blinatumomab) monotherapy to include adult patients with Philadelphia chromosome negative (Ph-) CD19 positive B-cell precursor acute lymphoblastic leukemia (ALL) in first or second complete remissi...
Source: Amgen News Release - January 22, 2019 Category: Pharmaceuticals Tags: Uncategorized Source Type: news

No substantial benefit from transplantation reported for a high-risk leukemia subtype
(St. Jude Children's Research Hospital) Study led by St. Jude Children's Research Hospital found treatment guided by measuring minimal residual disease was associated with better outcomes for hypodiploid acute lymphoblastic leukemia patients. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - January 18, 2019 Category: Cancer & Oncology Source Type: news