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Salivary biomarkers for oral cancer and pre-cancer screening: a review
ConclusionCombination approach of salivary biomarkers could be used as screening tool to improve early detection and diagnostic precision of oral pre-cancer and cancer.Clinical relevanceThe current findings are of importance for clinicians and researchers to mitigate the challenges in salivary-based diagnosis of oral cancer and to evaluate reliable, specific, and sensitive salivary biomarkers for oral pre-cancer and cancer diagnosis. (Source: Dental Technology Blog)
Source: Dental Technology Blog - January 19, 2018 Category: Dentistry Source Type: news

Quick Test Could Spot Precursor to Esophageal Cancer
FRIDAY, Jan. 19, 2018 -- A pill-sized device that you swallow might help detect a change in the esophagus that can lead to a deadly form of cancer, researchers are reporting. The esophagus is the tube that carries food from your mouth to your... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - January 19, 2018 Category: General Medicine Source Type: news

Oral Contraceptives Reduce Risk for Ovarian and Endometrial Cancers
The effect is especially evident in smokers, the obese and those who exercise infrequently. (Source: NYT Health)
Source: NYT Health - January 19, 2018 Category: Consumer Health News Authors: NICHOLAS BAKALAR Tags: Smoking and Tobacco Birth Control and Family Planning Cancer Ovaries Source Type: news

Medical News Today: How gum disease could lead to cancer
How well do you look after your oral health? New research has now linked the bacteria responsible for gum disease with certain types of cancer. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - January 18, 2018 Category: Consumer Health News Tags: Cancer / Oncology Source Type: news

Can mice really mirror humans when it comes to cancer?
(Michigan State University) A new Michigan State University study is helping to answer a pressing question among scientists of just how close mice are to people when it comes to researching cancer. The findings reveal how mice can actually mimic human breast cancer tissue and its genes, even more so than previously thought, as well as other cancers including lung, oral and esophagus. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - January 18, 2018 Category: Cancer & Oncology Source Type: news

Vitamin deficiency we are all born with
I’ve admired Linus Pauling for years. In 1976, the Nobel Prize-winning chemist gave mega doses of vitamin C to 100 “untreatable” cancer patients. He then compared these so-called terminal patients to patients with the same kind of cancer who didn’t get vitamin C. The patients who received the traditional cancer treatment lived for an average of six months. Pauling’s patients lived — on average — for six years. You’d think that the medical community would have heralded Pauling’s research as a huge breakthrough in cancer treatment. But they didn’t. And they still ...
Source: Al Sears, MD Natural Remedies - January 17, 2018 Category: Complementary Medicine Authors: Cathy Card Tags: Health Natural Cures Nutrition anti-cancer leukemia vitamin vitamin C Source Type: news

Dentists may soon start asking about your sex life
New research from the ‎University of South Florida College of Public Health say dentists should help reduce the rate of oral cancers by checking for symptoms of HPV-related oropharyngeal cancers. (Source: the Mail online | Health)
Source: the Mail online | Health - January 16, 2018 Category: Consumer Health News Source Type: news

Oral health may have an important role in cancer prevention
(University of Helsinki) The bacteria that cause periodontitis, a disease affecting the tissues surrounding the teeth, seems to play a part also in the onset of pancreatic cancer. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 16, 2018 Category: International Medicine & Public Health Source Type: news

Oral Microbiome Tied to H & N Cancer Risk (CME/CE)
(MedPage Today) -- Lower incidence when Corynebacterium, Kingella spp. are abundant (Source: MedPage Today Hematology/Oncology)
Source: MedPage Today Hematology/Oncology - January 15, 2018 Category: Hematology Source Type: news

Medtronic Tweaks its New Pain Pump System
FDA approved a new clinician programmer for use with Medtronic's SynchroMed II intrathecal drug delivery system, an implantable pump that provides targeted drug delivery for patients suffering from chronic pain and severe spasticity. The new technology was designed to simplify therapy management for clinicians by providing them with visual tools and intuitive workflows. The SynchroMed II clinician programmer is a new application that can be used on a tablet and features visual enhancements for a side-by-side comparison of therapy changes. The new app also communicates wirelessly to the SynchroMed II pump with automate...
Source: MDDI - January 12, 2018 Category: Medical Devices Authors: Kristopher Sturgis Tags: Implants Source Type: news

NIDCR Autotherapies Symposium | Thurs., Jan. 25, 8:00 a.m.-12:00 p.m.
Having trouble viewing this email? View it as a Web page.   NIDCR invites you to a scientific symposium: "Autotherapies: Enhancing Our Innate Healing Capacity"  Thursday, January 25, 8:00 am-12:00 pm Lipsett Amphitheater in the NIH Clinical Center (Building 10)NIH Campus, Bethesda, Md. Autotherapies are treatments based on the body's natural ability to heal and protect itself. For example, immunotherapy harnesses the body’s immune cells to fight c...
Source: NIDCR Science News - January 11, 2018 Category: Dentistry Source Type: news

Athenex gets closer to clinical trials in China
Athenex Inc. (Nasdaq:ATNX) has taken another step forward in its efforts to bring an oral breast cancer drug to market in Asia.   The Buffalo-based biopharmaceutical firm received an acceptance from the Chinese Food& Drug Administration for an investigational new drug (IND) application for Oraxol, an oral version of its oral formulation of the chemotherapy formulation paclitaxel. It’s the next in a series of okays from FDA groups across the world, including the United States, South America,… (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - January 8, 2018 Category: Biotechnology Authors: Tracey Drury Source Type: news

UCLA volunteers provide free health care at downtown L.A. mega clinic
With the strongly held belief that access to health care should be available to everyone — not just the insured — nearly 200 volunteers from UCLA joined an effort to provide free services to more than 2,000 people at a three-day Care Harbor community clinic.“Los Angeles is still one of the leading areas of people without insurance or access to care and it’s a problem for the community,” said Dr. Patrick Dowling, professor and chair of the  UCLA Department of Family Medicine, who led the UCLA volunteer contingent at Care Harbor ’s seventh health care mega clinic. “I’...
Source: UCLA Newsroom: Health Sciences - January 4, 2018 Category: Universities & Medical Training Source Type: news

Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors
Immune checkpoint inhibitors (ICIs) targeting the PD-1/PD-L1 axis induce sustained clinical responses in a sizable minority of cancer patients. We found that primary resistance to ICIs can be attributed to abnormal gut microbiome composition. Antibiotics inhibited the clinical benefit of ICIs in patients with advanced cancer. Fecal microbiota transplantation (FMT) from cancer patients who responded to ICIs into germ-free or antibiotic-treated mice ameliorated the antitumor effects of PD-1 blockade, whereas FMT from nonresponding patients failed to do so. Metagenomics of patient stool samples at diagnosis revealed correlati...
Source: ScienceNOW - January 4, 2018 Category: Science Authors: Routy, B., Le Chatelier, E., Derosa, L., Duong, C. P. M., Alou, M. T., Daillere, R., Fluckiger, A., Messaoudene, M., Rauber, C., Roberti, M. P., Fidelle, M., Flament, C., Poirier-Colame, V., Opolon, P., Klein, C., Iribarren, K., Mondragon, L., Jacquelot, Tags: Immunology, Medicine, Diseases reports Source Type: news

Gut microbiome modulates response to anti-PD-1 immunotherapy in melanoma patients
Preclinical mouse models suggest that the gut microbiome modulates tumor response to checkpoint blockade immunotherapy; however, this has not been well-characterized in human cancer patients. Here we examined the oral and gut microbiome of melanoma patients undergoing anti–programmed cell death 1 protein (PD-1) immunotherapy (n = 112). Significant differences were observed in the diversity and composition of the patient gut microbiome of responders versus nonresponders. Analysis of patient fecal microbiome samples (n = 43, 30 responders, 13 nonresponders) showed significantly higher alpha diversity (P
Source: ScienceNOW - January 4, 2018 Category: Science Authors: Gopalakrishnan, V., Spencer, C. N., Nezi, L., Reuben, A., Andrews, M. C., Karpinets, T. V., Prieto, P. A., Vicente, D., Hoffman, K., Wei, S. C., Cogdill, A. P., Zhao, L., Hudgens, C. W., Hutchinson, D. S., Manzo, T., Petaccia de Macedo, M., Cotechini, T., Tags: Immunology, Medicine, Diseases reports Source Type: news

Out - of - Pocket Costs Correlate With Receipt of Cancer Care
Across cancers, higher costs tied to higher rates of oral prescription abandonment, delayed initiation (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - December 28, 2017 Category: Cancer & Oncology Tags: Family Medicine, Geriatrics, Gastroenterology, Gynecology, Internal Medicine, Nephrology, Nursing, Oncology, Pharmacy, Pulmonology, Radiology, Surgery, Urology, Journal, Source Type: news

Studies Link Oral Microbiome to Cancers (CME/CE)
(MedPage Today) -- Higher risk of esophageal, gastric cancers (Source: MedPage Today Gastroenterology)
Source: MedPage Today Gastroenterology - December 22, 2017 Category: Gastroenterology Source Type: news

Cancer Patients Forgo Therapy Because of High OOP Costs Cancer Patients Forgo Therapy Because of High OOP Costs
High out-of-pocket (OOP) costs associated with oral anticancer agents lead many patients to abandon therapy.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - December 22, 2017 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

Oral nonsteroidal anti-inflammatory drugs (NSAIDs) for cancer pain in adults
This Cochrane Review found very low-quality evidence that some people with moderate or severe cancer pain can obtain substantial benefit within one or two weeks, but no high-quality evidence to support or refute the use of NSAIDs +/- opioids for the three steps of the WHO cancer pain ladder. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - December 22, 2017 Category: Consumer Health News Source Type: news

How gum disease affects your overall health: Bacteria from your mouth enters your blood, then contributes to diseases such as cancer
(Natural News) Here’s something to make you check your teeth today: Bacteria in the mouth have long been known to cause various diseases in other parts of the body. While saliva may serve as the first line of defense against unwanted contaminants, some bacteria may be tougher to break down. A study from the Federal University... (Source: NaturalNews.com)
Source: NaturalNews.com - December 21, 2017 Category: Consumer Health News Source Type: news

High out-of-pocket costs may place oral cancer medications out of reach
(University of Pennsylvania School of Medicine) Sticker shock may be leading many insured Americans with cancer to forego treatment with a wide range of oral cancer drugs, suggests a study published online this week in the Journal of Clinical Oncology. The findings point to high out-of-pocket costs as a barrier to potentially life-saving or life-prolonging treatments. As breakthroughs in cancer care continue, the study raises questions about whether patients will able to take advantage of new treatment options. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - December 20, 2017 Category: International Medicine & Public Health Source Type: news

Researchers find possible markers for earlier diagnosis of aggressive tongue cancer
(Case Western Reserve University) Squamous cell carcinoma of the tongue, also known as oral tongue cancer, is an aggressive form of cancer that generally affects older people. in a new study published in Oncotarget, a team of researchers has found that bacterial diversity and richness, and fungal richness, are significantly reduced in tumor tissue compared to their matched non-tumor tissues. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - December 19, 2017 Category: International Medicine & Public Health Source Type: news

Oral Agents for Cancer-Related VTE:'New Standard of Care'Oral Agents for Cancer-Related VTE:'New Standard of Care '
The oral agent rivaroxaban was as effective as subcutaneous dalteparin in controlling VTE in patients with cancer but was associated with a higher rate of bleeding.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - December 18, 2017 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

California Wildfires Spur Asbestos Concerns
Six major wildfires are torching Southern California, covering an area larger than New York City and Boston combined. The Thomas Fire — the largest of the six and the fifth-largest blaze in modern California history — covers 238,500 acres. The other fires have destroyed nearly 260,000 acres, officials said. At least 18,000 homes and other structures are threatened by the fires and more than 1,000 structures have been wiped out, according to the fire protection agency Cal Fire. Cal Fire officials said the Thomas Fire was 30 percent contained as of late Wednesday. Some residents have been allowed back in their ho...
Source: Asbestos and Mesothelioma News - December 15, 2017 Category: Environmental Health Authors: Daniel King Tags: Air Pollution Control District asbestos exposure Cal Fire California Department of Toxic Substances Control Charles Conway Karen Relucio Napa County Richard Belkin Ridley-Tree Cancer Center Santa Barbara County Sonoma County Thomas F Source Type: news

Edoxaban Noninferior to Dalteparin for Cancer-Associated VTE
The oral anticoagulant edoxaban appears noninferior to subcutaneous dalteparin for managing venous thromboembolism (VTE) in adults with cancer, according to an industry-supported, noninferiority trial... (Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - December 13, 2017 Category: Primary Care Source Type: news

Oral Edoxaban a New Alternative for VTE in Cancer Patients? Oral Edoxaban a New Alternative for VTE in Cancer Patients?
Edoxaban is on its way to becoming a new standard of care for cancer-associated venous thromboembolism (VTE), having shown noninferiority to dalteparin in a large randomized trial.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - December 12, 2017 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

New study finds smokeless tobacco causes mouth cancer, with more than half off all cases occurring in Asia
One thing you can rely on about tobacco: It’s bound to give you cancer if you put it in your body. Most of you may think that statement only applies to smoking tobacco. However, a study in Myanmar puts chewing tobacco in the same category. A recent study has discovered that almost all cases of mouth cancer... (Source: NaturalNews.com)
Source: NaturalNews.com - December 12, 2017 Category: Consumer Health News Source Type: news

Gum disease increases women's risk of breast cancer
Researchers from the University of Santa Maria in Brazil believe the bacteria that cause mouth inflammation enter the circulation via the gums where they go into breast tissue and cause tumours. (Source: the Mail online | Health)
Source: the Mail online | Health - December 7, 2017 Category: Consumer Health News Source Type: news

New Study Reinforces Link Between Birth Control & Breast Cancer Risk
By Meera Senthilingam, CNN (CNN) — Birth control can increase a woman’s risk of breast cancer by up to 38%, depending on how long she has taken it, a new study finds. The risk was associated with all forms of hormonal contraception — such as the pill, injections or IUDs — when compared with women who have never used them. Researchers from the University of Copenhagen analyzed data from 1.8 million women under the age of 50 in Denmark. They followed the women for nearly 11 years, on average. The level of breast cancer risk increased the longer a woman had been taking hormonal contraceptives, with the...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - December 7, 2017 Category: Consumer Health News Authors: Health – CBS Boston Tags: Health News birth control Breast Cancer Source Type: news

New Data To Be Presented At ASH 2017 Underscore Amgen's Commitment To Improving Lives And Changing Outcomes For Patients With Difficult-To-Treat Blood Cancers
Positive Overall Survival Data From Phase 3 ASPIRE Trial on KYPROLIS® (Carfilzomib) in Relapsed Multiple Myeloma to be Highlighted in Oral Presentation Results From Several Abstracts Highlight the Potential of Amgen's Bispecific T Cell Engager (BiTE®) Platform as an Innovative Approach to Treating Blood Cancers FDA Grants Priority Review for BLINCYTO (Blinatumomab) Supplemental Biologics License Application in Minimal Residual Disease-Positive Acute Lymphoblastic Leukemia THOUSAND OAKS, Calif., Dec. 7, 2017 /PRNewswire/ -- Amgen (NASDAQ:AMGN) today announced that new clinical data and analyses from 33...
Source: Amgen News Release - December 7, 2017 Category: Pharmaceuticals Tags: Uncategorized Source Type: news

All forms of hormonal contraception up breast cancer risk
A study led by the University of Aberdeen found the combined pill and progestogen-only pill have same risk, as do non-oral products such as the hormone-intrauterine system (IUS). (Source: the Mail online | Health)
Source: the Mail online | Health - December 7, 2017 Category: Consumer Health News Source Type: news

SABCS: I-SPY 3-year pCR results are powerful predictor for breast cancer survival
(King + Company) I-SPY TRIAL for Breast Cancer shows pathological complete response (pCR) predicts event-free/disease-free survival: Findings presented in Oral Presentation at San Antonio Breast Cancer Symposium today by Douglas Yee, MD for Quantum Leap Healthcare Collaborative. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - December 7, 2017 Category: Cancer & Oncology Source Type: news

Researchers make important bacterial discovery in oral pre-cancer condition
(Trinity College Dublin) Scientists at the School of Dental Science in Trinity have made an important discovery involving bacteria and a pre-cancerous growth called oral leuoplakia which can precede oral cancer. The researchers examined the microbiome of oral leukoplakia in order to determine if certain bacteria were associated with oral leukoplakia and whether the type of bacteria could predict whether these condition become malignant. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - December 7, 2017 Category: Cancer & Oncology Source Type: news

Small risk of breast cancer seen with hormone contraceptives
Modern low-dose birth control pills, available since the 1990s, have fewer side effects than the earliest oral contraceptives (Source: ABC News: Health)
Source: ABC News: Health - December 6, 2017 Category: Consumer Health News Tags: Health Source Type: news

Does Birth Control Use Up Breast Cancer Risk? (CME/CE)
(MedPage Today) -- Risk higher for certain oral contraceptives, but absolute risk was small (Source: MedPage Today Endocrinology)
Source: MedPage Today Endocrinology - December 6, 2017 Category: Endocrinology Source Type: news

Some Oral Bacteria Tied to Esophageal Cancer Risk Some Oral Bacteria Tied to Esophageal Cancer Risk
Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - December 6, 2017 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

Medical News Today: Mouth bacteria linked to esophageal cancer
New research reveals that some types of mouth bacteria are linked to higher risk of developing esophageal cancer and some are linked to lower risk. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - December 1, 2017 Category: Consumer Health News Tags: Cancer / Oncology Source Type: news

Gum Disease Tied to Yet Another Deadly Illness
FRIDAY, Dec. 1, 2017 -- Add one more reason to why you should brush and floss regularly: Gum disease bacteria are now tied to higher odds of esophageal cancer. The study tracked the oral health of 122,000 Americans for 10 years. It found that the... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - December 1, 2017 Category: General Medicine Source Type: news

Oral microbiota indicates link between periodontal disease and esophageal cancer
(American Association for Cancer Research) An analysis of bacteria present in the mouth showed that some types of bacteria that lead to periodontal disease were associated with higher risk of esophageal cancer. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - December 1, 2017 Category: International Medicine & Public Health Source Type: news

NIDCR Science News
Having trouble viewing this email? View it as a Web page. Why Head and Face Pain Causes More Suffering​  Duke University • November 13, 2017​​​ Pitt Study Provides Clues to Body's Defense Against Common Oral Ailment University of Pittsburgh • November 3, 2017​ Risk for Developing HPV-Related Throat Cancer Low​ Johns Hopkins University • October 20, 2017​ Mechanisms of Age-Related Bone Loss​University of Alabama at Birmingham...
Source: NIDCR Science News - November 30, 2017 Category: Dentistry Source Type: news

Question Relevant to All Oncologists Answered at ASH 2017 Question Relevant to All Oncologists Answered at ASH 2017
Cancer patients are at higher risk for venous thromboembolism. To date, the standard treatment has been subcutaneous low-molecular-weight heparin products, but now there are data on newer oral agents.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - November 30, 2017 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

Men are more than twice as to develop oral cancer
Toolkit for GPs has been produced to help tackle rising rates Related items fromOnMedica Sentinel node biopsy first to check spread of oral cancer Get tough on curbing children ’s poor dental health, government urged Mouth cancer Rates of mouth cancer rising sharply (Source: OnMedica Latest News)
Source: OnMedica Latest News - November 29, 2017 Category: UK Health Source Type: news

Increased oral pathogens, decreased bacterial diversity predict precancerous stomach cancer lesions
(New York University) Elevated pathogen colonization and a lack of bacterial diversity in the mouth were identified in people with precancerous lesions that could precede stomach cancer, finds a new study led by New York University College of Dentistry and New York University School of Medicine. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - November 27, 2017 Category: Cancer & Oncology Source Type: news

Test to calculate oral sex risk
More than three in four adults do not consider themselves at risk of mouth cancer, found a Oral Health Foundation survey. There are 7,500 UK cases each year – a rise of 68% in 20 years. (Source: the Mail online | Health)
Source: the Mail online | Health - November 24, 2017 Category: Consumer Health News Source Type: news

Medical News Today: Blood blister in mouth: Pictures and treatment
Learn about the causes of blood blisters in the mouth, including injury, oral herpes, stress, and oral cancer. How are blood blisters treated? (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 22, 2017 Category: Consumer Health News Tags: Dentistry Source Type: news

Study finds all Myanmar mouth cancer patients chew betel quid
(European Society for Medical Oncology) A study in Myanmar has found that all mouth cancer patients use smokeless tobacco, researchers report at the ESMO Asia 2017 Congress. Betel quid chewing often starts in adolescence and is associated with smoking and drinking alcohol, which are also risk factors for oral cancer. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - November 18, 2017 Category: Cancer & Oncology Source Type: news

Cancer symptoms: These THREE types are on the rise - do YOU know the signs?
CANCER survival rates are improving but rates of certain cancers are increasing. Do you know the symptoms of skin, ovarian and mouth cancers? (Source: Daily Express - Health)
Source: Daily Express - Health - November 11, 2017 Category: Consumer Health News Source Type: news

Health Tip: Recognize Symptoms of Oral Cancer
(Source: Cancercompass News: Other Cancer)
Source: Cancercompass News: Other Cancer - November 11, 2017 Category: Cancer & Oncology Source Type: news

Health Tip: Recognize Symptoms of Oral Cancer
-- Oral cancer typically is diagnosed between the ages of 55 and 64. It tends to affect more men than women, and will make up about 3 percent of all cancers diagnosed in 2017. The American Dental Association says symptoms of oral cancer may... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - November 10, 2017 Category: General Medicine Source Type: news