Differential effects of intensity and response preparation components of acoustic warning signals - Cappucci P, Correa, Guerra P, Lupi áñez J.
It is known that the increase of intensity on a warning signal (WS) usually decreases reaction times to targets and occasionally is accompanied by a startle reflex reaction that influences the speediness of response execution. In a simple detection task (E... (Source: SafetyLit)
Source: SafetyLit - March 11, 2019 Category: International Medicine & Public Health Tags: Egress, Escape, Evacuation, Crowds Source Type: news

Scientists find method to boost CRISPR efficiency
(UT Southwestern Medical Center) Scientists have developed a method to boost the efficiency of CRISPR gene editing in Duchenne muscular dystrophy (DMD), according to a study that could have implications for optimizing gene therapies for other diseases. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 6, 2019 Category: International Medicine & Public Health Source Type: news

PET, fMRI shed light on alcohol's effects on brain
Data from a combination of FDG-PET and functional MRI (fMRI) scans revealed...Read more on AuntMinnie.comRelated Reading: DTI-MRI shows drinking affects young men and women differently fMRI shows what makes an angry drunk PET, fMRI find beer reflex in brain SNMMI: PET/CT uncovers adaptations in alcoholic brain PET exposes shift in brain function among young alcohol abusers (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - March 4, 2019 Category: Radiology Source Type: news

Medical News Today: Pollutants may speed up ALS progression
New research suggests that environmental pollution, in general, and pesticides, in particular, may advance disease progression in people with ALS. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - March 2, 2019 Category: Consumer Health News Tags: Muscular Dystrophy / ALS Source Type: news

Chinese martial art training failed to improve balance or inhibit falls in older adults - Ma AWW, Wang HK, Chen DR, Chen YM, Chak YTC, Chan JWY, Yam TTT, Cheng YTY, Ganesan B, Fong SSM.
This randomized controlled trial explored the effects of a Ving Tsun (VT) Chinese martial art training program on reactive standing balance performance, postural muscle reflex contraction latency, leg muscle performance, balance confidence and falls in com... (Source: SafetyLit)
Source: SafetyLit - February 28, 2019 Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news

Medical News Today: ALS: New technique prevents toxic protein deposits in cells
Clumps of faulty TDP-43 protein inside nerve cells are common in ALS and other neurological diseases. Could this new technique offer a way to prevent them? (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - February 27, 2019 Category: Consumer Health News Tags: Muscular Dystrophy / ALS Source Type: news

Grant Marks Two Decades of NIH Support for Muscular Dystrophy Research
The University of Rochester Medical Center has received $8 million from the National Institutes of Health to support pioneering research on muscular dystrophy. The grant, which is a renewal of URMC ’s Paul D. Wellstone Muscular Dystrophy Cooperative Research Center, will fund ongoing work to investigate the genetic mechanisms and progression of this complex multi-system disease, research that has led scientists to the threshold of potential new therapies for myotonic dystrophy. (Source: University of Rochester Medical Center Press Releases)
Source: University of Rochester Medical Center Press Releases - February 25, 2019 Category: Universities & Medical Training Authors: University of Rochester Medical Center Source Type: news

Thermography Is Not an Alternative for Mammography, FDA Warns
FDA is alerting women, healthcare providers, and others getting breast cancer screening that thermography is not an effective alternative to mammography and should not be used in place of mammography for breast cancer screening or diagnosis. The agency said there is no valid scientific data to demonstrate that thermography devices, when used on their own or with another diagnostic test, are an effective screening tool for any medical condition, including the early detection of breast cancer or other diseases and health conditions. Mammography, which involves taking X-rays of the breasts, is the most effective breast cancer...
Source: MDDI - February 25, 2019 Category: Medical Devices Authors: Amanda Pedersen Tags: Regulatory and Compliance Imaging Source Type: news

New drug for Duchenne muscular dystrophy clears phase 1 clinical trial
Patients with Duchenne muscular dystrophy (DMD) have few treatment options. Medications currently available or in development either target only a subset of DMD patients with a particular genetic mutation or cause significant side effects. The investigational drug edasalonexent, an oral NF-κB inhibitor, has the potential to slow the progression of the disease for all patients with DMD. (Source: World Pharma News)
Source: World Pharma News - February 21, 2019 Category: Pharmaceuticals Tags: Featured Research Research and Development Source Type: news

New drug for Duchenne muscular dystrophy clears phase 1 clinical trial testing in boys
(IOS Press) Patients with Duchenne muscular dystrophy (DMD) have few treatment options. Medications currently available or in development either target only a subset of DMD patients with a particular genetic mutation or cause significant side effects. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 21, 2019 Category: International Medicine & Public Health Source Type: news

Sales of Philadelphia-born gene therapy product hit $27M during first year
In its first year, Luxturna — the first Food and Drug Administrative-approved gene therapy treatment for an inherited disease — generated $27 million in sales for Philadelphia-based Spark Therapeutics. Spark said it has shipped 75 vials of Luxturna, a one-time gene therapy used to treat adult and pediatric patients with v ision loss caused by inherited retinal dystrophy from a genetic mutation. The inherited retinal disorder, which leads to blindness if untreated, afflicts an estimated 1,000… (Source: bizjournals.com Health Care:Physician Practices headlines)
Source: bizjournals.com Health Care:Physician Practices headlines - February 19, 2019 Category: American Health Authors: John George Source Type: news

Single CRISPR treatment provides long-term benefits in mice
(Duke University) Researchers at Duke University have shown that a single systemic treatment using CRISPR genome editing technology can safely and stably correct a genetic disease -- Duchenne muscular dystrophy (DMD) -- for more than a year in mice, despite observed immune responses and alternative gene editing outcomes. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 18, 2019 Category: International Medicine & Public Health Source Type: news

Sarepta Announces FDA Acceptance of Golodirsen (SRP-4053) New Drug Application for Patients with Duchenne Muscular Dystrophy Amenable to Skipping Exon 53
CAMBRIDGE, Mass., Feb. 14, 2019 (GLOBE NEWSWIRE) -- Sarepta Therapeutics, Inc. (NASDAQ:SRPT), the leader in precision genetic medicine for rare diseases, announced the Food and Drug Administration, Division of Neurology (the Division), has accepted... (Source: Drugs.com - New Drug Applications)
Source: Drugs.com - New Drug Applications - February 14, 2019 Category: Drugs & Pharmacology Source Type: news

UMN study provides new insight into use of cell replacement therapies to treat muscular dystrophies
(University of Minnesota Medical School) The University of Minnesota Medical School continues its legacy of advancing cell replacement therapies with a scientific breakthrough that highlights the promise of cell therapies for muscular dystrophy. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 13, 2019 Category: International Medicine & Public Health Source Type: news

URMC Designated as a Duchenne Care Center
Parent Project Muscular Dystrophy, a nonprofit organization dedicated to advancing care and research for patients with Duchenne muscular dystrophy, has named the University of Rochester Medical Center a Certified Duchenne Care Center. This program of leading centers, created in 2014 by PPMD, reviews and recognizes clinics nationwide for their outstanding neuromuscular programs. (Source: University of Rochester Medical Center Press Releases)
Source: University of Rochester Medical Center Press Releases - February 12, 2019 Category: Universities & Medical Training Authors: University of Rochester Medical Center Source Type: news

Jeff Bezos protests the invasion of his privacy, as Amazon builds a sprawling surveillance state for everyone else
(Natural News) THE NATIONAL ENQUIRER HAS engaged in behavior so lowly and unscrupulous that it created a seemingly impossible storyline: the world’s richest billionaire and a notorious labor abuser, Amazon CEO Jeff Bezos, as a sympathetic victim. (Article by Glenn Greenwald republished from TheIntercept.com) On Thursday, Bezos published emails in which the Enquirer’s parent company explicitly threatened to publish intimate photographs... (Source: NaturalNews.com)
Source: NaturalNews.com - February 11, 2019 Category: Consumer Health News Source Type: news

Music therapy program at UCLA aims to help premature infants develop feeding skills
It ’s a Friday morning in January when Jana Gallus, 32, and Gregor Martynus, 35, peek their heads over their triplets’ set of bassinets in their Westwood apartment. Six-month-olds Ada, Kian and Nico are just waking up, kicking with excitement and beaming from ear to ear.It ’s a daily moment that Gallus and Martynus say doesn’t get old. The triplets have come a long way since July, when they were born early, at 31 weeks, with weights ranging from 2.5 to 4 pounds. For 52 days, the trio were cared for in the neonatal intensive care unit, or NICU, atUCLA Mattel Children ’s Hospital.As the UCLA tea...
Source: UCLA Newsroom: Health Sciences - February 11, 2019 Category: Universities & Medical Training Source Type: news

New research insights hold promise for kids with DMD
(Children's National Health System) Prednisone, the current standard of care used to treat kids with Duchenne muscular dystrophy (DMD), reduces chronic inflammation but has harsh side effects. Eplerenone, a heart failure drug, is used in older patients to treat cardiomyopathy, a leading cause of mortality for people with DMD. A new medicine under development appears to combine the beneficial effects of these drugs for the heart and muscle while also showing improved safety in experimental models. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 11, 2019 Category: International Medicine & Public Health Source Type: news

Book Review: Clinical Applications of the Polyvagal Theory
Clinical Applications of the Polyvagal Theory is another work in the Norton series on interpersonal neurobiology. I have come to believe that at least three theories are indispensable in learning and understanding how and why we behave the way we do — attribution theory, attachment theory, and our underlying physiology of safety, called the polyvagal theory. The polyvagal theory was developed by Stephen Porges and presented to the Society for Psychophysiological Research in 1994. The theory takes into account how our autonomic nervous system is constantly working to keep us safe. Very simply, the components are our ...
Source: Psych Central - February 4, 2019 Category: Psychiatry Authors: Stan Rockwell, PsyD Tags: Anxiety Book Reviews Disorders General Memory and Perception Mindfulness Neuroscience Panic Disorder Personal Stories Psychological Assessment Psychology Psychotherapy PTSD Relationships & Love Relaxation and Meditation Traum Source Type: news

Exercise-induced alterations in sympathetic-somatomotor coupling in incomplete spinal cord injury - Onushko T, Mahtani G, Brazg G, Hornby TG, Schmit BD.
The purpose of this study was to understand how high and low intensity locomotor training (LT) affects sympathetic-somatomotor coupling in people with incomplete spinal cord injury (SCI). Proper coupling between sympathetic and somatomotor systems allows c... (Source: SafetyLit)
Source: SafetyLit - February 4, 2019 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news

UNISON branch treasurer ’ s determination wins fair pay for college staff
A library assistant and UNISON branch treasurer has won another victory in the union’s battle to ensure that its term-time members in education are being paid their due. Julie Robinson discovered that the term-time staff at Solihull Sixth Form College were receiving no payment in respect of public holidays, as they were entitled. Those affected included admin staff, careers advisors, science and art technicians and, like herself, Learning Resource Centre staff. The payments concern those Bank Holidays and other concessionary days that fall outside of the school or college term. In contrast to Ms Robinson and her coll...
Source: UNISON Health care news - February 1, 2019 Category: UK Health Authors: Demetrios Matheou Tags: Article News education higher education pay West Midlands Source Type: news

Discovery points to innovative new way to treat Duchenne muscular dystrophy
(The Ottawa Hospital) Researchers at The Ottawa Hospital and the University of Ottawa have discovered a new way to treat the loss of muscle function caused by Duchenne muscular dystrophy in animal models of the disease. As reported in Cell Stem Cell, the team restored muscle stem cell function that is impaired in Duchenne muscular dystrophy, resulting in efficient regeneration of the muscle and preventing the progressive loss of muscle strength characteristic of the disease. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - January 31, 2019 Category: International Medicine & Public Health Source Type: news

Heart rate variability and performance of commercial airline pilots during flight simulations - Cao X, MacNaughton P, Cadet LR, Cedeno-Laurent JG, Flanigan S, Vallarino J, Donnelly-McLay D, Christiani DC, Spengler JD, Allen JG.
Pilots undergo a variety of stressors that may affect their performance during all phases of flight. Heart rate variability (HRV) has been considered as a reliable indicator of the parasympathetic and sympathetic activities of human autonomic nervous syste... (Source: SafetyLit)
Source: SafetyLit - January 22, 2019 Category: International Medicine & Public Health Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news

Medical News Today: ALS: A new therapy may be in sight
New research, led by Harvard scientists, identifies a novel potential therapeutic target for treating amyotrophic lateral sclerosis (ALS). (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - January 17, 2019 Category: Consumer Health News Tags: Muscular Dystrophy / ALS Source Type: news

Muscle stem cells can drive cancer that arises in Duchenne muscular dystrophy
People with Duchenne muscular dystrophy (DMD) can develop an otherwise-rare muscle cancer, called rhabdomyosarcoma, due to the muscle cells' continuous work to rebuild the damaged tissue. However, little is known about how the cancer arises, hindering development of a treatment or test that could predict cancer risk. (Source: World Pharma News)
Source: World Pharma News - January 15, 2019 Category: Pharmaceuticals Tags: Featured Research Research and Development Source Type: news

Muscle stem cells can drive cancer that arises in Duchenne muscular dystrophy
(Sanford Burnham Prebys Medical Discovery Institute) Scientists from Sanford Burnham Prebys Medical Discovery Institute (SBP) have demonstrated that muscle stem cells may give rise to rhabdomyosarcoma that occurs during DMD--and identified two genes linked to the tumor's growth. The research, performed using a mouse model of severe DMD, helps scientists better understand how rhabdomyosarcoma develops in DMD--and indicates that ongoing efforts to develop treatments that stimulate muscle stem cells should consider potential cancer risk. The study was published in Cell Reports on January 15, 2019. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - January 15, 2019 Category: Cancer & Oncology Source Type: news

Poor Sleep Linked To Dangerous Plaque Buildup In Arteries
By Sandee LaMotte, CNN (CNN) — Here’s another reason why getting a good night’s sleep should be on your must-do list: Sleeping fewer than six hours a night or waking frequently raises your risk of developing damaging plaque in arteries throughout your body, not just your heart. Previous research has shown poor sleep to be strongly associated with coronary heart disease, but “This is the first study to show that objectively measured sleep is independently associated with atherosclerosis throughout the body,” José Ordovás, director of nutrition and genomics at the Jean Mayer USDA H...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - January 14, 2019 Category: Consumer Health News Authors: Health – CBS Boston Tags: Boston News Health CNN Heart Disease Sleep Tufts University Source Type: news

The dangers of sneezing: a review of injuries - Setzen S, Platt M.
BACKGROUND: Sneezing is an almost universal daily phenomenon as a reflex to evacuate irritants from the nasal cavities. An autonomic-controlled buildup of intrathoracic pressure against a closed glottis followed by sudden release results in a burst of 1 kP... (Source: SafetyLit)
Source: SafetyLit - January 10, 2019 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news

Researchers overcome hurdle in CRISPR gene editing for muscular dystrophy
(University of Missouri-Columbia) The gene editing technique known as CRISPR is a revolutionary approach to treating inherited diseases. However, the tool has yet to be used to effectively treat long-term, chronic conditions. A research team led by Dongsheng Duan, PhD, at the University of Missouri School of Medicine has identified and overcome a barrier in CRISPR gene editing that may lay the foundation for sustained treatments using the technique. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 8, 2019 Category: International Medicine & Public Health Source Type: news

U.S. Supreme Court could side with Merck over Fosamax lawsuits
U.S. Supreme Court justices on Monday appeared sympathetic to Merck& Co in its bid to fend off hundreds of lawsuits accusing the company of failing to adequately warn patients of the risks of thigh bone fractures associated with its osteoporosis drug Fosamax. (Source: Reuters: Health)
Source: Reuters: Health - January 7, 2019 Category: Consumer Health News Tags: healthNews Source Type: news

Home Monitoring of Lung Function Feasible in Teens With Duchenne
MONDAY, Jan. 7, 2019 -- In adolescent patients with Duchenne muscular dystrophy (DMD), use of a handheld device (HHD) to assess pulmonary function at home is feasible and provides reliable data, according to an analysis recently published in the... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - January 7, 2019 Category: Pharmaceuticals Source Type: news

Is Ablative Solutions ’ Latest Financing a Positive Sign for Renal Denervation?
Ablative Solutions latest financing might have just significantly improved investor faith in renal denervation procedures for the treatment of uncontrolled hypertension. The Kalamazoo, MI-based company revealed the first close of its $77 million series D round, which will be used to get its Peregrine System kit through regulatory trials. The firm’s device is a minimally invasive renal denervation technology designed to help reduce blood pressure for people with uncontrolled hypertension, while taking antihypertensive medication. The Peregrine System kit is engineered to target nerves known to influence th...
Source: MDDI - January 3, 2019 Category: Medical Devices Authors: Omar Ford Tags: Cardiovascular Source Type: news

An Experimental Procedure Could Help More Families Have Healthy Babies. But It ’s Not Allowed in the U.S.
When Noah Shulman was born a few days after Christmas 2016, his parents Kristelle and Evan had no reason to worry about him. The pregnancy went smoothly, and so did the birth. But within a few days of taking his first breath, Noah began to struggle. He wasn’t feeding, so he started losing weight. He was also lethargic. Several pediatricians reassured the Shulmans that they were probably just overly sensitive to Noah’s symptoms because Kristelle is a nurse and Evan is a physician assistant–a case of first-time-parent-white-coat syndrome. “They kind of dismissed us as neurotic parents,” says Eva...
Source: TIME: Science - January 3, 2019 Category: Science Authors: Alice Park Tags: Uncategorized fertility Research Source Type: news

An Experimental Procedure Could Help More Families Have Healthy Babies. But It ’s Not Allowed in the U.S.
When Noah Shulman was born a few days after Christmas 2016, his parents Kristelle and Evan had no reason to worry about him. The pregnancy went smoothly, and so did the birth. But within a few days of taking his first breath, Noah began to struggle. He wasn’t feeding, so he started losing weight. He was also lethargic. Several pediatricians reassured the Shulmans that they were probably just overly sensitive to Noah’s symptoms because Kristelle is a nurse and Evan is a physician assistant–a case of first-time-parent-white-coat syndrome. “They kind of dismissed us as neurotic parents,” says Eva...
Source: TIME: Health - January 3, 2019 Category: Consumer Health News Authors: Alice Park Tags: Uncategorized fertility Research Source Type: news

U.S. Drug Developer Capricor Places Duchenne Drug Trial on Hold U.S. Drug Developer Capricor Places Duchenne Drug Trial on Hold
Capricor Therapeutics Inc said on Wednesday it had put on hold a clinical trial of its drug to treat Duchenne muscular dystrophy (DMD), a muscle-wasting disorder, citing a safety review.Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - December 28, 2018 Category: Consumer Health News Tags: Family Medicine/Primary Care News Source Type: news

Company halts drug trial for rare disease
Capricor Therapeutics has announced that it is stopping progress on a trial for a new Duchenne muscular dystrophy treatment. (Source: PharmaManufacturing.com)
Source: PharmaManufacturing.com - December 27, 2018 Category: Pharmaceuticals Source Type: news

U.S. drug developer Capricor places Duchenne drug trial on hold
Capricor Therapeutics Inc said on Wednesday it had put on hold a clinical trial of its drug to treat Duchenne muscular dystrophy (DMD), a muscle-wasting disorder, citing a safety review. (Source: Reuters: Health)
Source: Reuters: Health - December 26, 2018 Category: Consumer Health News Tags: healthNews Source Type: news

Capricor places Duchenne drug trial on hold
Capricor Therapeutics Inc said on Wednesday it had put on hold a clinical trial of its drug to treat Duchenne muscular dystrophy, a muscle-wasting disorder. (Source: Reuters: Health)
Source: Reuters: Health - December 26, 2018 Category: Consumer Health News Tags: healthNews Source Type: news

Sarepta Therapeutics Completes Submission of New Drug Application Seeking Approval of Golodirsen (SRP-4053) in Patients with Duchenne Muscular Dystrophy Amenable to Skipping Exon 53
CAMBRIDGE, Mass., Dec. 20, 2018 (GLOBE NEWSWIRE) -- Sarepta Therapeutics, Inc. (NASDAQ:SRPT), a leader in precision genetic medicine for rare diseases, announced today that it has completed the submission of its rolling New Drug Application (NDA)... (Source: Drugs.com - New Drug Applications)
Source: Drugs.com - New Drug Applications - December 20, 2018 Category: Drugs & Pharmacology Source Type: news

Monitoring lung function at home in teens with Duchenne muscular dystrophy
(IOS Press) Heart and lung complications are responsible for much of the morbidity and mortality associated with Duchenne muscular dystrophy (DMD). Although regular monitoring of pulmonary function is recommended in order to detect deterioration, compliance with routine testing, such as hospital-based spirometry, is frequently poor. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - December 17, 2018 Category: International Medicine & Public Health Source Type: news

The gaze stabilization test following concussion - Dunlap PM, Mucha A, Smithnosky D, Whitney SL, Furman JM, Collins MW, Kontos AP, Sparto PJ.
BACKGROUND: Concussion can cause vestibular dysfunction and oculomotor abnormalities which can lead to dizziness and protracted recovery time. There are few clinically useful, functional measures of the vestibulo-ocular reflex (VOR) post-concussion. ... (Source: SafetyLit)
Source: SafetyLit - December 16, 2018 Category: International Medicine & Public Health Tags: TBI Source Type: news

New mouse model may speed identification of promising muscular dystrophy therapies
(Massachusetts General Hospital) A Massachusetts General Hospital research team has created a new mouse model of a common form of muscular dystrophy with the potential of rapidly distinguishing promising therapeutic drugs from those unlikely to be successful. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - December 12, 2018 Category: International Medicine & Public Health Source Type: news

UMN researchers give new insight to muscular dystrophy patients
(University of Minnesota Medical School) New research by University of Minnesota scientists has revealed the three dimensional structure of the DUX4 protein, which is responsible for the disease, facioscapulohumeral muscular dystrophy (FSHD). Unlike the majority of genetic diseases, FSHD is not caused by a protein that is missing or not functioning properly. Rather it is caused when a functioning, normal, protein shows up in a place where it doesn't belong (in muscles). (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - December 12, 2018 Category: International Medicine & Public Health Source Type: news

Can We Ever Be Truly Fearless?
We ’ ve needed fear to survive as a species. But how do you not let the emotional response of the fear reflex run wild? (Source: NYT Health)
Source: NYT Health - December 11, 2018 Category: Consumer Health News Authors: JUDI KETTELER Tags: Fear (Emotion) Post-Traumatic Stress Disorder Psychology and Psychologists Source Type: news

Fear of sleep may be a core symptom of sympathetic activation and the drive for vigilance in posttraumatic stress disorder - Gupta MA, Sheridan AD.
[Abstract unavailable] Language: en... (Source: SafetyLit)
Source: SafetyLit - December 10, 2018 Category: International Medicine & Public Health Tags: Distraction, Fatigue, Chronobiology, Vigilance, Workload Source Type: news

A mechanistic classification of clinical phenotypes in neuroblastoma
Neuroblastoma is a pediatric tumor of the sympathetic nervous system. Its clinical course ranges from spontaneous tumor regression to fatal progression. To investigate the molecular features of the divergent tumor subtypes, we performed genome sequencing on 416 pretreatment neuroblastomas and assessed telomere maintenance mechanisms in 208 of these tumors. We found that patients whose tumors lacked telomere maintenance mechanisms had an excellent prognosis, whereas the prognosis of patients whose tumors harbored telomere maintenance mechanisms was substantially worse. Survival rates were lowest for neuroblastoma patients w...
Source: ScienceNOW - December 6, 2018 Category: Science Authors: Ackermann, S., Cartolano, M., Hero, B., Welte, A., Kahlert, Y., Roderwieser, A., Bartenhagen, C., Walter, E., Gecht, J., Kerschke, L., Volland, R., Menon, R., Heuckmann, J. M., Gartlgruber, M., Hartlieb, S., Henrich, K.-O., Okonechnikov, K., Altmü Tags: Medicine, Diseases reports Source Type: news

Early stage neural device dev Tulavi Therapeutics raises $3m
Early stage medical device developer Tulavi Therapeutics has raised approximately $3 million in a new round of equity financing, according to recently posted SEC filings. Tulavi Therapeutics is developing a medical device-based therapy intended to prevent or treat aberrant neural reflex arcs in peripheral and visceral disease. The technology is intended for use through both surgical and interventional approaches, according to the company’s website. The company is being led by former Reflex Medical founder & CEO Corinne Bright. Money in the round comes from three anonymous investors with the first sale dated on Ap...
Source: Mass Device - December 4, 2018 Category: Medical Devices Authors: Fink Densford Tags: Business/Financial News Neurological tulavitherapeutics Source Type: news

Paroxysmal sympathetic hyperactivity after severe traumatic brain injury in children: prevalence, risk factors, and outcome - Alofisan TO, Algarni YA, Alharfi IM, Miller MR, Charyk Stewart T, Fraser DD, Tijssen JA.
OBJECTIVE: To describe paroxysmal sympathetic hyperactivity in pediatric patients with severe traumatic brain injury using the new consensus definition, the risk factors associated with developing paroxysmal sympathetic hyperactivity, and the outcomes asso... (Source: SafetyLit)
Source: SafetyLit - December 3, 2018 Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news

EMedHome's Clinical Pearl: The Reflex and the Bradycardia
No abstract available (Source: Emergency Medicine News)
Source: Emergency Medicine News - December 1, 2018 Category: Emergency Medicine Tags: EMedHome's Clinical Pearl Source Type: news

Tragedy of boy, 2, suffering from rare childhood 'Parkinson's mixed with Alzheimer's' disease
L éo Vauclare, from Paris, France, was diagnosed with Infantile Neuroaxonal Dystrophy in June. The disease will rob him of his speech and mobility - and kill him before he's a teenager. (Source: the Mail online | Health)
Source: the Mail online | Health - November 27, 2018 Category: Consumer Health News Source Type: news