New data for Roche ’s OCREVUS (ocrelizumab) reinforce significant benefit on slowing disease progression in relapsing and primary progressive multiple sclerosis
Basel, 16 April 2021 - Roche (SIX: RO, ROG; OTCQX: RHHBY) today announced new OCREVUS ® (ocrelizumab) analyses supporting its significant benefit on disease progression in early-stage relapsing-remitting multiple sclerosis (RRMS) and primary progressive MS (PPMS) as well as demonstrating high persistence and strong adherence to twice-yearly (six-monthly) dosing. These data are being presented virtually at the 73rd American Academy of Neurology (AAN) Annual Meeting from 17–22 April 2021. OCREVUS is the number one prescribed MS medication in the U.S. for patients starting a new treatment, and more than 200,000 peop...
Source: Roche Investor Update - April 16, 2021 Category: Pharmaceuticals Source Type: news

Novel muscular dystrophy gene connects to a key biological pathway
(University of Minnesota Medical School) New research from the University of Minnesota Medical School found mutations in a novel gene that may help identify patients with a specific form of muscular dystrophy. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 15, 2021 Category: International Medicine & Public Health Source Type: news

New discovery could lead to therapies for patients with Duchenne muscular dystrophy
(University of California - Irvine) A new study, led by the University of California, Irvine (UCI), reveals how chronic inflammation promotes muscle fibrosis, which could inform the development of new therapies for patients suffering from Duchenne muscular dystrophy (DMD), a fatal muscle disease. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 14, 2021 Category: International Medicine & Public Health Source Type: news

Biotech company spun out of Ohio State University research raises $116M in latest round
A biotechnology company that spun out of Ohio State University research announced it raised more than $116 million in its latest financing round. Boston-based Entrada Therapeutics Inc., which was co-founded by an OSU professor, said the investment will support treating people with multiple neuromuscular diseases, including Duchenne muscular dystrophy. When it was founded in 2018, Entrada raised $59 million, which was the largest amount rai sed in an initial financing round for an OSU startup. The… (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - April 5, 2021 Category: Biotechnology Authors: Hayleigh Colombo Source Type: news

A psychophysiological model of firearms training in police officers: a virtual reality experiment for biocybernetic adaptation - Mu ñoz JE, Quintero L, Stephens CL, Pope AT.
Crucial elements for police firearms training include mastering very specific psychophysiological responses associated with controlled breathing while shooting. Under high-stress situations, the shooter is affected by responses of the sympathetic nervous s... (Source: SafetyLit)
Source: SafetyLit - April 4, 2021 Category: International Medicine & Public Health Tags: Occupational Issues Source Type: news

Heightened Brain Activity With Stress Tied to Takotsubo Syndrome Heightened Brain Activity With Stress Tied to Takotsubo Syndrome
A higher ratio of amygdalar to regulatory brain activity may lead to heightened response to stressors, activation of the sympathetic and immune systems, and risk for so-called'broken heart syndrome. 'Medscape Medical News (Source: Medscape Cardiology Headlines)
Source: Medscape Cardiology Headlines - March 29, 2021 Category: Cardiology Tags: Neurology & Neurosurgery News Source Type: news

Chemical cocktail creates new avenues for muscle stem cell therapies
A UCLA-led research team has identified a chemical cocktail that enables the production of large numbers of muscle stem cells, which can self-renew and give rise to all types of skeletal muscle cells.The advance could lead to the development of stem cell-based therapies for muscle loss or damage due to injury, age or disease.The research was published in Nature Biomedical Engineering.Muscle stem cells are responsible for muscle growth, repair and regeneration following injury throughout a person ’s life. In fully grown adults, muscle stem cells are quiescent — they remain inactive until they are called to respo...
Source: UCLA Newsroom: Health Sciences - March 18, 2021 Category: Universities & Medical Training Source Type: news

When depression wears a smile, even psychiatrists like me can be deceived | Rebecca Lawrence
By the time mental ill health is visible, it ’s probably very bad. The best risk assessment is to listen rather than lookIn my everyday life, when I see someone who looks happy, I expect them to feel like that, too. I don ’t think about it particularly – it’s a reflex. I glance casually at a smiling face and am reassured that all is well. It takes a conscious effort to remind myself of a fact that psychiatrists know very well on an intellectual level but should perhaps recognise more: a cheerful demeanour can b e profoundly misleading.The concept of the “happy” depressive is familiar in ...
Source: Guardian Unlimited Science - March 18, 2021 Category: Science Authors: Rebecca Lawrence Tags: Mental health UK news Depression Psychiatry Psychology Society Science Source Type: news

New two-year data show Roche ’s Evrysdi (risdiplam) continues to demonstrate improvement or maintenance of motor function in people aged 2-25 with Type 2 or Type 3 Spinal Muscular Atrophy (SMA)
Basel, 16 March 2021 - Roche (SIX: RO, ROG; OTCQX: RHHBY) today announced new exploratory 2-year longer-term data from Part 2 of SUNFISH, a global placebo-controlled study evaluating Evrysdi ™ (risdiplam) in people aged 2-25 years with Type 2 or non-ambulant Type 3 spinal muscular atrophy (SMA). The study suggests that gains in motor function observed with Evrysdi treatment at month 12 continued to improve or were maintained at month 24 across primary and secondary endpoint measures. Based on the natural history of the disease, people with Types 2 and 3 SMA who remain untreated decline in motor function over time. Th...
Source: Roche Investor Update - March 16, 2021 Category: Pharmaceuticals Source Type: news

New two-year data show Roche ’s Evrysdi (risdiplam) continues to demonstrate improvement or maintenance of motor function in people aged 2-25 with Type 2 or Type 3 Spinal Muscular Atrophy (SMA)
Basel, 16 March 2021 - Roche (SIX: RO, ROG; OTCQX: RHHBY) today announced new exploratory 2-year longer-term data from Part 2 of SUNFISH, a global placebo-controlled study evaluating Evrysdi ™ (risdiplam) in people aged 2-25 years with Type 2 or non-ambulant Type 3 spinal muscular atrophy (SMA). The study suggests that gains in motor function observed with Evrysdi treatment at month 12 continued to improve or were maintained at month 24 across primary and secondary endpoint measures. Based on the natural history of the disease, people with Types 2 and 3 SMA who remain untreated decline in motor function over time. Th...
Source: Roche Media News - March 16, 2021 Category: Pharmaceuticals Source Type: news

A rare trigger for photosensitive seizure: fireworks - G ürbüz G, Gürbüz B.
Reflex epilepsy is a type of epilepsy involving seizures that occur with sensory stimulus. It occurs when the cortical and subcortical brain areas over-react to a physiological stimulus. Stimulus can be simple like flickering lights, hot water or complex l... (Source: SafetyLit)
Source: SafetyLit - March 13, 2021 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news

An atypical presentation of sympathetic ophthalmia in an intact globe following mechanical fall: a case report and literature review - Chean CS, Lim CS, Kumar P, Kapoor B.
PURPOSE: To describe an atypical case of sympathetic ophthalmia presenting after blunt trauma causing disinsertion of the iris in an intact globe. METHODS: Case report. RESULTS: A 71-year-old lady presented to the Emergency Department follo... (Source: SafetyLit)
Source: SafetyLit - March 12, 2021 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news

Physician Support Line: One Psychiatrist Making a Difference Physician Support Line: One Psychiatrist Making a Difference
A Pennsylvania psychiatrist has started a peer-to-peer physician support hotline with psychiatrist volunteers providing a sympathetic ear.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - March 5, 2021 Category: Consumer Health News Tags: Psychiatry News Source Type: news

A new blindness gene uncovered in a canine study
(University of Helsinki) A study recently completed at the University of Helsinki has uncovered a mutation in the IFT122 gene in blind dogs. The gene defect now discovered results in the progressive destruction of photoreceptor cells and retinal dystrophy. IFT122 is a new candidate also for retinal dystrophy in humans. A gene test in support of breeding and diagnostics has been developed based on the finding. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 2, 2021 Category: International Medicine & Public Health Source Type: news

Translating passion into execution: Cure Rare Disease's founder on the business of biotech
When a career path chooses you in the form of a pressing personal cause, passion and commitment must soon be followed by execution. And that means schooling up — quickly. I had heard the call of entrepreneurship early. I had a new Harvard Business School degree in hand at the same time my brother’s health was declining steeply due to Duchenne muscular dystrophy. His fatal degenerative neuromuscular condition wouldn't wait, and the lack of viable option s in the pipeline for his gene mutation required entrepreneurial thinking. The science would come. I was in Boston, after all, immersed in bioscience. And it has...
Source: bizjournals.com Health Care:Biotechnology headlines - February 26, 2021 Category: Biotechnology Authors: Rich Horgan Source Type: news

FDA OKs First'Targeted Treatment' for Rare DMD Mutation FDA OKs First'Targeted Treatment' for Rare DMD Mutation
The FDA has approved casimersen (Amondys 45) injection for treating patients with both Duchenne muscular dystrophy (DMD) and a rare mutation of the DMD gene.FDA Approvals (Source: Medscape Pediatrics Headlines)
Source: Medscape Pediatrics Headlines - February 26, 2021 Category: Pediatrics Tags: Neurology & Neurosurgery News Alert Source Type: news

FDA Approves Amondys 45 (casimersen) Injection for the Treatment of Duchenne Muscular Dystrophy (DMD) in Patients Amenable to Skipping Exon 45
CAMBRIDGE, Mass., Feb. 25, 2021 (GLOBE NEWSWIRE) -- Sarepta Therapeutics, Inc. (NASDAQ:SRPT), the leader in precision genetic medicine for rare diseases, today announced that the U.S. Food and Drug Administration (FDA) has approved Amondys 45... (Source: Drugs.com - New Drug Approvals)
Source: Drugs.com - New Drug Approvals - February 25, 2021 Category: Drugs & Pharmacology Source Type: news

For UCLA-based startup, new muscular dystrophy treatment is a personal mission
Courtney Young helped develop the gene therapy at the heart of a biotech startup,MyoGene Bio, when she was a doctoral student at UCLA from 2013 to 2018. But the kernel of the company ’s endeavor is older still — and definitively personal.In 2008, when Young was in high school, she found out that her cousin, then just a toddler, had been diagnosed with Duchenne muscular dystrophy. She made it her mission to cultivate the skills needed to provide better options for him and others who were suffering with the deadly muscle-wasting disease.“I directed my career toward working on Duchenne,” said Young, My...
Source: UCLA Newsroom: Health Sciences - February 23, 2021 Category: Universities & Medical Training Source Type: news

After the Nobel, what next for Crispr  gene-editing therapies?
Hailed as the ‘molecular scissors’ that will allow us to rewrite our genes, the DNA tool is being trialled in treatments for everything from sickle-cell anaemia to cancerWhen last year ’s Nobel prize for chemistry was awarded tobiochemist Jennifer Doudna and microbiologist Emmanuelle Charpentier for their work in developing the technique of gene editing known as Crispr-Cas9 (pronounced “crisper”), headlines hailed their discovery as “molecular scissors” that would allow us to “rewrite the book of life” – with all the complicated ethical questions that ability rais...
Source: Guardian Unlimited Science - February 21, 2021 Category: Science Authors: Philip Ball Tags: Gene editing Medical research Genetics Biology Science Cancer Huntington's disease Sickle cell disease Source Type: news

Invitation to Roche ’s virtual event on 24-month data of Evrysdi in patients with type 2 or type 3 spinal muscular atrophy presented at the 2021 MDA virtual conference
We are pleased to invite investors and analysts to participate in our virtual event on Friday, 19 March, 2021, highlighting Roche data presented during the 2021 Muscular Dystrophy Association - MDA -Virtual Clinical and Scientific Conference, from 15th to 18th February. (Source: Roche Investor Update)
Source: Roche Investor Update - February 19, 2021 Category: Pharmaceuticals Source Type: news

Sir Peter Harper obituary
Researcher into the genetics of neurological disorders whose work has provided hope for a cure for muscular dystrophyPeter Harper, who has died aged 81, was a world expert on the genetics of inherited neurological disorders, particularlyHuntington ’s disease andmuscular dystrophy. He also advocated the idea of genetic counselling – helping people to understand the implications of inherited disorders that might affect them and their families.Finding a genetic link between the two wasting conditions has led to highly accurate diagnostic and predictive tests for at-risk individuals and their families. Peter played...
Source: Guardian Unlimited Science - February 15, 2021 Category: Science Authors: Peter McGuffin Tags: Genetics Medicine Science Education Biology Huntington's disease Source Type: news

New tests promise to improve sepsis diagnosis and treatment, MLO: Medical Laboratory Observer 53(2): 22-23
Sepsis represents the ultimate clinical ticking clock - given that patient mortality rates increase nearly 8 percent for each hour that appropriate treatment is delayed.1 Years ago, testing options for patients suspected of having bloodstream infections were limited to culture-based workflows, which take several days to deliver final results. Because these symptoms overlap with so many other health conditions, it is impossible to confirm a suspected diagnosis of sepsis without a lab test. In this stage, mortality rates climb to 40 percent, and patients who survive septic shock may develop lifelong complications from blood ...
Source: Current Awareness Service for Health (CASH) - February 11, 2021 Category: Consumer Health News Source Type: news

The Hardship of Social Distancing When Touch Is a Lifeline
For me, and many others with physical disabilities, touch is not merely a luxury or a pleasure, but an aspect of my functionality, my basic survival. (Source: NYT Health)
Source: NYT Health - February 10, 2021 Category: Consumer Health News Authors: Sonali Gupta Tags: Touch (Sense) Muscular Dystrophy Quarantines Muscles Genetics and Heredity Coronavirus (2019-nCoV) Physical Therapy Disabilities Source Type: news

A Glitch in the Matrix review – deep-dive into simulation theory
Using animation, archive and clips from the movie franchise, Rodney Ascher ’s genre-bending doc gives philosophers and kooks space to explain why we are living in a synthetic worldWithRoom 237, a deep dive into theories about Stanley Kubrick ’s The Shining, writer-director-animator Rodney Ascher practically invented a new sub-genre of documentary: the fathoms-five-low inspection of fandom theories and nuttery. Tonally blending sympathetic dispassion and ever-so-slight amused mockery over a fast-shuffling montage of clips that just fit under the bar of fair use, Ascher’s technique created a fascinating bra...
Source: Guardian Unlimited Science - February 4, 2021 Category: Science Authors: Leslie Felperin Tags: Film Documentary films The Matrix Artificial intelligence (AI) Technology Culture Consciousness Computing Human biology Neuroscience Psychology Philip K Dick Books Source Type: news

Janssen to Highlight Robust Solid Tumor Portfolio and Pipeline at 2021 ASCO GU
February 2, 2021 (RARITAN, N.J.) – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today it will highlight the depth of its solid tumor portfolio at the American Society of Clinical Oncology Genitourinary (ASCO GU) Cancers Symposium with 12 data presentations, including three company-sponsored oral presentations from the ERLEADA® (apalutamide) clinical development program. The virtual meeting will take place February 11-13, 2021. “We are committed to the development of innovative therapies for patients with genitourinary cancers for whom there remains a high unmet need,” said C...
Source: Johnson and Johnson - February 2, 2021 Category: Pharmaceuticals Tags: Our Company Source Type: news

Early Promise for Therapy Against Duchenne Muscular Dystrophy
THURSDAY, Jan. 28, 2021 -- An experimental gene therapy for Duchenne muscular dystrophy shows promise, a small study suggests. The severe form of muscular dystrophy -- which affects about one in 3,500 males born each year in the United States --... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - January 28, 2021 Category: General Medicine Source Type: news

What Is the Best Treatment for Muscular Dystrophy?
Title: What Is the Best Treatment for Muscular Dystrophy?Category: Diseases and ConditionsCreated: 1/28/2021 12:00:00 AMLast Editorial Review: 1/28/2021 12:00:00 AM (Source: MedicineNet Kids Health General)
Source: MedicineNet Kids Health General - January 28, 2021 Category: Pediatrics Source Type: news

Effects of autonomic nervous system functioning and tornado exposure on long-term outcomes of aggressive children - Lochman JE, Vernberg E, Glenn A, Jarrett M, McDonald K, Powell NP, Abel M, Boxmeyer CL, Kassing F, Qu L, Romero D, Bui C.
This study examined whether pre-disaster indicators of sympathetic and parasympathetic activity moderated the relation between degree of disaster exposure from an EF-4 tornado and changes in the externalizing and internalizing behavior problems of childr... (Source: SafetyLit)
Source: SafetyLit - January 18, 2021 Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news

How Do I Get Rid of My Baby ’s Moro Reflex?
Title: How Do I Get Rid of My Baby ’s Moro Reflex?Category: Diseases and ConditionsCreated: 1/15/2021 12:00:00 AMLast Editorial Review: 1/15/2021 12:00:00 AM (Source: MedicineNet Kids Health General)
Source: MedicineNet Kids Health General - January 15, 2021 Category: Pediatrics Source Type: news

TalTech's neuroscientists investigate the causes of a widespread eye disease
(Estonian Research Council) Fuchs' corneal dystrophy is one of the most common eye diseases diagnosed in almost 5% of the population of Europe aged 40 years or over. It is a hereditary eye disease that causes vision impairment and typically manifests in middle age. The first symptoms of the disease - blisters on the surface of your cornea - resemble cataract at first glance. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 13, 2021 Category: International Medicine & Public Health Source Type: news

A niche for the eye
(Stowers Institute for Medical Research) What if the degenerative eye conditions that lead to glaucoma, corneal dystrophy, and cataracts could be detected and treated before vision is impaired? Recent findings from the lab of Investigator Ting Xie, PhD, at the Stowers Institute for Medical Research point to the ciliary body as a key to unlocking this possibility. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 13, 2021 Category: International Medicine & Public Health Source Type: news

New role for Antifa: Biden's 'shock troops'
(Natural News) The election of President-elect Joe Biden does not signal the end of violent anarchist group antifa, sometimes portrayed by sympathetic media as a national anti-Trump movement. (Article by Paul Bedard republished from WashingtonExaminer.com) Instead, according to a journalist who has tracked its every move, antifa is likely to feel emboldened to challenge pro-Trump... (Source: NaturalNews.com)
Source: NaturalNews.com - January 12, 2021 Category: Consumer Health News Source Type: news

Enhanced oral uptake of exosomes opens cell therapy alternative
(Cedars-Sinai Medical Center) Cell-derived exosomes are effective in treating disease when mixed with the dominant protein in breast milk and given orally, a new Smidt Heart Institute study of laboratory mice shows. The findings, published in the peer-reviewed Journal of Extracellular Vesicles, could help develop new oral medications for treating patients with muscular dystrophy and heart failure. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 12, 2021 Category: International Medicine & Public Health Source Type: news

Science Saturday: Across time, place to find cures for inherited heart diseases
Five years ago, Jay Schneider, M.D., Ph.D., was running a lab at The University of Texas Southwestern Medical Center in Dallas. The lab focused on researching cures for the genetic muscular-wasting disorder, Duchenne muscular dystrophy. His wife, Alice Chang, M.D., had accepted an offer to work at Mayo Clinic in Rochester, Minnesota, two years before. The [...] (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - January 2, 2021 Category: Databases & Libraries Source Type: news

Predicting outcome of acquired brain injury by the evolution of paroxysmal sympathetic hyperactivity signs - Lucca LF, De Tanti A, Cava F, Romoli AM, Formisano R, Scarponi F, Estraneo A, Frattini D, Tonin P, Bertolino C, Salucci P, Hakiki B, D'Ippolito M, Zampolini M, Masotta O, Premoselli S, Interlenghi M, Salvatore C, Polidori A, Cerasa A.
In this multicenter study, we provide a systematic evaluation of the clinical variability associated with paroxysmal sympathetic hyperactivity (PSH) in patients with acquired brain injury (ABI) to determine how these signs can impact outcomes. A total of... (Source: SafetyLit)
Source: SafetyLit - December 31, 2020 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news

Wrist and hand postures when falling and description of the upper limb falling reflex - Giddins G, Giddins H.
INTRODUCTION: Falling studies, i.e. assessing what happens when an individual falls, have been conducted in controlled environments but not in field studies for ethical reasons; this potentially limits the validity and applicability of previous studies. ... (Source: SafetyLit)
Source: SafetyLit - December 30, 2020 Category: International Medicine & Public Health Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news

Giving Back: Once a Lung Transplant Recipient, Now a Surgical Nurse
WEDNESDAY, Dec. 30, 2020 -- Nurses are known for being kind, caring and sympathetic, but Brianna Fogelman brings an uncommon empathy to her nursing job at Johns Hopkins Medicine in Baltimore. Fogelman, 27, underwent a double lung transplant last... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - December 30, 2020 Category: General Medicine Source Type: news

Dilation velocity is associated with Glasgow Coma Scale scores in patients with brain injury - Thakur B, Nadim H, Atem F, Stutzman SE, Olson DWM.
The objective of this study is to determine association between DV and Glasg... (Source: SafetyLit)
Source: SafetyLit - December 23, 2020 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news

Digging deep for differences in Duchenne muscular dystrophy
(UT Southwestern Medical Center) A UT Southwestern research team has catalogued gene activity in the skeletal muscle of mice, comparing healthy animals to those carrying a genetic mutation that causes Duchene muscular dystrophy (DMD) in humans. The findings, published online recently in PNAS, could lead to new treatments for this devastating degenerative disease and insights into factors that affect muscle development. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - December 21, 2020 Category: International Medicine & Public Health Source Type: news

FDA approves Roche ’s OCREVUS® (ocrelizumab) shorter 2-hour infusion for relapsing and primary progressive multiple sclerosis
Basel, 14 December 2020 - Roche (SIX: RO, ROG; OTCQX: RHHBY) today announced that the U.S. Food and Drug Administration (FDA) has approved a shorter two-hour infusion time for OCREVUS ® (ocrelizumab), dosed twice-yearly for those living with relapsing or primary progressive multiple sclerosis (MS) who have not experienced any prior serious infusion reactions (IRs). The approval was based on data from the randomised, double-blind ENSEMBLE PLUS study.“More than 170,000 people with MS have been treated with OCREVUS - the only approved B-cell therapy with a twice-yearly dosing schedule - and it is the most prescribed...
Source: Roche Media News - December 14, 2020 Category: Pharmaceuticals Source Type: news

FDA approves Roche ’s OCREVUS® (ocrelizumab) shorter 2-hour infusion for relapsing and primary progressive multiple sclerosis
Basel, 14 December 2020 - Roche (SIX: RO, ROG; OTCQX: RHHBY) today announced that the U.S. Food and Drug Administration (FDA) has approved a shorter two-hour infusion time for OCREVUS ® (ocrelizumab), dosed twice-yearly for those living with relapsing or primary progressive multiple sclerosis (MS) who have not experienced any prior serious infusion reactions (IRs). The approval was based on data from the randomised, double-blind ENSEMBLE PLUS study.“More than 170,000 people with MS have been treated with OCREVUS - the only approved B-cell therapy with a twice-yearly dosing schedule - and it is the most prescribed...
Source: Roche Investor Update - December 14, 2020 Category: Pharmaceuticals Source Type: news

Muscle cell secrets
(Max Delbr ü ck Center for Molecular Medicine in the Helmholtz Association) A muscle fiber consists of just one cell, but many nuclei. A team at the MDC led by Professor Carmen Birchmeier has now shown just how varied these nuclei are. The study, which has been published in Nature Communications, can help us better understand muscle diseases such as Duchenne muscular dystrophy. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - December 11, 2020 Category: International Medicine & Public Health Source Type: news

PTC Announces Translarna(TM) Approval in Russia for the Treatment of Duchenne Muscular Dystrophy
SOUTH PLAINFIELD, N.J., Dec. 4, 2020 -- (Healthcare Sales & Marketing Network) -- PTC Therapeutics, Inc. (NASDAQ: PTCT) today announced that Translarna™ (ataluren) has been granted marketing approval in the Russian Federation for nonsense mutation Duchenn... Biopharmaceuticals, Regulatory PTC Therapeutics, Translarna, ataluren, Duchenne muscular dystrophy (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - December 4, 2020 Category: Pharmaceuticals Source Type: news

We won ’t release Covishield for mass use until it's proven safe and immunogenic: SII
"The incident with the Chennai volunteer though highly unfortunate was in no way induced by the vaccine and SII is sympathetic with the volunteer's medical condition. However, we would like to clarify that all the requisite regulatory and ethical processes and guidelines were followed," SII said. (Source: The Economic Times Healthcare and Biotech News)
Source: The Economic Times Healthcare and Biotech News - December 1, 2020 Category: Pharmaceuticals Source Type: news

The pupillary light reflex as a point-of-care test for suicide risk: preliminary results - McCall WV, Sareddy S, Youssef NA, Miller BJ, Rosenquist PB.
The pupillary light reflex (PLR) reflects physiologic arousal, and a potential point-of-care biomarker of suicide risk. We collected data from 9 healthy controls, 6 non-suicidal depressed patients, 7 with prior suicide attempts but not presently suicidal, ... (Source: SafetyLit)
Source: SafetyLit - November 28, 2020 Category: International Medicine & Public Health Tags: Research Methods, Surveillance and Codes, Models Source Type: news

Hurley ’ s Picks: Is Tom Brady An Enormous Baby? Let ’ s Investigate
By Michael Hurley, CBS Boston BOSTON (CBS) — Tom Brady brings out the worst in people. It’s undeniable. Whether Tom Brady does something good or bad or in between, everyone tends to lose their minds. It’s wild. That phenomenon has cooled somewhat after Brady left the lightning-rod Patriots and joined the Tampa Bay Buccaneers, a team that very few people really care about. But it came raging back to the forefront this week when a sad Tom Brady departed the field on Monday night without shaking Jared Goff’s hand. Poor Jared Goff was left standing at midfield, looking around like a lost baby giraf...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - November 25, 2020 Category: Consumer Health News Authors: CBS Boston Tags: NFL Patriots Sports Syndicated Sports Hurley's Picks Jared Goff Michael Hurley NFL Picks Sports News Tampa Bay Buccaneers Thanksgiving Tom Brady Source Type: news

Evaluation of two portable pupillometers to assess clinical utility - McKay RE, Kohn MA, Schwartz ES, Larson MD.
BACKGROUND: Pupillometers have been proposed as clinical assessment tools. We compared two pupillometers to assess measurement agreement. Materials& methods: We enrolled 30 subjects and simultaneously measured the pupil diameter and light reflex ampli... (Source: SafetyLit)
Source: SafetyLit - November 20, 2020 Category: International Medicine & Public Health Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news

Morning sympathetic activity after evening binge alcohol consumption - Greenlund IM, Cunningham HA, Tikkanen AL, Bigalke JA, Smoot CA, Durocher JJ, Carter JR.
Binge alcohol consumption elicits acute and robust increases of muscle sympathetic nerve activity (MSNA), yet the impact of evening binge drinking on morning-after MSNA is unknown. The present study examined the effects of evening binge alcohol consumption... (Source: SafetyLit)
Source: SafetyLit - November 16, 2020 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

Reflex Sympathetic Dystrophy (RSD, Complex Regional Pain Syndrome Type 1, CRPS)
Title: Reflex Sympathetic Dystrophy (RSD, Complex Regional Pain Syndrome Type 1, CRPS)Category: Diseases and ConditionsCreated: 12/31/1997 12:00:00 AMLast Editorial Review: 11/16/2020 12:00:00 AM (Source: MedicineNet Arthritis General)
Source: MedicineNet Arthritis General - November 16, 2020 Category: Rheumatology Source Type: news

The clinical utility of the cervical vestibular-evoked myogenic potential (cVEMP) in university-level athletes with concussion - Felipe L, Shelton JA.
INTRODUCTION: Concussion is defined as a mild traumatic brain injury that can occur in all sport activities. Cervical vestibular-evoked myogenic potentials (cVEMPs) are accepted to demonstrate the vestibulocollic reflex. MAIN: To evaluate subclinical cervi... (Source: SafetyLit)
Source: SafetyLit - November 13, 2020 Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news