Scientists grow 'mini-brain on the move' that can contract muscle
Cambridge researchers grew ‘organoid’ that spontaneously connected to spinal cordScientists have grown a miniature brain in a dish with a spinal cord and muscles attached, an advance that promises to accelerate the study of conditions such as motor neurone disease.The lentil-sized grey blob of human brain cells were seen to spontaneously send out tendril-like connections to link up with the spinal cord and muscle tissue, which was taken from a mouse. The muscles were then seen to visibly contract under the control of the so-called brain organoid.Continue reading... (Source: Guardian Unlimited Science)
Source: Guardian Unlimited Science - March 18, 2019 Category: Science Authors: Hannah Devlin Science correspondent Tags: Neuroscience Medical research Biology Genetics Motor neurone disease Epilepsy Society Schizophrenia Mental health University of Cambridge Stem cells Source Type: news

'It's scary': motor neurone disease spikes sevenfold in rural NSW
In centres like Griffith and Wagga Wagga, locals fear there may be something in the waterAs a child, Tania Magoci spent every weekend at Lake Wyangan near Griffith, waterskiing, swimming and boating with her family.She and her siblings would use the serpentine concrete outlet into the lake as a slippery slide. In summer, the slime from algal blooms exacerbated by the run-off from the nearby farms made it more fun to slide down the chicanes.Continue reading... (Source: Guardian Unlimited Science)
Source: Guardian Unlimited Science - March 8, 2019 Category: Science Authors: Gabrielle Chan Tags: Motor neurone disease Health New South Wales election 2019 Australia news New South Wales politics Rural Australia Medical research Water Source Type: news

Man with motor neurone disease dies after removing mask
John King spoke days before his death to raise awareness of the effects of motor neurone disease. (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - March 1, 2019 Category: Consumer Health News Source Type: news

Statins could protect against motor neurone disease
(Queen Mary University of London) High cholesterol has been found to be a possible risk factor for the development of motor neurone disease (MND), according to a large study of genetic data led in the UK by Queen Mary University of London, in collaboration with the National Institutes of Health in the USA. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 14, 2019 Category: International Medicine & Public Health Source Type: news

Robin Callard obituary
For more than 20 years Robin Callard, who has died of motor neurone disease aged 73, was professor of immunobiology at University College London, attached to the Institute of Child Health (ICH), clinical partner of Great Ormond Street hospital.Born and raised in Hamilton, New Zealand, Robin was the eldest child of Eddie Callard, an entrepreneurial Australian photographer, and Vivienne (nee Wilson), who ran a fashion shop. A fourth generation Kiwi, Vivienne was also a descendant of Joseph Priestley, the eighteenth-century radical polymath and scientist widely credited with the discovery of oxygen.Continue reading... (Source...
Source: Guardian Unlimited Science - February 13, 2019 Category: Science Authors: Michael White Tags: People in science Medical research UCL (University College London) Higher education Source Type: news

Giving a voice to my friend’s songs
When Bernie was struck by motor neurone disease, a friend helped grant his lifelong wish. (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - February 3, 2019 Category: Consumer Health News Source Type: news

Oral Cannabis Spray Relieves Spasticity in Motor Neuron Disease (CME/CE)
(MedPage Today) -- Pain scores also improved with nabiximols (Source: MedPage Today Neurology)
Source: MedPage Today Neurology - December 18, 2018 Category: Neurology Source Type: news

Cannabinoid based spray reduces spasticity, new study shows
Scientists test spray in patients with motor neurone disease Related items fromOnMedica MHRA tightens licence restrictions on valproate for women New evidence on benzodiazepine link to Alzheimer ’s Debate goes on over valproate in pregnancy Cannabis compound may help curb frequency of epileptic seizures Government to review medicinal use of cannabis (Source: OnMedica Latest News)
Source: OnMedica Latest News - December 14, 2018 Category: UK Health Source Type: news

Ezogabine treatment shown to reduce motor neuron excitability in ALS patients
(Massachusetts General Hospital) Brian Wainger, MD, PhD, of the Healey Center for ALS at Massachusetts General Hospital presented initial, top-level results of a recently completed phase 2 clinical trial of ezogabine at the Motor Neurone Disease Association annual meeting. The trial met its primary goal of measuring a reduction in motor neuron excitability in people with ALS. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - December 10, 2018 Category: International Medicine & Public Health Source Type: news

Motor neurone disease: Joe Hammond's birthday legacy for sons
Joe Hammond has motor neurone disease and is leaving a birthday legacy for his sons after he dies. (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - November 6, 2018 Category: Consumer Health News Source Type: news

Stephen Darby retires: What is motor neurone disease? Warning signs of condition revealed
STEPHEN DARBY retires: Bolton Wanderers footballer Stephen Darby has retired after being diagnosed with motor neurone disease. What is the brain and nerve condition, and what are the symptoms? Signs of condition revealed. (Source: Daily Express - Health)
Source: Daily Express - Health - September 18, 2018 Category: Consumer Health News Source Type: news

Quantification of motor neuron loss and muscular atrophy in ricin-induced focal nerve injury - Liang Y, Zhang J, Walczak P, Bulte JWM.
The objective of this study was... (Source: SafetyLit)
Source: SafetyLit - August 2, 2018 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news

Dr. Jekyll, Mr. Hyde: Study reveals healing mesenchymal cells morph and destroy muscles in models of spinal cord injury, ALS and spinal muscular atrophy
(Sanford Burnham Prebys Medical Discovery Institute) Scientists at Sanford Burnham Prebys Medical Discovery Institute (SBP), in collaboration with the Fondazione Santa Lucia IRCCS in Rome, have discovered a new disease-specific role in FAP cells in the development of muscle tissue wasting, indicating a potential new avenue for treating motor neuron diseases including spinal cord injury, ALS and spinal muscular atrophy. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - July 26, 2018 Category: Biology Source Type: news

Noel Conway: Terminally-ill man loses assisted dying challenge
Noel Conway has motor neurone disease and has been trying to change the law on assisted dying. (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - June 27, 2018 Category: Consumer Health News Source Type: news

New motor neurone neck brace developed
A new neck brace designed for people with motor neurone disease has made a "substantial difference". (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - May 30, 2018 Category: Consumer Health News Source Type: news

New motor neurone brace makes 'substantial difference'
One patient had "no doubt" that the Sheffield-designed collar had improved his quality of life. (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - May 30, 2018 Category: Consumer Health News Source Type: news

Scientific 'dream team' shed light on motor neuron death
(The Francis Crick Institute) A group of clinical neurologists, molecular biologists and computer scientists have worked together to solve the mystery of why motor neurons die in patients with motor neuron disease, published in Nature Communications this week. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 25, 2018 Category: International Medicine & Public Health Source Type: news

Leg exercise is critical to brain and nervous system health
(Frontiers) New research shows that using the legs, particularly in weight-bearing exercise, sends signals to the brain that are vital for the production of healthy neural cells. The groundbreaking study fundamentally alters brain and nervous system medicine -- giving doctors new clues as to why patients with motor neuron disease, multiple sclerosis, spinal muscular atrophy and other neurological diseases often rapidly decline when their movement becomes limited. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - May 23, 2018 Category: International Medicine & Public Health Source Type: news

Old drug provides promising new avenue for treatment of MND
(University of Liverpool) An international study led by biochemists at the University of Liverpool has shown that the drug-molecule ebselen can correct many of the toxic characteristics of a protein that causes some cases of hereditary motor neurone disease (MND). (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 17, 2018 Category: International Medicine & Public Health Source Type: news

Statins may increase people's risk of motor neurone disease
Researchers from the University of San Diego found statins, which combat high cholesterol, increase people's risk of the condition by nine-to- 100 times depending on the drug type. (Source: the Mail online | Health)
Source: the Mail online | Health - May 14, 2018 Category: Consumer Health News Source Type: news

Inquiry launched into care of 2,500 neurology patients in NI
Independent review will examine whether any early complaints relating to Dr Watt should have rung alarm bells Related items fromOnMedica Focused neurological examination in primary care A focused neurological history Wessex neurology intelligence disease insight report GPs have little confidence in primary care neurology services Motor neurone disease patients face long wait for diagnosis (Source: OnMedica Latest News)
Source: OnMedica Latest News - May 11, 2018 Category: UK Health Source Type: news

Heart drugs: Statins could increase form of motor neurone disease risk
CONTROVERSIAL heart drugs statins increase the risk of developing a form of motor neurone disease, new research shows. (Source: Daily Express - Health)
Source: Daily Express - Health - April 29, 2018 Category: Consumer Health News Source Type: news

Scientists discover protein behind motor neurone disease
An international team found that a protein causes brain cells to die when it is in the jelly phase. (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - April 20, 2018 Category: Consumer Health News Source Type: news

Scientists discover mechanism behind motor neurone disease
An international team found that a protein causes brain cells to die when it is stuck in the jelly phase. (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - April 20, 2018 Category: Consumer Health News Source Type: news

AAN: New Drug May Help Infants With Spinal Muscular Atrophy
THURSDAY, April 19, 2018 -- For infants with type 1 spinal muscular atrophy who have two copies of the survival motor neuron (SMN) 2 gene, RG7916 can increase SMN protein levels in the blood, according to a study presented at the annual meeting of... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - April 19, 2018 Category: Pharmaceuticals Source Type: news

Motor Neurone Disease: Lucy Lintott was diagnosed at 19 - 'I won't let it define me'
AS LUCY LINTOTT carried two Sunday roast dinners through the restaurant the waitress ’s life could not have been further removed from that of the eminent theoretical physicist Professor Stephen Hawking living 400 miles away in Cambridge. (Source: Daily Express - Health)
Source: Daily Express - Health - April 14, 2018 Category: Consumer Health News Source Type: news

Stephen Hawking funeral: How did he die? Symptoms of scientist's fatal condition
STEPHEN HAWKING died at the age of 76 earlier this month and his funeral is due to take place tomorrow. The physicist lived for more than 50 years with motor neurone disease, a rare condition that affects the brain and nerves. What are the symptoms? (Source: Daily Express - Health)
Source: Daily Express - Health - March 31, 2018 Category: Consumer Health News Source Type: news

Stephen Hawking may have had polio claims California physician
Renowned physicist the late Stephen Hawking may have suffered from Polio, not motor neuron disease, claims leading medical professor from the University of California. (Source: the Mail online | Health)
Source: the Mail online | Health - March 20, 2018 Category: Consumer Health News Source Type: news

The world saw Stephen Hawking as an oracle. In fact, he was wonderfully human | Philip Ball
Like no other scientist, Hawking was romanticised by the public. His death allows us to see past the fairytalePoignantly, Stephen Hawking ’sdeath at the age of 76 humanises him again. It ’s not just that, as a public icon as recognisable as any A-list actor or rock star, he came to seem a permanent fixture of the cultural landscape. It was also that his physical manifestation – the immobile body in customised wheelchair, the distinctive voice that pronounced with the oracular ca lm of HAL from 2001: A Space Odyssey – gave him the aura of a different kind of being, notoriously described by the anthro...
Source: Guardian Unlimited Science - March 15, 2018 Category: Science Authors: Philip Ball Tags: Stephen Hawking Disability Science Physics Source Type: news

The Guardian view on Stephen Hawking: the mind of God | Editorial
The death of a brilliant and complex scientist will mean we are all poorer because his mind will no longer roam the multiversesStephen Hawking was a brilliant, complex man and scientist. Diagnosed at 21 with amyotrophic lateral sclerosis, he had been expected to live a few more years. Hawkinglasted another 55. He made his name as a young Cambridge cosmologist withbreakthroughs as awesome as anything religion offers: proving that big bang theory must hold true and elucidating the link between gravity and quantum mechanics. From his wheelchair, Hawking ’s mind roamed the multiverses. It was his 1988 bestseller A Brief ...
Source: Guardian Unlimited Science - March 14, 2018 Category: Science Authors: Editorial Tags: Stephen Hawking Science NHS Society European Union World news Motor neurone disease Black holes Donald Trump Source Type: news

A young Stephen Hawking would never have made it in today ’s age of austerity | Zoe Williams
The late physicist was a genius and a visionary but it is hard to imagine those qualities thriving with cuts to disability support and the NHS under attackWhat is a fitting tribute toStephen Hawking? It ’s probably not to ask, as John Humphrys unaccountably did, whether the “science community cut him a lot of slack because he was so desperately disabled?” A more insulting idea is hard to imagine: that you spend your life overcoming adversity to get to the top of your field, then the minute you’re dead, someone speculates that you’d never have made it without the adversity.Instead, the question...
Source: Guardian Unlimited Science - March 14, 2018 Category: Science Authors: Zoe Williams Tags: Stephen Hawking Disability Society Science Vladimir Putin World news Cuts and closures Education Source Type: news

A brief history of Stephen Hawking – Science Weekly podcast
To mark the 75th birthday of the late Prof Stephen Hawking, Ian Sample talked to family, friends and colleagues about his incredible contribution to scienceSubscribe and review oniTunes,Soundcloud,Audioboom,Mixcloud andAcast, and join the discussion onFacebook andTwitterThis edition of the podcast is a repeat. It was recorded last year to mark the late Prof Hawking ’s 75th birthday.On 8 January 1942, Frank and Isobel Hawking celebrated the birth of their son,Stephen. He would become one of the most prominent scientists of all time. In a career spanning half a century, the cosmologist notched up more than 150 scientif...
Source: Guardian Unlimited Science - March 14, 2018 Category: Science Authors: Presented by Ian Sample and produced by Max Sanderson Tags: Stephen Hawking Science Physics Source Type: news

'Mind over matter': Stephen Hawking – obituary by Roger Penrose
Theoretical physicist who made revolutionary contributions to our understanding of the nature of the universeStephen Hawking dies aged 76The image ofStephen Hawking– who has died aged 76 – in his motorised wheelchair, with head contorted slightly to one side and hands crossed over to work the controls, caught the public imagination, as a true symbol of the triumph of mind over matter. As with the Delphic oracle of ancient Greece, physical impairment seemed compensated by almost supernatural gifts, which allowed his mind to roam the universe freely, upon occasion enigmatically revealing some of its secrets hidde...
Source: Guardian Unlimited Science - March 14, 2018 Category: Science Authors: Roger Penrose Tags: Stephen Hawking Physics Astronomy People in science UK news Motor neurone disease Society Source Type: news

Stephen Hawking dead: What is motor neurone disease? Symptoms of fatal condition
STEPHEN HAWKING has died at the age of 76, his family have announced. The physicist lived for more than 50 years with motor neurone disease, a rare condition that affects the brain and nerves. What are the symptoms? (Source: Daily Express - Health)
Source: Daily Express - Health - March 14, 2018 Category: Consumer Health News Source Type: news

Professor Stephen Hawking's greatest wish
The physicist, who has died aged 76, had motor neurone disease. (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - March 14, 2018 Category: Consumer Health News Source Type: news

Famed Physicist Stephen Hawking Has Died at the Age of 76
(LONDON) — Stephen Hawking, whose brilliant mind ranged across time and space though his body was paralyzed by disease, died early Wednesday, a University of Cambridge spokesman said. He was 76 years old. Hawking died peacefully at his home in Cambridge, England. The best-known theoretical physicist of his time, Hawking wrote so lucidly of the mysteries of space, time and black holes that his book, “A Brief History of Time,” became an international best seller, making him one of science’s biggest celebrities since Albert Einstein. “He was a great scientist and an extraordinary man whose work a...
Source: TIME: Science - March 14, 2018 Category: Science Authors: Robert Barr / AP Tags: Uncategorized onetime overnight remembrance Source Type: news

Changing size of neurons could shed light on new treatments for motor neurone disease
(The Physiological Society) New research published in The Journal of Physiology improves our understanding of how motor nerve cells (neurons) respond to motor neurone disease, which could help us identify new treatment options. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 4, 2018 Category: International Medicine & Public Health Source Type: news

ALS-linked protein's journey into nervous system cells more complex than we thought
(University of Bath) University of Bath scientists have developed a better understanding of a key protein associated with brain diseases including ALS (motor neurone disease) and dementia by studying how it enters central nervous system cells. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 28, 2018 Category: International Medicine & Public Health Source Type: news

Motor neuron disease tears through Welsh family
A family from Clydach, Wales, have lost five members of their family to motor neurone disease. However, Mandy Duguid is determined to aid in funding for research into the disease (Source: the Mail online | Health)
Source: the Mail online | Health - February 13, 2018 Category: Consumer Health News Source Type: news

Research uncovers gene network that regulates motor neuron formation during embryonic development
(University of California - Los Angeles Health Sciences) UCLA researchers have discovered the inner workings of a gene network that regulates the development of spinal motor neurons in the growing chicken and mouse embryo. The research also answers a long-standing question about why motor neurons, the nerve cells of the spinal cord that control muscle movement, form much faster than other types of neurons. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 1, 2018 Category: International Medicine & Public Health Source Type: news

Nurse wins funding to improve motor neurone disease care
A specialist nurse has been named as one of the first two recipients of a scholarship fund set up in memory of motor neurone disease (MND) campaigner Gordon Aikman. (Source: Nursing Times)
Source: Nursing Times - January 22, 2018 Category: Nursing Source Type: news

This may be a turning point in treating neurodegenerative diseases
Success in trials for Huntington ’s and Spinal Muscular Atrophy raises hopes that diseases such as Alzheimer’s and ALS could be tackled using a new class of drugsThey are diseases that threaten more than physical health: memories, personality, and the ability to move and speak are incrementally stolen. And until this year neurodegenerative diseases, from Alzheimer ’s toALS, had been entirely unstoppable.However, abreakthrough in Huntington ’s disease this week suggests this bleak picture could be about to change. The landmark trial was the first to show that the genetic defect that causes Huntington...
Source: Guardian Unlimited Science - December 15, 2017 Category: Science Authors: Hannah Devlin Science correspondent Tags: Medical research Neuroscience Alzheimer's Motor neurone disease Parkinson's disease Genetics Drugs Health Biology Source Type: news

Dying mother's bid to raise funds to keep her children out of care
Sam Kyme has motor neurone disease and wants her two sons to live with her sister in Australia. (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - November 16, 2017 Category: Consumer Health News Source Type: news

What is ALS? New drug is 'GAME changer' for Ice Bucket Challenge disease sufferers 
A NEW ALS drug has been hailed as “a game changer” in reducing symptoms of the motor neurone disease. (Source: Daily Express - Health)
Source: Daily Express - Health - October 20, 2017 Category: Consumer Health News Source Type: news

The eyes have it: how technology allows you to speak when all you can do is blink
Developments in eye-gaze technology – which converts minute movements of the eye into spoken words – are opening up undreamed of opportunities for people with motor neurone syndromeSteve Thomas and I are talking about brain implants. Bonnie Tyler ’s Holding Out For a Hero is playing in the background and for a moment I almost forget that a disease has robbed Steve of his speech. The conversation breaks briefly; now I see his wheelchair, his ventilator, his hospital bed.Steve, a software engineer, was diagnosed with ALS (amyotrophic lateral sclerosis, a type ofmotor neurone disease) aged 50. He knew i...
Source: Guardian Unlimited Science - October 16, 2017 Category: Science Authors: Jules Montague Tags: Motor neurone disease Medical research Technology Society Science Health & wellbeing Life and style Source Type: news

An uncomfortable truth - not every life is worth living  
This week, Noel Conway, who has motor neurone disease, lost his High Court battle to allow assisted dying, writes DR MAX PEMBERTON. (Source: the Mail online | Health)
Source: the Mail online | Health - October 7, 2017 Category: Consumer Health News Source Type: news

Noel Conway: Terminally ill man loses right-to-die case
The High Court ruled the law should not be changed after hearing the case of man with motor neurone disease. (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - October 5, 2017 Category: Consumer Health News Source Type: news

The NHS saved me. As a scientist, I must help to save it | Stephen Hawking
The crisis in the health service has been created by politicians who want to privatise it – when public opinion, and the evidence, point in the opposite directionLike many people, I have personal experience of the NHS. In my case, medical care, personal life and scientific life are all intertwined. I have received a large amount of high-quality NHS treatment andwould not be here today if it were not for the service.The care I have received since being diagnosed with motor neurone disease as a student in 1962 has enabled me to live my life as I want, and to contribute to major advances in our understanding of the univ...
Source: Guardian Unlimited Science - August 18, 2017 Category: Science Authors: Stephen Hawking Tags: NHS Privatisation Business Economic policy Health Society Politics Health policy Public services policy UK news Source Type: news

Motor neurone disease symptoms: Weakness in joints could be sign of MND
MOTOR neurone disease is a progressive disease that attacks the motor neurones, or nerves, in the brain and spinal cord. (Source: Daily Express - Health)
Source: Daily Express - Health - August 15, 2017 Category: Consumer Health News Source Type: news