Initial protective role of nervous system's 'star-shaped cells' in sporadic motor neuron disease uncovered
(The Francis Crick Institute) Support cells in the nervous system help protect motor neurons in the early-stages of sporadic motor neuron disease, according to new research from the Crick and UCL. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 10, 2020 Category: International Medicine & Public Health Source Type: news

Roche ’s Risdiplam meets primary endpoint in pivotal FIREFISH trial in infants with type 1 spinal muscular atrophy
             Basel, 23 January 2020 - Roche (SIX: RO, ROG; OTCQX: RHHBY) today announced positive topline results from the pivotal Part 2 of the FIREFISH study, evaluating risdiplam in infants aged 1-7 months with Type 1 spinal muscular atrophy (SMA). The primary outcome measure of the study was the proportion of infants sitting without support for at least five seconds at 12-months of treatment, assessed by the Gross Motor Scale of the Bayley Scales of Infant and Toddler Development Third Edition (BSID-III). Safety for risdiplam in the FIREFISH study was con...
Source: Roche Investor Update - January 23, 2020 Category: Pharmaceuticals Source Type: news

Roche ’s Risdiplam meets primary endpoint in pivotal FIREFISH trial in infants with type 1 spinal muscular atrophy
             Basel, 23 January 2020 - Roche (SIX: RO, ROG; OTCQX: RHHBY) today announced positive topline results from the pivotal Part 2 of the FIREFISH study, evaluating risdiplam in infants aged 1-7 months with Type 1 spinal muscular atrophy (SMA). The primary outcome measure of the study was the proportion of infants sitting without support for at least five seconds at 12-months of treatment, assessed by the Gross Motor Scale of the Bayley Scales of Infant and Toddler Development Third Edition (BSID-III). Safety for risdiplam in the FIREFISH study was con...
Source: Roche Media News - January 23, 2020 Category: Pharmaceuticals Source Type: news

MND: The search for new treatments
A major study will assess if new - and existing - drugs can help people with motor neurone disease. (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - January 15, 2020 Category: Consumer Health News Source Type: news

Urgent research needed into contact sports link motor neurone disease after Rob Burrow
Leading doctors and scientists told MailOnline they were 'frustrated' the cause of the cruel condition had not yet been pinpointed. English rugby stalwart Rob Burrow was diagnosed this week. (Source: the Mail online | Health)
Source: the Mail online | Health - December 20, 2019 Category: Consumer Health News Source Type: news

Motor neurone disease 'linked to cholesterol'
UK scientists say their discovery could help in the search for new treatments. (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - December 18, 2019 Category: Consumer Health News Source Type: news

FDA grants priority review to Roche ’s risdiplam for spinal muscular atrophy
Roche (SIX: RO, ROG; OTCQX: RHHBY) announced that the U.S. Food and Drug Administration (FDA) has accepted the New Drug Application (NDA) and granted Priority Review for risdiplam, an investigational survival motor neuron-2 (SMN-2) splicing modifier for SMA. Risdiplam is designed to increase and sustain SMN protein levels both throughout the central nervous system and peripheral tissues of the body. (Source: World Pharma News)
Source: World Pharma News - November 27, 2019 Category: Pharmaceuticals Tags: Featured Roche Business and Industry Source Type: news

FDA grants priority review to Roche ’s risdiplam for spinal muscular atrophy
Roche today announced that the U.S. Food and Drug Administration (FDA) has accepted the New Drug Application (NDA) and granted Priority Review for risdiplam, an investigational survival motor neuron-2 (SMN-2) splicing modifier for SMA. (Source: Roche Media News)
Source: Roche Media News - November 25, 2019 Category: Pharmaceuticals Source Type: news

FDA grants priority review to Roche ’s risdiplam for spinal muscular atrophy
Roche today announced that the U.S. Food and Drug Administration (FDA) has accepted the New Drug Application (NDA) and granted Priority Review for risdiplam, an investigational survival motor neuron-2 (SMN-2) splicing modifier for SMA. (Source: Roche Investor Update)
Source: Roche Investor Update - November 25, 2019 Category: Pharmaceuticals Source Type: news

AI project to preserve people's voices in effort to tackle speech loss
Clinic hopes to help those at risk of losing ability to speak maintain sense of identityA pioneering centre aimed at preserving and re-creating people ’s voices using artificial intelligence has opened in the US, with researchers hoping it will change the lives of people who face losing their ability to speak.Researchers say the venture – a joint effort between Northeastern University in Boston and the company VocaliD – could play an important role in maintaining a sense of identity among those with conditions ranging from throat cancer to motor neurone disease, by offering them the chance to sound like t...
Source: Guardian Unlimited Science - November 9, 2019 Category: Science Authors: Nicola Davis Tags: Artificial intelligence (AI) Computing Consciousness Human biology Neuroscience Psychology Technology World news Source Type: news

Ex-Liverpool player Stephen Darby on fight with 'brutal disease'
Stephen Darby, who is married to England women's captain Steph Houghton, has motor neurone disease. (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - October 27, 2019 Category: Consumer Health News Source Type: news

RightCare Progressive Neurological Conditions Toolkit
This toolkit will support systems to understand the priorities in care for people living with various progressive neurological conditions including multiple sclerosis (MS), motor neurone disease (MND), Parkinson's and the atypical Parkinsonism's of multiple system atrophy (MSA), progressive supranuclear palsy (PSP) and coticobasal degeneration (CBD). It provides the opportunity to assess and benchmark current systems to find opportunities for improvement. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - October 17, 2019 Category: Consumer Health News Source Type: news

Is This a Fasciculation?
Discussion Benign fasciculations are very common and occur in up to 70% of the general population. They occur at different points in people’s lives. They can be brought out by stress, poor sleep hygiene and caffeine. Caffeine has numerous uses especially for regulating sleep and attention. However too much can cause restlessness, jitteriness and sleep deprivation too. The recommended amount of caffeine for a teenager is
Source: PediatricEducation.org - September 16, 2019 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

MRC backs MSD and Francis Crick Institute collaboration to tackle motor neurone disease
Scientists at global biopharmaceutical company MSD and the Francis Crick Institute have started a unique new collaboration to understand the causes of motor neurone disease and identify potential targets for future treatments, co-funded by the Medical Research Council and MSD. (Source: Medical Research Council General News)
Source: Medical Research Council General News - August 29, 2019 Category: Research Source Type: news

MSD backs MSD and Francis Crick Institute collaboration to tackle motor neurone disease
Scientists at global biopharmaceutical company MSD and the Francis Crick Institute have started a unique new collaboration to understand the causes of motor neurone disease and identify potential targets for future treatments, co-funded by the Medical Research Council and MSD. (Source: Medical Research Council General News)
Source: Medical Research Council General News - August 27, 2019 Category: Research Source Type: news

Search for motor neurone disease cure gathers pace
Crick Institute links up with drug company Merck to tackle degenerative brain disorder (Source: FT.com - Drugs and Healthcare)
Source: FT.com - Drugs and Healthcare - August 20, 2019 Category: Pharmaceuticals Source Type: news

CCGs offered help tackling neurological conditions
Better care for Parkinson ’s, MS and motor neurone disease Related items fromOnMedica 'Revived' dead pig brains offer new research hopes NICE issues guidelines on neurological conditions GPs have duty to protect abused vulnerable adults NICE sets care standards for spasticity GPs must greatly improve deaf awareness (Source: OnMedica Latest News)
Source: OnMedica Latest News - August 16, 2019 Category: UK Health Source Type: news

The son giving the gift of his voice to his father
Bob Alderman, 70, lost his voice to motor neurone disease - until his son stepped in to help. (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - August 13, 2019 Category: Consumer Health News Source Type: news

Do we have a right to know if we could have the Huntington ’s disease gene?
Not telling your child that this hereditary condition is in the family can be devastating later onOn a lazy Sunday morning in May last year, Isobel Lloyd was at her boyfriend ’s house, having coffee with his mum. The conversation had worked around to Lloyd’s grandma – her mother’s mother – who’d died in her 50s, when Lloyd was very young. Lloyd’s only memories of her had been hospice visits where her grandma lay bedbound, unable to talk or swallow, with no control over how her body moved. Lloyd had forgotten the name of her grandma’s disease, hadn’t thought about it in ...
Source: Guardian Unlimited Science - August 10, 2019 Category: Science Authors: Anna Moore Tags: Huntington's disease Family Health Life and style Psychology Science & wellbeing Society Source Type: news

Charlotte Hawkins: We won't stand back as our dying loved ones are treated ‘shamefully’
MOTOR NEURONE disease gradually stops messages from the motor neurones reaching the muscles. Up to 5,000 adults in the UK will have it at any one time. For about half of patients life expectancy is three years from first symptoms. (Source: Daily Express - Health)
Source: Daily Express - Health - August 4, 2019 Category: Consumer Health News Source Type: news

Super-fit Simon was struck by a fatal brain disease at just 52
Simon Brennan, from North London, was diagnosed with motor neurone disease, last year. This is his incredible story. (Source: the Mail online | Health)
Source: the Mail online | Health - July 29, 2019 Category: Consumer Health News Source Type: news

Decoding the causes of motor neuron disease: A new study shows the impact of genetics
(Trinity College Dublin) Researchers from Trinity College Dublin have conducted the largest ever study involving 1117 people diagnosed with motor neurone disease to address the question of " nature versus nurture " in the causes of MND. The team from the Trinity MND Research Group found that one in 347 men and one in 436 women can be expected to develop motor neurone disease (MND) during their lifetime. Their research has been published in the American medical journal JAMA Neurology. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - July 24, 2019 Category: International Medicine & Public Health Source Type: news

Motor neurone disease researchers find link to microbes in gut
Study could eventually lead to new treatments for neurodegenerative conditionScientists have found tantalising clues that the devastating condition motor neurone disease may be linked to changes in microbes that live in the gut.Studies in mice revealed that animals bred to develop amyotrophic lateral sclerosis (ALS), a form of the disease that affectedthe cosmologist Stephen Hawking, improved and lived longer when they were given an organism calledAkkermansia muciniphila.Continue reading... (Source: Guardian Unlimited Science)
Source: Guardian Unlimited Science - July 22, 2019 Category: Science Authors: Ian Sample Science editor Tags: Motor neurone disease Medical research Science Society Microbiology Source Type: news

Gut bacteria may have motor neurone disease role
Finding could lead to the first treatment for the devastating disease. (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - July 22, 2019 Category: Consumer Health News Source Type: news

Needs and preferences for psychological interventions of people with motor neuron disease - Weeks KR, Gould RL, Mcdermott C, Lynch J, Goldstein LH, Graham CD, McCracken L, Serfaty M, Howard R, Al-Chalabi A, White D, Bradburn M, Young T, Cooper C, Shaw DPJ, Lawrence V.
Background: There is a lack of knowledge about what factors may impede or facilitate engagement in psychological interventions in people with motor neuron disease (pwMND) and how such interventions can be adapted to best meet the needs of this popul... (Source: SafetyLit)
Source: SafetyLit - July 15, 2019 Category: International Medicine & Public Health Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news

Protein offers protection against nerve degeneration in ALS model
(Boston University School of Medicine) Increasing the levels of the anti-aging protein hormone Klotho improves the neurological deficits and prolongs life span in an experimental model with Amyotrophic Lateral Sclerosis (ALS). In addition, brain immune cells called microglia play an important role in protecting the brain against inflammation and, likely, motor neuron loss in this model. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 27, 2019 Category: International Medicine & Public Health Source Type: news

Family brand terminal illness assessments 'degrading'
Susan Hill had been diagnosed with motor neurone disease when she had "bizarre" benefit claim tests. (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - June 22, 2019 Category: Consumer Health News Source Type: news

Cannabis-based drug can ease muscle tightness in patients with motor neuron disease, study finds
(Natural News) A newly developed oral spray could further improve the effects of anti-spasticity treatments on the symptoms of muscle stiffness. Called “naximols,” the medicine employed delta-9 tetrahydrocannabinol THC and cannabidiol, two natural compounds derived from cannabis (Cannabis sativa). Muscle spasticity often causes disability and lower quality of life in patients with motor neuron disease. The... (Source: NaturalNews.com)
Source: NaturalNews.com - June 2, 2019 Category: Consumer Health News Source Type: news

How mutations lead to neurodegenerative disease
(University of Adelaide) Scientists have discovered how mutations in DNA can cause neurodegenerative disease. The discovery is an important step towards better treatment to slow the progression or delay onset in a range of incurable diseases such as Huntington's and motor neurone disease - possibly through the use, in new ways, of existing anti-inflammatory drugs. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 13, 2019 Category: International Medicine & Public Health Source Type: news

'Cruel motor neurone disease robbed my Dad of summer that never was'
HAVE you ever read a novel and hoped you would die before you reached the final page? My dad did. (Source: Daily Express - Health)
Source: Daily Express - Health - April 28, 2019 Category: Consumer Health News Source Type: news

Spatiotemporal dynamics of molecular pathology in amyotrophic lateral sclerosis
Paralysis occurring in amyotrophic lateral sclerosis (ALS) results from denervation of skeletal muscle as a consequence of motor neuron degeneration. Interactions between motor neurons and glia contribute to motor neuron loss, but the spatiotemporal ordering of molecular events that drive these processes in intact spinal tissue remains poorly understood. Here, we use spatial transcriptomics to obtain gene expression measurements of mouse spinal cords over the course of disease, as well as of postmortem tissue from ALS patients, to characterize the underlying molecular mechanisms in ALS. We identify pathway dynamics, distin...
Source: ScienceNOW - April 4, 2019 Category: Science Authors: Maniatis, S., Äijö, T., Vickovic, S., Braine, C., Kang, K., Mollbrink, A., Fagegaltier, D., Andrusivova, Z., Saarenpää, S., Saiz-Castro, G., Cuevas, M., Watters, A., Lundeberg, J., Bonneau, R., Phatnani, H. Tags: Molecular Biology, Neuroscience reports Source Type: news

Lauren Sciences LLC wins AU$1 million grant award from FightMND
(Lauren Sciences LLC) Lauren Sciences LLC, the private New York biotechnology company developing transformative V-Smart ® Nanomedicines for brain diseases, today announced it was awarded an AU$1 million translational grant from FightMND. The FightMND grant will advance Lauren Sciences development of LAUR-301, its novel V-Smart ® Nanomedicine for ALS (amyotrophic lateral sclerosis), also known as Lou Gehrig's disease, or motor neuron disease (MND). (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 2, 2019 Category: International Medicine & Public Health Source Type: news

Scientists grow 'mini-brain on the move' that can contract muscle
Cambridge researchers grew ‘organoid’ that spontaneously connected to spinal cordScientists have grown a miniature brain in a dish with a spinal cord and muscles attached, an advance that promises to accelerate the study of conditions such as motor neurone disease.The lentil-sized grey blob of human brain cells were seen to spontaneously send out tendril-like connections to link up with the spinal cord and muscle tissue, which was taken from a mouse. The muscles were then seen to visibly contract under the control of the so-called brain organoid.Continue reading... (Source: Guardian Unlimited Science)
Source: Guardian Unlimited Science - March 18, 2019 Category: Science Authors: Hannah Devlin Science correspondent Tags: Neuroscience Medical research Biology Genetics Motor neurone disease Epilepsy Society Schizophrenia Mental health University of Cambridge Stem cells Source Type: news

'It's scary': motor neurone disease spikes sevenfold in rural NSW
In centres like Griffith and Wagga Wagga, locals fear there may be something in the waterAs a child, Tania Magoci spent every weekend at Lake Wyangan near Griffith, waterskiing, swimming and boating with her family.She and her siblings would use the serpentine concrete outlet into the lake as a slippery slide. In summer, the slime from algal blooms exacerbated by the run-off from the nearby farms made it more fun to slide down the chicanes.Continue reading... (Source: Guardian Unlimited Science)
Source: Guardian Unlimited Science - March 8, 2019 Category: Science Authors: Gabrielle Chan Tags: Motor neurone disease Health New South Wales election 2019 Australia news New South Wales politics Rural Australia Medical research Water Source Type: news

Man with motor neurone disease dies after removing mask
John King spoke days before his death to raise awareness of the effects of motor neurone disease. (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - March 1, 2019 Category: Consumer Health News Source Type: news

Statins could protect against motor neurone disease
(Queen Mary University of London) High cholesterol has been found to be a possible risk factor for the development of motor neurone disease (MND), according to a large study of genetic data led in the UK by Queen Mary University of London, in collaboration with the National Institutes of Health in the USA. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 14, 2019 Category: International Medicine & Public Health Source Type: news

Robin Callard obituary
For more than 20 years Robin Callard, who has died of motor neurone disease aged 73, was professor of immunobiology at University College London, attached to the Institute of Child Health (ICH), clinical partner of Great Ormond Street hospital.Born and raised in Hamilton, New Zealand, Robin was the eldest child of Eddie Callard, an entrepreneurial Australian photographer, and Vivienne (nee Wilson), who ran a fashion shop. A fourth generation Kiwi, Vivienne was also a descendant of Joseph Priestley, the eighteenth-century radical polymath and scientist widely credited with the discovery of oxygen.Continue reading... (Source...
Source: Guardian Unlimited Science - February 13, 2019 Category: Science Authors: Michael White Tags: People in science Medical research UCL (University College London) Higher education Source Type: news

Giving a voice to my friend’s songs
When Bernie was struck by motor neurone disease, a friend helped grant his lifelong wish. (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - February 3, 2019 Category: Consumer Health News Source Type: news

Oral Cannabis Spray Relieves Spasticity in Motor Neuron Disease (CME/CE)
(MedPage Today) -- Pain scores also improved with nabiximols (Source: MedPage Today Neurology)
Source: MedPage Today Neurology - December 18, 2018 Category: Neurology Source Type: news

Cannabinoid based spray reduces spasticity, new study shows
Scientists test spray in patients with motor neurone disease Related items fromOnMedica MHRA tightens licence restrictions on valproate for women New evidence on benzodiazepine link to Alzheimer ’s Debate goes on over valproate in pregnancy Cannabis compound may help curb frequency of epileptic seizures Government to review medicinal use of cannabis (Source: OnMedica Latest News)
Source: OnMedica Latest News - December 14, 2018 Category: UK Health Source Type: news

Ezogabine treatment shown to reduce motor neuron excitability in ALS patients
(Massachusetts General Hospital) Brian Wainger, MD, PhD, of the Healey Center for ALS at Massachusetts General Hospital presented initial, top-level results of a recently completed phase 2 clinical trial of ezogabine at the Motor Neurone Disease Association annual meeting. The trial met its primary goal of measuring a reduction in motor neuron excitability in people with ALS. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - December 10, 2018 Category: International Medicine & Public Health Source Type: news

Motor neurone disease: Joe Hammond's birthday legacy for sons
Joe Hammond has motor neurone disease and is leaving a birthday legacy for his sons after he dies. (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - November 6, 2018 Category: Consumer Health News Source Type: news

Shocking New Video Shows Motor Neurone Disease Devastatingly Fast Effects
New video from MND Association - The Ride - shows devastating effects of Motor Neurone Disease. The film features 38 year old Luke as his ability to walk, move and speak are taken away from him within just 2 years (Source: Disabled World)
Source: Disabled World - September 28, 2018 Category: Disability Tags: Awareness Source Type: news

Stephen Darby retires: What is motor neurone disease? Warning signs of condition revealed
STEPHEN DARBY retires: Bolton Wanderers footballer Stephen Darby has retired after being diagnosed with motor neurone disease. What is the brain and nerve condition, and what are the symptoms? Signs of condition revealed. (Source: Daily Express - Health)
Source: Daily Express - Health - September 18, 2018 Category: Consumer Health News Source Type: news

Quantification of motor neuron loss and muscular atrophy in ricin-induced focal nerve injury - Liang Y, Zhang J, Walczak P, Bulte JWM.
The objective of this study was... (Source: SafetyLit)
Source: SafetyLit - August 2, 2018 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news

Dr. Jekyll, Mr. Hyde: Study reveals healing mesenchymal cells morph and destroy muscles in models of spinal cord injury, ALS and spinal muscular atrophy
(Sanford Burnham Prebys Medical Discovery Institute) Scientists at Sanford Burnham Prebys Medical Discovery Institute (SBP), in collaboration with the Fondazione Santa Lucia IRCCS in Rome, have discovered a new disease-specific role in FAP cells in the development of muscle tissue wasting, indicating a potential new avenue for treating motor neuron diseases including spinal cord injury, ALS and spinal muscular atrophy. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - July 26, 2018 Category: Biology Source Type: news

Noel Conway: Terminally-ill man loses assisted dying challenge
Noel Conway has motor neurone disease and has been trying to change the law on assisted dying. (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - June 27, 2018 Category: Consumer Health News Source Type: news

New motor neurone neck brace developed
A new neck brace designed for people with motor neurone disease has made a "substantial difference". (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - May 30, 2018 Category: Consumer Health News Source Type: news

New motor neurone brace makes 'substantial difference'
One patient had "no doubt" that the Sheffield-designed collar had improved his quality of life. (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - May 30, 2018 Category: Consumer Health News Source Type: news