Epithelioid Sarcoma Presenting As a Fever of Unknown Origin Epithelioid Sarcoma Presenting As a Fever of Unknown Origin
This case highlights the need for paying attention to even seemingly insignificant symptoms when attempting to determine the cause of fever of unknown origin.Journal of Medical Case Reports (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - February 27, 2019 Category: Consumer Health News Tags: Family Medicine/Primary Care Journal Article Source Type: news

Gastric Acid Suppression & Oral Cancer Therapy Should Not Mix Gastric Acid Suppression & Oral Cancer Therapy Should Not Mix
Gastric acid suppressants may reduce absorption of oral cancer drugs, as shown in a study with pazopanib for sarcoma in which the interaction led to worse outcomes. Can this be practice changing?Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - February 19, 2019 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

Ultragenyx CMO helms rare disease team
Dr. Camille Bedrosian has spent much of her career in the biotech sector, primarily working with rare diseases. “It’s a different level of commitment and tenacity, not taking no for an answer to solve a problem,” she said. “It’s been a little over two decades for me, and I’ve always been in rare disease.” Bedrosian previously helped to build a development group at Alexion Pharmaceuticals Inc. working on small molecules for oncology, focusing on rare cancers such as sarcoma. Camille… (Source: bizjournals.com Health Care:Pharmaceuticals headlines)
Source: bizjournals.com Health Care:Pharmaceuticals headlines - February 14, 2019 Category: Pharmaceuticals Authors: Nathan Falstreau Source Type: news

Cancer-stricken woman, 27, desperately tries to raise £500,000 for experimental treatment in the US
Hope Stringer, from Essex, is facing soft tissue sarcoma for the third time in five years. She was told the cancer had returned and spread weeks after she became engaged. (Source: the Mail online | Health)
Source: the Mail online | Health - February 11, 2019 Category: Consumer Health News Source Type: news

Olaratumab for Sarcoma Under Review After Negative Trial Olaratumab for Sarcoma Under Review After Negative Trial
The product has been used in combination with doxorubicin in patients with soft tissue sarcoma, but negative results from a confirmatory trial put its future in question.International Approvals (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - February 1, 2019 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

WATCH: What is Ewing sarcoma?
Ewing sarcoma is a rare type of cancer occurring in the bones or in the soft tissue around the bones. (Source: ABC News: Health)
Source: ABC News: Health - January 27, 2019 Category: Consumer Health News Tags: Health Source Type: news

After winning accelerated approval, Lilly ’s cancer drug fails in study
An Eli Lilly treatment for advanced soft-tissue sarcoma missed the mark in a phase 3 study and will no longer be prescribed. (Source: PharmaManufacturing.com)
Source: PharmaManufacturing.com - January 21, 2019 Category: Pharmaceuticals Source Type: news

Lartruvo Fails in Confirmatory Sarcoma Trial
(MedPage Today) -- Lilly suspending promotion; could drug be pulled from U.S. market? (Source: MedPage Today Public Health)
Source: MedPage Today Public Health - January 18, 2019 Category: American Health Source Type: news

Lilly Reports Results of Phase 3 Soft Tissue Sarcoma Study of LARTRUVO(R)
Study did not meet the primary endpoints of overall survival (OS) in the full study population or in the leiomyosarcoma (LMS) sub-population; there was no difference in survival between the study arms for either population. There were no new safety sign... Biopharmaceuticals, Oncology Eli Lilly, LARTRUVO, olaratumab, soft tissue sarcoma, leiomyosarcoma (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - January 18, 2019 Category: Pharmaceuticals Source Type: news

High-Dose Chemo and Stem-Cell Rescue for Ewing Sarcoma High-Dose Chemo and Stem-Cell Rescue for Ewing Sarcoma
Consolidation high-dose chemotherapy with busulfan and melphalan may better survival in patients with Ewing sarcoma at high risk for relapse.Journal of Clinical Oncology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - January 11, 2019 Category: Consumer Health News Tags: Hematology-Oncology Journal Article Source Type: news

Opportunities in precision oncology and genomic profiling services in Asia Pacific
Launched in 2010 with a $25 million Series A financing led by Third Rock Ventures, Foundation Medicine released its first commercial assay called FoundationOne in 2012. The company develops, manufactures, and sells genomic profiling assays based on next-generation sequencing technology for solid tumours, hematologic malignancies, and sarcomas. In December 2017, the company ’s assay FoundationOne CDx received approval from the US Food and Drug Administration (FDA). (Source: mobihealthnews)
Source: mobihealthnews - January 11, 2019 Category: Information Technology Source Type: news

New insights into a rare type of cancer open novel avenues of study
(Karolinska Institutet) Undifferentiated uterine sarcoma is a very rare but extremely aggressive cancer type. It can be divided into four groups with different characteristics of clinical importance -- a new study at Karolinska Institutet in Sweden reveals. The results, published in the journal Clinical Cancer Research, also show that the survival rate of patients with a certain type of tumour is better than predicted. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - January 8, 2019 Category: Cancer & Oncology Source Type: news

Rufus Wainwright: 2018 WebMD Health Hero, Ambassador
After losing their mother to clear cell sarcoma, the singer-songwriter and his sister wanted to honor her. Learn more about the foundation, which sponsors research into this rare type of cancer, and the woman who inspired it. (Source: WebMD Health)
Source: WebMD Health - January 2, 2019 Category: Consumer Health News Source Type: news

Woman's face was rebuilt using her shoulder bone and back muscle
Jen Taylor, 30, from London, needed seven months of chemotherapy before a life-changing operation to treat sarcoma with which she was diagnosed in August 2017 after noticing a lump. (Source: the Mail online | Health)
Source: the Mail online | Health - December 29, 2018 Category: Consumer Health News Source Type: news

Skin Cancer | Medscape Skin Cancer | Medscape
Nonmelanoma skin cancer primarily comprises basal cell carcinoma and squamous cell carcinoma. Other, rarer types of nonmelanoma skin cancer include dermatofibrosarcoma protuberans, Merkel cell carcinoma, and Kaposi's sarcoma. (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - December 28, 2018 Category: Consumer Health News Tags: Resource Center Source Type: news

Desmoid Tumors: Treatment Breakthrough With Sorafenib Desmoid Tumors: Treatment Breakthrough With Sorafenib
Desmoid tumors, a rare form of sarcoma, may finally have a standard of care after a National Cancer Institute trial showed that sorafenib was able to reduce progression rates by more than 85%.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - December 19, 2018 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

5 Things to Know About Sarcoma 5 Things to Know About Sarcoma
Although advances in treating sarcoma have historically been slow, new emerging therapies in the field of oncology are changing the way oncologists look at sarcoma.Medscape Oncology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - December 19, 2018 Category: Consumer Health News Tags: Hematology-Oncology Article Source Type: news

Uncovering a key mechanism in assembly of Avian Sarcoma Virus, a relative of HIV-1
(University of Alabama at Birmingham) Researchers used NMR to detail how the matrix domain of the Avian Sarcoma Virus Gag protein binds to certain phospholipids. These phospholipids are vital for Gag protein binding to the plasma membrane of a cell, as the virus replicates and takes its first step toward virus formation and budding. ASV is widely used as a model to study mechanisms of HIV infection and replication. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - December 18, 2018 Category: Infectious Diseases Source Type: news

New drug seeks receptors in sarcoma cells, attacks tumors in animal trials
(University of Illinois at Urbana-Champaign) A new compound that targets a receptor within sarcoma cancer cells shrank tumors and hampered their ability to spread in mice and pigs, a study from researchers at the University of Illinois reports.The researchers conducted a multi-year, cross-disciplinary study that went from screening potential drug candidates to identifying and synthesizing one compound, to packaging it into nanoparticles for delivery in cells, to testing it in cell cultures and finally in mice and pigs with sarcoma tumors. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - December 13, 2018 Category: Cancer & Oncology Source Type: news

Utility of Genomic Profiling in Treating Advanced Sarcomas Utility of Genomic Profiling in Treating Advanced Sarcomas
Molecular profiling may be particularly useful in guiding therapy of sarcoma with an unclear diagnosis or rare subtype.JCO Precision Oncology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - December 10, 2018 Category: Consumer Health News Tags: Hematology-Oncology Journal Article Source Type: news

LZTR1 is a regulator of RAS ubiquitination and signaling
In genetic screens aimed at understanding drug resistance mechanisms in chronic myeloid leukemia cells, inactivation of the cullin 3 adapter protein-encoding leucine zipper-like transcription regulator 1 (LZTR1) gene led to enhanced mitogen-activated protein kinase (MAPK) pathway activity and reduced sensitivity to tyrosine kinase inhibitors. Knockdown of the Drosophila LZTR1 ortholog CG3711 resulted in a Ras-dependent gain-of-function phenotype. Endogenous human LZTR1 associates with the main RAS isoforms. Inactivation of LZTR1 led to decreased ubiquitination and enhanced plasma membrane localization of endogenous KRAS (V...
Source: ScienceNOW - December 6, 2018 Category: Science Authors: Bigenzahn, J. W., Collu, G. M., Kartnig, F., Pieraks, M., Vladimer, G. I., Heinz, L. X., Sedlyarov, V., Schischlik, F., Fauster, A., Rebsamen, M., Parapatics, K., Blomen, V. A., Müller, A. C., Winter, G. E., Kralovics, R., Brummelkamp, T. R., Mlod Tags: Cell Biology, Medicine, Diseases reports Source Type: news

Medical News Today: Does HIV increase cancer risk?
HIV can weaken a person ’s immune system, which can increase the risk of certain types of cancer. Such cancers include Kaposi’s sarcoma, non-Hodgkin lymphoma, and cervical, lung, anal, and oral cancer. However, effective treatment can significantly reduce the risk of developing these cancers. Learn more here. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - December 4, 2018 Category: Consumer Health News Tags: HIV and AIDS Source Type: news

Next Frontiers in Systemic Therapy for Soft Tissue Sarcoma Next Frontiers in Systemic Therapy for Soft Tissue Sarcoma
Molecularly targeted therapy and immunotherapy are changing the treatment landscape of soft tissue sarcoma.Chinese Clinical Oncology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - November 26, 2018 Category: Consumer Health News Tags: Hematology-Oncology Journal Article Source Type: news

Four-year-old was diagnosed with cancer after doctors dismissed his weeping eye as a cold  
Harri Cooke, from Tewkesbury, Gloucestershire, was a happy toddler before his mother, Carly, 33, noticed he had a weeping eye. He was later diagnosed with Ewing ’s Sarcoma (Source: the Mail online | Health)
Source: the Mail online | Health - November 21, 2018 Category: Consumer Health News Source Type: news

Woman ignored small lump in her stomach until it was a tumour the size of a baby 13 years later
WARNING: GRAPHIC CONTENT. Beverly Jaundrill, from Preston, had to support her heavy stomach lump with her hand until doctors diagnosed her with sarcoma, a form of cancer. (Source: the Mail online | Health)
Source: the Mail online | Health - November 21, 2018 Category: Consumer Health News Source Type: news

Four-year-old was diagnosed with cancer after doctors dismissed his weeping eye as a cold 
Harri Cooke, from Tewkesbury, Gloucestershire, was a happy toddler before his mum, Carly, 33, noticed he had a weeping eye. He was later diagnosed with Ewing’s Sarcoma (Source: the Mail online | Health)
Source: the Mail online | Health - November 21, 2018 Category: Consumer Health News Source Type: news

Man is forced to have his leg amputated after developing cancer
Matthew King, from North Yorkshire, was rushed to Darlington Memorial Hospital where he was diagnosed with Ewing Sarcoma -  a rare form of cancer that typically affects young men. (Source: the Mail online | Health)
Source: the Mail online | Health - November 20, 2018 Category: Consumer Health News Source Type: news

Man is forced to have his leg amputated after developing cancer
Matthew King, from North Yorkshire, was rushed to Darlington Memorial Hospital where he was diagnosed with Ewing Sarcoma - a rare form of cancer that typically affects young men. (Source: the Mail online | Health)
Source: the Mail online | Health - November 20, 2018 Category: Consumer Health News Source Type: news

Scientists develop potential new treatment for common soft-tissue childhood cancer
(Trinity College Dublin) CRISPR 'genetic screens' and new approaches to drug design have provided a potential new therapy, which blocks the progression of synovial sarcoma tumors in pre-clinical trials. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - November 20, 2018 Category: Cancer & Oncology Source Type: news

The HDAC3-SMARCA4-miR-27a axis promotes expression of the PAX3:FOXO1 fusion oncogene in rhabdomyosarcoma
Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma of childhood with an unmet clinical need for decades. A single oncogenic fusion gene is associated with treatment resistance and a 40 to 45% decrease in overall survival. We previously showed that expression of this PAX3:FOXO1 fusion oncogene in alveolar RMS (aRMS) mediates tolerance to chemotherapy and radiotherapy and that the class I–specific histone deacetylase (HDAC) inhibitor entinostat reduces PAX3:FOXO1 protein abundance. Here, we established the antitumor efficacy of entinostat with chemotherapy in various preclinical cell and mouse models and fou...
Source: Signal Transduction Knowledge Environment - November 20, 2018 Category: Science Authors: Bharathy, N., Berlow, N. E., Wang, E., Abraham, J., Settelmeyer, T. P., Hooper, J. E., Svalina, M. N., Ishikawa, Y., Zientek, K., Bajwa, Z., Goros, M. W., Hernandez, B. S., Wolff, J. E., Rudek, M. A., Xu, L., Anders, N. M., Pal, R., Harrold, A. P., Davies Tags: STKE Research Articles Source Type: news

Woman ignored small lump in her stomach until it was a tumour the size of a baby 13 years later
WARNING: GRAPHIC CONTENT. Beverly Jaundrill, from Preston, had to support her heavy stomach lump with her hand until doctors diagnosed her with sarcoma, a form of cancer. (Source: the Mail online | Health)
Source: the Mail online | Health - November 19, 2018 Category: Consumer Health News Source Type: news

Efficacy of Trabectedin in Elderly Patients With Sarcoma Efficacy of Trabectedin in Elderly Patients With Sarcoma
Elderly patients with good performance status benefit from trabectedin for soft tissue sarcoma similarly to younger patients.Annals of Oncology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - November 9, 2018 Category: Consumer Health News Tags: Hematology-Oncology Journal Article Source Type: news

French Study Reveals Potential Mesothelioma Treatment Target
A team of French researchers led by Dr. Christophe Blanquart has identified a substance that may better define the severity of malignant pleural mesothelioma (MPM) in the body and provide clues to more effectively manage the rare cancer. Brain-derived neurotrophic factor, as the name indicates, is a protein found in the brain. BDNF is a growth factor and also appears in other tissues in the body. “It seems that BDNF could be a prognostic marker for MPM patients,” Blanquart told The Mesothelioma Center at Asbestos.com. “The level of BDNF in pleural fluids could reflect the severity of disease.” The...
Source: Asbestos and Mesothelioma News - October 31, 2018 Category: Environmental Health Authors: Matt Mauney Source Type: news

Are We Underdosing Patients With Ewing Sarcoma?
A new study evaluated whether busulfan and melphalan improve EFS and OS when given after vincristine, ifosfamide, doxorubicin, and etoposide induction. (Source: CancerNetwork)
Source: CancerNetwork - October 25, 2018 Category: Cancer & Oncology Authors: John Schieszer Source Type: news

Advances of Systemic Treatment for Adult Soft-Tissue Sarcoma Advances of Systemic Treatment for Adult Soft-Tissue Sarcoma
Trabectedin and eribulin are showing promise for the treatment of soft tissue sarcoma.Chinese Clinical Oncology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - October 25, 2018 Category: Consumer Health News Tags: Hematology-Oncology Journal Article Source Type: news

Time to Rethink Chemo Doses in High-Risk, Localized Ewing Sarcoma?
A new study evaluated whether busulfan and melphalan improve EFS and OS when given after vincristine, ifosfamide, doxorubicin, and etoposide induction. (Source: CancerNetwork)
Source: CancerNetwork - October 23, 2018 Category: Cancer & Oncology Authors: John Schieszer Source Type: news

CAM Popular, but Cancer Patients Unaware of Risks CAM Popular, but Cancer Patients Unaware of Risks
Two studies involving sarcoma patients show that complementary and alternative medicine (CAM) treatments are popular, and most patients seem to be unconcerned about risks, such as interactions.Medscape Medical News (Source: Medscape Pharmacist Headlines)
Source: Medscape Pharmacist Headlines - October 12, 2018 Category: Drugs & Pharmacology Tags: Hematology-Oncology News Source Type: news

Alternative Therapies Popular With Sarcoma Patients
(MedPage Today) -- Drug-drug interactions still poorly understood (Source: MedPage Today Public Health)
Source: MedPage Today Public Health - October 11, 2018 Category: American Health Source Type: news

Trust in non-conventional therapies by cancer patients not matching awareness about risks
(European Society for Medical Oncology) Sarcoma patients show great openness to the use of complementary alternative medicines (CAMs) for supportive care, but they are poorly informed about safety issues and risk of interactions with anti-cancer drugs, a study to be presented at ESMO 2018 reported. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - October 9, 2018 Category: Cancer & Oncology Source Type: news

Big, Fat Tumors: Liposarcomas Can Top 70 Pounds
Sarcomas in the soft tissues (such as fat, nerves, ligaments, muscles) of all types are rare, accounting for less than 1% of all malignant tumors in adults. In 2018, the American Cancer Society estimates, about 13,000 new soft-tissue sarcomas of all types will be diagnosed, and about 5,000 Americans will die of them. (Source: WebMD Health)
Source: WebMD Health - October 5, 2018 Category: Consumer Health News Source Type: news

Study focused on improving radiation treatment for cancers in pet dogs
(UNC Lineberger Comprehensive Cancer Center) UNC Lineberger Comprehensive Cancer Center researchers and collaborators have been awarded a five-year, $3.2 million grant from the National Cancer Institute to investigate how to improve radiation treatment for pet dogs undergoing treatment for sarcoma. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - October 4, 2018 Category: Cancer & Oncology Source Type: news

Enhancing Cancer Immunotherapy with Artificial Intelligence
Physicians may soon use artificial intelligence (AI) and medical images to study tumors without a biopsy. The techniques developed to study tumors in this new way are described in the September 1 issue of The Lancet Oncology. Along with helping physicians learn more about tumors without surgery, the new approach should help identify which cancer patients will respond best to cutting-edge immunotherapy treatments. The AI techniques could be useful for “predicting clinical outcomes of patients treated with immunotherapy when validated by further prospective randomized trials,” the authors wrote. Immunotherapy tre...
Source: Asbestos and Mesothelioma News - September 19, 2018 Category: Environmental Health Authors: Matt Mauney Source Type: news

The Diagnosis and Management of Retroperitoneal Sarcoma
Retroperitoneal sarcoma is a rare tumor whose diagnosis and management can be challenging and for which management requires a multidisciplinary team. (Source: CancerNetwork)
Source: CancerNetwork - September 19, 2018 Category: Cancer & Oncology Authors: Sinziana Dumitra, MD, MSc, FRCSC, Alessandro Gronchi, MD Source Type: news

Brave eight-year-old boy battles second bout of brain cancer since he was just two
Jaxon Dugger, eight, from Hollis, Oklahoma, was fist diagnosed with Ewing sarcoma when he was just two years old. Three months after being declared cancer-free, his tumor returned. (Source: the Mail online | Health)
Source: the Mail online | Health - September 12, 2018 Category: Consumer Health News Source Type: news

Sarcoma-Associated Gene Fusions a Result of ‘Genome Chaos’
A study finds EWSR1-ETS in 42% of cases via complex, loop-like rearrangements, rather than by simple reciprocal translocations. (Source: CancerNetwork)
Source: CancerNetwork - September 11, 2018 Category: Cancer & Oncology Authors: Bryant Furlow Source Type: news

Immunotherapy may be efficacious in patients with HIV-associated Kaposi's sarcoma
(American Association for Cancer Research) Among a small cohort of patients with HIV-associated Kaposi's sarcoma treated with immune checkpoint inhibitors, more than 65 percent had partial or complete remission. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - September 7, 2018 Category: International Medicine & Public Health Source Type: news

Children's bone cancers could remain hidden for years before diagnosis
(Wellcome Trust Sanger Institute) Scientists have discovered that some childhood bone cancers start growing years before they are diagnosed. Researchers at the Wellcome Sanger Institute, UK and Hospital for Sick Children (SickKids), Canada discovered large-scale genetic rearrangements in Ewing Sarcomas and other children's cancers, and showed these can take years to form. The study in Science will help unravel causes of childhood cancers and could help find ways to diagnose and treat these cancers earlier in the future. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - August 30, 2018 Category: Cancer & Oncology Source Type: news

Rearrangement bursts generate canonical gene fusions in bone and soft tissue tumors
Sarcomas are cancers of the bone and soft tissue often defined by gene fusions. Ewing sarcoma involves fusions between EWSR1, a gene encoding an RNA binding protein, and E26 transformation-specific (ETS) transcription factors. We explored how and when EWSR1-ETS fusions arise by studying the whole genomes of Ewing sarcomas. In 52 of 124 (42%) of tumors, the fusion gene arises by a sudden burst of complex, loop-like rearrangements, a process called chromoplexy, rather than by simple reciprocal translocations. These loops always contained the disease-defining fusion at the center, but they disrupted multiple additional genes....
Source: ScienceNOW - August 30, 2018 Category: Science Authors: Anderson, N. D., de Borja, R., Young, M. D., Fuligni, F., Rosic, A., Roberts, N. D., Hajjar, S., Layeghifard, M., Novokmet, A., Kowalski, P. E., Anaka, M., Davidson, S., Zarrei, M., Id Said, B., Schreiner, L. C., Marchand, R., Sitter, J., Gokgoz, N., Brun Tags: Genetics, Medicine, Diseases, Online Only r-articles Source Type: news

New assay to detect genetic abnormalities in sarcomas outperforms conventional techniques
(Elsevier) A report in The Journal of Molecular Diagnostics describes a new assay, anchored multiplex PCR (AMP)-based targeted next-generation-sequencing (NGS), with superior diagnostic utility compared to conventional techniques. This includes the ability to analyze numerous target genes simultaneously and identify new fusion partners. In four cases, the assay diagnosed sarcoma in samples deemed falsely negative by conventional tests. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - August 20, 2018 Category: Cancer & Oncology Source Type: news