Are We Underdosing Patients With Ewing Sarcoma?
A new study evaluated whether busulfan and melphalan improve EFS and OS when given after vincristine, ifosfamide, doxorubicin, and etoposide induction. (Source: CancerNetwork)
Source: CancerNetwork - October 25, 2018 Category: Cancer & Oncology Authors: John Schieszer Source Type: news
Advances of Systemic Treatment for Adult Soft-Tissue Sarcoma Advances of Systemic Treatment for Adult Soft-Tissue Sarcoma
Trabectedin and eribulin are showing promise for the treatment of soft tissue sarcoma.Chinese Clinical Oncology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - October 25, 2018 Category: Consumer Health News Tags: Hematology-Oncology Journal Article Source Type: news
Time to Rethink Chemo Doses in High-Risk, Localized Ewing Sarcoma?
A new study evaluated whether busulfan and melphalan improve EFS and OS when given after vincristine, ifosfamide, doxorubicin, and etoposide induction. (Source: CancerNetwork)
Source: CancerNetwork - October 23, 2018 Category: Cancer & Oncology Authors: John Schieszer Source Type: news
CAM Popular, but Cancer Patients Unaware of Risks CAM Popular, but Cancer Patients Unaware of Risks
Two studies involving sarcoma patients show that complementary and alternative medicine (CAM) treatments are popular, and most patients seem to be unconcerned about risks, such as interactions.Medscape Medical News (Source: Medscape Pharmacist Headlines)
Source: Medscape Pharmacist Headlines - October 12, 2018 Category: Drugs & Pharmacology Tags: Hematology-Oncology News Source Type: news
Alternative Therapies Popular With Sarcoma Patients
(MedPage Today) -- Drug-drug interactions still poorly understood (Source: MedPage Today Public Health)
Source: MedPage Today Public Health - October 11, 2018 Category: American Health Source Type: news
Trust in non-conventional therapies by cancer patients not matching awareness about risks
(European Society for Medical Oncology) Sarcoma patients show great openness to the use of complementary alternative medicines (CAMs) for supportive care, but they are poorly informed about safety issues and risk of interactions with anti-cancer drugs, a study to be presented at ESMO 2018 reported. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - October 9, 2018 Category: Cancer & Oncology Source Type: news
Big, Fat Tumors: Liposarcomas Can Top 70 Pounds
Sarcomas in the soft tissues (such as fat, nerves, ligaments, muscles) of all types are rare, accounting for less than 1% of all malignant tumors in adults. In 2018, the American Cancer Society estimates, about 13,000 new soft-tissue sarcomas of all types will be diagnosed, and about 5,000 Americans will die of them. (Source: WebMD Health)
Source: WebMD Health - October 5, 2018 Category: Consumer Health News Source Type: news
Study focused on improving radiation treatment for cancers in pet dogs
(UNC Lineberger Comprehensive Cancer Center) UNC Lineberger Comprehensive Cancer Center researchers and collaborators have been awarded a five-year, $3.2 million grant from the National Cancer Institute to investigate how to improve radiation treatment for pet dogs undergoing treatment for sarcoma. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - October 4, 2018 Category: Cancer & Oncology Source Type: news
Enhancing Cancer Immunotherapy with Artificial Intelligence
Physicians may soon use artificial intelligence (AI) and medical images to study tumors without a biopsy.
The techniques developed to study tumors in this new way are described in the September 1 issue of The Lancet Oncology.
Along with helping physicians learn more about tumors without surgery, the new approach should help identify which cancer patients will respond best to cutting-edge immunotherapy treatments.
The AI techniques could be useful for “predicting clinical outcomes of patients treated with immunotherapy when validated by further prospective randomized trials,” the authors wrote.
Immunotherapy treatments ...
Source: Asbestos and Mesothelioma News - September 19, 2018 Category: Environmental Health Authors: Matt Mauney Source Type: news
The Diagnosis and Management of Retroperitoneal Sarcoma
Retroperitoneal sarcoma is a rare tumor whose diagnosis and management can be challenging and for which management requires a multidisciplinary team. (Source: CancerNetwork)
Source: CancerNetwork - September 19, 2018 Category: Cancer & Oncology Authors: Sinziana Dumitra, MD, MSc, FRCSC, Alessandro Gronchi, MD Source Type: news
Brave eight-year-old boy battles second bout of brain cancer since he was just two
Jaxon Dugger, eight, from Hollis, Oklahoma, was fist diagnosed with Ewing sarcoma when he was just two years old. Three months after being declared cancer-free, his tumor returned. (Source: the Mail online | Health)
Source: the Mail online | Health - September 12, 2018 Category: Consumer Health News Source Type: news
Sarcoma-Associated Gene Fusions a Result of ‘Genome Chaos’
A study finds EWSR1-ETS in 42% of cases via complex, loop-like rearrangements, rather than by simple reciprocal translocations. (Source: CancerNetwork)
Source: CancerNetwork - September 11, 2018 Category: Cancer & Oncology Authors: Bryant Furlow Source Type: news
Immunotherapy may be efficacious in patients with HIV-associated Kaposi's sarcoma
(American Association for Cancer Research) Among a small cohort of patients with HIV-associated Kaposi's sarcoma treated with immune checkpoint inhibitors, more than 65 percent had partial or complete remission. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - September 7, 2018 Category: International Medicine & Public Health Source Type: news
Children's bone cancers could remain hidden for years before diagnosis
(Wellcome Trust Sanger Institute) Scientists have discovered that some childhood bone cancers start growing years before they are diagnosed. Researchers at the Wellcome Sanger Institute, UK and Hospital for Sick Children (SickKids), Canada discovered large-scale genetic rearrangements in Ewing Sarcomas and other children's cancers, and showed these can take years to form. The study in Science will help unravel causes of childhood cancers and could help find ways to diagnose and treat these cancers earlier in the future. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - August 30, 2018 Category: Cancer & Oncology Source Type: news
Rearrangement bursts generate canonical gene fusions in bone and soft tissue tumors
Sarcomas are cancers of the bone and soft tissue often defined by gene fusions. Ewing sarcoma involves fusions between EWSR1, a gene encoding an RNA binding protein, and E26 transformation-specific (ETS) transcription factors. We explored how and when EWSR1-ETS fusions arise by studying the whole genomes of Ewing sarcomas. In 52 of 124 (42%) of tumors, the fusion gene arises by a sudden burst of complex, loop-like rearrangements, a process called chromoplexy, rather than by simple reciprocal translocations. These loops always contained the disease-defining fusion at the center, but they disrupted multiple additional genes....
Source: ScienceNOW - August 30, 2018 Category: Science Authors: Anderson, N. D., de Borja, R., Young, M. D., Fuligni, F., Rosic, A., Roberts, N. D., Hajjar, S., Layeghifard, M., Novokmet, A., Kowalski, P. E., Anaka, M., Davidson, S., Zarrei, M., Id Said, B., Schreiner, L. C., Marchand, R., Sitter, J., Gokgoz, N., Brun Tags: Genetics, Medicine, Diseases, Online Only r-articles Source Type: news
