Enhancing Cancer Immunotherapy with Artificial Intelligence
Physicians may soon use artificial intelligence (AI) and medical images to study tumors without a biopsy. The techniques developed to study tumors in this new way are described in the September 1 issue of The Lancet Oncology. Along with helping physicians learn more about tumors without surgery, the new approach should help identify which cancer patients will respond best to cutting-edge immunotherapy treatments. The AI techniques could be useful for “predicting clinical outcomes of patients treated with immunotherapy when validated by further prospective randomized trials,” the authors wrote. Immunotherapy treatments are helping some people survive cancers once considered a death sentence, including mesothelioma. Unfortunately, these therapies don’t work for everyone. The French researchers behind The Lancet study believe using AI to determine the effectiveness of immunotherapy is a welcome addition to the cancer treatment arsenal. “Development of new biomarkers that predict response to immunotherapy are needed,” the authors wrote. “Our study attempts to address this need by proposing a CT-based biomarker, which could be useful and accessible given the widespread availability and routine use of CT.” Putting CT Scans and Artificial Intelligence to Work in Cancer Care An important goal was to predict which tumors respond best to immunotherapy treatments, based only on features that can be discerned from a CT scan. The researchers firs...
Publication date: Available online 3 July 2020Source: American Journal of OtolaryngologyAuthor(s): Ali Safavi Naeini, Mahboobeh Karimi-Galougahi, Nasim Raad, Jahangir Ghorbani, Ayeh Taraghi, Sara Haseli, Golfam Mehrparvar, Mehrdad Bakhshayeshkaram
Conclusion. A combination of chemotherapy and MSC can yield to more favorable results in the treatment of HCC. PMID: 32617114 [PubMed]
Authors: Zhan LH, Dong YJ, Yang K, Lei SS, Li B, Teng X, Zhou C, Luo R, Yu QX, Jin HY, Lv GY, Chen SH Abstract Suanzaoren decoction (SZRT), a classic Chinese herbal prescription, has been used as a treatment for insomnia for more than a thousand years. However, recent studies have found no significant effects of SZRT as a treatment for insomnia caused by gastric discomfort. Herein, we studied the effects of modified Suanzaoren decoction (MSZRD) on gastrointestinal disorder-related insomnia. The main constituents of MSZRD were spinosin (2.21 mg/g) and 6-feruloylspinosin (0.78 mg/g). A pentobarbital-ind...
Isolation of Oxyberberine and β-Sitosterol from Berberis lycium Royle Root Bark Extract and In Vitro Cytotoxicity against Liver and Lung Cancer Cell Lines. Evid Based Complement Alternat Med. 2020;2020:2596082 Authors: Anwar MA, Tabassam S, Gulfraz M, Sheeraz Ahmad M, Raja GK, Arshad M Abstract Berberis lycium Royle has been traditionally used to cure rheumatism, eye and ear diseases, malarial fever, diabetes, stomach disorders, and skin diseases. There is a least amount of data available on cytotoxic capacity of Berberis lycium from Pakistani origin, so on this basis, the present study was aimed ...
Conclusions: Preoperative higher ALFF in the bilateral MCC and lower FC between the bilateral MCC and left calcarine were independently associated with the occurrence of DNR. The present fMRI study identified possible preoperative neuroimaging risk factors for DNR. This trial is registered with Chinese Clinical Trial Registry ChiCTR-DCD-15006096. PMID: 32617099 [PubMed - in process]
Publication date: Available online 3 July 2020Source: Journal of Trace Elements in Medicine and BiologyAuthor(s): B. Toubhans, A.T Gourlan, P. Telouk, K. Lutchman-Singh, L.W. Francis, R.S. Conlan, L. Margarit, D. Gonzalez, L. Charlet
Publication date: 15 October 2020Source: Sensors and Actuators B: Chemical, Volume 321Author(s): Han Wei, Yifang Yu, Yueqin Wang, Zhenzhen Ying, Weiyan Cheng, Xin Tian, Quancheng Kan
Authors: Wongsaengsak S, Quirch M, Ball S, Sultan A, Jahan N, Elmassry M, Rehman S Abstract Docetaxel is an anti-microtubule agent and a highly effective treatment of locally advanced and metastatic breast cancer. There are several adverse effects associated with docetaxel, such as myelosuppression, peripheral neuropathy, fluid retention, and asthenia. One of the most well-known side-effects of this medication is mild to moderate myalgia. Here, we report a case of a 49-year-old female with stage 3 breast cancers who developed severe acute myositis following docetaxel use. The mechanism of docetaxel-induced myositis...
Publication date: Available online 4 July 2020Source: European UrologyAuthor(s): Carissa E. Chu, Peter E Lonergan, Samuel L. Washington, Janet E Cowan, Katsuto Shinohara, Antonio C. Westphalen, Peter R. Carroll, Matthew R Cooperberg
Publication date: Available online 4 July 2020Source: European UrologyAuthor(s): Andrew Vickers, Sigrid V. Carlsson, Matthew Cooperberg
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