New drug seeks receptors in sarcoma cells, attacks tumors in animal trials
(University of Illinois at Urbana-Champaign) A new compound that targets a receptor within sarcoma cancer cells shrank tumors and hampered their ability to spread in mice and pigs, a study from researchers at the University of Illinois reports.The researchers conducted a multi-year, cross-disciplinary study that went from screening potential drug candidates to identifying and synthesizing one compound, to packaging it into nanoparticles for delivery in cells, to testing it in cell cultures and finally in mice and pigs with sarcoma tumors. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - December 13, 2018 Category: Cancer & Oncology Source Type: news
Utility of Genomic Profiling in Treating Advanced Sarcomas Utility of Genomic Profiling in Treating Advanced Sarcomas
Molecular profiling may be particularly useful in guiding therapy of sarcoma with an unclear diagnosis or rare subtype.JCO Precision Oncology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - December 10, 2018 Category: Consumer Health News Tags: Hematology-Oncology Journal Article Source Type: news
LZTR1 is a regulator of RAS ubiquitination and signaling
In genetic screens aimed at understanding drug resistance mechanisms in chronic myeloid leukemia cells, inactivation of the cullin 3 adapter protein-encoding leucine zipper-like transcription regulator 1 (LZTR1) gene led to enhanced mitogen-activated protein kinase (MAPK) pathway activity and reduced sensitivity to tyrosine kinase inhibitors. Knockdown of the Drosophila LZTR1 ortholog CG3711 resulted in a Ras-dependent gain-of-function phenotype. Endogenous human LZTR1 associates with the main RAS isoforms. Inactivation of LZTR1 led to decreased ubiquitination and enhanced plasma membrane localization of endogenous KRAS (V...
Source: ScienceNOW - December 6, 2018 Category: Science Authors: Bigenzahn, J. W., Collu, G. M., Kartnig, F., Pieraks, M., Vladimer, G. I., Heinz, L. X., Sedlyarov, V., Schischlik, F., Fauster, A., Rebsamen, M., Parapatics, K., Blomen, V. A., Müller, A. C., Winter, G. E., Kralovics, R., Brummelkamp, T. R., Mlod Tags: Cell Biology, Medicine, Diseases reports Source Type: news
Medical News Today: Does HIV increase cancer risk?
HIV can weaken a person ’s immune system, which can increase the risk of certain types of cancer. Such cancers include Kaposi’s sarcoma, non-Hodgkin lymphoma, and cervical, lung, anal, and oral cancer. However, effective treatment can significantly reduce the risk of developing these cancers. Learn more here. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - December 4, 2018 Category: Consumer Health News Tags: HIV and AIDS Source Type: news
Next Frontiers in Systemic Therapy for Soft Tissue Sarcoma Next Frontiers in Systemic Therapy for Soft Tissue Sarcoma
Molecularly targeted therapy and immunotherapy are changing the treatment landscape of soft tissue sarcoma.Chinese Clinical Oncology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - November 26, 2018 Category: Consumer Health News Tags: Hematology-Oncology Journal Article Source Type: news
Four-year-old was diagnosed with cancer after doctors dismissed his weeping eye as a cold
Harri Cooke, from Tewkesbury, Gloucestershire, was a happy toddler before his mother, Carly, 33, noticed he had a weeping eye. He was later diagnosed with Ewing ’s Sarcoma (Source: the Mail online | Health)
Source: the Mail online | Health - November 21, 2018 Category: Consumer Health News Source Type: news
Woman ignored small lump in her stomach until it was a tumour the size of a baby 13 years later
WARNING: GRAPHIC CONTENT. Beverly Jaundrill, from Preston, had to support her heavy stomach lump with her hand until doctors diagnosed her with sarcoma, a form of cancer. (Source: the Mail online | Health)
Source: the Mail online | Health - November 21, 2018 Category: Consumer Health News Source Type: news
Four-year-old was diagnosed with cancer after doctors dismissed his weeping eye as a cold
Harri Cooke, from Tewkesbury, Gloucestershire, was a happy toddler before his mum, Carly, 33, noticed he had a weeping eye. He was later diagnosed with Ewing’s Sarcoma (Source: the Mail online | Health)
Source: the Mail online | Health - November 21, 2018 Category: Consumer Health News Source Type: news
Man is forced to have his leg amputated after developing cancer
Matthew King, from North Yorkshire, was rushed to Darlington Memorial Hospital where he was diagnosed with Ewing Sarcoma - a rare form of cancer that typically affects young men. (Source: the Mail online | Health)
Source: the Mail online | Health - November 20, 2018 Category: Consumer Health News Source Type: news
Man is forced to have his leg amputated after developing cancer
Matthew King, from North Yorkshire, was rushed to Darlington Memorial Hospital where he was diagnosed with Ewing Sarcoma - a rare form of cancer that typically affects young men. (Source: the Mail online | Health)
Source: the Mail online | Health - November 20, 2018 Category: Consumer Health News Source Type: news
Scientists develop potential new treatment for common soft-tissue childhood cancer
(Trinity College Dublin) CRISPR 'genetic screens' and new approaches to drug design have provided a potential new therapy, which blocks the progression of synovial sarcoma tumors in pre-clinical trials. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - November 20, 2018 Category: Cancer & Oncology Source Type: news
The HDAC3-SMARCA4-miR-27a axis promotes expression of the PAX3:FOXO1 fusion oncogene in rhabdomyosarcoma
Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma of childhood with an unmet clinical need for decades. A single oncogenic fusion gene is associated with treatment resistance and a 40 to 45% decrease in overall survival. We previously showed that expression of this PAX3:FOXO1 fusion oncogene in alveolar RMS (aRMS) mediates tolerance to chemotherapy and radiotherapy and that the class I–specific histone deacetylase (HDAC) inhibitor entinostat reduces PAX3:FOXO1 protein abundance. Here, we established the antitumor efficacy of entinostat with chemotherapy in various preclinical cell and mouse models and fou...
Source: Signal Transduction Knowledge Environment - November 20, 2018 Category: Science Authors: Bharathy, N., Berlow, N. E., Wang, E., Abraham, J., Settelmeyer, T. P., Hooper, J. E., Svalina, M. N., Ishikawa, Y., Zientek, K., Bajwa, Z., Goros, M. W., Hernandez, B. S., Wolff, J. E., Rudek, M. A., Xu, L., Anders, N. M., Pal, R., Harrold, A. P., Davies Tags: STKE Research Articles Source Type: news
Woman ignored small lump in her stomach until it was a tumour the size of a baby 13 years later
WARNING: GRAPHIC CONTENT. Beverly Jaundrill, from Preston, had to support her heavy stomach lump with her hand until doctors diagnosed her with sarcoma, a form of cancer. (Source: the Mail online | Health)
Source: the Mail online | Health - November 19, 2018 Category: Consumer Health News Source Type: news
Efficacy of Trabectedin in Elderly Patients With Sarcoma Efficacy of Trabectedin in Elderly Patients With Sarcoma
Elderly patients with good performance status benefit from trabectedin for soft tissue sarcoma similarly to younger patients.Annals of Oncology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - November 9, 2018 Category: Consumer Health News Tags: Hematology-Oncology Journal Article Source Type: news
French Study Reveals Potential Mesothelioma Treatment Target
A team of French researchers led by Dr. Christophe Blanquart has identified a substance that may better define the severity of malignant pleural mesothelioma (MPM) in the body and provide clues to more effectively manage the rare cancer.
Brain-derived neurotrophic factor, as the name indicates, is a protein found in the brain. BDNF is a growth factor and also appears in other tissues in the body.
“It seems that BDNF could be a prognostic marker for MPM patients,” Blanquart told The Mesothelioma Center at Asbestos.com. “The level of BDNF in pleural fluids could reflect the severity of disease.”
The study was publi...
Source: Asbestos and Mesothelioma News - October 31, 2018 Category: Environmental Health Authors: Matt Mauney Source Type: news
