Primary proximal epithelioid sarcoma of the lung: A case report and review of the literature
We reported a case of primary pulmonary ES and reviewed the literature to summarize its clinicopathological features. A 51-year-old man presented with hemoptysis and cough. Chest computed tomography (CT) showed a nodule located in the apical and posterior segments of the left upper lobe of the lung. The patient underwent a lobectomy, and a pathologic diagnosis of epithelioid sarcoma was made. Histologically, most tumors are composed of epithelioid cells with evidence of bidirectional expression of epithelium and mesenchyma. The SMARCB1 stain of tumor cells was negative, and a pathogenic mutation of SMARCB1 p.E115* (exon 3)...
Source: Histology and Histopathology - March 31, 2023 Category: Cytology Authors: Jiayu Li Yehan Zhou Yang Liu Source Type: research

Quality measurement for soft tissue sarcomas in Germany – first results of the Certified Sarcoma Centres
Conclusions: A sarcoma-specific quality assurance scheme that includes guideline-derived quality indicators was developed. In future, a broader database will allow further insights into sarcoma care in Germany. (Source: Oncology Research and Treatment)
Source: Oncology Research and Treatment - March 31, 2023 Category: Cancer & Oncology Source Type: research

Case report: Primary pleural giant extraskeletal Ewing sarcoma in a child
This study presents the case of an 11-year-old boy who presented to our hospital with no apparent cause of left shoulder pain for 6 months. On physical examination, tenderness was noted in the left chest wall and shoulder joint, which had a limited range of motion. Computed tomography (CT) and magnetic resonance imaging (MRI) of the chest revealed an irregular soft tissue mass in the upper left thorax, with a wide base attached to the adjacent pleura and bone destruction of the adjacent left first rib. The patient’s bone scan showed a dense focus of increased radiotracer accumulation in the left first rib. A subsequent C...
Source: Frontiers in Oncology - March 31, 2023 Category: Cancer & Oncology Source Type: research

Cancers, Vol. 15, Pages 2099: Targeting the Molecular and Immunologic Features of Leiomyosarcoma
ise F. Nassif Leiomyosarcoma (LMS) is a rare, aggressive mesenchymal tumor with smooth muscle differentiation. LMS is one of the most common histologic subtypes of soft tissue sarcoma; it most frequently occurs in the extremities, retroperitoneum, or uterus. LMS often demonstrates aggressive tumor biology, with a higher risk of developing distant metastatic disease than most sarcoma histologic types. The prognosis is poor, particularly in patients with uterine disease, and there is a need for the development of more effective therapies. Genetically, LMS is karyotypically complex and characterized by a low tumor mutatio...
Source: Cancers - March 31, 2023 Category: Cancer & Oncology Authors: Brandon M. Cope Raymond S. Traweek Rossana Lazcano Emily Z. Keung Alexander J. Lazar Christina L. Roland Elise F. Nassif Tags: Review Source Type: research

Oncostatin M and Nivolumab Affect the Cytotoxic T-Cell Proportions and the Susceptibility to TRAIL-Induced Death in Non-Leukocyte Cell Subpopulations in Soft Tissue Sarcomas
Conclusion: In conclusion, the biological efficacy of OSM is reflected in the tumor microenvironment rather than in the peripheral blood of the patients in our cohort, and nivolumab could potentiate its mechanism of action in selected cases. Nevertheless, more histotype-tailored studies are needed to fully understand the functions of OSM in STSs.Pharmacology (Source: Pharmacology)
Source: Pharmacology - March 30, 2023 Category: Drugs & Pharmacology Source Type: research

Primary Effusion Lymphoma in an HIV-Negative Patient with Chronic Myeloid Leukemia Treated with Dasatinib
We report a case of PEL in a young, relatively immunocompetent patient with no history of organ transplant receiving dasatinib for CML, BCR::ABL1-positive. Discussion: We hypothesize that the loss of T-cell function secondary to TKI therapy (dasatinib) may have resulted in the unchecked cellular proliferation of KSHV-infected cells, leading to the emergence of a PEL. We recommend cytologic investigation and KSHV testing in patients being treated with dasatinib for CML who present with persistent or recurrent effusions. (Source: Pathobiology)
Source: Pathobiology - March 30, 2023 Category: Pathology Source Type: research

Emergence of SARS ‐CoV‐2 spike protein at the vaccination site
ConclusionsHistiocytic cells and fibrocytes are the heralds of spike protein synthesis at the vaccination site. The underlying cause of this apparent cell specifity is unknown. This needs to be investigated in future experiments, for example in an animal model. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - March 30, 2023 Category: Allergy & Immunology Authors: Annika Beck, Hanna Dietenberger, Sebastian N. Kunz, Kevin Mellert, Peter M öller Tags: SHORT REPORT Source Type: research

Integration analysis based on fatty acid metabolism robustly predicts prognosis, dissecting immunity microenvironment and aiding immunotherapy for soft tissue sarcoma
Conclusion: Altogether, our work comprehensively and systematically clarifies fatty acid metabolism’s potential roles and clinical significance in STS. The novel individualized score based on fatty acid metabolism may be provided as a potential marker and treatment strategy in STS. (Source: Frontiers in Genetics)
Source: Frontiers in Genetics - March 30, 2023 Category: Genetics & Stem Cells Source Type: research

Cancers, Vol. 15, Pages 2050: Pediatric Patients with Stage IV Rhabdomyosarcoma Significantly Benefit from Long-Term Maintenance Therapy: Results of the CWS-IV 2002 and the CWS DOK IV 2004-Trials
In conclusion, our data suggest that in patients suffering from metastatic RMS, long-term maintenance therapy is a superior strategy in terms of EFS and OS compared to alloHSCT. EFS and OS of HDCT are similar in these strategies; however, the therapeutic burden of LTMT is much lower. (Source: Cancers)
Source: Cancers - March 30, 2023 Category: Cancer & Oncology Authors: Lars Tramsen Konrad Bochennek Monika Sparber-Sauer Emilia Salzmann-Manrique Monika Scheer Tobias Dantonello Arndt Borkhardt Uta Dirksen Anne Thorwarth Jeanette Greiner Martin Ebinger Jadwiga Weclawek-Tompol Ruth Ladenstein Gustaf Ljungman Erika Hallmen Th Tags: Article Source Type: research

A case of acute ischemic stroke caused by doxorubicin-induced cardiomyopathy in a patient with synovial sarcoma
(Source: Acta Neurologica Belgica)
Source: Acta Neurologica Belgica - March 30, 2023 Category: Neurology Source Type: research

The added value of the visual analysis of DWI in post-surgery follow-up of soft tissue sarcoma of the extremities: do we really need ADC?
ConclusionsIn this highly heterogeneous group of tumors, the role of ADC seems to be limited. Based on our experience, looking at DWI images makes the lesions promptly and easily detectable. This technique gives less deceptive findings making the reader more confident in detecting/excluding tumoral tissue; the main drawback is the image quality and the lack of standardization. (Source: La Radiologia Medica)
Source: La Radiologia Medica - March 30, 2023 Category: Radiology Source Type: research

Downregulated annexin A1 expression correlates with poor prognosis, metastasis, and immunosuppressive microenvironment in Ewing's sarcoma
CONCLUSIONS: ANXA1 may serve as an independent prognostic biomarker for ES patients and is associated with metastasis and the immunosuppressive microenvironment in ES, which needs to be validated in further studies.PMID:36988561 | DOI:10.18632/aging.204615 (Source: Aging)
Source: Aging - March 29, 2023 Category: Biomedical Science Authors: Xiangwen Shi Yipeng Wu Linmeng Tang Haonan Ni Yongqing Xu Source Type: research

Histologic transformation of follicular lymphoma: pathologists' viewpoint
J Clin Exp Hematop. 2023;63(1):12-18. doi: 10.3960/jslrt.22046.ABSTRACTOutcomes of patients with histologic transformation (HT) of follicular lymphoma (FL) have been believed to be poor. The most common histologic subtype of transformation from FL is diffuse large B-cell lymphoma (DLBCL), which accounts for 90% of the cases, and the remaining 10% of the cases include classic Hodgkin lymphoma, high-grade B-cell lymphoma, plasmablastic lymphoma, B-acute lymphoblastic leukemia/lymphoma, histiocytic/dendritic cell sarcoma, and anaplastic large cell lymphoma-like lymphoma. Because the histologic criteria for the diagnosis of DL...
Source: Journal of Clinical and Experimental Hematopathology : JCEH - March 29, 2023 Category: Hematology Authors: Akiko Miyagi Maeshima Source Type: research

Endometrial stromal sarcoma: French Guidelines from the French Sarcoma Group and the Rare Malignant Gynecologic Tumors Group
Bull Cancer. 2023 Mar 27:S0007-4551(23)00141-8. doi: 10.1016/j.bulcan.2023.03.003. Online ahead of print.ABSTRACTLow-grade endometrial stromal sarcoma (LG-ESS) accounts for approximately 15% of all uterine sarcomas. Median age of patients is around 50 years and half of the patients are premenopausal. In all, 60% of cases present with FIGO stage I disease. Preoperatively radiologic findings of ESS are not specific. Pathological diagnosis remains essential. This review aimed to present the French guidelines for low grade ESS treatment within the Groupe sarcome français - Groupe d'étude des tumeurs osseuse (GSF-GETO)/NETSAR...
Source: Bulletin du Cancer - March 29, 2023 Category: Cancer & Oncology Authors: Coriolan Lebreton Pierre Meeus Catherine Genestie Sabrina Croce Fr édéric Guyon Carmen Llacer Moscardo Sophie Taieb Jean-Yves Blay Sylvie Bonvalot Emmanuelle Bompas Christine Chevreau Fabrice L écuru L éa Rossi Florence Joly Maria Rios Lo ïc Chaignea Source Type: research

Predictive value of peripheral blood markers in soft tissue sarcoma patients treated with eribulin
CONCLUSIONS: the combined indicator of low NLR prestart and high ALC8D predicted the survival of patients treated with eribulin as well as the histology of L-sarcoma. Though further validation was needed, this finding would provide valuable prognostic factor that help treatment decision in the absence of consensus on the optimal second-line therapy following doxorubicin treatment in STS patients.PMID:36989466 | DOI:10.1093/jjco/hyad021 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - March 29, 2023 Category: Cancer & Oncology Authors: Shin Ishihara Koichi Ogura Aiko Maeshima Tatsunori Shimoi Kazuki Sudo Yuki Kojima Suguru Fukushima Shuhei Osaki Eisuke Kobayashi Shintaro Iwata Yoshiyuki Matsui Kan Yonemori Akira Kawai Source Type: research