Stemness and Cell Cycle Regulators and Their Modulation by Retinoic Acid in Ewing Sarcoma
Curr Issues Mol Biol. 2024 Apr 26;46(5):3990-4003. doi: 10.3390/cimb46050246.ABSTRACTRetinoic acid (RA) regulates stemness and differentiation in human embryonic stem cells (ESCs). Ewing sarcoma (ES) is a pediatric tumor that may arise from the abnormal development of ESCs. Here we show that RA impairs the viability of SK-ES-1 ES cells and affects the cell cycle. Cells treated with RA showed increased levels of p21 and its encoding gene, CDKN1A. RA reduced mRNA and protein levels of SRY-box transcription factor 2 (SOX2) as well as mRNA levels of beta III Tubulin (TUBB3), whereas the levels of CD99 increased. Exposure to RA...
Source: Mol Biol Cell - May 24, 2024 Category: Molecular Biology Authors: Maria Eduarda Battistella Nat ália Hogetop Freire Bruno Toson Matheus Dalmolin Marcelo A C Fernandes Isadora D Tassinari Mariane Jaeger Andr é T Brunetto Algemir L Brunetto Lauro Gregianin Caroline Brunetto de Farias Rafael Roesler Source Type: research

A Two-Step Approach to the Surgical Treatment of Soft-Tissue Sarcomas
Conclusions: Two-step surgery represents the most suitable solution to allow surgical radicality with minimal recurrency and adequate soft-tissue reconstruction, avoiding the possibility of wasting autologous tissue. Our patients generally embraced this approach and the management that followed.PMID:38785494 | DOI:10.3390/curroncol31050213 (Source: Current Oncology)
Source: Current Oncology - May 24, 2024 Category: Cancer & Oncology Authors: Camillo Fulchignoni Luigi Cianni Maria Rosaria Matrangolo Mariagrazia Cerrone Francesco Cavola Elisabetta Pataia Raffaele Vitiello Giulio Maccauro Pasquale Farsetti Giuseppe Rovere Source Type: research

Molecular mechanisms of human papilloma virus related skin cancers: A review
Medicine (Baltimore). 2024 May 24;103(21):e38202. doi: 10.1097/MD.0000000000038202.ABSTRACTThe human papillomavirus (HPV) belongs to the Papillomaviridae family of viruses which includes small, double-stranded DNA viral agents. Approximately 90% of HPV infections occur asymptomatically and resolve spontaneously. However, infection with high-risk viral strains can lead to the development of preneoplastic lesions, with an increased propensity to become cancerous. The location of these malignancies includes the oral cavity, cervix, vagina, anus, and vulva, among others. The role of HPV in carcinogenesis has already been demon...
Source: Herpes - May 24, 2024 Category: Infectious Diseases Authors: Elena-Codruta Cozma Laura M ădălina Banciu Ana Maria Celarel Elena Soare Bahadar S Srichawla Vincent Kipkorir Mihnea-Alexandru G ăman Source Type: research

GSE208367 COMPASS complex inhibition targets the metastasis initiating cell in undifferentiated pleomorphic sarcoma
Contributors : Aenjamin Alman ; Joy Ban ; Vijitha Puviindran ; Yuning J TangSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencing ; OtherOrganism : Mus musculusThis SuperSeries is composed of the SubSeries listed below. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - May 24, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Genome binding/occupancy profiling by high throughput sequencing Other Mus musculus Source Type: research

GSE208366 Whole genome sequencing of mouse sarcoma clones
Contributors : Yuning J Tang ; Jianhong Ou ; Benjamin AlmanSeries Type : OtherOrganism : Mus musculusWhole genome sequencing of mouse sarcoma clones (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - May 24, 2024 Category: Genetics & Stem Cells Tags: Other Mus musculus Source Type: research

GSE208365 Identify H3K4Me3 occupancy on genome in Setd1a Knock out (KO) mouse undifferentiated pleomorphic sarcoma cells
Contributors : Jianhong Ou ; Benjamin AlmanSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusAs Setd1a is a methyltransferase targeting H3K4, we performed H3K4Me3 ChIP in control and Setd1a KO cell to observe the effects of Setd1a on H3K4Me3.Chromatin immunoprecipitation DNA-sequencing (ChIP-seq) for H3K4Me in control mouse UPS and Setd1a KO mouse UPS cells . (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - May 24, 2024 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Mus musculus Source Type: research

GSE208363 Effect of depletion of Setd1a on gene expression in mouse Undifferentiated Pleomorphic Sarcoma (UPS)
Contributors : Ga I Ban ; Yu Xiang ; Benjamin AlmanSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo investigate the Setd1a function in the regulation of lung metastasis formation, we established mouse UPS cell lines in which each target gene has been knocked down by shRNA.We then performed gene expression profiling analysis using data obtained from RNA-seq (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - May 24, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

Promoting psychological support services for parents of children with sarcoma through health-social partnership: A quality improvement project
A significant portion of parents of children diagnosed with sarcoma experience excessive stress and anxiety disorder. This quality improvement project aimed to implement a psychological support service program tailored for parents of children with sarcoma and evaluate its effects. (Source: Journal of Pediatric Nursing)
Source: Journal of Pediatric Nursing - May 24, 2024 Category: Nursing Authors: Li Peng, Sha-sha Xiong, Juan Li, Mian Wang, Frances Kam Yuet Wong Source Type: research

Novel Definitive Hypofractionated Accelerated Radiation Dose-painting (HARD) for Unresected Soft Tissue Sarcomas
CONCLUSIONS: The HARD regimen is a safe method of dose-escalating STS, with durable 3-year locoregional control. This approach is a promising alternative for unresected STS, though further follow-up is required to determine long-term control and toxicity.PMID:38778821 | PMC:PMC11110037 | DOI:10.1016/j.adro.2024.101447 (Source: Cancer Control)
Source: Cancer Control - May 23, 2024 Category: Cancer & Oncology Authors: John Michael Bryant Matthew N Mills George Q Yang Casey Liveringhouse Russell Palm Peter A Johnstone Justin T Miller Kujtim Latifi Vladimir Feygelman Arash O Naghavi Source Type: research

Immune Deficiency/Dysregulation Associated Lymphoid Proliferations, EBV+ In Persons Living With HIV
CONCLUSION: IDD-associated-lymphoid-proliferations EBV+ occured in severely immunosuppressed HIV+ patients, a high percentage of whom had concomitant Kaposi sarcoma. The prognosis was good in patients treated only with ART.PMID:38781946 | DOI:10.24875/RIC.24000006 (Source: Herpes)
Source: Herpes - May 23, 2024 Category: Infectious Diseases Authors: Johanna Cevallos Carmen Lome-Maldonado Leticia Quintanilla-Mart ínez Ivonne Montes-Mojarro Beda Islas-Mu ñoz Ana F Ram írez Leslie Chavez-Gal án Lucero Ram ón-Luing Patricia Volkow Source Type: research

Oxford Spine Buddies: an acceptability and feasibility project for peer-to-peer support in a spine sarcoma service
CONCLUSION: The project was well received and preliminary data are encouraging. Therefore, due to early findings from the first participants, the service is continuing to roll out the buddy programme.PMID:38780977 | DOI:10.12968/bjon.2024.33.10.S16 (Source: British Journal of Nursing)
Source: British Journal of Nursing - May 23, 2024 Category: Nursing Authors: Jasmine Cammas Sheto Tomy Louise Strickland Gerard Mawhinney Source Type: research

Development and benchmarking of a Deep Learning-based MRI-guided gross tumor segmentation algorithm for Radiomics analyses in extremity soft tissue sarcomas
CONCLUSION: The results demonstrate that the DLBAS algorithm provides reproducible VOI predictions for radiomics feature extraction. Variability remains regarding direct clinical applicability of predictions for RT treatment planning.PMID:38782301 | DOI:10.1016/j.radonc.2024.110338 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 23, 2024 Category: Radiology Authors: Jan C Peeken Lucas Etzel Tim Tomov Stefan M ünch Lars Sch üttrumpf Julius H Shaktour Johannes Kiechle Carolin Knebel Stephanie K Schaub Nina A Mayr Henry C Woodruff Philippe Lambin Alexandra S Gersing Denise Bernhardt Matthew J Nyflot Bjoern Menze Steph Source Type: research

Sphingosine is involved in PAPTP-induced death of pancreas cancer cells by interfering with mitochondrial functions
J Mol Med (Berl). 2024 May 23. doi: 10.1007/s00109-024-02456-2. Online ahead of print.ABSTRACTPancreas ductal adenocarcinoma belongs to the most common cancers, but also to the tumors with the poorest prognosis. Here, we pharmacologically targeted a mitochondrial potassium channel, namely mitochondrial Kv1.3, and investigated the role of sphingolipids and mutated Kirsten Rat Sarcoma Virus (KRAS) in Kv1.3-mediated cell death. We demonstrate that inhibition of Kv1.3 using the Kv1.3-inhibitor PAPTP results in an increase of sphingosine and superoxide in membranes and/or membranes associated with mitochondria, which is enhance...
Source: Molecular Medicine - May 23, 2024 Category: Molecular Biology Authors: Sameer H Patel Gregory C Wilson Yuqing Wu Simone Keitsch Barbara Wilker Andrea Mattarei Syed A Ahmad Ildiko Szabo Erich Gulbins Source Type: research

Immune Deficiency/Dysregulation Associated Lymphoid Proliferations, EBV+ In Persons Living With HIV
CONCLUSION: IDD-associated-lymphoid-proliferations EBV+ occured in severely immunosuppressed HIV+ patients, a high percentage of whom had concomitant Kaposi sarcoma. The prognosis was good in patients treated only with ART.PMID:38781946 | DOI:10.24875/RIC.24000006 (Source: Herpes)
Source: Herpes - May 23, 2024 Category: Infectious Diseases Authors: Johanna Cevallos Carmen Lome-Maldonado Leticia Quintanilla-Mart ínez Ivonne Montes-Mojarro Beda Islas-Mu ñoz Ana F Ram írez Leslie Chavez-Gal án Lucero Ram ón-Luing Patricia Volkow Source Type: research

Oxford Spine Buddies: an acceptability and feasibility project for peer-to-peer support in a spine sarcoma service
CONCLUSION: The project was well received and preliminary data are encouraging. Therefore, due to early findings from the first participants, the service is continuing to roll out the buddy programme.PMID:38780977 | DOI:10.12968/bjon.2024.33.10.S16 (Source: British Journal of Nursing)
Source: British Journal of Nursing - May 23, 2024 Category: Nursing Authors: Jasmine Cammas Sheto Tomy Louise Strickland Gerard Mawhinney Source Type: research