Thrombus or tumor? A case report of a rare sarcoma entity: intimal sarcoma of the pulmonary arteries
CONCLUSION: In case of atypical presentation of a pulmonary embolism, a tumor originating from the great vessels should be considered. Molecular pathology techniques support in establishing a reliable diagnosis.PMID:38656400 | DOI:10.1007/s11033-024-09467-9 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 24, 2024 Category: Molecular Biology Authors: A D örr A Fl örcken L Bullinger D Capper A Von Deimling D Kaul S M ärdian C Starck D Horst M P Dragomir F M Sch äfer A Jarosch Source Type: research
Significance of radiation therapy in the myxoid round-cell liposarcoma treatment regimen
ConclusionPreoperative radiation therapy for myxoid liposarcoma near vital organs is a good approach because even with a reduced dose of 40 Gy, significant tumor reduction and excellent results were achieved. Definitive radiation therapy is the recommended treatment for older patients with serious comorbidities or inoperable patients. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - April 24, 2024 Category: Cancer & Oncology Source Type: research
Molecular Heterogeneity in Leiomyosarcoma and Implications for Personalised Medicine
Opinion statementLeiomyosarcoma (LMS) is one of the more common subtypes of soft tissue sarcomas (STS), accounting for about 20% of cases. Differences in anatomical location, risk of recurrence and histomorphological variants contribute to the substantial clinical heterogeneity in survival outcomes and therapy responses observed in patients. There is therefore a need to move away from the current one-size-fits-all treatment approach towards a personalised strategy tailored for individual patients. Over the past decade, tissue profiling studies have revealed key genomic features and an additional layer of molecular heteroge...
Source: Current Treatment Options in Oncology - April 24, 2024 Category: Cancer & Oncology Source Type: research
Short- and long-term post-nephrectomy outcomes for retroperitoneal liposarcoma from a high-volume sarcoma center: a propensity score matching analysis
CONCLUSIONS: RLPS resection with nephrectomy is related to a mild progression of renal impairment; however, dialysis is rare. En bloc nephrectomy for complete resection of RLPS is safe and improves local control.PMID:38652434 | DOI:10.1007/s10147-024-02530-2 (Source: Cancer Control)
Source: Cancer Control - April 23, 2024 Category: Cancer & Oncology Authors: Guoqiang Xue Zhen Wang Bonan Liu Chengpeng Li Ang Lv Xiuyun Tian Jianhui Wu Hui Qiu Chunyi Hao Source Type: research
Partially Ablative Body Radiotherapy (PABR): A novel approach for palliative radiotherapy of locally advanced bulky unresectable sarcomas
Radiother Oncol. 2024 Apr 21:110275. doi: 10.1016/j.radonc.2024.110275. Online ahead of print.NO ABSTRACTPMID:38653378 | DOI:10.1016/j.radonc.2024.110275 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 23, 2024 Category: Radiology Authors: Kelvin Ken Yu Adam Yeo Samuel Ngan Julie Chu David Chang Shankar Siva Aaron Wong Tomas Kron Nick Hardcastle Mathieu Gaudreault Therese Chesson Siena Williams Mark Burns Sarat Chander Source Type: research
Disparities in incidence and survival for patients with Ewing sarcoma in Florida
ConclusionsFlorida Hispanic males have a higher-than-expected incidence of osseous ES compared to the US. Hispanics of both sexes show remarkably worse survival for nonmetastatic disease compared to NHW. This disparity is likely multifactorial and requires further in-depth studies. (Source: Cancer Medicine)
Source: Cancer Medicine - April 23, 2024 Category: Cancer & Oncology Authors: Aditi Dhir,
Rachna Rahul,
Qinran Liu,
Dan Pham,
Rachel Kronenfeld,
Tulay Koru ‐Sengul,
Paulo S. Pinheiro Tags: RESEARCH ARTICLE Source Type: research
Clinical management of TP53 mosaic variants found on germline genetic testing
Diagnosis of Li-Fraumeni syndrome (LFS) is based on personal and/or family cancer history[1 –4] of core cancers including: breast cancer (BC), soft tissue/bone sarcoma, brain tumors, and adrenal cortical carcinoma[5]. In Classic LFS, patients have cancer at early ages (50% cancer risk by age 30) and high risk for multiple cancers over the lifespan[6]. Recently, a spectrum of LFS has been proposed incorporating broader clinical phenotypes[7]. (Source: Cancer Genetics and Cytogenetics)
Source: Cancer Genetics and Cytogenetics - April 23, 2024 Category: Genetics & Stem Cells Authors: Abigail Ward, Dana Farengo-Clark, Danielle B. McKenna, Anton Safonov, Madeline Good, Anh Le, Lisa Kessler, Payal D. Shah, Angela R. Bradbury, Susan M. Domchek, Katherine L. Nathanson, Jacquelyn Powers, Kara N. Maxwell Source Type: research
Short- and long-term post-nephrectomy outcomes for retroperitoneal liposarcoma from a high-volume sarcoma center: a propensity score matching analysis
ConclusionsRLPS resection with nephrectomy is related to a mild progression of renal impairment; however, dialysis is rare. En bloc nephrectomy for complete resection of RLPS is safe and improves local control. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - April 23, 2024 Category: Cancer & Oncology Source Type: research
A gastric sarcoma from 3000 years ago: paleopathological diagnosis at the field
ConclusionsMalignant diseases are seldom described in Paleopathology; to our knowledge, this is the oldest and most unique case of this type of pathology in mummies worldwide. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - April 22, 2024 Category: Cancer & Oncology Source Type: research
Differential metabolic secretion between mdx mouse-derived spindle cell sarcomas and rhabdomyosarcomas drives tumor type development
In this study, we aimed to use metabolomics to better understand the rarity of SCS development in mdx mice. Gas chromatography-mass spectrometry was employed to compare the metabolic profiles of spontaneously developed SCS and RMS tumors from mdx mice, and metabolite supplementation assays and silencing experiments were used to assess the effects of metabolic differences in SCS tumor-derived cells. The levels of 75 metabolites exhibited differences between RMS and SCS, 25 of which were significantly altered. Further characterization revealed downregulation of non-essential amino acids, including alanine, in SCS tumors. Ala...
Source: Am J Physiol Cell Ph... - April 22, 2024 Category: Cytology Authors: Emma Eko Tabe Niba Hiroyuki Awano Noriyuki Nishimura Hiroshi Koide Masafumi Matsuo Masakazu Shinohara Source Type: research
Differential metabolic secretion between mdx mouse-derived spindle cell sarcomas and rhabdomyosarcomas drives tumor type development
In this study, we aimed to use metabolomics to better understand the rarity of SCS development in mdx mice. Gas chromatography-mass spectrometry was employed to compare the metabolic profiles of spontaneously developed SCS and RMS tumors from mdx mice, and metabolite supplementation assays and silencing experiments were used to assess the effects of metabolic differences in SCS tumor-derived cells. The levels of 75 metabolites exhibited differences between RMS and SCS, 25 of which were significantly altered. Further characterization revealed downregulation of non-essential amino acids, including alanine, in SCS tumors. Ala...
Source: American Journal of Physiology. Cell Physiology - April 22, 2024 Category: Cytology Authors: Emma Eko Tabe Niba Hiroyuki Awano Noriyuki Nishimura Hiroshi Koide Masafumi Matsuo Masakazu Shinohara Source Type: research
Partially Ablative Body Radiotherapy (PABR): A novel approach for palliative radiotherapy of locally advanced bulky unresectable sarcomas. In regard to Yu et al
Radiother Oncol. 2024 Apr 20:110274. doi: 10.1016/j.radonc.2024.110274. Online ahead of print.NO ABSTRACTPMID:38648992 | DOI:10.1016/j.radonc.2024.110274 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 22, 2024 Category: Radiology Authors: Aysenur Elmali Erkan Topkan Cem Onal Source Type: research
Update on Percutaneous Ablation for Sarcoma
AbstractPurpose of ReviewTo provide an update on the current state of percutaneous thermal ablation in the treatment of sarcoma.Recent FindingsData continue to accrue in support of ablation for local control and palliation of specific sarcoma subtypes such as extra-abdominal desmoid fibromatosis and for broader indications such as the treatment of oligometastatic disease. The synergistic possibilities of various combination therapies such as cryoablation and immunotherapy represent intriguing areas of active investigation. Histotripsy is an emerging non-invasive, non-thermal ablative modality that may further expand the th...
Source: Current Oncology Reports - April 22, 2024 Category: Cancer & Oncology Source Type: research
Partially Ablative Body Radiotherapy (PABR): A novel approach for palliative radiotherapy of locally advanced bulky unresectable sarcomas
We thank Elmali et al. [1] for the points they raised regarding our paper. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - April 21, 2024 Category: Radiology Authors: Kelvin Ken Yu, Adam Yeo, Samuel Ngan, Julie Chu, David Chang, Shankar Siva, Aaron Wong, Tomas Kron, Nick Hardcastle, Mathieu Gaudreault, Therese Chesson, Siena Williams, Mark Burns, Sarat Chander Tags: Letter to the Editor Source Type: research
The carpal tunnel syndrome secondary to epithelioid sarcoma: A case report
Asian J Surg. 2024 Apr 20:S1015-9584(24)00731-0. doi: 10.1016/j.asjsur.2024.04.071. Online ahead of print.NO ABSTRACTPMID:38643054 | DOI:10.1016/j.asjsur.2024.04.071 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - April 20, 2024 Category: Surgery Authors: Tao Chen Desong Huang Xiang Yang Ping Yang Source Type: research
