Fight Aging! Newsletter, July 22nd 2019
This study elucidates the potential to use mitochondria from different donors (PAMM) to treat UVR stress and possibly other types of damage or metabolic malfunctions in cells, resulting in not only in-vitro but also ex-vivo applications. Gene Therapy in Mice Alters the Balance of Macrophage Phenotypes to Slow Atherosclerosis Progression https://www.fightaging.org/archives/2019/07/gene-therapy-in-mice-alters-the-balance-of-macrophage-phenotypes-to-slow-atherosclerosis-progression/ Atherosclerosis causes a sizable fraction of all deaths in our species. It is the generation of fatty deposits in blood vessel walls, distorting, narrowing, and weakening the blood vessels. This ultimately leads to the major structural failure of a stroke or heart attack, in which a vital blood vessel ruptures or is blocked. Lipids, such as cholesterols, are carried in the blood stream throughout life, associated with low-density lipoprotein (LDL) particles. The innate immune cells known as macrophages are responsible for removing cholesterol from blood vessel walls via the processes of reverse cholesterol transport: macrophages ingest the cholesterol and pass it on to high-density lipoprotein (HDL) particles, which carry it back to the liver for excretion. In youth, reverse cholesterol transport keeps blood vessels in good shape. With age, however, an increasing fraction of lipids become oxidized and damaged. This is in part a consequence of mitochondrial dysfunction and in...
Is erector spinae plane block an effective strategy to improve postsurgical analgesia?BMC Anesthesiology
What can serum calprotectin levels tell us about disease activity and severity in inflammatory rheumatic diseases?Arthritis Research &Therapy
Authors: Mjaess G, Karam A, Aoun F, Albisinni S, Roumeguère T Abstract COVID-19 is the pandemic that hit the world starting December 2019. Recent studies and international statistics have shown an increased prevalence, morbidity as well as mortality of this disease in male patients compared to female patients. The aim of this brief communication is to describe the pathophysiology of this sex-discrepancy, based on the infectivity mechanism of the coronavirus including the Angiotensin-Converting Enzyme 2 (ACE2), the Type II transmembrane Serine Protease (TMPRSS2), and the androgen receptor. This could help und...
HIGH blood pressure risk could be lowered by making some diet or exercise changes. You could lower your chances of developing deadly hypertension symptoms and signs by doing certain exercises at home. But this is the gym workout routine you should avoid, or you risk high blood pressure symptoms.
TYPE 2 diabetes affects roughly more than one in 16 people in the UK with around 3.9 million living with the dangerous condition. Finding healthy ways to help lower your blood sugar is pertinent when it comes to living with the condition and according to experts, drinking this beverage will help lower your blood sugar. What is it?
HOW TO live longer: A long and healthy life is universally appealing but it requires tenacious commitment. There is no panacea but specific dietary decisions have been shown to support you in this endeavour, including drinking an herbal tea.
BEST supplements for high blood pressure: When it comes to taking supplements there are a few which are known to be the powerhouse of supplements. For a dangerous condition such as high blood pressure, taking the best is crucial. According to leading health experts, making a daily dose of a certain supplement could help lower your blood pressure and reduce further risk. What is it?
AbstractBackgroundThe aim of the study was to determine factors predicting lymph node metastasis in patients with T1 or T2 colon cancer.MethodsA total of 906 patients with T1 or T2 colon cancer who underwent colon resection with regional lymphadenectomy in a tertiary hospital, from January 2008 to December 2013, were analyzed. The prognostic factors for LN metastasis and the risk factors for survival were analyzed.ResultsThere were 728 patients (80.4%) without lymph node metastasis (LN-negative group) and 178 patients (19.6%) with lymph node metastasis (LN-positive group). Tumor invasion depth (P
ConclusionsThe addition of ICT before NCRT seemingly shows no survival benefit on patients with LARC, and might increase the toxicity.
SummaryChemotherapy has always been the first therapeutic option for patients with advanced non-small cell lung cancer (NSCLC) with untreatable oncogenic mutations. However, chemotherapy has demonstrated limited success and is associated with severe side effects. This research aimed to investigate the antitumor efficacy and cytotoxic safety of the conjugate ZHER2:V2-pemetrexed, a novel targeted chemotherapeutic drug. In this context, human epidermal growth factor receptor 2 (HER2) + A549 lung xenografts were treated using ZHER2:V2-pemetrexed, pemetrexed or physiological saline. Therapeutic efficacy was monit...
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