Novel Combo Falters in Metastatic Triple-Negative Breast Cancer
(MedPage Today) -- The combination of olaparib (Lynparza) and ceralasertib, an ataxia telangiectasia and RAD3-related inhibitor, did not improve outcomes in previously treated metastatic triple-negative breast cancer versus the PARP inhibitor alone... (Source: MedPage Today Hematology/Oncology)
Source: MedPage Today Hematology/Oncology - May 5, 2022 Category: Hematology Source Type: news
Spinal Cord MRI Reveals Clues to Pathology in Friedreich's Ataxia Spinal Cord MRI Reveals Clues to Pathology in Friedreich's Ataxia
Imaging data sheds light on the pathology behind this genetic, neurodegenerative disorder.First Look (Source: Medscape Neurology and Neurosurgery Headlines)
Source: Medscape Neurology and Neurosurgery Headlines - April 27, 2022 Category: Neurology Tags: Neurology & Neurosurgery News Source Type: news
Novel Steroid Therapy May Counter Ataxia Telangiectasia Novel Steroid Therapy May Counter Ataxia Telangiectasia
A novel therapy for ataxia telangiectasia that delivers dexamethasone sodium phosphate through red blood cells is both ' promising and impressive ' in a new phase 3 trial, experts say.Medscape Medical News (Source: Medscape Allergy Headlines)
Source: Medscape Allergy Headlines - April 8, 2022 Category: Allergy & Immunology Tags: Neurology & Neurosurgery News Source Type: news
Reata Pharmaceuticals Completes Rolling Submission of New Drug Application for Omaveloxolone for the Treatment of Patients with Friedreich ’s Ataxia
PLANO, Texas--(BUSINESS WIRE) March 31, 2022 -- Reata Pharmaceuticals, Inc. (Nasdaq: RETA), (“Reata,” the“Company,”“our,”“us,” or“we”), a clinical-stage biopharmaceutical company,... (Source: Drugs.com - New Drug Applications)
Source: Drugs.com - New Drug Applications - March 31, 2022 Category: Drugs & Pharmacology Source Type: news
Taking too many vitamin D supplements? Ataxia may occur - what are the signs?
VITAMIN D helps regulate the amount of calcium and phosphate in the body, which are both needed to keep bones, teeth, and muscles healthy. Although it is very important, and deficiencies can cause an array of issues, those who take supplements must avoid taking too much of the so-called "sunshine vitamin". (Source: Daily Express - Health)
Source: Daily Express - Health - March 12, 2022 Category: Consumer Health News Source Type: news
Effects of therapeutic exercise on disease severity, balance, and functional independence among individuals with cerebellar ataxia: a systematic review with meta-analysis - Winser S, Chan HK, Chen WK, Hau CY, Leung SH, Leugn KY, Bello UM.
BACKGROUND: Balance impairments are common in cerebellar ataxia. Exercises are beneficial in this population. OBJECTIVE: Explore the benefits of therapeutic exercises on disease severity, balance and functional independence in cerebellar ataxia. ... (Source: SafetyLit)
Source: SafetyLit - March 1, 2022 Category: International Medicine & Public Health Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news
Fatty liver disease: Ataxia telangiectasia could be a symptom - what is it?
FATTY liver disease is on the rise and as such a multitude of health warnings and other unsettling symptoms are frequently discussed. What neurological symptoms can occur with the disease? (Source: Daily Express - Health)
Source: Daily Express - Health - February 7, 2022 Category: Consumer Health News Source Type: news
Reata Pharmaceuticals Initiates Rolling Submission of New Drug Application with U.S. FDA for Omaveloxolone for the Treatment of Patients with Friedreich ’s Ataxia
If Approved, Omaveloxolone Would Become the First Therapy Indicated for the Treatment of Patients with Friedreich’s Ataxia PLANO, Texas--(BUSINESS WIRE) January 31, 2022 -- Reata Pharmaceuticals, Inc. (Nasdaq: RETA),... (Source: Drugs.com - New Drug Applications)
Source: Drugs.com - New Drug Applications - January 31, 2022 Category: Drugs & Pharmacology Source Type: news
Identification of gait unbalance and fallers among subjects with cerebellar ataxia by a set of trunk acceleration-derived indices of gait - Castiglia SF, Trabassi D, Tatarelli A, Ranavolo A, Varrecchia T, Fiori L, Di Lenola D, Cioffi E, Raju M, Coppola G, Caliandro P, Casali C, Serrao M.
This study aimed to assess the ability of 25 gait indices to characterize gait instability and recurrent fallers among persons with primary degenerative cerebellar ataxia (pwCA), regardless of gait speed, and investigate their correlation with clinical and... (Source: SafetyLit)
Source: SafetyLit - January 29, 2022 Category: International Medicine & Public Health Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news
Anteroposterior stability: a determinant of gait dysfunction and falls in spinocerebellar ataxia - Ganapathy VS, James TT, Philip M, Kamble N, Bhattacharya A, Dhargave P, Pal PK.
BACKGROUND: Establishing an association between gait variability and direction specific balance indices may help in identifying the risk of falls in patients with spinocerebellar ataxia (SCA) which may help in developing an appropriate intervention. This s... (Source: SafetyLit)
Source: SafetyLit - November 8, 2021 Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
What is Refeeding Syndrome?
Discussion Anorexia nervosa is an eating disorder with an intense fear of being overweight (i.e. distorted body image), and self-starvation and excessive weight loss. It is more common in women (1.2%) than men (0.2%) but can be seen in both genders. Risk factors include high-intelligence, perfectionism/inflexibility, anxiety, activities where thinner body types are expected (e.g. dancer, diver, gymnast, long-distance runner, volleyball player, etc.) Other eating disorders include bulimia nervosa (i.e. cycles of binge eating and then purging), binge eating disorder (i.e. purging), orthorexia (i.e. obsessions with healthful ...
Source: PediatricEducation.org - October 25, 2021 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news
Friedreich's Ataxia Treatment Shows Extended Benefit Friedreich's Ataxia Treatment Shows Extended Benefit
A treatment that protects against inflammation may also help in slowing progression of Friedreich ' s ataxia out to more than 2 years, a new phase 2 trial suggests.Medscape Medical News (Source: Medscape Neurology and Neurosurgery Headlines)
Source: Medscape Neurology and Neurosurgery Headlines - September 21, 2021 Category: Neurology Tags: Neurology & Neurosurgery News Source Type: news
Social Security Adds Pericardial Mesothelioma to Disabilities List
The U.S. Social Security Administration has added pericardial mesothelioma to its Compassionate Allowances list, accelerating the disabilities application process for this very rare cancer. Its decision was prompted by the work of Missy Miller, medical outreach director at The Mesothelioma Center. She made the request with the Social Security disability office almost a year ago on behalf of a patient. The Compassionate Allowances program is reserved for severe medical diseases and conditions that automatically meet Social Security standards for disability benefits. It cuts short the often drawn-out application proces...
Source: Asbestos and Mesothelioma News - August 18, 2021 Category: Environmental Health Authors: Fran Mannino Source Type: news
What Problems are Ciliopathies Associated With?
Discussion Nephronophthisis (NPHP) one cause of end-stage renal disease (ESRD) usually occurring before age 30 years. NPHP is a non-motile ciliopathy affecting cellular sensing in the renal tubular epithelium. See To Learn More below. The incidence varies according to location with 1:1 million in the US but 1:50,000 in Finland. There are 3 subtypes: Infantile Occurs usually within 1 year of life Enlarged kidneys and severe hypertension In utero can have oligohydramnios problems such as pulmonary hypoplasia, facial dysmorphisms, limb contractures Extra-renal problems include congenital heart disease, liver fibrosis, recur...
Source: PediatricEducation.org - July 5, 2021 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news
Larimar Therapeutics stock plunges after FDA halts clinical trial
Larimar Therapeutics' stock plummeted by more than 33% Wednesday after the U.S. Food and Drug Administration halted the Bala Cynwyd company's clinical development of its lead new drug candidate. The FDA put a clinical hold on trials of CTI-1601, Larimar's experimental therapy for Friedreich’s ataxia, following the company's previous notification to the federal agency concerning mortalities which occurred at the highest dose levels in an ongoing 180-day non-human primate toxicology study . In… (Source: bizjournals.com Health Care:Physician Practices headlines)
Source: bizjournals.com Health Care:Physician Practices headlines - May 26, 2021 Category: American Health Authors: John George Source Type: news