Protein linked to ALS/Ataxia could play key role in other neurodegenerative disorders
(University of Utah Health) A new study suggests that some neurological disorders share a common underlying thread. Staufen1, a protein that accumulates in the brains of patients with certain neurological conditions, is linked to amyotrophic lateral sclerosis (ALS), or Lou Gehrig's disease, along with other neurological disorders, including Alzheimer's, Parkinson's, and Huntington's disease, according to University of Utah Health scientists. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 15, 2021 Category: International Medicine & Public Health Source Type: news

CUHK unveils balance between two protein counteracting forces in hereditary ataxias
(The Chinese University of Hong Kong) Spinocerebellar ataxia type 3 (SCA3), also known as Machado-Joseph Disease (MJD), describes the most common form of dominantly inherited ataxia in many populations worldwide, including Hong Kong and mainland China. SCA3 or MJD patients often present problems with gait and balance, blurred vision, and speech difficulties. The symptoms are progressive, and patients may eventually decline into a bed-ridden state. To date, SCA3 or MJD remains an incurable disorder. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - February 28, 2021 Category: Biology Source Type: news

Deep brain stimulation and exercise restore movement in ataxia
(Baylor College of Medicine) New research from Baylor College of Medicine scientists shows that a combination of deep brain stimulation (DBS) and exercise has potential benefits for treating ataxia, a rare genetic neurodegenerative disease characterized by progressive irreversible problems with movement. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 26, 2021 Category: International Medicine & Public Health Source Type: news

C-Path and Global Partners launch Ataxia Consortium
(Critical Path Institute (C-Path)) Critical Path Institute today announced the launch of the Critical Path to Therapeutics for the Ataxias Consortium, a public-private partnership focused on optimizing clinical trials for inherited ataxias. CPTA is a collaborative effort between C-Path, Ataxia Global Initiative, the National Ataxia Foundation, Ataxia UK and key partners in the industry and academic research communities, including Biohaven Pharmaceuticals, Ionis Pharmaceuticals, Roche Pharmaceuticals, Servier Group, Triplet Therapeutics, uniQure, and Vico Therapeutics. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 26, 2021 Category: International Medicine & Public Health Source Type: news

Establish a nomogram to predict falls in spinocerebellar ataxia type 3 - Lin J, Zhang L, Cao B, Wei Q, Ou R, Hou Y, Xu X, Liu K, Gu X, Shang H.
PURPOSE: Falls are common and are frequently accompanied by injuries in patients with spinocerebellar ataxias type 3 (SCA3). We explored which factors could predict falls in a cohort of patients with SCA3 and developed a nomogram model to predict the first... (Source: SafetyLit)
Source: SafetyLit - February 17, 2021 Category: International Medicine & Public Health Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news

Repeated occupational exposure to low-level blast in the Canadian armed forces: effects on hearing, balance, and ataxia - Nakashima A, Vartanian O, Rhind SG, King K, Tenn C, Jetly CR.
INTRODUCTION: Recently, there has been increasing concern about the adverse health effects of long-term occupational exposure to low-level blast in military personnel. Occupational blast exposure occurs routinely in garrison through use of armaments and co... (Source: SafetyLit)
Source: SafetyLit - January 27, 2021 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news

"Chasing the dragon": a fatal case report of toxic leucoenc éphalopathie due to inhaled heroin - Ochoa-Orozco SA, Gutiérrez-Segura JC, Coral-Leiton AM, Trejos-Orozco EA, Gutiérrez-Sanjuán I, Carvajal-Guevara JD.
BACKGROUND: Leukoencephalopathy is a myelin disorder caused by multiple agents, including substance abuse. CASE: A 28-year-old man arrived at the emergency department having suffered from asthenia, dizziness, disorientation and ataxia for two months. H... (Source: SafetyLit)
Source: SafetyLit - December 21, 2020 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

COVID-19 may also invade the central nervous system, cause neurological illnesses
(Cleveland Clinic) COVID-19 is known primarily as a respiratory disease, with symptoms that include cough, shortness of breath, and, in severe cases, acute respiratory distress syndrome and pneumonia. Now, Cleveland Clinic researchers note in a recent review that infection with the coronavirus may also affect the central nervous system and cause corresponding neurological disorders, including ischemic stroke, encephalitis, encephalopathy and epileptic seizures.According to the review published in Cells, the symptoms of COVID-19-related neurological manifestations include dizziness, headache, a loss of consciousness and ata...
Source: EurekAlert! - Infectious and Emerging Diseases - December 10, 2020 Category: Infectious Diseases Source Type: news

PTC Therapeutics Announces Initiation of Global Phase 3 Clinical Trial to Evaluate Vatiquinone in Friedreich Ataxia
Third trial initiated in 2020 from compounds identified from PTC's Bio-e platform SOUTH PLAINFIELD, N.J., Nov. 30, 2020 -- (Healthcare Sales & Marketing Network) -- PTC Therapeutics, Inc. (NASDAQ: PTCT), today announced the initiation of the registrati... Biopharmaceuticals PTC Therapeutics, vatiquinone, Friedreich ataxia (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - November 30, 2020 Category: Pharmaceuticals Source Type: news

Dizzy spells could be a warning sign that your brain is being damaged by eating BREAD
The condition, called gluten ataxia, occurs when, for reasons not fully understood, the immune system goes haywire in response to gluten in the food and attacks parts of the brain. (Source: the Mail online | Health)
Source: the Mail online | Health - November 28, 2020 Category: Consumer Health News Source Type: news

UB study identifies new functions in the Machado-Joseph genetic disease
(University of Barcelona) Ataxia is a minority disease with genetic origins, known for its neuromuscular alterations due to the selective loss of neurons in the cerebellum. University of Barcelona researchers have identified new functions in the ataxin 3 gene (ATXN3) -which causes Machado-Joseph disease, the most common type of ataxia- in the development of retina photoreceptors. These results are relevant also to understand other diseases, such as macular degenerations. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - November 25, 2020 Category: Biology Source Type: news

Neuropsychological, neurocognitive, vestibular, and neuroimaging correlates of exposure to repetitive low-level blast waves: evidence from four nonoverlapping samples of Canadian breachers - Vartanian O, Coady L, Blackler K, Fraser B, Cheung B.
INTRODUCTION: We assessed the utility of a battery of neuropsychological, neurocognitive, physiological (balance, ataxia, postural tremor), and neuroimaging measures for studying the effects of blast waves in breachers-a population repeatedly exposed to lo... (Source: SafetyLit)
Source: SafetyLit - November 5, 2020 Category: International Medicine & Public Health Tags: Burns, Electricity, Explosions, Fire, Scalds Source Type: news

The effects of dual task cognitive interference and fast-paced walking on gait, turns, and falls in men and women with FXTAS - O'Keefe JA, Guan J, Robertson E, Biskis A, Joyce J, Ouyang B, Liu Y, Carnes D, Purcell N, Berry-Kravis E, Hall DA.
We examined the impact of dual-task (DT) cognitive-motor interference and fast-paced (FP) gai... (Source: SafetyLit)
Source: SafetyLit - November 2, 2020 Category: International Medicine & Public Health Tags: Distraction, Fatigue, Chronobiology, Vigilance, Workload Source Type: news

Mayo Clinic: diagnostic, therapeutic advance for rare neurodegenerative disorder
(Mayo Clinic) Mayo Clinic researchers, along with national and global collaborators, have developed a potential test for Machado-Joseph disease, or spinocerebellar ataxia type 3 (SCA3) ? a disease that has no cure. They also have clarified the role of a gene target associated with the disease. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - October 21, 2020 Category: International Medicine & Public Health Source Type: news

Toxin-induced cerebellar disorders - Dolbec K, Dobbs MR, Ibraheem M.
The cerebellum plays an important role in motor and nonmotor systems, with damage resulting in clinical manifestations presenting as weakness, ataxia, dysarthria, and nystagmus. There are numerous environmental and industrial agents as well as medications ... (Source: SafetyLit)
Source: SafetyLit - October 14, 2020 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

BioShin, Biohaven's Asia-Pacific Subsidiary, Raises $60M in Series A Funding to Advance Neuroscience Pipeline in Asia-Pacific Region
Initiating NURTEC ODT Phase 3 study for acute migraine in China and Korea, and China registrational study of troriluzole in Spinocerebellar Ataxia in 4Q20 Named Donnie McGrath as BioShin President and Executive Chairman, and Karl Lintel as BioShin Chief... Biopharmaceuticals, Personnel, Venture Capital Biohaven Pharmaceutical Holding Company, BioShin , NURTEC ODT (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - September 28, 2020 Category: Pharmaceuticals Source Type: news

Unintentional overdose of hyoscine hydrobromide in a young child - Xuereb G, Calleja T, Borg J, Pace D.
A 4-year-old girl presented with confusion, ataxia and hallucinations 3 hours after an accidental overdose of 108 μg per kg of hyoscine hydrobromide (Kwells Kids). She was hypotensive and tachycardic at presentation. Investigations revealed QTc prolongati... (Source: SafetyLit)
Source: SafetyLit - September 18, 2020 Category: International Medicine & Public Health Tags: Age: Infants and Children Source Type: news

Gene therapy corrects the cardiac effects of Friedreich's ataxia
(Mary Ann Liebert, Inc./Genetic Engineering News) Gene therapy was successfully used to overcome the cardiac effects of Freidreich's ataxia (FA) in a mouse model of the disease (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - September 18, 2020 Category: International Medicine & Public Health Source Type: news

Artificial intelligence and fractal dimension for monitoring ataxia
(Universit à di Bologna) A new Unibo-led project won the Spring Seed Grant by Telethon Foundation. Researchers will work to develop innovative techniques and cutting-edge computational approaches to fight rare and extremely debilitating diseases such as Friedreich's and spinocerebellar ataxia. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - September 18, 2020 Category: International Medicine & Public Health Source Type: news

New molecule to repair and restore brain and spinal cord function
A molecule created by researchers can restore lost connections in the spinal cord and brain of mice with neurological disorders including cerebellar ataxia, Alzheimer’s disease and spinal cord injury. (Source: Medical Research Council General News)
Source: Medical Research Council General News - August 27, 2020 Category: Research Source Type: news

A synthetic synaptic organizer protein restores glutamatergic neuronal circuits
Neuronal synapses undergo structural and functional changes throughout life, which are essential for nervous system physiology. However, these changes may also perturb the excitatory–inhibitory neurotransmission balance and trigger neuropsychiatric and neurological disorders. Molecular tools to restore this balance are highly desirable. Here, we designed and characterized CPTX, a synthetic synaptic organizer combining structural elements from cerebellin-1 and neuronal pentraxin-1. CPTX can interact with presynaptic neurexins and postsynaptic AMPA-type ionotropic glutamate receptors and induced the formation of excita...
Source: ScienceNOW - August 26, 2020 Category: Science Authors: Suzuki, K., Elegheert, J., Song, I., Sasakura, H., Senkov, O., Matsuda, K., Kakegawa, W., Clayton, A. J., Chang, V. T., Ferrer-Ferrer, M., Miura, E., Kaushik, R., Ikeno, M., Morioka, Y., Takeuchi, Y., Shimada, T., Otsuka, S., Stoyanov, S., Watanabe, M., T Tags: Biochemistry, Neuroscience, Online Only r-articles Source Type: news

Biotech Vico Therapeutics raises $31 million (€27 million) in Series A financing round to advance therapies for rare central nervous system diseases
AON-platform with focus on therapies nearing phase I trials for forms of Spinocerebellar Ataxia and Huntington Disease Other early discovery stage RNA editing platform focuses on RETT syndrome Funding led by LSP, co-led by Kurma Partners, supported b... Biopharmaceuticals, Neurology, Venture Capital Vico Therapeutics, RNA modulating therapies (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - July 29, 2020 Category: Pharmaceuticals Source Type: news

Exercise offers 'profound' benefits for Friedreich's ataxia, research suggests
(University of Virginia Health System) Well-timed exercise programs may slow the progression of Friedreich's ataxia, which robs patients of their ability to walk, new research suggests. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - June 16, 2020 Category: International Medicine & Public Health Source Type: news

A natural amino acid could be a novel treatment for polyglutamine diseases
(Osaka University) Researchers from Osaka University, National Center of Neurology and Psychiatry, and Niigata University identified the amino acid arginine as a potential disease-modifying drug for polyglutamine diseases, including familial spinocerebellar ataxia and Huntington disease. Using various mice models of polyglutamine diseases, they showed that arginine prevents polyglutamine protein aggregation, improves motor function and suppresses neurodegeneration of mice. The results of this study could facilitate the clinical use of arginine for polyglutamine diseases that are, to date, incurable. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - May 25, 2020 Category: Biology Source Type: news

Genetic doppelgaengers: Emory research provides insight into two neurological puzzles
(Emory Health Sciences) Insight into the pathological mechanisms behind two devastating neurodegenerative diseases: the most common inherited form of amyotrophic lateral sclerosis/ frontotemporal dementia (ALS/FTD) and spinocerebellar ataxia type 36 (SCA36). Expanded repeats lead to peptide gobbledygook in both, but with critical differences. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 5, 2020 Category: International Medicine & Public Health Source Type: news

Pediatric perampanel poisoning - Qozi M, Cantrell FL.
Highlights • 0.77 mg/kg perampanel caused drowsiness, ataxia and bradycardia in a child. • 0.25 mg/kg perampanel caused quick onset ataxia in a child that resolved in 6 h. • Pediatric perampanel exposures can resemble benzodiazapine exposure... (Source: SafetyLit)
Source: SafetyLit - May 4, 2020 Category: International Medicine & Public Health Tags: Age: Infants and Children Source Type: news

Some COVID Patients Develop Guillain-Barre
The symptoms of the disorder "include weakness, areflexia [absence of reflexes], paresthesia [tingling], and in some cases facial weakness and ataxia [poor balance]," Geraci said. (Source: WebMD Health)
Source: WebMD Health - April 21, 2020 Category: Consumer Health News Source Type: news

Progressive ataxia and falls in a 62 year old woman - Jedidi Z, Bianchi E, Moonen V, Jedidi H, Serre CH, Maquet P, Moonen G.
We discuss the diagnostic workup of a 62 year old woman without any significant past medical history. We take this opportunity to point out three aspects : 1. The necessary contextualization of the whole process allowing to avoid unrealistic differentials;... (Source: SafetyLit)
Source: SafetyLit - March 16, 2020 Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news

Friedreich's Ataxia Syndrome
Title: Friedreich's Ataxia SyndromeCategory: Diseases and ConditionsCreated: 2/25/2020 12:00:00 AMLast Editorial Review: 2/25/2020 12:00:00 AM (Source: MedicineNet Kids Health General)
Source: MedicineNet Kids Health General - February 25, 2020 Category: Pediatrics Source Type: news

Visual impairment following a suicide attempt with a crossbow - Feenstra FA, Aggenbach L, Rijtema G, Buunk AM, Stirler VMA.
BACKGROUND: B álint's syndrome is characterized by the triad of ocular apraxia, dorsal simultanagnosia and optic ataxia. It most commonly occurs following bilateral parieto-occipital brain injury, for which several aetiologies have been described. CASE DES... (Source: SafetyLit)
Source: SafetyLit - February 24, 2020 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news

Exploring risk of falls and dynamic unbalance in cerebellar ataxia by inertial sensor assessment - Caliandro P, Conte C, Iacovelli C, Tatarelli A, Castiglia SF, Reale G, Serrao M.
BACKGROUND: Patients suffering from cerebellar ataxia have extremely variable gait kinematic features. We investigated whether and how wearable inertial sensors can describe the gait kinematic features among ataxic patients. METHODS: We enrolled 17... (Source: SafetyLit)
Source: SafetyLit - December 23, 2019 Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news

Suicide screening: how to recognize and treat at-risk adults - Williamson MLC, Hogue G, Cotter J, Roberman S, Neal G, Williamson B.
Worsening nausea, vomiting, and dizziness for 2-months, resulting in a 20-pound weight loss. Pruritus. Ataxia. Mild hearing loss, with reoccurring episodes of falls. Language: en... (Source: SafetyLit)
Source: SafetyLit - November 19, 2019 Category: International Medicine & Public Health Tags: Risk Factor Prevalence, Injury Occurrence Source Type: news

Medical News Today: Acute cerebellar ataxia: Everything you need to know
Acute cerebellar ataxia is a disorder in children that causes a loss of coordination and movement control. Learn about the causes and treatments in this article. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - October 31, 2019 Category: Consumer Health News Tags: Pediatrics / Children's Health Source Type: news

Tissue-Engineered Human Models of Cardiac Disease: A Case Study of...
Friedreich’s ataxia (FRDA) is an autosomal recessive disease that affects mainly the peripheral and central nervous systems, and heart. Currently, there are few effective treatments to manage...(PRWeb October 17, 2019)Read the full story at https://www.prweb.com/releases/tissue_engineered_human_models_of_cardiac_disease_a_case_study_of_friedreichs_ataxia_frda_upcoming_webinar_hosted_by_xtalks/prweb16653222.htm (Source: PRWeb: Medical Pharmaceuticals)
Source: PRWeb: Medical Pharmaceuticals - October 17, 2019 Category: Pharmaceuticals Source Type: news

Scientists Designed a Drug for Just One Patient. Her Name Is Mila.
An achievement in ultra-personalized medicine also raises questions about fairness and regulation. (Source: NYT Health)
Source: NYT Health - October 10, 2019 Category: Consumer Health News Authors: Gina Kolata Tags: Drugs (Pharmaceuticals) Genetics and Heredity Disabilities Ataxia-Telangiectasia (Genetic Disease) Medicine and Health Children and Childhood Boston Children ' s Hospital Food and Drug Administration New England Journal of Medicine B Source Type: news

TP53, ATM Comutation Might Help Guide Lung-Cancer Immunotherapy TP53, ATM Comutation Might Help Guide Lung-Cancer Immunotherapy
In patients with non-small-cell lung cancer (NSCLC), the presence of tumor protein p53 (TP53) and ataxia-telangiectasia mutated (ATM) comutation might indicate better response to immune-checkpoint inhibitors (ICIs), according to Chinese researchers.Reuters Health Information (Source: Medscape Allergy Headlines)
Source: Medscape Allergy Headlines - October 3, 2019 Category: Allergy & Immunology Tags: Hematology-Oncology News Source Type: news

Health-related quality of life and depressive symptoms in Friedreich ataxia - P érez-Flores J, Hernández-Torres A, Montón F, Nieto A.
PURPOSE: Friedreich ataxia (FRDA) is a chronic, progressive and highly disabling cerebellar degenerative disease. Despite this, little attention has been paid to the health-related quality of life (HRQOL) in this disease. The aim of the present study was t... (Source: SafetyLit)
Source: SafetyLit - October 1, 2019 Category: International Medicine & Public Health Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news

REGENXBIO Announces New License Agreement with Pfizer for the Treatment of Friedreich's Ataxia Using NAV(R) AAV9 Vector
ROCKVILLE, Md., July 31, 2019 -- (Healthcare Sales & Marketing Network) -- REGENXBIO Inc. (Nasdaq: RGNX), a leading clinical-stage biotechnology company seeking to improve lives through the curative potential of gene therapy based on its proprietary NAV T... Biopharmaceuticals, Neurology, Licensing REGENXBIO, Pfizer, Friedreich's ataxia, movement disorder (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - July 31, 2019 Category: Pharmaceuticals Source Type: news

Canine companion helps man with rare genetic disorder that leaves him confined to a wheelchair
Matthew Lafleur, 33, from Opelousas, Louisiana, was diagnosed with Friedreich's Ataxia when he was 11 years old. He now gets around with the help of his new service dog named Zeego. (Source: the Mail online | Health)
Source: the Mail online | Health - July 4, 2019 Category: Consumer Health News Source Type: news

Exclusive: Bala Cynwyd company raises $25.8M
The six-year-old biopharm company's new drug candidate targets Friedreich ’s Ataxia, a progressive disease that affects multiple body systems. (Source: bizjournals.com Health Care:Physician Practices headlines)
Source: bizjournals.com Health Care:Physician Practices headlines - May 20, 2019 Category: American Health Authors: John George Source Type: news

Woman who thought she was clumsy is diagnosed with degenerative condition and now needs a walker
Madelyn Frederick, 20, from Dallas, Texas, was diagnosed in March 2013 with Friedreich's Ataxia, a rare genetic disease that affects the nervous system and causes a progressive loss of movement. (Source: the Mail online | Health)
Source: the Mail online | Health - May 15, 2019 Category: Consumer Health News Source Type: news

Woman who called herself 'clumsy' discovers she has a genetic disorder that makes her trip
Kelly Barendt, 26, from Strongsville, Ohio, was diagnosed at age 18 which had Friedreich's Ataxia, a rare genetic disease that affects the nervous system and causes a progressive loss of movement. (Source: the Mail online | Health)
Source: the Mail online | Health - April 30, 2019 Category: Consumer Health News Source Type: news

Does integrated cognitive and balance (dual-task) training improve balance and reduce falls risk in individuals with cerebellar ataxia? - Winser S, Pang MYC, Rauszen JS, Chan AYY, Chen CH, Whitney SL.
Frequent falls in people with cerebellar ataxia (CA) is a significant problem Therefore, an intervention that could improve balance and reduce the number of falls is of paramount importance from the patients' perspective. Combining cognitive training with ... (Source: SafetyLit)
Source: SafetyLit - April 25, 2019 Category: International Medicine & Public Health Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news

The responsiveness of triaxial accelerometer measurement of gait ataxia is higher than that of the scale for the assessment and rating of ataxia in the early stages of spinocerebellar degeneration - Shirai S, Yabe I, Takahashi-Iwata I, Matsushima M, Ito YM, Takakusaki K, Sasaki H.
We reported previously that the average medial-lateral gait amplitude while walking on a straight path determined using triaxial accelerometers fixed on the middle of the upper back may be a quantitative and concise indicator for the severity of cerebellar... (Source: SafetyLit)
Source: SafetyLit - April 19, 2019 Category: International Medicine & Public Health Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news

How Common Is Unintentional Cannabis Ingestion?
Discussion “[Cannabis] is a genus of flowering plant with three main varieties: sativa, indica and ruderalis.” It has been used for hundreds of years for hemp or fiber and also for psychoactive and medicinal effects. The active compounds are collectively called cannabinoids, of which delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) are the most abundant. The floral buds or calyxes of the plant have the most cannabinoids, but other parts of the plant are also used such as leaves. Hash oil, hashish (or resin) and marijuana (dried leaves) are the common products from strongest to least strongest products. ...
Source: PediatricEducation.org - March 11, 2019 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

C-Path, FARA launch Friedreich's Ataxia Clinical Database for Development of Treatments
(Critical Path Institute (C-Path)) C-Path's Data Collaboration Center and FARA announced the launch of the Friedreich's Ataxia Integrated Clinical Database. The platform will enable collaborative research and data sharing to support the understanding of natural history, biomarkers and clinical endpoints, and promote research into clinical trial design in Friedreich's ataxia. The organizations hope to enable the development of tools that will help design and interpret efficient clinical trials -- leading to effective treatments for FA as soon as possible. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 27, 2019 Category: International Medicine & Public Health Source Type: news

Delayed presentation of neck arteries dissection, caused by water slide activity - Alboudi AM, Sarathchandran P, Geblawi SS.
A 16-year-old Korean boy presented with acute onset vertigo, dysphagia and gait ataxia of 16  hours duration. He had history of headache and neck pain along with transient vertigo during a water slide ride 12 days before presentation. CT brain showed left... (Source: SafetyLit)
Source: SafetyLit - December 25, 2018 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news

Patient survival after acute voluntary poisoning with a huge dose of oxcarbazepine and olanzapine - Kalogera V, Galopoulos D, Eleftheriotis G, Meimeti E, Malios I, Marathonitis G, Loupa C.
INTRODUCTION: Oxcarbazepine is a carbamazepine pre-drug with less drug interactions. Its adverse effects, including hyponatremia, somnolence and ataxia, are dose dependent. Olanzapine is an atypical antipsychotic drug most commonly used to manage psychoses... (Source: SafetyLit)
Source: SafetyLit - December 8, 2018 Category: International Medicine & Public Health Tags: Poisoning Source Type: news

What is the Recurrence Rate for Guillian-Barr é Syndrome and Should She Get An Influenza Vaccine?
Discussion Guillian-Barré syndrome (GBS) is an acquired, acute, inflammatory, demyelinating polyneuropathy. It is the most common cause of acute and subacute flaccid paralysis in children. GBS causes about 0.4-1.3 cases per 100,000 persons/year in children. It can occur in any age group and the incidence increases among all age groups until a peak in the 50s. Both genders are affected and there may be a slight increase in males. GBS usually occurs 2-4 weeks after a prodromal gastroenteritis or respiratory illness. GBS causes autoantibody production against Schwann cells of the neuron and the axon itself. There is ...
Source: PediatricEducation.org - November 19, 2018 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

New study offers hope for patients suffering from a rare form of blindness
(Duke Department of Neurology) A new form of therapy may halt or even reverse a form of progressive vision loss that, until now, has inevitably led to blindness. This hyper-targeted approach offers hope to individuals living with spinocerebellar ataxia type 7 (SCA7) and validates a new form of therapy with the potential to treat neurogenetic diseases effectively and with far fewer side effects than other medications. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 1, 2018 Category: International Medicine & Public Health Source Type: news