Case series: pediatric coral snake bites
Eastern coral snake (Micrurus fulvisu)
3 out of 5 stars
Coral Snake Bites and Envenomation in Children: A Case Series. Sasaki J et al. Pediatr Emer Care 2014 Apr;30:262-265.
Abstract
Of the approximately 4700 native venomous snake bites reported to U.S. poison centers each year, about 98% involve pit vipers (Crotalinae). The other 2% result from encounters with coral snakes (Elapidae).
In contrast to bites from pit vipers, those from coral snakes typically cause minimal local tissue effects. However, coral snake envenomation can produce neurotoxicity — with delayed onset of up to 12 hours — and progress (rarely) to re...
Source: The Poison Review - May 9, 2014 Category: Toxicology Authors: Leon Tags: Medical coral snake bite eastern coral snake elapidae envenomation neurotoxicity Source Type: news
First case report of toxicity from ingestion of e-cigarette nicotine liquid
3 out of 5 stars
Nicotine Poisoning in an Infant. Bassett RA et al. N Engl J Med 2014 May 7 [Epub before print]
Full Text
This short “letter to the editor” is, to my knowledge, the first reported case of toxicity from ingestion of e-cigarette nicotine liquid. A 10-month-old male ingested an unknown amount of nicotine-containing liquid compounded at a local “vape” shop. The liquid was labelled as containing 1.8% nicotine (18 mg/ml) as well as glycerin, propylene glycol, and oil of wintergreen (methyl salicylate). the child presented with vomiting, tachycardia, “grunting” respirations, an...
Source: The Poison Review - May 8, 2014 Category: Toxicology Authors: Leon Tags: Medical case report cholinergic toxicity e-cigarette nicotine toxicity Source Type: news
Nicotinamide shows mixed results in patients with Friedreich ataxia
Read the full story on MD Consult:
Nicotinamide shows mixed results in patients with Friedreich ataxia (Source: MD Consult: News: Top Stories)
Source: MD Consult: News: Top Stories - May 3, 2014 Category: Journals (General) Source Type: news
'We Believe' National Social Media Campaign Sheds Light on...
'We Believe' is a viral social media campaign that sheds light on Friedreich's Ataxia, a rare genetic disease for which there is currently no treatment or cure. May 17th is FA Awareness...(PRWeb May 01, 2014)Read the full story at http://www.prweb.com/releases/2014/05/prweb11816434.htm (Source: PRWeb: Medical Pharmaceuticals)
Source: PRWeb: Medical Pharmaceuticals - May 2, 2014 Category: Pharmaceuticals Source Type: news
Progressive neurodegenerative disorder linked to R-loop formation
A new feature of the genetic mutation responsible for the progressive neurodegenerative disorder, fragile X-associated tremor/ataxia syndrome -- the formation of 'R-loops,' has been discovered. Researchers believe it may be associated with the disorder's neurological symptoms, such as tremors, lack of balance, features of Parkinsonism, and cognitive decline. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - April 17, 2014 Category: Science Source Type: news
Experts disagree on horses with incoordination
At least one in 100 horses at some point in its life will lose the ability to control its gait as a result of developing the neurological disorder ataxia. Once found to be ataxic, the horse is often put down, or undergoes an expensive operation with dubious results. But now researchers have shown that there is marked disagreement among veterinary surgeons about whether or not a horse is ataxic. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - April 10, 2014 Category: Science Source Type: news
Experts disagree on horses with incoordination
(University of Copenhagen) At least one in 100 horses at some point in its life will lose the ability to control its gait as a result of developing the neurological disorder ataxia. Once found to be ataxic, the horse is often put down, or undergoes an expensive operation with dubious results. But now researchers from the University of Copenhagen and the Royal Veterinary College in the UK have shown that there is marked disagreement among veterinary surgeons about whether or not a horse is ataxic. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - April 10, 2014 Category: Biology Source Type: news
Friedreich's ataxia -- an effective gene therapy in an animal model
(INSERM (Institut national de la santé et de la recherche médicale)) The team led by Hélène Puccio, director of research for Inserm at the Institute of Genetics and Molecular and Cellular Biology in close collaboration with Patrick Aubourg's team has demonstrated, in the mice, the efficacy of gene therapy for treating the heart disease associated with Friedreich's ataxia, a rare hereditary neuro-degenerative disorder. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - April 6, 2014 Category: Biology Source Type: news
What Causes Ataxia?
Discussion
Coordination and balance problems are caused by various problems affecting the central and peripheral nervous system. Normal development of a child or weakness of a child are commonly mistaken for true ataxia. Ataxia specifically refers to “…impairment of the coordination of movement without loss of muscle strength.” If it is purely due to abnormalities of the cerebellum then there should be no changes in mental status, sensation or weakness. Sometimes it is difficult to determine if there are abnormalities in other areas. For example, Guillian-Barre often presents with difficulty or clumsy wal...
Source: PediatricEducation.org - March 31, 2014 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news
Unravelling nerve-cell death in rare children's disease
(Sanford-Burnham Medical Research Institute) Researchers discover mutations in a protein that plays a role in the body's DNA repair system -- similar to what's observed in the rare children's disease ataxia-telangiectasia. The discovery provides an approach to identifying therapies that will resuscitate the broken DNA repair mechanism. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 25, 2014 Category: Global & Universal Source Type: news
FDA Grants Fast Track Designation To Edison Pharma's EPI-743
The U.S. Food and Drug Administration (FDA) has granted Fast Tack designation to Edison Pharmaceuticals’ lead drug EPI-743 for the treatment of Friedreich’s ataxia. (Source: Pharmaceutical Online News)
Source: Pharmaceutical Online News - March 19, 2014 Category: Pharmaceuticals Source Type: news
FDA Awards Fast Track Status to Edison Pharmaceuticals' EPI-743 for Friedreich's Ataxia
EPI-743 in two phase 2 development studies for Friedreich's ataxia
MOUNTAIN VIEW, Calif., March 17, 2014 -- (Healthcare Sales & Marketing Network) -- Edison Pharmaceuticals today announced that the United States Food and Drug Administration granted Fas... BiopharmaceuticalsEdison Pharmaceuticals, EPI-743, Friedreich's ataxia, Vincerinone (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - March 17, 2014 Category: Pharmaceuticals Source Type: news
FDA Grants Orphan Drug Status To Edison Pharmaceutical's EPI-743
Friedreich's Ataxia Research Alliance (FARA) has announced in a press release that the FDA has granted orphan drug status to Edison Pharmaceutical’s EPI-743 (vatiquinone). The drug treats Friedreich’s ataxia, a rare nervous system disorder. (Source: Pharmaceutical Online News)
Source: Pharmaceutical Online News - February 11, 2014 Category: Pharmaceuticals Source Type: news
Protein found to be associated with canine hereditary ataxia
Researchers have found a link between a mutation in a gene called RAB 24 and an inherited neurodegenerative disease in Old English sheepdogs and Gordon setters. The findings may help further understanding of neurodegenerative diseases and identify new treatments for both canine and human sufferers. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - February 7, 2014 Category: Science Source Type: news
Fruit flies reveal normal function of gene mutated in spinocerebellar ataxia type 7
Disruptive clumps of mutated protein are often blamed for clogging cells and interfering with brain function in patients with the neurodegenerative diseases known as spinocerebellar ataxias. But a new study in fruit flies suggests that for at least one of these diseases, the defective proteins may not need to form clumps to do harm. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - February 1, 2014 Category: Science Source Type: news
