Fight Aging! Newsletter, January 8th 2024
This study examined whether the local injection of the supernatant of activated PRP (saPRP) into the salivary gland (SG) could help prevent aging-induced SG dysfunction and explored the mechanisms responsible for the protective effects on the SG hypofunction.
Human salivary gland epithelial cells (hSGEC) were treated with saPRP or PRP after senescence through irradiation. The significant proliferation of hSGEC was observed in saPRP treated group compared to irradiation only group and irradiation + PRP group. Cellular senescence, apoptosis, and inflammation were significantly reduced in the saPRP group.
Th...
Source: Fight Aging! - January 7, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Failing Mitochondrial Quality Control in Aging and Neurodegeneration
Every one of our cells contains hundreds of mitochondria, the descendants of ancient symbiotic bacteria now fully integrated into our biochemistry. Mitochondria contain their own small remnant genome, the mitochondrial DNA, replicate like bacteria, and toil to produce adenosine triphosphate (ATP), a chemical energy store molecule used to power cell processes. Mitochondrial function declines with age, unfortunately, and our cells suffer for it. This contributes meaningfully to many age-related conditions. This decline appears to result in large part from changes in gene expression that impair the various quality control pro...
Source: Fight Aging! - January 2, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, August 21st 2023
This study aimed to investigate the association between frailty index and circulating CAP2 concentration in 467 community-dwelling older adults (median age: 79; range: 65-92 years). The selected robust regression model showed that circulating CAP2 concentration was not associated with chronological age, as well as sex and education. However, circulating CAP2 concentration was significantly and inversely associated with the frailty index: a 0.1-unit increase in frailty index leads to ~0.5-point mean decrease in CAP2 concentration. Furthermore, mean CAP2 concentration was significantly lower in frail participants (i.e., fr...
Source: Fight Aging! - August 21, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Treating a Mouse Model of Alzheimer's Disease with Hematopoietic Stem Cell Transplantation
Overly reactive, senescent, and otherwise inflammatory microglia in the brain are implicated in the development of neurodegenerative conditions. Chronic inflammation in brain tissue disrupts neural function in numerous ways. Thus why not clear or replace microglia? There are established ways to remove these cells, allowing them to regenerative over a few weeks, but these have not yet made their way to human trials for neurodegenerative conditions, despite interesting results in animal models. The replacement of microglia via transplantation of hematopoietic cells is at a similar stage, wherein there are interesting results...
Source: Fight Aging! - August 17, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
What Is GHB Anyway?
Let’s face it, there are a whole bunch of street drugs out there that we as EMS caregivers should understand. While we can’t always be expected to identify the exact drug a patient has ingested. We do need to be able to predict a given drugs effect on the body.
We should also be able to take a fair guess at the identity of an ingested drug based on our evaluation of the patient’s physical presentation. GHB is one of those drugs that can be hard to nail down based on the physical signs. But it does leave some clues – if you know what your look for.
What Is It? : A Multi-Receptor Stimulant
GHB is short for ...
Source: The EMT Spot - November 10, 2022 Category: Emergency Medicine Authors: Steve Whitehead Tags: EMT Source Type: blogs
To Walk or Not To Walk?
The Happy Medic (THM) recently posted a fantastic topic on his blog. I love diving into controversial decisions that we have to make every shift. Here’s one of those questions that we need to answer on just about every call. Should we walk the patient to the pram or carry them?
This is one of those things that we have no choice but to address in every system on just about every call. How to we get the patient to the pram? When is it OK to walk them?
It seems like this subject got rolling on Justin’s (THM) blog when EMS types from around the country started sending him feedback about his role in the documenta...
Source: The EMT Spot - November 9, 2022 Category: Emergency Medicine Authors: Steve Whitehead Tags: EMT Source Type: blogs
Fight Aging! Newsletter, October 17th 2022
This study investigated whether multimorbidity is associated with incident dementia and whether associations vary by different clusters of disease and genetic risk for dementia. The study used data from the UK Biobank cohort, with baseline data collected between 2006 and 2010 and with up to 15 years of follow-up. Participants included women and men without dementia and aged at least 60 years at baseline. The presence of at least 2 long-term conditions from a preselected list of 42 conditions was used to define multimorbidity.
A total of 206,960 participants (mean age 64.1 years) were included in the final sample, of...
Source: Fight Aging! - October 16, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Cancers Force T Cells into Senescence
We report that both mouse malignant tumor cells and regulatory T cells (Tregs) can induce responder T cell senescence, similar as shown in human Treg and tumor cells. Accumulated senescent T cells also exist in the TME in tumor models of lung cancer, breast cancer, and melanoma. Induction of ataxia-telangiectasia mutated protein (ATM)-associated DNA damage is the cause for T cell senescence induced by both mouse tumor cells and Treg cells, which is also regulated by mitogen-activated protein kinase (MAPK) signaling.
Furthermore, blockages of ATM-associated DNA damage and/or MAPK signaling pathways in T cells can pre...
Source: Fight Aging! - October 13, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
GATA4 and Cellular Senescence
Researchers have in the past connected GATA4 expression to various age-related conditions, such as scarring in heart tissue. Here, they link GATA4 to cellular senescence, which is also implicated in many of the same conditions. Senescent cells accumulate with age, and their pro-growth, pro-inflammatory signals are disruptive to tissue function throughout the body. In recent years the evidence for clearance of senescent cells via senolytic therapies to be beneficial in older individuals has prompted greater research to connect cellular senescence to many other lines of research in the context of aging and age-related diseas...
Source: Fight Aging! - October 10, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Pearls Chiari malformation
1.80 percent of patients with cough headache have cm type 1 although only a minority of patients with cm 1 have cough headache. The degree of tonsillar herniation does not correlatevar pageTracker = _gat._getTracker( " UA-3639768-12 " ); pageTracker._initData(); pageTracker._trackPageview();2. Cm1 presents most often from ages 8 to 9 and from 31 to 463. Spinal cord syndrome occurs in 65 to 84 percent and includes weakness and sensory changes.4. Brain stem syndrome occurs in 22 to 38 percent and includes blurred vision, horizontal or downbeating nystagmus, and diplopia (upper) or hoarseness , dysphonia, dysarthria...
Source: neurologyminutiae - July 31, 2022 Category: Neurology Source Type: blogs
Normal Pressure Hydrocephalus (NPH) : MRI
History:A 55 years female presented with dementia and gait imbalanceFindings:There is ventricular dilatation, dysproportionate to the cerebral atrophy. No significant periventricular ooze. Bowing of the corpus callosum. A classical T2 hypointense jet at 4th ventricle. Features are characteristic of normal pressure hydrocephalus (NPH)Diagnosis:Normal Pressure Hydrocephalus (NPH)Extra EdgeClassical clinical triad?Dementia, ataxia, urinary incontinence. The most characteristic MRI sign?T2 hypointense jet at 4th ventricleWhich special MRI study is helpful and how?CSF flow study. To predict success of shunt procedure...
Source: Sumer's Radiology Site - March 2, 2022 Category: Radiology Authors: Sumer Sethi Source Type: blogs
March 2021: The Toxicity of Fire Smoke
A 54-year-old man was brought to the ED unresponsive by paramedics after his neighbors called 911 because they smelled smoke in his apartment. The patient was found unconscious in his living room, and a fire was burning in an adjoining room.His initial vital signs were a blood pressure of 115/80 mm Hg, a heart rate of 120 bpm, a respiratory rate of 30 bpm, an SPO2 of 94% on a nonrebreather, and a temperature of 98.9° F. The patient was unresponsive to verbal and physical stimuli but had spontaneous respirations. His nose and mouth were filled with soot, his lungs had trace wheezes, and his skin appeared flushed.What toxin...
Source: The Tox Cave - March 1, 2021 Category: Emergency Medicine Tags: Blog Posts Source Type: blogs
February 2021: Clinical Presentation Provides Clue to Toxicity
A 43-year-old man with a history of bipolar disorder, hypertension, and asthma presented with altered mental status and a tremor. He reported increasing fatigue and hand tremors for one day. He said he and his family recently had food poisoning with vomiting and diarrhea for several days. Those symptoms had resolved. He continued to take all of his prescribed medications, which included lithium carbonate (Lithobid) 800 mg BID and amlodipine 10 mg daily.His initial vital signs were a heart rate of 104 bpm, a blood pressure of 136/82 mm Hg, a respiratory rate of 16 bpm, an oxygen saturation of 99% on room air, and a temperat...
Source: The Tox Cave - January 29, 2021 Category: Emergency Medicine Tags: Blog Posts Source Type: blogs
Fight Aging! Newsletter, October 19th 2020
In conclusion, we found that regardless of the presence of multimorbidity, engaging in a healthier lifestyle was associated with up to 6.3 years longer life for men and 7.6 years for women; however, not all lifestyle risk factors equally correlated with life expectancy, with smoking being significantly worse than others.
A Hydrogel Scaffold to Encourage Peripheral Nerve Regeneration
https://www.fightaging.org/archives/2020/10/a-hydrogel-scaffold-to-encourage-peripheral-nerve-regeneration/
The nervous system of mammals is poorly regenerative at best. The use of implantable scaffold materials is one of th...
Source: Fight Aging! - October 18, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
G3BP1 is Required for the Senescence-Associated Secretory Phenotype
In this study, we assessed the role of G3BP1 as a regulator of the deleterious effects of senescent cells. We show that G3BP1 is required for the activation of the senescent-associated secretory phenotype (SASP). During senescence, G3BP1 achieves this effect by promoting the association of the cyclic GMP-AMP synthase (cGAS) with cytosolic chromatin fragments. In turn, G3BP1, through cGAS, activates the NF-κB and STAT3 pathways, promoting SASP expression and secretion. G3BP1 depletion or pharmacological inhibition impairs the cGAS-pathway preventing the expression of SASP factors without affecting cell commitment to senesc...
Source: Fight Aging! - October 13, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
