Mayo Clinic: diagnostic, therapeutic advance for rare neurodegenerative disorder
(Mayo Clinic) Mayo Clinic researchers, along with national and global collaborators, have developed a potential test for Machado-Joseph disease, or spinocerebellar ataxia type 3 (SCA3) ? a disease that has no cure. They also have clarified the role of a gene target associated with the disease. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - October 21, 2020 Category: International Medicine & Public Health Source Type: news
Toxin-induced cerebellar disorders - Dolbec K, Dobbs MR, Ibraheem M.
The cerebellum plays an important role in motor and nonmotor systems, with damage resulting in clinical manifestations presenting as weakness, ataxia, dysarthria, and nystagmus. There are numerous environmental and industrial agents as well as medications ... (Source: SafetyLit)
Source: SafetyLit - October 14, 2020 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
BioShin, Biohaven's Asia-Pacific Subsidiary, Raises $60M in Series A Funding to Advance Neuroscience Pipeline in Asia-Pacific Region
Initiating NURTEC ODT Phase 3 study for acute migraine in China and Korea, and China registrational study of troriluzole in Spinocerebellar Ataxia in 4Q20
Named Donnie McGrath as BioShin President and Executive Chairman, and Karl Lintel as BioShin Chief... Biopharmaceuticals, Personnel, Venture Capital Biohaven Pharmaceutical Holding Company, BioShin , NURTEC ODT (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - September 28, 2020 Category: Pharmaceuticals Source Type: news
Unintentional overdose of hyoscine hydrobromide in a young child - Xuereb G, Calleja T, Borg J, Pace D.
A 4-year-old girl presented with confusion, ataxia and hallucinations 3 hours after an accidental overdose of 108 μg per kg of hyoscine hydrobromide (Kwells Kids). She was hypotensive and tachycardic at presentation. Investigations revealed QTc prolongati... (Source: SafetyLit)
Source: SafetyLit - September 18, 2020 Category: International Medicine & Public Health Tags: Age: Infants and Children Source Type: news
Artificial intelligence and fractal dimension for monitoring ataxia
(Universit à di Bologna) A new Unibo-led project won the Spring Seed Grant by Telethon Foundation. Researchers will work to develop innovative techniques and cutting-edge computational approaches to fight rare and extremely debilitating diseases such as Friedreich's and spinocerebellar ataxia. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - September 18, 2020 Category: International Medicine & Public Health Source Type: news
Gene therapy corrects the cardiac effects of Friedreich's ataxia
(Mary Ann Liebert, Inc./Genetic Engineering News) Gene therapy was successfully used to overcome the cardiac effects of Freidreich's ataxia (FA) in a mouse model of the disease (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - September 18, 2020 Category: International Medicine & Public Health Source Type: news
New molecule to repair and restore brain and spinal cord function
A molecule created by researchers can restore lost connections in the spinal cord and brain of mice with neurological disorders including cerebellar ataxia, Alzheimer’s disease and spinal cord injury. (Source: Medical Research Council General News)
Source: Medical Research Council General News - August 27, 2020 Category: Research Source Type: news
A synthetic synaptic organizer protein restores glutamatergic neuronal circuits
Neuronal synapses undergo structural and functional changes throughout life, which are essential for nervous system physiology. However, these changes may also perturb the excitatory–inhibitory neurotransmission balance and trigger neuropsychiatric and neurological disorders. Molecular tools to restore this balance are highly desirable. Here, we designed and characterized CPTX, a synthetic synaptic organizer combining structural elements from cerebellin-1 and neuronal pentraxin-1. CPTX can interact with presynaptic neurexins and postsynaptic AMPA-type ionotropic glutamate receptors and induced the formation of excita...
Source: ScienceNOW - August 26, 2020 Category: Science Authors: Suzuki, K., Elegheert, J., Song, I., Sasakura, H., Senkov, O., Matsuda, K., Kakegawa, W., Clayton, A. J., Chang, V. T., Ferrer-Ferrer, M., Miura, E., Kaushik, R., Ikeno, M., Morioka, Y., Takeuchi, Y., Shimada, T., Otsuka, S., Stoyanov, S., Watanabe, M., T Tags: Biochemistry, Neuroscience, Online Only r-articles Source Type: news
Biotech Vico Therapeutics raises $31 million (27 million) in Series A financing round to advance therapies for rare central nervous system diseases
AON-platform with focus on therapies nearing phase I trials for forms of Spinocerebellar Ataxia and Huntington Disease
Other early discovery stage RNA editing platform focuses on RETT syndrome
Funding led by LSP, co-led by Kurma Partners, supported b... Biopharmaceuticals, Neurology, Venture Capital Vico Therapeutics, RNA modulating therapies (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - July 29, 2020 Category: Pharmaceuticals Source Type: news
Exercise offers 'profound' benefits for Friedreich's ataxia, research suggests
(University of Virginia Health System) Well-timed exercise programs may slow the progression of Friedreich's ataxia, which robs patients of their ability to walk, new research suggests. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - June 16, 2020 Category: International Medicine & Public Health Source Type: news
A natural amino acid could be a novel treatment for polyglutamine diseases
(Osaka University) Researchers from Osaka University, National Center of Neurology and Psychiatry, and Niigata University identified the amino acid arginine as a potential disease-modifying drug for polyglutamine diseases, including familial spinocerebellar ataxia and Huntington disease. Using various mice models of polyglutamine diseases, they showed that arginine prevents polyglutamine protein aggregation, improves motor function and suppresses neurodegeneration of mice. The results of this study could facilitate the clinical use of arginine for polyglutamine diseases that are, to date, incurable. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - May 25, 2020 Category: Biology Source Type: news
Genetic doppelgaengers: Emory research provides insight into two neurological puzzles
(Emory Health Sciences) Insight into the pathological mechanisms behind two devastating neurodegenerative diseases: the most common inherited form of amyotrophic lateral sclerosis/ frontotemporal dementia (ALS/FTD) and spinocerebellar ataxia type 36 (SCA36). Expanded repeats lead to peptide gobbledygook in both, but with critical differences. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 5, 2020 Category: International Medicine & Public Health Source Type: news
Pediatric perampanel poisoning - Qozi M, Cantrell FL.
Highlights
• 0.77 mg/kg perampanel caused drowsiness, ataxia and bradycardia in a child.
• 0.25 mg/kg perampanel caused quick onset ataxia in a child that resolved in 6 h.
• Pediatric perampanel exposures can resemble benzodiazapine exposure... (Source: SafetyLit)
Source: SafetyLit - May 4, 2020 Category: International Medicine & Public Health Tags: Age: Infants and Children Source Type: news
Some COVID Patients Develop Guillain-Barre
The symptoms of the disorder "include weakness, areflexia [absence of reflexes], paresthesia [tingling], and in some cases facial weakness and ataxia [poor balance]," Geraci said. (Source: WebMD Health)
Source: WebMD Health - April 21, 2020 Category: Consumer Health News Source Type: news
Progressive ataxia and falls in a 62 year old woman - Jedidi Z, Bianchi E, Moonen V, Jedidi H, Serre CH, Maquet P, Moonen G.
We discuss the diagnostic workup of a 62 year old woman without any significant past medical history. We take this opportunity to point out three aspects : 1. The necessary contextualization of the whole process allowing to avoid unrealistic differentials;... (Source: SafetyLit)
Source: SafetyLit - March 16, 2020 Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
