Horizon Pharma plc to Acquire Worldwide Rights to Interferon Gamma-1b From Boehringer Ingelheim International GmbH
Also Licenses Rights to Patents and Pending Applications Covering Methods for Treating Friedreich's Ataxia With Interferon Gamma-1b; Company Currently Owns the Rights to Interferon Gamma-1b Under the Trade Name ACTIMMUNE(R) in the United States, Canada and... Biopharmaceuticals, Licensing, AcquisitionsHorizon Pharma, Boehringer Ingelheim, interferon gamma-1b (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - May 19, 2016 Category: Pharmaceuticals Source Type: news

The interrelationship between disease severity, dynamic stability, and falls in cerebellar ataxia - Schniepp R, Schlick C, Pradhan C, Dieterich M, Brandt T, Jahn K, Wuehr M.
This study systematically correlated the clinical rat... (Source: SafetyLit)
Source: SafetyLit - May 19, 2016 Category: Global & Universal Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news

Immune system 'plays a role in dementia'
Conclusion This review presents evidence supporting the idea that the innate immune system is involved in a range of neurodegenerative conditions, such as Alzheimer's and Parkinson's. Reviews like this are very useful at summarising the current state of science in an area, but may miss important research, unless they are systematic. This review was openly one-sided, transparently exploring the evidence behind one hypothesis. While there is nothing wrong with that, a more systematic and balanced review would add the extra value of being able to discuss alternative ideas and find out how much evidence stacks up behind each...
Source: NHS News Feed - May 13, 2016 Category: Consumer Health News Tags: Neurology Older people Source Type: news

Horizon Pharma completes patent enrolment for Phase lll trial of actimmuneto treat Friedreich's Ataxia
Ireland-based biopharmaceutical company Horizon Pharma has completed its target enrolment of 90 patients for Phase lll trial of actimmune (interferon gamma-1b) to treat Friedreich's Ataxia (FA) disease. (Source: Drug Development Technology)
Source: Drug Development Technology - May 5, 2016 Category: Pharmaceuticals Source Type: news

Metronidazole-induced cerebellar syndrome
3.5 out of 5 stars Metronidazole-Associated Encephalopathy. Farmakiotis D, Zeluff B. N Engl J Med 2016 Apr 14;374:1465 Full Text            Exposure to metronidazole (Flagyl) can precipitate a subacute cerebellar syndrome, typically manifested with dysarthria and ataxia, with or without cognitive impairment. This adverse effect is uncommon and little-appreciated. Although usually associated with prolonged exposure to the antibiotic for treatment of conditions such as abscesses of Clostridium difficile-associated diarrhea and occurring after total cumulative dose > 20 gm, the syndrome can occur after lower dose...
Source: The Poison Review - April 15, 2016 Category: Toxicology Authors: Leon Gussow Tags: Medical acute cerebellar syndrome encephalopathy metronidazole miri neurotoxicity Source Type: news

UCLA research suggests that gut bacteria could help prevent cancer
Researchers have shown that various types of intestinal bacteria might be factors in both causing and preventing obesity, and in other conditions and diseases. Now, a UCLA study suggests that it could also potentially be used to reduce the risk for some types of cancer. The research, published online April 13 in the peer-reviewed journal PLOS ONE, offers evidence that anti-inflammatory “health beneficial” gut bacteria can slow or stop the development of some types of cancer. Ultimately, doctors might be able to reduce a person’s risk for cancer by analyzing the levels and types of intestinal bacteria in the body, a...
Source: UCLA Newsroom: Health Sciences - April 13, 2016 Category: Universities & Medical Training Source Type: news

Exome sequencing improves doctors’ ability to diagnose hard-to-pin-down neurogenetic disorders
UCLA researchers have found that a state-of-the-art molecular genetic test greatly improves the speed and accuracy with which they can diagnose neurogenetic disorders in children and adults. The discovery could lead directly to better care for people with rare diseases like spinocerebellar ataxia, leukodsystrophy, spastic paraplegia and many other conditions. The test, called exome sequencing, involves determining the order of all of the genes in a person’s genome. When used in concert with a complete patient evaluation and family medical history, the approach can help doctors identify disorders that may have gone undiag...
Source: UCLA Newsroom: Health Sciences - April 5, 2016 Category: Universities & Medical Training Source Type: news

Biodex fall risk assessment in the elderly with ataxia: a new age-dependent derived index in rehabilitation: an observational study - Prometti P, Olivares A, Gaia G, Bonometti G, Comini L, Scalvini S.
The aim of this study was to evaluate if the Biodex Fall Risk Assessment could provide an age-adjusted index useful for classifying patients at "risk of fall."This was a cohort study conducted on 61 chronic patients, in stable conditions, having a history ... (Source: SafetyLit)
Source: SafetyLit - March 25, 2016 Category: Global & Universal Tags: Age: Elder Adults Source Type: news

Genetic Cause of Spinocerebellar Ataxia (SCA) Identified
Researchers identify new mutation responsible for Spinocerebellar Ataxia (SCA), a degenerative and ultimately fatal movement disorder (Source: Disabled World)
Source: Disabled World - March 14, 2016 Category: Disability Tags: Medical Research Source Type: news

MedlinePlus: Ataxia telangiectasia
(Source: NLM General Announcements)
Source: NLM General Announcements - March 11, 2016 Category: Databases & Libraries Source Type: news

UT Southwestern scientists find potential treatment for Friedreich's ataxia
(UT Southwestern Medical Center) Researchers at UT Southwestern Medical Center have identified synthetic RNA and DNA that reverses the protein deficiency causing Friedreich's ataxia, a neurological disease for which there is currently no cure. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - February 16, 2016 Category: Biology Source Type: news

Children's Guaifenesin Grape Liquid and Guaifenesin DM Cherry Liquid by Perrigo Company: Recall - Potential Defect with Dosage Cup
An overdose of Guaifenesin DM may cause hyper excitability, rapid eye movements, changes in muscle reflexes, ataxia, dystonia, hallucinations, stupor, and coma. (Source: FDA MedWatch)
Source: FDA MedWatch - January 13, 2016 Category: American Health Source Type: news

Recall Issued For Children’s Cold Medicine
BOSTON (CBS) — A recall for a children’s cold medicine sold by retailers like CVS and Stop and Shop has been issued. In a release posted on the company’s website, Perrigo Company said they had issued a recall for two batches of their children’s guaifenesin grape liquid and three batches of their children’s guaifenesin DM cherry liquid. Both products are sold in 4 oz. bottles with a dosage cup included in the package. The recall was issued because the markings on some of the dosage cups are inaccurate–which could lead to overdoses. “There have been no reports of adverse events to...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - January 12, 2016 Category: Consumer Health News Authors: Jon Palmer Tags: Health Local News Syndicated Local drug recall Perrigo Source Type: news

Miller Fisher Syndrome: General Overview & Information
Miller Fisher Syndrome or, 'MFS,' is a post-infectious, immune mediated neuropathy characterized in typical instances by the clinical triad of ataxia, areflexia and ophthalmoplegia. MFS is considered to be a variant of Guillain-Barre syndrome or, 'GBS.' The clinical symptoms usually develop within days and improve spontaneously or following treatment within a period of weeks. People with MFS often show only part of the clinical triad. (Source: Disabled World)
Source: Disabled World - December 22, 2015 Category: Disability Tags: Neurological Disorders Source Type: news