Fight Aging! Newsletter, May 27th 2019

In this study, we found that cofilin competes with tau for direct microtubule binding in vitro, in cells, and in vivo, which inhibits tau-induced microtubule assembly. Genetic reduction of cofilin mitigates tauopathy and synaptic defects in Tau-P301S mice and movement deficits in tau transgenic C. elegans. The pathogenic effects of cofilin are selectively mediated by activated cofilin, as active but not inactive cofilin selectively interacts with tubulin, destabilizes microtubules, and promotes tauopathy. These results therefore indicate that activated cofilin plays an essential intermediary role in neurotoxic signaling that promotes tauopathy. Reviewing the Reserve Supply of Immature Neurons in the Adult Brain https://www.fightaging.org/archives/2019/05/reviewing-the-reserve-supply-of-immature-neurons-in-the-adult-brain/ To what degree can the adult brain restructure and regenerate itself? In one sense the components of the central nervous system, brain included, are clearly among the least regenerative of tissues in mammalian species. In another sense the brain is capable of significant compensatory change following damage. Further, the normal operation of the brain over time depends upon the plasticity of neural circuits in response to changing circumstances: learning, memory, and so forth. The authors of today's open access research propose that these capacities for regeneration and change may arise not just from a supply of daughter cells create...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs

Related Links:

Publication date: Available online 20 July 2019Source: European UrologyAuthor(s): Elise De Bleser, Barbara Alicja Jereczek-Fossa, David Pasquier, Thomas Zilli, Nicholas Van As, Shankar Siva, Andrei Fodor, Piet Dirix, Alfonso Gomez-Iturriaga, Fabio Trippa, Beatrice Detti, Gianluca Ingrosso, Luca Triggiani, Alessio Bruni, Filippo Alongi, Dries Reynders, Gert De Meerleer, Alessia Surgo, Kaoutar Loukili, Raymond MiralbellAbstractBackgroundStereotactic body radiotherapy (SBRT) and elective nodal radiotherapy (ENRT) are being investigated as metastasis-directed treatments in oligorecurrent prostate cancer (PC); however, comparat...
Source: European Urology - Category: Urology & Nephrology Source Type: research
ConclusionsRemission of type 2 diabetes 5 years after bariatric surgery was associated with improvements in albuminuria and stabilized prognostic risk for CKD, but not with eGFR. Lower kidney function and greater prognostic risk at the time of bariatric surgery was linked to a lower likelihood of diabetes remission. These results highlight the need to identify the mechanisms through which bariatric surgery may delay the long-term progression of CKD in type 2 diabetes.
Source: American Journal of Kidney Diseases - Category: Urology & Nephrology Source Type: research
Conclusions: This study highlights the need for more research and interventions for one of the fastest growing subgroups within the TBI population. PMID: 31322004 [PubMed - as supplied by publisher]
Source: Brain Injury - Category: Neurology Tags: Brain Inj Source Type: research
Authors: Medeiros CSP, Pacheco TBF, Cavalcanti FADC, Cacho RO, Bezerra AMDS Abstract Primary Objective: To compare the level of motor, sensory and functional impairment of individuals hospitalized in a stroke unit in Brazil at the time of admission and the profile observed at hospital discharge. Design: Observational and longitudinal outcome study. Methods and Procedure: We assessed 41 patients with ischemic stroke at admission and hospital discharge by using the National Institute of Health Stroke Scale (NIHSS), Fugl-Meyer Physical Performance Scale (FM), Functional Independence Measure (FIM) and Modified Rankin S...
Source: Brain Injury - Category: Neurology Tags: Brain Inj Source Type: research
ConclusionWe performed cholecystectomy by using IFC to identify the aberrant subvesical bile duct. To the best of our knowledge, this is the first report showing the fluorescence image of an aberrant subvesical bile duct in a state of nature.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
ConclusionVascular surgery in TA cases becomes an option when the patient does not improve clinically after administration of medical treatment. Although endovascular management has fewer complications, the rate of restenosis is higher. Patients at risk of restenosis and who have increased perioperative vascular risk can benefit from open surgical procedures. Surgical management should be tailored to the patient’s needs.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
ConclusionThe incidence of midline and lateral port site recurrence after laparoscopy for diagnosis or resection of ovarian cancer has not been determined. Limitation of trochar sites to the midline may reduce the extent of abdominal wall disease spread.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
ConclusionThere is evidence that newborns have a much higher potential for wound healing than adults. Proper position in long-term immobilization of toes is important to prevent scar contracture and deformity.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
ConclusionsPeritoneal tunnels in the inguinal region or at the porta hepatis should be opened by surgical dissection so that all foci of peritoneal metastases are removed at a complete cytoreductive surgery and these sites treated with chemotherapy.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
ConclusionThese cases are reported because of their rare location and presentation since few cases of bilateral cholesterol granuloma have been reported in the literature.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
More News: Accidents | Advertising | African Health | Age-Related Macular Degeneration (AMD) | Alzheimer's | Arthritis | Biochemistry | Biology | Biomedical Science | Biotechnology | Blindness | Brain | Brain Cancers | Budgets | Cancer | Cancer & Oncology | Cancer Therapy | Cancer Vaccines | Cardiology | Cardiovascular | Cataracts | Chemistry | Child Development | Children | Cholesterol | Clinical Trials | Complementary Medicine | Coronary Heart Disease | Cytomegalovirus | Databases & Libraries | Dementia | Depression | Diabetes | Diabetes Mellitus | Diabetes Type 2 | Diarrhoea | Diets | Disability | Eating Disorders & Weight Management | Endocrinology | Environmental Health | Epidemiology | Epithelial Cancer | Eyes | Fatty Liver Disease (FLD) | Funding | Fundraising | Gastroschisis Repair | Gene Therapy | Genetics | Government | Harvard | Heart | Heart Disease | Heart Valve Surgery | Hypertension | Immunotherapy | Infectious Diseases | Inflammatory Bowel Disease | Influenza | Influenza Vaccine | Insulin | Japan Health | Learning | Legislation | Liver | Liver Disease | Men | Mitochondria | Mitochondrial Disease | Molecular Biology | Multiple Sclerosis | Neurology | Neuroscience | Nightmares | Nutrition | Obesity | Opthalmology | Orthopaedics | Osteoarthritis | Parkinson's Disease | Pathology | Pensions | Pneomococcal Vaccine | Pneumonia | Politics | Research | Rheumatoid Arthritis | Rheumatology | Science | Skin | Sports Medicine | Statin Therapy | Statistics | Stem Cell Therapy | Stem Cells | Study | Suicide | Tax | Toxicology | Tuberculosis | Universities & Medical Training | Urology & Nephrology | USA Health | Vaccines | Veterinary Research | Veterinary Vaccinations | Vitamin A | Women