Inhibiting post-translational modifications may lower oxidative stress in the aging eye
(Bentham Science Publishers) Advanced age is the largest risk factor for age-related macular degeneration (AMD). Sumoylation is a reversible post-translational modification that conjugates small peptide, small ubiquitin-like modifier (SUMO), to a target protein. Our data indicate sumoylation critically regulates retina and RPE aging and that targeting sumoylation process may provide potential therapeutic strategy for AMD treatment. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 11, 2019 Category: International Medicine & Public Health Source Type: news

Ocular Therapeutix doses first wet-AMD patient in implant trial
Ocular Therapeutix (NSDQ:OCUL) said today that it dosed the first patient in a study of its OTX-TKI tyrosine kinase inhibitor implant. The Phase I trial is slated to assess the bioresorbable device’s safety, durability and tolerability in people with wet age-related macular degeneration. Get the full story at our sister site, Drug Delivery Business News. The post Ocular Therapeutix doses first wet-AMD patient in implant trial appeared first on MassDevice. (Source: Mass Device)
Source: Mass Device - February 20, 2019 Category: Medical Devices Authors: Sarah Faulkner Tags: Clinical Trials Drug-Device Combinations Featured Implants Optical/Ophthalmic Pharmaceuticals Wall Street Beat oculartherapeutix Source Type: news

Scientists launch first attempt to halt most common cause of age-related blindness with gene therapy
Surgeons at Oxford University have launched their first attempt at halting age-related macular degeneration, which is the most common cause of blindness and affects 600,000 people in the UK. (Source: the Mail online | Health)
Source: the Mail online | Health - February 18, 2019 Category: Consumer Health News Source Type: news

Protect Your Aging Eyes From Macular Degeneration
FRIDAY, Feb. 15, 2019 -- Age-related macular degeneration (AMD) is an incurable eye disease that affects millions of older Americans, but there are a number of things you can do to reduce your risk, a vision expert says. AMD causes blurred central... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - February 15, 2019 Category: General Medicine Source Type: news

Single-Cell Transcriptomic Atlas of the Human Retina Identifies Cell Types Associated with Age-Related Macular Degeneration
ACD Bio invites you to join them for an educational webinar (Source: The Scientist)
Source: The Scientist - February 13, 2019 Category: Science Tags: Sponsored Webinars Source Type: news

Mayo Clinic Minute: What you need to know about wet macular degeneration
Millions of people deal with age-related macular degeneration as they get older, but many don't understand the difference between types of the condition or what they can do to lessen the effects. Dr. Sophie Bakri, a Mayo Clinic ophthalmologist and retina specialist, explains the differences between wet macular degeneration and dry macular degeneration. Watch: Mayo [...] (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - February 13, 2019 Category: Databases & Libraries Source Type: news

Mayo Clinic Minute: What you need to know about dry macular degeneration
Millions of people deal with age-related macular degeneration as they get older, but many don't understand the difference between types of the condition or what they can do to lessen the effects. Dr. Sophie Bakri, a Mayo Clinic ophthalmologist and retina specialist, explains the differences between wet macular degeneration and dry macular degeneration. Watch: Mayo [...] (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - February 12, 2019 Category: Databases & Libraries Source Type: news

NIH researchers home in on genes linked to age-related macular degeneration
Findings point to potential treatment strategies. (Source: National Institutes of Health (NIH) News Releases)
Source: National Institutes of Health (NIH) News Releases - February 11, 2019 Category: American Health Source Type: news

NIH researchers home in on genes linked to age-related macular degeneration
(NIH/National Eye Institute) National Eye Institute scientists led a collaborative study and zeroed in on genes associated with age-related macular degeneration (AMD), a leading cause of vision loss and blindness among people age 65 and older. These findings provide a more expanded and in-depth picture of the genetic contributions to AMD, and they present new pathways for treatment development. The study was published Feb. 11 in Nature Genetics. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 11, 2019 Category: International Medicine & Public Health Source Type: news

Leading eye hospital has been accused of ‘robbing from the blind’
EXCLUSIVE: June Hanson, from a village near Aylesbury, who has age-related macular degeneration, paid £12,000 to the London Eye Hospital for lenses to improve her sight. (Source: the Mail online | Health)
Source: the Mail online | Health - February 4, 2019 Category: Consumer Health News Source Type: news

Ranibizumab and Aflibercept Prompt Comparable Visual Gain in AMD Ranibizumab and Aflibercept Prompt Comparable Visual Gain in AMD
In patients with neovascular age-related macular degeneration (nAMD), aflibercept and ranibizumab achieve similar average visual acuity increases, according Australian researchers.Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - January 31, 2019 Category: Consumer Health News Tags: Medscape Today News Source Type: news

What Are Common Causes of Blindness in Children?
Discussion According to the World Health Organization, about 1.3 billion people have some form of visual impairment. Most people with visual impairments are>50 years old, more are female than male, and more live in resource-limited areas than resource-rich areas. Most visual impairments are avoidable (80%) in all age groups with the leading causes globally and across ages being uncorrected refractive errors and cataracts. The most common causes of blindness are: Refractive errors, uncorrected Cataract Age-related macular degeneration Glaucoma Diabetic retinopathy Corneal opacity Trachoma The exact numbers vary by regi...
Source: PediatricEducation.org - January 28, 2019 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

It's possible: Nutritional recommendations that prevent age-related macular degeneration
(Natural News) Saffron is a highly-prized spice with many uses. However, according to several studies, the spice can also be used to reduce your risk of developing age-related macular degeneration. Macular degeneration is the leading cause of blindness in adults aged 50 and older. In the U.S., over 11 million older Americans have some degree of... (Source: NaturalNews.com)
Source: NaturalNews.com - January 26, 2019 Category: Consumer Health News Source Type: news

Study identifies new genes associated with the leading cause of blindness
(University of Liverpool) A new study, published in Clinical Epigenetics, identifies genes associated with Age-related Macular Degeneration (AMD) that could represent new targets for future drug development. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - January 22, 2019 Category: International Medicine & Public Health Source Type: news

Stem Cell Therapy Shows Early Promise Against Macular Degeneration
THURSDAY, Jan. 17, 2019 -- Age-related macular degeneration is the leading cause of vision loss in seniors, and existing treatments are few. But now, experiments in pigs and rats suggest that stem cell therapy might help curb at least one form of... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - January 17, 2019 Category: General Medicine Source Type: news

Keep your eyesight healthy well beyond your sunset years with the Mediterranean diet
(Natural News) Nutritionists across the world highly recommend the Mediterranean diet, and research is finding more reasons to follow it. A team of scientists from the University of Bordeaux and Erasmus University Medical Center discovered that this type of diet reduces the risk of age-related macular degeneration (AMD), a leading cause of blindness in the U.S. According to... (Source: NaturalNews.com)
Source: NaturalNews.com - January 17, 2019 Category: Consumer Health News Source Type: news

Researchers assess whether AMD patients could self-test vision
A study is investigating whether home eye tests will benefit patients with wet age-related macular degeneration and, as a result, significantly reduce the burden on the NHS. (Source: Nursing Times)
Source: Nursing Times - December 24, 2018 Category: Nursing Source Type: news

Age-Related Macular Degeneration: 5 Things to Know Age-Related Macular Degeneration: 5 Things to Know
A guide to the latest on this chronic disease, from emerging treatments to the risk factors to be on the lookout for.Medscape Ophthalmology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - December 14, 2018 Category: Consumer Health News Tags: Ophthalmology Commentary Source Type: news

LumiThera inks Italian Valeda distro deal
LumiThera said today that it inked a deal with ophthalmology distributor Miloftalmica to be the exclusive distributor of the Valeda light delivery system, intended to treat dry age-related macular degeneration, across Italy. Therapy using the Valeda light delivery system consists of a series of light-based treatments to the retinal cells, which Seattle-based LumiThera claims improves energy production and can be used to address inflammation, ischemia and metabolic dysfunction that contribute to the disease. “Our new exciting partnership with LumiThera is fully consistent with the strategy and growth objectives of Mil...
Source: Mass Device - December 11, 2018 Category: Medical Devices Authors: Fink Densford Tags: Business/Financial News Distribution Optical/Ophthalmic LumiThera Source Type: news

Reduce your risk of macular degeneration by a whopping 61% just by eating oranges
(Natural News) In the U.S., more people lose their vision because of age-related macular degeneration than glaucoma and cataracts combined, says the National Institute of Health (NIH). This makes the condition the leading cause of blindness among people older than 60. Macular degeneration is irreversible, but there are steps you can take to lower your... (Source: NaturalNews.com)
Source: NaturalNews.com - December 4, 2018 Category: Consumer Health News Source Type: news

Notal Vision snags breakthrough designation for home OCT system
Ophthalmic diagnostic services company Notal Vision said it has won breakthrough device designation for its artificial-intelligence-aided macular degeneration diagnostic device. Privately-held Notal (Manassas, Va.) said its home-based optical coherence tomography (OCT) system was designed to automatically identify intra- and/or subretinal fluid in the central 10 degrees of eyes diagnosed with exudative age-related macular degeneration (eAMD). The Notal Home OCT device is intended for testing at home between regularly scheduled clinic assessments and not intended to replace standard-of-care regularly schedule...
Source: Mass Device - December 4, 2018 Category: Medical Devices Authors: Nancy Crotti Tags: Blog Business/Financial News Food & Drug Administration (FDA) Optical/Ophthalmic Vision Notal Vision Source Type: news

MDI Biological Laboratory scientist receives scientific innovation award
(Mount Desert Island Biological Laboratory) Vicki P. Losick, Ph.D., has been named the inaugural recipient of an award from the William Procter Scientific Innovation Fund. The award will support her research at the MDI Biological Laboratory on age-related macular degeneration (AMD), a leading cause of blindness in older people. Losick will establish a fruit fly model for AMD that she will use to study the genetics underlying the disease, and potentially to test for interventions to prevent or reverse it. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - November 30, 2018 Category: International Medicine & Public Health Source Type: news

Modeling the most common form of vision loss in older adults
(University of Pennsylvania) Age-related macular degeneration is the leading cause of vision loss in people older than 50. University of Pennsylvania biochemist Kathleen Boesze-Battaglia and colleagues have developed a model system that mimics many features of the human condition, giving scientists a platform to gain a deeper understanding of risk factors and possible treatments. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 21, 2018 Category: International Medicine & Public Health Source Type: news

Calcified Nodules in Drusen May Signal Progression of AMD
THURSDAY, Nov. 15, 2018 -- Calcified nodules in retinal drusen are linked to disease progression in patients with age-related macular degeneration (AMD), according to a study published in the Nov. 7 issue of Science Translational Medicine. Anna C.S.... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - November 15, 2018 Category: Pharmaceuticals Source Type: news

Change Within Eye A Hint of Macular Degeneration?
The investigators discovered that calcifications in the retina -- the thin layer of tissue that lines the back of the eye -- raise the risk of advanced age-related macular degeneration (AMD). (Source: WebMD Health)
Source: WebMD Health - November 9, 2018 Category: Consumer Health News Source Type: news

Calcified Nodules Linked to AMD Progression Calcified Nodules Linked to AMD Progression
Calcified nodules in the retinas of patients with age-related macular degeneration are linked to the progression to advanced stage disease, a study has shown.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - November 8, 2018 Category: Consumer Health News Tags: Ophthalmology News Source Type: news

Calcified eye spots linked to progession of macular degeneration
The composition of calcified nodules in eyes have been linked to the progression of age-related macular degeneration in retinas, according to a study. (Source: Health News - UPI.com)
Source: Health News - UPI.com - November 8, 2018 Category: Consumer Health News Source Type: news

Genentech touts data for refillable eye implant in wet-AMD trial
Roche‘s (OTC:RHHBY) Genentech touted additional positive data last week from a Phase II study of its Port Delivery System, a refillable eye implant designed to deliver ranibizumab to treat wet age-related macular degeneration. The company first reported top-line results from the Phase II Ladder study in July. The implant is intended to allow wet-AMD patients to go for months without needing to see an ophthalmologist for treatment; the current standard of care for wet-AMD patients involves monthly injections of therapy. Get the full story at our sister site, Drug Delivery Business News. The post Ge...
Source: Mass Device - October 29, 2018 Category: Medical Devices Authors: Sarah Faulkner Tags: Clinical Trials Drug-Device Combinations Optical/Ophthalmic Pharmaceuticals Wall Street Beat Genentech Roche Source Type: news

Metformin lowers age-related macular degeneration risk
Research, presented at the American Academy of Ophthalmology Meeting, suggests that patients with type-2 diabetes who use metformin lower their risk of developing age-related macular degeneration. Med Page Today (Source: Society for Endocrinology)
Source: Society for Endocrinology - October 29, 2018 Category: Endocrinology Source Type: news

New STAIRWAY study data shows potential for extended durability with Roche ’s faricimab in neovascular age-related macular degeneration (nAMD)
Roche today announced positive results from the phase II STAIRWAY study which explored the extended durability of faricimab (RG7716) in the treatment of neovascular ( “wet”) age-related macular degeneration (nAMD), a leading cause of blindness globally in people aged 60 and over. (Source: Roche Media News)
Source: Roche Media News - October 29, 2018 Category: Pharmaceuticals Source Type: news

New STAIRWAY study data shows potential for extended durability with Roche ’s faricimab in neovascular age-related macular degeneration (nAMD)
Roche today announced positive results from the phase II STAIRWAY study which explored the extended durability of faricimab (RG7716) in the treatment of neovascular ( “wet”) age-related macular degeneration (nAMD), a leading cause of blindness globally in people aged 60 and over. (Source: Roche Investor Update)
Source: Roche Investor Update - October 29, 2018 Category: Pharmaceuticals Source Type: news

Fewer Injections With New Wet Macular Degeneration Therapies Fewer Injections With New Wet Macular Degeneration Therapies
New treatments in development — including gene therapy — will likely mean fewer injections for patients with neovascular age-related macular degeneration, studies indicate.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - October 28, 2018 Category: Consumer Health News Tags: Ophthalmology News Source Type: news

LumiThera inks distro deal with Nikon ’ s Optos
LumiThera said today it inked a distribution deal with Nikon (TYO:7731) subsidiary Optos to distribute its Valeda light delivery system intended for use in treating dry age-related macular degeneration. The deal will position Optos as the exclusive distributor of the device in 12 European countries, the Seattle-based company said. The device has already won CE Mark approval in the European Union, it added. “The distribution agreement with Optos allows LumiThera to begin commercialization throughout Europe and establishes a collaboration with a partner in the retinal imaging area. Optos i...
Source: Mass Device - October 24, 2018 Category: Medical Devices Authors: Fink Densford Tags: Business/Financial News Distribution Optical/Ophthalmic LumiThera Nikon Optos Inc. Source Type: news

Researchers develop new devices to test retinal cells
(Utah State University) Researchers at Utah State University have developed new devices to better understand the triggers of age-related macular degeneration (AMD) by mechanically stressing cells. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - October 24, 2018 Category: International Medicine & Public Health Source Type: news

Drug Pipeline for Macular Degeneration in Focus at AAO Drug Pipeline for Macular Degeneration in Focus at AAO
Updates from phase 3 trials of VEGF inhibitors for neovascular age-related macular degeneration, and a novel genetic treatment, will be highlighted at the American Academy of Ophthalmology meeting.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - October 19, 2018 Category: Consumer Health News Tags: Ophthalmology News Source Type: news

The dangers of blue light from digital devices: It can harm your eye health
(Natural News) Is your cellphone damaging your eyes? New research has highlighted yet another pitfall of modern technology: It’s slowly making you blind. A study just published in Scientific Reports has uncovered a sordid truth: Constant exposure to blue light from beloved cellphones and other devices leads to age-related macular degeneration, one of the leading causes... (Source: NaturalNews.com)
Source: NaturalNews.com - October 18, 2018 Category: Consumer Health News Source Type: news

Eating leafy greens could help prevent macular degeneration
A new study has shown that eating vegetable nitrates, found mainly in green leafy vegetables and beetroot, could help reduce your risk of developing early-stage age-related macular degeneration (AMD). Researchers at the Westmead Institute for Medical Research interviewed more than 2,000 Australian adults aged over 49 and followed them over a 15-year period. (Source: World Pharma News)
Source: World Pharma News - October 18, 2018 Category: Pharmaceuticals Tags: Featured Research Research and Development Source Type: news

Genentech kicks off Phase III trials for eye implant
Roche‘s (OTC:RHHBY) Genentech reported this week that the company launched three Phase III trials evaluating the Port drug-delivery implant in patients with wet age-related macular degeneration and diabetic macular edema. The device is a refillable eye implant designed to continuously release drugs over a period of several months. Get the full story at our sister site, Drug Delivery Business News. The post Genentech kicks off Phase III trials for eye implant appeared first on MassDevice. (Source: Mass Device)
Source: Mass Device - October 5, 2018 Category: Medical Devices Authors: Sarah Faulkner Tags: Clinical Trials Diabetes Drug-Device Combinations Optical/Ophthalmic Pharmaceuticals Wall Street Beat Genentech Roche Source Type: news

Mediterranean Diet May Help Preserve Your Vision
The Mediterranean diet’s combination of fruits, legumes, whole grains, olive oil and fish seems to reduce the risk of late-stage age-related macular degeneration, a new study finds. (Source: WebMD Health)
Source: WebMD Health - October 5, 2018 Category: Consumer Health News Source Type: news

Adherence to Mediterranean Diet Linked to Lower Risk for AMD
THURSDAY, Oct. 4, 2018 -- Higher adherence to the Mediterranean diet (MeDi) is associated with a reduced risk for incident advanced age-related macular degeneration (AMD), according to a study recently published in Ophthalmology. B énédicte M. J.... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - October 4, 2018 Category: Pharmaceuticals Source Type: news

A group of perfectly ordinary garden vegetables hold the key to preventing blindness
(Natural News) For many people, losing your eyesight is one of the strongest signs that you’re getting older. When you realize that you can no longer see as well as you once did, it’s easy to pass this off as a typical effect of aging, but the truth is that age-related macular degeneration, although common,... (Source: NaturalNews.com)
Source: NaturalNews.com - October 1, 2018 Category: Consumer Health News Source Type: news

NHS wins landmark High Court battle with two major drug firms
A judge rejected an action brought by Bayer and Novartis against 12 NHS clinical commissioning groups in north England relating to Avastin, an age-related macular degeneration drug. (Source: the Mail online | Health)
Source: the Mail online | Health - September 21, 2018 Category: Consumer Health News Source Type: news

Heidelberg Engineering wins FDA nod for upgraded eye imaging technology
Image of an eye using OCTA technology, courtesy of Heidelberg Engineering. The FDA has approved Heidelberg Engineering’s optical coherence tomography angiography module (OCTA), the company said today. The module is available for new and existing Spectralis upgradeable diagnostic imaging devices used to manage diabetic retinopathy, age-related macular degeneration and other macular diseases. OCTA is a noninvasive imaging technique that provides three-dimensional visualization of perfused ocular vasculature. Structural OCT uses light waves to take cross-section pictures of the retina, allowing the ophtha...
Source: Mass Device - September 20, 2018 Category: Medical Devices Authors: Nancy Crotti Tags: Blog Diagnostics Food & Drug Administration (FDA) Imaging Optical/Ophthalmic Vision heidelbergengineering Source Type: news

Pixium Vision ’s novel Prima chip helps patients see the light
Pixium Vision said today that its Prima miniature wireless photovoltaic sub-retinal implant has been activated in the first five patients. The patients all have severe vision loss from atrophic dry age-related macular degeneration. They are enrolled in a three-year clinical study in France to evaluate the safety and function of the Prima chip in eliciting visual light perception, the company said in a statement. All five reported seeing useful light patterns in areas where they had had no remaining light perception. The current study patients will be taught how to interpret their new artificial central macular pe...
Source: Mass Device - August 30, 2018 Category: Medical Devices Authors: Nancy Crotti Tags: Blog Clinical Trials Implants Vision Pixium Vision Source Type: news

FDA Approves New Eylea (aflibercept) Injection Dosing Schedule in Wet Age-Related Macular Degeneration
TARRYTOWN, N.Y., Aug. 17, 2018 /PRNewswire/ -- Regeneron Pharmaceuticals, Inc. (NASDAQ : REGN) today announced that the U.S. Food and Drug Administration (FDA) has approved a supplemental Biologics License Application (sBLA) for Eylea (aflibercept)... (Source: Drugs.com - New Drug Approvals)
Source: Drugs.com - New Drug Approvals - August 17, 2018 Category: Drugs & Pharmacology Source Type: news

Health Tip: Are You at Risk for Macular Degeneration?
-- Age-Related Macular Degeneration (AMD) is a leading cause of vision loss among people 50 and older, the U.S. National Eye Institute says. AMD damages the macula, a small spot near the center of the retina that's needed for sharp, central vision... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - August 15, 2018 Category: General Medicine Source Type: news

Three Eye Conditions Linked to Higher Alzheimer's Risk Three Eye Conditions Linked to Higher Alzheimer's Risk
More insight into the eye as a'window into the brain'comes from a study linking glaucoma, age-related macular degeneration, and diabetic retinopathy to a higher risk for Alzheimer's disease.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - August 14, 2018 Category: Consumer Health News Tags: Neurology & Neurosurgery News Source Type: news

Study Links 3 Eye Diseases, Alzheimer's
Patients with age-related macular degeneration, diabetic retinopathy or glaucoma had a 40 to 50 percent greater risk of Alzheimer's disease than those without the eye conditions, the authors of a new study report. (Source: WebMD Health)
Source: WebMD Health - August 12, 2018 Category: Consumer Health News Source Type: news

Viagra could be a new miracle cure for blindness, scientists claim  
The anti-impotence drug may stop age-related macular degeneration.   This follows a two-year trial led at Columbia University in New York. The condition is the UK’s leading cause of blindness. (Source: the Mail online | Health)
Source: the Mail online | Health - August 11, 2018 Category: Consumer Health News Source Type: news

Eye conditions provide new lens screening for Alzheimer's disease
(University of Washington Health Sciences/UW Medicine) A study of 3,877 randomly selected patients found a significant link between three degenerative eye diseases -- age-related macular degeneration, diabetic retinopathy and glaucoma -- and Alzheimer' disease. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - August 8, 2018 Category: International Medicine & Public Health Source Type: news