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Lab notes: DNA editing, dearth of new antibiotics and knowing your mind
This week ’s top story brings hope for millions of those who are unable to conceive. British scientists haverevealed the role of ‘master gene’ in human embryo development. The study marks a first for the UK and could help uncover the cause of recurrent miscarriages and improve fertility treatments. Scientists used Crispr/Cas9 gene-editing tool to make precise cuts in DNA and deactivate a gene called OCT4. The study showed this gene is critical for the embryo to develop and the results could help produce more effective IVF treatment. Meanwhile,the WHO has warned over the paucity of new antibiotics. In a re...
Source: Guardian Unlimited Science - September 22, 2017 Category: Science Authors: Tash Reith-Banks Tags: Science Source Type: news

How the Graham-Cassidy Proposal Would Hurt Communities of Color
The repeated efforts by Congress to repeal the Affordable Care Act (ACA) can feel endless — legislators keep reviving our deepest fears about how to keep our loved ones and ourselves healthy. Even though repeal was defeated in the Senate just a few months ago, there is a new bill that is as bad as, if not worse than, the previous version. Key Senators are ramming the legislation — known as Graham-Cassidy — through the chamber at warp speed. As two people who worked to make Obamacare a reality, we don’t like what we see. There will be devastating consequences for tens of millions of Americans &mdash...
Source: TIME.com: Top Science and Health Stories - September 22, 2017 Category: Consumer Health News Authors: Chris Lu, Kathy Ko Chin Tags: Uncategorized Health Care Source Type: news

Tuberculosis: Osmosis Study Video Tuberculosis: Osmosis Study Video
This video covers the pathophysiology of tuberculosis infection, as well as important complications, signs and symptoms, tests and procedures, and treatment.Osmosis (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - September 22, 2017 Category: Consumer Health News Tags: Med Students Commentary Source Type: news

Papworth Hospital granted royal title by Queen
Papworth Hospital opened as a tuberculosis colony and celebrates its 100th year in 2018. (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - September 21, 2017 Category: Consumer Health News Source Type: news

Antibacterial Agents in Clinical Development: An analysis of the antibacterial clinical development pipeline, including tuberculosis
The report shows a serious lack of new antibiotics under development to combat the growing threat of antimicrobial resistance. Most of the drugs currently in the clinical pipeline are modifications of existing classes of antibiotics and are only short-term solutions. (Source: HSR Information Central)
Source: HSR Information Central - September 21, 2017 Category: International Medicine & Public Health Source Type: news

Antibacterial Agents in Clinical Development: An analysis of the antibacterial clinical development pipeline, including tuberculosis
This report focuses on the lack of new antibiotics under development to combat the growing threat of antimicrobial resistance. The report found very few potential treatment options for those antibiotic-resistant infections identified by WHO as posing the greatest threat to health. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - September 21, 2017 Category: Consumer Health News Source Type: news

Namibia: Woman Keeps Going Despite Paralysis
[Namibian] About seven years ago, Martha Campbell (47) started losing control of her body below her waist because of "TB of the spine", doctors told her. (Source: AllAfrica News: Tuberculosis)
Source: AllAfrica News: Tuberculosis - September 21, 2017 Category: Infectious Diseases Source Type: news

Antibacterial Agents in Clinical Development: An Analysis of the Antibacterial Clinical Development Pipeline, Including Tuberculosis
World Health Organization. 09/2017 This 48-page report shows a serious lack of new antibiotics under development to combat the growing threat of antimicrobial resistance. It found very few potential treatment options for those antibiotic-resistant infections identified by the World Health Organization as posing the greatest threat to health, including drug-resistant tuberculosis, which kills around 250,000 people each year. The report identifies 12 classes of priority pathogens that are increasingly resistant to existing antibiotics and urgently in need of new treatments. (PDF) (Source: Disaster Lit: Resource Guide for Dis...
Source: Disaster Lit: Resource Guide for Disaster Medicine and Public Health - September 20, 2017 Category: International Medicine & Public Health Authors: The U.S. National Library of Medicine Source Type: news

Prioritization of Pathogens to Guide Discovery, Research and Development of New Antibiotics for Drug Resistant Bacterial Infections, Including Tuberculosis
World Health Organization. 09/2017 This 88-page report presents the priority pathogens to be targeted for research and development of new antibiotics to treat drug-resistant bacterial infections and tuberculosis. It acknowledges that viral, fungal, and parasitic infections may well need a similar strategy in the near future. It addresses Mycobacterium tuberculosis and other antibiotic-resistant bacteria, which have been overlooked until recently despite their considerable health and economic burden. (PDF) (Source: Disaster Lit: Resource Guide for Disaster Medicine and Public Health)
Source: Disaster Lit: Resource Guide for Disaster Medicine and Public Health - September 20, 2017 Category: International Medicine & Public Health Authors: The U.S. National Library of Medicine Source Type: news

Drug-resistant infections are a 'global health emergency': WHO
WHO found there is a lack of new treatments being developed to combat antibiotic-resistant infections, such as tuberculosis which kills around 250,000 people each year. (Source: The Economic Times)
Source: The Economic Times - September 20, 2017 Category: Consumer Health News Source Type: news

Too few antibiotics in pipeline to tackle global drug-resistance crisis, WHO warns
Nowhere near enough new drugs are currently in development says report, which calls for urgent investment and responsible use of existing antibioticsToo few antibiotics are in the pipeline to tackle the global crisis of drug resistance, which is responsible for the rise of almost untreatable infections around the world, the World Health Organisation (WHO) warns.Among the alarming diseases that are increasing and spreading ismulti-drug resistant tuberculosis (TB), which requires treatment lasting between nine and 20 months. There are 250,000 deaths a year from drug-resistant TB and only 52% of patients globally are successf...
Source: Guardian Unlimited Science - September 20, 2017 Category: Science Authors: Sarah Boseley Health editor Tags: Antibiotics Drug resistance Society Medical research Health Science World Health Organization Tuberculosis Microbiology Source Type: news

WHO: Not Enough Antibiotics in Pipeline to Curb Superbugs WHO: Not Enough Antibiotics in Pipeline to Curb Superbugs
Physicians need more weapons against drug-resistant tuberculosis and carbapenem-resistant bugs such as Enterobacteriaceae, according to the agency.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - September 19, 2017 Category: Consumer Health News Tags: Infectious Diseases News Source Type: news

The world is running out of antibiotics, WHO report confirms
A report, Antibacterial agents in clinical development – an analysis of the antibacterial clinical development pipeline, including tuberculosis, launched today by WHO shows a serious lack of new antibiotics under development to combat the growing threat of antimicrobial resistance. (Source: WHO news)
Source: WHO news - September 19, 2017 Category: International Medicine & Public Health Tags: antimicrobial resistance [subject], Press release [doctype] Source Type: news

Out of Step 2017: TB Policies in 29 Countries
Out of Step includes the results of a 29-country survey on national TB policies and practices. The report was created to identify gaps in implementation and monitor progress towards ending tuberculosis. (Source: PHPartners.org)
Source: PHPartners.org - September 19, 2017 Category: International Medicine & Public Health Source Type: news

Gates Foundation supports development of Immunocore ’s therapeutics for infectious diseases
Immunocore has secured up to $40m in investment from Bill& Melinda Gates Foundation to boost the development of soluble T-cell receptor (TCR)-based therapeutics to treat infectious diseases, in particular tuberculosis (TB) and human immunodeficiency … (Source: Pharmaceutical Technology)
Source: Pharmaceutical Technology - September 18, 2017 Category: Pharmaceuticals Source Type: news

TB: Rapid Test for Multidrug Resistance Shows Promise TB: Rapid Test for Multidrug Resistance Shows Promise
Study results suggest a new rapid test for tuberculosis resistance to multiple drugs could help guide point-of-care treatment and prevent the spread of resistance.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - September 15, 2017 Category: Consumer Health News Tags: Infectious Diseases News Source Type: news

"Hold Your Breath", paintings made by Russian artist while in a TB clinic
“Hold your Breath” presents the story of Russian artist Paulina Siniatkina’s fight against tuberculosis (TB). In 2015, Paulina spent 6 months and 17 days in a TB clinic in Moscow. She went through fear, misunderstanding, anger, despair, loneliness, silence, love, friendship and hope, and left the hospital with a series of artworks that tell the stories of people who shared her fate. She created these works of art to fight the stigma attached to TB. The exhibition "Hold your breath" has been travelling the world since then, fighting stigma and urging people not to be afraid to talk about TB. On...
Source: WHO Feature Stories - September 15, 2017 Category: International Medicine & Public Health Tags: communicable disease [subject], infectious diseases, tuberculosis [subject], tb, tuberculosis [subject], tb, European Region [region], Feature [doctype], Russian Federation [country] Source Type: news

Assay Can ID M. tuberculosis Resistance Mutations
Assay detects mutations associated with resistance to isoniazid, fluoroquinolones, aminoglycosides (Source: Pulmonary Medicine News - Doctors Lounge)
Source: Pulmonary Medicine News - Doctors Lounge - September 15, 2017 Category: Respiratory Medicine Tags: Infections, Internal Medicine, Pathology, Pulmonology, Journal, Source Type: news

Viral hepatitis kills 1.34 million worldwide
Viral hepatitis kills more people than HIV, malaria or tuberculosis, a new study found. It's one of the top ten causes of death in the world. The WHO has a plan to stop it by 2030, but efforts are lagging. (Source: the Mail online | Health)
Source: the Mail online | Health - September 14, 2017 Category: Consumer Health News Source Type: news

Post-Tuberculous Fibrosing Mediastinitis Post-Tuberculous Fibrosing Mediastinitis
This rare case provides insight into the link between tuberculosis and fibrosing mediastinitis, and discusses diagnostic and treatment strategies.BMJ Open Respiratory Research (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - September 13, 2017 Category: Consumer Health News Tags: Pulmonary Medicine Journal Article Source Type: news

This Girl Tr òn: The Forgotten Subject of Vietnam War Photographer Larry Burrows
Larry Burrows was a seasoned veteran of the Vietnam War when, in early 1968, he met 12-year-old Nguyễn Thị Tròn. Operating out of Saigon, the southern Republic of Vietnam’s capital, the photographer had been covering the conflict for LIFE magazine since 1962. He shadowed American troops, documenting ferocious firefights, surviving hours in the air with helicopter-gunship crews, and freeze-framing harrowing moments of bravery and despair, exhaustion, and appalling violence in combat zones. Though much of his best work had been shot in the thick of the action, he had come to be haunted by the trauma visited ...
Source: TIME.com: Top Science and Health Stories - September 13, 2017 Category: Consumer Health News Authors: Gary Jones/ Suối Đá Tags: Uncategorized Larry Burrows LIFE Magazine photography Vietnam Vietnam War Source Type: news

Liberia: Global Fund Delegation Meets Health Authorities
[NEWS] A Global Fund delegation that is visiting Liberia to support efforts in the fight against AIDS, Tuberculosis and Malaria (GFATM) has held talks with Health Minister, Bernice T. Dahn and other stakeholders in the health sector. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - September 12, 2017 Category: African Health Source Type: news

Huge increase in badger culling will see up to 33,500 animals shot
Ministers say culls are vital for cutting TB infections in cattle but scientists say there is little evidence to support the policyUp to 33,500 badgers will be shot this autumn in an attempt to control tuberculosis in cattle, a huge rise from the10,000 killed in 2016.Thegovernment has announced that 11 new badger cull areas have been licensed, adding to the 10 already in place. Devon now has six badger culls under way, with Somerset and Wiltshire having three each, with others in Cheshire, Cornwall, Dorset, Gloucestershire and Herefordshire.Continue reading... (Source: Guardian Unlimited Science)
Source: Guardian Unlimited Science - September 11, 2017 Category: Science Authors: Damian Carrington Environment editor Tags: Badgers Farming Wildlife UK news Animals Environment Science Veterinary medicine Agriculture Source Type: news

What role do genome variations play in tuberculosis?
In this study, the authors conducted an integrative analysis of human and pathogen genome variations in tuberculosis. The study is published in Springer Nature's Journal of Human Genetics. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - September 7, 2017 Category: Infectious Diseases Source Type: news

Global Health: Lasting Merit Found in a Tuberculosis Vaccine Invented a Century Ago
BCG vaccine, used in many countries, protects for nearly twice as long as previously thought, scientists find. (Source: NYT Health)
Source: NYT Health - September 1, 2017 Category: Consumer Health News Authors: DONALD G. McNEIL Jr. Tags: Vaccination and Immunization Tuberculosis International Journal of Epidemiology Source Type: news

Angola: Namibe - TB Kills More Than 90 People in First Half of 2017
[ANGOP] Mo çâmedes -Ninety-one people died in the first half of 2017 in south-west Namibe province, victim of tuberculosis. (Source: AllAfrica News: Tuberculosis)
Source: AllAfrica News: Tuberculosis - August 31, 2017 Category: Infectious Diseases Source Type: news

TB vaccine BCG effective for twice as long as previously thought – study
Benefits of world ’s only vaccine against tuberculosis were underestimated as new findings reveal it protects against the disease for at least 20 yearsThe BCG, an old vaccine but the only one against tuberculosis, is more effective than was thought, offering protection for at least 20 years, a new study shows.BCG vaccination used to be routine in all secondary schools in the UK for young teenagers, but in recent years it has been given only to those at risk, such as children living in inner-city areas with relatively high TB rates.Continue reading... (Source: Guardian Unlimited Science)
Source: Guardian Unlimited Science - August 31, 2017 Category: Science Authors: Sarah Boseley Health editor Tags: Medical research Tuberculosis Health Society Science UK news Source Type: news

BCG jab may protect against TB for nearly twice as long as previously thought
(London School of Hygiene& Tropical Medicine) The world's only licensed tuberculosis (TB) vaccine could offer protection against the disease for nearly twice as long as previously thought, according to new research published in the International Journal of Epidemiology. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - August 31, 2017 Category: International Medicine & Public Health Source Type: news

Tuberculosis today
(Source: ScienceNOW)
Source: ScienceNOW - August 31, 2017 Category: Science Authors: Bynum, H. Tags: Medicine, Diseases books Source Type: news

Belarus: “My doctors told me, ‘This is the only chance’”
Field newsBelarus: “My doctors told me, ‘This is the only chance’”August 30, 2017Yury*, 38, is celebrating a moment he thought would never arrive: he has been cured of extensively drug-resistanttuberculosis (XDR-TB). This moment is also a milestone for Doctors Without Borders/M édecins Sans Frontières (MSF): Yury is the first patient to complete MSF’s tuberculosis treatment program inBelarus, run in close cooperation with the Ministry of Health. (Source: MSF News)
Source: MSF News - August 30, 2017 Category: International Medicine & Public Health Authors: Clinton Krute Source Type: news

Anti-inflammatory drug may help prevent heart attacks
Conclusion This well-conducted study shows promising signs that canakinumab may reduce the risk of future heart attacks and other cardiovascular events in people who've had them in the past. But before any changes are made to the current licensing of this drug, further research is needed to confirm the beneficial effects and the optimal dose. Most importantly, researchers will need to focus on the observation that the drug lowered white blood cell counts and increased the risk of fatal infection. They estimated around 1 in every 300 people taking canakinumab would die of a fatal infection. This number, while low, is sti...
Source: NHS News Feed - August 30, 2017 Category: Consumer Health News Tags: Heart/lungs Source Type: news

Ethiopia: How Effective National Research, Innovation to End TB By 2035?
[Ethiopian Herald] Ethiopia has made a momentous stride in TB research and innovation towards curbing several impediments and emergence of new strains of multi-drug resistant TB (MDR-TB) . However, a large number of fellow citizens have been yet exposed to the high risk of contracting TB. (Source: AllAfrica News: Tuberculosis)
Source: AllAfrica News: Tuberculosis - August 30, 2017 Category: Infectious Diseases Source Type: news

Prediagnosis ED Presentations in Patients With Active TB Prediagnosis ED Presentations in Patients With Active TB
Gain a better understanding of the risk factors and symptoms that may assist in the diagnosis of tuberculosis in the ED.BMJ Open Respiratory Research (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - August 30, 2017 Category: Consumer Health News Tags: Pulmonary Medicine Journal Article Source Type: news

Antibacterial combination could fight drug-resistant tuberculosis
(American Association for the Advancement of Science) Pairing the antibiotic ceftazidime with the enzyme inhibitor avibactam may be an effective treatment for drug-resistant tuberculosis, a new study reports. This antibacterial drug combination -- already in clinical use for Gram-negative bacterial infections -- could aid in stemming the growing global drug-resistant tuberculosis crisis. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - August 30, 2017 Category: Infectious Diseases Source Type: news

TB Infection Patient Educational Materials: Tip Sheet for Providers
The Massachusetts Department of Public Health (MDPH) has created new informational materials for patients at risk for latent tuberculosis infection. These materials aim to teach patients what TB infection is and motivate them to start and complete treatment if diagnosed. (Source: PHPartners.org)
Source: PHPartners.org - August 25, 2017 Category: International Medicine & Public Health Source Type: news

24 cases of tuberculosis identified at a Texas high school
Ten more cases of tuberculosis have been diagnosed at George Bush High School (pictured) in Fort Bend County, Texas, which is near Houston, bringing the total number of cases to 24. (Source: the Mail online | Health)
Source: the Mail online | Health - August 24, 2017 Category: Consumer Health News Source Type: news

Namibia: Educational Movie On TB Screens At Waiting Rooms
[New Era] Windhoek -In an effort to spread the message on tuberculosis to the broader public the Ministry of Health and Social Services, through district tuberculosis (TB) and leprosy coordinators, is screening the Lucky Specials feature film at waiting rooms of health facilities countrywide. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - August 24, 2017 Category: African Health Source Type: news

Otsuka and Mylan Announce License Agreement to Commercialize Delamanid (Deltyba(TM)) for Multidrug-Resistant Tuberculosis (MDR-TB) in High-Burden Countries
TOKYO, HERTFORDSHIRE, England and PITTSBURGH, Aug. 24, 2017 -- (Healthcare Sales & Marketing Network) -- Otsuka Pharmaceutical Co. Ltd. (Otsuka) and Mylan N.V. (NASDAQ, TASE: MYL) have entered into a license agreement between their respective subsidiaries... Biopharmaceuticals, Licensing Mylan, Otsuka Pharmaceutical, Delamanid, Deltyba (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - August 24, 2017 Category: Pharmaceuticals Source Type: news

IDRI to continue development of inhalable TB drug candidate
(Infectious Disease Research Institute) IDRI (Infectious Disease Research Institute), on behalf of the Lilly TB Drug Discovery Initiative, announces it has entered into an agreement with Zhejiang Hisun Pharmaceutical Co., Ltd., a China-based leading biopharmaceutical company, to continue development of inhalable CPZEN-45, a tuberculosis (TB) drug candidate that could potentially treat the growing problem of antibiotic-resistant TB. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - August 24, 2017 Category: International Medicine & Public Health Source Type: news

Scientists discover how tuberculosis hijacks the immune system
(Trinity College Dublin) Scientists have unlocked a key element in understanding how human lungs fight tuberculosis (TB). They hope their research findings, which were published today in the international peer reviewed journal Immunity, will help pave the way towards new treatment approaches for TB, particularly in an era of increasing antibiotic resistance to TB. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - August 24, 2017 Category: Infectious Diseases Source Type: news

Angola: Bie - Over 1000 New Tuberculosis Cases Recorded
[ANGOP] Cuito -At least 120,000 new tuberculosis cases were recorded in the central Bie Province by the local health authorities, in the first semester of the present year, a figure that represents 112 cases more in comparison to the previous semester. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - August 23, 2017 Category: African Health Source Type: news

Study finds link between malnutrition, alcoholism and tuberculosis in India
(Boston University School of Medicine) A new study reveals a striking link between malnutrition, heavy alcohol use and tuberculosis in southern India. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - August 23, 2017 Category: Infectious Diseases Source Type: news

Cochrane Africa: A network of healthcare decision making launches across sub-Saharan Africa
Cochrane is delighted to announce the official launch ofCochrane Africa;  a network with a vision to increase the use of best evidence to inform healthcare decision making across the sub-Saharan African continent.The Africa Network consists of regional centres including its co-ordinating centre atCochrane South Africa, South African Medical Research Council, and the establishment of hubs at University of Calabar, Teaching Hospital, Nigeria, Stellenbosch University, South Africa and Yaound é University, Cameroon.Cochrane Africa is part of the global, independent Cochrane network of researchers, professionals, pa...
Source: Cochrane News and Events - August 22, 2017 Category: Information Technology Authors: Muriah Umoquit Source Type: news

Texas Biomed and UT Health Houston to team on $4.4M tuberculosis vaccine study
Researchers from San Antonio and the Bayou City are working to create an improved vaccine to fight the deadly disease. (Source: bizjournals.com Health Care:Physician Practices headlines)
Source: bizjournals.com Health Care:Physician Practices headlines - August 22, 2017 Category: American Health Authors: W. Scott Bailey Source Type: news

Ghana: Drug Resistant Tuberculosis a Major Concern in Ghana
[Deutsche Welle] Ghanaian experts are concerned about the rising number of tuberculosis. The Ghana Health Service said 14,632 people were diagnosed with TB and put on treatment. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - August 22, 2017 Category: African Health Source Type: news

Solid Organ Transplant-Transmitted TB Linked to an Outbreak Solid Organ Transplant-Transmitted TB Linked to an Outbreak
A rare tuberculosis genotype provided the clue to track down the origin of this TB outbreak, which was traced to an unusual source.Morbidity & Mortality Weekly Report (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - August 22, 2017 Category: Consumer Health News Tags: Infectious Diseases Journal Article Source Type: news

Texas Biomed and UT Health Houston to team on $4.4M tuberculosis vaccine study
Researchers from San Antonio and the Bayou City are working to create an improved vaccine to fight the deadly disease. (Source: bizjournals.com Health Care:Pharmaceuticals headlines)
Source: bizjournals.com Health Care:Pharmaceuticals headlines - August 21, 2017 Category: Pharmaceuticals Authors: W. Scott Bailey Source Type: news

Tuberculosis drug may work better than others in its class
(PLOS) Treatment of tuberculosis involves a combination of several drugs, sometimes including drugs from a class known as fluoroquinolones. Using computer simulations, scientists have shown that the fluoroquinolone known as moxifloxacin may be superior to two other commonly used fluoroquinolones, according to a new paper in PLOS Computational Biology. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - August 17, 2017 Category: Infectious Diseases Source Type: news

Johnson & Johnson and CSIR-IMTECH partner to discover new tuberculosis treatments
Johnson& Johnson ’s India-based business has signed a memorandum of understanding (MoU) with the Institute of Microbial Technology (IMTECH) to discover and develop new treatments for tuberculosis (TB). (Source: Pharmaceutical Technology)
Source: Pharmaceutical Technology - August 16, 2017 Category: Pharmaceuticals Source Type: news