Cytokine interference in infection
NIH Director's Wednesday Afternoon Lecture Series Dr. O'Garra's laboratory studies cells and molecules that control our immune systems to understand how they respond to infections and influence the outcomes and what goes wrong when infections damage healthy cells. For example, some infected individuals are protected while others go on to progress to disease such as tuberculosis (TB), which is caused by infection with Mycobacterium tuberculosis (M. tuberculosis). TB is a major cause of morbidity and mortality worldwide and efforts to control this disease are hampered by difficulties with diagnosis, prevention, and treatment...
Source: Videocast - All Events - June 10, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video

NIH Director's Wednesday Afternoon Lecture Series
Dr. O'Garra studies the signals that control our immune systems, to understand how they respond to diseases such as tuberculosis and what goes wrong when they damage healthy cells.For more information go tohttps://oir.nih.gov/wals/2018-2019Air date: 6/12/2019 3:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - April 29, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video

Microbial networking ( … it ’ s like Tinder for bugs)
NIH Director's Wednesday Afternoon Lecture Series Annual Rolla E. Dyer Lecture Few microbes (viruses, bacteria, fungi) live in isolation or exclusively with members of their own kingdom or domain. Affinities or aversions among microbial members influence the community structure, but these interactions can be reorganized with the arrival of disruptors. In respiratory infections, for example, infectious agents — be they viral or bacterial — are entering an environment within the host where they can impact existing ecological relationships among local residents. Disrupting these " social " networks has e...
Source: Videocast - All Events - February 4, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video

Demystifying Medicine 2019 - Tuberculosis: The Great White Plague Keeps Coming Back
The Demystifying Medicine Lecture Series is designed to help bridge the gap between advances in biology and their applications to major human diseases. The lectures include presentations of patients, pathology, diagnosis, and therapy in the context of major diseases and current research. All clinicians, trainees including fellows, medical students, Ph.D. students, and other healthcare and research professionals are welcome to attend.For more information go tohttps://demystifyingmedicine.od.nih.govAir date: 1/22/2019 4:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - January 3, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video

Why the Immune System Needs Us
NIH Director's Wednesday Afternoon Lecture Series To better understand and assist the immune system, my lab focuses on M. tuberculosis (Mtb), the leading cause of death from an infectious disease. Mtb has evolved to exploit human immunity, about which it must have much to teach us. Mtb can both elicit and withstand an immune response strong enough to liquefy lung and send forth infectious droplets that spread the disease. We study the biology of Mtb in the non-replicating states imposed by the sub-sterilizing host immune response and look for ways to overcome the phenotypic resistance to antibiotics that results.For more i...
Source: Videocast - All Events - May 11, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video

Bending the Arc: Film Screening and Discussion
NIH is hosting a screening of " Bending the Arc " that will be followed by a conversation between NIH Director Dr. Francis Collins and Dr. Jim Yong Kim, President of the World Bank Group. The film illustrates how Dr. Kim, doctor and humanitarian Paul Farmer, activist Ophelia Dahl, and local communities delivered world-class care for complicated diseases such as multidrug resistant tuberculosis and HIV, in the most impoverished of settings in Haiti.Air date: 3/12/2018 2:30:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - March 9, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video

Pathogen manipulation of antigen-specific T cell responses
Immunology Interest Group Seminar Series Although protective immunity to intracellular pathogens depends on T cell responses, most studies focus on events related to T cell priming and differentiation in secondary lymphoid tissues. However, effector T cells must act at sites of infection, generally in non-lymphoid tissues, to control pathogen growth and limit tissue damage. Tuberculosis, in addition to being a major problem of global health, is a chronic infection characterized by induction of apparently-appropriate T cell responses in which T cells are routinely unable to clear the pathogen (Mycobacterium tuberculosis). T...
Source: Videocast - All Events - January 3, 2017 Category: Journals (General) Tags: Upcoming Events Source Type: video

The Zebrafish Guide to Tuberculosis
Presented by: Lalita Ramakrishnan, M.D., Ph.D., University of CambridgeCategory: WALS - Wednesday Afternoon LecturesAired date: 10/07/2015 (Source: Videocast - All Events)
Source: Videocast - All Events - October 8, 2015 Category: Journals (General) Tags: Past Events Source Type: video

The Zebrafish Guide to Tuberculosis
We have developed the zebrafish as a surrogate model to study human tuberculosis. The optical transparency combined with the genetic tractability of this model have proved to be powerful and have allowed us to make surprising discoveries about tuberculosis pathogenesis, immunity, and drug tolerance that suggest completely new approaches to treatment. These discoveries and their application to human tuberculosis treatment will be discussed.For more information go to https://oir.nih.gov/walsAir date: 10/7/2015 3:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - October 6, 2015 Category: Journals (General) Tags: Upcoming Events Source Type: video

Heterogeneity of Tuberculosis
Presented by: JoAnne FlynnCategory: ImmunologyAired date: 03/25/2015 (Source: Videocast - All Events)
Source: Videocast - All Events - March 30, 2015 Category: Journals (General) Tags: Past Events Source Type: video

Heterogeneity of Tuberculosis
Immunology Interest Group Dr. JoAnne Flynn received her PhD from the University of California, Berkeley, and after completing her post-doctoral fellowships at Scripps and the Albert Einstein College of Medicine, JoAnne joined the faculty at the University of Pittsburgh in 1994. JoAnne’s primary research is focused on studying the host-pathogen interaction. Her laboratory investigates the immune mechanisms that are required for protection against Mycobacterium tuberculosis, the causative agent of tuberculosis (TB). One third of the world is infected with Mycobacterium tuberculosis, yet only 10% will develop clinical...
Source: Videocast - All Events - March 19, 2015 Category: Journals (General) Tags: Upcoming Events Source Type: video

Demystifying Medicine 2015 - Tuberculosis: Return of the White Plague
Presented by: Clifton Barry, Ph.D., NIAID, NIH and Ray Chen, M.D., NIAID, NIHCategory: Demystifying MedicineAired date: 02/03/2015 (Source: Videocast - All Events)
Source: Videocast - All Events - February 4, 2015 Category: Journals (General) Tags: Past Events Source Type: video

Demystifying Medicine 2015 - Tuberculosis: Return of the White Plague
The 2015 Demystifying Medicine Series, which is jointly sponsored by FAES and NIH, will begin January 6th and includes the presentation of patients, pathology, diagnosis and therapy in the context of major disease problems and current research. Primarily directed toward Ph.D. students, clinicians and program managers, the course is designed to help bridge the gap between advances in biology and their application to major human diseases. Each session includes clinical and basic science components presented by NIH staff and invitees. All students, fellows and staff are welcome, as well.For more information go to http://demys...
Source: Videocast - All Events - January 9, 2015 Category: Journals (General) Tags: Upcoming Events Source Type: video

Envisioning The End of AIDS: Challenges and Prospects
LaMontagne Lecture Considerable progress has been made in the global fight against HIV/AIDS, but a sustained, comprehensive approach is needed to end to the pandemic, according to Dr. Salim S. Abdool Karim, a leading South African clinical infectious diseases epidemiologist and HIV prevention and treatment researcher. Abdool Karim will discuss how the global community is positioned to strengthen and reinvigorate the AIDS response during the 2014 John Ring LaMontagne Memorial Lecture titled, “Envisioning ‘The End of AIDS’: Challenges and Prospects.” Abdool Karim is president of the South African...
Source: Videocast - All Events - February 12, 2014 Category: Journals (General) Tags: Upcoming Events Source Type: video

TB: It Takes More than a Village to Raise a Remedy
8th Annual Philip S. Chen, Jr., Ph.D. Distinguished Lecture on Innovation and Technology Transfer Dr. Clifton E. Barry received his Ph.D. degree in organic and bioorganic chemistry in 1989 from Cornell University, and then was a postdoctoral fellow in the department of chemistry at the Johns Hopkins University. In 1991, he joined the NIH intramural research program as an investigator at the Rocky Mountain Laboratories, studying DNA-protein interactions during chlamydial development. In 1993 he established the Mycobacterial Research Unit that initially studied mycolic acid biosynthesis in Mycobacterium tuberculosis. In 199...
Source: Videocast - All Events - November 14, 2013 Category: Journals (General) Tags: Upcoming Events Source Type: video

Bill Gates to Deliver 2013 David E. Barmes Global Health Lecture: Why the Future Needs Biomedical Innovation
The David E. Barmes Global Health Lecture is the single most important named lecture at NIH on global health. This year's speaker is Bill Gates. The lecture series honors the late David Edward Barmes, special expert for international health at NIDCR. The lecture was established in 2001 to honor his lifelong dedication to research aimed at improving health for people in low-income countries. About Bill Gates: Known for his philanthropy, Mr. Gates advocates for research and innovation to help people live healthy and productive lives. He also is an outspoken supporter of federal investment in basic scientific research. I...
Source: Videocast - All Events - November 6, 2013 Category: Journals (General) Tags: Upcoming Events Source Type: video

2013 David E. Barmes Global Health Lecture
The David E. Barmes Global Health Lecture is the single most important named lecture at NIH on global health. This year's speaker is Bill Gates. The lecture series honors the late David Edward Barmes, special expert for international health at NIDCR. The lecture was established in 2001 to honor his lifelong dedication to research aimed at improving health for people in low-income countries. About Bill Gates: Known for his philanthropy, Mr. Gates advocates for research and innovation to help people live healthy and productive lives. He also is an outspoken supporter of federal investment in basic scientific research. I...
Source: Videocast - All Events - September 24, 2013 Category: Journals (General) Tags: Upcoming Events Source Type: video