The Magnitude of MTB and Rifampicin Resistance MTB Using Xpert-MTB/RIF Assay Among Tuberculosis Suspected Patients in Gedeo Zone, Southern Ethiopia
(Source: Infection and Drug Resistance)
Source: Infection and Drug Resistance - September 24, 2021 Category: Infectious Diseases Tags: Infection and Drug Resistance Source Type: research

Prevalence of latent tuberculosis infection and its risk factors in Japanese hemodialysis patients
ConclusionsThe prevalence of LTBI is high in Japanese HD patients, especially from the age of 60  years. Older age was a significant risk factor for LTBI, with prediction difficult using other clinical data. Extended HD may mask IGRA results. Therefore, aggressive screening for LTBI is advised in all HD patients regardless of hospital region or type, especially in patients over 60 years of ag e or newly commencing HD. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - September 24, 2021 Category: Urology & Nephrology Source Type: research

IJERPH, Vol. 18, Pages 10042: A Saudi Arabian Public Health Perspective of Tuberculosis
llo Iriti Tuberculosis is a global health challenge due to its spreading potential. The Kingdom of Saudi Arabia (KSA) faces a challenge in the spread of tuberculosis from migrant workers, but the foremost threat is the huge number of pilgrims who travel to visit sacred sites of the Islamic world located in the holy cities of Makkah and Al Madina. Pilgrims visit throughout the year but especially in the months of Ramadan and Zul-Hijah. The rise of resistance in Mycobacterium tuberculosis is an established global phenomenon that makes such large congregations likely hotspots in the dissemination and spread of disease at ...
Source: International Journal of Environmental Research and Public Health - September 24, 2021 Category: Environmental Health Authors: Abdullah A. Saati Muhammad Khurram Hani Faidah Abdul Haseeb Marcello Iriti Tags: Review Source Type: research

The Transcription Factor Rv1453 Regulates the Expression of qor and Confers Resistant to Clofazimine in Mycobacterium tuberculosis
(Source: Infection and Drug Resistance)
Source: Infection and Drug Resistance - September 23, 2021 Category: Infectious Diseases Tags: Infection and Drug Resistance Source Type: research

Hepatitis B (HBV) reactivation in patients receiving biologic therapy for chronic inflammatory diseases in clinical practice
This study aimed to update data on HBV prevalence and reactivation in patients receiving biologic therapy for either chronic rheumatic diseases or IBD, and to describe their management in clinical practice.MATERIALS AND METHODS: This study was performed in 6 Italian centers (3 Rheumatology Units and 3 Gastroenterology Units). Clinical, biochemical and virological data, as well as follow up information, were recorded and analyzed.RESULTS: 984 patients were considered, including 817 with rheumatic disease and 167 with IBD. A total of 43 showed HBV infection (38 OBI and 5 carriers) accounting for a prevalence of 4%. Among OBI...
Source: Ann Ist Super Sanita - September 23, 2021 Category: Biomedical Science Authors: Lorenzo Ridola Angelo Zullo Bruno Lagan à Roberto Lorenzetti Alberto Migliore Roberta Pica Andrea Picchianti Diamanti Gianfranco Gigliucci Palma Scolieri Vincenzo Bruzzese Source Type: research

Synthesis of a Tridecasaccharide Lipooligosaccharide Antigen from the Opportunistic Pathogen Mycobacterium kansasii
This report describes the first syntheses related to M. kansasii LOSs and 2 is the most complex mycobacterial LOS glycan to be synthesized to date when considering size and number of unique monosaccharides and glycosidic linkages. These studies not only provide a roadmap for the preparation of additional members of this family of glycans, but also provides a valuable probe for use in structure-activity relationship investigations.PMID:34553821 | DOI:10.1002/anie.202111549 (Source: Angewandte Chemie)
Source: Angewandte Chemie - September 23, 2021 Category: Chemistry Authors: Todd Lowary Ke Shen Bing Bai Yu-Hsuan Liu Source Type: research

Hepatitis B (HBV) reactivation in patients receiving biologic therapy for chronic inflammatory diseases in clinical practice
This study aimed to update data on HBV prevalence and reactivation in patients receiving biologic therapy for either chronic rheumatic diseases or IBD, and to describe their management in clinical practice.MATERIALS AND METHODS: This study was performed in 6 Italian centers (3 Rheumatology Units and 3 Gastroenterology Units). Clinical, biochemical and virological data, as well as follow up information, were recorded and analyzed.RESULTS: 984 patients were considered, including 817 with rheumatic disease and 167 with IBD. A total of 43 showed HBV infection (38 OBI and 5 carriers) accounting for a prevalence of 4%. Among OBI...
Source: Annali dell Istituto Superiore di Sanita - September 23, 2021 Category: General Medicine Authors: Lorenzo Ridola Angelo Zullo Bruno Lagan à Roberto Lorenzetti Alberto Migliore Roberta Pica Andrea Picchianti Diamanti Gianfranco Gigliucci Palma Scolieri Vincenzo Bruzzese Source Type: research

A Bumpy Ride of Mycobacterial Phagosome Maturation: Roleplay of Coronin1 Through Cofilin1 and cAMP
Phagosome-lysosome fusion in innate immune cells like macrophages and neutrophils marshal an essential role in eliminating intracellular microorganisms. In microbe-challenged macrophages, phagosome-lysosome fusion occurs 4 to 6 h after the phagocytic uptake of the microbe. However, live pathogenic mycobacteria hinder the transfer of phagosomes to lysosomes, up to 20 h post-phagocytic uptake. This period is required to evade pro-inflammatory response and upregulate the acid-stress tolerant proteins. The exact sequence of events through which mycobacteria retards phagolysosome formation remains an enigma. The macro...
Source: Frontiers in Immunology - September 23, 2021 Category: Allergy & Immunology Source Type: research

IJERPH, Vol. 18, Pages 9991: Improving Treatment Adherence with Integrated Patient Management for TB Patients in Morocco
This study aims to examine the delivery model of TB management and the outcomes of an integrated patient management system that uses a patient-centered and community-based approach, along with mobile health technology. A total of 3605 TB patients were enrolled in this program in Morocco’s five prefectures (Rabat, Salé, Kénitra, Khemisset, Skhirat–Témara) from January 2018 to December 2019. Patients were managed based on demographic characteristics, socioeconomic status, areas (rural or urban), health literacy levels, and distance to primary health centers. Our mobile health intervention &ld...
Source: International Journal of Environmental Research and Public Health - September 23, 2021 Category: Environmental Health Authors: Seup Park Narae Moon Byungkwon Oh Miyeon Park Kilho Kang Ilham Sentissi Sung-Heui Bae Tags: Article Source Type: research

Lack of latent tuberculosis screening and delay in Anti-Retroviral Therapy initiation in HIV-TB co-infection: A 11-year study in an intermediate TB-burden country
The World Health Organisation estimates 10 million new patients with active tuberculosis (TB) disease is diagnosed globally every year, of whom a considerable proportion are among people living with HIV (WHO, 2020a). People living with HIV are more susceptible to active TB disease as HIV infection increases the risks of developing TB by 16-27 times compared to those without HIV (WHO, 2021b). TB remains a leading cause of death in the HIV population worldwide even though TB is both preventable and treatable. (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - September 23, 2021 Category: Infectious Diseases Authors: Vannesa Yue May Teng, Yan Ting Chua, Eunice En Ni Lai, Shilpa Mukherjee, Jessica Michaels, Chen Seong Wong, Liang Shen, Yee Sin Leo, Barnaby Young, Sophia Archuleta, Catherine W.M. Ong Tags: Original Article Source Type: research

Duration and determinants of delayed tuberculosis diagnosis and treatment in high-burden countries: a mixed-methods systematic review and meta-analysis
Thirty countries with the highest tuberculosis (TB) burden bear 87% of the world ’s TB cases. Delayed diagnosis and treatment are detrimental to TB prognosis and sustain TB transmission in the community, making... (Source: Respiratory Research)
Source: Respiratory Research - September 23, 2021 Category: Respiratory Medicine Authors: Alvin Kuo Jing Teo, Shweta R. Singh, Kiesha Prem, Li Yang Hsu and Siyan Yi Tags: Research Source Type: research

Fucoidan-Coated Liposomes: A Target System to Deliver the Antimicrobial Drug Usnic Acid to Macrophages Infected with Mycobacterium tuberculosis
(Source: Journal of Biomedical Nanotechnology)
Source: Journal of Biomedical Nanotechnology - September 22, 2021 Category: Nanotechnology Authors: Lima Salviano, Taciana dos Santos Macedo, Daniel Charles de Siqueira Ferraz Carvalho, Rafaela Pereira, Marcela Ara újo de Arruda Barbosa, Vanessa Santos dos Santos Aguiar, Jaciana Souto, Fabr ício Oliveira Carvalho da Silva, Maria da Paz Lapa Montenegro Tags: research-article Source Type: research

GSE179966 Next Generation Sequencing Facilitates Quantitative Analysis of Zinc treated Wild-Type or CmtR-deleted strains of Mycobacterium bovis BCG Transcriptomes
Contributors : Zhengguo He ; Liu ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Mycobacterium tuberculosis variant bovis BCGThe goal of this study aims to quantitatively compare the gene expression difference in wild-type or cmtR-deleted strains of Mycobacterium bovis BCG with and without excess zinc treatment at the transcriptome level and find the underlying mechanism how could excess zinc inhibit mycobacterial growth and its relation with transcription factor CmtR. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - September 22, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mycobacterium tuberculosis variant bovis BCG Source Type: research

GSE176139 RNAseq of rabbit lungs infected with Mycobacterium tuberculosis as single cells or aggregates
Contributor : Selvakumar SubbianSeries Type : Expression profiling by high throughput sequencingOrganism : Oryctolagus cuniculusThe virulence of Mycobacterium tuberculosis (Mtb), either as mostly aggregates or single cells (Mtb-SC), was compared using a rabbit model of pulmonary infection. Our hypothesis is that aggregation contributes to enhanced virulence of Mtb. Rabbit lung transcriptome was analyzed by RNAseq to identify differentially regulated gene networks and pathways between Mtb-AG and Mtb-SC infection of rabbit lungs soon after seeding of the bacteria (24 hours post-inoculation). (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - September 22, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Oryctolagus cuniculus Source Type: research

A Mycobacterium tuberculosis Specific IgG3 Signature of Recurrent Tuberculosis
South Africa has the highest prevalence of HIV and tuberculosis (TB) co-infection globally. Recurrent TB, caused by relapse or reinfection, makes up the majority of TB cases in South Africa, and HIV infected individuals have a greater likelihood of developing recurrent TB. Given that TB remains a leading cause of death for HIV infected individuals, and correlates of TB recurrence protection/risk have yet to be defined, here we sought to understand the antibody associated mechanisms of recurrent TB by investigating the humoral response in a longitudinal cohort of HIV co-infected individuals previously treated for TB with an...
Source: Frontiers in Immunology - September 22, 2021 Category: Allergy & Immunology Source Type: research

Extensively drug-resistant tuberculosis treated with bedaquiline: A case report in the particularly vulnerable tribal group of Madhya Pradesh, India
Prashant Mishra, R Sharma, R Yadav, Gaurav Bansal, VG Rao, Jyothi BhatIndian Journal of Public Health 2021 65(3):318-320 The management of drug-resistant (DR) tuberculosis (TB) remains a challenge particularly in remote rural areas of the country. Although the treatment with wholly oral drug regimens, including bedaquiline (BDQ) and delamanid, is rolled out under the National TB Elimination Program, little is known about its coverage and the effectiveness in hard-to-reach tribal areas. The present report describes the early identification and successful management, through team effort, of a case of extensively DR TB belon...
Source: Indian Journal of Public Health - September 22, 2021 Category: International Medicine & Public Health Authors: Prashant Mishra R Sharma R Yadav Gaurav Bansal VG Rao Jyothi Bhat Source Type: research

High resolution melting assay as a reliable method for diagnosing drug-resistant TB cases: a systematic review and meta-analysis
Tuberculosis (TB) is one of the most contagious infectious diseases worldwide. Currently, drug-resistant Mycobacterium tuberculosis (Mtb) isolates are considered as one of the main challenges in the global TB con... (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - September 22, 2021 Category: Infectious Diseases Authors: Masoud Keikha and Mohsen Karbalaei Tags: Research Source Type: research

Testing for latent tuberculosis before starting patients on immune checkpoint inhibitors
Chirag DharIndian Journal of Cancer 2021 58(3):469-470 (Source: Indian Journal of Cancer)
Source: Indian Journal of Cancer - September 22, 2021 Category: Cancer & Oncology Authors: Chirag Dhar Source Type: research

The influence of the gut microbiome on BCG-induced trained immunity
The bacillus Calmette-Gu érin (BCG) vaccine protects against tuberculosis and heterologous infections but elicits high inter-individual variation in specific and nonspecific, or trained, immune responses. While... (Source: Genome Biology)
Source: Genome Biology - September 22, 2021 Category: Genetics & Stem Cells Authors: Martin Stra žar, Vera P. Mourits, Valerie A. C. M. Koeken, L. Charlotte J. de Bree, Simone J. C. F. M. Moorlag, Leo A. B. Joosten, Reinout van Crevel, Hera Vlamakis, Mihai G. Netea and Ramnik J. Xavier Tags: Research Source Type: research

Non-IFNγ Whole Blood Cytokine Responses to Mycobacterium tuberculosis Antigens in HIV-exposed Infants
Conclusions: We detected non-IFNg Mtb antigen-specific T-cell responses in 14-month HEU infants. Non-IFNg cytokines may be more sensitive than IFNg in detecting infant Mtb infection. IPT during the first year of life was not associated with Mtb infection measured by IFNg, IL2, IP10 and TNF Mtb-specific responses. (Source: The Pediatric Infectious Disease Journal)
Source: The Pediatric Infectious Disease Journal - September 21, 2021 Category: Infectious Diseases Tags: Translational Medicine Reports Source Type: research

Effect of Isoniazid Preventive Therapy on the Incidence of Tuberculosis among Seropositive Children Attending HIV/AIDS Care in Two General Hospitals, Northwest Ethiopia, 2021
This study aimed to assess the effect of isoniazid preventive therapy on the incidence of tuberculosis for seropositive children in Northwest Ethiopia. Methods. A facility-based retrospective follow-up was employed for reviewing 421 files from 1 January 2015 up to 30 December 2019. EpiData version 3.2 and Stata/14 software were used for data entry and analysis, respectively. Categorical variables at bivariable Cox regression were assessed for candidates transferred at P value
Source: Journal of Tropical Medicine - September 21, 2021 Category: Tropical Medicine Authors: Fassikaw Kebede Birhanu Kebede Tsehay Kebede Melaku Agmasu Source Type: research

Designing a therapeutic and prophylactic candidate vaccine against human papillomavirus through vaccinomics approaches
CONCLUSION: Ultimately, this study led to suggest the designed construct as a potential vaccine candidate with both prophylactic and therapeutic applications against HPV by promoting Th1, Th2, CTL, and B cell immune responses, which should be further confirmed in experimental studies.PMID:34547435 | DOI:10.1016/j.meegid.2021.105084 (Source: Infection, Genetics and Evolution)
Source: Infection, Genetics and Evolution - September 21, 2021 Category: Genetics & Stem Cells Authors: Ashkan Bagheri Navid Nezafat Mahboobeh Eslami Younes Ghasemi Manica Negahdaripour Source Type: research

A qualitative study of perspectives on access to tuberculosis health services in Xigaze, China
CONCLUSIONS: We identified barriers and facilitators to accessing services in rural communities in Xigaze from the perspective of persons impacted by TB. Challenges include complex pathways to care, travel distances, wait times and low awareness. Tuberculosis care in the region could be strengthened by ongoing culturally tailored educational campaigns to increase awareness, partnerships with TTM providers, providing comprehensive treatment subsidies and strengthening the role of family members in comprehensive TB care.PMID:34544492 | DOI:10.1186/s40249-021-00906-4 (Source: Rural Remote Health)
Source: Rural Remote Health - September 21, 2021 Category: Rural Health Authors: Victoria Haldane Zhitong Zhang Qi Ma Tingting Yin Bei Zhang Yinlong Li Qiuyu Pan Katie N Dainty Elizabeth Rea Pande Pasang Xiaolin Wei Jun Hu Source Type: research

Accounting for misclassified and unknown cause of death data in vital registration systems for estimating trends in HIV mortality
CONCLUSIONS: Correcting for miscoding and misclassification of cause of death data can enhance the utility of the data for analyzing trends in HIV mortality and tracking progress toward the Sustainable Development Goal targets.PMID:34546661 | DOI:10.1002/jia2.25791 (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - September 21, 2021 Category: Infectious Diseases Authors: Hmwe H Kyu Deepa Jahagirdar Matthew Cunningham Magdalene Walters Edmond Brewer Amanda Novotney Eve Wool Ilse Dippennar Fablina Sharara Chieh Han Shelly Balassyano Greg Bertolacci Christopher J L Murray Mohsen Naghavi Source Type: research

Effect of Isoniazid Preventive Therapy on the Incidence of Tuberculosis among Seropositive Children Attending HIV/AIDS Care in Two General Hospitals, Northwest Ethiopia, 2021
This study aimed to assess the effect of isoniazid preventive therapy on the incidence of tuberculosis for seropositive children in Northwest Ethiopia. Methods. A facility-based retrospective follow-up was employed for reviewing 421 files from 1 January 2015 up to 30 December 2019. EpiData version 3.2 and Stata/14 software were used for data entry and analysis, respectively. Categorical variables at bivariable Cox regression were assessed for candidates transferred at P value
Source: Journal of Tropical Medicine - September 21, 2021 Category: Tropical Medicine Authors: Fassikaw Kebede Birhanu Kebede Tsehay Kebede Melaku Agmasu Source Type: research

Designing a therapeutic and prophylactic candidate vaccine against human papillomavirus through vaccinomics approaches
CONCLUSION: Ultimately, this study led to suggest the designed construct as a potential vaccine candidate with both prophylactic and therapeutic applications against HPV by promoting Th1, Th2, CTL, and B cell immune responses, which should be further confirmed in experimental studies.PMID:34547435 | DOI:10.1016/j.meegid.2021.105084 (Source: Infection, Genetics and Evolution)
Source: Infection, Genetics and Evolution - September 21, 2021 Category: Genetics & Stem Cells Authors: Ashkan Bagheri Navid Nezafat Mahboobeh Eslami Younes Ghasemi Manica Negahdaripour Source Type: research

Accounting for misclassified and unknown cause of death data in vital registration systems for estimating trends in HIV mortality
CONCLUSIONS: Correcting for miscoding and misclassification of cause of death data can enhance the utility of the data for analyzing trends in HIV mortality and tracking progress toward the Sustainable Development Goal targets.PMID:34546661 | DOI:10.1002/jia2.25791 (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - September 21, 2021 Category: Infectious Diseases Authors: Hmwe H Kyu Deepa Jahagirdar Matthew Cunningham Magdalene Walters Edmond Brewer Amanda Novotney Eve Wool Ilse Dippennar Fablina Sharara Chieh Han Shelly Balassyano Greg Bertolacci Christopher J L Murray Mohsen Naghavi Source Type: research

Effect of Isoniazid Preventive Therapy on the Incidence of Tuberculosis among Seropositive Children Attending HIV/AIDS Care in Two General Hospitals, Northwest Ethiopia, 2021
This study aimed to assess the effect of isoniazid preventive therapy on the incidence of tuberculosis for seropositive children in Northwest Ethiopia. Methods. A facility-based retrospective follow-up was employed for reviewing 421 files from 1 January 2015 up to 30 December 2019. EpiData version 3.2 and Stata/14 software were used for data entry and analysis, respectively. Categorical variables at bivariable Cox regression were assessed for candidates transferred at P value
Source: Journal of Tropical Medicine - September 21, 2021 Category: Tropical Medicine Authors: Fassikaw Kebede Birhanu Kebede Tsehay Kebede Melaku Agmasu Source Type: research

IJERPH, Vol. 18, Pages 9928: Impact of Two Different Recruitment Procedures (Random versus Volunteer Selection) on the Results of Seroepidemiological Study (SARS-CoV-2)
ejda The proper recruitment of subjects for population-based epidemiological studies is critical to the external validity of the studies and, above all, to the sound and correct interpretation of the findings. Since 2020, the novel coronavirus SARS-CoV-2 pandemic has been a new factor that has been, additionally, hindering studies. Therefore, the aim of our study is to compare demographic, socio-economic, health-related characteristics and the frequency of SARS-CoV-2 infection occurrence among the randomly selected group and the group composed of volunteers. We compare two groups of participants from the cross-sectiona...
Source: International Journal of Environmental Research and Public Health - September 21, 2021 Category: Environmental Health Authors: Maksymilian Gajda Ma łgorzata Kowalska Jan Eugeniusz Zejda Tags: Article Source Type: research

Immobilization of Proteinase K for urine pretreatment to improve diagnostic accuracy of active tuberculosis
by Yosita Panraksa, Anita G. Amin, Barbara Graham, Charles S. Henry, Delphi Chatterjee The World Health Organization (WHO) calls for the development of a rapid, biomarker-based, non-sputum test capable of detecting all forms of tuberculosis (TB) at the point-of-care to enable immediate treatment initiation. Lipoarabinomannan (LAM) is the only WHO-endorsed TB biomarker that can be de tected in urine, an easily collected sample matrix. For obtaining optimal sensitivity, we and others have shown that some form of sample pretreatment is necessary to remove background from patient urine samples. A number of systems are paper-b...
Source: PLoS One - September 21, 2021 Category: Biomedical Science Authors: Yosita Panraksa Source Type: research

Tuberculosis and anemia —cause or effect?
(Source: Environmental Health and Preventive Medicine)
Source: Environmental Health and Preventive Medicine - September 21, 2021 Category: Environmental Health Source Type: research

Characterizing the molecular composition and diagnostic potential of Mycobacterium tuberculosis urinary cell-free DNA using next-generation sequencing
BACKGROUND (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - September 21, 2021 Category: Infectious Diseases Authors: Amy Oreskovic, Adam Waalkes, Elizabeth A. Holmes, Christopher A. Rosenthal, Douglas P.K. Wilson, Adrienne E. Shapiro, Paul K. Drain, Barry R. Lutz, Stephen J. Salipante Source Type: research

IJERPH, Vol. 18, Pages 9928: Impact of Two Different Recruitment Procedures (Random vs. Volunteer Selection) on the Results of Seroepidemiological Study (SARS-CoV-2)
ejda The proper recruitment of subjects for population-based epidemiological studies is critical to the external validity of the studies and, above all, to the sound and correct interpretation of the findings. Since 2020, the novel coronavirus SARS-CoV-2 pandemic has been a new factor that has been, additionally, hindering studies. Therefore, the aim of our study is to compare demographic, socio-economic, health-related characteristics and the frequency of SARS-CoV-2 infection occurrence among the randomly selected group and the group composed of volunteers. We compare two groups of participants from the cross-sectiona...
Source: International Journal of Environmental Research and Public Health - September 21, 2021 Category: Environmental Health Authors: Maksymilian Gajda Ma łgorzata Kowalska Jan Eugeniusz Zejda Tags: Article Source Type: research

Tuberculosis
(Source: Journal of Midwifery and Women's Health)
Source: Journal of Midwifery and Women's Health - September 20, 2021 Category: Midwifery Tags: Share with Women Source Type: research

Relational Dynamics of Treatment Behavior Among Individuals with Tuberculosis in High-Income Countries: A Scoping Review
(Source: Patient Preference and Adherence)
Source: Patient Preference and Adherence - September 20, 2021 Category: International Medicine & Public Health Tags: Patient Preference and Adherence Source Type: research

Imaging of Tuberculosis in Children
Tuberculosis (TB) is highly prevalent worldwide, and it affects children and adults equally, causing significant morbidity and mortality. Imaging plays a crucial role in diagnosis and management. Knowledge of imaging modalities available, imaging manifestations of both pulmonary and extrapulmonary tuberculosis, is vital for the radiologist for timely diagnosis among children with TB. (Source: Contemporary Diagnostic Radiology)
Source: Contemporary Diagnostic Radiology - September 20, 2021 Category: Radiology Tags: ARTICLE Source Type: research

Imaging of Tuberculosis in Children
No abstract available (Source: Contemporary Diagnostic Radiology)
Source: Contemporary Diagnostic Radiology - September 20, 2021 Category: Radiology Tags: CME QUIZ: VOLUME 44, NUMBER 21 Source Type: research

Combined Pulmonary Tuberculosis with Pulmonary and Pleural Cryptococcosis in a Patient Receiving Ruxolitinib Therapy
(Source: Infection and Drug Resistance)
Source: Infection and Drug Resistance - September 20, 2021 Category: Infectious Diseases Tags: Infection and Drug Resistance Source Type: research

Evaluation of latent tuberculosis infection in liver transplant recipients
CONCLUSION: According to our study, tuberculin skin test is a reliable and sensitive test for diagnosis of latent tuberculosis in liver transplant candidates. Isoniazid prophylaxis is well tolerated in patients with end stage liver diseases and liver transplant recipients.PMID:34540155 | PMC:PMC8408033 | DOI:10.18502/ijm.v13i2.5981 (Source: Iranian Journal of Microbiology)
Source: Iranian Journal of Microbiology - September 20, 2021 Category: Microbiology Authors: Zahra Ahmadinejad Maryam Mokhtaryan Arezoo Salami Monavar Talebian Hamideh Irajian Fereshteh Ghiasvand Source Type: research

Occurrence and risk factors of nontuberculous mycobacteria in tuberculosis-suspected patients in the north of Iran
CONCLUSION: Although the NTM species has a small portion in TB suspected patients, their prevalence has increased, mainly in elderly patients. Moreover, M. simiae was the most prevalent NTM species in our region. Therefore, identification of common species in each region is recommended and clinicians should pay more attention to them in each region.PMID:34540154 | PMC:PMC8408032 | DOI:10.18502/ijm.v13i2.5980 (Source: Iranian Journal of Microbiology)
Source: Iranian Journal of Microbiology - September 20, 2021 Category: Microbiology Authors: Maryam Shafipour Hesamaddin Shirzad-Aski Ezzat Allah Ghaemi Ahmad Sohrabi Masoumeh Taziki Maya Babai Kochkaksaraei Somayeh Rahimi Source Type: research

Linezolid population pharmacokinetics in South African adults with drug-resistant tuberculosis
CONCLUSION Our model characterised population pharmacokinetics of linezolid in South African patients with DR-TB and supports the 600 mg daily dose with safety monitoring.PMID:34543098 | DOI:10.1128/AAC.01381-21 (Source: Antimicrobial Agents and Chemotherapy)
Source: Antimicrobial Agents and Chemotherapy - September 20, 2021 Category: Microbiology Authors: Mahmoud Tareq Abdelwahab Sean Wasserman James C M Brust Keertan Dheda Lubbe Wiesner Neel R Gandhi Robin M Warren Frederick A Sirgel Graeme Meintjes Gary Maartens Paolo Denti Source Type: research

The QcrB inhibitors TB47 and telacebec do not potentiate the activity of clofazimine in < em > Mycobacterium abscessus < /em >
Antimicrob Agents Chemother. 2021 Sep 20:AAC0096421. doi: 10.1128/AAC.00964-21. Online ahead of print.ABSTRACTThe anti-tuberculosis drug telacebec is ineffective against Mycobacterium abscessus. A recent study suggested that TB47, a telacebec analogue, potentiated the efficacy of clofazimine against M. abscessus. Here, we report that TB47 is not only ineffective against M. abscessus in vitro, it also does not potentiate the activity of clofazimine.PMID:34543090 | DOI:10.1128/AAC.00964-21 (Source: Antimicrobial Agents and Chemotherapy)
Source: Antimicrobial Agents and Chemotherapy - September 20, 2021 Category: Microbiology Authors: Ria Sorayah Garret C Moraski Daniel Barkan Kevin Pethe Source Type: research

Study on the value of molecular biology combined with liquid MGIT culture method in clinical examination of mycobacterium tuberculosis
Am J Transl Res. 2021 Aug 15;13(8):9757-9763. eCollection 2021.ABSTRACTOBJECTIVE: To investigate the clinical value of molecular biology (xpert MTB/RIF) combined with a liquid mycobacterium culture tube (MGIT) in the clinical examination of Mycobacterium tuberculosis (MTB).METHODS: A total of 782 patients with suspected pulmonary tuberculosis who came to our hospital from February 2018 to February 2020 were selected as the research subjects. Sputum samples of all patients were taken in the morning, and BACTEC MGIT culture and xpert MTB/RIF, Lowenstein-Jenden (L-J) culture and acid fast staining microscopy were used respect...
Source: American Journal of Translational Research - September 20, 2021 Category: Research Authors: Jinyou Qi Wei Fan Source Type: research

Increased Detection of Mycobacterium tuberculosis Disease Using a Tissue-Based Laboratory-Developed Polymerase Chain Reaction Assay Compared to Standard Diagnostics
We describe the clinical performance of a laboratory-developed tissue-based MTB PCR compared with AFB culture and Xpert using a composite reference standard (CRS). Over an 8-year period, MTB PCR was performed on pulmonary, pleural, or lymph node specimens for 36 patients. Of these, 11 met criteria for confirmed/probable MTB using CRS. MTB PCR was positive in 100% (11/11), AFB cultures were positive in 73% (8/11), and Xpert in 0% (0/4). MTB PCR was negative in 25 cases of "No MTB" (100% specific). The MTB PCR assay resulted faster than positive AFB culture (mean time 4.3 versus 21.2 days). Tissue-based MTB PCR was...
Source: The American Journal of Tropical Medicine and Hygiene - September 20, 2021 Category: Tropical Medicine Authors: Natalie A Mackow Rita Abi-Raad Christopher A Keratanzas Pei Hui Maricar Malinis Marwan M Azar Source Type: research

Effect of the COVID-19 Pandemic Preparation and Response on Essential Health Services in Primary and Tertiary Healthcare Settings of Amhara Region, Ethiopia
In conclusion, the study highlights that the effect of public restrictions to mitigate the COVID-19 pandemic on essential care systems should be considered.PMID:34544048 | DOI:10.4269/ajtmh.21-0354 (Source: The American Journal of Tropical Medicine and Hygiene)
Source: The American Journal of Tropical Medicine and Hygiene - September 20, 2021 Category: Tropical Medicine Authors: Wendemagegn Enbiale Seid Getahun Abdela Meaza Seyum Dereje Bedanie Hundie Kassawmar Angaw Bogale Koku Sisay Tamirat Mulat Birhanu Feleke Muluken Azage Dabere Nigatu Henry J C de Vries Source Type: research

Meeting report: Virtual Global Forum on Tuberculosis Vaccines, 20-22 April 2021
Vaccine. 2021 Sep 15:S0264-410X(21)01154-3. doi: 10.1016/j.vaccine.2021.08.094. Online ahead of print.ABSTRACTThe Global Forum on Tuberculosis (TB) Vaccines was held virtually from 20 to 22 April 2021, marking its 20th anniversary. The Global Forum on TB Vaccines is the world's largest gathering of stakeholders striving to develop new vaccines to prevent TB. The program included more than 60 speakers in 11 scientific sessions, panel discussions, and workshops. It provided an overview of the state of the field, and an opportunity to share the latest research findings, as well as new and innovative approaches to TB vaccine r...
Source: Vaccine - September 20, 2021 Category: Allergy & Immunology Authors: Sara Suliman Puck T Pelzer Moagi Shaku Virginie Rozot Simon C Mendelsohn Source Type: research

Effect of the COVID-19 Pandemic Preparation and Response on Essential Health Services in Primary and Tertiary Healthcare Settings of Amhara Region, Ethiopia
In conclusion, the study highlights that the effect of public restrictions to mitigate the COVID-19 pandemic on essential care systems should be considered.PMID:34544048 | DOI:10.4269/ajtmh.21-0354 (Source: Am J Trop Med Hyg)
Source: Am J Trop Med Hyg - September 20, 2021 Category: Infectious Diseases Authors: Wendemagegn Enbiale Seid Getahun Abdela Meaza Seyum Dereje Bedanie Hundie Kassawmar Angaw Bogale Koku Sisay Tamirat Mulat Birhanu Feleke Muluken Azage Dabere Nigatu Henry J C de Vries Source Type: research

Increased Detection of Mycobacterium tuberculosis Disease Using a Tissue-Based Laboratory-Developed Polymerase Chain Reaction Assay Compared to Standard Diagnostics
We describe the clinical performance of a laboratory-developed tissue-based MTB PCR compared with AFB culture and Xpert using a composite reference standard (CRS). Over an 8-year period, MTB PCR was performed on pulmonary, pleural, or lymph node specimens for 36 patients. Of these, 11 met criteria for confirmed/probable MTB using CRS. MTB PCR was positive in 100% (11/11), AFB cultures were positive in 73% (8/11), and Xpert in 0% (0/4). MTB PCR was negative in 25 cases of "No MTB" (100% specific). The MTB PCR assay resulted faster than positive AFB culture (mean time 4.3 versus 21.2 days). Tissue-based MTB PCR was...
Source: Am J Trop Med Hyg - September 20, 2021 Category: Infectious Diseases Authors: Natalie A Mackow Rita Abi-Raad Christopher A Keratanzas Pei Hui Maricar Malinis Marwan M Azar Source Type: research

Latent tuberculosis infection and kidney transplantation
J Bras Nefrol. 2021 Sep 20:S0101-28002021005068301. doi: 10.1590/2175-8239-JBN-2021-E008. Online ahead of print.NO ABSTRACTPMID:34543376 | DOI:10.1590/2175-8239-JBN-2021-E008 (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - September 20, 2021 Category: Urology & Nephrology Authors: Felipe Francisco Tuon Source Type: research

Evaluation of latent tuberculosis infection in liver transplant recipients
CONCLUSION: According to our study, tuberculin skin test is a reliable and sensitive test for diagnosis of latent tuberculosis in liver transplant candidates. Isoniazid prophylaxis is well tolerated in patients with end stage liver diseases and liver transplant recipients.PMID:34540155 | PMC:PMC8408033 | DOI:10.18502/ijm.v13i2.5981 (Source: Iranian Journal of Microbiology)
Source: Iranian Journal of Microbiology - September 20, 2021 Category: Microbiology Authors: Zahra Ahmadinejad Maryam Mokhtaryan Arezoo Salami Monavar Talebian Hamideh Irajian Fereshteh Ghiasvand Source Type: research