A plasmonic fiberoptic absorbance biosensor for mannose-capped lipoarabinomannan based tuberculosis diagnosis
Publication date: Available online 31 July 2020Source: Biosensors and BioelectronicsAuthor(s): Divagar M, Ramakrishna Bandaru, Vani Janakiraman, V.V.R. Sai (Source: Biosensors and Bioelectronics)
Source: Biosensors and Bioelectronics - August 5, 2020 Category: Biotechnology Source Type: research

Genitourinary tuberculosis in 2-year-old indonesian boy with malnutrition: A rare case
Publication date: November 2020Source: Urology Case Reports, Volume 33Author(s): Astrid Kristina Kardani, Krisni Subandiyah (Source: Urology Case Reports)
Source: Urology Case Reports - August 4, 2020 Category: Urology & Nephrology Source Type: research

How COVID-19 could benefit tuberculosis and HIV services in South Africa
Publication date: Available online 3 August 2020Source: The Lancet Respiratory MedicineAuthor(s): Claire Keene, Erika Mohr-Holland, Tali Cassidy, Vera Scott, Aurelie Nelson, Jennifer Furin, Laura Triviño-Duran (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - August 4, 2020 Category: Respiratory Medicine Source Type: research

Furoxan derivatives demonstrated in vivo efficacy by reducing Mycobacterium tuberculosis to undetectable levels in a mouse model of infection
Publication date: October 2020Source: Biomedicine & Pharmacotherapy, Volume 130Author(s): P.C. de Souza, G.F.S. Fernandes, L.B. Marino, C.M. Ribeiro, P.B. da Silva, M. Chorilli, C.S.P. Silva, F.A. Resende, M.C. Solcia, R.A. de Grandis, C.A.S. Costa, S.H. Cho, Y. Wang, S.G. Franzblau, J.L. dos Santos, F.R. Pavan (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - August 4, 2020 Category: Drugs & Pharmacology Source Type: research

GSE102272 The circular RNA of peripheral blood mononuclear cells: hsa_circ_0005836 as a new diagnostic biomarker and therapeutic target of active pulmonary tuberculosis
Contributors : JunFa Xu ; ZeGang Zhuang ; JunAi Zhang ; HouLong Luo ; GanBin Liu ; YuanBin Lu ; NanHai Ge ; BiYing Zheng ; RuiXi Li ; Chen Chen ; Xin Wang ; YuQing Liu ; FengHui Liu ; Yong Zhou ; XiaoZhen Cai ; ZhengW ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensIt has been reported that circular RNA (circRNA) is associated with human cancer. However, few studies have been reported in active pulmonary tuberculosis (APTB). The global circRNA expression was detected in the peripheral blood mononuclear cells (PBMCs) of APTB patients (n=5) and healthy controls (HC) (n=5) by using h...
Source: GEO: Gene Expression Omnibus - August 4, 2020 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

The DNA Damage Inducible SOS Response Is a Key Player in the Generation of Bacterial Persister Cells and Population Wide Tolerance
Population-wide tolerance and persisters enable susceptible bacterial cells to endure hostile environments, including antimicrobial exposure. The SOS response can play a significant role in the generation of persister cells, population-wide tolerance, and shielding. The SOS pathway is an inducible DNA damage repair system that is also pivotal for bacterial adaptation, pathogenesis, and diversification. In addition to the two key SOS regulators, LexA and RecA, some other stressors and stress responses can control SOS factors. Bacteria are exposed to DNA-damaging agents and other environmental and intracellular factors, incl...
Source: Frontiers in Microbiology - August 4, 2020 Category: Microbiology Source Type: research

IJERPH, Vol. 17, Pages 5626: Factors Influencing Patient Adherence to Tuberculosis Treatment in Ethiopia: A Literature Review
Conclusion: Helping patients to achieve full adherence to TB medication is a complex problem as it is influenced by interplay between many factors. Healthcare managers, providers, and researchers need to consider and address multiple underlying factors when designing adherence interventions. This work provides a reference set of such factors for Ethiopian interventions. (Source: International Journal of Environmental Research and Public Health)
Source: International Journal of Environmental Research and Public Health - August 4, 2020 Category: Environmental Health Authors: Zekariyas Sahile Nezenega Lua Perimal-Lewis Anthony John Maeder Tags: Review Source Type: research

Morphological profiling of tubercle bacilli identifies drug pathways of action [Microbiology]
Morphological profiling is a method to classify target pathways of antibacterials based on how bacteria respond to treatment through changes to cellular shape and spatial organization. Here we utilized the cell-to-cell variation in morphological features of Mycobacterium tuberculosis bacilli to develop a rapid profiling platform called Morphological Evaluation and Understanding... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - August 4, 2020 Category: Science Authors: Trever C. Smith II, Krista M. Pullen, Michaela C. Olson, Morgan E. McNellis, Ian Richardson, Sophia Hu, Jonah Larkins-Ford, Xin Wang, Joel S. Freundlich, D. Michael Ando, Bree B. Aldridge Tags: Biological Sciences Source Type: research

Clinical Metagenomic Sequencing for etiological diagnosis in pulmonary tuberculosis suspects
Tuberculosis (TB), which is caused by the bacillus Mycobacterium tuberculosis (MTB), remains a leading cause of death from infectious disease. According to the 2019 World Health Organization global report, TB was one of the top 10 causes of death worldwide, ranking above acquired immune deficiency syndrome. There were an estimated 10.0 million newly diagnosed TB cases worldwide in 2018, with a high incidence and mortality in developing countries1, 2. Although effective treatment has been available for decades, the difficulty faced by physicians has been the issue of rapid and reliable diagnosis. (Source: Journal of Infection)
Source: Journal of Infection - August 4, 2020 Category: Infectious Diseases Authors: Cui-Lin Shi, Peng Han, Pei-Jun Tang, Meng-Meng Chen, Zhi-Jian Ye, Mei-Ying Wu, Jie Shen, Hai-Yan Wu, Zhu-Qing Tan, Xin Yu, Guan-Hua Rao, Jian-Ping Zhang Source Type: research

Is ventilated hospital-acquired pneumonia a worse entity than ventilator-associated pneumonia?
Conclusion Nosocomial pneumonia is a multifaced disease with features of pivotal interest in critical care medicine. Due to the worrisome data on mortality of patients with nosocomial pneumonia, further prospective studies focused on this topic are urgently needed. (Source: European Respiratory Review)
Source: European Respiratory Review - August 4, 2020 Category: Respiratory Medicine Authors: Vallecoccia, M. S., Dominedo, C., Cutuli, S. L., Martin-Loeches, I., Torres, A., De Pascale, G. Tags: Respiratory infections and tuberculosis Reviews Source Type: research

Effect of Nonsteroidal Anti-inflammatory Agents on Small Intestinal Injuries as Evaluated by Capsule Endoscopy
This study aims to investigate whether NSAIDs can cause damage to the small bowel (SB) mucosa.MethodsEndoscopic videos of subjects who had undergone capsule endoscopy (CE) were evaluated by three experts in order to identify SB injury. All medications taken within 2  weeks from the time of CE were investigated. Cases with a final diagnosis of intestinal tuberculosis, inflammatory bowel disease, Behcet’s disease, Peutz–Jeghers syndrome, small bowel lymphoma, or Henoch–Schönlein purpura were excluded from the analysis.ResultsAmong the 273 subjects, 125 (45.8%) had SB erosions or ulcers (erosion gr...
Source: Digestive Diseases and Sciences - August 3, 2020 Category: Gastroenterology Source Type: research

Tuberculosis treatment outcomes of non-citizen migrants: Israel compared to other high-income countries
ConclusionsThere is a need to standardize results based on international definitions of migrants, asylum seekers, and refugees in order to determine status-specific barriers and to facilitate international comparisons. Policies insuring free access to TB care for non-citizen migrants are an important element for TB elimination in low incidence countries. (Source: Israel Journal of Health Policy Research)
Source: Israel Journal of Health Policy Research - August 3, 2020 Category: International Medicine & Public Health Source Type: research

Bactericidal Activity of Liposomal Form of Lytic Mycobacteriophage D29 in Cell Models of Tuberculosis Infection In Vitro
The use of lytic mycobacteriophages to treat tuberculosis under conditions of acquired resistance to anti-tuberculosis drugs is one of the most practical ways to improve the effectiveness of therapy and reduce the spread of this disease. We studied the efficacy of antimycobacterial action of mycobacteriophage D29 encapsulated into 400-nm liposomes in cell models of tuberculosis infectionin vitro. The antimycobacterial action of lytic mycobacteriophage D29 used in free or liposome-encapsulated forms was demonstrated on cell models of intracellularly infected RAW264.7 macrophages and tuberculous granuloma formed by human blo...
Source: Bulletin of Experimental Biology and Medicine - August 3, 2020 Category: Biology Source Type: research

Achieving HIV targets by 2030: the possibility of using debt relief funds for sustainable HIV treatment in sub-Saharan Africa
AbstractThis paper assesses the possibility of using debt relief funds to sustain HIV treatment in sub-Saharan Africa, suppress transmission, and reach global goals to quell the epidemic by 2030. The cost of providing antiretroviral treatment is a huge burden on African countries. Concerns for Africa ’s capacity to keep pace with global advances are well founded. By analysing levels of ‘debt distress’, health expenditure per capita, and HIV antiretroviral therapy requirements in sub-Saharan African countries, the need for innovative finance with international cooperation emerges clearly. I n addition to t...
Source: Journal of Public Health Policy - August 3, 2020 Category: Health Management Source Type: research

Protein expression shift and potential diagnostic markers thorough proteomics profiling of tuberculous pleurisy biopsy tissues
Tuberculosis (TB), caused by bacteria Mycobacterium tuberculosis (M. tuberculosis), is the second leading cause of deaths in infectious diseases around the world. About 10 million patients were diagnosed with TB in 2018, which led to 1.5 million deaths (Organization, 2019a, 2019b). China is one of the countries with a high TB burden in the world, accounting for 9% of the world-wide cases (Mathema et al., 2014). Tuberculous pleurisy (or pleuritis) is a subtype of TB occurring at the surface membrane of the lungs as a result of a response to M. (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - August 3, 2020 Category: Infectious Diseases Authors: Wei-xia Xuan, Jin-jin Li, Qun-cheng Zhang, Guan-nan Sun, Zhi-wei Xu, Zhi-fu Sun, Xiao-ju Zhang Source Type: research

Tuberculosis in the era of COVID-19 in India
Publication date: September–October 2020Source: Diabetes & Metabolic Syndrome: Clinical Research & Reviews, Volume 14, Issue 5Author(s): Vijay Kumar Jain, Karthikeyan P. Iyengar, David Ananth Samy, Raju Vaishya (Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews)
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - August 2, 2020 Category: Endocrinology Source Type: research

Reprocessing of Contaminated MGIT 960 Cultures to Improve Availability of Valid Results for Mycobacteria.
Authors: Subramanyam B, Sivaramakrishnan G, Sangamithrai D, Ravi R, Thiruvengadam K, Vijayaragavan V, Selvaraju A, Tripathy SP, Mondal R Abstract Optimal recovery of mycobacteria from the contaminated liquid culture is a challenge. While alternative methods have been suggested to reduce the rate of contamination in the BACTEC MGIT 960 system, reprocessing the contaminated liquid culture improves recovery of Mycobacterium tuberculosis. Among 793 MGIT cultures raised from as many sputum specimens after primary decontamination by the standard NaLC-NaOH method, valid results were available for 687 (86.6%) as 106 (13.4%...
Source: International Journal of Microbiology - August 2, 2020 Category: Microbiology Tags: Int J Microbiol Source Type: research

Policy Implications of Mathematical Modeling of Latent Tuberculosis Infection Testing and Treatment Strategies to Accelerate Tuberculosis Elimination.
Authors: Marks SM, Dowdy DW, Menzies NA, Shete PB, Salomon JA, Parriott A, Shrestha S, Flood J, Hill AN PMID: 32735183 [PubMed - as supplied by publisher] (Source: Public Health Reports)
Source: Public Health Reports - August 2, 2020 Category: International Medicine & Public Health Tags: Public Health Rep Source Type: research

Leveraging Health Department Capacities, Partnerships, and Health Insurance for Infectious Disease Response in Massachusetts, 2014-2018.
We describe the efforts of the Massachusetts Department of Public Health to integrate its HIV, viral hepatitis, sexually transmitted infection (STI), and tuberculosis response through policies that mandated contracted organizations to submit specimens for testing to the Massachusetts State Public Health Laboratory; co-test blood specimens for HIV, hepatitis C virus (HCV), and syphilis; integrate HIV, viral hepatitis, and STI disease surveillance and case management in a single data system; and implement an integrated infectious disease drug assistance program. From 2014 through 2018, the number of tests performed by the Ma...
Source: Public Health Reports - August 2, 2020 Category: International Medicine & Public Health Tags: Public Health Rep Source Type: research

Modeling the Impact of Recommendations for Primary Care-Based Screening for Latent Tuberculosis Infection in California.
CONCLUSIONS: By focusing on the non-US-born population, adherence to LTBI testing strategies recommended by the USPSTF and the California tool could substantially reduce the burden of TB disease in California in the next decade. PMID: 32735191 [PubMed - as supplied by publisher] (Source: Public Health Reports)
Source: Public Health Reports - August 2, 2020 Category: International Medicine & Public Health Tags: Public Health Rep Source Type: research

Impact of Targeted Local Interventions on Tuberculosis Awareness and Screening Among Persons Experiencing Homelessness During a Large Tuberculosis Outbreak in Atlanta, Georgia, 2015-2016.
CONCLUSIONS: Implementation of required TB screening and educational interventions may reduce the incidence and severity of TB outbreaks among PEH in other communities. Furthermore, the annual survey of PEH offers an opportunity to collect data to better inform practices and policies. PMID: 32735200 [PubMed - as supplied by publisher] (Source: Public Health Reports)
Source: Public Health Reports - August 2, 2020 Category: International Medicine & Public Health Tags: Public Health Rep Source Type: research

Performance of the Roche cobas MTB assay for the molecular diagnosis of pulmonary tuberculosis in a high HIV burden setting
Publication date: Available online 1 August 2020Source: The Journal of Molecular DiagnosticsAuthor(s): Lesley Scott, Anura David, Lyndel Govender, Jan Furrer, Modiehi Rakgokong, Ziyaad Waja, Neil Martinson, Gabriel Eisenberg, Elizabeth Marlowe, Wendy Stevens (Source: The Journal of Molecular Diagnostics)
Source: The Journal of Molecular Diagnostics - August 1, 2020 Category: Pathology Source Type: research

Genital-peritoneal tuberculosis: A case with different diagnostic work up
Publication date: Available online 16 July 2020Source: European Journal of Obstetrics & Gynecology and Reproductive BiologyAuthor(s): Orsola Brasile, Ruby Martinello, Gennaro Scutiero, Pantaleo Greco (Source: European Journal of Obstetrics and Gynecology and Reproductive Biology)
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - August 1, 2020 Category: OBGYN Source Type: research

GSE118482 Effect of 6-azasteroids on Mycobacterium tuberculosis wild type and 6-azasteroid resistant mutants
Contributors : Xinxin Yang ; Nicole S SampsonSeries Type : Expression profiling by high throughput sequencingOrganism : Mycobacterium tuberculosisTranscriptional profiling of Mycobacterium tuberculosis CDC1551 and 6-azasteroid resistant mutants ASR1 and ASR2 with treatment of 6-azasteroids, 4a and 6a, for 6 hours. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - August 1, 2020 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mycobacterium tuberculosis Source Type: research

Perspectives and practices of health workers around diagnosis of paediatric tuberculosis in hospitals in a resource-poor setting – modern diagnostics meet age-old challenges
Detection of tuberculosis (TB) in children in Kenya is sub-optimal. Xpert MTB/RIF ® assay (Xpert®) has the potential to improve speed of TB diagnosis due to its sensitivity and fast turnaround for results. Sign... (Source: BMC Health Services Research)
Source: BMC Health Services Research - August 1, 2020 Category: General Medicine Authors: Jacquie Narotso Oliwa, Sabina Adhiambo Odero, Jacinta Nzinga, Micha ël Boele van Hensbroek, Caroline Jones, Mike English and Anja van’t Hoog Tags: Research article Source Type: research

Vaginal tuberculosis as differential diagnosis of cancer: A case report
Publication date: 2020Source: IDCases, Volume 21Author(s): Isis Carton, Diane Balès, Alain Bargain, Pascale Le Pors Lemoine (Source: IDCases)
Source: IDCases - August 1, 2020 Category: Infectious Diseases Source Type: research

Changes in T-lymphocyte subsets and risk factors in human immunodeficiency virus-negative patients with active tuberculosis
AbstractPurposeImmune function imbalance is closely associated with the occurrence and development of infectious diseases. We studied the characteristics of changes in T-lymphocyte subsets and their risk factors in HIV-negative patients with active tuberculosis (ATB).MethodsT-lymphocyte subsets in 275 HIV-negative ATB patients were quantitatively analyzed and compared with anMycobacteriumtuberculosis-free control group. Single-factor and multifactor analyses of clinical and laboratory characteristics of patients were also conducted.ResultsIn ATB patients, CD4 and CD8 T-cell counts decreased, and the levels were positively ...
Source: Infection - August 1, 2020 Category: Infectious Diseases Source Type: research

The protein kinase PknB negatively regulates biosynthesis and trafficking of mycolic acids in mycobacteria [Research Articles]
Mycobacterium tuberculosis is the causative agent of tuberculosis and remains one of the most widespread and deadliest bacterial pathogens in the world. A distinguishing feature of mycobacteria that sets them apart from other bacteria is the unique architecture of their cell wall, characterized by various species-specific lipids, most notably mycolic acids (MAs). Therefore, targeted inhibition of enzymes involved in MA biosynthesis, transport, and assembly has been extensively explored in drug discovery. Additionally, more recent evidence suggests that many enzymes in the MA biosynthesis pathway are regulated by kinase-med...
Source: The Journal of Lipid Research - August 1, 2020 Category: Lipidology Authors: Le, N.-H., Locard-Paulet, M., Stella, A., Tomas, N., Molle, V., Burlet-Schiltz, O., Daffe, M., Marrakchi, H. Tags: Research Articles Source Type: research

Tuberculosis and viral hepatitis in patients treated with certolizumab pegol in Asia-Pacific countries and worldwide: real-world and clinical trial data
ConclusionsCZP TB risk is aligned with nationwide TB rates, being slightly higher in Asia-Pacific countries excluding Japan. Overall, TB and HBV/HCV risk with CZP treatment is currently relatively low, as risk can be minimized with patient/physician education, screening, and vigilant treatment, according to international guidelines.Key Points:• TB rates were highest in eastern/central Europe, Mexico, and Asia-Pacific regions.• With the implementation of stricter TB screening and risk evaluations in 2007, especially in high TB incidence countries, there was a notable reduction TB occurrence.• Safety profile o...
Source: Clinical Rheumatology - August 1, 2020 Category: Rheumatology Source Type: research

Pulmonary nocardiosis with superior vena cava syndrome in HIV-infected patient: A rare case report in the world.
Abstract Pulmonary nocardiosis is a common disease among HIV-infected patients. In most cases, the disease progresses slowly. Here, we present a case whose disease progressed rapidly. A 35-year-old female with AIDS and superior vena cava (SVC) syndrome who was lost to follow-up visited our hospital. She presented with a chronic non-productive cough and her CD4 count was 33 (4%). Her chest x-ray showed opacity in the right upper lobe of her lung and her sputum acid-fast stain was negative. Anti-tuberculosis agents were prescribed. Two weeks later, superficial vein dilatation appeared on her chest wall and her chest...
Source: Japanese Journal of Infectious Diseases - August 1, 2020 Category: Infectious Diseases Authors: Kiatsuranon P, Suwanpimolkul G Tags: Jpn J Infect Dis Source Type: research

Preterm twins from the mother with miliary tuberculosis: Importance of early recognition and prompt response in infection control to manage congenital tuberculosis exposure in a neonatal intensive care unit.
Abstract Delayed diagnosis of congenital tuberculosis (TB) in a neonatal intensive care unit (NICU) is a serious problem in terms of infection control. Here, we report our preemptive infection control activities implemented after the diagnosis of miliary TB in a mother of preterm twins (index twins, NB1 and NB2) in NICU. Added to this, we reviewed previous case reports of congenital TB exposure in the NICU setting. Immediately after recognizing miliary TB of the mother, the index twins were isolated before their TB diagnosis and received preemptive antiTB medication, and contact investigations were also conducted....
Source: Japanese Journal of Infectious Diseases - August 1, 2020 Category: Infectious Diseases Authors: Ryu BH, Baek EH, Kim DH, Kim SE, Kim HJ, Cho OH, Hong SI, Do HJ, Park CH Tags: Jpn J Infect Dis Source Type: research

How to treat patients after serious adverse effects caused by tnf inhibitors?
We report on serious adverse events during treatment with anti-tumor necrosis factor antibody in two of our patients with juvenile idiopathic arthritis. One patient was treated with a biological agent due to juvenile idiopathic arthritis complicated by uveitis, developing miliary tuberculosis during treatment. After treatment with antituberculotics, she recovered completely. Her underlying disease is currently in remission. Another patient was treated for juvenile spondyloarthritis and developed an inflammatory process of the central nervous system with serious neurological deficits. He was treated with high-dose corticost...
Source: Acta Clinica Croatica - July 31, 2020 Category: General Medicine Tags: Acta Clin Croat Source Type: research

Determine TB-LAM point-of-care tuberculosis assay predicts poor outcomes in outpatients during their first year of antiretroviral therapy in South Africa
Determine TB-LAM is the first point-of-care test (POC) for HIV-associated tuberculosis (TB) and rapidly identifies TB in those at high-risk for short-term mortality. While the relationship between urine-LAM an... (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - July 31, 2020 Category: Infectious Diseases Authors: Andrew D. Kerkhoff, Nicky Longley, Nicola Kelly, Anna Cross, Monica Vogt, Robin Wood, Sabine Hermans, Stephen D. Lawn and Thomas S. Harrison Tags: Research article Source Type: research

Prevalence and risk factors of paradoxical tuberculosis associated immune reconstitution inflammatory syndrome among HIV-infected patients in Beijing, China
In this study, we aimed to describe the prevalence, clinical presentation and risk factors of paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) cases in China. (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - July 31, 2020 Category: Infectious Diseases Authors: Ming Xue, Ruming Xie, Yu Pang, Shuo Yan, Yanni Du, Chunshuang Guan and Budong Chen Tags: Research article Source Type: research

Tuberculosis Chemotherapy Outcome in the Littoral Region of Cameroon: A Meta-analysis of Treatment Success Rate between 2014 and 2016.
Conclusion: An improvement in the reduction of percentage of lost to follow-up and coverage with CTX and ARV therapy could greatly increase chances to efficiently control TB in Cameroon. PMID: 32724812 [PubMed - as supplied by publisher] (Source: Biomed Res)
Source: Biomed Res - July 31, 2020 Category: Research Authors: Kouemo Motse DF, Nsagha DS, Adiogo D, Kojom Foko LP, Teyim PM, Chichom-Mefire A, Nguedia Assob JC Tags: Biomed Res Int Source Type: research

Gut microbiome a promising target for management of respiratory diseases.
Abstract The intestinal microbial flora has risen to be one of the important etiological factors in the development of diseases like colorectal cancer, obesity, diabetes, inflammatory bowel disease, anxiety and Parkinson's. The emergence of the association between bacterial flora and lungs led to the discovery of the gut-lung axis. Dysbiosis of several species of colonic bacteria such as Firmicutes and Bacteroidetes and transfer of these bacteria from gut to lungs via lymphatic and systemic circulation are associated with several respiratory diseases such as lung cancer, asthma, tuberculosis, cystic fibrosis, etc....
Source: The Biochemical Journal - July 31, 2020 Category: Biochemistry Authors: Trivedi R, Barve K Tags: Biochem J Source Type: research

Risk factors for mortality among drug-resistant tuberculosis patients registered for drug-resistant treatment in Amhara region, Ethiopia: a historical cohort study
ConclusionsThis study concluded that drug-resistant tuberculosis mortality remains high in the study site. Age 45  years and above, smoking cigarette, tuberculosis related clinical complication, being anemic at baseline, HIV/AID, previous tuberculosis treatment history, and diabetes mellitus were identified risk factors for mortality. Continual support of the integration of TB/HIV service with emphasis and wo rking on identified risk factors may help in reducing drug-resistant tuberculosis mortality. (Source: Archives of Public Health)
Source: Archives of Public Health - July 31, 2020 Category: International Medicine & Public Health Source Type: research

Corrigendum: IL-2 Restores T-Cell Dysfunction Induced by Persistent Mycobacterium tuberculosis Antigen Stimulation
(Source: Frontiers in Immunology)
Source: Frontiers in Immunology - July 31, 2020 Category: Allergy & Immunology Source Type: research

Performance of the Roche cobas MTB assay for the molecular diagnosis of pulmonary tuberculosis in a high HIV burden setting
There is a need to increase access to and improve sensitivities of methods for diagnosing Mycobacterium tuberculosis infection and for detecting rifampicin and isoniazid resistance. The performance of the new cobas MTB assay for use on cobas 6800/8800 Systems (Roche) was assessed in this study and compared to two other commercial assays: Real-Time MTB (Abbott), and Xpert MTB/RIF (Cepheid).Molecular PCR-based assays were conducted on sputum specimens collected from individuals with presumptive and confirmed TB (n=294) from two clinical facilities in South Africa from December 2016 to October 2017. (Source: Journal of Molecular Diagnostics)
Source: Journal of Molecular Diagnostics - July 31, 2020 Category: Pathology Authors: Lesley Scott, Anura David, Lyndel Govender, Jan Furrer, Modiehi Rakgokong, Ziyaad Waja, Neil Martinson, Gabriel Eisenberg, Elizabeth Marlowe, Wendy Stevens Tags: Regular Article Source Type: research

Summary for Clinicians: 2019 Clinical Practice Guideline Summary for the Treatment of Drug-Resistant Tuberculosis
Annals of the American Thoracic Society,Volume 17, Issue 8, Page 911-917, August 2020. (Source: Annals of the American Thoracic Society)
Source: Annals of the American Thoracic Society - July 31, 2020 Category: Respiratory Medicine Authors: Christopher A. Berger Narges Alipanah Fayez Kheir Joseph K. Ruminjo Payam Nahid Carey Thomson Source Type: research

Essential Components of a Public Health Tuberculosis Prevention, Control, and Elimination Program: Recommendations of the Advisory Council for the Elimination of Tuberculosis and the National Tuberculosis Controllers Association.
This report provides an introduction and reference tool for tuberculosis (TB) controllers regarding the essential components of a public health program to prevent, control, and eliminate TB. The Advisory Council for the Elimination of Tuberculosis and the National Tuberculosis Controllers Association recommendations in this report update those previously published (Advisory Council for the Elimination of Tuberculosis. Essential components of a tuberculosis prevention and control program. Recommendations of the Advisory Council for the Elimination of Tuberculosis. MMWR Recomm Rep 1995;44[No. RR-11]). The report has been wri...
Source: MMWR Recomm Rep - July 31, 2020 Category: Epidemiology Authors: Cole B, Nilsen DM, Will L, Etkind SC, Burgos M, Chorba T Tags: MMWR Recomm Rep Source Type: research

Inhibition studies of ketol-acid reductoisomerases from pathogenic microorganisms.
Abstract Ketol-acid reductoisomerase (KARI), the second enzyme in the branched-chain amino acid (BCAA) biosynthesis pathway, is an emerging target for the discovery of biocides. Here, we demonstrate that cyclopropane-1,1-dicarboxylate (CPD) inhibits KARIs from the pathogens Mycobacterium tuberculosis (Mt) and Campylobacter jejuni (Cj) reversibly with Ki values of 3.03 μM and 0.59 μM, respectively. Another reversible inhibitor of both KARIs, Hoe 704, is more potent than CPD with Ki values of 300 nM and 110 nM for MtKARI and CjKARI, respectively. The most potent inhibitor tested here is N-hydroxy-N-iso...
Source: Archives of Biochemistry and Biophysics - July 31, 2020 Category: Biochemistry Authors: Wun SJ, Johnson LA, You L, McGeary RP, Brueck T, Schenk G, Guddat LW Tags: Arch Biochem Biophys Source Type: research

[Using of the Sensititre MycoTB Plate Method for the Detection of Anti-tuberculous Drug Susceptibility of Rifampin Resistant Mycobacterium tuberculosis Complex Isolates].
In this study, it was aimed to evaluate whether the Sensititre MycoTB plaque method is suitable for the routine use in determining drug susceptibility of rifampin resistant MTBC strains. Xpert MTBC/ RIF positive rifampin resistant 100 MTBC isolates were included in the study. Xpert MTBC/RIF (Cepheid, USA) test were performed after the samples were processed by homogenization and decontamination and acid-fast staining. Rifampin resistant clinical samples were cultured in automated MGIT/BACTEC 960 (Becton Dickinson, USA) system and acid fast bacteria (AFB) were investigated. The anti-TB drug susceptibility tests of all cultu...
Source: Mikrobiyoloji Bulteni - July 30, 2020 Category: Microbiology Tags: Mikrobiyol Bul Source Type: research

Identification and Treatment of Tuberculosis in Pediatric Recipients of Allogeneic Hematopoietic Stem Cell Transplantation: Case Series and Review of the Literature
(Source: Infection and Drug Resistance)
Source: Infection and Drug Resistance - July 30, 2020 Category: Infectious Diseases Tags: Infection and Drug Resistance Source Type: research

To Pool or Not to Pool Samples for Sexually Transmitted Infections Detection in Men Who Have Sex With Men? An Evaluation of a New Pooling Method Using the GeneXpert Instrument in West Africa
Conclusions West African MSM have a high prevalence of extragenital and asymptomatic STIs. The GeneXpert method provides an opportunity to move from syndromic toward etiological STI diagnosis in low-income countries, as the platform is available in African countries for tuberculosis testing. Pooling will reduce costs of triple site testing. (Source: Sexually Transmitted Diseases)
Source: Sexually Transmitted Diseases - July 30, 2020 Category: Sexual Medicine Tags: Original Studies Source Type: research

The Impact of HIV Infection on TB Disparities Among US-Born Black and White Tuberculosis Patients in the United States
Conclusions: Black TB patients had greater HIV prevalence than whites. While mortality was associated with HIV infection, it was not significantly associated with black or white race. (Source: Journal of Public Health Management and Practice)
Source: Journal of Public Health Management and Practice - July 30, 2020 Category: Health Management Tags: Research Reports Source Type: research

Ramadan and Culturally Competent Care: Strengthening Tuberculosis Protections for Recently Resettled Muslim Refugees
To improve latent tuberculosis infection treatment completion rates, Tarrant County Public Health began providing after-dusk home delivery of a 12-dose latent tuberculosis infection regimen of weekly rifapentine plus isoniazid administered via directly observed preventive therapy during Ramadan, a month of prayer and daytime fasting observed by Muslims. In unadjusted difference-in-difference logistic regression analyses (n = 148), Muslim patients had lower treatment completion rates than non-Muslim patients during Ramadan prior to program implementation (68.8% vs 95.4%), whereas rates were comparable postimplementation (95...
Source: Journal of Public Health Management and Practice - July 30, 2020 Category: Health Management Tags: Research Reports Source Type: research

Risk stratification and management of QuantiFERON-positive solid-organ living donors
Purpose of review Donor-derived disease with Mycobacterium tuberculosis (MTB) is likely to become more common as donor pools expand due to increasing transplant volume coupled with patterns of migration and global mobility. Our article reviews the current literature and provides a rational approach for clinicians managing the scenario of a living donor who has epidemiologic risk factors for tuberculosis exposure. Recent findings Tuberculous bacilli, formerly thought to exist latently only in pulmonary granulomas, are now known reside dormant in nonpulmonary organs. Kidney and liver grafts are thus vectors for donor tr...
Source: Current Opinion in Organ Transplantation - July 30, 2020 Category: Surgery Tags: INFECTIOUS DISEASES: Edited by Emily Blodget Source Type: research

Tuberculous Dactylitis: A Rare Form of Skeletal Tuberculosis
No abstract available (Source: JCR: Journal of Clinical Rheumatology)
Source: JCR: Journal of Clinical Rheumatology - July 30, 2020 Category: Rheumatology Tags: Images Source Type: research

Organ Doses from Chest Radiographs in Tuberculosis Patients in Canada and Their Uncertainties in Periods from 1930 to 1969
This paper describes a study to estimate absorbed doses to various organs from film-based chest radiographs and their uncertainties in the periods 1930 to 1948, 1949 to 1955, and 1956 to 1969. Estimated organ doses will be used in new analyses of risks of cancer and other diseases in tuberculosis patients in Canada who had chest fluoroscopic and radiographic examinations in those periods. In this paper, doses to lungs, female breast, active bone marrow, and heart from a single chest radiograph in adults and children of ages 1, 5, 10, and 15 y in the Canadian cohort and their uncertainties are estimated using (1) data on th...
Source: Health Physics - July 30, 2020 Category: Radiology Tags: PAPERS Source Type: research