Fight Aging! Newsletter, November 19th 2018

Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is published under the Creative Commons Attribution 4.0 International License. You are encouraged to republish and rewrite it in any way you see fit, the only requirements being that you provide attribution and a link to Fight Aging! To subscribe or unsubscribe please visit: https://www.fightaging.org/newsletter/ Contents A Mechanism by which Autoimmunity Raises the Risk of Cardiovascular Disease More Evidence for the Genetic Contribution to Longevity to be Smaller than Suspected Senolytic Therapeutics Uses Nanotube-Carried Toxins to Destroy Senescent Cells Jim Mellon Donates 100,000 to the SENS Research Foundation Year End Fundraiser The Milken Institute's Longevity Innovators Interviews Even Mild Hypertension is Harmful to Health Extracellular NAD+ Declines with Age A Popular Science View of Checkpoint Inhibitor Cancer Immu...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs

Related Links:

Notch signaling is a highly conserved intercellular pathway with tightly regulated and pleiotropic roles in normal tissue development and homeostasis. Dysregulated Notch signaling has also been implicated in human disease, including multiple forms of cancer, and represents an emerging therapeutic target. Successful development of such therapeutics requires a detailed understanding of potential on-target toxicities. Here, we identify autosomal dominant mutations of the canonical Notch ligand Jagged1 (or JAG1) as a cause of peripheral nerve disease in 2 unrelated families with the hereditary axonal neuropathy Charcot-Marie-T...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
The ATP-sensitive K+ channel (KATP) is formed by the association of four inwardly rectifying K+ channel (Kir6.x) pore subunits with four sulphonylurea receptor (SUR) regulatory subunits. Kir6.x or SUR mutations result in KATP channelopathies, which reflect the physiological roles of these channels, including but not limited to insulin secretion, cardiac protection, and blood flow regulation. In this issue of the JCI, McClenaghan et al. explored one of the channelopathies, namely Cantu syndrome (CS), which is a result of one kind of KATP channel mutation. Using a knockin mouse model, the authors demonstrated that gain-of-fu...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Staphylococcus aureus remains a leading cause of human infection. These infections frequently recur when the skin is a primary site of infection, especially in infants and children. In contrast, invasive staphylococcal disease is less commonly associated with reinfection, suggesting that tissue-specific mechanisms govern the development of immunity. Knowledge of how S. aureus manipulates protective immunity has been hampered by a lack of antigen-specific models to interrogate the T cell response. Using a chicken egg OVA–expressing S. aureus strain to analyze OVA-specific T cell responses, we demonstrated that primary...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
[Botswana Daily News] Mahalapye -The Faith and Community Initiative Project aimed at combating HIV/AIDS in Botswana brings a message of hope to the country, says Vice President Slumber Tsogwane.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
Publication date: Available online 17 February 2020Source: Clinical Epidemiology and Global HealthAuthor(s): Krishna Prasad Acharya, Niran Adhikari, Muhammad TariqAbstractThe agro-climatic conditions, socio-economic situation, poor sanitation, low hygiene and health standards in Nepal are major contributing factors to the emergence of scrub typhus in Nepal. These outbreaks, along with poor diagnostic facilities, can lead to severe economic losses in a resource-limited country like Nepal. Diseases like avian influenza, leptospirosis, brucellosis, tuberculosis and rabies, that cause heavy socio-economic burden, have received...
Source: Clinical Epidemiology and Global Health - Category: Epidemiology Source Type: research
Over 90% of suicides in the West could be diagnosed with mental disorders, while only 50-70% of Chinese suicides had mental disorders. Using data from a case-control study on suicide attempt, we aimed to compare characteristics and risk factors between sui...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Rural and Agricultural Issues Source Type: news
BACKGROUND: A previous study in Japan found that monthly mean K index values were related to the monthly number of male, but not female, suicides. Correlations between geomagnetic disturbances and suicide/depression have also been reported in countries suc...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
BACKGROUND AND OBJECTIVE: Unipolar depression is the most common form of depression and demand for treatment, such as psychotherapy, is high. However, waiting times for psychotherapy often considerably exceed their recommended maximum. As a potentially les...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
We examined as...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
Adolescence is a key window of vulnerability for depression, the leading cause of disability worldwide. The prevention of depression among young people is therefore of substantial public health importance. A growing body of large-scale data now support...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
More News: Academia | African Health | AIDS Vaccine | Alopecia | Alzheimer's | Arthritis | Aspirin | Atrial Fibrillation | Autoimmune Disease | Azithromycin | Biochemistry | Biotechnology | Brain | Brain Cancers | Cancer | Cancer & Oncology | Cancer Vaccines | Cardiology | Cardiovascular | Chemistry | Chemotherapy | Child Abuse | Child Development | Children | Cholesterol | Clinical Trials | Colorectal Cancer | Databases & Libraries | Dementia | Depression | Diabetes | Diabetes Mellitus | Diabetes Type 2 | Diets | Disability | Endocrinology | Environmental Health | Fortamet | Fruit | Gastroschisis Repair | Gene Therapy | Genetics | Grants | Heart | Heart Attack | Heart Disease | Heart Failure | History of Medicine | HIV AIDS | Hyperactivity | Hypertension | Immunotherapy | Insulin | Internet | Laboratory Medicine | Lupus | Melanoma | Men | Metformin | Mitochondria | Mitochondrial Disease | Molecular Biology | Nanotechnology | Neurology | Neuroscience | Niacin | Nutrition | Osteoarthritis | Pancreas | Pancreatic Cancer | Parkinson's Disease | Pathology | Pensions | Pneomococcal Vaccine | Pneumonia | Politics | Psoriasis | Research | Rheumatoid Arthritis | Rheumatology | Science | Skin | Skin Cancer | Smallpox | Smallpox Vaccine | Spinal Cord Injury | Sports Medicine | Stroke | Study | Substance Abuse | Sugar | Suicide | Switzerland Health | Toxicology | Tuberculosis | Turmeric | Urinary Tract Infections | Urology & Nephrology | Vaccines | Vegetables | Venture Capital | Veterinary Vaccinations | Yervoy | Zithromax