Fight Aging! Newsletter, November 19th 2018

Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is published under the Creative Commons Attribution 4.0 International License. You are encouraged to republish and rewrite it in any way you see fit, the only requirements being that you provide attribution and a link to Fight Aging! To subscribe or unsubscribe please visit: https://www.fightaging.org/newsletter/ Contents A Mechanism by which Autoimmunity Raises the Risk of Cardiovascular Disease More Evidence for the Genetic Contribution to Longevity to be Smaller than Suspected Senolytic Therapeutics Uses Nanotube-Carried Toxins to Destroy Senescent Cells Jim Mellon Donates 100,000 to the SENS Research Foundation Year End Fundraiser The Milken Institute's Longevity Innovators Interviews Even Mild Hypertension is Harmful to Health Extracellular NAD+ Declines with Age A Popular Science View of Checkpoint Inhibitor Cancer Immu...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs

Related Links:

Authors: Li Q, Zhang A, Xing C, Yuan Y Abstract Chronic kidney disease (CKD) is recognized as a worldwide health problem. Progression of CKD may lead to many serious complications, which are associated with increased morbidity and mortality. Presently, there is no satisfactory treatment. Thus, targeted therapies are urgently needed. The kidneys are second to the heart in terms of mitochondrial abundance and oxygen consumption. Thus, it is not surprising that mitochondrial homeostasis is absolutely essential for the normal function of the kidney. In fact, a number of reports indicate that mitochondria are involved i...
Source: Histology and Histopathology - Category: Cytology Tags: Histol Histopathol Source Type: research
Authors: Li T, Han J, Jia L, Hu X, Chen L, Wang Y Abstract A change in the metabolic flux of glucose from mitochondrial oxidative phosphorylation (OXPHOS) to aerobic glycolysis is regarded as one hallmark of cancer. However, the mechanisms underlying the metabolic switch between aerobic glycolysis and OXPHOS are unclear. Here we show that the M2 isoform of pyruvate kinase (PKM2), one of the rate-limiting enzymes in glycolysis, interacts with mitofusin 2 (MFN2), a key regulator of mitochondrial fusion, to promote mitochondrial fusion and OXPHOS, and attenuate glycolysis. mTOR increases the PKM2:MFN2 interaction by p...
Source: Protein and Cell - Category: Cytology Tags: Protein Cell Source Type: research
Authors: Han L, Zhang JJ, Jing HF, Qin L Abstract Acute ST-segment elevation myocardial infarction (STEMI) is one of the most common cardiovascular emergencies. With the improvement of living standards, the incidence and mortality rate of STEMI has shown a significant growth trend. PMID: 30892000 [PubMed - as supplied by publisher]
Source: Journal of Biological Regulators and Homeostatic Agents - Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research
In conclusion, CD133 promoted the upregulation of CSC/TSC-related genes in glioma cells, while enhancing the neurosphere-forming ability and in-vivo oncogenicity. PMID: 30891998 [PubMed - as supplied by publisher]
Source: Journal of Biological Regulators and Homeostatic Agents - Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research
Conclusions: tTGIgA were increasingly tested, while the rate of positive results decreased in recent years, possibly reflecting the impact of current alimentary trends on clinical practice. Associated autoimmune disease was frequently found in CD. High levels of tTGIgA accurately predicted CD diagnosis. WA was rarely investigated and deserves more attention, in particular in children with atopic background. WA does not seem to be associated with CD.Int Arch Allergy Immunol
Source: International Archives of Allergy and Immunology - Category: Allergy & Immunology Source Type: research
Conclusions: Lifetime cannabis use is associated with better working memory and processing speed and worse real-world functioning in the area of socially useful activities in patients with schizophrenia-related disorders. Clinicians should, therefore, be aware of it to provide patient-centred care in their daily clinical practice.Eur Addict Res 2019;25:111 –118
Source: European Addiction Research - Category: Addiction Source Type: research
The objective of this paper is to analyse how narratives targeting ambitions and self-realisation in work life are expressed by individuals with HFA in relation to the citizen-worker discourse. This ethnographic study comprises 26 qualitative interview narratives by 11 participants with HFA. Findings indicate that the participants have developed a strong citizen-worker identity. The will is an essential point of gravity, expressed through notions of individual meaningfulness and ambitions of being perceived as resources in any vocational context. Barriers to these ambitions are experienced as personally counteractive suppo...
Source: ALTER - European Journal of Disability Research - Category: Disability Source Type: research
Authors: Lamain-de Ruiter M, Kwee A, Naaktgeboren CA, Louhanepessy RD, De Groot I, Evers IM, Groenendaal F, Hering YR, Huisjes AJM, Kirpestein C, Monincx WM, Schielen PCJI, Van 't Zelfde A, Van Oirschot CM, Vankan-Buitelaar SA, Vonk MAAW, Wiegers TA, Zwart JJ, Moons KGM, Franx A, Koster MPH Abstract OBJECTIVE: To perform an external validation of all published prognostic models for first-trimester prediction of the risk of developing preeclampsia (PE). METHODS: Women
Source: Hypertension in Pregnancy - Category: OBGYN Tags: Hypertens Pregnancy Source Type: research
Publication date: June 2019Source: Nano Energy, Volume 60Author(s): Yanfen Wen, Jingjing Fan, Chenguang Shi, Peng Dai, Yuhao Hong, Ruixiang Wang, Lina Wu, Zhiyou Zhou, Juntao Li, Ling Huang, Shi-Gang SunAbstractAs a cost-effective element, Mg has been applied as doped inactive atom to improve the electrochemical performance of sodium-ion cathode materials. Herein, we report Mg-substituted Na0.67Mn0.65Ni0.2Co0.15-xMgxO2 composites as high-performance cathode for sodium-ion batteries and investigate the underlying working mechanism using in situ investigation techniques to monitor the operando changes of electrodes. In situ ...
Source: Nano Energy - Category: Nanotechnology Source Type: research
This study demonstrates a simple one-pot green method for biosynthesis of terpenoids encapsulated copper oxide nanoparticles (CuONPs) using aqueous leaf extract of Eucalyptus globulus (ELE), as reducing, dispersing, and stabilizing agent. Indeed, the greater attachment and internalization of ELE-CuONPs in Gram-positive and -negative biofilm producing clinical bacterial isolates validated the hypothesis that terpenoids encapsulated CuONPs are more stable and effective antibacterial and antibiofilm agent vis-à-vis commercially available nano and micro sized analogues. Gas chromatography-mass spectroscopy (GC–MS)...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
More News: Academia | African Health | AIDS Vaccine | Alopecia | Alzheimer's | Arthritis | Aspirin | Atrial Fibrillation | Autoimmune Disease | Azithromycin | Biochemistry | Biotechnology | Brain | Brain Cancers | Cancer | Cancer & Oncology | Cancer Vaccines | Cardiology | Cardiovascular | Chemistry | Chemotherapy | Child Abuse | Child Development | Children | Cholesterol | Clinical Trials | Colorectal Cancer | Databases & Libraries | Dementia | Depression | Diabetes | Diabetes Mellitus | Diabetes Type 2 | Diets | Disability | Endocrinology | Environmental Health | Fortamet | Fruit | Gastroschisis Repair | Gene Therapy | Genetics | Grants | Heart | Heart Attack | Heart Disease | Heart Failure | History of Medicine | HIV AIDS | Hyperactivity | Hypertension | Immunotherapy | Insulin | Internet | Laboratory Medicine | Lupus | Melanoma | Men | Metformin | Mitochondria | Mitochondrial Disease | Molecular Biology | Nanotechnology | Neurology | Neuroscience | Niacin | Nutrition | Osteoarthritis | Pancreas | Pancreatic Cancer | Parkinson's Disease | Pathology | Pensions | Pneomococcal Vaccine | Pneumonia | Politics | Psoriasis | Research | Rheumatoid Arthritis | Rheumatology | Science | Skin | Skin Cancer | Smallpox | Smallpox Vaccine | Spinal Cord Injury | Sports Medicine | Stroke | Study | Substance Abuse | Sugar | Suicide | Switzerland Health | Toxicology | Tuberculosis | Turmeric | Urinary Tract Infections | Urology & Nephrology | Vaccines | Vegetables | Venture Capital | Veterinary Vaccinations | Yervoy | Zithromax