Women complain of 'confusing and contradictory' fertility advice
Royal College says sheer volume and variability of advice is causing widespread concern Related items fromOnMedica Epilepsy does not affect chance of pregnancy, or outcomes Most CCGs missing smoking target for pregnant women Colleges urge GPs to take on maternity care Prenatal vitamins linked to lower ASD risk in siblings Blood test identifies high-risk lupus pregnancies (Source: OnMedica Latest News)
Source: OnMedica Latest News - March 14, 2019 Category: UK Health Source Type: news

Beyond Cancer: CAR T-Cell Therapy Now Investigated in Lupus Beyond Cancer: CAR T-Cell Therapy Now Investigated in Lupus
CAR T-cell therapy extended survival and deferred manifestations of lupus in mouse models.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - March 12, 2019 Category: Consumer Health News Tags: Rheumatology News Source Type: news

Lower Lupus Activity, Lower Mortality
(MedPage Today) -- Study shows benefit of achieving low disease activity (Source: MedPage Today Primary Care)
Source: MedPage Today Primary Care - March 9, 2019 Category: Primary Care Source Type: news

CAR T Cells Treat Lupus in Mice
T cells modified to target disease-contributing B cells improved survival in two mouse models of the autoimmune disease. (Source: The Scientist)
Source: The Scientist - March 6, 2019 Category: Science Tags: News & Opinion Source Type: news

Autoimmune rheumatic disease: Mayo Clinic Radio Health Minute
Rheumatoid arthritis, lupus and vasculitis are just a few examples of autoimmune rheumatic diseases. ?In this Mayo Clinic Radio Health Minute, Dr. Eric Matteson talks about the prevalence of these types of diseases and where treatment is headed. To listen, click the link below. Autoimmune rheumatic disease (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - March 6, 2019 Category: Databases & Libraries Source Type: news

UCLA-led study could point to ways to better control inflammation in autoimmune diseases
In autoimmune diseases such as psoriasis or lupus, the immune system goes into overdrive in response to people ’s own DNA being released from damaged cells — a reaction that can cause severe inflammation in the body.Until now, the molecular processes behind that immune response have not been fully understood by scientists, but a new UCLA-led study could help change that.Researchers at UCLA and three other institutions discovered that LL37 molecules, which are found in the immune system, play an important but unexpected role in revving up the body ’s self-defense response. The finding may bring scientists ...
Source: UCLA Newsroom: Health Sciences - March 5, 2019 Category: Universities & Medical Training Source Type: news

Lupus and the Microbiome
(MedPage Today) -- New study finds gut bacteria may drive disease activity (Source: MedPage Today Gastroenterology)
Source: MedPage Today Gastroenterology - March 2, 2019 Category: Gastroenterology Source Type: news

Gut Microbes May Predict Lupus Flares Gut Microbes May Predict Lupus Flares
Disease flares in patients with lupus may be linked to decreased diversity of gut microbes and intestinal permeability, a study found.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - February 26, 2019 Category: Consumer Health News Tags: Rheumatology News Source Type: news

What Is the Most Common Type of Cardiomyopathy?
Discussion Barth syndrome is characterized by a dilated cardiomyopathy, proximal skeletal muscle weakness, neutropenia and short stature that usually presents at birth or soon after. It is a rare X-linked recessive disease process caused by mutations in the TAZ gene. The TAZ gene codes for tafazzin which alters cardiolipin in mitochondria. Characteristic facies can be seen especially in infancy including a tall and broad forehead, prominent chin and full cheeks, larger ears, and deep-set eyes. Most patients present at birth or soon afterwards but some may not until later in life. Life expectancy is reduced with many childr...
Source: PediatricEducation.org - February 25, 2019 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Quality of Life Poor in Scleroderma
(MedPage Today) -- Worse than in rheumatoid arthritis or lupus (Source: MedPage Today Primary Care)
Source: MedPage Today Primary Care - February 20, 2019 Category: Primary Care Source Type: news

Gut Microbes May Help Drive Lupus, Study Finds
Comparing gut bacteria from lupus patients with bacteria from their healthy peers, scientists learned those with lupus had about five times more of the bacteria known as Ruminococcus gnavus. (Source: WebMD Health)
Source: WebMD Health - February 20, 2019 Category: Consumer Health News Source Type: news

Altered Gut Microbiome Seen in Patients With Active Lupus
WEDNESDAY, Feb. 20, 2019 -- The microbiome of patients with systemic lupus erythematosus (SLE), particularly those with increased disease activity, has reduced taxonomic complexity, according to a study published online Feb. 19 in the Annals of the... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - February 20, 2019 Category: Pharmaceuticals Source Type: news

Gut Microbes May Help Drive Lupus, Study Finds
WEDNESDAY, Feb. 20, 2019 -- An imbalance in the gut " microbiome " of people with lupus may be driving the chronic autoimmune disease as well as its flare-ups, new research suggests. The microbiome is the trillions of helpful bacteria that coexist in... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - February 20, 2019 Category: General Medicine Source Type: news

Gut Microbes May Help Drive Lupus, Study Finds
Title: Gut Microbes May Help Drive Lupus, Study FindsCategory: Health NewsCreated: 2/20/2019 12:00:00 AMLast Editorial Review: 2/20/2019 12:00:00 AM (Source: MedicineNet Arthritis General)
Source: MedicineNet Arthritis General - February 20, 2019 Category: Rheumatology Source Type: news

Gut microbiome imbalances may help diagnose, track lupus
Scientists have pinpointed gut bacteria that may cause painful flareups in people with Lupus, and this discovery that could lead to finding a better treatment for the condition, a new study says. (Source: Health News - UPI.com)
Source: Health News - UPI.com - February 19, 2019 Category: Consumer Health News Source Type: news

Lupus strongly linked to imbalances in gut microbiome
(NYU Langone Health / NYU School of Medicine) The disease systemic lupus erythematosus (SLE) -- marked by the attack on joints, skin, and kidneys by the body's immune system -- is linked to an abnormal mix of bacteria in the gut. This is according to a new study led by scientists at NYU School of Medicine. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - February 19, 2019 Category: Biology Source Type: news

IFM Therapeutics launches new spinout aimed at Parkinson's, lupus and other diseases
Boston biotech IFM Therapeutic LLC is taking a second major step out from drug giant Bristol-Myers Squibb's wake this week, spinning out its second subsidiary focused on developing treatments for autoimmune and central nervous system diseases. IFM Due (pronounced du-way) was launched Feb. 11 by the team behind IFM Therapeutics, which Bristol-Myers Squibb (NYSE: BMY) purchased in 2017 for $300 million upfront and upwards of $2 billion in milestone payments. Expanding on its founders' efforts at… (Source: bizjournals.com Health Care:Physician Practices headlines)
Source: bizjournals.com Health Care:Physician Practices headlines - February 11, 2019 Category: American Health Authors: Allison DeAngelis Source Type: news

Pulmonary Disease Rates High in Lupus
(MedPage Today) -- Interstitial lung disease most common among incident, prevalent cases (Source: MedPage Today Primary Care)
Source: MedPage Today Primary Care - February 8, 2019 Category: Primary Care Source Type: news

Nephrotic Syndrome: A Hindrance to Lupus Treatment?
(MedPage Today) -- In patients with lupus nephritis, lower renal response seen at 1 year (Source: MedPage Today Primary Care)
Source: MedPage Today Primary Care - February 6, 2019 Category: Primary Care Source Type: news

OU researcher developing new approach for early intervention of lupus
(University of Oklahoma) A University of Oklahoma researcher, Si Wu, and collaborators from the Oklahoma Medical Research Foundation and Indiana University, are developing new strategies leading to diagnosis and early intervention of lupus, an autoimmune disease that may affect up to 1.5 million Americans. The National Institutes of Health is funding the OU research with a $2 million grant over a five-year period. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 1, 2019 Category: International Medicine & Public Health Source Type: news

Are Mushrooms Healthy? Here ’s What Experts Say
The versatile mushroom comes in all different shapes, sizes and colors; it stands up as a side and can replace meat as a main. The fungus is a favorite of nutrition professionals — packed with vitamins, minerals and other nutrients. Here’s what mushrooms can do for your health, and how to work them into your diet. What are the nutritional benefits of mushrooms? Mushrooms are a low-carb, practically no-fat food with some protein. One serving is about a cup raw (a fist-sized amount) or 1/2 cup cooked. Though they’re small and light in calories—one serving only has about 15—they’re mighty i...
Source: TIME: Health - January 31, 2019 Category: Consumer Health News Authors: Cassie Shortsleeve  Tags: Uncategorized Diet/Nutrition Source Type: news

Kidney Transplant Boosts Survival in Lupus Nephritis Kidney Transplant Boosts Survival in Lupus Nephritis
Kidney transplantation is associated with a survival benefit for patients with lupus nephritis and end-stage renal disease (LN-ESRD), researchers have found.Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - January 23, 2019 Category: Consumer Health News Tags: Medscape Today News Source Type: news

Renal Transplant Improves Survival in ESRD Due to Lupus
WEDNESDAY, Jan. 23, 2019 -- For patients with end-stage renal disease (ESRD) due to lupus nephritis (LN), renal transplant is associated with a survival benefit, according to a study published online Jan. 22 in the Annals of Internal Medicine. April... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - January 23, 2019 Category: Pharmaceuticals Source Type: news

In 2019, What Are the Major Challenges in Lupus?
(MedPage Today) -- French experts call for new assessment tools and better use of available treatments (Source: MedPage Today Primary Care)
Source: MedPage Today Primary Care - January 21, 2019 Category: Primary Care Source Type: news

Fatigue in SLE: Mitochondrial, Not Structural?
(MedPage Today) -- MRI study rules out one explanation for lupus patients'tiredness (Source: MedPage Today Primary Care)
Source: MedPage Today Primary Care - January 16, 2019 Category: Primary Care Source Type: news

Lupus Research Alliance announces research grants to speed new lupus treatment
(Lupus Research Alliance) With the latest round of our Target Identification in Lupus (TIL) grants, seven outstanding scientists will receive the funds they need for research projects designed to test promising strategies for treating lupus. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 11, 2019 Category: International Medicine & Public Health Source Type: news

UCLA researchers correct genetic mutation that causes IPEX, a life-threatening autoimmune syndrome
UCLA researchers led by Dr. Donald Kohn have created a method for modifying blood stem cells to reverse the genetic mutation that causes a life-threatening autoimmune syndrome called IPEX. The gene therapy, which was tested in mice, is similar to the technique Kohn has used to cure patients with another immune disease, severe combined immune deficiency, or SCID, also known as bubble baby disease.The workis described in a study published in the journal Cell Stem Cell.IPEX is caused by a mutation that prevents a gene called FoxP3 from making a protein needed for blood stem cells to produce immune cells called regulatory T ce...
Source: UCLA Newsroom: Health Sciences - January 10, 2019 Category: Universities & Medical Training Source Type: news

IgE: A Novel Target in Lupus?
(MedPage Today) -- Asthma drug showed preliminary promise as add-on therapy (Source: MedPage Today Primary Care)
Source: MedPage Today Primary Care - January 10, 2019 Category: Primary Care Source Type: news

Munchausen by proxy syndrome mimicking childhood-onset systemic lupus erythematosus - Kuhne ACA, Pitta AC, Galassi SC, Gon çalves AMF, Cardoso ACA, Paz JA, Campos LMA, Silva CA.
Childhood-onset systemic lupus erythematosus (cSLE) is a chronic inflammatory multisystem autoimmune disease that requires multiple differential diagnoses. Munchausen by proxy syndrome (MBPS) is a form of child abuse, where a caregiver intentionally create... (Source: SafetyLit)
Source: SafetyLit - January 10, 2019 Category: International Medicine & Public Health Tags: Age: Infants and Children Source Type: news

Systemic Lupus Erythematosus | Medscape Systemic Lupus Erythematosus | Medscape
Review in-depth clinical information, latest medical news, and guidelines on lupus, systemic lupus erythematosus (SLE). Recognize lupus symptoms and signs of lupus. Review articles on the optimal lupus treatment. (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - January 4, 2019 Category: Consumer Health News Tags: Resource Center Source Type: news

10 Top Questions You Had For Dr. Google In 2018
(CNN) — People were curious about the keto diet, ALS and endometriosis in 2018. Those are just a few of the health-related topics that had Internet surfers in the United States turning to Dr. Google with questions this year, according to a top 10 list from the search engine giant. The data, based on search terms, was collected from January to mid-December. Last year, some of the top health-related questions searched on Google included what causes hiccups, how to stop snoring, how long flu lasts and what is lupus. Some of the top health-related questions on Google in 2016 were related to Zika, traumatic brain injuries...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - December 21, 2018 Category: Consumer Health News Authors: Health – CBS Boston Tags: Health News Offbeat Google Local TV Source Type: news

Yale-led team examines impact of diet intervention on autoimmunity in mice
A new Yale-led study suggests that a change in diet — specifically adding more fiber — could be beneficial to people with autoimmune diseases such as lupus. (Source: Yale Science and Health News)
Source: Yale Science and Health News - December 20, 2018 Category: Universities & Medical Training Source Type: news

Yale-led team examines impact of diet intervention on autoimmunity in mice
(Yale University) Could a change in diet be beneficial to people with autoimmune diseases such as lupus? A Yale-led team of researchers have revealed how a dietary intervention can help prevent the development of this autoimmune disease in susceptible mice. The study was published in Cell Host& Microbe. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - December 20, 2018 Category: International Medicine & Public Health Source Type: news

Two outstanding scientists recognized for transformative Lupus research projects
(Lupus Research Alliance) The Lupus Research Alliance is proud to announce the 2018 recipients of the Dr. William E. Paul Distinguished Innovator Awards in Lupus and Autoimmunity: Nir Hacohen, PhD and Vijay Kuchroo, DVM, PhD. Dr. Hacohen is seeking better ways to treat lupus kidney disease, the major cause of illness and death among patients with lupus. Dr. Kuchroo is looking at ways to harness regulatory T and B cells as a new approach to lupus treatment. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - December 20, 2018 Category: International Medicine & Public Health Source Type: news

FDA Grants Fast Track Designation to the Baricitinib Development Program for the Treatment of Systemic Lupus Erythematosus (SLE)
INDIANAPOLIS, Dec. 13, 2018 -- (Healthcare Sales & Marketing Network) -- Eli Lilly and Company (NYSE: LLY) and Incyte Corporation (NASDAQ: INCY) announced today that the U.S. Food and Drug Administration (FDA) has granted Fast Track designation to baricit... Biopharmaceuticals, FDA Eli Lilly, Baricitinib, Systemic Lupus Erythematosus (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - December 13, 2018 Category: Pharmaceuticals Source Type: news

Lupus Significantly Elevates Risk of 16 Cancer Types (CME/CE)
(MedPage Today) -- Overall risks increased for both women and men, in particular in lymphatic and blood cancers, among others. (Source: MedPage Today Hematology/Oncology)
Source: MedPage Today Hematology/Oncology - December 11, 2018 Category: Hematology Source Type: news

Diagnosing Early Lupus from Mimics
(MedPage Today) -- Certain clinical features may distinguish early SLE from other conditions (Source: MedPage Today Primary Care)
Source: MedPage Today Primary Care - December 8, 2018 Category: Primary Care Source Type: news

In Lupus, Risks for Cancers Rise
(MedPage Today) -- Overall risks increased for both women and men (Source: MedPage Today Hematology/Oncology)
Source: MedPage Today Hematology/Oncology - December 7, 2018 Category: Hematology Source Type: news

Questions Persist About CVD Risk and Stratification in Lupus (CME/CE)
(MedPage Today) -- Risk of cardiovascular events was seven-fold higher than in patients without lupus (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - November 29, 2018 Category: Cardiology Source Type: news

Medical News Today: What is the difference between MS and lupus?
Multiple sclerosis and lupus both involve the immune system, but they cause different symptoms. In this article, learn about the differences and how a doctor makes a diagnosis. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 29, 2018 Category: Consumer Health News Tags: Multiple Sclerosis Source Type: news

Voclosporin Effective in Lupus Nephritis
(MedPage Today) -- Results from AURA-LV trial in patients with active disease (Source: MedPage Today Primary Care)
Source: MedPage Today Primary Care - November 24, 2018 Category: Primary Care Source Type: news

Pregnancy joy for lupus sufferer, 29, who was told she could never carry children
At just 20 years old, then-law student Paula Birch Bilingsley was told she had less than 10 years to live and was infertile. Ten years later, she is healthy, thriving, and has two children. (Source: the Mail online | Health)
Source: the Mail online | Health - November 23, 2018 Category: Consumer Health News Source Type: news

Questions on CV Risk Persist in Lupus
(MedPage Today) -- Risk of cardiovascular events was sevenfold higher than expected (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - November 20, 2018 Category: Cardiology Source Type: news

Medical News Today: What is lupus?
Lupus is a complex and potentially serious autoimmune condition. It has a variety of symptoms and can affect different parts of the body. It is difficult to diagnose, but new scientific discoveries are making early diagnosis easier. Treatment can provide effective ways to manage symptoms and improve quality of life. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 16, 2018 Category: Consumer Health News Tags: Lupus Source Type: news

Medical News Today: Treating and managing lupus and preventing flares
Lupus has a wide variety of effects and symptoms and it can affect the whole body. A person may need a variety of medications and other treatments to control symptoms and manage the condition. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 16, 2018 Category: Consumer Health News Tags: Lupus Source Type: news

From the ashes of a failed pain drug, a new therapeutic path emerges
(Boston Children's Hospital) A surprising discovery about a failed pain drug -- and specifically, the pathway it targets, BH4 -- could have implications for autoimmunity and cancer. Neuroscientists at Boston Children's Hospital and immunologists from IMBA in Vienna report that BH4 also functions as a kind of immunological thermostat, raising and lowering the activity levels of T cells. Inhibiting BH4 could relieve atopic dermatitis, psoriasis, lupus, polyarthritis and inflammatory bowel disease; boosting it could help the immune system attack cancers. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - November 16, 2018 Category: Cancer & Oncology Source Type: news

What Causes Post-Inflammatory Hypopigmentation?
Discussion Hypopigmentation can be worrisome for many families because of cosmesis and the worry that “something is wrong.” The normal natural changes in skin-tone over the year due to different light exposure and wide variations within individuals is not something that many people are aware of. Post-inflammatory hypopigmentation is a common cause of hypopigmentation. Vitiligo is the most common cause of depigmentation. Vitiligo is an acquired, depigmenting disorder with typical lesions appearing as milky white macules with distinct margins that are not scaly. Hair (including eyebrows and eyelashes) can be dep...
Source: PediatricEducation.org - November 12, 2018 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Link between autoimmune, heart disease explained in mice
(Washington University School of Medicine) Autoimmune diseases such as psoriasis, lupus and rheumatoid arthritis more than double the risk of cardiovascular disease. A new study shows that immune cells that arise during autoimmune disease cause cholesterol to become trapped inside blood vessels. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 8, 2018 Category: International Medicine & Public Health Source Type: news

An autoimmune disease variant of IgG1 modulates B cell activation and differentiation
The maintenance of autoreactive B cells in a quiescent state is crucial for preventing autoimmunity. Here we identify a variant of human immunoglobulin G1 (IgG1) with a Gly396->Arg substitution (hIgG1-G396R), which positively correlates with systemic lupus erythematosus. In induced lupus models, murine homolog Gly390->Arg (G390R) knockin mice generate excessive numbers of plasma cells, leading to a burst of broad-spectrum autoantibodies. This enhanced production of antibodies is also observed in hapten-immunized G390R mice, as well as in influenza-vaccinated human G396R homozygous carriers. This variant potentiates t...
Source: ScienceNOW - November 8, 2018 Category: Science Authors: Chen, X., Sun, X., Yang, W., Yang, B., Zhao, X., Chen, S., He, L., Chen, H., Yang, C., Xiao, L., Chang, Z., Guo, J., He, J., Zhang, F., Zheng, F., Hu, Z., Yang, Z., Lou, J., Zheng, W., Qi, H., Xu, C., Zhang, H., Shan, H., Zhou, X.-j., Wang, Q., Shi, Y., L Tags: Immunology, Medicine, Diseases reports Source Type: news