Thalidomide and Lenalidomide for Refractory SLE/CLE Thalidomide and Lenalidomide for Refractory SLE/CLE
What do we currently know about the safety and efficacy of these drug options for the treatment of refractory systemic/cutaneous lupus erythematosus?Journal of Clinical Rheumatology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - September 15, 2021 Category: Consumer Health News Tags: Rheumatology Journal Article Source Type: news

What Are the Advantages and Disadvantages of Different Renal Replacement Therapies?
Discussion Kidneys are amazing in that they filter the blood, eliminate toxins, balance fluids and electrolytes plus have a lot of reserve to do the job they need to do even when injured. Therefore, depending on the problem, chronic renal disease (CRD) often allows time before renal replacement therapy (RRT) is needed. RRT currently is dialysis (peritoneal or hemodialysis) or renal transplant. In general, the patient’s own kidneys do the best job for them but there is always a balance between the problems of CRD and its management, versus the potentially improved renal function with RRT. RRT itself though has a diffe...
Source: PediatricEducation.org - September 13, 2021 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

FDA Clears Thermo Scientific EliA SmD(P)-S Test For Use In U.S.
New blood test is designed to reduce the number of false positive results and provide improved diagnostic guidance in Systemic Lupus Erythematosus PORTAGE, Mich., Aug. 26, 2021 -- (Healthcare Sales & Marketing Network) -- Thermo Scientific EliA SmDP-S ... Diagnostics, FDA Thermo Fisher Scientific, EliA SmDP-S, Systemic Lupus Erythematosus (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - August 26, 2021 Category: Pharmaceuticals Source Type: news

Experts Debate Merits of Dual Therapy for Lupus Nephritis Experts Debate Merits of Dual Therapy for Lupus Nephritis
Brad Rovin, MD, and Richard Furie, MD, discussed the merits of dual therapy with voclosporin or belimumab in lupus nephritis but said response rates leave a lot of room for improvement.Medscape Medical News (Source: Medscape Pharmacist Headlines)
Source: Medscape Pharmacist Headlines - August 19, 2021 Category: Drugs & Pharmacology Tags: Rheumatology News Source Type: news

CAR T-Cell Therapy Drives Refractory SLE Into Remission CAR T-Cell Therapy Drives Refractory SLE Into Remission
B-cell depletion with chimeric antigen receptor T cells induced both serologic and clinical remissions in a patient with treatment-resistant lupus.Medscape Medical News (Source: Medscape Dermatology Headlines)
Source: Medscape Dermatology Headlines - August 13, 2021 Category: Dermatology Tags: Rheumatology News Source Type: news

COVID-19 Booster Shots Are Still Controversial —Even for the Immunocompromised People Who Likely Need Them the Most
Chris Neblett, 44, was among the first people in the U.S. to get vaccinated against COVID-19. His job with the U.S. State Department allowed him to get his initial dose of Pfizer-BioNTech’s vaccine in late December 2020. By January 2021, he was fully vaccinated. But that didn’t mean he was fully protected. Neblett, who received a kidney transplant in 2018 and still takes immune-system-suppressing drugs to prevent his body from rejecting the organ, found out through his participation in a Johns Hopkins study of vaccination among transplant patients that he didn’t produce any disease-fighting antibodies, ev...
Source: TIME: Health - August 11, 2021 Category: Consumer Health News Authors: Jamie Ducharme Tags: Uncategorized COVID-19 Source Type: news

CAR T-Cell Immunotherapy Rids Woman of Tough-to-Treat Lupus
Title: CAR T-Cell Immunotherapy Rids Woman of Tough-to-Treat LupusCategory: Health NewsCreated: 8/5/2021 12:00:00 AMLast Editorial Review: 8/6/2021 12:00:00 AM (Source: MedicineNet Arthritis General)
Source: MedicineNet Arthritis General - August 6, 2021 Category: Rheumatology Source Type: news

CAR T-Cell Immunotherapy Rids Woman of Tough-to-Treat Lupus
Researchers have used genetically tweaked immune system cells to send a woman's severe lupus into remission. (Source: WebMD Health)
Source: WebMD Health - August 5, 2021 Category: Consumer Health News Source Type: news

CAR T-Cell Immunotherapy Rids Woman of Tough-to-Treat Lupus
THURSDAY, Aug. 5, 2021 -- In a first, researchers have used genetically tweaked immune system cells to send a woman's severe lupus into remission. The treatment -- called CAR T-cell therapy -- is already approved in the United States for fighting... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - August 5, 2021 Category: General Medicine Source Type: news

Arthritis, lupus flares rare after COVID-19 vaccination, study finds
The COVID-19 vaccine rarely causes flares in people with rheumatoid arthritis and lupus, according to a study published Wednesday by the journal Arthritis and Rheumatology. (Source: Health News - UPI.com)
Source: Health News - UPI.com - August 4, 2021 Category: Consumer Health News Source Type: news

FDA Approves Anifrolumab (Saphnelo) as New Lupus Treatment FDA Approves Anifrolumab (Saphnelo) as New Lupus Treatment
Anifrolumab, a monoclonal antibody against type 1 interferon receptor, improved overall disease activity in patients with SLE on standard therapy, according to data from three trials.FDA Approvals (Source: Medscape Dermatology Headlines)
Source: Medscape Dermatology Headlines - August 2, 2021 Category: Dermatology Tags: Rheumatology News Alert Source Type: news

FDA Approves Saphnelo (anifrolumab) for Moderate to Severe Systemic Lupus Erythematosus
2 August 2021 -- AstraZeneca’s Saphnelo (anifrolumab-fnia) has been approved in the US for the treatment of adult patients with moderate to severe systemic lupus erythematosus (SLE) who are receiving standard therapy.1 The approval by the... (Source: Drugs.com - New Drug Approvals)
Source: Drugs.com - New Drug Approvals - August 2, 2021 Category: Drugs & Pharmacology Source Type: news

COVID Vax Does Not Increase Risk of Flare in Patients With Lupus COVID Vax Does Not Increase Risk of Flare in Patients With Lupus
An international web-based survey found a very low rate of medically confirmed flare post COVID vaccination in nearly 700 participants.Medscape Medical News (Source: Medscape Dermatology Headlines)
Source: Medscape Dermatology Headlines - July 28, 2021 Category: Dermatology Tags: Rheumatology News Source Type: news

Fifteen years in the making, biotech lands in Bay Area with fresh funding from Hyatt heirs and plan to change direction of inflammatory diseases
Giant drug maker Bristol-Myers Squibb and a string of investment vehicles led by heirs of the Hyatt Hotels fortune invested in a North Bay company tapping deep patient data to move faster to discover and develop drugs against lupus, Crohn's disease and other inflammatory diseases. (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - July 27, 2021 Category: Biotechnology Authors: Ron Leuty Source Type: news

SLE Neuropsych Event Etiology Helps Define Predictors, Outcomes SLE Neuropsych Event Etiology Helps Define Predictors, Outcomes
Male sex, active systemic lupus erythematosus, and corticosteroid use were among the factors positively associated with neuropsychiatric events in patients with SLE.Medscape Medical News (Source: Medscape Dermatology Headlines)
Source: Medscape Dermatology Headlines - July 10, 2021 Category: Dermatology Tags: Rheumatology News Source Type: news

NYUAD study maps nanobody structure, leading to new ways to potentially fight diseases
(New York University) For the first time in the UAE, researchers at NYU Abu Dhabi have used nuclear magnetic resonance techniques to determine the structure of a specific nanobody, Nb23, potentially leading to a better understanding of how this small protein derived from an antibody type, found only in camelids (i.e camels, llamas, and alpacas) and sharks, can fight diseases ranging from rheumatoid arthritis, lupus and psoriasis to lymphoma and breast cancer. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - July 2, 2021 Category: Cancer & Oncology Source Type: news

NIDCR's Summer 2021 E-Newsletter
Having trouble viewing this email? View it as a Web page. NIDCR's Summer 2021 E-Newsletter In this issue: NIDCR News Funding Opportunities & Related Notices NIH/HHS News Subscribe to NICDR News Science Advances   Grantee News   NIDCR News NIDCR to Release Report on Oral Health in America As a 20-year follow-up to the seminal Oral Health in America: A Report of the Surgeon General, NIDCR will release Oral Health in America: Advances and Challenges in the fall of 2021. The report will illuminate new directions...
Source: NIDCR Science News - July 1, 2021 Category: Dentistry Source Type: news

Accelerating Lupus Drug Discovery & Development: Fireside Chat...
This webinar will feature a discussion of advancements and critical milestones to date in SLE research and drug discovery. It will explore key considerations for improving both research into SLE, as...(PRWeb June 28, 2021)Read the full story at https://www.prweb.com/releases/accelerating_lupus_drug_discovery_development_fireside_chat_with_experts_in_sle_research_upcoming_webinar_hosted_by_xtalks/prweb18034256.htm (Source: PRWeb: Medical Pharmaceuticals)
Source: PRWeb: Medical Pharmaceuticals - June 28, 2021 Category: Pharmaceuticals Source Type: news

Lupus Images Fall Short in Diversity Lupus Images Fall Short in Diversity
Medical resources in general have historically underrepresented patients of color.Medscape Medical News (Source: Medscape Dermatology Headlines)
Source: Medscape Dermatology Headlines - June 18, 2021 Category: Dermatology Tags: Dermatology News Source Type: news

Dacrocystitis in a Teenager?
Discussion Tears are produced in the lacrimal gland which resides in the upper outer quadrant of the eye. The tears flow across the eye medially and are collected in the superior and inferior puncta which drain into their respective canaliculi, and these drain into a common canaliculus. Tears then pass through the valve of Rosenmuler into the lacrimal sac where they are collected. Tears then pass through the nasolacrimal duct, through the distal valve of Hasner and into the nasal cavity. Vascular connections are extensive in this anatomic area and veins do not have valves. Therefore infections can spread easily through dir...
Source: PediatricEducation.org - June 14, 2021 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

BEAT-LUPUS: Belimumab After Rituximab Delays Severe Flares BEAT-LUPUS: Belimumab After Rituximab Delays Severe Flares
Results from a phase 2b trial are"clearly encouraging" and"support the hypothesis that BAFF [B-cell-activating factor] can drive flares after rituximab," said Michael Ehrenstein, MD.Medscape Medical News (Source: Medscape Dermatology Headlines)
Source: Medscape Dermatology Headlines - June 4, 2021 Category: Dermatology Tags: Rheumatology News Source Type: news

Add-On Voclosporin Improves Outcome in Lupus Nephritis Add-On Voclosporin Improves Outcome in Lupus Nephritis
Voclosporin plus MMF and low-dose corticosteroids improves renal response rates compared with use of these agents alone in patients with in lupus nephritis, according to a company-funded study.Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - June 1, 2021 Category: Consumer Health News Tags: Nephrology News Source Type: news

Experimental Treatment Offers New Hope Against Lupus
Title: Experimental Treatment Offers New Hope Against LupusCategory: Health NewsCreated: 5/27/2021 12:00:00 AMLast Editorial Review: 5/28/2021 12:00:00 AM (Source: MedicineNet Arthritis General)
Source: MedicineNet Arthritis General - May 28, 2021 Category: Rheumatology Source Type: news

Rheumatoid arthritis and systemic lupus erythematosus during COVID-19 quarantine period
This study aimed to investigate self-reported symptoms of disease flares among patients with rheumatoid arthritis or systemic lupus erythematosus during the COVID-19 pandemic. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 28, 2021 Category: International Medicine & Public Health Source Type: news

Experimental Treatment Offers New Hope Against Lupus
A small, early "phase 1" trial finds an experimental antibody therapy may help ease skin symptoms from the autoimmune disease lupus. (Source: WebMD Health)
Source: WebMD Health - May 27, 2021 Category: Consumer Health News Source Type: news

Experimental Treatment Offers New Hope Against Lupus
THURSDAY, May 27, 2021 -- An experimental antibody therapy may help ease skin symptoms from the autoimmune disease lupus, a small preliminary trial suggests. Researchers found that a higher-dose version of the drug spurred a " clinically meaningful " ... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - May 27, 2021 Category: General Medicine Source Type: news

Biotech firm Asylia Therapeutics raises $14.5M, names founding CEO
Houston-based biotechnology firm Asylia Therapeutics Inc. raised $14.5 million to advance its clinical trials for cancer drugs. The Series A round was led by Houston-based Sporos Bioventures, Asylia announced May 25. The company will use proceeds to bring Asylia's assets to first-in-human clinical trials for oncology. Asylia could potentially generate proof-of-concept signals for its clinical assets in treating autoimmune diseases like lupus, the firm said. "While cancer research has come a significant… (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - May 25, 2021 Category: Biotechnology Authors: Chris Mathews Source Type: news

Rogue antibodies wreak havoc in severe COVID-19 cases
The development of antibodies to the COVID-19 virus has been the great long-term hope of ending the pandemic. However, immune system turncoats are also major culprits in severe cases of COVID-19, Yale scientists report in the journal Nature. These autoantibodies target and react with a person's tissues or organs similar to ones that cause autoimmune diseases such as lupus or rheumatoid arthritis. (Source: World Pharma News)
Source: World Pharma News - May 19, 2021 Category: Pharmaceuticals Tags: Featured Research Research and Development Source Type: news

How Is Lupus Nephritis Treated
? (Source: eMedicineHealth.com)
Source: eMedicineHealth.com - May 12, 2021 Category: General Medicine Source Type: news

Vaccination Rates Low Among Lupus Patients on Medicaid
TUESDAY, May 11, 2021 -- Medicaid beneficiaries with systemic lupus erythematosus (SLE) who are not vaccinated are at risk for potentially avoidable acute care use for vaccine-preventable illnesses, according to a study published online May 4 in... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - May 11, 2021 Category: Pharmaceuticals Source Type: news

What Are The Six Classes of Lupus Nephritis
? (Source: eMedicineHealth.com)
Source: eMedicineHealth.com - May 7, 2021 Category: General Medicine Source Type: news

Arthritis: The best type of diet to ease inflammation in the body – what to eat
ARTHRITIS caused by misdirected inflammation include rheumatoid, psoriatic, systemic lupus erythematosus, gout and ankylosing spondylitis. Could an anti-inflammatory diet help ease symptoms? (Source: Daily Express - Health)
Source: Daily Express - Health - May 6, 2021 Category: Consumer Health News Source Type: news

Study uncovers potentially avoidable acute care use for vaccine-preventable illnesses in lupus patients
(Wiley) A new study published in Arthritis Care& Research indicates that few individuals with the autoimmune disease lupus who were publicly insured through Medicaid received recommended vaccines in 2000-2010. Also, those who were unvaccinated needed more acute care for vaccine-preventable illnesses. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 5, 2021 Category: International Medicine & Public Health Source Type: news

Rituximab Benefits Seen in Neuropsychiatric Lupus Rituximab Benefits Seen in Neuropsychiatric Lupus
Additionally, the use of concomitant cyclophosphamide might enhance the level of improvement seen in some patients, said Dr Trixy David in presenting data at the British Society for Rheumatology meeting.Medscape Medical News (Source: Medscape Rheumatology Headlines)
Source: Medscape Rheumatology Headlines - April 30, 2021 Category: Rheumatology Tags: Rheumatology News Source Type: news

B Cells in Relapsing Lupus Nephritis and Cutaneous Vasculitis B Cells in Relapsing Lupus Nephritis and Cutaneous Vasculitis
A case of a woman with systemic lupus erythematosus whose nephritis and cutaneous vasculitis were refractory to treatment.HSS Grand Rounds Complex Cases (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - April 28, 2021 Category: Consumer Health News Tags: Rheumatology Clinical Case Source Type: news

Physical activity reduces cardiovascular risk in rheumatic patients
(Funda ç ã o de Amparo à Pesquisa do Estado de S ã o Paulo) People with diseases such as rheumatoid arthritis and lupus are more likely to have heart attacks, angina, and strokes. A review of the scientific literature on the subject shows that regular exercise improves vascular function in these patients (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 27, 2021 Category: International Medicine & Public Health Source Type: news

Patient Benefits Justify Price of New Lupus Nephritis Drugs Patient Benefits Justify Price of New Lupus Nephritis Drugs
Prices of two new drugs approved by the FDA for lupus nephritis are in reasonable alignment with their estimated benefits for patients with the disease, a report indicates.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - April 26, 2021 Category: Consumer Health News Tags: Nephrology News Source Type: news

NIH Awards BellBrook Labs Phase II Grant to Develop Drugs Targeting the cGAS-STING Pathway for Lupus and Related Autoimmune Diseases
The National Institute of Allergy and Infectious Diseases (NIAID) recently awarded BellBrook Labs a $1.8 million Phase II Small Business Innovative Research (SBIR) grant to develop small molecule... (Source: The Scientist)
Source: The Scientist - April 22, 2021 Category: Science Tags: The Scientist The Marketplace Source Type: news

Quinacrine: Au Revoir or Adieu? Quinacrine: Au Revoir or Adieu?
Quinacrine is a safe and effective antimalarial agent. Does it have a place in the treatment of lupus?Current Opinion in Rheumatology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - April 20, 2021 Category: Consumer Health News Tags: Rheumatology Journal Article Source Type: news

Renal, CV Damage May Develop in Mild SLE Despite Treatment Renal, CV Damage May Develop in Mild SLE Despite Treatment
An increase in disease activity in systemic lupus erythematosus is associated with significant increases in the risk of renal and cardiovascular damage.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - April 16, 2021 Category: Consumer Health News Tags: Rheumatology News Source Type: news

NIDCR's Spring 2021 E-Newsletter
Having trouble viewing this email? View it as a Web page. NIDCR's Spring 2021 E-Newsletter In this issue: NIDCR News Funding Opportunities & Related Notices NIH/HHS News Subscribe to NICDR News Science Advances   Grantee News   NIDCR News NIDCR & NIH Stand Against Structural Racism NIDCR Director Rena D’Souza, DDS, MS, PhD, said in a statement that there is no place for structural racism in biomedical research, echoing remarks from NIH Director Francis Collins, MD, PhD, in his announcement of a new NIH ...
Source: NIDCR Science News - April 7, 2021 Category: Dentistry Source Type: news

Masonic Medical Research Institute awarded Department of Defense Lupus Impact Award
(Masonic Medical Research Institute) Lupus is a common and devastating autoimmune disease that has no cure and current treatments only work to improve symptoms, which often have secondary, even devastating, side effects. Therefore, there is significant need and urgency to identify more specific and targeted therapies for this disease. Dr. Maria Kontaridis, Executive Director at MMRI aims to try to do just this, with grant support from a newly garnered Department of Defense (DOD) Lupus Impact Award, totaling $750,000. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - April 2, 2021 Category: International Medicine & Public Health Source Type: news

Helping childhood-onset lupus patients stay healthy as adults
(UT Southwestern Medical Center) DALLAS - March 30, 2021 - UT Southwestern researchers have identified factors that put patients with childhood-onset lupus at elevated risk for poor outcomes, such as end-stage renal disease or death, as they transition from pediatric to adult health care. The findings, published online in Seminars in Arthritis and Rheumatism, emphasize the precarious nature of this period and shine a spotlight on areas prime for intervention to help protect these vulnerable patients. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 30, 2021 Category: International Medicine & Public Health Source Type: news

Vitamin D deficiency linked to metabolic changes in patients with lupus - study
(University of Birmingham) Patients with lupus are more likely to have metabolic syndrome and insulin resistance - both factors linked to heart disease - if they have lower vitamin D levels, a new study reveals. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 26, 2021 Category: International Medicine & Public Health Source Type: news

Research group identifies potential therapeutic target for lupus
(Michigan Medicine - University of Michigan) Inhibiting IRE1α, a molecule activated by the endoplasmic reticulum in neutrophils, counters disease progression in lupus mice. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 26, 2021 Category: International Medicine & Public Health Source Type: news

COVID-19's Impact on Lupus Inpatients Examined in Study COVID-19's Impact on Lupus Inpatients Examined in Study
' Recently, anti-interferon antibodies have been implicated in severe SARS-CoV-2 infection while it has been known for decades that patients with SLE may produce such autoantibodies. 'Medscape Medical News (Source: Medscape Infectious Diseases Headlines)
Source: Medscape Infectious Diseases Headlines - March 25, 2021 Category: Infectious Diseases Tags: Rheumatology News Source Type: news

Lupus Research Alliance announces awards aimed at new lupus treatments
(Lupus Research Alliance) The Lupus Research Alliance proudly announces two exceptional recipients of the 2020 Dr. William E. Paul Distinguished Innovator Award in Lupus and Autoimmunity: Jacques Banchereau, PhD and Ignacio Sanz, MD. Both projects funded by this grant are investigating different mechanisms altered in lupus patients that induce an autoimmune response. Their findings could lead to the development of more precise treatments to prevent lupus onset or progression. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 25, 2021 Category: International Medicine & Public Health Source Type: news

Yes or No: The Future of Rheumatology Is Sub-Subspecialization Yes or No: The Future of Rheumatology Is Sub-Subspecialization
It makes little sense for some rheumatologists to declare they're only going to see patients with psoriatic arthritis, or gout, or lupus.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - March 16, 2021 Category: Consumer Health News Tags: Rheumatology News Source Type: news

January-February 2021 RefSeq annotations include dog, fly, rat
This January and February, the NCBI Eukaryotic Genome Annotation Pipeline released new annotations in RefSeq for the following organisms: Benincasa hispida (wax gourd) Canis lupus familiaris (dog) Corvus cornix cornix (hooded crow) Crotalus tigris (tiger rattlesnake) Culex pipiens pallens (northern house mosquito) Dioscorea cayenensis subsp. rotundata (Guinea yam) Drosophila santomea (fly) Drosophila simulans (fly) Drosophila … Continue reading January-February 2021 RefSeq annotations include dog, fly, rat → (Source: NCBI Insights)
Source: NCBI Insights - March 16, 2021 Category: Databases & Libraries Authors: NCBI Staff Tags: What's New Eukaryotic genome annotation RefSeq Source Type: news

Nearly 20% of Lupus Patients Have Severe Infection in First Decade After Diagnosis Nearly 20% of Lupus Patients Have Severe Infection in First Decade After Diagnosis
Infections remain a leading cause of morbidity and early mortality in patients with SLE, writes Kai Zhao, MSc, of Arthritis Research Canada, Richmond, and colleagues.Medscape Medical News (Source: Medscape Rheumatology Headlines)
Source: Medscape Rheumatology Headlines - March 12, 2021 Category: Rheumatology Tags: Rheumatology News Source Type: news