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NIH program to accelerate therapies for arthritis, lupus releases first datasets
(NIH/National Institute of Arthritis and Musculoskeletal and Skin Diseases) Datasets characterizing individual cells in rheumatoid arthritis and systemic lupus erythematosus disease tissue from the Accelerating Medicines Partnership for Rheumatoid Arthritis and Systemic Lupus Erythematosus (AMP RA/SLE) Phase I study are now available to the research community. Scientists from across the biomedical research community can access the AMP RA/SLE datasets to explore important research questions about these autoimmune conditions. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 21, 2018 Category: International Medicine & Public Health Source Type: news

Deconstructing lupus -- could some of its makeup be part of its cure?
(University of Houston) University of Houston biomedical engineer Chandra Mohan is examining the protein ALCALM to find a cure for lupus and its complications. ALCALM appears in patients that have kidney disease and lupus. Mohan says it's like finding a suspect at the scene of different crimes. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 20, 2018 Category: International Medicine & Public Health Source Type: news

NIH program to accelerate therapies for arthritis, lupus releases first datasets
Collaborative effort provides important clues about potential research targets. (Source: National Institutes of Health (NIH) News Releases)
Source: National Institutes of Health (NIH) News Releases - February 16, 2018 Category: American Health Source Type: news

Researchers discover the unexpected role of platelets in immune response
(Universit é Laval) Platelets play a much bigger role in our immune system than previously thought, according to Universit é Laval researchers. In addition to their role in coagulation and healing, platelets also act as the immune system's first responders when a virus, bacterium, or allergen enters the bloodstream. This discovery opens the door to new ways to treat patients with septic shock caused by viral or bacterial infection and people with auto-immune diseases like rheumatoid arthritis and lupus. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 1, 2018 Category: International Medicine & Public Health Source Type: news

The X chromosome link to lupus
(Source: ScienceNOW)
Source: ScienceNOW - February 1, 2018 Category: Science Authors: Balasubramani, A. Tags: twis Source Type: news

A drug to fight two lupus symptoms
(Source: ScienceNOW)
Source: ScienceNOW - January 25, 2018 Category: Science Authors: Wong, W. Tags: twis Source Type: news

Severe Inflammation Can Erupt in Childhood Lupus (CME/CE)
(MedPage Today) -- Almost 10% developed macrophage activation syndrome -- a cytokine storm (Source: MedPage Today Pediatrics)
Source: MedPage Today Pediatrics - January 23, 2018 Category: Pediatrics Source Type: news

Guanabenz inhibits TLR9 signaling through a pathway that is independent of eIF2{alpha} dephosphorylation by the GADD34/PP1c complex
Endoplasmic reticulum (ER) stress triggers or amplifies inflammatory signals and cytokine production in immune cells. Upon the resolution of ER stress, the inducible phosphatase 1 cofactor GADD34 promotes the dephosphorylation of the initiation factor eIF2α, thereby enabling protein translation to resume. Several aminoguanidine compounds, such as guanabenz, perturb the eIF2α phosphorylation-dephosphorylation cycle and protect different cell or tissue types from protein misfolding and degeneration. We investigated how pharmacological interference with the eIF2α pathway could be beneficial to treat autoinfl...
Source: Signal Transduction Knowledge Environment - January 23, 2018 Category: Science Authors: Perego, J., Mendes, A., Bourbon, C., Camosseto, V., Combes, A., Liu, H., Manh, T.-P. V., Dalet, A., Chasson, L., Spinelli, L., Bardin, N., Chiche, L., Santos, M. A. S., Gatti, E., Pierre, P. Tags: STKE Research Articles Source Type: news

Deteriorating Serology May Precede Delayed Lupus Nephritis (CME/CE)
(MedPage Today) -- DLN likely to become more common with rising life expectancy in SLE (Source: MedPage Today Rheumatology)
Source: MedPage Today Rheumatology - January 20, 2018 Category: Rheumatology Source Type: news

iMedicalApps: This Week's Best Apps
(MedPage Today) -- Lupus, pregnancy, and primary care apps all made the cut (Source: MedPage Today OB/GYN)
Source: MedPage Today OB/GYN - January 19, 2018 Category: OBGYN Source Type: news

Experts seek to standardize treatments for childhood rheumatic diseases
(Wiley) Pediatric rheumatic diseases are a varied group of rare diseases including juvenile forms of arthritis, lupus, fibromyalgia, and other conditions. Currently, there is considerable variability in how patients with these diseases are treated in clinical practice, making it difficult to understand which therapies work best. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 15, 2018 Category: International Medicine & Public Health Source Type: news

Stroke Risk Confirmed in SLE (CME/CE)
(MedPage Today) -- Cerebrovascular events occurred in 4.5% of lupus patients, most attributed to the disease (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - January 13, 2018 Category: Cardiology Source Type: news

6th World Congress on Controversies, Debates & Consensus in Bone, Muscle & Joint Diseases (BMJD)
The 6th BMJD Congress will address the most burning questions in the field of Rheumatoid Arthritis, Inflammatory Arthritis, Osteoarthritis, Spondyloarthropathy, Lupus, and more.  (Source: Orthogate - Latest News)
Source: Orthogate - Latest News - January 11, 2018 Category: Orthopaedics Tags: Featured Meetings Events Source Type: news

Efficacy Seen for Belimumab in Chinese Lupus (CME/CE)
(MedPage Today) -- Few had been included in earlier pivotal trials (Source: MedPage Today Primary Care)
Source: MedPage Today Primary Care - January 8, 2018 Category: Primary Care Source Type: news

Rituximab Effective for Lupus - Associated Cytopenia
Overall initial response rate of 86 percent in 71 patients, with complete response for 60.5 percent (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - December 27, 2017 Category: Cancer & Oncology Tags: Cardiology, Dermatology, Nephrology, Neurology, Oncology, Pharmacy, Pulmonology, Rheumatology, Journal, Source Type: news

Posttraumatic Stress Disorder and Trauma Exposure Linked to New-Onset Lupus in Women
No abstract available (Source: Lippincott's Bone and Joint Newsletter)
Source: Lippincott's Bone and Joint Newsletter - December 17, 2017 Category: Orthopaedics Tags: Snapshot Source Type: news

10 health questions that had you Googling this year
In 2017, you asked Dr. Google "What is keto diet," "What are opioids," and "What is lupus." Here are some of the top-trending health-related Google searches of the year. (Source: CNN.com - Health)
Source: CNN.com - Health - December 15, 2017 Category: Consumer Health News Source Type: news

Feistein Institute launches bioelectronic medicine trial for treating Lupus
Researchers at the Feinstein Institute launched a clinical trial looking to explore the efficacy of bioelectronic medicine specifically designed to manage pain associated with lupus. The study is exploring the use of a proprietary device, designed based upon previous research at the Feinstein Institute, which emits electrical pulses through a patient’s ear for five minutes a day over four days. “Lupus is a painful disease, notoriously hard to diagnose and difficult to treat – new treatment options are desperately needed. This trial will study an innovative approach to controlling symptoms of a d...
Source: Mass Device - December 14, 2017 Category: Medical Devices Authors: Fink Densford Tags: Blog The Feinstein Institute for Medical Research Source Type: news

Manifestations of Lupus in the Kidney and How to Manage Them Manifestations of Lupus in the Kidney and How to Manage Them
Find out what there is to know regarding the diagnosis of lupus nephritis and the available and emerging treatment strategies.Nephrology Dialysis Transplantation (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - December 14, 2017 Category: Consumer Health News Tags: Nephrology Journal Article Source Type: news

Costenbader Appointed Chair of Lupus Foundation of America ’s Medical-Scientific Advisory Council
Karen Costenbader, MD, MPH, director of the Lupus Program in the Division of Rheumatology, Immunology and Allergy, has been named as the chair of the Lupus Foundation of America ’s Medical-Scientific Advisory Council. (Source: BWH News)
Source: BWH News - December 13, 2017 Category: Hospital Management Source Type: news

How Does Pediatric Sj ö gren Syndrome Present?
Discussion Sjögren Syndrome (SS) is named for Swedish ophthalmologist Henrik Sjögren who published a case series in 1933 describing patients with dry eyes and arthritis. SS is a “chronic autoimmune inflammatory exocrinopathy” that is characterized by lymphocytic infiltration of the lacrimal and salivary glands and has various degrees of systematic involvement. Keratoconjunctivitis sicca and xerostomia are the main clinical symptoms. Sicca is a Latin word meaning dry. Dryness of the eyes and mouth without evidence of autoimmune disease is called Sicca syndrome or Sicca complex. SS can be primary or se...
Source: PediatricEducation.org - December 11, 2017 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Biomarker Predicts Lupus Nephritis Flares (CME/CE)
(MedPage Today) -- C4d more accurate than conventional complement C3 and C4 (Source: MedPage Today Rheumatology)
Source: MedPage Today Rheumatology - December 7, 2017 Category: Rheumatology Source Type: news

UAB awarded grant for Lupus research
A one-year, $250,000 grant will enable UAB researchers to make discoveries in Lupus development. The Lupus Research Alliance allocated the funding to the Birmingham university in an attempt to find explanations for how Lupus develops and the reason why some people are at greater risk for flare-ups and kidney disease. The work will be reviewed for additional funding pending progress at the en d of the first year.  “The results will form a solid foundation to develop interferon therapies and… (Source: bizjournals.com Health Care:Pharmaceuticals headlines)
Source: bizjournals.com Health Care:Pharmaceuticals headlines - December 4, 2017 Category: Pharmaceuticals Authors: Tyler Patchen Source Type: news

Medical News Today: How to cope with lupus
Living with the constant fatigue and pain of lupus can take its toll on both your mind and body, but steps can be taken to improve your quality of life. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - December 4, 2017 Category: Consumer Health News Tags: Lupus Source Type: news

Lupus and mental health: New study discovers the disease doubles the risk of dementia, regardless of age
(Natural News) Sometime between 2012 and 2014, singer and actress Selena Gomez was diagnosed with lupus, a chronic autoimmune disease where the body’s immune system attacks healthy tissue. According to a recent study, patients with lupus have double the risk of dementia. The study comes after earlier research which determined that patients with lupus can suffer from... (Source: NaturalNews.com)
Source: NaturalNews.com - December 4, 2017 Category: Consumer Health News Source Type: news

Medical News Today: The 10 best lupus blogs
Lupus blogs are written by experts and those with the disease to help support others with a similar diagnosis. We have compiled the 10 best lupus blogs. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 27, 2017 Category: Consumer Health News Tags: Lupus Source Type: news

MUSC leads research on potential research treatment
(Medical University of South Carolina) A five-year, $3.8 million grant from the Lupus Foundation of America funds phase 2 of a clinical trial evaluating a treatment using mesenchymal stem cells harvested from donated umbilical cords in patients with lupus resistant to treatment. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 16, 2017 Category: International Medicine & Public Health Source Type: news

Environmental factors may trigger lupus onset and progression
(University of Cincinnati Academic Health Center) While genetics play a role in the development of Lupus, a systemic autoimmune disease, so do environmental triggers, such as particulates in air pollution and ultraviolet light, says a University of Cincinnati researcher. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 16, 2017 Category: International Medicine & Public Health Source Type: news

Sex differences a rich field for UCLA multiple sclerosis researcher
As a child, Dr. Rhonda Voskuhl had terrible asthma, was often sick and had to get weekly allergy shots. She wondered why her body was so reactive to pollen, cats, wheat and eggs — her throat would swell, breathing became more difficult and her skin developed a rash. A frequent visitor to the doctor’s office, she had “a wonderful doctor who made me feel so much better.”It ’s no surprise, then, that Voskuhl grew up to become a doctor. Today, Voskuhl directs UCLA’s multiple sclerosis program and is the Jack H. Skirball professor of Multiple Sclerosis Research. She’s wrapping up one cl...
Source: UCLA Newsroom: Health Sciences - November 13, 2017 Category: Universities & Medical Training Source Type: news

Post-conflict opponent affiliation reduces victim re-aggression in a family group of captive arctic wolves (Canis lupus arctos) - Lazzaroni M, Marshall-Pescini S, Cafazzo S.
Post-conflict affiliative interactions have been widely investigated in primates but not extensively in other species. Using the Post Conflict-Matched Control (PC-MC) comparison method, this study investigated the patterns of post-conflict opponent affilia... (Source: SafetyLit)
Source: SafetyLit - November 13, 2017 Category: International Medicine & Public Health Tags: Non-Human Animals and Insects Source Type: news

Israeli scientists say lupus may double risk of dementia
Having lupus increases the risk of developing dementia for people who suffer from the chronic autoimmune disease, like Selena Gomez, by 51 percent, according to a new, large-scale study from Israel. (Source: the Mail online | Health)
Source: the Mail online | Health - November 10, 2017 Category: Consumer Health News Source Type: news

New ACR, EULAR Criteria Distinguish Lupus From Imitators New ACR, EULAR Criteria Distinguish Lupus From Imitators
Researchers from around the world contributed to the development of classification criteria for systemic lupus erythematosus (SLE) designed to distinguish the autoimmunity from common mimickers.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - November 9, 2017 Category: Consumer Health News Tags: Rheumatology News Source Type: news

Could Fish Oil, Vitamin D Help Ease Lupus?
THURSDAY, Nov. 9, 2017 -- People with lupus may fare better if they have enough vitamin D and omega-3 fats in their diet, preliminary research suggests. In separate studies, researchers linked the two nutrients -- or lack thereof -- to higher risks... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - November 9, 2017 Category: General Medicine Source Type: news

Medical News Today: Could lupus raise dementia risk?
Researchers from Israel have discovered that people with systemic lupus erythematosus may be at increased risk of developing dementia. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 9, 2017 Category: Consumer Health News Tags: Alzheimer's / Dementia Source Type: news

New Stanford University study reports sex differences in lupus-related premature death
(Mary Ann Liebert, Inc./Genetic Engineering News) Researchers have shown that women with systemic lupus erythematosus (SLE) in the US have an average 22-year shorter life expectancy compared to the general population, versus a 12-year average reduced life-span for men with SLE. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - November 9, 2017 Category: Infectious Diseases Source Type: news

Lupus linked with increased risk of dementia
(Wiley) A new International Journal of Geriatric Psychiatry study indicates that the risk of dementia may be elevated in individuals with systemic lupus erythematosus (SLE), an autoimmune disease affecting a range of systems including the peripheral and central nervous system. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 8, 2017 Category: International Medicine & Public Health Source Type: news

All babies in Europe should be screened for heart defects at birth
Only a few countries, including Poland, Ireland and Switzerland, currently recommend universal screening with pulse oximetry Related items fromOnMedica Blood test identifies high-risk lupus pregnancies Newborns screened for four additional genetic conditions Over 600,000 carry ‘sudden death’ gene fault The next generation of prenatal testing: let ’s proceed with caution Experts advise against screening for Duchenne Muscular Dystrophy (Source: OnMedica Latest News)
Source: OnMedica Latest News - November 8, 2017 Category: UK Health Source Type: news

No Gold Standard Biomarker for Lupus Flare Prediction
A recent systematic review of literature found no validated and widely accepted biomarker. (Source: ConsultantLive)
Source: ConsultantLive - November 7, 2017 Category: Internal Medicine Authors: Mariah Zebrowski Leach, JD, MS Tags: Lupus Source Type: news

Getting to the Bottom of Lupus Biology Getting to the Bottom of Lupus Biology
Rheumatologist Dr Mary K. Crow discusses her research into the molecular mechanisms behind lupus and promising new treatment approaches.Hospital for Special Surgery (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - November 7, 2017 Category: Consumer Health News Tags: Rheumatology Expert Interview Source Type: news

No Gold Standard Biomarker for Lupus Flare Prediction
A recent systematic review of literature found no validated and widely accepted biomarker. (Source: CancerNetwork)
Source: CancerNetwork - November 7, 2017 Category: Cancer & Oncology Authors: Mariah Zebrowski Leach, JD, MS Tags: Lupus Source Type: news

Stelara ® (ustekinumab) shows positive results in treatment of systemic lupus erythematosus in phase 2 trial
(Source: Johnson and Johnson)
Source: Johnson and Johnson - November 6, 2017 Category: Pharmaceuticals Source Type: news

Medical News Today: Lupus: Low vitamin D may raise risk of kidney failure
A new study examines the role of vitamin D deficiency in the organ inflammation and damage that occurs in systemic lupus erythematosus. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 6, 2017 Category: Consumer Health News Tags: Lupus Source Type: news

Could a saliva test be next for lupus?
(University of Houston) Chandra Mohan, a University of Houston professor of biomedical engineering, is proposing a simple lupus test that just uses saliva. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 6, 2017 Category: International Medicine & Public Health Source Type: news

Study shows lupus support line has positive impact
(Hospital for Special Surgery) A free telephone support and education program for people with lupus is a valuable resource to help them cope with the disease, according to a study at Hospital for Special Surgery (HSS) in New York City. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 6, 2017 Category: International Medicine & Public Health Source Type: news

Study: Lupus patients endorse PROMIS assessment tool as relevant, valuable and potentially useful in improving clinical care
(Hospital for Special Surgery) A study at Hospital for Special Surgery (HSS) evaluating the Patient Reported Outcomes Measurement Information System (PROMIS) finds that patients with lupus endorse the assessment tool as relevant, valuable and potentially useful in improving clinical care. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 6, 2017 Category: International Medicine & Public Health Source Type: news

What Causes White Nails?
Discussion The nail matrix covers the area of the nail plate, and extends proximally in a crescent moon shape with the edges of the crescent extending proximally and inferiorly toward the underlying bone. The nail matrix is a multilayered epithelium that physiologically produces keratinization and gives rise to the nail plate. The distal matrix forms the lower 2/3s of the nail plate and the proximal matrix forms the upper 1/3 of the nail plate. the thickness of the nail plate is proportion to the matrix’s thickness. The nail plate’s free edge contour follows the shape of the nail’s lunula. Melanocytes occ...
Source: PediatricEducation.org - November 6, 2017 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

J & J's Stelara shows promise against lupus in study
(Reuters) - Johnson& Johnson's blockbuster psoriasis drug Stelara led to a significant reduction in disease activity in patients with systemic lupus compared with a placebo in a midstage clinical trial, according to data released on Saturday. (Source: Reuters: Health)
Source: Reuters: Health - November 4, 2017 Category: Consumer Health News Tags: healthNews Source Type: news

Obesity linked with depressive symptoms & increased disease activity in women with lupus
(American College of Rheumatology) Obesity is independently associated with worse patient-reported outcomes in women with systemic lupus erythematosus, including disease activity, depressive symptoms, pain and fatigue, according to new research findings presented this week at the 2017 ACR/ARHP Annual Meeting in San Diego. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - November 4, 2017 Category: International Medicine & Public Health Source Type: news

Living with NASH: An Unexpected Diagnosis
As our waistlines thicken and our activity levels decrease, another chronic illness threatens to disturb our comfortable lifestyles. And, because it ’s relatively unknown, diagnosis comes as a shock to patients, who usually associate liver disease with heavy consumption of alcohol.Non-alcoholic steatohepatitis (NASH) is an advanced form of non-alcoholic fatty liver disease (NAFLD), where fat accumulates in the liver. It is most commonly associated with obesity, insulin resistance, metabolic syndrome and/or genetic polymorphisms, and is aggravated by inflammation and fibrosis.  First identified in the 1980s, its ...
Source: EyeForPharma - November 3, 2017 Category: Pharmaceuticals Authors: Mariel Metcalfe Source Type: news

Mortality rate for people with lupus remains higher than U.S. rate overall
FINDINGSWhile the mortality rate in the United States have declined over the past four decades, UCLA researchers found that the mortality rate for people with lupus has not declined as much as it has for the population overall.The researchers found that among people with lupus, mortality rates are still higher for black people than for other ethnicities; rates for women are higher than those of men; and those in the South were higher than for other regions of the U.S. Mortality rates for people with lupus were affected by where they lived.BACKGROUNDLupus is a chronic disease in which the immune system attacks the body &rsq...
Source: UCLA Newsroom: Health Sciences - November 1, 2017 Category: Universities & Medical Training Source Type: news