Poxvirus tricks cells into moving to spread infection
Vaccinia virus, a poxvirus closely related to smallpox and monkeypox, tricks cells it has infected into activating their own cell movement mechanism to rapidly spread the virus, according to a new study led by scientists at the MRC Laboratory for Molecular Cell Biology. (Source: Medical Research Council General News)
Source: Medical Research Council General News - November 12, 2018 Category: Research Source Type: news

Poxvirus hijacks cell movement to spread infection
(University College London) Vaccinia virus, a poxvirus closely related to smallpox and monkeypox, tricks cells it has infected into activating their own cell movement mechanism to rapidly spread the virus in cells and mice, according to a new UCL-led study published in Nature Microbiology. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - November 12, 2018 Category: Infectious Diseases Source Type: news

UK: health worker infected with smallpox-like disease
British officials say a health worker involved in treating a patient with monkeypox has been infected with the rare disease, suggesting possible lapses in the hospital's infection control procedures (Source: ABC News: Health)
Source: ABC News: Health - September 26, 2018 Category: Consumer Health News Tags: Health Source Type: news

Ask Well: How Long Do I Retain Immunity?
Antibody half-life varies tremendously, from about 11 years for tetanus to over 200 years for measles and mumps. (Source: NYT Health)
Source: NYT Health - September 21, 2018 Category: Consumer Health News Authors: RICHARD KLASCO, M.D. Tags: Mumps Measles Tetanus Smallpox Viruses Vaccination and Immunization Diphtheria Infections Source Type: news

Siga lands $629m BARDA contract to stockpile smallpox treatment
Siga Technologies (NSDQ:SIGA) said today that it signed a multi-year contract with the Biomedical Advanced Research & Development Authority to provide oral and intravenous versions of Siga’s Tpoxx smallpox treatment to the Strategic National Stockpile. The contract, which is valued at up to $629 million, also includes funding for advanced development of the the drug’s IV formulation and post-marketing activities for Tpoxx’s oral formulation. Get the full story at our sister site, Drug Delivery Business News. The post Siga lands $629m BARDA contract to stockpile smallpox treatment appeared first o...
Source: Mass Device - September 11, 2018 Category: Medical Devices Authors: Sarah Faulkner Tags: Funding Roundup Pharmaceuticals Wall Street Beat sigatechnologies Source Type: news

How smallpox claimed its final victim
How did British medical worker Janet Parker become the world's last victim of smallpox? (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - August 10, 2018 Category: Consumer Health News Source Type: news

D.C. Rap Up: Smallpox Rx; Essure Goes Away; Cirrhosis Deaths Spike
(MedPage Today) -- MedPage Today's weekly summary of policy news gets a hip-hop reboot from Cleavon Gilman, MD (Source: MedPage Today OB/GYN)
Source: MedPage Today OB/GYN - July 23, 2018 Category: OBGYN Source Type: news

Why there's finally a drug for smallpox even though the disease no longer exists
Enough doses for two million treatments have been delivered to the U.S. government's national emergency stockpile — and the Canadian government isn't ruling out the possibility of buying some. (Source: CBC | Health)
Source: CBC | Health - July 21, 2018 Category: Consumer Health News Tags: News/Health Source Type: news

Africa:Cracking the Cold Chain Challenge Is Key to Making Vaccines Ubiquitous
[The Conversation Africa] Over the years vaccines have prevented countless cases of disease and saved millions of lives. Infectious diseases like polio, measles, diphtheria, pertussis (whooping cough), rubella (German measles), smallpox, mumps, tetanus and rotavirus used to be common around the world. Today vaccines can prevent them. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - July 17, 2018 Category: African Health Source Type: news

FDA OKs first drug to treat smallpox, in case of terror attack
Smallpox was eradicated decades ago, but small samples of the virus ​ were saved for research purposes and some worry it could be used as a biological weapon (Source: Health News: CBSNews.com)
Source: Health News: CBSNews.com - July 16, 2018 Category: Consumer Health News Source Type: news

The first drug to treat smallpox wins FDA approval
Concerns that smallpox could be used as a biological weapon have now led to the first-ever approval of a drug to fight the disease. (Source: PharmaManufacturing.com)
Source: PharmaManufacturing.com - July 16, 2018 Category: Pharmaceuticals Source Type: news

FDA Approves First Drug to Treat Smallpox
MONDAY, July 16, 2018 -- TPOXX (tecovirimat) has been approved by the U.S. Food and Drug Administration to treat smallpox. Though the contagious and often-deadly viral disease was considered eradicated by the World Health Organization in 1980, there... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - July 16, 2018 Category: Pharmaceuticals Source Type: news

FDA OK's first drug to treat smallpox, in case of terror attack
Smallpox was eradicated decades ago, but small samples of the virus ​ were saved for research purposes and some worry it could be used as a biological weapon (Source: Health News: CBSNews.com)
Source: Health News: CBSNews.com - July 16, 2018 Category: Consumer Health News Source Type: news

FDA approves first drug to treat smallpox
The U.S. Food and Drug Administration has approved the first drug to treat smallpox. (Source: Health News - UPI.com)
Source: Health News - UPI.com - July 16, 2018 Category: Consumer Health News Source Type: news

First Drug, Tecovirimat (TPOXX), Approved to Treat Smallpox
MONDAY, July 16, 2018 -- TPOXX (tecovirimat) has been approved by the U.S. Food and Drug Administration to treat smallpox. Though the contagious and often-deadly viral disease was considered eradicated by the World Health Organization in 1980,... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - July 16, 2018 Category: General Medicine Source Type: news

Health Highlights: July 16, 2018
Here are some of the latest health and medical news developments, compiled by the editors of HealthDay: First Smallpox Drug Approved by FDA The first drug to treat smallpox has been approved by the U.S. Food and Drug Administration. A massive... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - July 16, 2018 Category: General Medicine Source Type: news

FDA Approves TPOXX To Be The 1st Drug For Smallpox
" You have smallpox, " are 3 words that you never want to hear. But having a treatment available like this one manufactured by SIGA Technologies is still quite important. (Source: Forbes.com Healthcare News)
Source: Forbes.com Healthcare News - July 15, 2018 Category: Pharmaceuticals Authors: Bruce Y. Lee, Contributor Source Type: news

FDA Approves TPOXX To Be The First Drug For Smallpox
" You have smallpox, " are 3 words that you never want to hear. But having a treatment available like this one manufactured by SIGA Technologies is still quite important. (Source: Forbes.com Healthcare News)
Source: Forbes.com Healthcare News - July 15, 2018 Category: Pharmaceuticals Authors: Bruce Y. Lee, Contributor Source Type: news

The FDA Approved an Anti-Bioterrorism Drug Meant to Treat Smallpox
The Food and Drug Administration (FDA) on Friday approved the first drug specifically designed to treat smallpox — despite the fact that the disease was officially eradicated in 1980. While the daily threat of smallpox, which is caused by the variola virus, is virtually non-existent, FDA Commissioner Scott Gottlieb said in a statement that the drug, called TPOXX, or tecovirimat, could be a safeguard against bioterrorism. “To address the risk of bioterrorism, Congress has taken steps to enable the development and approval of countermeasures to thwart pathogens that could be employed as weapons,” Gottlieb s...
Source: TIME: Health - July 14, 2018 Category: Consumer Health News Authors: Jamie Ducharme Tags: Uncategorized healthytime medicine onetime Source Type: news

FDA approves first drug to treat smallpox
The US Food and Drug Administration announced Friday its approval of the first drug to treat smallpox. (Source: CNN.com - Health)
Source: CNN.com - Health - July 14, 2018 Category: Consumer Health News Source Type: news

Drug to Treat Smallpox Approved by F.D.A., a Move Against Bioterrorism
Though the disease was eradicated decades ago, national security experts fear that stocks of the virus in labs could be released as a bioweapon. (Source: NYT Health)
Source: NYT Health - July 13, 2018 Category: Consumer Health News Authors: DONALD G. McNEIL Jr. Tags: Drugs (Pharmaceuticals) Biological and Chemical Warfare Viruses Terrorism Food and Drug Administration Smallpox Source Type: news

FDA OKs 1st drug to treat smallpox, in case of terror attack
US regulators approve 1st treatment for smallpox in case the long-gone disease is used in terror attack (Source: ABC News: Health)
Source: ABC News: Health - July 13, 2018 Category: Consumer Health News Tags: Health Source Type: news

FDA Approves TPOXX (tecovirimat) as the First Drug for the Treatment of Smallpox
July 13, 2018 -- The U.S. Food and Drug Administration today approved TPOXX (tecovirimat), the first drug with an indication for treatment of smallpox. Though the World Health Organization declared smallpox, a contagious and sometimes fatal... (Source: Drugs.com - New Drug Approvals)
Source: Drugs.com - New Drug Approvals - July 13, 2018 Category: Drugs & Pharmacology Source Type: news

Siga wins FDA nod for oral smallpox treatment
Siga Technologies (NSDQ:SIGA) today won FDA approval for its oral formulation of tecovirimat as a treatment of smallpox in the case of a potential outbreak. The drug is designed to mitigate the impact of a potential bioterrorism attack, according to the New York-based company. Siga also touted that the FDA granted its request for a priority review voucher, giving them the option for accelerated FDA review of a future product. Get the full story at our sister site, Drug Delivery Business News. The post Siga wins FDA nod for oral smallpox treatment appeared first on MassDevice. (Source: Mass Device)
Source: Mass Device - July 13, 2018 Category: Medical Devices Authors: Sarah Faulkner Tags: Food & Drug Administration (FDA) Pharmaceuticals Regulatory/Compliance Wall Street Beat sigatechnologies Source Type: news

FDA Approves Tecovirimat, First Drug for Smallpox Treatment FDA Approves Tecovirimat, First Drug for Smallpox Treatment
Tecovirimat (TPOXX) provides a treatment option should smallpox ever be used as a bioweapon and is the first product to be awarded a material threat medical countermeasure priority review voucher.FDA Approvals (Source: Medscape Internal Medicine Headlines)
Source: Medscape Internal Medicine Headlines - July 13, 2018 Category: Internal Medicine Tags: Infectious Diseases News Source Type: news

Smallpox Drug Wins FDA Nod
(MedPage Today) -- Tecovirimat approved without human efficacy data under special rules (Source: MedPage Today Public Health)
Source: MedPage Today Public Health - July 13, 2018 Category: American Health Source Type: news

FDA approves the first drug with an indication for treatment of smallpox
FDA today approved TPOXX (tecovirimat), the first drug with an indication for treatment of smallpox. (Source: Food and Drug Administration)
Source: Food and Drug Administration - July 13, 2018 Category: American Health Source Type: news

What is the Interval For Non-simultaneous Administration of Live Virus Vaccines?
Discussion Vaccines are a mainstay of infectious disease prevention and health promotion. Infants, children and adults benefit from vaccines the most when they are given on the recommended schedules. However there are times when this is not possible as children come to the physician a little early, or a little late, or had unavailable records and so received addition vaccine, etc. There are many questions that arise because of these timing issues such as the one above. Standard vaccine schedules can be reviewed here. Commonly administered vaccines includes: Live-attenuated vaccines Cholera Measles, mumps, rubella (MMR ...
Source: PediatricEducation.org - July 9, 2018 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Health Basics QUIZ: Which has killed more people, measles or the measles vaccine?
(Natural News) Surely you are paranoid about infectious diseases. You’ve seen horrific pictures of children with poliomyelitis, mumps, and even smallpox. You’ve heard that the science is “settled” as far as vaccines go, and that they are one hundred percent safe and effective. You’ve also never seen any media coverage of vaccine side effects or... (Source: NaturalNews.com)
Source: NaturalNews.com - July 5, 2018 Category: Consumer Health News Source Type: news

Siga Technologies touts pivotal data for oral smallpox therapy
Siga Technologies (NSDQ:SIGA) said today that data from a pivotal human safety study and animal efficacy studies of its oral smallpox therapy were published in the New England Journal of Medicine. Data from the studies support the efficacy and favorable safety profile of Tpoxx, an oral formulation of tecovirimat. Get the full story at our sister site, Drug Delivery Business News. The post Siga Technologies touts pivotal data for oral smallpox therapy appeared first on MassDevice. (Source: Mass Device)
Source: Mass Device - July 5, 2018 Category: Medical Devices Authors: Sarah Faulkner Tags: Clinical Trials Pharmaceuticals Wall Street Beat sigatechnologies Source Type: news

Immunosuppression, Past Vaccines, and Smallpox Reemergence Immunosuppression, Past Vaccines, and Smallpox Reemergence
Has the immunologic status of the population played a role in the re-emergence of the smallpox virus?Emerging Infectious Diseases (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - June 27, 2018 Category: Consumer Health News Tags: Infectious Diseases Journal Article Source Type: news

As D.I.Y. Gene Editing Gains Popularity, ‘ Someone Is Going to Get Hurt ’
After researchers created a virus from mail-order DNA, geneticists sound the alarm about the genetic tinkering carried out in garages and living rooms. (Source: NYT Health)
Source: NYT Health - May 14, 2018 Category: Consumer Health News Authors: EMILY BAUMGAERTNER Tags: Synthetic Biology Biological and Chemical Warfare Smallpox Federal Bureau of Investigation Genetic Engineering DNA (Deoxyribonucleic Acid) Laboratories and Scientific Equipment Source Type: news

Dr. Davida Coady, Medical Missionary, Is Dead at 80
She helped eradicate smallpox in India and reduce malnutrition in Africa, aided refugees in Latin America and later focused on drug and alcohol addictions. (Source: NYT Health)
Source: NYT Health - May 11, 2018 Category: Consumer Health News Authors: RICHARD SANDOMIR Tags: Coady, Davida Deaths (Obituaries) Medicine and Health Preventive Medicine Smallpox Drug Abuse and Traffic Republic of Biafra Malnutrition Source Type: news

FDA Lays the Smackdown on Illegal Stem Cell Clinics
FDA is cracking down on stem cell clinics that market unapproved products and don't meet good manufacturing practice requirements. On behalf of the agency, the Department of Justice filed two complaints in federal court this week seeking permanent injunctions against a Florida-based clinic and a California-based clinic.  “Cell-based regenerative medicine holds significant medical opportunity, but we’ve also seen some bad actors leverage the scientific promise of this field to peddle unapproved treatments that put patients’ health at risk. In some instances, patients have suffered serious and per...
Source: MDDI - May 10, 2018 Category: Medical Devices Authors: Amanda Pedersen Tags: Regulatory and Compliance Source Type: news

Products Approved for Other Bioterrorism Emergencies
U.S. Food and Drug Administration. 09/08/2017 This Web page lists products approved for seven bioterrorism emergencies: Botulism due to Clostridium botulinum toxin; Ebola Virus Disease (EVD); Glanders and Melioidosis due to Burkholderia mallei and B. pseudomallei, respectively; Plague due to Yersinia pestis; Smallpox due to Variola major and Variola minor; Tularemia due to Francisella tularensis; and Zika Virus Disease. (Text) (Source: Disaster Lit: Resource Guide for Disaster Medicine and Public Health)
Source: Disaster Lit: Resource Guide for Disaster Medicine and Public Health - May 9, 2018 Category: International Medicine & Public Health Authors: The U.S. National Library of Medicine Source Type: news

How to Wipe Out Malaria for Good
Malaria has plagued humanity for thousands of years. Caused by a tiny parasite transported from person to person by a certain kind of mosquito, the disease poses a risk to nearly half the world’s population. The WHO attempted to eradicate malaria in the 1960s and while it succeeded in ridding many countries of the disease, it fell short of the goal due to growing drug resistance and by failing to focus enough attention on Africa. Every year on World Malaria Day, April 25, the malaria community celebrates progress made to date and focuses on the challenges ahead. This year is especially exciting as just this past Fri...
Source: TIME: Health - April 25, 2018 Category: Consumer Health News Authors: Erin M. Stuckey Tags: Uncategorized Bill and Melinda Gates Foundation Malaria World Malaria Day Source Type: news

WHO at 70 - working for better health for everyone, everywhere
On 7 April, World Health Day, the World Health Organization marks its 70th anniversary. Over the past 7 decades, WHO has spearheaded efforts to rid the world of killer diseases like smallpox and to fight against deadly habits like tobacco use. This year, World Health Day is dedicated to one of WHO ’s founding principles: “The enjoyment of the highest attainable standard of health is one of the fundamental rights of every human being without distinction of race, religion, political belief, economic or social condition.” (Source: WHO news)
Source: WHO news - April 5, 2018 Category: International Medicine & Public Health Tags: universal health coverage [subject], universal health care, universal access Source Type: news

People can ’t be educated into vaccinations, but behavioral nudges help, study finds
Vaccines were one of the great inventions of modern history. They helped stop America’s polio epidemic in the 1950s, when it was paralyzing thousands and killing at least 3,000 a year. They have prevented the deaths of millions worldwide from diseases such as diphtheria, smallpox, measles and tetanus. And yet many people are reluctant to get their shots […]Related:In case you missed the ‘condom-snorting challenge’ — and didn’t know it’s a bad ideaAs controversial ‘abortion reversal’ laws increase, researcher says new data shows protocol can workA woman s...
Source: Washington Post: To Your Health - April 4, 2018 Category: Consumer Health News Source Type: news

ECMC ’s Beginnings: Buffalo City Hospital – 1918-1939
The roots of the hospital that became ECMC can be traced back to the early 20th century and the Municipal Hospital on East Ferry Street, which was designed for the care of smallpox patients. Although compulsory smallpox vaccination had been proven effective for more than a century, the disease had not been completely wiped out and there were still isolated cases in Buffalo. Then in 1909, a scarlet fever epidemic struck 3,000 Buffalo residents and a vacant schoolhouse was requisitioned as a contagious … (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - March 6, 2018 Category: Biotechnology Authors: Supplied by ECMC Source Type: news

Oregon-developed biological warfare drug treatment nears FDA finish line
Siga Technologies Inc.'s research and development operation in Corvallis for 15 years has been developing an antiviral drug that targets smallpox (Source: bizjournals.com Health Care:Physician Practices headlines)
Source: bizjournals.com Health Care:Physician Practices headlines - March 1, 2018 Category: American Health Authors: Elizabeth Hayes Source Type: news

Smallpox (Vaccinia) Vaccine, Live
(Source: What's New at CBER)
Source: What's New at CBER - March 1, 2018 Category: Biomedical Science Source Type: news

Planning for smallpox outbreak must consider immunosuppression
(University of New South Wales) New research from UNSW Sydney reveals that the number of people living with weakened immune systems must be examined when planning for the real risk of smallpox re-emerging in the world. The research poses a warning after Canadian scientists last year created a smallpox-like virus in a lab using just mail order DNA. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - March 1, 2018 Category: Infectious Diseases Source Type: news

CDC Wants $400 Million to Build a New Lab for the World ’s Deadliest Germs
(NEW YORK) — Thirteen years after building a state-of-the-art lab for the world’s most dangerous germs, the nation’s top public health agency is asking for more than $400 million to build a new one. Officials at the Centers for Disease Control and Prevention say the current lab building in Atlanta is quickly wearing down, and cannot be upgraded without shutting down the facility for years. The lab investigates deadly and exotic germs like Ebola, smallpox and dangerous new forms of flu.The agency disclosed its plans for a new lab on Friday. The CDC lab is one of only eight U.S. labs with the security and s...
Source: TIME: Science - February 24, 2018 Category: Science Authors: Mike Stobbe / AP Tags: Uncategorized APH healthytime medicine onetime Source Type: news

Controversy among scientists as “horsepox recipe” becomes public knowledge, raising fears terrorists will "hack" the virus to kill millions
(Natural News) A controversial paper, which was published in an issue of the journal PLOS ONE and which documents how to make a virus, has sparked public outcry in the scientific community. This bug, which is non-threatening to humans, is genetically similar to smallpox — a disease which killed at least 300 million people in the... (Source: NaturalNews.com)
Source: NaturalNews.com - February 24, 2018 Category: Consumer Health News Source Type: news

CDC seeks new labs for bioterror pathogens to replace aging facility
ATLANTA — Inside a complex of special government labs, scientists in full-body protective suits work with some of the world’s deadliest pathogens: Ebola, smallpox and certain strains of bird flu. Many of the organisms have no treatment or vaccine, so the labs housed in this facility on the sprawling campus of the Centers for Disease […]Related:Flu cases fall for the first time this awful influenza seasonCDC warns about salmonella infections traced to kratomHere’s what you should know about the flu season this year (Source: Washington Post: To Your Health)
Source: Washington Post: To Your Health - February 23, 2018 Category: Consumer Health News Source Type: news

SIGA Technologies Announces FDA Accepts NDA and Grants Priority Review for Oral TPOXX to Treat Smallpox
If approved, TPOXX would be the first treatment for smallpox NEW YORK, Feb. 07, 2018 -- (Healthcare Sales & Marketing Network) -- SIGA Technologies, Inc. (SIGA) (OTCMKTS:SIGA), a health security company specializing in the development and commercializat... Biopharmaceuticals, FDA SIGA Technologies, TPOXX, tecovirimat, smallpox (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - February 8, 2018 Category: Pharmaceuticals Source Type: news

Smallpox vaccine study yields favorable results
(US Army Medical Research Institute of Infectious Diseases) Officials from Bavarian Nordic yesterday announced the results of a successful Phase 3 clinical trial led by USAMRIID that demonstrated the safety and efficacy of the company's investigational, non-replicating smallpox vaccine, IMVAMUNE ® . The product is being developed as an alternative to the current U.S. licensed replicating smallpox vaccine, ACAM2000 ® , which cannot be used by certain populations, including people with atopic dermatitis and HIV. It is already approved in Canada and the European Union. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - February 7, 2018 Category: Infectious Diseases Source Type: news

SIGA Technologies Announces FDA Accepts NDA and Grants Priority Review for Oral TPOXX to Treat Smallpox
NEW YORK, Feb. 07, 2018 (GLOBE NEWSWIRE) -- SIGA Technologies, Inc. (SIGA) (OTCMKTS:SIGA), a health security company specializing in the development and commercialization of solutions for serious unmet medical needs and biothreats, today announced... (Source: Drugs.com - New Drug Applications)
Source: Drugs.com - New Drug Applications - February 7, 2018 Category: Drugs & Pharmacology Source Type: news

Operational Framework for the Deployment of the World Health Organization Smallpox Vaccine Emergency Stockpile in Response to a Smallpox Event
World Health Organization. 12/2017 This 76-page operational framework describes the World Health Organization (WHO) Smallpox Vaccine Emergency Stockpile (SVES), and the considerations and processes needed for countries to request vaccine in the event of a smallpox outbreak. It also describes the processes by which donors can deploy vaccine to the WHO SVES, and WHO can deploy vaccine to requesting countries. (PDF) (Source: Disaster Lit: Resource Guide for Disaster Medicine and Public Health)
Source: Disaster Lit: Resource Guide for Disaster Medicine and Public Health - January 24, 2018 Category: International Medicine & Public Health Authors: The U.S. National Library of Medicine Source Type: news

'The world is now more vulnerable to smallpox'
Experts have attacked the publication of the new study, led by scientists at the University of Alberta, Canada. It shows precisely how to construct horsepox - a close relative of the feared bug. (Source: the Mail online | Health)
Source: the Mail online | Health - January 23, 2018 Category: Consumer Health News Source Type: news