China HIV Patients Risk Running Out of AIDS Drugs in Days -UNAIDS China HIV Patients Risk Running Out of AIDS Drugs in Days -UNAIDS
HIV patients in China risk running out of life-saving AIDS drugs because quarantines and lockdowns aimed at containing the coronavirus disease outbreak mean they cannot replenish vital medicine stocks, United Nations AIDS agency said on Wednesday.Reuters Health Information (Source: Medscape Hiv-Aids Headlines)
Source: Medscape Hiv-Aids Headlines - February 22, 2020 Category: Infectious Diseases Tags: HIV/AIDS News Source Type: news

South Africa: South Africa's Next Generation Powerhouse Aids Activist
[Daily Maverick] The Treatment Action Campaign's Vuyokazi 'Vovo' Gonyela sat down with Maverick Citizen to discuss how she got into the world of health activism, her outlook on civil society and what it takes to be an activist. (Source: AllAfrica News: HIV-Aids and STDs)
Source: AllAfrica News: HIV-Aids and STDs - February 21, 2020 Category: Infectious Diseases Source Type: news

Zimbabwe: Dutch Experts Descend On Cyclone Idai-Ravaged Areas
[Zimbabwe Independent] Ten companies from the Netherlands have committed to offering financial and technical assistance to rehabilitating Chimanimani district following the damage caused by tropical cyclone Idai last year. (Source: AllAfrica News: HIV-Aids and STDs)
Source: AllAfrica News: HIV-Aids and STDs - February 21, 2020 Category: Infectious Diseases Source Type: news

Kenya: Women Living With HIV Twice as Many As Men - Survey
[East African] About 1.3 million adults in Kenya are living with HIV/Aids, an estimated 4.9 percent of those aged between 15 to 64 years old, according to a new survey. (Source: AllAfrica News: HIV-Aids and STDs)
Source: AllAfrica News: HIV-Aids and STDs - February 21, 2020 Category: Infectious Diseases Source Type: news

Another HIV Hazard: Higher Risk for COPD
Compared to those without the AIDS-causing virus, people with HIV had a 34% higher rate of COPD and were diagnosed with the lung disease about 12 years earlier -- average age 50 versus 62, the investigators found. (Source: WebMD Health)
Source: WebMD Health - February 20, 2020 Category: Consumer Health News Source Type: news

Another HIV Hazard: Higher Risk for COPD
(Source: Pulmonary Medicine News - Doctors Lounge)
Source: Pulmonary Medicine News - Doctors Lounge - February 20, 2020 Category: Respiratory Medicine Tags: Family Medicine, Pulmonology, AIDS, Preventive Medicine, News, Source Type: news

Doctors look to HIV and Ebola drugs for coronavirus cure
Early results of trials on Covid-19 patients expected in MarchDoctors are likely to know within two to three weeks whether drugs being used to treat patients infected with the new coronavirus are working, according to the World Health Organization.The timetable for early results from two trials taking place in China is short but feasible because of the large concentration of sick people at the centre of the outbreak in Hubei province. That allows a significant number of people of similar ages, fitness and stage of illness to be compared.Continue reading... (Source: Guardian Unlimited Science)
Source: Guardian Unlimited Science - February 20, 2020 Category: Science Authors: Sarah Boseley Health editor Tags: Medical research Drugs Coronavirus outbreak Infectious diseases Microbiology Science World news Ebola Aids and HIV Society China Asia Pacific Source Type: news

Many Transgender Youth Intentionally Avoid Disclosure
About three - quarters report voluntarily telling a health care provider outside gender clinic about their identity (Source: The Doctors Lounge - Psychiatry)
Source: The Doctors Lounge - Psychiatry - February 20, 2020 Category: Psychiatry Tags: Cardiology, Dermatology, Endocrinology, Family Medicine, Geriatrics, Gastroenterology, Gynecology, Infections, AIDS, Internal Medicine, Allergy, Critical Care, Emergency Medicine, Nephrology, Neurology, Nursing, Oncology, Ophthalmology, Orthopedics, ENT, Source Type: news

COPD Incidence Higher in People With HIV
People with HIV have 34 percent higher rate of COPD than those without; smoking may be to blame (Source: Pulmonary Medicine News - Doctors Lounge)
Source: Pulmonary Medicine News - Doctors Lounge - February 20, 2020 Category: Respiratory Medicine Tags: Family Medicine, Internal Medicine, Nursing, Pulmonology, AIDS, Journal, Source Type: news

Russian Blogger's HIV Documentary Reaches Millions, Draws Kremlin Praise Russian Blogger's HIV Documentary Reaches Millions, Draws Kremlin Praise
A hard-hitting YouTube documentary about Russia's HIV epidemic by a popular blogger has attracted more than 13 million views in a week and even drawn praise from the Kremlin.Reuters Health Information (Source: Medscape Hiv-Aids Headlines)
Source: Medscape Hiv-Aids Headlines - February 20, 2020 Category: Infectious Diseases Tags: HIV/AIDS News Source Type: news

Carestream Dental and Burkhart Dental Supply Partner to Deliver Digital Technology to More Doctors
ATLANTA—Doctors will soon have greater access to Carestream Dental ’s innovative technology thanks to a new partnership with Burkhart Dental Supply. As an authorized dealer, Burkhart will be able to market, sell, install and service nearly all of Carestream Dental’s equipment, accessories and imaging software.No matter where a doctor is on their digital journey, this new partnership makes it easy for the Burkhart team to guide and support them along the way with access to Carestream Dental technology. For example, the CS 8100 3D extraoral imaging system can capture high-resolution 3D images for a more con...
Source: Dental Technology Blog - February 20, 2020 Category: Dentistry Source Type: news

Africa: We Can Make Our World Better – Mark Suzman of Gates Foundation
[allAfrica] Cape Town -AllAfrica's Juanita Williams talked with Mark Suzman, the CEO of the Bill and Melinda Gates Foundation, the world's largest philanthropy. He assumed the position this month. In this second part of the interview, he discussed how his early career as a journalist in his native South Africa influences his perspectives; about the possibilities of eliminating malaria and reducing HIV, TB and other diseases; addressing hunger and undernutrition amid the climate crisis; and the biggest challenges he faces. Part 2 (Source: AllAfrica News: HIV-Aids and STDs)
Source: AllAfrica News: HIV-Aids and STDs - February 20, 2020 Category: Infectious Diseases Source Type: news

Can Hearing Aids Help Prevent Dementia?
Research suggests that paying more attention to the “invisible disability” of hearing loss might improve our brains. (Source: NYT Health)
Source: NYT Health - February 20, 2020 Category: Consumer Health News Authors: Kim Tingley Tags: Ears and Hearing Alzheimer ' s Disease Dementia Hearing Aids Brain Source Type: news

Sexual Orientation, Gender Identity Tied to Skin Cancer Risk Sexual Orientation, Gender Identity Tied to Skin Cancer Risk
Skin cancer risk may vary according to sexual orientation and gender identity, two new studies suggest.Reuters Health Information (Source: Medscape Hiv-Aids Headlines)
Source: Medscape Hiv-Aids Headlines - February 20, 2020 Category: Infectious Diseases Tags: Hematology-Oncology News Source Type: news

Japan Plans HIV Drug Trials to Fight Coronavirus as Diamond Princess Cases Rise Japan Plans HIV Drug Trials to Fight Coronavirus as Diamond Princess Cases Rise
Japan plans to start trials of HIV medications to treat coronavirus patients as an increase in the number of cases poses a growing threat to the economy and public health, the government's top spokesman said on Tuesday.Reuters Health Information (Source: Medscape Hiv-Aids Headlines)
Source: Medscape Hiv-Aids Headlines - February 20, 2020 Category: Infectious Diseases Tags: Public Health & Prevention News Source Type: news

U.S. President ’s Global Gag Rule is Having Negative Impact on the Health of Malawians: Report
A Malawian nurse at a training session. A report looking into the discontinuation of U.S. global health assistance to foreign non-governmental facilities providing abortion or abortion-related services, says that the ban is affecting the population in Malawi. Credit:Claire Ngozo/IPS By Samira SadequeUNITED NATIONS, Feb 19 2020 (IPS) A report released last week has detailed the complex ways in which President Donald Trump’s ‘Global Gag Rule’ (GGR), that blocks U.S. global health assistance to foreign non-governmental facilities providing abortion or abortion-related services, is affecting the population in...
Source: IPS Inter Press Service - Health - February 19, 2020 Category: International Medicine & Public Health Authors: Samira Sadeque Tags: Africa Development & Aid Featured Gender Headlines Health IPS UN: Inside the Glasshouse North America TerraViva United Nations Women's Health CHANGE Marie Stopes International (MSI) the Center for Health and Gender Equity Source Type: news

Speed science: The risks of swiftly spreading coronavirus research
One scientific post suggests links between the new coronavirus and AIDS, a second says it may have passed to people via snakes, while a third claims it is a pathogen from outer space. (Source: Reuters: Health)
Source: Reuters: Health - February 19, 2020 Category: Consumer Health News Tags: healthNews Source Type: news

China HIV patients risk running out of AIDS drugs in days: UNAIDS
HIV patients in China risk running out of life-saving AIDS drugs because quarantines and lockdowns aimed at containing the coronavirus disease outbreak mean they cannot replenish vital medicine stocks, United Nations AIDS agency said on Wednesday. (Source: Reuters: Health)
Source: Reuters: Health - February 19, 2020 Category: Consumer Health News Tags: healthNews Source Type: news

HIV Testing Outcomes Among Blacks or African Americans HIV Testing Outcomes Among Blacks or African Americans
This analysis found that HIV testing services supported by CDC funding are an important resource for identifying persons with new and previously diagnosed HIV infection who are not in care.Morbidity & Mortality Weekly Report (Source: Medscape Hiv-Aids Headlines)
Source: Medscape Hiv-Aids Headlines - February 19, 2020 Category: Infectious Diseases Tags: HIV/AIDS Journal Article Source Type: news

Performing the Initial Assessment of HIV-Positive Patients Performing the Initial Assessment of HIV-Positive Patients
A new study examines the question of whether guidelines for the initial assessment of HIV-positive individuals are being appropriately adhered to.HIV Medicine (Source: Medscape Hiv-Aids Headlines)
Source: Medscape Hiv-Aids Headlines - February 19, 2020 Category: Infectious Diseases Tags: HIV/AIDS Journal Article Source Type: news

NIH Slated for 7 percent Budget Cut
The President has proposed a $38.7 billion budget for the National Institutes of Health in fiscal year (FY) 2021. This translates to a $3 billion or 7 percent cut in the agency’s funding compared to FY 2020. The NIH budget request includes a $50 million initiative to use artificial intelligence (AI) to develop a better understanding of the causes of chronic diseases and to identify early treatments. This plan is in line with the Administration’s “Industries of the Future” effort, which supports using and developing AI across sectors. The budget would provide $50 million for the Childhood Cancer ...
Source: Public Policy Reports - February 18, 2020 Category: Biology Authors: AIBS Source Type: news

PEPFAR: FDA Approves 200th HIV/AIDS Therapy
(Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - February 18, 2020 Category: Drugs & Pharmacology Authors: FDA Source Type: news

Namibia: HIV/Aids Activist Takes On Aquaponics
[Namibian] THE Immanuel Sheefeni AIDS Foundation is developing a fish farm at Outapi to produce shrimps, tilapia and a mix of vegetables for local and regional food markets. (Source: AllAfrica News: HIV-Aids and STDs)
Source: AllAfrica News: HIV-Aids and STDs - February 18, 2020 Category: Infectious Diseases Source Type: news

Cameroon: Fight Against Drugs, HIV, Cyber Crimes - CERAC Educates Campo Youths
[Cameroon Tribune] The occasion was also an opportunity for the charitable association of the First Lady to hand over gifts to some schools and youth associations in the locality of the South Region. (Source: AllAfrica News: HIV-Aids and STDs)
Source: AllAfrica News: HIV-Aids and STDs - February 18, 2020 Category: Infectious Diseases Source Type: news

Gut Microbiota Dysbiosis in HBV-induced Chronic Liver Disease Gut Microbiota Dysbiosis in HBV-induced Chronic Liver Disease
Using a gene sequencing approach, this study examined the gut microbiota profile of patients with hepatitis B virus-induced chronic liver disease compared with healthy controls.Journal of Viral Hepatitis (Source: Medscape Hiv-Aids Headlines)
Source: Medscape Hiv-Aids Headlines - February 18, 2020 Category: Infectious Diseases Tags: Gastroenterology Journal Article Source Type: news

Botswana: Plan Brings Hope
[Botswana Daily News] Mahalapye -The Faith and Community Initiative Project aimed at combating HIV/AIDS in Botswana brings a message of hope to the country, says Vice President Slumber Tsogwane. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - February 18, 2020 Category: African Health Source Type: news

Amyloid PET results prompt adults to rethink their future
When PET scans reveal elevated amyloid levels in cognitively normal older adults,...Read more on AuntMinnie.comRelated Reading: FDG-PET shows where exercise could stall Alzheimer's PET, MRI link amyloid plaque with swift decline Who should get brain scans for Alzheimer's disease? PET, MRI show physical activity aids brain health Would high amyloid level spur physician-assisted death? (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - February 18, 2020 Category: Radiology Source Type: news

A New Page in Life
By Anna-Maija Mattila-Litvak, Supervisory Development Outreach and Communications Officer Anita Nakazibwe holds her daughter Emmanuela. While mom is HIV-positive, the toddler remains HIV-negative —a fact that brings Anita great joy. Photo by Anna-Maija Mattila-Litvak, USAID/Uganda.February 17, 2020“My first treatment was a smile!” says Anita Nakazibwe about the welcome she got when she first came to Moroto Regional Referral Hospital in eastern Uganda. Anita holds her year-and-a-half-old baby girl Emmanuela in her arms and is beaming. She gave birth at the hospital to a healthy baby, although she herse...
Source: IntraHealth International - February 17, 2020 Category: International Medicine & Public Health Authors: kseaton Tags: HIV & AIDS Maternal, Newborn, Child Health Nurses Source Type: news

In Uganda, Nurses Help Families Like Anita's Thrive
By Anna-Maija Mattila-Litvak, Supervisory development outreach and communications officer, USAID Anita Nakazibwe holds her daughter Emmanuela. While mom is HIV-positive, the toddler remains HIV-negative —a fact that brings Anita great joy. Photo by Anna-Maija Mattila-Litvak, USAID/Uganda.February 17, 2020“My first treatment was a smile!” says Anita Nakazibwe about the welcome she got when she first came to Moroto Regional Referral Hospital in eastern Uganda. Anita holds her year-and-a-half-old baby girl Emmanuela in her arms and is beaming. She gave birth at the hospital to a healthy baby, although sh...
Source: IntraHealth International - February 17, 2020 Category: International Medicine & Public Health Authors: kseaton Tags: HIV & AIDS Maternal, Newborn, Child Health Nurses Source Type: news

Beyond band-aids for bullet holes: firearm violence as a public health priority - Kaufman EJ, Richmond TS.
OBJECTIVES: To review the public health approach to preventing and treating firearm violence. DATA SOURCES: Peer-reviewed, published scholarship and federal data systems. STUDY SELECTION: English-language, indexed research articles on the epidemiology, ris... (Source: SafetyLit)
Source: SafetyLit - February 17, 2020 Category: International Medicine & Public Health Tags: Commentary Source Type: news

Identification and differentiation of commercial and military explosives via high performance liquid chromatography - high resolution mass spectrometry (HPLC-HRMS), X-ray diffractometry (XRD) and X-ray fluorescence spectroscopy (XRF): towards a forensic substance database on explosives - Schachel TD, Stork A, Schulte-Ladbeck R, Vielhaber T, Karst U.
The identification of confiscated commercial and military explosives is a crucial step not only in the uncovering of distribution pathways, but it also aids investigating officers in criminal casework. Even though commercial and military explosives mainly ... (Source: SafetyLit)
Source: SafetyLit - February 17, 2020 Category: International Medicine & Public Health Tags: Burns, Electricity, Explosions, Fire, Scalds Source Type: news

10 African Americans Who Have Shaped  Public Health
By Casey Bishopp, Communications officer, IntraHealth International ; Sabra Farquharson, Business development officer, IntraHealth InternationalFebruary 18, 2020We’re celebrating the legacies of ten African Americans in public health this month—shining a light on the invaluable contributions made by these scholars and health workers. According to themost recent report form the Health Resources and Services Administration, African Americans make up 11.6% of the US health workforce, and throughout American history have made invaluable contributions to greater public health in fields s...
Source: IntraHealth International - February 17, 2020 Category: International Medicine & Public Health Authors: cbishopp Source Type: news

Africa: The Search for an Effective HIV Vaccine Continues
[The Conversation Africa] An HIV vaccine trial that started in 2016 in South Africa was halted in February 2020. The study sponsors made the call after interim results showed that the vaccine, known as HVTN 702, did not prevent HIV. This result was disappointing, but the search for an effective HIV vaccine continues. Anatoli Kamali speaks to The Conversation Africa's Ina Skosana about other developments in the field. (Source: AllAfrica News: HIV-Aids and STDs)
Source: AllAfrica News: HIV-Aids and STDs - February 17, 2020 Category: Infectious Diseases Source Type: news

Telemarketer Access to Medicare Information to Be Investigated
Audit comes in response to surge of telemarketing scams targeting Medicare recipients (Source: Pulmonary Medicine News - Doctors Lounge)
Source: Pulmonary Medicine News - Doctors Lounge - February 15, 2020 Category: Respiratory Medicine Tags: Cardiology, Dermatology, Endocrinology, Family Medicine, Geriatrics, Gastroenterology, Gynecology, Infections, AIDS, Internal Medicine, Allergy, Nephrology, Neurology, Oncology, Ophthalmology, Orthopedics, ENT, Pharmacy, Psychiatry, Pulmonology, Rheumatol Source Type: news

U.S. Life Expectancy to Reach 85 by 2060
Census Bureau predicts life expectancy will increase by about six years between 2017 and 2060 (Source: Pulmonary Medicine News - Doctors Lounge)
Source: Pulmonary Medicine News - Doctors Lounge - February 15, 2020 Category: Respiratory Medicine Tags: Cardiology, Dermatology, Endocrinology, Family Medicine, Geriatrics, Gastroenterology, Gynecology, Infections, AIDS, Internal Medicine, Allergy, Critical Care, Emergency Medicine, Nephrology, Neurology, Nursing, Oncology, Ophthalmology, Orthopedics, ENT, Source Type: news

Injected Heroin Use Still High in U.S., May Explain HCV Infection Rate Injected Heroin Use Still High in U.S., May Explain HCV Infection Rate
Heroin use by injection has leveled off in recent years but had been rising steadily for more than a decade, a study finds.Reuters Health Information (Source: Medscape Hiv-Aids Headlines)
Source: Medscape Hiv-Aids Headlines - February 14, 2020 Category: Infectious Diseases Tags: Psychiatry News Source Type: news

The Cost-Effectiveness of Localized HIV Prevention and Care The Cost-Effectiveness of Localized HIV Prevention and Care
A new analysis examines the cost-effectiveness of HIV treatment and prevention interventions across diverse epidemiological settings.AIDS (Source: Medscape Hiv-Aids Headlines)
Source: Medscape Hiv-Aids Headlines - February 14, 2020 Category: Infectious Diseases Tags: HIV/AIDS Journal Article Source Type: news

Nigeria: Govt May Deploy HIV Drugs to Treat Coronavirus - NACA
[This Day] The federal government has said it may as well deploy HIV drug, Kaletra, to treat the Coronavirus in the event that it gets to Nigeria. (Source: AllAfrica News: HIV-Aids and STDs)
Source: AllAfrica News: HIV-Aids and STDs - February 14, 2020 Category: Infectious Diseases Source Type: news

Most Gay, Bisexual Male Adolescents Don't Get Tested for HIV Most Gay, Bisexual Male Adolescents Don't Get Tested for HIV
Fewer than one in four adolescent men who have sex with men (AMSM) have had an HIV test, new U.S. research shows.Reuters Health Information (Source: Medscape Hiv-Aids Headlines)
Source: Medscape Hiv-Aids Headlines - February 13, 2020 Category: Infectious Diseases Tags: HIV/AIDS News Source Type: news

10 Global Health Issues to Watch in the 2020s
By Margarite Nathe, Principal Editor/Writer, IntraHealth International Midwives and nurses —like Sellyvine (left) at the women's hospital in Nakuru, Kenya —make up 50% of the health workforce worldwide. They're in the spotlight during 2020 and will play a crucial role in whether their countries can achieve their most ambitious health targets by 2030. Photo by Georgina Goodwin for IntraHealth International.February 14, 2020Every year, we look at the top global health issues coming our way in the next 12 months. But global health is a long game and it’s a brand-new decade, so this year, we’re look...
Source: IntraHealth International - February 13, 2020 Category: International Medicine & Public Health Authors: mnathe Tags: Family Planning & Reproductive Health HIV AIDS Infectious Diseases Maternal, Newborn, Child Health Mental Health Noncommunicable Diseases Digital Health Policy Advocacy Gender Equality Nursing Midwifery Youth Midwives N Source Type: news

Polly Dunford to Lead IntraHealth International as New President and CEO
February 14, 2020 Chapel Hill, NCToday, IntraHealth International’s board of directors announced Polly Dunford will be IntraHealth’s next president and CEO. She will assume the role on March 16.Dunford is joining IntraHealth after nearly 20 years of service with the US Agency for International Development (USAID) in Cambodia, Haiti, Jordan, Mozambique, Nigeria and Washington, D.C., most recently as the global director for HIV/AIDS. In this role, she led the agency’s efforts to help countries achieve and sustain epidemic control of HIV/AIDS under the President’s Emergency Plan for AIDS Relief ...
Source: IntraHealth International - February 13, 2020 Category: International Medicine & Public Health Authors: intrahealth Tags: Leadership and Governance Source Type: news

New Report Evaluates PEPFAR Investments in Strengthening the Health Workforce in Rwanda
A new report from the National Academies of Sciences, Engineering, and Medicine examines how Human Resources for Health (HRH) in Rwanda— a program funded in part by the President’s Emergency Plan for AIDS Relief (PEPFAR) from 2012 to 2017— affected morbidity and mortality outcomes for people living with HIV. HRH Rwanda aimed to increase the number and quality of physicians, nurses, and midwives specializing in HIV care. The report offers recommendations and lessons that other countries can apply to improve HIV workforce development and strengthen their health systems at large. Read More (Source: News from...
Source: News from the National Academies - February 13, 2020 Category: Science Source Type: news

Nigeria: How Nutrition Education Can Make a Difference to People With HIV
[The Conversation Africa] HIV and AIDS are still global health problems and sub-Saharan Africa remains the most affected region. Globally, around 770,000 people died from AIDS-related conditions in 2018, 160,000 of them in West and Central Africa. (Source: AllAfrica News: HIV-Aids and STDs)
Source: AllAfrica News: HIV-Aids and STDs - February 13, 2020 Category: Infectious Diseases Source Type: news

FDG-PET/CT points to cervical cancer patient outcomes
Several indicators on pretreatment FDG-PET/CT scans can help predict overall...Read more on AuntMinnie.comRelated Reading: Biomarkers on PET, MRI show breast cancer risk FDG-PET/CT within a year of heart valve surgery looks safe FDG-PET/CT helps predict tuberculosis relapse 2 new PET tracers may best FDG in cancer imaging FDG-PET/CT aids in melanoma treatment assessment (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - February 13, 2020 Category: Radiology Source Type: news

Nigeria: Valentine's Day - NACA Cautions Young Nigerians Against Unprotected Sex
[This Day] As Nigerians join the rest of the world to mark Valentine's Day tomorrow, the National Agency for the Control of AIDS (NACA) has cautioned young people against risky sexual behaviours. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - February 13, 2020 Category: African Health Source Type: news

2011 to 2018 Saw Decline in Problems Paying Medical Bills
Percent of persons in families with problems paying bills higher for women, children, non - Hispanic blacks (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - February 13, 2020 Category: Cancer & Oncology Tags: Cardiology, Dermatology, Endocrinology, Family Medicine, Geriatrics, Gastroenterology, Gynecology, Infections, AIDS, Internal Medicine, Allergy, Critical Care, Emergency Medicine, Nephrology, Neurology, Nursing, Oncology, Ophthalmology, Orthopedics, ENT, Source Type: news

Structural basis of second-generation HIV integrase inhibitor action and viral resistance
Although second-generation HIV integrase strand-transfer inhibitors (INSTIs) are prescribed throughout the world, the mechanistic basis for the superiority of these drugs is poorly understood. We used single-particle cryo–electron microscopy to visualize the mode of action of the advanced INSTIs dolutegravir and bictegravir at near-atomic resolution. Glutamine-148->histidine (Q148H) and glycine-140->serine (G140S) amino acid substitutions in integrase that result in clinical INSTI failure perturb optimal magnesium ion coordination in the enzyme active site. The expanded chemical scaffolds of second-generation c...
Source: ScienceNOW - February 13, 2020 Category: Science Authors: Cook, N. J., Li, W., Berta, D., Badaoui, M., Ballandras-Colas, A., Nans, A., Kotecha, A., Rosta, E., Engelman, A. N., Cherepanov, P. Tags: Biochemistry, Microbiology reports Source Type: news

Youth With HIV Less Likely to Achieve Viral Suppression Youth With HIV Less Likely to Achieve Viral Suppression
About one in three U.S. youth diagnosed with HIV will start antiretroviral therapy (ART), while just fewer than one in eight achieve viral suppression, according to new findings.Reuters Health Information (Source: Medscape Hiv-Aids Headlines)
Source: Medscape Hiv-Aids Headlines - February 12, 2020 Category: Infectious Diseases Tags: HIV/AIDS News Source Type: news

Applying Guidelines for NAFLD in HIV-Monoinfected Patients Applying Guidelines for NAFLD in HIV-Monoinfected Patients
Current guidelines recommend the use of a diagnostic algorithm to screen for NAFLD. Could these guidelines also be applied to HIV-monoinfected patients?HIV Medicine (Source: Medscape Hiv-Aids Headlines)
Source: Medscape Hiv-Aids Headlines - February 12, 2020 Category: Infectious Diseases Tags: HIV/AIDS Journal Article Source Type: news

Age Makes the Difference in Sticking With HIV Meds
WEDNESDAY, Feb. 12, 2020 -- Young people with HIV have much lower rates of viral suppression than adults with the AIDS-causing virus, a new U.S. study finds. Viral suppression means that HIV has been reduced to undetectable levels. Maintaining viral... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - February 12, 2020 Category: General Medicine Source Type: news