Fight Aging! Newsletter, January 20th 2020
This study provides strong evidence that following a healthy lifestyle can substantially extend the years a person lives disease-free." Commentary on Recent Evidence for Cognitive Decline to Precede Amyloid Aggregation in Alzheimer's Disease https://www.fightaging.org/archives/2020/01/commentary-on-recent-evidence-for-cognitive-decline-to-precede-amyloid-aggregation-in-alzheimers-disease/ I can't say that I think the data presented in the research noted here merits quite the degree of the attention that it has been given in the popular science press. It is interesting, but not compelling if its role is to be evidence for a lack of correlation between amyloid-β and cognitive decline. When thinking about the early stages of loss of cognitive function, in which changes are small and subtle, one might have to consider other factors such as vascular dysfunction or other neurodegenerative conditions with quite different mechanisms that could produce these effects. The interplay and relative importance of the field of mechanisms at this stage of aging is far from clear. Nonetheless, the present mood of the scientific community and its onlookers is that of a growing revolt against the amyloid cascade hypothesis of Alzheimer's disease, so research that ties into that mood receives attention. There has been a longstanding belief among neuroscientists, backed by scientific evidence, that beta-amyloid, a protein that can clump together and form stick...
Publication date: Available online 16 September 2020Source: Respiratory Medicine Case ReportsAuthor(s): V. Thadchanamoorthy, Kavinda Dayasiri
CONCLUSIONS: Web-based methods need to be complemented by context-tailored, street-outreach activities to recruit rural PWUD. PMID: 32933438 [PubMed - as supplied by publisher]
CONCLUSIONS: Animal-encounter fatalities, analyzed by UCD alone, may be underreported. An initiating animal injury, complicated by comorbidities and fatality, may obscure the causal chain, resulting in misreporting UCD. Ongoing training for medical certifiers is recommended, highlighting accurate identification of UCD and contributing causes in the causal chain of death. PMID: 32933400 [PubMed - as supplied by publisher]
CONCLUSION: The positive association between PA and other healthy behaviors represents synergistic health activities, with healthy behaviors supporting others. PMID: 32937600 [PubMed - as supplied by publisher]
CONCLUSION: In patients with axSpA, a moderate/high AS-WIS score was predictive of AWO in this population with well-controlled axSpA. This short questionnaire can be helpful to screen for future difficulties at work. PMID: 32934129 [PubMed - as supplied by publisher]
CONCLUSION: This exercise confirmed good reliability of HR-pQCT erosion measurements and their ability to detect change over time. PMID: 32934121 [PubMed - as supplied by publisher]
Publication date: Available online 16 September 2020Source: European Journal of RadiologyAuthor(s): Masaya Kawaguchi, Hiroki Kato, Hiroyuki Tomita, Akira Hara, Natsuko Suzui, Tatsuhiko Miyazaki, Kanako Matsuyama, Mariko Seishima, Masayuki Matsuo
PET/MRI helps clinicians stage cancer treatment as well as PET/CT -- and finds...Read more on AuntMinnie.comRelated Reading: PET/MRI ups lesion detection by 15% for some cancers SNMMI 2020: PET/MRI finds location of chronic pain in patients SNMMI 2020: PET/MRI combo tracks osteoarthritis progression PET, MRI uncover women's predisposition to Alzheimer's PET/MRI shows inflammation link to mitral valve prolapse
Authors: Pintus R, Bongiovanni T, Corbu S, Francavilla VC, Dessí A, Noto A, Corsello G, Finco G, Fanos V, Marincola FC Abstract BACKGROUND: Sportomics is the application of metabolomics to study the metabolism shifts of individuals that practice sports or do physical exercise. This aim is reached by the analysis of low molecular weight metabolites (
New data reinforce strong clinical profile of Vitrakvi™ for patients of all ages with TRK Fusion Cancer including lung and thyroid tumors78% overall response rate (ORR) and median progression-free survival (PFS) of more than 3 years (36.8 months) demonstrate extended benefit in updated data set of 175 adults and children / Majority of adverse events were grade 1 or 2; no new safety signals identified / Consistently high ORRs shown in lung and thyroid data subsets (71 and 75%, respectively) as well as long durability (estimated duration of response at 12 months of 88% and 95%, respectively) / Among patients from integ...
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