ALS research reveals new treatment approach
(Sanford Burnham Prebys Medical Discovery Institute) New research on amyotrophic lateral sclerosis (AML) has revealed that a protein called membralin plays a key role in the disease process. The study, published in Journal of Clinical Investigation, suggests that membralin-boosting gene therapy is a potential therapeutic direction to treat this often deadly disease. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - May 23, 2019 Category: Biology Source Type: news

Experimental Agent Shows Promise in Slowing Genetic Form of ALS Experimental Agent Shows Promise in Slowing Genetic Form of ALS
Researchers successfully target elevated levels of a harmful protein, offering hope to people with a genetic form of amyotrophic lateral sclerosis.Medscape Medical News (Source: Medscape Neurology and Neurosurgery Headlines)
Source: Medscape Neurology and Neurosurgery Headlines - May 3, 2019 Category: Neurology Tags: Neurology & Neurosurgery News Source Type: news

Pluripotency or differentiation -- That is the question
(Helmholtz Zentrum M ü nchen - German Research Center for Environmental Health) Induced pluripotent stem cells can turn into any type of cell in the body or remain in their original form. In Molecular Cell, scientists from the Helmholtz Zentrum M ü nchen describe how cells 'decide' which of these two directions to take. During their research, they identified a protein and a ribonucleic acid (RNA) that play a highly significant role in this process. Their discovery also allows a better understanding of amyotrophic lateral sclerosis (ALS)*. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 2, 2019 Category: International Medicine & Public Health Source Type: news

Experimental treatment could be 'game-changing' for genetic ALS, experts say
An experimental treatment for the rapidly progressive disease ALS, or amyotrophic lateral sclerosis, has been called potentially "game-changing." (Source: CNN.com - Health)
Source: CNN.com - Health - May 1, 2019 Category: Consumer Health News Source Type: news

Scientists Create Speech From Brain Signals
A prosthetic voice decodes what the brain intends to say and generates (mostly) understandable speech, no muscle movement needed. (Source: NYT Health)
Source: NYT Health - April 24, 2019 Category: Consumer Health News Authors: BENEDICT CAREY Tags: Stroke Brain Epilepsy Amyotrophic Lateral Sclerosis Emory University Georgia Institute of Technology Mayo Clinic Nature (Journal) University of California, Berkeley University of California, San Francisco Bauby, Jean-Dominique your-f Source Type: news

Scientists create decoder to turn brain activity into speech
Technology could in effect give voice back to people with conditions such as Parkinson ’sScientists have developed a decoder that can translate brain activity directly into speech.In future the brain-machine interface could restore speech to people who have lost their voice through paralysis and conditions such as throat cancer, amyotrophic lateral sclerosis (ALS) and Parkinson ’s disease.Continue reading... (Source: Guardian Unlimited Science)
Source: Guardian Unlimited Science - April 24, 2019 Category: Science Authors: Hannah Devlin Science correspondent Tags: Medical research Neuroscience Cancer Parkinson's disease Health Society Source Type: news

African-Americans With ALS Survive Longer Than Caucasians
MONDAY, April 22, 2019 -- For people with amyotrophic lateral sclerosis (ALS), African-Americans have longer survival than Caucasians when death is the outcome, but not when the outcome is death or tracheostomy and invasive ventilation (TIV),... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - April 22, 2019 Category: Pharmaceuticals Source Type: news

Research reveals how the most common ALS mutation dooms cells
(St. Jude Children's Research Hospital) St. Jude Children's Research Hospital scientists have cracked the mystery surrounding the most common genetic cause of amyotrophic lateral sclerosis (ALS), or Lou Gehrig's disease. The research suggests possible new approaches to diagnosis and treatment of the lethal disorder. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 10, 2019 Category: International Medicine & Public Health Source Type: news

Biochemical switches identified that could be triggered to treat muscle, brain disorders
(St. Jude Children's Research Hospital) St. Jude Children's Research Hospital scientists have found that the enzymes ULK1 and ULK2 play a key role in breaking down cell structures called stress granules, whose persistence leads to toxic buildup of proteins that kill muscle and brain cells. Such buildup is central to the pathology of three related diseases: inclusion body myopathy (IBM), amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 10, 2019 Category: International Medicine & Public Health Source Type: news

Researchers reveal novel therapeutic strategy for ALS
(Chinese Academy of Sciences Headquarters) Researchers from the Institute of Neuroscience and their collaborators revealed a new cellular mechanism for amyotrophic lateral sclerosis (ALS), suggested a novel therapeutic strategy targeting the RNA degradation pathway, and identified an asthma drug as a potential medication for ALS. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - April 9, 2019 Category: International Medicine & Public Health Source Type: news

In the Loop: Sandra Murphy-Pak and the Xavier Project -- creating the future of living with ALS
Sandra Murphy-Pak is not taking?amyotrophic lateral sclerosis, or ALS, lying down. Far from it, in fact. As?we noted?this past January, she's not letting the disease stand in the way of?her life as an artist. She's also helping to create "better therapies, if not a cure,?for those diagnosed with ALS in the future" by continually donating [...] (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - April 9, 2019 Category: Databases & Libraries Source Type: news

Blacks Live Longer, Not Necessarily Better, With ALS
FRIDAY, April 5, 2019 -- Black Americans with amyotrophic lateral sclerosis (ALS) tend to live longer than whites with the disease because blacks are more likely to have a procedure called a tracheostomy, a new study shows. But that may not always... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - April 5, 2019 Category: General Medicine Source Type: news

Spatiotemporal dynamics of molecular pathology in amyotrophic lateral sclerosis
Paralysis occurring in amyotrophic lateral sclerosis (ALS) results from denervation of skeletal muscle as a consequence of motor neuron degeneration. Interactions between motor neurons and glia contribute to motor neuron loss, but the spatiotemporal ordering of molecular events that drive these processes in intact spinal tissue remains poorly understood. Here, we use spatial transcriptomics to obtain gene expression measurements of mouse spinal cords over the course of disease, as well as of postmortem tissue from ALS patients, to characterize the underlying molecular mechanisms in ALS. We identify pathway dynamics, distin...
Source: ScienceNOW - April 4, 2019 Category: Science Authors: Maniatis, S., Äijö, T., Vickovic, S., Braine, C., Kang, K., Mollbrink, A., Fagegaltier, D., Andrusivova, Z., Saarenpää, S., Saiz-Castro, G., Cuevas, M., Watters, A., Lundeberg, J., Bonneau, R., Phatnani, H. Tags: Molecular Biology, Neuroscience reports Source Type: news

Lauren Sciences LLC wins AU$1 million grant award from FightMND
(Lauren Sciences LLC) Lauren Sciences LLC, the private New York biotechnology company developing transformative V-Smart ® Nanomedicines for brain diseases, today announced it was awarded an AU$1 million translational grant from FightMND. The FightMND grant will advance Lauren Sciences development of LAUR-301, its novel V-Smart ® Nanomedicine for ALS (amyotrophic lateral sclerosis), also known as Lou Gehrig's disease, or motor neuron disease (MND). (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 2, 2019 Category: International Medicine & Public Health Source Type: news

Transplanted bone marrow endothelial progenitor cells delay ALS disease progression
(University of South Florida (USF Innovation)) Transplanting human bone marrow-derived endothelial progenitor cells into mice mimicking symptoms of amyotrophic lateral sclerosis (ALS) helped more motor neurons survive and slowed disease progression by repairing damage to the blood-spinal cord barrier, University of South Florida researchers report. The new research, published recently in Scientific Reports, contributes to a growing body of work exploring cell therapy approaches to barrier repair in ALS and other neurodegenerative diseases. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - April 2, 2019 Category: Biology Source Type: news

Nursing professor wins $6.575 million in grants to tackle musculoskeletal disease
(University of Texas at Arlington) Marco Brotto -- the George W. and Hazel M. Jay Professor in the college, and an internationally renowned scientist and an expert in bone, muscle physiology and sarcopenia -- recently obtained renewal for two grants, and funding for three new grants from the National Institutes of Health. These awards will further his work in tackling sarcopenia and osteoporosis, and support his new work on diabetic skeletal muscle disease and amyotrophic lateral sclerosis, also known as ALS or Lou Gehrig's disease. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - March 15, 2019 Category: Biology Source Type: news

Playing Professional Soccer Linked to Increased ALS Risk Playing Professional Soccer Linked to Increased ALS Risk
Italian professional soccer players have a twofold increased risk for amyotrophic lateral sclerosis (ALS), and those who develop the disease do so at a relatively young age.Medscape Medical News (Source: Medscape Neurology and Neurosurgery Headlines)
Source: Medscape Neurology and Neurosurgery Headlines - March 4, 2019 Category: Neurology Tags: Neurology & Neurosurgery News Source Type: news

Are Soccer Pros at Higher Risk for ALS?
THURSDAY, Feb. 28, 2019 -- Professional soccer players may be vulnerable to amyotrophic lateral sclerosis (ALS), a new study suggests. The Italian researchers also found that soccer players may develop the neurodegenerative disease at a much younger... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - February 28, 2019 Category: General Medicine Source Type: news

Footballers are FIVE times more likely to get the condition that killed Professor Stephen Hawking
Hawking died in 2018 of amyotrophic lateral sclerosis, a neurological disease. Italian researchers found that footballers could develop ALS 21 years earlier than average. (Source: the Mail online | Health)
Source: the Mail online | Health - February 28, 2019 Category: Consumer Health News Source Type: news

AAN: Professional Soccer Players Show Increased Risk for ALS
THURSDAY, Feb. 28, 2019 -- Professional soccer players may have an increased risk for amyotrophic lateral sclerosis (ALS), according to a study scheduled for presentation at the upcoming annual meeting of the American Academy of Neurology, to be... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - February 28, 2019 Category: Pharmaceuticals Source Type: news

Could medical marijuana help grandma and grandpa with their ailments?
Medical marijuana may bring relief to older people who have symptoms like pain, sleep disorders or anxiety due to chronic conditions including amyotrophic lateral sclerosis, Parkinson's disease, neuropathy, spinal cord damage and multiple sclerosis, according to a preliminary study released today that will be presented at the American Academy of Neurology's 71st Annual Meeting in Philadelphia, May 4 to 10, 2019. (Source: World Pharma News)
Source: World Pharma News - February 28, 2019 Category: Pharmaceuticals Tags: Featured Research Research and Development Source Type: news

Could medical marijuana help grandma and grandpa with their ailments?
(American Academy of Neurology) Medical marijuana may bring relief to older people who have symptoms like pain, sleep disorders or anxiety due to chronic conditions including amyotrophic lateral sclerosis, Parkinson's disease, neuropathy, spinal cord damage and multiple sclerosis, according to a preliminary study released today that will be presented at the American Academy of Neurology's 71st Annual Meeting in Philadelphia, May 4-10, 2019. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - February 28, 2019 Category: International Medicine & Public Health Source Type: news

Contact sports as a risk factor for amyotrophic lateral sclerosis: a systematic review - Blecher R, Elliott MA, Yilmaz E, Dettori JR, Oskouian RJ, Patel A, Clarke A, Hutton M, McGuire R, Dunn R, DeVine J, Twaddle B, Chapman JR.
STUDY DESIGN: Systematic review. INTRODUCTION: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease, ultimately resulting in paralysis and death. The condition is considered to be caused by a complex interaction between en... (Source: SafetyLit)
Source: SafetyLit - February 23, 2019 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news

FDA goes after California stem cell doc for unapproved breast implant device
The FDA this week sent a warning letter to a Beverly Hills, Calif.-based surgeon for their marketing of an unapproved implantable device, dubbed the Pocket Protector, which the surgeon claims can prevent and treat capsular contracture, or scar tissue tightening, during breast implant procedures. In its letter, the federal watchdog also accuses the surgeon, Dr. Mark Berman, of “significant deviations from the FDA’s quality system requirements and current good manufacturing practices,” including charges related to the sterility of implantable devices. “This is not the first time the FDA has notified D...
Source: Mass Device - February 15, 2019 Category: Medical Devices Authors: Fink Densford Tags: Cosmetic/Aesthetic Featured Food & Drug Administration (FDA) Stem Cells Source Type: news

Heterochromatin anomalies and double-stranded RNA accumulation underlie C9orf72 poly(PR) toxicity
How hexanucleotide GGGGCC (G4C2) repeat expansions in C9orf72 cause frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) is not understood. We developed a mouse model engineered to express poly(PR), a proline-arginine (PR) dipeptide repeat protein synthesized from expanded G4C2 repeats. The expression of green fluorescent protein–conjugated (PR)50 (a 50-repeat PR protein) throughout the mouse brain yielded progressive brain atrophy, neuron loss, loss of poly(PR)-positive cells, and gliosis, culminating in motor and memory impairments. We found that poly(PR) bound DNA, localized to heterochromatin, an...
Source: ScienceNOW - February 14, 2019 Category: Science Authors: Zhang, Y.-J., Guo, L., Gonzales, P. K., Gendron, T. F., Wu, Y., Jansen-West, K., ORaw, A. D., Pickles, S. R., Prudencio, M., Carlomagno, Y., Gachechiladze, M. A., Ludwig, C., Tian, R., Chew, J., DeTure, M., Lin, W.-L., Tong, J., Daughrity, L. M., Yue, M., Tags: Medicine, Diseases, Online Only r-articles Source Type: news

Correlation of falls in patients with amyotrophic lateral sclerosis with objective measures of balance, strength, and spasticity - Schell WE, Mar VS, Da Silva CP.
BACKGROUND: Persons diagnosed with Amyotrophic Lateral Sclerosis (ALS) often demonstrate neurological deficits that predispose them to repeated falls and associated adverse consequences. Determining contributing factors to falls in this population is criti... (Source: SafetyLit)
Source: SafetyLit - February 6, 2019 Category: International Medicine & Public Health Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news

New therapy for amyotrophic lateral sclerosis successfully tested on mice
(Universit é Laval) A team from Universit é Laval and the CERVO Brain Research Centre has demonstrated the efficacy in mice of a new therapy that addresses the main manifestation of amyotrophic lateral sclerosis (ALS). The researchers developed an antibody that reduces the number of TDP-43 protein aggregates in the brains of mice with ALS, resulting in significant improvements in their cognitive and motor performance. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 6, 2019 Category: International Medicine & Public Health Source Type: news

Medical News Today: ALS: A new therapy may be in sight
New research, led by Harvard scientists, identifies a novel potential therapeutic target for treating amyotrophic lateral sclerosis (ALS). (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - January 17, 2019 Category: Consumer Health News Tags: Muscular Dystrophy / ALS Source Type: news

#MayoClinicRadio podcast: 1/12/19
Listen: Mayo Clinic Radio 1/12/19 On the Mayo Clinic Radio podcast,?Dr. Jennifer Martinez-Thompson, a Mayo Clinic neurologist, discusses diagnosis and treatment options for amyotrophic lateral sclerosis (ALS). Also on the podcast, Dr. Molly Jeffery?and Dr. W. Michael Hooten?share new Mayo Clinic research on trends in opioid use.?Dr. Jeffery is the scientific director of Emergency Medicine [...] (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - January 14, 2019 Category: Databases & Libraries Source Type: news

National Geographic Takes an Interest in Organs-on-Chips Research
Biomedical researchers at Cedars-Sinai Medical Center in Los Angeles, CA have caught the attention of National Geographic. The magazine published a special edition this month covering "The Future of Medicine" that highlights the innovative stem-cell science of Cedars-Sinai, showing how investigators there are seeking to use stem cells and organs-on-chips to tailor personalized medical treatments. The cover photo of the special issue features research being conducted at Cedars-Sinai in collaboration with Boston, MA-based Emulate, a startup developing a tissue-based technology designed to replicate human organ-leve...
Source: MDDI - January 11, 2019 Category: Medical Devices Authors: Amanda Pedersen Tags: R & D Source Type: news

New Technique Could Be a Breakthrough for Motility Research
In this study, we showed a mitigation of these common problems with optogenetic muscle control,” said Hugh Herr, who led the research team and heads the Media Lab’s Biomechatronics group. “This has great promise for the development of solutions for patients suffering from debilitating conditions like muscle paralysis.” The group's research paper was published in the Dec. 13 issue of Nature Communications. Doctors already use electrical nerve stimulation to treat patients with spinal cord injury, and to improve muscle conditionin...
Source: MDDI - January 2, 2019 Category: Medical Devices Authors: Amanda Pedersen Tags: R & D Source Type: news

10 Top Questions You Had For Dr. Google In 2018
(CNN) — People were curious about the keto diet, ALS and endometriosis in 2018. Those are just a few of the health-related topics that had Internet surfers in the United States turning to Dr. Google with questions this year, according to a top 10 list from the search engine giant. The data, based on search terms, was collected from January to mid-December. Last year, some of the top health-related questions searched on Google included what causes hiccups, how to stop snoring, how long flu lasts and what is lupus. Some of the top health-related questions on Google in 2016 were related to Zika, traumatic brain injuries...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - December 21, 2018 Category: Consumer Health News Authors: Health – CBS Boston Tags: Health News Offbeat Google Local TV Source Type: news

Prevalence of Amyotrophic Lateral Sclerosis -- US, 2015 Prevalence of Amyotrophic Lateral Sclerosis -- US, 2015
The prevalence data presented in this report aims to further our understanding of the epidemiology of ALS cases in the United States.Morbidity & Mortality Weekly Report (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - December 17, 2018 Category: Consumer Health News Tags: Neurology & Neurosurgery Journal Article Source Type: news

Regulated proteolysis of p62/SQSTM1 enables differential control of autophagy and nutrient sensing
The multidomain scaffold protein p62 (also called sequestosome-1) is involved in autophagy, antimicrobial immunity, and oncogenesis. Mutations in SQSTM1, which encodes p62, are linked to hereditary inflammatory conditions such as Paget’s disease of the bone, frontotemporal dementia (FTD), amyotrophic lateral sclerosis, and distal myopathy with rimmed vacuoles. Here, we report that p62 was proteolytically trimmed by the protease caspase-8 into a stable protein, which we called p62TRM. We found that p62TRM, but not full-length p62, was involved in nutrient sensing and homeostasis through the mechanistic target of rapam...
Source: Signal Transduction Knowledge Environment - December 4, 2018 Category: Science Authors: Sanchez-Garrido, J., Sancho-Shimizu, V., Shenoy, A. R. Tags: STKE Research Articles Source Type: news

Biohaven Announces FDA Acceptance of 505(b)(2) NDA Filing for BHV-0223, a Novel Sublingual Delivery Form of Riluzole for the Treatment of Amyotrophic Lateral Sclerosis (ALS)
If approved, BHV-0223 would become the only formulation of riluzole that does not require swallowing tablets or liquids, offering an important delivery alternative for the standard-of-care treatment of ALS Riluzole is the only FDA-approved treatment for... Biopharmaceuticals, Neurology, Drug Delivery, FDA Biohaven Pharmaceutical, riluzole, amyotrophic lateral sclerosis (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - November 26, 2018 Category: Pharmaceuticals Source Type: news

CDC: U.S. Prevalence of ALS Was 5.2 Per 100,000 in 2015
MONDAY, Nov. 26, 2018 -- In 2015, the prevalence of amyotrophic lateral sclerosis (ALS) in the United States was 5.2 per 100,000 population, with 16,583 cases identified, according to research published in the Nov. 23 issue of the U.S. Centers for... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - November 26, 2018 Category: Pharmaceuticals Source Type: news

Wish to die and reasons for living among patients with amyotrophic lateral sclerosis - Verschueren A, Kianimehr G, Belingher C, Salort-Campana E, Loundou A, Grapperon AM, Attarian S.
OBJECTIVE: In Amyotrophic lateral sclerosis (ALS), disease severity, ineffective treatment, and increasing dependence on caregivers may give rise to hopelessness and suicidal ideation among patients. In clinical practice, the desire for death among patient... (Source: SafetyLit)
Source: SafetyLit - November 17, 2018 Category: International Medicine & Public Health Tags: Suicide and Self-Harm Source Type: news

New way to study swallowing could one day lead to improved treatments for ALS
(University of Missouri-Columbia) There is no cure for amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's Disease, but new findings from the University of Missouri School of Medicine and the University of Missouri College of Veterinary Medicine are deepening researchers' understanding of a common ALS symptom: swallowing problems. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 14, 2018 Category: International Medicine & Public Health Source Type: news

Trying to understand cells' interior design
(Institute for Basic Science) IBS Scientists have explained how liquid-like droplets made of proteins and DNA form in vitro. Currently, there is a huge interest in understanding the molecular mechanisms behind the creation of such droplets, as it is linked to some human diseases, such as amyotrophic lateral sclerosis (ALS). The results showed how much the sequence of DNA matters in the formation of such droplets. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - November 6, 2018 Category: Biology Source Type: news

Researchers identify promising proteins for diagnostic, prognostic use in ALS
(North Carolina State University) Researchers from North Carolina State University have identified proteins that may be useful in both earlier diagnosis of Amyotrophic Lateral Sclerosis (ALS) and in more accurate disease prognosis. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 5, 2018 Category: International Medicine & Public Health Source Type: news

Normal function of ALS and dementia linked gene determined for the first time
(University of Bath) The normal function of a gene associated with the neurodegenerative diseases amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) has been determined for the first time by University of Bath scientists. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - October 24, 2018 Category: International Medicine & Public Health Source Type: news

CavoGene LifeSciences Licenses Novel Gene Therapy for CNS Disorders
Agreement with University California San Diego Provides License for Production of SynCav1, an Investigational Novel Gene Therapy for Treatment of Alzheimer's Disease and Amyotrophic Lateral Sclerosis GLEN BURNIE, Md., Oct. 23, 2018 -- (Healthcare Sales ... Biopharmaceuticals, Neurology, Licensing CavoGene LifeSciences, SynCav1, Alzheimer's disease, neurodegenerative disease (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - October 23, 2018 Category: Pharmaceuticals Source Type: news

Organs-on-chip technology reveals new drug candidates for Lou Gehrig's disease
The investigation of amyotrophic lateral sclerosis (ALS) - also known as Lou Gehrig's disease - through muscle-on-a-chip technology has revealed a new drug combination that may serve as an effective treatment of the progressive neurodegenerative disease. These findings highlight organ-on-a-chip technologies - in which live conditions of the body are mimicked in a microfluidic cell culture - as promising platforms for (Source: World Pharma News)
Source: World Pharma News - October 10, 2018 Category: Pharmaceuticals Tags: Featured Research Research and Development Source Type: news

Psychiatric disorders in C9orf72 kindreds: study of 1,414 family members - Devenney EM, Ahmed RM, Halliday G, Piguet O, Kiernan MC, Hodges JR.
OBJECTIVE: The aim of this study was to determine in a systematic manner if the C9orf72 phenotype might extend beyond frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) to include psychiatric disease. METHODS: A validated ... (Source: SafetyLit)
Source: SafetyLit - October 5, 2018 Category: International Medicine & Public Health Tags: Suicide and Self-Harm Source Type: news

Cognitive and Behavior Changes Common Early in ALS Cognitive and Behavior Changes Common Early in ALS
New evidence shows that unlike previously thought, behavior and cognitive domains are significantly affected early in the course of amyotrophic lateral sclerosis.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - September 14, 2018 Category: Consumer Health News Tags: Neurology & Neurosurgery News Source Type: news

ALS Affects the Mind, Not Just the Body
THURSDAY, Sept. 13, 2018 -- The minds of patients suffering from amyotrophic lateral sclerosis (ALS) are damaged by the disease, despite the longstanding belief that this was not the case, a new study reveals. In fact, in the later stages of ALS,... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - September 13, 2018 Category: General Medicine Source Type: news

Finding that links ALS/ataxia to cellular stress opens new approaches for treatment
(University of Utah) Scientists at University of Utah Health report for the first time that a protein, called Staufen1, accumulates in cells of patients suffering from degenerative ataxia or amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease. Depleting the protein from affected mice improved symptoms including motor function. These results suggest that targeting Staufen1 could have therapeutic potential in people. The research is published in Nature Communications. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - September 7, 2018 Category: International Medicine & Public Health Source Type: news

ITF Pharma Announces FDA Approval of Tiglutik (riluzole) Oral Suspension for the Treatment of Amyotrophic Lateral Sclerosis (ALS)
BERWYN, Pa., Sept. 6, 2018 /PRNewswire/ -- ITF Pharma, a U.S.-based specialty pharmaceutical company and a subsidiary of Italfarmaco, a privately-held European specialty pharmaceutical company, committed to investing in and commercializing impactful... (Source: Drugs.com - New Drug Approvals)
Source: Drugs.com - New Drug Approvals - September 6, 2018 Category: Drugs & Pharmacology Source Type: news

Berwyn pharma firm gets approval for ALS drug
The Food and Drug Administration has approved ITF Pharma ’s new drug application for Tiglutik, a treatment for amyotrophic lateral sclerosis or ALS. Tiglutik is, according to ITF Pharma, the first and only easy-to-swallow thickened riluzole liquid for ALS. The medicine is administered twice daily by oral syringe. ALS, also known as Lou Gehrig’s dise ase, is a progressive and ultimately fatal neurodegenerative disease marked by a gradual degeneration of nerve cells of the central nervous system… (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - September 6, 2018 Category: Biotechnology Authors: John George Source Type: news

Patient Distressed by Overturn of California End of Life Option Act
TUESDAY, Sept. 4, 2018 -- The decision to overturn the End of Life Option Act has added stress and anxiety to terminally ill patients, including those with amyotrophic lateral sclerosis (ALS), according to a patient testimonial published online... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - September 4, 2018 Category: Pharmaceuticals Source Type: news